Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLEC	5339	broad.mit.edu	37	8	144996316	144996316	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144996316C>T	ENST00000322810.4	-	32	8253	c.8084G>A	c.(8083-8085)cGg>cAg	p.R2695Q	PLEC_ENST00000527096.1_Missense_Mutation_p.R2581Q|PLEC_ENST00000356346.3_Missense_Mutation_p.R2544Q|PLEC_ENST00000436759.2_Missense_Mutation_p.R2585Q|PLEC_ENST00000357649.2_Missense_Mutation_p.R2562Q|PLEC_ENST00000354589.3_Missense_Mutation_p.R2558Q|PLEC_ENST00000398774.2_Missense_Mutation_p.R2526Q|PLEC_ENST00000345136.3_Missense_Mutation_p.R2558Q|PLEC_ENST00000354958.2_Missense_Mutation_p.R2536Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2695	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CTCATGCTGCCGCCGCCGCGC	0.706000													3	12					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156235591	156235591	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156235591T>C	ENST00000361813.5	-	12	1980	c.1836A>G	c.(1834-1836)gtA>gtG	p.V612V	SMG5_ENST00000368267.4_Intron	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	612					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					AAGGCTTGTCTACATCCCCAT	0.577000													64	199					0	0	1	0	0
CHCHD2	51142	broad.mit.edu	37	7	56171984	56171984	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:56171984C>T	ENST00000395422.3	-	2	397	c.235G>A	c.(235-237)Gcc>Acc	p.A79T		NM_016139.2	NP_057223.1	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 2	79						mitochondrion				endometrium(1)|large_intestine(1)|lung(3)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCAGTAATGGCGTGACCCAAT	0.602000													31	83					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18319255	18319255	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18319255T>C	ENST00000396253.3	-	10	1294	c.832A>G	c.(832-834)Act>Gct	p.T278A	HPS5_ENST00000438420.2_Missense_Mutation_p.T278A|HPS5_ENST00000531848.1_Missense_Mutation_p.T278A|HPS5_ENST00000349215.3_Missense_Mutation_p.T392A	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	392						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						GCAGTCAAAGTTTTTCTTGCC	0.368000									Hermansky-Pudlak syndrome				6	99					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56722344	56722344	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56722344T>C	ENST00000425394.2	-	3	740	c.364A>G	c.(364-366)Atc>Gtc	p.I122V	PAN2_ENST00000257931.5_Missense_Mutation_p.I122V|PAN2_ENST00000548043.1_Missense_Mutation_p.I122V|PAN2_ENST00000440411.3_Missense_Mutation_p.I122V	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	122					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGGCTCTGGATCTGCCGAATA	0.468000													45	94					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134002615	134002615	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:134002615C>T	ENST00000398844.2	+	3	956	c.668C>T	c.(667-669)gCc>gTc	p.A223V	SEC24A_ENST00000322887.4_Missense_Mutation_p.A223V	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	223	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCAGTGAGGGCCCTCACGCCC	0.517000													17	104					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61770959	61770959	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:61770959C>T	ENST00000361357.3	+	17	2114	c.1796C>T	c.(1795-1797)gCa>gTa	p.A599V	MAP3K3_ENST00000579585.1_Missense_Mutation_p.A599V|MAP3K3_ENST00000577395.1_Missense_Mutation_p.A564V|MAP3K3_ENST00000361733.3_Missense_Mutation_p.A568V|MAP3K3_ENST00000584573.1_Missense_Mutation_p.A595V	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	568	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						CCACCGTGGGCAGAGTATGAA	0.602000													35	107					0	0	1	0	0
C3orf17	25871	broad.mit.edu	37	3	112730221	112730221	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:112730221A>G	ENST00000314400.5	-	6	775	c.584T>C	c.(583-585)aTt>aCt	p.I195T	C3orf17_ENST00000393857.2_Missense_Mutation_p.I59T|C3orf17_ENST00000383675.2_Missense_Mutation_p.I125T	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	195						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						ATATAACAAAATCAACCTTTT	0.343000													41	100					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35205733	35205733	+	Missense_Mutation	SNP	C	C	T	rs17854740		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:35205733C>T	ENST00000274938.7	+	7	767	c.767C>T	c.(766-768)aCt>aTt	p.T256I	SCUBE3_ENST00000394681.1_Missense_Mutation_p.T272I	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	256	EGF-like 6.			T -> I (in Ref. 6; AAH52263).	protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						GATGCAGCGACTGGTGTCCAC	0.547000													41	114					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139756833	139756833	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:139756833A>G	ENST00000263549.3	-	3	1456	c.583T>C	c.(583-585)Tgt>Cgt	p.C195R		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	195						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					GATCTCTTACAGCTAGTGCCA	0.458000													42	111					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638471	234638471	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:234638471C>T	ENST00000482026.1	+	1	718	c.699C>T	c.(697-699)agC>agT	p.S233S	UGT1A5_ENST00000373414.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000480628.1_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTTATGCAAGCCTTGCCTCTG	0.493000													29	323					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36986173	36986173	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:36986173A>T	ENST00000282516.8	+	10	3390	c.2891A>T	c.(2890-2892)gAt>gTt	p.D964V	NIPBL_ENST00000504430.1_3'UTR|NIPBL_ENST00000448238.2_Missense_Mutation_p.D964V	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	964					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ATCAAGAGGGATAAAGATGGC	0.368000													34	129					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5047569	5047569	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:5047569T>C	ENST00000159111.4	+	6	733	c.515T>C	c.(514-516)gTg>gCg	p.V172A	KDM4B_ENST00000592175.1_3'UTR|KDM4B_ENST00000536461.1_Missense_Mutation_p.V172A|KDM4B_ENST00000381759.4_Missense_Mutation_p.V172A	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	172	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						ATCGAGGGCGTGAACACGCCC	0.622000													46	117					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108225545	108225545	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:108225545G>A	ENST00000278616.4	+	61	9179	c.8794G>A	c.(8794-8796)Gag>Aag	p.E2932K	C11orf65_ENST00000526725.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.E2932K|C11orf65_ENST00000525729.1_Intron|ATM_ENST00000525178.1_3'UTR	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2932	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TAGATGCTGTGAGAAAACCAT	0.343000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			46	125					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379796	88379796	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:88379796A>G	ENST00000298699.2	-	11	1137	c.957T>C	c.(955-957)agT>agC	p.S319S	C12orf50_ENST00000550553.1_Silent_p.S280S	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	319										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TGCGGTGATAACTCATTTTAT	0.438000													35	131					0	0	1	0	0
KAZALD1	81621	broad.mit.edu	37	10	102824394	102824394	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:102824394T>C	ENST00000370200.5	+	4	1135	c.809T>C	c.(808-810)gTg>gCg	p.V270A		NM_030929.4	NP_112191.2	Q96I82	KAZD1_HUMAN	Kazal-type serine peptidase inhibitor domain 1	270					cell differentiation|multicellular organismal development|ossification|regulation of cell growth		insulin-like growth factor binding			endometrium(1)|ovary(1)|prostate(2)	4				Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		AGCTTGACAGTGCTCACACCT	0.567000													20	59					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32698424	32698424	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:32698424G>A	ENST00000380250.3	+	5	962	c.464_splice	c.e5-1	p.D156_splice		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATTTTACAGCGATGAACAACA	0.313000													5	38					0	0	1	0	0
GNB1	2782	broad.mit.edu	37	1	1721839	1721839	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1721839T>C	ENST00000378609.4	-	9	1025	c.694A>G	c.(694-696)Att>Gtt	p.I232V		NM_002074.3	NP_002065.1	P62873	GBB1_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1	232					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	12	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		CTCACGCAAATGGCATTGATG	0.522000													4	76					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195785204	195785204	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:195785204G>T	ENST00000360110.4	-	16	1797	c.1628C>A	c.(1627-1629)cCt>cAt	p.P543H	TFRC_ENST00000420415.1_Missense_Mutation_p.P462H|TFRC_ENST00000392396.3_Missense_Mutation_p.P543H|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_Missense_Mutation_p.P261H|TFRC_ENST00000465288.1_5'UTR	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	543					cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		TGCAAGGAAAGGGAAAGCAGC	0.388000			T	BCL6	NHL								46	142					1.15181e-12	1.20023e-12	1	1	0
KIT	3815	broad.mit.edu	37	4	55561942	55561942	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:55561942T>C	ENST00000288135.5	+	2	429	c.332T>C	c.(331-333)gTt>gCt	p.V111A		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	111	Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TATGTGTTTGTTAGAGGTAAA	0.408000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				14	36					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206592754	206592754	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:206592754A>G	ENST00000360409.3	+	7	1921	c.1130A>G	c.(1129-1131)cAt>cGt	p.H377R	NRP2_ENST00000357785.5_Missense_Mutation_p.H377R|NRP2_ENST00000417189.1_Missense_Mutation_p.H377R|NRP2_ENST00000357118.4_Missense_Mutation_p.H377R|NRP2_ENST00000540178.1_Missense_Mutation_p.H377R|NRP2_ENST00000355117.4_Missense_Mutation_p.H377R|NRP2_ENST00000540841.1_Missense_Mutation_p.H377R|NRP2_ENST00000412873.2_Missense_Mutation_p.H377R|NRP2_ENST00000272849.3_Missense_Mutation_p.H377R	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	377	F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GTGTACCGGCATGGCAAAAAC	0.502000													21	52					0	0	1	0	0
MEGF9	1955	broad.mit.edu	37	9	123367647	123367647	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:123367647G>A	ENST00000373930.3	-	6	1741	c.1630C>T	c.(1630-1632)Cgg>Tgg	p.R544W	MEGF9_ENST00000426959.1_Missense_Mutation_p.R581W	NM_001080497.2	NP_001073966.2	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	544						integral to membrane	calcium ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	16						TTGAGTTTCCGGTTTTGGTAC	0.443000													38	135					0	0	1	0	0
CD320	51293	broad.mit.edu	37	19	8369979	8369979	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:8369979C>T	ENST00000301458.5	-	2	268	c.204G>A	c.(202-204)gtG>gtA	p.V68V	CD320_ENST00000537716.2_Intron	NM_016579.3	NP_057663.1	Q9NPF0	CD320_HUMAN	CD320 molecule	68	LDL-receptor class A 1.				regulation of cell growth	endoplasmic reticulum|integral to membrane	growth factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)	6						AGGTGAGGGGCACGCATAAGC	0.652000													9	25					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23293794	23293794	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:23293794G>A	ENST00000258733.4	+	3	525	c.230G>A	c.(229-231)cGt>cAt	p.R77H	GPNMB_ENST00000453162.2_Missense_Mutation_p.R77H|GPNMB_ENST00000381990.2_Missense_Mutation_p.R77H|GPNMB_ENST00000409458.3_Missense_Mutation_p.R77H|GPNMB_ENST00000539136.1_Intron			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	77					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			CTAGGAGGCCGTGTGCAGGCG	0.463000													48	140					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109675039	109675039	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:109675039C>T	ENST00000338432.7	+	34	4635	c.4516C>T	c.(4516-4518)Cgt>Tgt	p.R1506C	ACACB_ENST00000543201.1_Missense_Mutation_p.R172C|ACACB_ENST00000377848.3_Missense_Mutation_p.R1506C|ACACB_ENST00000377854.5_Missense_Mutation_p.R1436C			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1506					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TAACCGGATGCGTAACTTCGA	0.547000													64	110					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166205	140166205	+	Silent	SNP	C	C	T	rs138474048		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140166205C>T	ENST00000504120.2	+	1	330	c.330C>T	c.(328-330)gcC>gcT	p.A110A	PCDHA1_ENST00000378133.3_Silent_p.A110A|PCDHA1_ENST00000394633.3_Silent_p.A110A	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGATCGCCGACAGGCCGC	0.498000													44	147					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849370	98849370	+	RNA	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:98849370G>T	ENST00000554295.1	-	0	1553					NR_033801.1																						TGAAGAACACGATGAAAGGCG	0.522000													3	26					0.115264	0.1157	1	1	0
EPS15	2060	broad.mit.edu	37	1	51938592	51938592	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:51938592A>G	ENST00000371733.3	-	3	200	c.104T>C	c.(103-105)tTg>tCg	p.L35S	EPS15_ENST00000371730.2_Missense_Mutation_p.L35S	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	35	EH 1.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						ATCAGAAGCCAACACCCTTCC	0.373000			T	MLL	ALL								49	125					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19571743	19571743	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:19571743T>C	ENST00000507958.1	-	10	2188	c.1198A>G	c.(1198-1200)Acc>Gcc	p.T400A	CDH18_ENST00000506372.1_Missense_Mutation_p.T400A|CDH18_ENST00000511273.1_Missense_Mutation_p.T400A|CDH18_ENST00000502796.1_Missense_Mutation_p.T400A|CDH18_ENST00000274170.4_Missense_Mutation_p.T400A|CDH18_ENST00000382275.1_Missense_Mutation_p.T400A			Q13634	CAD18_HUMAN	cadherin 18, type 2	400	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCAACGACGGTCCCAATCTTG	0.418000													18	85					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28155586	28155586	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:28155586C>T	ENST00000316334.3	-	2	384	c.255G>A	c.(253-255)ccG>ccA	p.P85P		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	85							zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		TCCGGTCCAACGGACAGAAAT	0.388000													14	44					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58055944	58055944	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:58055944T>C	ENST00000556826.1	-	3	813	c.577A>G	c.(577-579)Aaa>Gaa	p.K193E	SLC35F4_ENST00000339762.6_Missense_Mutation_p.K229E|SLC35F4_ENST00000554729.1_Missense_Mutation_p.K70E	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CTGAATTTTTTCATTGGAGAT	0.328000													16	83					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161134060	161134060	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:161134060C>T	ENST00000308192.9	+	5	513	c.450C>T	c.(448-450)aaC>aaT	p.N150N	PLG_ENST00000462918.1_3'UTR	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	150	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGGAGGAGAACTACTGCAGGA	0.473000													34	146					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127236487	127236487	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:127236487A>G	ENST00000265825.5	+	3	1166	c.947A>G	c.(946-948)tAc>tGc	p.Y316C	FSCN3_ENST00000420086.2_Missense_Mutation_p.Y182C	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	316						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						GCCAATGGCTACTACCTATCC	0.507000													4	201					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41745209	41745209	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41745209C>A	ENST00000301178.4	+	9	1465	c.1275C>A	c.(1273-1275)gcC>gcA	p.A425A	AXL_ENST00000359092.3_Silent_p.A425A|AXL_ENST00000593513.1_Silent_p.A157A	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	425	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CCCTGGAGGCCTGGCGCCCAG	0.597000													24	94					1.55469e-16	1.63288e-16	1	1	0
MPHOSPH9	10198	broad.mit.edu	37	12	123705975	123705975	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123705975T>C	ENST00000606320.1	-	5	1022	c.816A>G	c.(814-816)gaA>gaG	p.E272E	MPHOSPH9_ENST00000392425.3_Silent_p.E120E|MPHOSPH9_ENST00000541076.2_Silent_p.E242E|MPHOSPH9_ENST00000302349.5_Silent_p.E120E			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	120					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GAAAATTATGTTCAAATTCAC	0.313000													9	81					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26965397	26965397	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:26965397C>A	ENST00000528896.2	-	13	1459	c.1385G>T	c.(1384-1386)cGg>cTg	p.R462L	KIAA0100_ENST00000389003.3_Missense_Mutation_p.R319L|KIAA0100_ENST00000544884.1_Missense_Mutation_p.R319L	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	462						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					TAGGACGCCCCGCTGATGGAT	0.577000													5	72					0.0293803	0.0295309	1	1	0
ZNF716	441234	broad.mit.edu	37	7	57528841	57528841	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:57528841C>T	ENST00000420713.1	+	4	786	c.674C>T	c.(673-675)tCt>tTt	p.S225F		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TTTAACTGCTCTTCAACCCTT	0.378000													4	27					0	0	1	0	0
TAS2R42	353164	broad.mit.edu	37	12	11338810	11338810	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:11338810A>G	ENST00000334266.1	-	1	733	c.734T>C	c.(733-735)gTt>gCt	p.V245A		NM_181429.1	NP_852094.1	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	245					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(2)|lung(4)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			AAAAAAATGAACTATGAAGAG	0.408000													4	144					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141335448	141335448	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:141335448A>T	ENST00000231484.3	-	1	3179	c.1969T>A	c.(1969-1971)Ttc>Atc	p.F657I		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	657	Cadherin 6.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATTGACGAACAGCTGCCCC	0.572000													12	45					0	0	1	0	0
RGL2	5863	broad.mit.edu	37	6	33264477	33264477	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:33264477T>A	ENST00000497454.1	-	4	812	c.317A>T	c.(316-318)gAt>gTt	p.D106V	RGL2_ENST00000444031.2_Missense_Mutation_p.D24V|PFDN6_ENST00000463584.1_Intron|RGL2_ENST00000437840.2_5'UTR	NM_001243738.1|NM_004761.4	NP_001230667.1|NP_004752.1	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation stimulator-like 2	106	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			breast(2)|cervix(2)|endometrium(7)|kidney(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	34						TGTCCGGGTATCCAGTAGGTG	0.612000													22	68					0	0	1	0	0
TBCE	6905	broad.mit.edu	37	1	235600692	235600692	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:235600692T>C	ENST00000543662.1	+	13	1278	c.1172T>C	c.(1171-1173)cTa>cCa	p.L391P	TBCE_ENST00000406207.1_Missense_Mutation_p.L340P|TBCE_ENST00000366601.3_Missense_Mutation_p.L340P|TBCE_ENST00000472011.1_3'UTR			Q15813	TBCE_HUMAN	tubulin folding cofactor E	340					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding			NS(1)|endometrium(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	14	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			TTGTCCTGCCTAAGAAACCCC	0.473000													25	87					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76452267	76452267	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:76452267T>G	ENST00000396423.2	+	1	164	c.40T>G	c.(40-42)Tac>Gac	p.Y14D	HNF4G_ENST00000354370.1_Intron	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	0					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			GGACCCAACTTACACAACTTT	0.348000													46	146					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72739307	72739307	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:72739307A>G	ENST00000340415.3	+	4	1274	c.265A>G	c.(265-267)Acc>Gcc	p.T89A	RAB37_ENST00000392613.5_Missense_Mutation_p.T96A|RAB37_ENST00000392615.5_Missense_Mutation_p.T64A|RAB37_ENST00000392614.4_Missense_Mutation_p.T101A|RAB37_ENST00000392610.1_Missense_Mutation_p.T96A|RAB37_ENST00000528438.1_Missense_Mutation_p.T69A|RAB37_ENST00000392612.3_Missense_Mutation_p.T59A|RAB37_ENST00000402449.4_Missense_Mutation_p.T89A	NM_175738.4	NP_783865.1	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family	96					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	12						CCGAAGCGTCACCCATGCTTA	0.592000													49	141					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20951005	20951005	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:20951005T>C	ENST00000380249.1	+	36	4323	c.3959T>C	c.(3958-3960)gTc>gCc	p.V1320A	FOCAD_ENST00000605086.1_Missense_Mutation_p.V756A|FOCAD_ENST00000338382.6_Missense_Mutation_p.V1320A	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	1320						integral to membrane	binding										GTCATTAGTGTCTCTGGGGTG	0.398000													35	122					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63326018	63326018	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:63326018T>C	ENST00000255695.1	-	3	291	c.233A>G	c.(232-234)aAc>aGc	p.N78S		NM_017878.1	NP_060348.1	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	78					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6						ATCGTGCTTGTTATTGACCCT	0.547000													20	153					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232649899	232649899	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:232649899T>A	ENST00000366630.1	-	2	1545	c.1187A>T	c.(1186-1188)gAt>gTt	p.D396V	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.D396V			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	396					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ATCACCCTCATCGGCATCCAG	0.552000													67	235					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64331799	64331799	+	Missense_Mutation	SNP	C	C	T	rs142048527	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64331799C>T	ENST00000301891.4	+	5	1215	c.841C>T	c.(841-843)Cgg>Tgg	p.R281W	SLC22A11_ENST00000377581.3_Missense_Mutation_p.R281W|SLC22A11_ENST00000490834.1_Intron|SLC22A11_ENST00000377585.3_Missense_Mutation_p.R281W	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	281					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	AGAATCCGCCCGGTGGCTGAT	0.602000													19	65					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149511679	149511679	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:149511679A>G	ENST00000258484.6	+	4	677	c.643A>G	c.(643-645)Aca>Gca	p.T215A		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	215					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		TCGGAGAAGAACAGAGAAAAT	0.368000													5	13					0	0	1	0	0
FAM217B	63939	broad.mit.edu	37	20	58519670	58519670	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:58519670T>C	ENST00000358293.3	+	5	1087	c.672T>C	c.(670-672)agT>agC	p.S224S	FAM217B_ENST00000469084.1_3'UTR|FAM217B_ENST00000360816.3_Silent_p.S224S	NM_001190826.1	NP_001177755.1	Q9NTX9	CT177_HUMAN	family with sequence similarity 217, member B	224																	CTGGGAGAAGTAAGCTAATTG	0.537000													24	71					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23299746	23299746	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:23299746A>G	ENST00000258733.4	+	5	984	c.689A>G	c.(688-690)tAc>tGc	p.Y230C	GPNMB_ENST00000453162.2_Missense_Mutation_p.Y172C|GPNMB_ENST00000381990.2_Missense_Mutation_p.Y230C|GPNMB_ENST00000539136.1_Missense_Mutation_p.Y131C			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	230					negative regulation of cell proliferation	melanosome		p.Y230F(1)		breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			AAAGATGTGTACGTGGTAACA	0.478000													27	88					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171406539	171406539	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:171406539T>C	ENST00000356327.5	-	14	1536	c.1466A>G	c.(1465-1467)gAc>gGc	p.D489G	PLD1_ENST00000351298.4_Missense_Mutation_p.D489G|PLD1_ENST00000342215.6_Missense_Mutation_p.D489G|PLD1_ENST00000340989.4_Missense_Mutation_p.D489G	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	489	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GTGCTCATTGTCGTCCCACCT	0.512000													32	92					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52618702	52618702	+	Missense_Mutation	SNP	C	C	T	rs150574210		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:52618702C>T	ENST00000600228.1	-	4	1976	c.1715G>A	c.(1714-1716)aGt>aAt	p.S572N	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TTTCTCTCCACTATGAATTCT	0.428000													18	40					0	0	1	0	0
SMPD1	6609	broad.mit.edu	37	11	6414558	6414558	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:6414558G>A	ENST00000342245.4	+	3	1372	c.1204G>A	c.(1204-1206)Gca>Aca	p.A402T	SMPD1_ENST00000527275.1_Missense_Mutation_p.A401T|SMPD1_ENST00000356761.2_Intron|SMPD1_ENST00000299397.3_Intron	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	400					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CACGGATCCCGCAGGACAGCT	0.562000													12	35					0	0	1	0	0
ASPN	54829	broad.mit.edu	37	9	95237107	95237107	+	Missense_Mutation	SNP	C	C	T	rs146516859		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:95237107C>T	ENST00000375544.3	-	2	316	c.73G>A	c.(73-75)Gca>Aca	p.A25T	ASPN_ENST00000395538.3_Missense_Mutation_p.A25T|ASPN_ENST00000375543.1_Missense_Mutation_p.A25T|CENPP_ENST00000375587.3_Intron|ASPN_ENST00000450139.2_5'UTR	NM_017680.4	NP_060150.4	Q9BXN1	ASPN_HUMAN	asporin	25					bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9						TTCTTCAGTGCGATGTGTGAA	0.423000													10	36					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9011372	9011372	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9011372A>T	ENST00000397910.4	-	36	39064	c.38861T>A	c.(38860-38862)aTc>aAc	p.I12954N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12956	SEA 6.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGCTCTTTGATGCCATGGGT	0.552000													108	275					0	0	1	0	0
HARS	3035	broad.mit.edu	37	5	140054660	140054660	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140054660T>C	ENST00000504366.1	-	10	2865	c.1046A>G	c.(1045-1047)aAg>aGg	p.K349R	HARS_ENST00000448240.1_Missense_Mutation_p.K223R|HARS_ENST00000415192.2_Missense_Mutation_p.K344R|HARS_ENST00000307633.3_Missense_Mutation_p.K358R|HARS_ENST00000457527.2_Missense_Mutation_p.K398R|HARS_ENST00000431330.2_Missense_Mutation_p.K304R|HARS_ENST00000504156.1_Missense_Mutation_p.K418R|HARS_ENST00000438307.2_Missense_Mutation_p.K378R			P12081	SYHC_HUMAN	histidyl-tRNA synthetase	418					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	TAGCAGCTTCTTCTGTGCAGA	0.537000													31	89					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144354770	144354770	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:144354770T>C	ENST00000262995.4	+	3	921	c.494T>C	c.(493-495)aTc>aCc	p.I165T	GAB1_ENST00000505913.1_Missense_Mutation_p.I62T|GAB1_ENST00000262994.4_Missense_Mutation_p.I165T	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	165					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					TATCAGCTAATCAATGTTCCA	0.478000													5	117					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39760881	39760881	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:39760881A>G	ENST00000395670.3	-	5	1105	c.686T>C	c.(685-687)aTt>aCt	p.I229T	KIF21A_ENST00000361418.5_Missense_Mutation_p.I229T|KIF21A_ENST00000541463.2_Missense_Mutation_p.I229T|KIF21A_ENST00000544797.2_Missense_Mutation_p.I229T|KIF21A_ENST00000361961.3_Missense_Mutation_p.I229T			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	229	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				AATGGTAAAAATGGCATGTGA	0.393000													19	102					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6361008	6361008	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:6361008G>A	ENST00000262483.8	-	19	2612	c.2525C>T	c.(2524-2526)aCg>aTg	p.T842M	ACKR6_ENST00000421306.3_Missense_Mutation_p.T806M|ACKR6_ENST00000576664.1_5'UTR	NM_031220.3	NP_112497.2																					GATGTCCTTCGTGGAGCCATA	0.602000													3	16					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1272562	1272562	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1272562A>T	ENST00000447027.1	+	31	14519	c.14461A>T	c.(14461-14463)Atc>Ttc	p.I4821F	MUC5B_ENST00000529681.1_Missense_Mutation_p.I4818F			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4818	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GACGACCCGGATCCTCACTGA	0.627000													45	148					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3438901	3438901	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:3438901G>A	ENST00000301365.4	-	7	881	c.750C>T	c.(748-750)ttC>ttT	p.F250F	TRPV3_ENST00000572519.1_Silent_p.F250F|TRPV3_ENST00000576742.1_Silent_p.F250F			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	250						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	ACTTGGGGTTGAAGAAGGCCC	0.692000													11	31					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130381066	130381066	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:130381066A>G	ENST00000358511.6	+	34	6447	c.6416A>G	c.(6415-6417)cAc>cGc	p.H2139R	COL6A6_ENST00000453409.2_Missense_Mutation_p.H2139R	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2139	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CCTTTGGATCACCACCTGGTC	0.458000													44	159					0	0	1	0	0
POU2F1	5451	broad.mit.edu	37	1	167345366	167345366	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:167345366T>A	ENST00000367862.5	+	7	894	c.659T>A	c.(658-660)aTc>aAc	p.I220N	POU2F1_ENST00000429375.2_Missense_Mutation_p.I168N|POU2F1_ENST00000367866.2_Missense_Mutation_p.I231N|POU2F1_ENST00000420254.3_Missense_Mutation_p.I208N|POU2F1_ENST00000367865.1_3'UTR|POU2F1_ENST00000452019.1_Missense_Mutation_p.I208N|POU2F1_ENST00000541643.3_Missense_Mutation_p.I208N	NM_001198783.1	NP_001185712.1	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	208					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	30						CAGTTTATCATCTCACAGACG	0.483000													15	68					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27845553	27845553	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27845553G>C	ENST00000318304.8	+	28	3196	c.2913G>C	c.(2911-2913)caG>caC	p.Q971H	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.Q940H|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.Q965H|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.Q818H	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	971					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					CAGTGAGACAGATAGGTGCAT	0.373000													22	175					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258765	56258765	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:56258765T>C	ENST00000327216.2	-	1	106	c.82A>G	c.(82-84)Acg>Gcg	p.T28A		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					AGAAACAGCGTGAAGAGGAGA	0.502000													56	134					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													8	135					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44419190	44419190	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:44419190T>C	ENST00000269973.5	-	10	1488	c.398A>G	c.(397-399)gAa>gGa	p.E133G	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Missense_Mutation_p.E133G	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	133					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						ATCTCGTTTTTCCAACTGGCA	0.403000													15	58					0	0	1	0	0
HOXA6	3203	broad.mit.edu	37	7	27185535	27185535	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:27185535A>G	ENST00000222728.3	-	2	468	c.442_splice	c.e2-1	p.G148_splice	HOXA-AS3_ENST00000521197.1_RNA|HOXA3_ENST00000467897.2_Intron|HOXA6_ENST00000521478.1_5'UTR|HOXA-AS3_ENST00000518848.1_RNA	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	148						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						CATACACAGCACCTACGAGCA	0.632000													34	107					0	0	1	0	0
C11orf24	53838	broad.mit.edu	37	11	68029987	68029987	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:68029987C>T	ENST00000304271.6	-	4	878	c.476G>A	c.(475-477)aGc>aAc	p.S159N	C11orf24_ENST00000533310.1_Intron|C11orf24_ENST00000530166.1_5'UTR	NM_022338.3	NP_071733.1	Q96F05	CK024_HUMAN	chromosome 11 open reading frame 24	159						integral to membrane				endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)	13						CATGGGAGTGCTGGAGGCCGC	0.637000													16	34					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43017324	43017324	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:43017324T>C	ENST00000535468.1	-	7	1984	c.1898A>G	c.(1897-1899)cAg>cGg	p.Q633R	CUL7_ENST00000265348.3_Missense_Mutation_p.Q549R	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	549					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ATTGAGTCGCTGTGGCAGAGT	0.542000													23	78					0	0	1	0	0
HIAT1	64645	broad.mit.edu	37	1	100534140	100534140	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:100534140C>G	ENST00000370152.3	+	7	953	c.817C>G	c.(817-819)Cag>Gag	p.Q273E	RP4-714D9.2_ENST00000432294.1_RNA	NM_033055.2	NP_149044.2	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	273					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		ATACCTCAGACAGGTAAAATC	0.393000													22	94					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17744917	17744917	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:17744917G>A	ENST00000380060.3	+	6	2966	c.2628G>A	c.(2626-2628)acG>acA	p.T876T	NHS_ENST00000398097.3_Silent_p.T720T	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	876						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					TCGCCAACACGCCTTCTCGAA	0.473000													39	54					0	0	1	0	0
C14orf166B	145497	broad.mit.edu	37	14	77294742	77294742	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:77294742A>G	ENST00000393774.3	+	2	321	c.197A>G	c.(196-198)gAa>gGa	p.E66G	C14orf166B_ENST00000216453.5_Missense_Mutation_p.E23G|C14orf166B_ENST00000460005.1_3'UTR|C14orf166B_ENST00000450042.2_Missense_Mutation_p.E49G	NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	66										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		GAGAATTCGGAAACAGACCTG	0.522000													36	104					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109357008	109357008	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:109357008C>A	ENST00000283195.6	+	7	972	c.846C>A	c.(844-846)ttC>ttA	p.F282L		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	282					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CAGCTACTTTCTTAGAAATGA	0.378000													86	299					7.49063e-41	7.94504e-41	1	1	0
JARID2	3720	broad.mit.edu	37	6	15497123	15497123	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:15497123A>T	ENST00000341776.2	+	7	1911	c.1667A>T	c.(1666-1668)gAg>gTg	p.E556V	JARID2_ENST00000541660.1_Missense_Mutation_p.E518V|JARID2_ENST00000397311.3_Missense_Mutation_p.E384V	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	556					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GCCATGGACGAGATCCCCGTC	0.652000													10	25					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35376184	35376184	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35376184G>A	ENST00000378495.3	+	14	1750	c.1528G>A	c.(1528-1530)Gaa>Aaa	p.E510K	UNC13B_ENST00000378496.4_Missense_Mutation_p.E510K|UNC13B_ENST00000396787.1_Missense_Mutation_p.E522K	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	510					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GCGCTGCAGCGAATGTGGAGT	0.612000													37	132					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197184031	197184031	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:197184031T>C	ENST00000260983.2	-	9	1765	c.1583A>G	c.(1582-1584)gAt>gGt	p.D528G	HECW2_ENST00000409111.1_Missense_Mutation_p.D172G	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	528					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TTCTGGCTTATCCTCAAAGGA	0.552000													7	60					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98457952	98457952	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:98457952A>G	ENST00000450876.1	-	3	1464	c.149T>C	c.(148-150)gTg>gCg	p.V50A	TMEM130_ENST00000339375.4_Missense_Mutation_p.V134A|TMEM130_ENST00000546258.1_Missense_Mutation_p.V115A|TMEM130_ENST00000416379.2_Missense_Mutation_p.V134A|TMEM130_ENST00000345589.4_Missense_Mutation_p.V32A			Q8N3G9	TM130_HUMAN	transmembrane protein 130	134						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAGGTCCCCCACGAGGAACTC	0.567000													14	37					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207868064	207868064	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:207868064A>G	ENST00000508064.2	+	5	890	c.830A>G	c.(829-831)aAa>aGa	p.K277R	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	277	Sushi 4.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GCCCTGAACAAATGGGAGCCA	0.512000													4	199					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712409	121712409	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:121712409T>C	ENST00000273691.3	-	6	1160	c.1055A>G	c.(1054-1056)gAc>gGc	p.D352G	ILDR1_ENST00000393631.1_Missense_Mutation_p.D307G|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000344209.5_Missense_Mutation_p.D396G|ILDR1_ENST00000462014.1_Missense_Mutation_p.D364G	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	396						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		CCACGATGGGTCCAACTCCCT	0.577000													26	73					0	0	1	0	0
AGPAT2	10555	broad.mit.edu	37	9	139571444	139571444	+	Missense_Mutation	SNP	G	G	A	rs150530734	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139571444G>A	ENST00000371696.2	-	3	526	c.461C>T	c.(460-462)gCc>gTc	p.A154V	AGPAT2_ENST00000371694.3_Missense_Mutation_p.A154V|AGPAT2_ENST00000538402.1_Missense_Mutation_p.A154V	NM_006412.3	NP_006403.2	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	154					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			endometrium(1)|large_intestine(1)|lung(2)|prostate(2)	6	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GCCCAGGTCGGCCATCACTGT	0.687000													4	157					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5423449	5423449	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:5423449T>C	ENST00000341928.2	-	11	1607	c.1267A>G	c.(1267-1269)Ata>Gta	p.I423V	EPB41L3_ENST00000544123.1_Missense_Mutation_p.I423V|EPB41L3_ENST00000540638.2_Missense_Mutation_p.I423V|EPB41L3_ENST00000400111.3_Missense_Mutation_p.I423V|EPB41L3_ENST00000342933.3_Missense_Mutation_p.I423V|EPB41L3_ENST00000542652.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	423	Hydrophilic.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GGGCGATCTATCAACGCACTG	0.488000													21	54					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180745	65180745	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:65180745G>A	ENST00000310045.7	-	2	2604	c.1131C>T	c.(1129-1131)caC>caT	p.H377H	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	367						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				CTTTAGGTCGGTGCTTTCTAA	0.438000													28	80					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45855501	45855501	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45855501T>C	ENST00000391945.4	-	22	2233	c.2156A>G	c.(2155-2157)tAc>tGc	p.Y719C	ERCC2_ENST00000391944.3_Missense_Mutation_p.Y641C	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	719			Missing (in XP-D and TTDP).		cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCGCAGGAAGTACTTGGCCAC	0.662000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				27	61					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41452138	41452138	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:41452138T>C	ENST00000400454.1	-	25	4838	c.4361A>G	c.(4360-4362)cAa>cGa	p.Q1454R		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1454	Fibronectin type-III 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CACTCCATTTTGGGCTGTCAG	0.458000													14	125					0	0	1	0	0
YY1	7528	broad.mit.edu	37	14	100743827	100743827	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:100743827G>A	ENST00000262238.4	+	5	1395	c.1135G>A	c.(1135-1137)Gga>Aga	p.G379R		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	379	Involved in masking transactivation domain.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				AATCCATACCGGAGACAGGCC	0.468000													32	76					0	0	1	0	0
FAM214B	80256	broad.mit.edu	37	9	35106373	35106373	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35106373C>T	ENST00000378561.1	-	5	4149	c.1094G>A	c.(1093-1095)gGc>gAc	p.G365D	FAM214B_ENST00000488109.2_Missense_Mutation_p.G365D|FAM214B_ENST00000378566.1_Missense_Mutation_p.G60D|FAM214B_ENST00000603301.1_Missense_Mutation_p.G365D|FAM214B_ENST00000378557.1_Missense_Mutation_p.G365D|FAM214B_ENST00000322813.5_Missense_Mutation_p.G365D|FAM214B_ENST00000605244.1_Missense_Mutation_p.G365D|FAM214B_ENST00000378554.2_Missense_Mutation_p.G365D			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	365						nucleus											CTCAATGTGGCCAGATGGTGC	0.493000													15	66					0	0	1	0	0
IMPACT	55364	broad.mit.edu	37	18	22025367	22025367	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:22025367T>C	ENST00000284202.4	+	8	746	c.605T>C	c.(604-606)gTt>gCt	p.V202A		NM_018439.3	NP_060909.1	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein	202										endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					GTGAAAATGGTTCTTTCCAAA	0.313000													17	45					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197030932	197030932	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:197030932T>C	ENST00000367412.1	-	3	476	c.433A>G	c.(433-435)Acc>Gcc	p.T145A		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	145	Sushi 2.				blood coagulation	extracellular region		p.T145A(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TTCCTACAGGTTGGTTGAGAA	0.373000													10	46					0	0	1	0	0
ZNF76	7629	broad.mit.edu	37	6	35260407	35260407	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:35260407C>T	ENST00000373953.3	+	10	1274	c.1008C>T	c.(1006-1008)caC>caT	p.H336H	ZNF76_ENST00000440666.2_Silent_p.H310H|ZNF76_ENST00000339411.5_Silent_p.H336H	NM_003427.3	NP_003418.2	P36508	ZNF76_HUMAN	zinc finger protein 76	336					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						ATAAGCACCACGTGGTGCACA	0.627000													25	86					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248750	20248750	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20248750A>G	ENST00000315957.4	+	1	350	c.269A>G	c.(268-270)aAg>aGg	p.K90R		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGAGAGGAAGATAATTTCC	0.443000													9	648					0	0	1	0	0
HP1BP3	50809	broad.mit.edu	37	1	21074117	21074117	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:21074117G>A	ENST00000375003.2	-	7	2217	c.717C>T	c.(715-717)tgC>tgT	p.C239C	HP1BP3_ENST00000312239.5_Silent_p.C391C			Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	391					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		CATTCTTTTCGCATTTCTGCA	0.383000													10	42					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141607801	141607801	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:141607801A>G	ENST00000389484.3	-	29	5780	c.4809T>C	c.(4807-4809)ccT>ccC	p.P1603P		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1603					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATCAATATCAGGGACTGTAA	0.348000										TSP Lung(27;0.18)			19	49					0	0	1	0	0
STAG3L4	64940	broad.mit.edu	37	7	66767852	66767852	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:66767852C>T	ENST00000416602.2	+	0	245					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				CGGCCCAGCGCCCGGCGTTGG	0.726000													6	9					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116603660	116603660	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:116603660C>T	ENST00000369248.4	+	7	1312	c.977C>T	c.(976-978)cCg>cTg	p.P326L	FAM160B1_ENST00000369250.3_Missense_Mutation_p.P326L	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	326										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						TCAGTGGATCCGTTAGATATT	0.458000													26	103					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551319	248551319	+	Missense_Mutation	SNP	G	G	A	rs2226010		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248551319G>A	ENST00000355728.2	+	1	410	c.410G>A	c.(409-411)aGc>aAc	p.S137N		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCCTCATCAGCTGGCGGGTC	0.577000													19	64					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65561814	65561814	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:65561814G>A	ENST00000356388.4	-	3	487	c.298C>T	c.(298-300)Ctt>Ttt	p.L100F	SPRED2_ENST00000474228.1_5'UTR|SPRED2_ENST00000443619.2_Missense_Mutation_p.L97F	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	100	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding	p.L100F(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						TGGAAAGTAAGTCCAAACTTC	0.448000													47	147					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42436233	42436233	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:42436233A>G	ENST00000397272.3	-	18	2182	c.2091T>C	c.(2089-2091)ccT>ccC	p.P697P	PLA2G4F_ENST00000382396.4_Silent_p.P695P	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	695	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CTGCTCTCTGAGGCAGCAGAG	0.602000													25	104					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179429620	179429620	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179429620A>G	ENST00000589042.1	-	326	81463	c.81239T>C	c.(81238-81240)tTt>tCt	p.F27080S	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.F18015S|TTN_ENST00000342992.6_Missense_Mutation_p.F24512S|TTN_ENST00000591111.1_Missense_Mutation_p.F25439S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.F18140S|TTN_ENST00000342175.6_Missense_Mutation_p.F18207S|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25439	Fibronectin type-III 97.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGTCACAAAAGGAGTTCC	0.403000													16	56					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754749	140754749	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140754749G>A	ENST00000517434.1	+	1	1099	c.1099G>A	c.(1099-1101)Gcc>Acc	p.A367T	PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACAGTAATCGCCCTTTTTCA	0.433000													35	114					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56716461	56716461	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56716461G>A	ENST00000425394.2	-	18	2963	c.2587C>T	c.(2587-2589)Cgc>Tgc	p.R863C	PAN2_ENST00000257931.5_Missense_Mutation_p.R862C|PAN2_ENST00000548043.1_Missense_Mutation_p.R863C|PAN2_ENST00000440411.3_Missense_Mutation_p.R859C	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	863					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CCCCCTGTGCGTGAGTCCAGG	0.592000													50	86					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60173352	60173352	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:60173352G>C	ENST00000261187.4	+	5	1493	c.1329G>C	c.(1327-1329)caG>caC	p.Q443H	SLC16A7_ENST00000552432.1_Missense_Mutation_p.Q443H|SLC16A7_ENST00000547379.1_Missense_Mutation_p.Q443H|SLC16A7_ENST00000543448.1_Missense_Mutation_p.Q344H|SLC16A7_ENST00000552024.1_Missense_Mutation_p.Q443H	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	443						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATGCAAGGCAGAAGACCAGAG	0.433000													15	26					0	0	1	0	0
KIF11	3832	broad.mit.edu	37	10	94353185	94353185	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:94353185A>G	ENST00000260731.3	+	1	143	c.53A>G	c.(52-54)aAc>aGc	p.N18S		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	18	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAGGGGAAGAACATCCAGGTG	0.637000													7	31					0	0	1	0	0
HDAC3	8841	broad.mit.edu	37	5	141009296	141009296	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:141009296A>G	ENST00000305264.3	-	6	510	c.431T>C	c.(430-432)tTc>tCc	p.F144S		NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	144	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	GACATAGCAGAAGCCAGAGGC	0.542000													8	154					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5067889	5067889	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5067889C>T	ENST00000380370.1	+	1	134	c.134C>T	c.(133-135)gCc>gTc	p.A45V		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGGGCAATGCCACCATTCTG	0.493000													19	65					0	0	1	0	0
DDX59	83479	broad.mit.edu	37	1	200635318	200635318	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:200635318T>C	ENST00000447706.2	-	2	702	c.551A>G	c.(550-552)aAt>aGt	p.N184S	DDX59_ENST00000331314.6_Missense_Mutation_p.N184S|DDX59_ENST00000367348.3_Missense_Mutation_p.N184S			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	184						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						CTGTTTAAGATTTTCAATCTG	0.433000													7	159					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7700509	7700509	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:7700509A>G	ENST00000303635.7	+	7	767	c.560A>G	c.(559-561)gAc>gGc	p.D187G	CAMTA1_ENST00000439411.2_Missense_Mutation_p.D187G	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCCATCGAGGACTGCGGCAAG	0.612000			T	WWTR1	epitheliod hemangioendothelioma								4	142					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233944059	233944059	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233944059T>C	ENST00000359570.5	+	2	149	c.149T>C	c.(148-150)gTt>gCt	p.V50A	INPP5D_ENST00000538935.1_Missense_Mutation_p.V50A			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	50	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CGGAATTGCGTTTACACTTAC	0.408000													9	63					0	0	1	0	0
RP11-159L20.2	0	broad.mit.edu	37	14	31290756	31290756	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:31290756G>A	ENST00000554665.1	-	0	208																											CGCCCCTACAGCCATGCCCTG	0.498000													27	54					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3141689	3141689	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:3141689G>A	ENST00000263650.7	-	6	727	c.568C>T	c.(568-570)Ctc>Ttc	p.L190F	OSBPL5_ENST00000348039.5_Intron|OSBPL5_ENST00000542243.1_Intron|OSBPL5_ENST00000525498.1_Intron|OSBPL5_ENST00000389989.3_Intron	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	190	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGGTGGAAGAGCTTGAAGCAG	0.647000													13	56					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92085904	92085904	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:92085904C>T	ENST00000298047.6	+	1	643	c.626C>T	c.(625-627)aCg>aTg	p.T209M	FAT3_ENST00000409404.2_Missense_Mutation_p.T209M|FAT3_ENST00000541502.1_Missense_Mutation_p.T209M|FAT3_ENST00000525166.1_Missense_Mutation_p.T59M			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	209	Cadherin 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTTCACCCCACGAGTGGTGTC	0.408000										TCGA Ovarian(4;0.039)			25	57					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101716889	101716889	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:101716889G>A	ENST00000342239.3	-	4	433	c.342C>T	c.(340-342)ggC>ggT	p.G114G	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Silent_p.G114G			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	114	SH3 2.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		ATGGGAAGAAGCCCCGTGCGC	0.592000													14	56					0	0	1	0	0
TPI1	7167	broad.mit.edu	37	12	6979496	6979496	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6979496T>C	ENST00000229270.4	+	7	1147	c.810T>C	c.(808-810)ggT>ggC	p.G270G	TPI1_ENST00000488464.2_Silent_p.G151G|TPI1_ENST00000535434.1_Silent_p.G151G|TPI1_ENST00000396705.5_Silent_p.G233G	NM_001159287.1	NP_001152759.1	P60174	TPIS_HUMAN	triosephosphate isomerase 1	233					fatty acid biosynthetic process|gluconeogenesis|glycolysis|pentose-phosphate shunt	cytosol	triose-phosphate isomerase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|skin(2)	19						TCCTTGTGGGTGGTGCTTCCC	0.577000											OREG0021638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	76					0	0	1	0	0
MGAT1	4245	broad.mit.edu	37	5	180219557	180219557	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:180219557C>T	ENST00000446023.2	-	3	1165	c.415G>A	c.(415-417)Gtt>Att	p.V139I	MGAT1_ENST00000393340.3_Missense_Mutation_p.V139I|MGAT1_ENST00000333055.3_Missense_Mutation_p.V139I|MGAT1_ENST00000427865.2_Missense_Mutation_p.V139I|MGAT1_ENST00000307826.4_Missense_Mutation_p.V139I	NM_001114617.1|NM_001114618.1	NP_001108089.1|NP_001108090.1	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	139					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			endometrium(1)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	13	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCTGGCTAACGATGATGGGG	0.652000													16	75					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25967275	25967275	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:25967275A>G	ENST00000435504.4	-	13	2224	c.1931T>C	c.(1930-1932)gTc>gCc	p.V644A	ASXL2_ENST00000272341.4_Missense_Mutation_p.V384A|ASXL2_ENST00000336112.4_Missense_Mutation_p.V616A|ASXL2_ENST00000404843.1_Missense_Mutation_p.V384A			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTGATGGAGACTGGAAAACG	0.527000													23	61					0	0	1	0	0
PRKAB1	5564	broad.mit.edu	37	12	120112225	120112225	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120112225A>G	ENST00000229328.5	+	4	990	c.498A>G	c.(496-498)ttA>ttG	p.L166L	PRKAB1_ENST00000541640.1_Silent_p.L166L|PRKAB1_ENST00000540121.1_5'UTR	NM_006253.4	NP_006244.2	Q9Y478	AAKB1_HUMAN	protein kinase, AMP-activated, beta 1 non-catalytic subunit	166					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol				endometrium(2)|large_intestine(3)|lung(5)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	TTGATGCTTTAATGGTGGATT	0.438000													18	105					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54930385	54930385	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54930385C>T	ENST00000301194.4	+	2	332	c.210C>T	c.(208-210)tgC>tgT	p.C70C	TTYH1_ENST00000391739.3_Silent_p.C119C|TTYH1_ENST00000376530.3_Silent_p.C70C|TTYH1_ENST00000376531.3_Silent_p.C70C			Q9H313	TTYH1_HUMAN	tweety family member 1	70					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TCCGCTTCTGCTGCTGCCGGC	0.682000													19	133					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38129023	38129023	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:38129023C>T	ENST00000339363.3	-	18	3086	c.2919G>A	c.(2917-2919)ccG>ccA	p.P973P	RPGR_ENST00000309513.3_Silent_p.P706P|RPGR_ENST00000338898.3_3'UTR|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000318842.7_Silent_p.P768P			Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	973					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding	p.P768P(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						TCTCTGGGAGCGGCTCATTGT	0.358000													21	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179426382	179426382	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179426382A>G	ENST00000589042.1	-	326	84701	c.84477T>C	c.(84475-84477)ggT>ggC	p.G28159G	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Silent_p.G19094G|TTN_ENST00000342992.6_Silent_p.G25591G|TTN_ENST00000591111.1_Silent_p.G26518G|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000359218.5_Silent_p.G19219G|TTN_ENST00000342175.6_Silent_p.G19286G|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26518	Fibronectin type-III 105.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTAGGAGTACCAGGAGGAC	0.463000													12	28					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664056	22664056	+	RNA	SNP	T	T	C	rs3178309		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:22664056T>C	ENST00000426066.1	+	0	623					NR_027293.1																						ATAAAGTATATGATTTTGTGT	0.348000													15	45					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116948931	116948931	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:116948931G>A	ENST00000229554.5	+	3	1198	c.1061G>A	c.(1060-1062)cGc>cAc	p.R354H	RSPH4A_ENST00000368581.4_Missense_Mutation_p.R354H|RSPH4A_ENST00000368580.4_Intron	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	354					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CAAAGATGCCGCTTCTGGGGA	0.448000									Kartagener syndrome				15	114					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233274406	233274406	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233274406A>T	ENST00000295453.3	+	11	1475	c.1423A>T	c.(1423-1425)Acc>Tcc	p.T475S		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	475					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GCAGGAGCAGACCTTCATAGC	0.741000													8	34					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116225582	116225582	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:116225582T>C	ENST00000533213.2	-	12	1437	c.1136A>G	c.(1135-1137)tAc>tGc	p.Y379C	ABLIM1_ENST00000369253.2_Missense_Mutation_p.Y97C|ABLIM1_ENST00000369266.3_Missense_Mutation_p.Y151C|ABLIM1_ENST00000369252.4_Missense_Mutation_p.Y379C|ABLIM1_ENST00000392952.3_Missense_Mutation_p.Y151C|ABLIM1_ENST00000277895.5_Missense_Mutation_p.Y439C			O14639	ABLM1_HUMAN	actin binding LIM protein 1	439					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		AACATCCTGGTACCCCTGGAA	0.537000													44	136					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105363403	105363403	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:105363403C>T	ENST00000369774.4	-	15	1848	c.1572G>A	c.(1570-1572)ccG>ccA	p.P524P	SH3PXD2A_ENST00000540321.1_Silent_p.P391P|SH3PXD2A_ENST00000538130.1_Silent_p.P359P|SH3PXD2A_ENST00000355946.2_Silent_p.P496P|SH3PXD2A_ENST00000427662.2_Intron|SH3PXD2A_ENST00000315994.6_5'UTR			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	524					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GGGGTGCTGGCGGGGGCACCT	0.672000													6	51					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42604929	42604929	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:42604929G>A	ENST00000372899.1	+	15	2113	c.1855G>A	c.(1855-1857)Gca>Aca	p.A619T	UBR2_ENST00000372883.3_Missense_Mutation_p.A123T|UBR2_ENST00000372901.1_Missense_Mutation_p.A619T	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	619					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TCGCTTACTTGCAGGTAAAGC	0.353000													18	58					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603627	140603627	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140603627G>A	ENST00000239449.4	+	1	550	c.550G>A	c.(550-552)Gac>Aac	p.D184N	PCDHB14_ENST00000515856.2_Missense_Mutation_p.D31N	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		184	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAAAATTCCCGACAGTAGTGA	0.418000													27	95					0	0	1	0	0
C4orf27	54969	broad.mit.edu	37	4	170671806	170671806	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:170671806C>T	ENST00000393381.2	-	3	354	c.279G>A	c.(277-279)acG>acA	p.T93T		NM_017867.2	NP_060337.2	Q9NWY4	CD027_HUMAN	chromosome 4 open reading frame 27	93						nucleus				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	12		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)		ATTTTTTCTTCGTTTTATGTT	0.333000													42	152					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112194271	112194271	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112194271C>T	ENST00000455480.2	+	22	3444	c.3267C>T	c.(3265-3267)cgC>cgT	p.R1089R	ACAD10_ENST00000313698.4_Silent_p.R1058R|RP11-162P23.2_ENST00000546840.2_Intron	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	1058							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						TGAAGCACCGCATTTAGAGCC	0.622000													11	28					0	0	1	0	0
LUC7L	55692	broad.mit.edu	37	16	249183	249183	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:249183C>T	ENST00000337351.4	-	6	688	c.565G>A	c.(565-567)Gtc>Atc	p.V189I	LUC7L_ENST00000397783.1_Missense_Mutation_p.V189I|LUC7L_ENST00000293872.8_Missense_Mutation_p.V189I|LUC7L_ENST00000397780.1_Missense_Mutation_p.V136I	NM_018032.3	NP_060502.1	Q9NQ29	LUC7L_HUMAN	LUC7-like (S. cerevisiae)	189							metal ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	11		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				ACCTCGCAGACACGCAGCTTT	0.478000													40	103					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40681477	40681477	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:40681477A>G	ENST00000302472.3	+	2	1406	c.382A>G	c.(382-384)Agc>Ggc	p.S128G	PTGER4_ENST00000514343.1_3'UTR	NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	128					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						CTATTTCTACAGCCACTACGT	0.572000											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	290					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2797785	2797785	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:2797785G>A	ENST00000399655.1	+	46	6222	c.5957G>A	c.(5956-5958)aGc>aAc	p.S1986N	CACNA1C_ENST00000399597.1_Missense_Mutation_p.S1986N|CACNA1C_ENST00000399637.1_Missense_Mutation_p.S2005N|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S1986N|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S1986N|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S1992N|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S1986N|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S2021N|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S2006N|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S2021N|CACNA1C_ENST00000347598.4_Missense_Mutation_p.S2034N|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S2014N|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S2057N|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S2005N|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S2027N|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S1994N|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S2057N|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S2003N|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S1994N|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S2005N|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S1986N|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S2011N	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	2069					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTCAACAGCAGCTTCCCATCC	0.716000													25	120					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41839364	41839364	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:41839364T>C	ENST00000396930.3	-	5	1361	c.818A>G	c.(817-819)aAa>aGa	p.K273R	KAT6A_ENST00000406337.1_Missense_Mutation_p.K273R|KAT6A_ENST00000265713.2_Missense_Mutation_p.K273R|KAT6A_ENST00000485568.1_Missense_Mutation_p.K273R	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	273					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										CACCGCATTTTTGCCTTGATC	0.423000													9	29					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520420	131520420	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:131520420T>A	ENST00000423981.1	+	2	885	c.775T>A	c.(775-777)Tcg>Acg	p.S259T	AMER3_ENST00000321420.4_Missense_Mutation_p.S259T	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AGATGAGAGCTCGGTGCCATC	0.642000													5	113					0	0	1	0	0
AKR1C4	1109	broad.mit.edu	37	10	5242185	5242185	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:5242185A>G	ENST00000380448.1	+	4	379	c.126A>G	c.(124-126)atA>atG	p.I42M	AKR1CL1_ENST00000445191.1_Intron|AKR1C4_ENST00000263126.1_Missense_Mutation_p.I42M			P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	42					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	18					NADH(DB00157)	AATTAGCAATAGAAGCTGGCT	0.448000													30	104					0	0	1	0	0
CELA3A	10136	broad.mit.edu	37	1	22336235	22336235	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22336235A>G	ENST00000290122.3	+	7	699	c.680A>G	c.(679-681)gAt>gGt	p.D227G		NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCCACAGAGGATGGTGGCTGG	0.577000													19	63					0	0	1	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73973362	73973362	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:73973362T>C	ENST00000476977.1	+	21	3970	c.2279T>C	c.(2278-2280)tTc>tCc	p.F760S	GTF2IRD1_ENST00000424337.2_Missense_Mutation_p.F760S|GTF2IRD1_ENST00000265755.3_Missense_Mutation_p.F775S|GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000455841.2_Missense_Mutation_p.F792S			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	775						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AAGATCAAGTTCACAGTCACC	0.567000													6	88					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334212	175334212	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:175334212T>C	ENST00000367674.1	-	12	3229	c.2521A>G	c.(2521-2523)Att>Gtt	p.I841V	TNR_ENST00000263525.2_Missense_Mutation_p.I841V	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	841	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AGGTTCACAATATACTCTGTG	0.567000													4	92					0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44275104	44275104	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:44275104G>A	ENST00000244571.4	-	6	924	c.922C>T	c.(922-924)Cga>Tga	p.R308*	TMEM151B_ENST00000438774.2_3'UTR	NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	308					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	ACCCCTACTCGGCCCAAGTAA	0.632000													9	6					0	0	1	0	0
TMEM135	65084	broad.mit.edu	37	11	86778844	86778844	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:86778844G>A	ENST00000340353.7	+	2	452	c.250G>A	c.(250-252)Gct>Act	p.A84T	TMEM135_ENST00000305494.5_Missense_Mutation_p.A84T|TMEM135_ENST00000532959.1_Intron|TMEM135_ENST00000355734.4_Missense_Mutation_p.A84T|TMEM135_ENST00000535167.1_5'UTR	NM_001168724.1	NP_001162195.1	Q86UB9	TM135_HUMAN	transmembrane protein 135	84						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTTGTATATGGCTTTCTTTTG	0.338000													20	32					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27373961	27373961	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27373961T>C	ENST00000395762.2	+	11	1547	c.1288T>C	c.(1288-1290)Tca>Cca	p.S430P	IL4R_ENST00000380922.3_Missense_Mutation_p.S415P|IL4R_ENST00000543915.2_Missense_Mutation_p.S430P|IL4R_ENST00000170630.2_Missense_Mutation_p.S430P	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	430					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						CATGGGGGAGTCATGCCTTCT	0.617000													35	79					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27691380	27691380	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:27691380T>C	ENST00000493901.1	-	3	603	c.364A>G	c.(364-366)Agc>Ggc	p.S122G	MAP3K6_ENST00000374040.3_Missense_Mutation_p.S122G|MAP3K6_ENST00000357582.2_Missense_Mutation_p.S122G	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	122					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCAGCGAGCTGCTCACCTCC	0.622000													19	56					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183495741	183495741	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:183495741A>G	ENST00000367537.3	+	6	605	c.410A>G	c.(409-411)gAa>gGa	p.E137G	SMG7_ENST00000507469.1_Missense_Mutation_p.E108G|SMG7_ENST00000507406.1_3'UTR|SMG7_ENST00000508461.1_Missense_Mutation_p.E66G|SMG7_ENST00000515829.2_Missense_Mutation_p.E108G|SMG7_ENST00000347615.2_Missense_Mutation_p.E108G|SMG7_ENST00000456731.2_Missense_Mutation_p.E66G			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	108					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TTATTACAAGAACTGTGTACA	0.343000													15	92					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117266652	117266652	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:117266652G>A	ENST00000362057.3	-	1	598	c.430C>T	c.(430-432)Cgg>Tgg	p.R144W	DFNB31_ENST00000374057.3_Missense_Mutation_p.R144W	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219.3	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	144	PDZ 1.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TTGGCACGCCGCAAACTCACC	0.721000													22	63					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71723445	71723445	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:71723445A>G	ENST00000393695.3	-	16	4982		c.e16+1		NUMA1_ENST00000358965.6_Intron|NUMA1_ENST00000351960.6_Intron	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1						G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CTCAGGCATTACCTGCTTAGT	0.547000			T	RARA	APL								21	101					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49631148	49631148	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49631148G>A	ENST00000334186.4	+	2	367	c.18G>A	c.(16-18)atG>atA	p.M6I	PPFIA3_ENST00000602351.1_Missense_Mutation_p.M6I	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	6						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GCGAGGTGATGCCCACCATCA	0.706000													8	31					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49938030	49938030	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49938030T>C	ENST00000257981.6	+	7	1314	c.1054T>C	c.(1054-1056)Tac>Cac	p.Y352H		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	352					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						GCTGGACCGGTACTCGCAGTA	0.672000													5	19					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22835204	22835204	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22835204C>T	ENST00000404138.1	+	9	2190	c.1679C>T	c.(1678-1680)gCc>gTc	p.A560V	ZBTB40_ENST00000375647.4_Missense_Mutation_p.A560V|ZBTB40_ENST00000374651.4_Missense_Mutation_p.A448V	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	560					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GAGCCTGGTGCCGATGCTTTC	0.542000													25	57					0	0	1	0	0
NT5E	4907	broad.mit.edu	37	6	86176945	86176945	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:86176945A>G	ENST00000257770.3	+	2	556	c.507A>G	c.(505-507)gaA>gaG	p.E169E	NT5E_ENST00000369646.3_Silent_p.E169E|NT5E_ENST00000369651.3_Silent_p.E169E	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	169					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	TTGGTGATGAAGTTGTGGGAA	0.378000													4	56					0	0	1	0	0
B3GALT6	126792	broad.mit.edu	37	1	1168029	1168029	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1168029C>T	ENST00000379198.2	+	1	401	c.371C>T	c.(370-372)gCg>gTg	p.A124V		NM_080605.3	NP_542172.2	Q96L58	B3GT6_HUMAN	UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6	124					glycosaminoglycan biosynthetic process|protein glycosylation	Golgi cisterna membrane|Golgi medial cisterna|integral to membrane	galactosylxylosylprotein 3-beta-galactosyltransferase activity			lung(3)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTGCTGCCCGCGCTGCGCGAC	0.736000													16	20					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67080594	67080594	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:67080594T>C	ENST00000284425.2	-	33	4413	c.4239A>G	c.(4237-4239)ttA>ttG	p.L1413L	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1413	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TTCCTGCTGTTAATTTCTGCA	0.443000													10	335					0	0	1	0	0
EFNA1	1942	broad.mit.edu	37	1	155106009	155106009	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:155106009G>A	ENST00000368407.3	+	3	937	c.419G>A	c.(418-420)tGc>tAc	p.C140Y	EFNA1_ENST00000469878.1_3'UTR|EFNA1_ENST00000368406.2_Intron	NM_004428.2	NP_004419.2	P20827	EFNA1_HUMAN	ephrin-A1	140					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding			breast(1)|endometrium(1)|kidney(1)|lung(1)|skin(1)	5	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			GAAGACCGCTGCTTGAGGTTG	0.502000													31	85					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183884283	183884283	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:183884283T>C	ENST00000313143.3	+	9	1201	c.953T>C	c.(952-954)gTa>gCa	p.V318A	DVL3_ENST00000431765.1_Missense_Mutation_p.V318A|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	318	PDZ.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GCAGTCCGGGTACTGCGGGAG	0.537000													56	138					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539284	56539284	+	Missense_Mutation	SNP	G	G	A	rs34175666		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56539284G>A	ENST00000390649.3	+	7	1685	c.1685G>A	c.(1684-1686)cGt>cAt	p.R562H		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	562	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCTGAGCTCCGTGCTCTGTTT	0.542000													8	27					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94679786	94679786	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:94679786T>C	ENST00000371552.4	+	8	881	c.852T>C	c.(850-852)tgT>tgC	p.C284C	EXOC6_ENST00000260762.6_Silent_p.C289C|EXOC6_ENST00000371547.4_Silent_p.C305C|EXOC6_ENST00000443748.2_Intron	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	289					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TTTATCGATGTTTGCACATTT	0.264000													8	26					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811955	140811955	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140811955C>T	ENST00000252085.3	+	1	1771	c.1629C>T	c.(1627-1629)agC>agT	p.S543S	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCCTCAGCAGCAACGTGT	0.622000													88	260					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205027164	205027164	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:205027164C>T	ENST00000331830.4	+	3	470	c.186C>T	c.(184-186)cgC>cgT	p.R62R		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	62	Ig-like C2-type 1.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGGCATGCCGCGCCCGGGCCA	0.637000													9	44					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67546882	67546882	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:67546882T>C	ENST00000310421.4	-	3	3781	c.3523A>G	c.(3523-3525)Act>Gct	p.T1175A		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	1175					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			CAGCCATCAGTTGTTTCTGTA	0.448000													39	156					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188332546	188332546	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:188332546T>C	ENST00000233156.3	-	7	1036	c.742A>G	c.(742-744)Agt>Ggt	p.S248G	AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|TFPI_ENST00000392365.1_Missense_Mutation_p.S248G	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	248	BPTI/Kunitz inhibitor 3.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	CCACATCCACTGTACTTAAAT	0.408000													27	93					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150069682	150069682	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150069682G>A	ENST00000397281.2	+	4	1841	c.1352G>A	c.(1351-1353)cGc>cAc	p.R451H	REPIN1_ENST00000489432.2_Missense_Mutation_p.R508H|REPIN1_ENST00000444957.1_Missense_Mutation_p.R451H|REPIN1_ENST00000425389.2_Missense_Mutation_p.R451H|REPIN1_ENST00000540729.1_Missense_Mutation_p.R451H|REPIN1_ENST00000479668.1_3'UTR	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	451				R -> P (in Ref. 1; AAF26712).	DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCGCATCGGCGCGACCACGCC	0.741000													9	43					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24965979	24965979	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:24965979G>A	ENST00000289968.6	-	10	866	c.797C>T	c.(796-798)gCg>gTg	p.A266V	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Missense_Mutation_p.A266V	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	266	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		AATGGGCAGCGCAATCTCGCG	0.547000													70	205					0	0	1	0	0
IL20RA	53832	broad.mit.edu	37	6	137338204	137338204	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:137338204T>C	ENST00000316649.5	-	2	360	c.125A>G	c.(124-126)aAc>aGc	p.N42S	IL20RA_ENST00000367748.1_5'UTR|IL20RA_ENST00000541547.1_5'UTR|IL20RA_ENST00000468393.1_5'UTR|IL20RA_ENST00000367746.3_Missense_Mutation_p.N42S	NM_014432.2	NP_055247.2	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha	42	Fibronectin type-III 1.					integral to membrane	receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		GAAGGTGATGTTTGCAGGTTT	0.418000													3	59					0	0	1	0	0
LACTB	114294	broad.mit.edu	37	15	63419875	63419875	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:63419875G>A	ENST00000413507.2	+	4	978	c.939G>A	c.(937-939)ttG>ttA	p.L313L	LACTB_ENST00000261893.4_Silent_p.L313L|RPS27L_ENST00000559763.1_Intron	NM_171846.2	NP_741982.1	P83111	LACTB_HUMAN	lactamase, beta	313						mitochondrion	hydrolase activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(1)	12						ATGATCCTTTGTTCTTCAAAC	0.313000													4	26					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27353644	27353644	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:27353644A>G	ENST00000429845.2	-	9	876	c.514T>C	c.(514-516)Tac>Cac	p.Y172H	NEK10_ENST00000341435.5_Missense_Mutation_p.Y172H			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	172							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TAGCCGAGGTACTCATTGGCT	0.478000													9	22					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855702	53855702	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53855702A>G	ENST00000458035.1	+	4	1891	c.1774A>G	c.(1774-1776)Aca>Gca	p.T592A	ZNF845_ENST00000595091.1_Missense_Mutation_p.T592A	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	592					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAGTAATGCTACAACCATTGC	0.378000													3	48					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46726410	46726410	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:46726410C>T	ENST00000371975.4	+	7	1163	c.489C>T	c.(487-489)ttC>ttT	p.F163F	RAD54L_ENST00000442598.1_Silent_p.F163F	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	163					meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		GAGTGAAATTCCTGTGGGAGT	0.562000								Direct reversal of damage;Homologous recombination					5	97					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27709681	27709681	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27709681G>A	ENST00000261588.4	+	9	992	c.973G>A	c.(973-975)Gca>Aca	p.A325T	KIAA0556_ENST00000567894.1_3'UTR|CTD-2049O4.1_ENST00000564893.1_RNA	NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	325										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						ACCCCTGTCTGCAACCCGCAA	0.572000													58	207					0	0	1	0	0
SIK2	23235	broad.mit.edu	37	11	111594826	111594826	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:111594826A>G	ENST00000304987.3	+	15	2927	c.2754A>G	c.(2752-2754)caA>caG	p.Q918Q		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	918					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						TGGATCCACAACACAACGGGT	0.498000													19	55					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43162146	43162146	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:43162146T>C	ENST00000352483.2	-	9	1415	c.1351A>G	c.(1351-1353)Aca>Gca	p.T451A	RIPK4_ENST00000332512.3_Missense_Mutation_p.T403A|RIPK4_ENST00000544709.1_Missense_Mutation_p.T340A|RIPK4_ENST00000542057.1_Missense_Mutation_p.T340A			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	403						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGGACGTCTGTGGTGCCCAGA	0.617000													8	287					0	0	1	0	0
LIN28A	79727	broad.mit.edu	37	1	26752828	26752828	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:26752828T>C	ENST00000326279.6	+	4	623	c.509T>C	c.(508-510)aTg>aCg	p.M170T	LIN28A_ENST00000254231.4_Missense_Mutation_p.M170T	NM_024674.4	NP_078950.1	Q9H9Z2	LN28A_HUMAN	lin-28 homolog A (C. elegans)	170					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)	8						ATCAGCCATATGGTAGCCTCA	0.547000													14	123					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44803673	44803673	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44803673G>A	ENST00000372262.3	-	11	2359	c.1959C>T	c.(1957-1959)agC>agT	p.S653S	CDH22_ENST00000537909.1_Silent_p.S653S	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	653					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				AGCTCAGGTGGCTCTTGTGGT	0.622000													6	69					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3948457	3948457	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:3948457C>T	ENST00000313946.8	-	0	1232																											AGGGACAGCTCGGGGACCATG	0.627000													25	80					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342679	29342679	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:29342679C>T	ENST00000396806.3	-	1	389	c.386G>A	c.(385-387)cGc>cAc	p.R129H	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						GACAGTGTAGCGAAGAGGATT	0.493000													14	61					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147096415	147096415	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:147096415C>T	ENST00000234739.3	+	10	4676	c.3936C>T	c.(3934-3936)ggC>ggT	p.G1312G		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1312	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CCATGCCAGGCCACAACCCCA	0.577000			T	"""IGH@, IGL@"""	B-ALL								23	70					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20658921	20658921	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:20658921G>A	ENST00000428453.1	-	0	1945																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						ACAAAACATCGCATACGGCAC	0.388000													14	104					0	0	1	0	0
MAPK4	5596	broad.mit.edu	37	18	48252422	48252422	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:48252422A>G	ENST00000400384.2	+	5	1980	c.944A>G	c.(943-945)tAc>tGc	p.Y315C	MAPK4_ENST00000592595.1_Intron|MAPK4_ENST00000540640.1_Missense_Mutation_p.Y104C	NM_002747.3	NP_002738.2	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	315					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(3)|upper_aerodigestive_tract(1)	8		Colorectal(6;0.0297)		Colorectal(21;0.156)		ATGAGCCCATACTCGTGCCCT	0.577000													42	116					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58206860	58206860	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:58206860A>G	ENST00000302572.2	-	1	786	c.765T>C	c.(763-765)ttT>ttC	p.F255F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAAGTACATAAAGATTCCTG	0.458000													28	67					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176132	140176132	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140176132T>C	ENST00000526136.1	+	1	1583	c.1583T>C	c.(1582-1584)gTg>gCg	p.V528A	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.V528A|PCDHA2_ENST00000520672.2_Missense_Mutation_p.V528A	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGAGGAAGTGGAGCTGCTG	0.682000													65	157					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65138890	65138890	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:65138890A>G	ENST00000371073.2	+	18	2560	c.2560A>G	c.(2560-2562)Atc>Gtc	p.I854V	CACHD1_ENST00000290039.5_Missense_Mutation_p.I803V|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	854					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CCCGACTCTCATCGACCCCAA	0.493000													12	226					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102963965	102963965	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:102963965C>T	ENST00000359520.7	+	19	4216	c.3990C>T	c.(3988-3990)aaC>aaT	p.N1330N		NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1330							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						GCTGTCCAAACGGAGACCTCG	0.667000													6	22					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58125404	58125404	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:58125404C>T	ENST00000257897.3	-	9	1052	c.967G>A	c.(967-969)Gag>Aag	p.E323K	AGAP2_ENST00000547588.1_Missense_Mutation_p.E659K	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	659	Interaction with PLCG1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding	p.E659K(1)|p.E323K(1)		breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						CTTCGTTTCTCGGAGTCACTA	0.522000													24	79					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773130	140773130	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140773130A>G	ENST00000398604.2	+	1	750	c.750A>G	c.(748-750)aaA>aaG	p.K250K	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGAGTGAAAGTCCTTGAGA	0.542000													57	139					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79782066	79782066	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:79782066T>C	ENST00000372371.3	-	6	859	c.722A>G	c.(721-723)aAc>aGc	p.N241S		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	241					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GGCTTCTGGGTTCATCAGAAG	0.438000													21	45					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123601221	123601221	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:123601221T>C	ENST00000336139.4	-	3	738	c.376A>G	c.(376-378)Aaa>Gaa	p.K126E	ZNF202_ENST00000530393.1_Missense_Mutation_p.K126E|ZNF202_ENST00000529691.1_Missense_Mutation_p.K126E			O95125	ZN202_HUMAN	zinc finger protein 202	126	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CTGGGTTGTTTCTGCAAACCC	0.587000													14	188					0	0	1	0	0
CNDP2	55748	broad.mit.edu	37	18	72185802	72185802	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:72185802C>T	ENST00000324262.4	+	10	1453	c.1137C>T	c.(1135-1137)ggC>ggT	p.G379G	CNDP2_ENST00000579847.1_Silent_p.G379G|CNDP2_ENST00000324301.8_Silent_p.G295G	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	379						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		TGTACATGGGCCACGGTGGGA	0.502000													31	104					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35646772	35646772	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:35646772T>A	ENST00000440995.2	+	5	589	c.589T>A	c.(589-591)Tac>Aac	p.Y197N	SPEF2_ENST00000356031.3_Missense_Mutation_p.Y197N|SPEF2_ENST00000282469.6_Missense_Mutation_p.Y197N|SPEF2_ENST00000509059.1_Missense_Mutation_p.Y197N			Q9C093	SPEF2_HUMAN	sperm flagellar 2	197					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TATTCAGCAATACTTAAACAG	0.303000													5	118					0	0	1	0	0
CRYL1	51084	broad.mit.edu	37	13	21006355	21006355	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:21006355G>A	ENST00000382812.1	-	6	681	c.453C>T	c.(451-453)caC>caT	p.H151H	CRYL1_ENST00000480748.1_5'UTR|CRYL1_ENST00000298248.7_Silent_p.H173H			Q9Y2S2	CRYL1_HUMAN	crystallin, lambda 1	173					fatty acid metabolic process	cytosol	3-hydroxyacyl-CoA dehydrogenase activity|L-gulonate 3-dehydrogenase activity|NAD+ binding|protein homodimerization activity			NS(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(29;2.27e-23)|all_epithelial(30;1.69e-19)|all_lung(29;8.29e-18)|Lung SC(185;0.0262)|Ovarian(182;0.0827)|Hepatocellular(188;0.244)		all cancers(112;6.6e-05)|Epithelial(112;0.00178)|OV - Ovarian serous cystadenocarcinoma(117;0.0169)|Lung(94;0.0215)|GBM - Glioblastoma multiforme(144;0.0402)|LUSC - Lung squamous cell carcinoma(192;0.061)		TCATCAGGGCGTGGGTTCTGT	0.582000													30	69					0	0	1	0	0
NAMPT	10135	broad.mit.edu	37	7	105894879	105894879	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:105894879T>C	ENST00000222553.3	-	9	1468	c.1161A>G	c.(1159-1161)ctA>ctG	p.L387L		NM_005746.2	NP_005737.1	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	387					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						TCAACTTCTGTAGCAAACCTC	0.358000													31	76					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182072	140182072	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140182072G>A	ENST00000522353.2	+	1	1290	c.1290G>A	c.(1288-1290)ggG>ggA	p.G430G	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Silent_p.G430G|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGGGACGGGGGCTCGCCTT	0.627000													70	222					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126059484	126059484	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:126059484T>C	ENST00000318410.7	-	20	2818	c.2469A>G	c.(2467-2469)cgA>cgG	p.R823R	KIAA0196_ENST00000517845.1_Silent_p.R675R	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	823					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTCTGCAGAGTCGACCAATAA	0.463000													8	72					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43596084	43596084	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:43596084A>G	ENST00000355710.3	+	2	483	c.251A>G	c.(250-252)aAc>aGc	p.N84S	RET_ENST00000340058.5_Missense_Mutation_p.N84S	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	84					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CATGAGAACAACTGGATCTGC	0.637000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				8	25					0	0	1	0	0
ACSF3	197322	broad.mit.edu	37	16	89187260	89187260	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:89187260A>G	ENST00000317447.4	+	7	1555	c.1178A>G	c.(1177-1179)aAc>aGc	p.N393S	ACSF3_ENST00000406948.3_Missense_Mutation_p.N393S|ACSF3_ENST00000378345.4_Missense_Mutation_p.N128S	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	393					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		GTCTCAGAAAACCCACAGAGG	0.602000													33	329					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37146167	37146167	+	Nonsense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:37146167C>G	ENST00000262879.6	+	8	1354	c.1070C>G	c.(1069-1071)tCa>tGa	p.S357*	RALGAPB_ENST00000397042.3_Nonsense_Mutation_p.S357*|RALGAPB_ENST00000397038.1_Nonsense_Mutation_p.S135*|RALGAPB_ENST00000537204.1_Nonsense_Mutation_p.S357*|RALGAPB_ENST00000397040.1_Nonsense_Mutation_p.S357*			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	357					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AGACCCCGATCAGACAGTGCT	0.418000													26	93					0	0	1	0	0
KBTBD4	55709	broad.mit.edu	37	11	47595031	47595031	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47595031A>G	ENST00000533290.1	-	3	1797	c.1083T>C	c.(1081-1083)ggT>ggC	p.G361G	KBTBD4_ENST00000395288.2_Silent_p.G336G|NDUFS3_ENST00000533507.1_Intron|KBTBD4_ENST00000526005.1_Silent_p.G336G|KBTBD4_ENST00000430070.2_Silent_p.G352G			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	336										NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						GTGTCTTGCCACCCAGTGAAT	0.542000													19	56					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108788570	108788570	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:108788570A>T	ENST00000232603.5	-	9	806	c.724T>A	c.(724-726)Tct>Act	p.S242T	MORC1_ENST00000483760.1_Missense_Mutation_p.S242T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	242					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TACAGAACAGATGTGTAGGCT	0.378000													17	43					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275344	71275344	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:71275344C>T	ENST00000399575.2	+	3	473	c.299C>T	c.(298-300)cCg>cTg	p.P100L	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	100	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CGACTCTTTCCGGGTTATCCA	0.408000													58	165					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433507	73433507	+	Missense_Mutation	SNP	C	C	A	rs147152211		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:73433507C>A	ENST00000263666.4	-	10	2324	c.2210G>T	c.(2209-2211)aGa>aTa	p.R737I	PDZRN3_ENST00000462146.2_Missense_Mutation_p.R394I|PDZRN3_ENST00000535920.1_Missense_Mutation_p.R459I|PDZRN3_ENST00000479530.1_Missense_Mutation_p.R454I|PDZRN3_ENST00000466780.1_Missense_Mutation_p.R394I	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	737							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GAGCTCGTGTCTGCGCACGTC	0.617000													15	39					3.35478e-16	3.52021e-16	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276402	186276402	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:186276402C>T	ENST00000445192.2	+	7	1596	c.1551C>T	c.(1549-1551)acC>acT	p.T517T	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367483.4_Silent_p.T476T|PRG4_ENST00000367486.3_Silent_p.T474T|PRG4_ENST00000367485.4_Silent_p.T424T	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	517	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTTCACCCACCACTCCCAAGG	0.642000													5	176					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48869597	48869597	+	Splice_Site	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:48869597G>C	ENST00000394754.1	+	6	2529		c.e6+1		STON1-GTF2A1L_ENST00000405008.1_Splice_Site|STON1-GTF2A1L_ENST00000402114.2_Splice_Site|STON1-GTF2A1L_ENST00000394751.3_Intron|GTF2A1L_ENST00000468326.1_Splice_Site|GTF2A1L_ENST00000430487.2_Splice_Site|GTF2A1L_ENST00000403751.3_Splice_Site|LHCGR_ENST00000420913.3_Intron|STON1-GTF2A1L_ENST00000309827.2_Splice_Site	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN							endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGCAGAACTGGTATGTAGCTT	0.348000													5	20					0	0	1	0	0
SLC25A32	81034	broad.mit.edu	37	8	104419961	104419961	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:104419961A>G	ENST00000297578.4	-	2	372	c.206T>C	c.(205-207)tTg>tCg	p.L69S	SLC25A32_ENST00000543107.1_5'UTR	NM_030780.3	NP_110407.2	Q9H2D1	MFTC_HUMAN	solute carrier family 25 (mitochondrial folate carrier), member 32	69					folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	9			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	AATGGTAGTCAAGCAATGTAA	0.413000													34	169					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794875	30794875	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30794875G>A	ENST00000262525.4	-	3	981	c.774C>T	c.(772-774)ggC>ggT	p.G258G		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			AGGGCTTCTCGCCGGTGTGGG	0.622000													37	101					0	0	1	0	0
ZNF48	197407	broad.mit.edu	37	16	30410127	30410127	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30410127A>G	ENST00000320159.2	+	2	1932	c.1556A>G	c.(1555-1557)aAc>aGc	p.N519S		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	519	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						CGGCCACATAACCCACCTGGC	0.657000													56	143					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563856	140563856	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140563856G>A	ENST00000361016.2	+	1	2877	c.1722G>A	c.(1720-1722)gaG>gaA	p.E574E		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		574	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCACTGAGCTGGTGCCCC	0.697000													5	178					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76430135	76430135	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:76430135T>C	ENST00000389840.5	-	75	12306	c.12182A>G	c.(12181-12183)tAc>tGc	p.Y4061C	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.Y4062C					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGGTAGTTGTAGAGCACGTT	0.612000													51	168					0	0	1	0	0
PACSIN3	29763	broad.mit.edu	37	11	47201009	47201009	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47201009A>G	ENST00000539589.1	-	7	1074	c.732T>C	c.(730-732)gaT>gaC	p.D244D	PACSIN3_ENST00000298838.6_Silent_p.D244D	NM_001184975.1	NP_001171904.1	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in neurons 3	244					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)	11						TGAGCAGCATATCCTTGAAGA	0.567000											OREG0020952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	50					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17809131	17809131	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:17809131T>C	ENST00000378814.5	-	18	2030	c.2031A>G	c.(2029-2031)aaA>aaG	p.K677K	KIF13A_ENST00000259711.6_Silent_p.K677K|KIF13A_ENST00000378816.5_Silent_p.K677K|KIF13A_ENST00000378826.2_Silent_p.K677K|KIF13A_ENST00000378843.2_Silent_p.K677K	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	677					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GCTCTCGCAGTTTTGCCAGGC	0.458000													3	26					0	0	1	0	0
AKNAD1	254268	broad.mit.edu	37	1	109369904	109369904	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109369904T>C	ENST00000370001.3	-	11	2127	c.1859A>G	c.(1858-1860)aAg>aGg	p.K620R	AKNAD1_ENST00000357393.4_Missense_Mutation_p.K327R|AKNAD1_ENST00000369995.3_Missense_Mutation_p.K620R|AKNAD1_ENST00000369994.1_Missense_Mutation_p.K590R	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	620										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TCCGTGGCCCTTTTTCTCCAC	0.413000													5	231					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111731283	111731283	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:111731283A>G	ENST00000398006.2	-	5	947	c.39T>C	c.(37-39)ttT>ttC	p.F13F	ALG9_ENST00000531154.1_Silent_p.F13F|ALG9_ENST00000527228.1_5'UTR|ALG9_ENST00000524880.1_3'UTR	NM_001077690.1|NM_001077691.1|NM_001077692.1	NP_001071158.1|NP_001071159.1|NP_001071160.1	Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	184					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		ATGATGAGCAAAACATGCCAG	0.463000													15	36					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36952337	36952337	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:36952337C>T	ENST00000262865.4	+	8	923	c.834C>T	c.(832-834)ccC>ccT	p.P278P	BPI_ENST00000489102.1_3'UTR|CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	278					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				TGGAGTTTCCCGCTGCCCATG	0.537000													4	72					0	0	1	0	0
CCT4	10575	broad.mit.edu	37	2	62096656	62096656	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:62096656A>G	ENST00000394440.3	-	13	1820	c.1524T>C	c.(1522-1524)gtT>gtC	p.V508V	CCT4_ENST00000461540.2_5'UTR|AC107081.5_ENST00000425779.1_RNA|CCT4_ENST00000538252.1_Silent_p.V452V|CCT4_ENST00000544079.1_Silent_p.V478V|CCT4_ENST00000544185.1_Silent_p.V358V	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	508					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			GAGGCTGGACAACCAGTTCCT	0.438000													11	43					0	0	1	0	0
GNB1L	54584	broad.mit.edu	37	22	19776318	19776318	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:19776318A>G	ENST00000329517.6	-	8	1134	c.898T>C	c.(898-900)Tgc>Cgc	p.C300R	GNB1L_ENST00000460402.1_5'UTR|GNB1L_ENST00000403325.1_Missense_Mutation_p.C300R|GNB1L_ENST00000405009.1_Intron	NM_053004.2	NP_443730.1	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	300					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	12	Colorectal(54;0.0993)					AAGGCCACGCACTGGACAGCG	0.677000													4	61					0	0	1	0	0
MRPL23	6150	broad.mit.edu	37	11	1977618	1977618	+	Missense_Mutation	SNP	C	C	T	rs144125617	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1977618C>T	ENST00000397298.3	+	5	515	c.430C>T	c.(430-432)Cgg>Tgg	p.R144W	MRPL23_ENST00000381514.3_Intron|MRPL23_ENST00000381519.1_Missense_Mutation_p.R144W|MRPL23_ENST00000397297.3_Intron|MRPL23_ENST00000397294.3_Intron	NM_021134.3	NP_066957.3	Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	144					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|lung(1)|ovary(1)	4		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		CGACCCGCGGCGGGGCGGCGT	0.721000													18	46					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155253915	155253915	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155253915C>G	ENST00000357232.3	-	9	1947	c.1948G>C	c.(1948-1950)Gac>Cac	p.D650H	DCHS2_ENST00000339452.1_Missense_Mutation_p.D1149H	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	650	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GATTCATAGTCAAACTGTCGC	0.483000													29	100					0	0	1	0	0
HTR2A	3356	broad.mit.edu	37	13	47466612	47466612	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:47466612C>T	ENST00000378688.4	-	2	657	c.526G>A	c.(526-528)Gcc>Acc	p.A176T	HTR2A_ENST00000542664.1_Missense_Mutation_p.A176T|HTR2A_ENST00000543956.1_Missense_Mutation_p.A92T			P28223	5HT2A_HUMAN	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	176					ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity	p.A176T(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TTCTGGATGGCGACGTAGCGG	0.527000													113	317					0	0	1	0	0
NKPD1	284353	broad.mit.edu	37	19	45655588	45655588	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45655588T>C	ENST00000317951.4	-	4	2106	c.2107A>G	c.(2107-2109)Acc>Gcc	p.T703A	NKPD1_ENST00000429338.1_Intron|NKPD1_ENST00000589776.1_Missense_Mutation_p.T481A|NKPD1_ENST00000438936.2_Missense_Mutation_p.T481A	NM_198478.3	NP_940880.3			NTPase, KAP family P-loop domain containing 1											endometrium(1)|lung(4)|prostate(2)|urinary_tract(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		TTGGTCATGGTGTGCAGCTCG	0.716000													7	28					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29443576	29443576	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:29443576C>T	ENST00000389048.3	-	23	4547	c.3641G>A	c.(3640-3642)cGc>cAc	p.R1214H	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1214	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ACTCACCGGGCGAGGGCGGGT	0.617000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				11	44					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25073511	25073511	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:25073511A>G	ENST00000381989.3	-	5	510	c.405T>C	c.(403-405)ttT>ttC	p.F135F		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	135					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TCTGCATACCAAACCTGAAAT	0.269000													9	23					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168093656	168093656	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:168093656G>A	ENST00000519560.1	-	36	4794	c.4375C>T	c.(4375-4377)Cgc>Tgc	p.R1459C	CTC-558O2.2_ENST00000520041.1_RNA|SLIT3_ENST00000332966.8_Missense_Mutation_p.R1466C	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1459	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding	p.R1459S(2)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCTGGCGGCGGATCACCTCT	0.607000													22	71					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184072050	184072050	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:184072050G>A	ENST00000265593.4	-	15	1731	c.1560C>T	c.(1558-1560)atC>atT	p.I520I	CLCN2_ENST00000344937.7_Silent_p.I503I|CLCN2_ENST00000434054.2_Silent_p.I476I|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000423355.2_3'UTR|CLCN2_ENST00000457512.1_Silent_p.I520I	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	520						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCTCGAACACGATCACAGCCG	0.627000											OREG0015949	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	33					0	0	1	0	0
ZNF587B	100293516	broad.mit.edu	37	19	58367483	58367483	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58367483G>A	ENST00000316462.4	+	4	672	c.490G>A	c.(490-492)Gac>Aac	p.D164N	ZNF587_ENST00000423137.1_Silent_p.V14V|ZNF814_ENST00000597832.1_Intron|ZNF587_ENST00000419854.1_5'UTR|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597652.1_Intron|ZNF814_ENST00000596604.1_Intron|CTD-2583A14.10_ENST00000598031.1_Silent_p.V15V|ZNF587_ENST00000339656.5_Silent_p.V15V			B4DR41	B4DR41_HUMAN	zinc finger protein 587B	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding										AGGGCACTGTGACCTTTGAAG	0.537000													5	215					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682009	47682009	+	Missense_Mutation	SNP	G	G	A	rs138156132	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:47682009G>A	ENST00000283303.2	+	6	1286	c.1028G>A	c.(1027-1029)cGc>cAc	p.R343H	GPR115_ENST00000327753.3_Missense_Mutation_p.R343H|GPR115_ENST00000371220.1_Missense_Mutation_p.R400H	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	343					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						AATAAAACCCGCAATGCCAGA	0.458000													16	88					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36909285	36909285	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:36909285A>G	ENST00000451493.1	-	2	900	c.683T>C	c.(682-684)gTa>gCa	p.V228A	SPG20_ENST00000355182.4_Missense_Mutation_p.V228A|SPG20_ENST00000495510.1_5'UTR|SPG20_ENST00000438666.2_Missense_Mutation_p.V228A|SPG20_ENST00000494062.2_Missense_Mutation_p.V228A	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	228					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		AAAAATCTGTACTCCATTTGG	0.428000													29	95					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37574875	37574875	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:37574875T>C	ENST00000264741.5	+	14	1700	c.1444T>C	c.(1444-1446)Tgt>Cgt	p.C482R	ITGA9_ENST00000422441.1_Missense_Mutation_p.C482R	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	482					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AGCGCCTCAGTGTCACGACGG	0.552000													20	61					0	0	1	0	0
ENPP3	5169	broad.mit.edu	37	6	132068068	132068068	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:132068068A>G	ENST00000414305.1	+	26	2928	c.2600A>G	c.(2599-2601)tAt>tGt	p.Y867C	ENPP3_ENST00000358229.5_3'UTR|ENPP3_ENST00000357639.3_Missense_Mutation_p.Y867C			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	867	Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CTAAAGACATATTTACCAACA	0.328000													12	38					0	0	1	0	0
RIMKLB	57494	broad.mit.edu	37	12	8866471	8866471	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:8866471T>C	ENST00000357529.3	+	3	1271	c.9T>C	c.(7-9)agT>agC	p.S3S	RIMKLB_ENST00000538135.1_Silent_p.S3S|RIMKLB_ENST00000299673.5_3'UTR|RIMKLB_ENST00000535829.1_Silent_p.S3S	NM_020734.2	NP_065785.2	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family member B	3					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						AGATGTGTAGTTCTGTGGCTG	0.408000													16	73					0	0	1	0	0
NBPF18P	441908	broad.mit.edu	37	1	151993729	151993729	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:151993729G>A	ENST00000432386.1	+	0	2564					NR_103561.1																						GATGCCTCCCGCTCATTGAAT	0.552000													24	95					0	0	1	0	0
ZNF765	91661	broad.mit.edu	37	19	53905357	53905357	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53905357C>G	ENST00000396408.3	+	3	172	c.55C>G	c.(55-57)Cag>Gag	p.Q19E	ZNF765_ENST00000594030.1_Missense_Mutation_p.Q19E	NM_001040185.1	NP_001035275.1	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	19	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(3)	4				GBM - Glioblastoma multiforme(134;0.00379)		AGAATTCTCTCAGGAGGAGTG	0.448000													35	150					0	0	1	0	0
FLVCR1	28982	broad.mit.edu	37	1	213062505	213062505	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:213062505C>T	ENST00000366971.4	+	8	1629	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F	FLVCR1_ENST00000483790.1_3'UTR	NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	477					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		GAATTTTGTTCACATTGGCTC	0.303000													19	74					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127714648	127714648	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:127714648A>G	ENST00000354725.3	+	17	2068	c.1874A>G	c.(1873-1875)cAc>cGc	p.H625R		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	625	TNase-like 4.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						CTGGTGGAGCACGCGCTCTCC	0.602000													4	38					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39647368	39647368	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:39647368G>A	ENST00000262039.4	+	24	2626	c.2540G>A	c.(2539-2541)cGc>cAc	p.R847H	PIK3C3_ENST00000588156.1_Missense_Mutation_p.R71H|PIK3C3_ENST00000587328.1_Missense_Mutation_p.R25H|PIK3C3_ENST00000593098.1_Missense_Mutation_p.R332H|PIK3C3_ENST00000398870.3_Missense_Mutation_p.R784H	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	847	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						GATAAATTCCGCTTAGACCTG	0.413000										TSP Lung(28;0.18)			7	54					0	0	1	0	0
DNASE1L2	1775	broad.mit.edu	37	16	2287441	2287441	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2287441G>T	ENST00000564065.1	+	4	1383	c.382G>T	c.(382-384)Gag>Tag	p.E128*	DNASE1L2_ENST00000567494.1_Nonsense_Mutation_p.E128*|DNASE1L2_ENST00000382437.4_Nonsense_Mutation_p.E128*|DNASE1L2_ENST00000320700.5_Nonsense_Mutation_p.E128*			Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2	128					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding			endometrium(1)|prostate(1)|skin(2)	4						CTTCAGCCGCGAGCCCTTCGT	0.711000													4	14					3.59834e-05	3.66827e-05	1	1	0
TP53BP1	7158	broad.mit.edu	37	15	43748260	43748260	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43748260A>G	ENST00000263801.3	-	12	2783	c.2531T>C	c.(2530-2532)tTa>tCa	p.L844S	TP53BP1_ENST00000382044.4_Missense_Mutation_p.L849S|TP53BP1_ENST00000382039.3_Missense_Mutation_p.L849S|TP53BP1_ENST00000605155.1_5'UTR|TP53BP1_ENST00000450115.2_Missense_Mutation_p.L849S	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	844					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTCAAGTCTTAAAGGATCATC	0.423000								Other conserved DNA damage response genes					61	101					0	0	1	0	0
THRA	7067	broad.mit.edu	37	17	38249565	38249565	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:38249565A>G	ENST00000264637.4	+	10	1983	c.1403A>G	c.(1402-1404)gAc>gGc	p.D468G	THRA_ENST00000394121.4_Missense_Mutation_p.D468G|NR1D1_ENST00000246672.3_Intron|THRA_ENST00000584985.1_Missense_Mutation_p.D429G	NM_003250.5	NP_003241.2	P10827	THA_HUMAN	thyroid hormone receptor, alpha	468					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	AGTGAGGCGGACTCCCCGAGC	0.657000													13	45					0	0	1	0	0
ZFP91	80829	broad.mit.edu	37	11	58384240	58384240	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:58384240A>G	ENST00000316059.6	+	10	1325	c.1154A>G	c.(1153-1155)cAc>cGc	p.H385R	ZFP91-CNTF_ENST00000389919.4_Missense_Mutation_p.H385R	NM_001197051.1|NM_053023.4	NP_001183980.1|NP_444251.1	Q96JP5	ZFP91_HUMAN	ZFP91 zinc finger protein	385					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AAGAGTTCCCACAATCTGGCA	0.413000													15	69					0	0	1	0	0
FAM189A2	9413	broad.mit.edu	37	9	71986447	71986447	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:71986447T>C	ENST00000257515.8	+	3	465	c.45T>C	c.(43-45)tgT>tgC	p.C15C	FAM189A2_ENST00000303068.7_Intron|FAM189A2_ENST00000455972.1_Silent_p.C15C	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	15						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTGGTTTGTGTCCTCTTAA	0.448000													9	156					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33565764	33565764	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:33565764A>G	ENST00000321505.4	+	1	1944	c.1764A>G	c.(1762-1764)acA>acG	p.T588T	KIAA1549L_ENST00000265654.5_Silent_p.T588T|KIAA1549L_ENST00000389726.3_Silent_p.T588T					KIAA1549-like																		ATGCTTCCACACCATTCCAGA	0.468000													36	123					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187629423	187629423	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:187629423C>T	ENST00000441802.2	-	2	1768	c.1559G>A	c.(1558-1560)aGt>aAt	p.S520N		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	520	Cadherin 4.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTCTGACGTACTCACGGCACC	0.517000										HNSCC(5;0.00058)			5	113					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58831368	58831368	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:58831368A>C	ENST00000355431.3	+	20	2934	c.2561A>C	c.(2560-2562)aAg>aCg	p.K854T	ARID4A_ENST00000431317.2_Missense_Mutation_p.K854T|ARID4A_ENST00000348476.3_Missense_Mutation_p.K854T|ARID4A_ENST00000395168.3_Missense_Mutation_p.K854T	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	854					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AAAGAAAAGAAGTTGAAACGG	0.333000													14	38					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13708105	13708105	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:13708105A>G	ENST00000357447.2	-	18	1963	c.1595T>C	c.(1594-1596)aTc>aCc	p.I532T	FRMD4A_ENST00000378503.1_Missense_Mutation_p.I532T|FRMD4A_ENST00000358621.4_Missense_Mutation_p.I517T	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	532						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						ACCGTCTATGATCAGCGAAGC	0.592000													32	123					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64596825	64596825	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:64596825T>C	ENST00000357395.3	+	77	14498	c.3354T>C	c.(3352-3354)ccT>ccC	p.P1118P	SYNE2_ENST00000344113.4_Silent_p.P4733P|SYNE2_ENST00000394768.2_Silent_p.P1118P|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000554584.1_Silent_p.P4650P|SYNE2_ENST00000358025.3_Silent_p.P4733P|SYNE2_ENST00000555002.1_Silent_p.P1367P			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4733					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAGCAGCCCTTTCGTCACTG	0.473000													18	64					0	0	1	0	0
PHKG1	5260	broad.mit.edu	37	7	56148943	56148943	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:56148943C>T	ENST00000452681.2	-	11	1213	c.1064G>A	c.(1063-1065)cGc>cAc	p.R355H	PHKG1_ENST00000537360.1_Missense_Mutation_p.R269H|PHKG1_ENST00000297373.2_Missense_Mutation_p.R323H	NM_001258459.1	NP_001245388.1	Q16816	PHKG1_HUMAN	phosphorylase kinase, gamma 1 (muscle)	323	Calmodulin-binding (domain-C).				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			endometrium(1)|large_intestine(1)|lung(5)	7	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTTCACCCGGCGGTACTGGTA	0.667000													17	31					0	0	1	0	0
C1orf112	55732	broad.mit.edu	37	1	169796951	169796951	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:169796951C>T	ENST00000286031.6	+	12	1797	c.1097C>T	c.(1096-1098)aCa>aTa	p.T366I	C1orf112_ENST00000359326.4_Missense_Mutation_p.T366I|C1orf112_ENST00000413811.2_Intron|C1orf112_ENST00000498289.1_3'UTR	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	366										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTGTGGTGCACAGACAGCCAG	0.463000													107	383					0	0	1	0	0
CDCA4	55038	broad.mit.edu	37	14	105478187	105478187	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:105478187A>T	ENST00000336219.3	-	2	235	c.80T>A	c.(79-81)gTg>gAg	p.V27E	CDCA4_ENST00000392590.3_Missense_Mutation_p.V27E	NM_017955.3	NP_060425.2	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	27						nucleus				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		GTATGAGGACACTGTCTTCAA	0.572000													37	123					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	23847555	23847555	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:23847555T>C	ENST00000303531.7	+	1	211	c.59T>C	c.(58-60)tTc>tCc	p.F20S	PRKCB_ENST00000498058.1_Missense_Mutation_p.F20S|PRKCB_ENST00000321728.7_Missense_Mutation_p.F20S	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	20					apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	ACCGTGCGCTTCGCCCGCAAA	0.701000													16	82					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177694329	177694329	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:177694329T>C	ENST00000390654.3	-	8	858	c.501A>G	c.(499-501)gcA>gcG	p.A167A	COL23A1_ENST00000407622.1_Silent_p.A131A	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	167	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		AGTCTCCTGGTGCACCCTGGG	0.527000													8	27					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126260867	126260867	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:126260867G>T	ENST00000319340.2	+	3	522	c.472G>T	c.(472-474)Gcc>Tcc	p.A158S		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	158					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		CTTCAGCCCCGCCGAGATCAA	0.736000													8	14					0.000157383	0.00015972	1	1	0
GPR174	84636	broad.mit.edu	37	X	78426811	78426811	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:78426811T>C	ENST00000276077.1	+	1	343	c.307T>C	c.(307-309)Tat>Cat	p.Y103H		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	103						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						TGTCAACATGTATGCAAGCAT	0.443000										HNSCC(63;0.18)			32	35					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976427	38976427	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:38976427A>G	ENST00000355481.4	+	34	5263	c.5132A>G	c.(5131-5133)tAt>tGt	p.Y1711C	RYR1_ENST00000360985.3_Missense_Mutation_p.Y1711C|RYR1_ENST00000359596.3_Missense_Mutation_p.Y1711C	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1711	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAGGCTACTATGACCTCCTC	0.652000													5	137					0	0	1	0	0
MCCC2	64087	broad.mit.edu	37	5	70927998	70927998	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:70927998T>C	ENST00000340941.6	+	8	918	c.789T>C	c.(787-789)gcT>gcC	p.A263A	MCCC2_ENST00000509358.2_Silent_p.A263A|MCCC2_ENST00000510895.2_3'UTR|MCCC2_ENST00000323375.8_Silent_p.A225A	NM_022132.4	NP_071415.1	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-CoA carboxylase 2 (beta)	263	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			endometrium(2)|kidney(15)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	30		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	TTGGAGGTGCTGATCTTCATT	0.383000													27	85					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122735613	122735613	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:122735613A>G	ENST00000267199.4	-	5	629	c.517T>C	c.(517-519)Tac>Cac	p.Y173H	VPS33A_ENST00000542310.1_5'UTR|RP11-512M8.5_ENST00000535844.1_Intron	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	173					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		GCTGCGTGGTACAGGCTCGTC	0.597000													36	60					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65936555	65936555	+	Splice_Site	SNP	G	G	T	rs148259687		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:65936555G>T	ENST00000321892.4	+	21	6699	c.6637_splice	c.e21-1	p.G2213_splice	BPTF_ENST00000577770.1_3'UTR|BPTF_ENST00000424123.3_Splice_Site_p.G2074_splice|BPTF_ENST00000335221.5_Splice_Site_p.G2213_splice|BPTF_ENST00000306378.6_Splice_Site_p.G2087_splice			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2213					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GTTTGGGTAGGTGCTCCTCAG	0.448000													9	21					1.76689e-08	1.82224e-08	1	1	0
HSH2D	84941	broad.mit.edu	37	19	16259620	16259620	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16259620C>T	ENST00000593154.2	+	4	591	c.60C>T	c.(58-60)caC>caT	p.H20H	HSH2D_ENST00000588246.1_Silent_p.H20H|HSH2D_ENST00000397372.4_Intron|HSH2D_ENST00000253680.6_Silent_p.H20H	NM_032855.2	NP_116244.1	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	20						cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|large_intestine(2)	4						GGTTTGTGCACACCCAGATGG	0.637000													37	79					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81929426	81929426	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:81929426G>A	ENST00000359376.3	+	13	1301	c.1087G>A	c.(1087-1089)Ggg>Agg	p.G363R		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	363	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						CTGCTGGGACGGGCCCGATGG	0.597000													31	94					0	0	1	0	0
HIF1AN	55662	broad.mit.edu	37	10	102306312	102306312	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:102306312A>G	ENST00000299163.5	+	6	968	c.868A>G	c.(868-870)Acc>Gcc	p.T290A		NM_017902.2	NP_060372.2	Q9NWT6	HIF1N_HUMAN	hypoxia inducible factor 1, alpha subunit inhibitor	290	Interaction with HIF1A.|Interaction with VHL.|JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	10		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		TGGGGGGATTACCATCACTGT	0.428000													49	160					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94674816	94674816	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:94674816C>A	ENST00000260526.6	-	4	613	c.431G>T	c.(430-432)gGa>gTa	p.G144V	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.G144V	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	144					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.G144E(1)		NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTACATATTTCCAAAGGTAAA	0.353000													3	14					0.115264	0.1157	1	1	0
HNRNPC	3183	broad.mit.edu	37	14	21679385	21679385	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21679385A>G	ENST00000430246.2	-	8	3830	c.879T>C	c.(877-879)tcT>tcC	p.S293S	HNRNPC_ENST00000555914.1_Silent_p.S292S|HNRNPC_ENST00000320084.7_Silent_p.S306S|HNRNPC_ENST00000555883.1_Silent_p.S250S|HNRNPC_ENST00000555309.1_Silent_p.S305S|HNRNPC_ENST00000554969.1_Silent_p.S293S|HNRNPC_ENST00000336053.6_3'UTR|HNRNPC_ENST00000554455.1_Silent_p.S306S|HNRNPC_ENST00000553753.1_3'UTR|HNRNPC_ENST00000556628.1_Silent_p.S226S|HNRNPC_ENST00000449098.1_Silent_p.S293S|HNRNPC_ENST00000553300.1_Silent_p.S293S|HNRNPC_ENST00000420743.2_Silent_p.S306S|HNRNPC_ENST00000557201.1_Silent_p.S306S|HNRNPC_ENST00000556897.1_Silent_p.S293S|HNRNPC_ENST00000556513.1_3'UTR|HNRNPC_ENST00000556142.1_3'UTR			P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C (C1/C2)	306	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding			breast(1)|liver(1)|lung(6)|skin(1)	9	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		TATGTGCTTAAGAGTCATCCT	0.433000													21	146					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292165	33292165	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:33292165G>C	ENST00000280979.4	+	13	5316	c.5146G>C	c.(5146-5148)Gca>Cca	p.A1716P	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1716					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGAATCGAATGCATCGTTCAG	0.468000													6	171					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19401333	19401333	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:19401333A>G	ENST00000375267.2	-	107	15611	c.15608T>C	c.(15607-15609)gTc>gCc	p.V5203A	UBR4_ENST00000375254.3_Missense_Mutation_p.V5182A|UBR4_ENST00000543981.1_Missense_Mutation_p.V846A|RP5-1126H10.2_ENST00000606379.1_RNA|UBR4_ENST00000375225.3_Missense_Mutation_p.V257A|UBR4_ENST00000375217.2_Missense_Mutation_p.V5175A|UBR4_ENST00000375224.1_Missense_Mutation_p.V889A|UBR4_ENST00000375226.2_Missense_Mutation_p.V5158A|UBR4_ENST00000429347.2_Missense_Mutation_p.V705A			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5182					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGTCAGGGGACTGAGTTCAA	0.562000													6	28					0	0	1	0	0
CC2D2A	57545	broad.mit.edu	37	4	15569390	15569390	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:15569390G>A	ENST00000424120.1	+	26	3633	c.3379G>A	c.(3379-3381)Gaa>Aaa	p.E1127K	CC2D2A_ENST00000413206.1_Missense_Mutation_p.E1127K|CC2D2A_ENST00000503292.1_Missense_Mutation_p.E1127K|CC2D2A_ENST00000389652.5_Missense_Mutation_p.E1078K			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	1127	C2.				cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						CTGGAATGAAGAACTAGAACT	0.388000													5	26					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2275762	2275762	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:2275762A>G	ENST00000268989.3	+	15	1945	c.1768A>G	c.(1768-1770)Aag>Gag	p.K590E	SGSM2_ENST00000426855.2_Missense_Mutation_p.K545E|SGSM2_ENST00000574563.1_Missense_Mutation_p.K545E	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	545	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CGTGTGGAGCAAGTATCAGAA	0.657000													13	28					0	0	1	0	0
CLDN25	644672	broad.mit.edu	37	11	113650823	113650823	+	Silent	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:113650823T>A	ENST00000453129.2	+	1	355	c.306T>A	c.(304-306)tcT>tcA	p.S102S		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	102						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						GCTTTGGGTCTGAATGCTTCC	0.572000													8	382					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3612066	3612066	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:3612066T>C	ENST00000429344.2	-	10	2184	c.2132A>G	c.(2131-2133)cAc>cGc	p.H711R	CACTIN-AS1_ENST00000592274.1_RNA|CACTIN_ENST00000221899.3_Missense_Mutation_p.H643R|CACTIN_ENST00000248420.5_Missense_Mutation_p.H711R	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		CGGCCCCGCGTGGAAGCGCAG	0.612000													5	249					0	0	1	0	0
BAG5	9529	broad.mit.edu	37	14	104027343	104027343	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:104027343T>C	ENST00000445922.2	-	2	405	c.159A>G	c.(157-159)atA>atG	p.I53M	BAG5_ENST00000299204.4_Missense_Mutation_p.I53M|RP11-894P9.2_ENST00000556332.1_RNA|BAG5_ENST00000337322.4_Missense_Mutation_p.I94M	NM_004873.3	NP_004864.1	Q9UL15	BAG5_HUMAN	BCL2-associated athanogene 5	53	BAG 1.				apoptosis|negative regulation of protein refolding|negative regulation of ubiquitin-protein ligase activity|neuron death|protein folding|regulation of inclusion body assembly	inclusion body|perinuclear region of cytoplasm	chaperone binding|ubiquitin protein ligase binding			endometrium(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	24		Melanoma(154;0.155)	Epithelial(46;0.144)			CTACAGAGTCTATTTCAAAAA	0.413000													30	91					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96326712	96326712	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:96326712A>T	ENST00000277165.6	+	18	3441	c.3247A>T	c.(3247-3249)Aat>Tat	p.N1083Y	FAM120A_ENST00000333936.5_Missense_Mutation_p.N1111Y|FAM120A_ENST00000340893.4_Missense_Mutation_p.N1037Y	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	1083	RNA binding.					cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGCCTTGAATAATGACTCTAA	0.527000													34	114					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39579038	39579038	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39579038G>T	ENST00000225550.3	-	3	723	c.724C>A	c.(724-726)Cac>Aac	p.H242N	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	242	Coil 1B.|Rod.					intermediate filament	structural molecule activity	p.H242D(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				ACCTGCTCGTGGTTGCTCTTG	0.687000													6	47					3.59834e-05	3.66827e-05	1	1	0
TMEM136	219902	broad.mit.edu	37	11	120201091	120201091	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:120201091C>A	ENST00000375095.2	+	3	846	c.605C>A	c.(604-606)gCt>gAt	p.A202D	TMEM136_ENST00000531346.1_3'UTR|TMEM136_ENST00000529187.1_Intron|TMEM136_ENST00000314475.2_Missense_Mutation_p.A224D	NM_001198671.1|NM_001198672.1|NM_001198673.1|NM_001198674.1|NM_001198675.1	NP_001185600.1|NP_001185601.1|NP_001185602.1|NP_001185603.1|NP_001185604.1	Q6ZRR5	TM136_HUMAN	transmembrane protein 136	202	TLC.					integral to membrane				endometrium(1)|lung(2)|ovary(1)	4		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Hepatocellular(160;0.206)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.07e-06)		GCGATGTATGCTGTGTCTTGG	0.527000													4	57					0.00909568	0.00915862	1	1	0
PRDM5	11107	broad.mit.edu	37	4	121706189	121706189	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:121706189G>T	ENST00000264808.3	-	11	1486	c.1246C>A	c.(1246-1248)Cca>Aca	p.P416T	PRDM5_ENST00000515109.1_Missense_Mutation_p.P385T|PRDM5_ENST00000428209.2_Missense_Mutation_p.P385T	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	416					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAAGAAAATGGGGTCCGGAAC	0.403000													4	80					0.00024832	0.000251724	1	1	0
KIAA1429	25962	broad.mit.edu	37	8	95500996	95500996	+	Silent	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:95500996T>G	ENST00000297591.5	-	24	5452	c.5377A>C	c.(5377-5379)Aga>Cga	p.R1793R	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1793					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AACTTTCCTCTTGAGCCTCCA	0.488000													67	290					0	0	1	0	0
TTI2	80185	broad.mit.edu	37	8	33361334	33361334	+	Silent	SNP	G	G	A	rs140275385		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:33361334G>A	ENST00000431156.2	-	5	1665	c.1047C>T	c.(1045-1047)caC>caT	p.H349H	TTI2_ENST00000520636.1_Silent_p.H318H|TTI2_ENST00000360742.5_Silent_p.H349H|TTI2_ENST00000519356.1_5'UTR	NM_001102401.2	NP_001095871.1	Q6NXR4	CH041_HUMAN	TELO2 interacting protein 2	349							binding										CTGGCTCCATGTGGGTCAGGA	0.522000													16	37					0	0	1	0	0
FAM3C	10447	broad.mit.edu	37	7	120991304	120991304	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:120991304G>A	ENST00000359943.3	-	9	700	c.487C>T	c.(487-489)Cgg>Tgg	p.R163W		NM_001040020.1|NM_014888.2	NP_001035109.1|NP_055703.1	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	163					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity			kidney(1)|lung(8)	9	all_neural(327;0.117)					GCAATGAGCCGCCGTGCCTCA	0.423000													10	32					0	0	1	0	0
PEX6	5190	broad.mit.edu	37	6	42933788	42933788	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:42933788G>A	ENST00000304611.8	-	12	2425	c.2356C>T	c.(2356-2358)Cgg>Tgg	p.R786W	PEX6_ENST00000244546.4_Intron	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	786					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			TCACCTTCCCGCACATTCTCC	0.577000													45	179					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20884321	20884321	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:20884321C>A	ENST00000382152.2	-	2	240	c.73G>T	c.(73-75)Gct>Tct	p.A25S	KCNIP4_ENST00000359001.5_Intron|KCNIP4_ENST00000509207.1_Intron|KCNIP4_ENST00000382149.4_Intron|KCNIP4_ENST00000382148.3_Intron|KCNIP4_ENST00000382150.4_Intron|KCNIP4_ENST00000447367.2_Intron	NM_025221.5	NP_079497.2	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	25	KIS (By similarity).					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				CTGTTCTGAGCGTACAGGAAA	0.498000													12	32					1.41608e-15	1.48453e-15	1	1	0
RBPMS	11030	broad.mit.edu	37	8	30402247	30402247	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:30402247T>A	ENST00000520191.1	+	6	752	c.322T>A	c.(322-324)Tcc>Acc	p.S108T	RBPMS_ENST00000320203.4_Intron|RBPMS_ENST00000339877.4_Intron|RBPMS_ENST00000287771.5_Intron|RBPMS_ENST00000519647.1_Intron|RBPMS_ENST00000538486.1_Intron|RBPMS_ENST00000517860.1_Missense_Mutation_p.S212T|RBPMS_ENST00000520161.1_Intron|RBPMS_ENST00000397323.4_Intron			Q93062	RBPMS_HUMAN	RNA binding protein with multiple splicing	0					positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		AGCTAACAGATCCACCCTCAA	0.488000													18	56					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580935	140580935	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140580935C>T	ENST00000354757.3	+	1	1588	c.1588C>T	c.(1588-1590)Cgc>Tgc	p.R530C	PCDHB11_ENST00000536699.1_Missense_Mutation_p.R165C	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		530	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCGACTTCCGCGTGGGCGC	0.672000													66	183					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231337181	231337181	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:231337181T>C	ENST00000444294.3	+	5	2310	c.1452T>C	c.(1450-1452)tcT>tcC	p.S484S	TRIM67_ENST00000366652.2_Silent_p.S484S|TRIM67_ENST00000366653.5_Silent_p.S484S|TRIM67_ENST00000449018.3_Silent_p.S422S	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	484	COS.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CGAAAGTGTCTGCGGAGTTTG	0.562000													9	26					0	0	1	0	0
CD3EAP	10849	broad.mit.edu	37	19	45912313	45912313	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45912313A>G	ENST00000309424.3	+	3	1575	c.1087A>G	c.(1087-1089)Acc>Gcc	p.T363A	ERCC1_ENST00000423698.2_3'UTR|ERCC1_ENST00000300853.3_3'UTR|CD3EAP_ENST00000589804.1_Missense_Mutation_p.T365A	NM_012099.1	NP_036231.1	O15446	RPA34_HUMAN	CD3e molecule, epsilon associated protein	363					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		CCCAGGGGGGACCATGGCGCC	0.577000													39	87					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21521694	21521694	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21521694G>C	ENST00000222584.3	+	5	2278	c.2060G>C	c.(2059-2061)aGa>aCa	p.R687T		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	687					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						TGTGGCAAAAGATTCACACGG	0.378000													6	152					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135405143	135405143	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:135405143G>T	ENST00000394143.1	+	5	568	c.277G>T	c.(277-279)Gca>Tca	p.A93S	GPR112_ENST00000394141.1_Intron|GPR112_ENST00000412101.1_Intron|GPR112_ENST00000370652.1_Missense_Mutation_p.A93S|GPR112_ENST00000287534.4_Missense_Mutation_p.A30S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	93					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCTTGGACTTGCAGGAGACCA	0.428000													77	72					8.70839e-23	9.20852e-23	1	1	0
ALX4	60529	broad.mit.edu	37	11	44296905	44296905	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:44296905C>T	ENST00000329255.3	-	2	873	c.770G>A	c.(769-771)cGc>cAc	p.R257H		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	257			R -> T (in dbSNP:rs3824915).		hair follicle development					central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						GACCTGCACGCGGGCCTCAGT	0.622000													24	71					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35806427	35806427	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35806427G>A	ENST00000342694.2	+	16	2666	c.2411G>A	c.(2410-2412)cGc>cAc	p.R804H		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	804					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CTCCTGCTGCGCATGGAACAG	0.517000													23	63					0	0	1	0	0
CCDC78	124093	broad.mit.edu	37	16	775077	775077	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:775077C>T	ENST00000293889.6	-	6	666		c.e6+1			NM_001031737.2	NP_001026907.2	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78											central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(2)|skin(3)	9		Hepatocellular(780;0.0218)				TGGCCACTCACACACGCGTCA	0.667000													31	111					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248403002	248403002	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248403002A>G	ENST00000306687.1	+	1	772	c.772A>G	c.(772-774)Atg>Gtg	p.M258V		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGCTATGTTCATGTACATGAG	0.522000													20	73					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346241	29346241	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:29346241C>T	ENST00000558402.1	+	5	753	c.154C>T	c.(154-156)Cgg>Tgg	p.R52W	APBA2_ENST00000558330.1_Missense_Mutation_p.R52W|APBA2_ENST00000411764.1_Missense_Mutation_p.R52W|APBA2_ENST00000561069.1_Missense_Mutation_p.R52W|APBA2_ENST00000558259.1_Missense_Mutation_p.R52W			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	52					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGCTGCCCTGCGGCCAGAGAG	0.657000													5	106					0	0	1	0	0
S100B	6285	broad.mit.edu	37	21	48019297	48019297	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:48019297G>C	ENST00000291700.4	-	3	454	c.258C>G	c.(256-258)caC>caG	p.H86Q	S100B_ENST00000367071.4_3'UTR|S100B_ENST00000397648.1_Missense_Mutation_p.H86Q	NM_006272.2	NP_006263.1	P04271	S100B_HUMAN	S100 calcium binding protein B	86					axonogenesis|cell proliferation|central nervous system development|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular region|nucleus|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|RAGE receptor binding|S100 beta binding|tau protein binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5	Breast(49;0.247)	Lung NSC(3;0.245)		OV - Ovarian serous cystadenocarcinoma(3;1.84e-06)|Epithelial(3;4.45e-06)|all cancers(3;2.07e-05)|Colorectal(79;0.241)		CAAAGAACTCGTGGCAGGCAG	0.473000													4	125					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138667192	138667192	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:138667192C>T	ENST00000298480.5	+	20	2354	c.2280C>T	c.(2278-2280)atC>atT	p.I760I	KCNT1_ENST00000488444.2_Silent_p.I741I|KCNT1_ENST00000263604.3_Silent_p.I741I|KCNT1_ENST00000486577.2_Silent_p.I719I|KCNT1_ENST00000371757.2_Silent_p.I760I|KCNT1_ENST00000487664.1_Silent_p.I715I|KCNT1_ENST00000490355.2_Silent_p.I739I|KCNT1_ENST00000491806.2_Silent_p.I727I			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	760						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CGCCCTACATCGGCAGCTCCC	0.662000													28	72					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46328280	46328280	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:46328280A>G	ENST00000369367.3	-	7	705	c.472T>C	c.(472-474)Tta>Cta	p.L158L	SCAF11_ENST00000549162.1_5'UTR|SCAF11_ENST00000419565.2_Silent_p.L158L	NM_004719.2	NP_004710.2	Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	158					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TCACTGTATAAAGAGTTTCCT	0.333000													16	56					0	0	1	0	0
TMEM42	131616	broad.mit.edu	37	3	44903590	44903590	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:44903590G>A	ENST00000302392.4	+	1	230	c.174G>A	c.(172-174)aaG>aaA	p.K58K		NM_144638.1	NP_653239.1	Q69YG0	TMM42_HUMAN	transmembrane protein 42	58						integral to membrane		p.K58K(1)		central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00839)|KIRC - Kidney renal clear cell carcinoma(197;0.0461)|Kidney(197;0.0576)		CCTCCGCCAAGCTGGCCTTCG	0.776000													3	8					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131476394	131476394	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131476394C>T	ENST00000291906.4	+	10	1699	c.1306C>T	c.(1306-1308)Cgc>Tgc	p.R436C		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	436					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						CTTCTCTAAACGCAGAGGTGT	0.632000													32	135					0	0	1	0	0
SEPT6	23157	broad.mit.edu	37	X	118771104	118771104	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:118771104A>G	ENST00000394610.1	-	7	1106	c.842T>C	c.(841-843)gTc>gCc	p.V281A	SEPT6_ENST00000394617.2_Missense_Mutation_p.V311A|SEPT6_ENST00000360156.7_Missense_Mutation_p.V281A|SEPT6_ENST00000354228.4_Missense_Mutation_p.V281A|SEPT6_ENST00000354416.3_Missense_Mutation_p.V281A|SEPT6_ENST00000489216.1_Missense_Mutation_p.V281A|SEPT6_ENST00000343984.5_Missense_Mutation_p.V281A|SEPT6_ENST00000394616.4_Missense_Mutation_p.V223A	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	281					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						CTCCATGTTGACCCGAATCAG	0.547000			T	MLL	AML								28	45					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46135786	46135786	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:46135786T>C	ENST00000371383.2	-	3	474	c.214A>G	c.(214-216)Acc>Gcc	p.T72A	ENPP5_ENST00000230565.3_Missense_Mutation_p.T72A			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	72						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						TTAGGGTAGGTTTTTGTAATA	0.348000													11	39					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96291216	96291216	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:96291216A>G	ENST00000225235.4	+	12	2368	c.2259_splice	c.e12+1	p.Q753_splice	TBC1D12_ENST00000485048.1_3'UTR	NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	753						intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				AAATGGACTCAGGTAGAGTGA	0.323000													31	102					0	0	1	0	0
KRT23	25984	broad.mit.edu	37	17	39084610	39084610	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39084610A>G	ENST00000209718.3	-	6	1225	c.801T>C	c.(799-801)tcT>tcC	p.S267S	KRT23_ENST00000436344.3_Silent_p.S130S|AC004231.2_ENST00000418393.1_RNA	NM_015515.3	NP_056330.3	Q9C075	K1C23_HUMAN	keratin 23 (histone deacetylase inducible)	267	Coil 2.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				ACATGGCTGCAGACTGTGGGA	0.527000													38	120					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408303	105408303	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:105408303G>A	ENST00000333244.5	-	7	13604	c.13485C>T	c.(13483-13485)gcC>gcT	p.A4495A	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4495						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCTCATGTCGGCCTCCATCT	0.587000													61	218					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606125	84606125	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:84606125T>C	ENST00000344803.2	+	4	787	c.740T>C	c.(739-741)cTt>cCt	p.L247P		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CCCTTTCCCCTTCTCCCACCA	0.542000													89	298					0	0	1	0	0
GGT7	2686	broad.mit.edu	37	20	33451197	33451197	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:33451197C>T	ENST00000336431.5	-	2	368	c.324G>A	c.(322-324)acG>acA	p.T108T		NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	108					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						TGACGATGACCGTGAGCCCAT	0.672000													13	36					0	0	1	0	0
BRMS1	25855	broad.mit.edu	37	11	66107675	66107675	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66107675T>A	ENST00000359957.3	-	7	705	c.545A>T	c.(544-546)gAt>gTt	p.D182V	BRMS1_ENST00000425825.2_Missense_Mutation_p.D182V	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	182					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						CAGTTTGTCATCCCACCATTC	0.597000													22	50					0	0	1	0	0
CCNE2	9134	broad.mit.edu	37	8	95893861	95893861	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:95893861T>C	ENST00000520509.1	-	12	1466	c.1214A>G	c.(1213-1215)tAa>tGa	p.*405*	CCNE2_ENST00000396133.3_3'UTR|INTS8_ENST00000523731.1_3'UTR|CCNE2_ENST00000308108.4_Silent_p.*405*			O96020	CCNE2_HUMAN	cyclin E2	0					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					TTATCTTCTTTAGTGTTTTCC	0.403000													26	146					0	0	1	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768625	31768625	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:31768625G>T	ENST00000355459.2	+	1	234	c.221G>T	c.(220-222)aGc>aTc	p.S74I		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	74	5 X 10 AA approximate repeats.					intermediate filament				endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTGGAGTCCAGCCCCTGCCAG	0.607000													17	92					5.01169e-05	5.10218e-05	1	1	0
DOCK5	80005	broad.mit.edu	37	8	25198426	25198426	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25198426T>C	ENST00000276440.7	+	23	2405	c.2361T>C	c.(2359-2361)ttT>ttC	p.F787F		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	787						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GAGATGAGTTTAATAATTCAA	0.383000													12	36					0	0	1	0	0
SLF2	55719	broad.mit.edu	37	10	102672977	102672977	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:102672977C>T	ENST00000238961.3	+	1	258	c.110C>T	c.(109-111)gCg>gTg	p.A37V	FAM178A_ENST00000370269.3_Missense_Mutation_p.A37V|FAM178A_ENST00000370271.3_Missense_Mutation_p.A37V	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	37																	CATGCTGCAGCGGGAAAGAGA	0.687000													5	21					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7702465	7702465	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7702465T>C	ENST00000572933.1	+	56	10064	c.8604T>C	c.(8602-8604)ccT>ccC	p.P2868P	DNAH2_ENST00000389173.2_Silent_p.P2868P			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2868	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGCAGGTGCCTGAGTCATCGG	0.602000													18	65					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85617976	85617976	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:85617976C>T	ENST00000322366.6	-	56	8953	c.8545_splice	c.e56-1	p.G2849_splice	WDFY3_ENST00000295888.4_Splice_Site_p.G2866_splice			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2866	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGTTTACAGCCTATGCAATT	0.378000													10	42					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49132517	49132517	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49132517A>G	ENST00000443164.1	+	5	2343	c.1638A>G	c.(1636-1638)tcA>tcG	p.S546S	SPHK2_ENST00000245222.4_Silent_p.S484S|SPHK2_ENST00000598088.1_Silent_p.S484S|SPHK2_ENST00000600537.1_Silent_p.S425S|SPHK2_ENST00000340932.3_Silent_p.S446S|SPHK2_ENST00000599029.1_Silent_p.S448S|SPHK2_ENST00000599748.1_Silent_p.S448S			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	484					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CTCTACACTCACCCGTCTCCG	0.697000													49	167					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	830419	830419	+	Missense_Mutation	SNP	G	G	T	rs113763422		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:830419G>T	ENST00000293892.3	-	3	581	c.582C>A	c.(580-582)caC>caA	p.H194Q	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						GCACGTGTAAGTGACAGTGTG	0.592000													6	159					3.59834e-05	3.66827e-05	1	1	0
PBX4	80714	broad.mit.edu	37	19	19681579	19681579	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19681579T>C	ENST00000251203.8	-	3	543	c.257A>G	c.(256-258)aAc>aGc	p.N86S		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	86							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						CAGCAGCATGTTATCCAGCCT	0.577000													4	94					0	0	1	0	0
LMNB2	84823	broad.mit.edu	37	19	2435009	2435009	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2435009T>C	ENST00000325327.3	-	5	907	c.845A>G	c.(844-846)tAc>tGc	p.Y282C	LMNB2_ENST00000582871.1_Missense_Mutation_p.Y262C			Q03252	LMNB2_HUMAN	lamin B2	262	Coil 2.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTGGCCTGGTAGGTCTGCTC	0.716000													18	51					0	0	1	0	0
XKR3	150165	broad.mit.edu	37	22	17265161	17265161	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:17265161A>G	ENST00000331428.5	-	4	830	c.728T>C	c.(727-729)tTt>tCt	p.F243S		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	243						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AACCTCCAAAAAACGCCACAT	0.423000													9	50					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52794339	52794339	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52794339A>T	ENST00000257974.2	-	4	826	c.749T>A	c.(748-750)aTc>aAc	p.I250N	RP3-416H24.4_ENST00000547174.1_RNA	NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	250	Coil 1B.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		CAGGAAGTCGATCTCCTGCAC	0.597000													31	98					0	0	1	0	0
RPP25L	138716	broad.mit.edu	37	9	34611111	34611111	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:34611111G>A	ENST00000297613.4	-	2	463	c.183C>T	c.(181-183)ggC>ggT	p.G61G	RPP25L_ENST00000378959.4_Silent_p.G61G	NM_148179.2	NP_680545.1	Q8N5L8	CI023_HUMAN	ribonuclease P/MRP 25kDa subunit-like	61							nucleic acid binding										CTGCAGCCCTGCCAGAACCTG	0.607000													4	102					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28391388	28391388	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:28391388C>T	ENST00000261609.7	-	71	11111	c.11003G>A	c.(11002-11004)cGg>cAg	p.R3668Q		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3668					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTTACCTGACCGCACGGAGAC	0.557000													19	65					0	0	1	0	0
MTRF1L	54516	broad.mit.edu	37	6	153323624	153323624	+	Missense_Mutation	SNP	G	G	A	rs150895723		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:153323624G>A	ENST00000367233.5	-	1	196	c.197C>T	c.(196-198)gCg>gTg	p.A66V	MTRF1L_ENST00000464135.1_5'UTR|MTRF1L_ENST00000367230.1_Missense_Mutation_p.A66V|MTRF1L_ENST00000367231.5_Missense_Mutation_p.A66V	NM_019041.5	NP_061914.3	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor 1-like	66						mitochondrion	translation release factor activity, codon specific			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	10		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)		TTTGATCACCGCCAGCAACTC	0.657000													12	30					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131593276	131593276	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:131593276G>A	ENST00000261654.5	+	18	2454	c.1895G>A	c.(1894-1896)tGc>tAc	p.C632Y	GPR133_ENST00000376682.4_Missense_Mutation_p.C318Y|GPR133_ENST00000535015.1_Missense_Mutation_p.C664Y|GPR133_ENST00000543617.1_Missense_Mutation_p.C151Y	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	632					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TAGACCCCCTGCCAAGTGATG	0.572000													148	266					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151770123	151770123	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:151770123G>C	ENST00000535741.1	-	26	4659	c.4186C>G	c.(4186-4188)Caa>Gaa	p.Q1396E	LRBA_ENST00000357115.3_Missense_Mutation_p.Q1396E|LRBA_ENST00000510413.1_Missense_Mutation_p.Q1396E|LRBA_ENST00000507224.1_Missense_Mutation_p.Q1396E			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1396						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GAAAGGCCTTGAGTAGGTTCA	0.313000													42	111					0	0	1	0	0
TBC1D31	93594	broad.mit.edu	37	8	124156981	124156981	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:124156981T>C	ENST00000287380.1	+	20	2950	c.2860T>C	c.(2860-2862)Ttc>Ctc	p.F954L	TBC1D31_ENST00000309336.3_Missense_Mutation_p.F889L|TBC1D31_ENST00000521676.1_Missense_Mutation_p.F831L|TBC1D31_ENST00000378080.2_3'UTR|TBC1D31_ENST00000518805.1_Missense_Mutation_p.F508L|TBC1D31_ENST00000327098.5_Missense_Mutation_p.F858L|TBC1D31_ENST00000522420.1_Missense_Mutation_p.F849L	NM_145647.3	NP_663622.2			TBC1 domain family, member 31																		AGGAAAAGAGTTCCGTTTGAG	0.353000													9	48					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37742095	37742095	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:37742095A>G	ENST00000400485.1	+	15	2505	c.2429A>G	c.(2428-2430)gAt>gGt	p.D810G	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	810					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						AGTGAAATGGATGAGATGGCT	0.393000													63	139					0	0	1	0	0
FAM63B	54629	broad.mit.edu	37	15	59102491	59102491	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:59102491A>T	ENST00000559228.1	+	4	1108	c.1026A>T	c.(1024-1026)agA>agT	p.R342S	FAM63B_ENST00000450403.2_Missense_Mutation_p.R342S			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	342										central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						TAAATGTAAGATTCACTGGTG	0.378000													26	77					0	0	1	0	0
AP2B1	163	broad.mit.edu	37	17	33954513	33954513	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:33954513A>G	ENST00000262325.7	+	8	1601	c.1048A>G	c.(1048-1050)Aac>Gac	p.N350D	AP2B1_ENST00000592545.1_Missense_Mutation_p.N312D|AP2B1_ENST00000538556.1_Missense_Mutation_p.N293D|AP2B1_ENST00000537622.2_Missense_Mutation_p.N350D|AP2B1_ENST00000312678.8_Missense_Mutation_p.N350D|AP2B1_ENST00000545922.2_3'UTR|AP2B1_ENST00000589344.1_Missense_Mutation_p.N350D	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	350					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ATCTCAAGCCAACATTGCTCA	0.398000													14	41					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99023101	99023101	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99023101T>C	ENST00000292478.4	-	6	1304	c.1054A>G	c.(1054-1056)Act>Gct	p.T352A	ATP5J2-PTCD1_ENST00000413834.1_Missense_Mutation_p.T401A|PTCD1_ENST00000555673.1_Missense_Mutation_p.T401A	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TGAAGCACAGTCGCCTCCTCC	0.657000													14	53					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759250	121759250	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:121759250A>G	ENST00000261367.7	+	6	2387	c.959A>G	c.(958-960)aAg>aGg	p.K320R	SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000503116.2_Missense_Mutation_p.K320R|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000261368.8_Missense_Mutation_p.K273R|SNCAIP_ENST00000379536.2_Missense_Mutation_p.K273R|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.K320R			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	273					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AAAGTTGAGAAGACAACACCA	0.493000													17	46					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111631164	111631164	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:111631164C>G	ENST00000435970.1	-	32	9516	c.8700G>C	c.(8698-8700)ctG>ctC	p.L2900L	REV3L_ENST00000462119.1_5'UTR|RP5-1112D6.8_ENST00000607434.1_RNA|REV3L_ENST00000368805.1_Silent_p.L2978L|REV3L_ENST00000358835.3_Silent_p.L2978L|REV3L_ENST00000368802.3_Silent_p.L2978L			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2978					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CATTCAGTCTCAGAGTTGGGT	0.473000								DNA polymerases (catalytic subunits)					28	84					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21555623	21555623	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:21555623C>T	ENST00000382592.4	-	6	3052	c.2647G>A	c.(2647-2649)Gag>Aag	p.E883K	LATS2_ENST00000542899.1_Missense_Mutation_p.E883K	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	883	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		AGGAGCACCTCGGGTGCGATG	0.622000													12	60					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61502441	61502441	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:61502441G>A	ENST00000257215.5	+	10	1211	c.1095G>A	c.(1093-1095)gcG>gcA	p.A365A		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	365					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		ACATGACTGCGGTGGACATCG	0.637000													93	355					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38523186	38523186	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:38523186T>C	ENST00000399017.2	+	25	5023		c.e25+2		TTC3_ENST00000354749.2_Splice_Site|TTC3_ENST00000355666.1_Splice_Site|TTC3_ENST00000540756.1_Splice_Site|TTC3_ENST00000479930.1_Splice_Site	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3						protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				ATGTTCTAGGTAAGATTTTTA	0.289000													4	48					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132202402	132202402	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:132202402T>C	ENST00000260818.6	+	28	3411	c.3163T>C	c.(3163-3165)Tgt>Cgt	p.C1055R		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1055							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						GATCACAATGTGTGGATATTT	0.398000													32	78					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136594927	136594927	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:136594927T>C	ENST00000371872.4	-	6	1132	c.875A>G	c.(874-876)cAc>cGc	p.H292R	SARDH_ENST00000298628.5_Missense_Mutation_p.H292R|SARDH_ENST00000371867.1_Missense_Mutation_p.H203R|SARDH_ENST00000422262.2_Missense_Mutation_p.H124R|SARDH_ENST00000439388.1_Missense_Mutation_p.H292R	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	292					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		ATAGGCATGGTGCATGGCCAC	0.632000													6	116					0	0	1	0	0
USP1	7398	broad.mit.edu	37	1	62916129	62916129	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:62916129A>G	ENST00000339950.4	+	9	2650	c.1835A>G	c.(1834-1836)aAt>aGt	p.N612S	USP1_ENST00000371146.1_Missense_Mutation_p.N612S	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1	612					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		GATAAAGGAAATTTTGTGGTT	0.388000													4	91					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955628	18955628	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18955628T>C	ENST00000302797.3	-	1	928	c.704A>G	c.(703-705)cAg>cGg	p.Q235R		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	235					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TAGGAAAAACTGAATGCCAAA	0.478000													7	45					0	0	1	0	0
NUP88	4927	broad.mit.edu	37	17	5312177	5312177	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:5312177G>C	ENST00000573584.1	-	5	1242	c.733C>G	c.(733-735)Cca>Gca	p.P245A		NM_002532.4	NP_002523.2	Q99567	NUP88_HUMAN	nucleoporin 88kDa	245					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			endometrium(4)|kidney(4)|large_intestine(4)|lung(3)	15						GCTGCCAATGGCCCAAAGTCA	0.408000													23	52					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150931160	150931160	+	Silent	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150931160T>G	ENST00000035307.2	+	1	1576	c.63T>G	c.(61-63)tcT>tcG	p.S21S	CHPF2_ENST00000495645.1_Intron	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	21						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						TAGGGCTGTCTCTGGGGTGCA	0.657000													27	75					0	0	1	0	0
CHD1L	9557	broad.mit.edu	37	1	146765320	146765320	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:146765320A>C	ENST00000369258.4	+	21	2440	c.2420A>C	c.(2419-2421)gAt>gCt	p.D807A	CHD1L_ENST00000369259.3_Missense_Mutation_p.D603A|CHD1L_ENST00000467213.1_3'UTR|CHD1L_ENST00000361293.5_Missense_Mutation_p.D526A|CHD1L_ENST00000431239.1_Missense_Mutation_p.D713A	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	807	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					CAGCATCGTGATCGTTCCAAT	0.473000													31	149					0	0	1	0	0
BCL2L13	23786	broad.mit.edu	37	22	18209480	18209480	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:18209480A>G	ENST00000355028.3	+	5	550	c.424A>G	c.(424-426)Acc>Gcc	p.T142A	BCL2L13_ENST00000317582.5_Missense_Mutation_p.Y213C|BCL2L13_ENST00000538149.1_Missense_Mutation_p.Y89C|BCL2L13_ENST00000337612.5_Missense_Mutation_p.Y51C|BCL2L13_ENST00000418951.2_3'UTR|BCL2L13_ENST00000543133.1_Missense_Mutation_p.Y51C|BCL2L13_ENST00000485631.1_3'UTR	NM_001270733.1|NM_001270734.1	NP_001257662.1|NP_001257663.1	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	357					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		GAGGAGGAATACCCTGGAATC	0.438000													21	48					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7780604	7780604	+	Splice_Site	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:7780604C>A	ENST00000420658.1	-	14	2055		c.e14-1		AFAP1_ENST00000513842.1_Splice_Site|AFAP1_ENST00000360265.4_Splice_Site|AFAP1_ENST00000358461.2_Splice_Site|AFAP1_ENST00000382543.3_Splice_Site	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1							actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						TACCCTTGAGCTGTTGAAATA	0.408000													11	116					0.00136819	0.00138229	1	1	0
A2M	2	broad.mit.edu	37	12	9254095	9254095	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:9254095A>C	ENST00000318602.7	-	12	1749	c.1442T>G	c.(1441-1443)aTt>aGt	p.I481S		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	481					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	TCCATTCAGAATATAATGTGC	0.493000													11	59					0	0	1	0	0
GSX1	219409	broad.mit.edu	37	13	28368040	28368040	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:28368040G>A	ENST00000302945.2	+	2	798	c.750G>A	c.(748-750)ccG>ccA	p.P250P		NM_145657.1	NP_663632.1	Q9H4S2	GSX1_HUMAN	GS homeobox 1	250					positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)	4		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CCATGTCTCCGTCCTCCTCAG	0.657000													23	45					0	0	1	0	0
ALLC	55821	broad.mit.edu	37	2	3750034	3750034	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:3750034G>A	ENST00000252505.3	+	12	1219	c.1057G>A	c.(1057-1059)Gtc>Atc	p.V353I	ALLC_ENST00000471711.1_3'UTR	NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	372							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		GCTCACCATCGTCCCCGACGG	0.597000										HNSCC(21;0.051)			12	33					0	0	1	0	0
QRSL1	55278	broad.mit.edu	37	6	107090875	107090875	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:107090875T>C	ENST00000369046.4	+	4	394	c.290T>C	c.(289-291)aTa>aCa	p.I97T	QRSL1_ENST00000369044.1_Missense_Mutation_p.I97T	NM_018292.4	NP_060762.3	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	97					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor			endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		TCAGGTTATATACCACCTTAT	0.318000													13	42					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17699907	17699907	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:17699907T>C	ENST00000353383.1	+	3	4114	c.3645T>C	c.(3643-3645)tcT>tcC	p.S1215S	RAI1_ENST00000261641.6_Silent_p.S1215S	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1215						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GCAAGCTCTCTGACCGGCCCC	0.652000													22	77					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11107214	11107214	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11107214T>C	ENST00000358026.2	+	11	2090	c.1806T>C	c.(1804-1806)gaT>gaC	p.D602D	SMARCA4_ENST00000541122.2_Silent_p.D602D|SMARCA4_ENST00000344626.4_Silent_p.D602D|SMARCA4_ENST00000450717.3_Silent_p.D602D|SMARCA4_ENST00000590574.1_Silent_p.D602D|SMARCA4_ENST00000589677.1_Silent_p.D602D|SMARCA4_ENST00000444061.3_Silent_p.D602D|SMARCA4_ENST00000413806.3_Silent_p.D602D|SMARCA4_ENST00000429416.3_Silent_p.D602D	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	602					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TTGGGCCGGATGGCGAGGTGA	0.507000			"""F, N, Mis"""		NSCLC								30	117					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23862231	23862231	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23862231G>A	ENST00000405093.3	-	24	3211	c.3141C>T	c.(3139-3141)cgC>cgT	p.R1047R	MYH6_ENST00000356287.3_Silent_p.R1047R	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1047					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCAGGTCCATGCGCACCTTCT	0.493000													29	80					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23702298	23702298	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:23702298C>T	ENST00000256797.4	-	22	2947	c.2779G>A	c.(2779-2781)Gtc>Atc	p.V927I	ERN2_ENST00000457008.2_Missense_Mutation_p.V827I	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	879					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AAGTACTGGACGAAGCCATCA	0.617000													5	96					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188533	152188533	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152188533T>C	ENST00000368801.2	-	3	5647	c.5572A>G	c.(5572-5574)Agt>Ggt	p.S1858G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1858					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCGGCCACTGCTGGAAGAC	0.592000													71	1876					0	0	1	0	0
HADH	3033	broad.mit.edu	37	4	108935639	108935639	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:108935639A>G	ENST00000505878.1	+	4	599	c.326A>G	c.(325-327)gAt>gGt	p.D109G	HADH_ENST00000403312.1_Missense_Mutation_p.D164G|HADH_ENST00000309522.3_Missense_Mutation_p.D105G|HADH_ENST00000603302.1_Missense_Mutation_p.D105G|HADH_ENST00000454409.2_Missense_Mutation_p.D109G			Q16836	HCDH_HUMAN	hydroxyacyl-CoA dehydrogenase	105					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	15		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	ACCAGCACGGATGCAGCCTCC	0.527000													41	143					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196788388	196788388	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:196788388T>C	ENST00000312428.6	-	23	3856	c.3756A>G	c.(3754-3756)tcA>tcG	p.S1252S		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1252	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTTTTACAAGTGATGAGAGGA	0.408000													10	64					0	0	1	0	0
PBK	55872	broad.mit.edu	37	8	27668686	27668686	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:27668686T>C	ENST00000522944.1	-	7	988		c.e7-2		PBK_ENST00000301905.4_Intron|ESCO2_ENST00000397418.2_Intron			Q96KB5	TOPK_HUMAN	PDZ binding kinase						mitosis		ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(1)|large_intestine(2)|lung(1)	4		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)		AGGCAGGAGctacaaatcacg	0.443000													9	36					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71348618	71348618	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:71348618C>T	ENST00000392650.3	-	41	5752	c.5752G>A	c.(5752-5754)Gtg>Atg	p.V1918M	SDK2_ENST00000410094.1_5'UTR|SDK2_ENST00000388726.3_Missense_Mutation_p.V1899M	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1918	Fibronectin type-III 13.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTACCTGGCACAGACTGGGAG	0.667000													7	22					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72192975	72192975	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:72192975A>G	ENST00000337273.5	+	20	2761	c.2335A>G	c.(2335-2337)Aca>Gca	p.T779A	TNPO1_ENST00000523768.1_Missense_Mutation_p.T729A|TNPO1_ENST00000454282.1_Missense_Mutation_p.T729A|TNPO1_ENST00000506351.2_Missense_Mutation_p.T771A	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	779					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		GTTAGAGAATACAGGTACCAT	0.358000													8	63					0	0	1	0	0
SUV420H2	84787	broad.mit.edu	37	19	55854170	55854170	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55854170C>A	ENST00000255613.3	+	4	585	c.337C>A	c.(337-339)Cgc>Agc	p.R113S	AC020922.1_ENST00000539076.1_Intron|SUV420H2_ENST00000402499.4_Intron	NM_032701.3	NP_116090.2	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2 (Drosophila)	113	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	4	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GCCCTGCACGCGCTACTCCAT	0.622000													4	75					1	1	1	1	0
PCDHA1	56147	broad.mit.edu	37	5	140166235	140166235	+	Missense_Mutation	SNP	G	G	C	rs138016369	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140166235G>C	ENST00000504120.2	+	1	360	c.360G>C	c.(358-360)gaG>gaC	p.E120D	PCDHA1_ENST00000378133.3_Missense_Mutation_p.E120D|PCDHA1_ENST00000394633.3_Missense_Mutation_p.E120D	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCATGTGGAGGTGAAGGTGA	0.512000													37	137					0	0	1	0	0
MAT2A	4144	broad.mit.edu	37	2	85769463	85769463	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:85769463G>A	ENST00000306434.3	+	6	858	c.735G>A	c.(733-735)caG>caA	p.Q245Q	MAT2A_ENST00000409017.1_Silent_p.Q182Q	NM_005911.5	NP_005902.1	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	245					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	9					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	ACCACCTACAGCCAAGTGGCA	0.393000													11	49					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22625244	22625244	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:22625244T>C	ENST00000333957.4	-	18	2400	c.2145A>G	c.(2143-2145)atA>atG	p.I715M	C2CD5_ENST00000396028.2_Missense_Mutation_p.I706M|C2CD5_ENST00000446597.1_Missense_Mutation_p.I715M|C2CD5_ENST00000544930.1_Missense_Mutation_p.I530M|C2CD5_ENST00000545552.1_Missense_Mutation_p.I728M|C2CD5_ENST00000542676.1_Missense_Mutation_p.I715M|C2CD5_ENST00000536386.1_Missense_Mutation_p.I717M	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		TCCAATTATTTATACCGGGCA	0.239000													6	12					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596148	58596148	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58596148C>T	ENST00000240727.6	-	7	1836	c.1437G>A	c.(1435-1437)ccG>ccA	p.P479P	ZSCAN18_ENST00000600404.1_Silent_p.P535P|ZSCAN18_ENST00000601144.1_Silent_p.P479P|ZSCAN18_ENST00000421612.2_Silent_p.P343P	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	479					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CGCGGGTGGACGGTTGGGGGC	0.726000													6	15					0	0	1	0	0
SLC4A9	83697	broad.mit.edu	37	5	139752342	139752342	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:139752342T>C	ENST00000230993.6	+	21	2946	c.2911T>C	c.(2911-2913)Tat>Cat	p.Y971H	SLC4A9_ENST00000432095.2_Missense_Mutation_p.Y933H|CTC-329D1.2_ENST00000507521.1_RNA|SLC4A9_ENST00000507527.1_Missense_Mutation_p.Y971H|SLC4A9_ENST00000506757.2_Missense_Mutation_p.Y947H|SLC4A9_ENST00000506545.1_Missense_Mutation_p.Y884H	NM_001258428.1	NP_001245357.1	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 9	971	Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGCTGATGTATCAGCCAAA	0.463000											OREG0016847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	5					0	0	1	0	0
RRAGC	64121	broad.mit.edu	37	1	39322560	39322560	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:39322560A>G	ENST00000373001.3	-	2	608	c.432T>C	c.(430-432)atT>atC	p.I144I		NM_022157.2	NP_071440.1	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	144					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)	10	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				CCTGTGCGTCAATGACGTATA	0.403000													36	83					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100955744	100955744	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:100955744C>T	ENST00000548884.1	+	10	1689	c.1148C>T	c.(1147-1149)gCt>gTt	p.A383V	NR1H4_ENST00000549996.1_Missense_Mutation_p.A336V|NR1H4_ENST00000188403.7_Missense_Mutation_p.A393V|NR1H4_ENST00000551379.1_Missense_Mutation_p.A397V|NR1H4_ENST00000392986.3_Missense_Mutation_p.A387V	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	397	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						GAGGAGTATGCTCTGCTTACA	0.323000													4	81					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233404727	233404727	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233404727G>T	ENST00000389494.3	+	2	102	c.81G>T	c.(79-81)gaG>gaT	p.E27D	CHRNG_ENST00000389492.3_Missense_Mutation_p.E27D	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	27					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		ACCAGGAGGAGCGCCTGCTCG	0.632000													17	51					1.67942e-08	1.73241e-08	1	1	0
TAF10	6881	broad.mit.edu	37	11	6632999	6632999	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:6632999C>A	ENST00000299424.4	-	2	760	c.283G>T	c.(283-285)Ggg>Tgg	p.G95W	TAF10_ENST00000531760.1_5'UTR	NM_006284.3	NP_006275.1	Q12962	TAF10_HUMAN	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	95					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity						Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACGTAAACCCCGTTAGATATG	0.647000													8	23					5.18039e-06	5.29904e-06	1	1	0
LUZP1	7798	broad.mit.edu	37	1	23419686	23419686	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:23419686C>T	ENST00000302291.4	-	4	1870	c.1069G>A	c.(1069-1071)Gag>Aag	p.E357K	LUZP1_ENST00000374623.3_Missense_Mutation_p.E357K|LUZP1_ENST00000418342.1_Missense_Mutation_p.E357K|LUZP1_ENST00000314174.5_Missense_Mutation_p.E357K			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	357						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		CCTTCTACCTCTCCATTTTCT	0.418000													29	58					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8479020	8479020	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:8479020A>G	ENST00000447869.1	-	5	1483	c.565T>C	c.(565-567)Tac>Cac	p.Y189H	STK33_ENST00000396672.1_Missense_Mutation_p.Y189H|STK33_ENST00000534493.1_Missense_Mutation_p.Y148H|STK33_ENST00000396673.1_Missense_Mutation_p.Y189H|STK33_ENST00000315204.1_Missense_Mutation_p.Y189H|STK33_ENST00000358872.3_Missense_Mutation_p.Y2H			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	189	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		ATCACAAGGTACATTTTCTGA	0.338000													16	41					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70224303	70224303	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:70224303T>C	ENST00000253925.7	+	26	3765		c.e26+2		PPFIA1_ENST00000389547.3_Silent_p.G1184G|AP000487.5_ENST00000530690.1_RNA|AP000487.5_ENST00000500185.2_RNA|PPFIA1_ENST00000530548.1_Splice_Site	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1						cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AGATGGACGGTATGTGATGGG	0.463000													21	71					0	0	1	0	0
MYO1D	4642	broad.mit.edu	37	17	30821922	30821922	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:30821922T>C	ENST00000318217.5	-	22	3180	c.2876A>G	c.(2875-2877)cAc>cGc	p.H959R	MYO1D_ENST00000394649.4_Missense_Mutation_p.H871R	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	959						myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CACTTGAAGGTGGCGCTTCTC	0.622000													17	73					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799272	140799272	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140799272C>A	ENST00000398594.2	+	1	1846	c.1846C>A	c.(1846-1848)Ctc>Atc	p.L616I	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCCCGGGCTCTTCAGCCT	0.662000													44	124					2.13384e-23	2.25745e-23	1	1	0
NLRP12	91662	broad.mit.edu	37	19	54308536	54308536	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54308536A>G	ENST00000324134.6	-	5	2580	c.2412T>C	c.(2410-2412)atT>atC	p.I804I	NLRP12_ENST00000354278.3_Silent_p.I804I|NLRP12_ENST00000351894.4_Silent_p.I804I|NLRP12_ENST00000345770.5_Silent_p.I805I|NLRP12_ENST00000391772.1_Silent_p.I805I|NLRP12_ENST00000391773.1_Silent_p.I805I|NLRP12_ENST00000535162.1_Silent_p.I804I|NLRP12_ENST00000391775.3_Silent_p.I804I	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	804					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGACTCACTGAATCATCTGCA	0.507000													24	99					0	0	1	0	0
ZNF70	7621	broad.mit.edu	37	22	24086066	24086066	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:24086066C>T	ENST00000341976.3	-	2	1722	c.1262G>A	c.(1261-1263)tGc>tAc	p.C421Y		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	421						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						GCACAGATTGCACACGTAGGG	0.557000													5	232					0	0	1	0	0
ANXA2R	389289	broad.mit.edu	37	5	43039613	43039613	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:43039613A>G	ENST00000314890.3	-	2	1955	c.536T>C	c.(535-537)gTa>gCa	p.V179A		NM_001014279.2	NP_001014301.1	Q3ZCQ2	AX2R_HUMAN	annexin A2 receptor	179							receptor activity										CGCCCAGAGTACAGAGAACGC	0.557000											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	131					0	0	1	0	0
TCEA1	6917	broad.mit.edu	37	8	54883013	54883013	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:54883013C>T	ENST00000521604.2	-	9	1239	c.836G>A	c.(835-837)cGt>cAt	p.R279H	TCEA1_ENST00000521086.2_5'UTR|TCEA1_ENST00000522635.1_Missense_Mutation_p.R95H|TCEA1_ENST00000396401.3_Missense_Mutation_p.R258H	NM_006756.2	NP_006747.1	P23193	TCEA1_HUMAN	transcription elongation factor A (SII), 1	279					positive regulation of viral transcription|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|translation elongation factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;9.1e-07)|Epithelial(17;9.44e-05)|all cancers(17;0.000699)			ATCAGCACTACGGGTTTGTAC	0.303000			T	PLAG1	salivary adenoma								11	16					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101523854	101523854	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:101523854C>T	ENST00000284395.5	+	4	702	c.302C>T	c.(301-303)gCg>gTg	p.A101V	LRRK1_ENST00000388948.3_Missense_Mutation_p.A128V|LRRK1_ENST00000532029.2_Missense_Mutation_p.A128V			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	128					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTGGTGGCAGCGTATTTTGGA	0.567000													15	76					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286062	48286062	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:48286062T>C	ENST00000320048.1	+	1	650	c.650T>C	c.(649-651)cTg>cCg	p.L217P		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GCTTCCTACCTGATCATCCTG	0.542000													4	84					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135202471	135202471	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:135202471T>C	ENST00000278060.5	+	5	1216	c.1133T>C	c.(1132-1134)gTt>gCt	p.V378A	PAOX_ENST00000368539.4_3'UTR|PAOX_ENST00000480071.2_Missense_Mutation_p.F294L|PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000357296.3_Missense_Mutation_p.V378A	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	516					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TCTGTCCACGTTCTCTGTGGG	0.537000													29	543					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127681179	127681179	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:127681179G>A	ENST00000508053.1	-	30	4061	c.3087C>T	c.(3085-3087)gtC>gtT	p.V1029V	FBN2_ENST00000508989.1_Silent_p.V996V|FBN2_ENST00000262464.4_Silent_p.V1029V			P35556	FBN2_HUMAN	fibrillin 2	1029	TB 5.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AAGCCGCCCCGACAGCACAGC	0.592000													51	144					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3294277	3294277	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3294277C>T	ENST00000219596.1	-	8	1775	c.1736G>A	c.(1735-1737)cGt>cAt	p.R579H	MEFV_ENST00000536379.1_Missense_Mutation_p.R368H|MEFV_ENST00000339854.4_Missense_Mutation_p.R399H|MEFV_ENST00000541159.1_Missense_Mutation_p.R368H	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	579					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding	p.R579H(1)		NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	CATTTCTGAACGCAGGGTTTC	0.532000													14	32					0	0	1	0	0
HRH2	3274	broad.mit.edu	37	5	175110376	175110376	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:175110376G>A	ENST00000231683.2	+	1	1913	c.140G>A	c.(139-141)cGc>cAc	p.R47H	HRH2_ENST00000377291.2_Missense_Mutation_p.R47H	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	47					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	GGCTTGAACCGCCGGCTCCGC	0.587000													65	112					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24193018	24193018	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:24193018G>A	ENST00000265769.4	+	14	1541	c.1431G>A	c.(1429-1431)atG>atA	p.M477I	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.M224I|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000437154.2_Missense_Mutation_p.M477I|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000540823.1_Missense_Mutation_p.M244I	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	477	Disintegrin.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGCCTGAAATGTGTAATGGTA	0.453000													10	44					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554771	140554771	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140554771C>T	ENST00000231137.3	+	1	2529	c.2355C>T	c.(2353-2355)cgC>cgT	p.R785R		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		785					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGAAAATCGCCCATTTCAGA	0.448000													12	413					0	0	1	0	0
ZNF684	127396	broad.mit.edu	37	1	41012511	41012511	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:41012511T>C	ENST00000372699.3	+	5	767	c.516T>C	c.(514-516)ttT>ttC	p.F172F	ZNF684_ENST00000493756.1_3'UTR	NM_152373.3	NP_689586.3	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|lung(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			AAAAGAAGTTTCATTTCATTA	0.348000													18	50					0	0	1	0	0
SLMO2	51012	broad.mit.edu	37	20	57613590	57613590	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:57613590A>C	ENST00000355937.4	-	2	310	c.132T>G	c.(130-132)gaT>gaG	p.D44E	SLMO2_ENST00000371033.5_Missense_Mutation_p.D44E	NM_016045.2	NP_057129.2	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2 (Drosophila)	44	PRELI/MSF1.									endometrium(1)|lung(2)|skin(2)	5	all_lung(29;0.00711)		Colorectal(105;0.109)			TTCCAGAGGGATCTATATGTC	0.483000													14	175					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757839	757839	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:757839G>A	ENST00000215582.6	+	2	996	c.893G>A	c.(892-894)cGt>cAt	p.R298H		NM_173481.2	NP_775752.1			mitotic spindle positioning																		CGGGAGATCCGTCTGGCTCAG	0.672000													27	79					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169718498	169718498	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:169718498A>G	ENST00000444448.2	+	18	1970	c.1494A>G	c.(1492-1494)agA>agG	p.R498R	NOSTRIN_ENST00000397206.2_Silent_p.R363R|NOSTRIN_ENST00000397209.2_Silent_p.R413R|NOSTRIN_ENST00000317647.7_Silent_p.R441R|NOSTRIN_ENST00000445023.2_Silent_p.R363R|NOSTRIN_ENST00000421711.2_Silent_p.R413R|NOSTRIN_ENST00000458381.2_Silent_p.R498R			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	441					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						TCAGCAGCAGACTTTGCAAGG	0.408000													9	97					0	0	1	0	0
PEBP4	157310	broad.mit.edu	37	8	22785223	22785223	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:22785223C>T	ENST00000256404.6	-	2	96	c.5G>A	c.(4-6)gGt>gAt	p.G2D	PEBP4_ENST00000521284.1_5'UTR	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	2						lysosome				breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		CATTGTCCAACCCATGGGCAC	0.612000													30	94					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6732499	6732499	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:6732499T>C	ENST00000264080.7	-	11	1021	c.995A>G	c.(994-996)tAc>tGc	p.Y332C	GPR108_ENST00000430424.4_Missense_Mutation_p.Y90C	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	332						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						GTGTGCGATGTAGTACATGAC	0.627000													21	69					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100279806	100279806	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100279806G>A	ENST00000275732.5	-	22	4023	c.2814C>T	c.(2812-2814)caC>caT	p.H938H		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	938										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGATATAATCGTGGACATCAT	0.597000													41	121					0	0	1	0	0
AP4B1	10717	broad.mit.edu	37	1	114440480	114440480	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:114440480C>G	ENST00000369569.1	-	7	1564	c.1284G>C	c.(1282-1284)gaG>gaC	p.E428D	AP4B1-AS1_ENST00000419536.1_RNA|AP4B1_ENST00000256658.4_Missense_Mutation_p.E428D|AP4B1_ENST00000462591.1_5'UTR|AP4B1_ENST00000369567.1_Missense_Mutation_p.E260D	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	428					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTGAATGTTCTCTTCACAGC	0.468000													30	77					0	0	1	0	0
CCNA2	890	broad.mit.edu	37	4	122739319	122739319	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:122739319A>T	ENST00000274026.5	-	7	1433	c.1130T>A	c.(1129-1131)aTa>aAa	p.I377K		NM_001237.3	NP_001228.1	P20248	CCNA2_HUMAN	cyclin A2	377					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	12						AGTCTTTCGTATTAATGATTC	0.408000													4	179					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7110662	7110662	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:7110662G>A	ENST00000306904.5	+	1	498	c.311G>A	c.(310-312)cGc>cAc	p.R104H		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	104	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCCGCGGTCGCCCGAGGTTC	0.751000													3	5					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123343659	123343659	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123343659G>C	ENST00000253083.4	+	22	2335	c.2210G>C	c.(2209-2211)gGg>gCg	p.G737A		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	737					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		GAGCTCATGGGGCAGCTGCAG	0.687000													4	17					0	0	1	0	0
CLPX	10845	broad.mit.edu	37	15	65450102	65450102	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:65450102C>T	ENST00000300107.3	-	8	1227	c.1039G>A	c.(1039-1041)Gtg>Atg	p.V347M		NM_006660.3	NP_006651.2	O76031	CLPX_HUMAN	caseinolytic mitochondrial matrix peptidase chaperone subunit	347					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)|skin(2)	16						GCTTTTTCCACATTATAATTG	0.358000													48	90					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122612496	122612496	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:122612496A>G	ENST00000319080.6	+	3	719	c.587A>G	c.(586-588)gAc>gGc	p.D196G				Q9HAP2	MLXIP_HUMAN	MLX interacting protein	196	Required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GTGGACGTAGACGAGCACCGC	0.607000													10	267					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126749132	126749132	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:126749132G>C	ENST00000393409.2	+	28	5108	c.5108G>C	c.(5107-5109)aGc>aCc	p.S1703T	PLXNA1_ENST00000251772.4_Missense_Mutation_p.S1680T	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1703					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		ACCATCTTCAGCACGGCACAC	0.627000													43	127					0	0	1	0	0
IRS2	8660	broad.mit.edu	37	13	110436745	110436745	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:110436745A>G	ENST00000375856.3	-	1	2170	c.1656T>C	c.(1654-1656)tgT>tgC	p.C552C		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	552					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			AGGAGCGGCCACAGTGGCTCA	0.731000													13	41					0	0	1	0	0
HNRNPD	3184	broad.mit.edu	37	4	83279810	83279810	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:83279810A>G	ENST00000313899.7	-	4	899		c.e4+1		HNRNPD_ENST00000353341.4_Splice_Site|HNRNPD_ENST00000352301.4_Splice_Site|HNRNPD_ENST00000543098.1_Splice_Site|HNRNPD_ENST00000541060.1_Splice_Site	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)						nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						TTTATAACATACCTCACCAAA	0.373000													29	90					0	0	1	0	0
DCK	1633	broad.mit.edu	37	4	71888147	71888147	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:71888147C>T	ENST00000286648.5	+	3	668	c.271C>T	c.(271-273)Cga>Tga	p.R91*	DCK_ENST00000504952.1_Nonsense_Mutation_p.R91*|MOB1B_ENST00000511449.1_3'UTR|DCK_ENST00000504730.1_Nonsense_Mutation_p.R91*	NM_000788.2	NP_000779.1	P27707	DCK_HUMAN	deoxycytidine kinase	91					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)	9			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	GAAACCTGAACGATGGTCTTT	0.378000													6	107					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	905684	905684	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:905684T>C	ENST00000456758.2	+	22	2527	c.2527T>C	c.(2527-2529)Tcc>Ccc	p.S843P	SUN1_ENST00000452783.2_Missense_Mutation_p.S551P|SUN1_ENST00000389574.3_Missense_Mutation_p.S571P|SUN1_ENST00000405266.1_Missense_Mutation_p.S691P|SUN1_ENST00000413514.2_Missense_Mutation_p.S452P|SUN1_ENST00000425407.2_Missense_Mutation_p.S571P|SUN1_ENST00000401592.1_Missense_Mutation_p.S654P			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	681					cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTTCTCGCAGTCCCCGCGCGT	0.577000													25	47					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202626476	202626476	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:202626476T>C	ENST00000264276.6	-	4	613	c.241A>G	c.(241-243)Agc>Ggc	p.S81G	ALS2_ENST00000496244.1_5'UTR|ALS2_ENST00000467448.1_Missense_Mutation_p.S81G	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	81					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						AGAATGGGGCTACTTGGACAA	0.433000													19	135					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85530594	85530594	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:85530594G>A	ENST00000295887.5	+	3	681	c.258G>A	c.(256-258)tgG>tgA	p.W86*		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	86					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GGAAAAACTGGTGGATACGTG	0.333000													21	64					0	0	1	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35568532	35568532	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:35568532T>C	ENST00000261475.5	-	7	985	c.632A>G	c.(631-633)gAa>gGa	p.E211G		NM_017917.2	NP_060387.2	Q969Q6	P2R3C_HUMAN	protein phosphatase 2, regulatory subunit B'', gamma	211						centrosome|nucleus	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)	15	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		GAAAGATTTTTCCAGACCATC	0.308000													15	32					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33644452	33644452	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:33644452G>A	ENST00000399362.4	-	18	2269	c.1916C>T	c.(1915-1917)gCg>gTg	p.A639V	CLASP2_ENST00000333778.6_Missense_Mutation_p.A416V|CLASP2_ENST00000487200.1_Missense_Mutation_p.A412V|CLASP2_ENST00000359576.5_Missense_Mutation_p.A639V|CLASP2_ENST00000307312.7_Missense_Mutation_p.A128V|CLASP2_ENST00000539981.1_Missense_Mutation_p.A391V|CLASP2_ENST00000480013.1_Missense_Mutation_p.A406V|CLASP2_ENST00000468888.2_Missense_Mutation_p.A640V|CLASP2_ENST00000313350.6_Missense_Mutation_p.A412V|CLASP2_ENST00000461133.3_Missense_Mutation_p.A406V	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	640										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						ACCTAGTGACGCATAGGAACC	0.468000													8	13					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107594013	107594013	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:107594013A>G	ENST00000374736.3	-	13	1999	c.1605T>C	c.(1603-1605)ggT>ggC	p.G535G		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	535					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGAACACAATACCAGCCCAGA	0.463000													27	88					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537624	24537624	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:24537624C>T	ENST00000264463.4	-	3	898	c.391G>A	c.(391-393)Gct>Act	p.A131T		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	131	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTGTTAATAGCTTGTGCGCGT	0.398000										HNSCC(23;0.051)			50	115					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196735731	196735731	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:196735731T>C	ENST00000296350.5	-	12	1744	c.1631A>G	c.(1630-1632)aAg>aGg	p.K544R		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	544	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GCCCACACACTTGTTGCGGCC	0.647000													10	129					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953025	56953025	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56953025T>C	ENST00000504904.3	-	7	2058	c.1339A>G	c.(1339-1341)Aaa>Gaa	p.K447E	ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000342634.3_Missense_Mutation_p.K575E|ZNF667_ENST00000292069.6_Missense_Mutation_p.K447E			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTACTACATTTATTGCATTTG	0.353000													5	47					0	0	1	0	0
HNRNPC	3183	broad.mit.edu	37	14	21681250	21681250	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21681250G>A	ENST00000430246.2	-	5	3343	c.392C>T	c.(391-393)cCt>cTt	p.P131L	HNRNPC_ENST00000555914.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000320084.7_Missense_Mutation_p.P144L|HNRNPC_ENST00000555883.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000555309.1_Missense_Mutation_p.P144L|HNRNPC_ENST00000554969.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000336053.6_Missense_Mutation_p.P131L|HNRNPC_ENST00000554455.1_Missense_Mutation_p.P144L|HNRNPC_ENST00000553753.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000556628.1_Missense_Mutation_p.P64L|HNRNPC_ENST00000449098.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000553300.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000420743.2_Missense_Mutation_p.P144L|HNRNPC_ENST00000557201.1_Missense_Mutation_p.P144L|HNRNPC_ENST00000556897.1_Missense_Mutation_p.P131L|HNRNPC_ENST00000556513.1_Missense_Mutation_p.P144L|HNRNPC_ENST00000556142.1_Missense_Mutation_p.P144L			P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C (C1/C2)	144						catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding			breast(1)|liver(1)|lung(6)|skin(1)	9	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		AGGAGGAGGAGGTACACGTGC	0.443000													45	75					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969130	47969130	+	Silent	SNP	G	G	A	rs118059830	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:47969130G>A	ENST00000236877.6	-	2	926	c.531C>T	c.(529-531)atC>atT	p.I177I	SLC8A2_ENST00000539381.1_Intron|SLC8A2_ENST00000542837.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	177					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TGCACACGGCGATGACCACAA	0.582000													18	46					0	0	1	0	0
RCL1	10171	broad.mit.edu	37	9	4826916	4826916	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:4826916T>C	ENST00000381750.4	+	3	490	c.267T>C	c.(265-267)tgT>tgC	p.C89C	RCL1_ENST00000381732.3_Silent_p.C89C	NM_005772.3	NP_005763.3	Q9Y2P8	RCL1_HUMAN	RNA terminal phosphate cyclase-like 1	89					ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity			breast(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)		AACATGACTGTAGCGTCCTTC	0.438000													26	252					0	0	1	0	0
TBX22	50945	broad.mit.edu	37	X	79286155	79286155	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:79286155C>T	ENST00000442340.1	+	9	1238	c.748C>T	c.(748-750)Cct>Tct	p.P250S	TBX22_ENST00000373291.1_Missense_Mutation_p.P250S|TBX22_ENST00000373294.5_Missense_Mutation_p.P370S|TBX22_ENST00000373296.3_Missense_Mutation_p.P370S	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	370					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTCAACCTGCCTCTATGCTA	0.448000													41	64					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61574234	61574234	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:61574234C>T	ENST00000577647.1	+	13	1902	c.1857C>T	c.(1855-1857)agC>agT	p.S619S	ACE_ENST00000290866.4_Silent_p.S1193S|ACE_ENST00000428043.1_Intron|ACE_ENST00000421982.2_Silent_p.S398S|ACE_ENST00000290863.6_Silent_p.S619S|ACE_ENST00000413513.3_Silent_p.S578S|ACE_ENST00000490216.2_Silent_p.S619S			P12821	ACE_HUMAN	angiotensin I converting enzyme	1193	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCAACATGAGCGCCTCGGCCA	0.642000													15	40					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768737	140768737	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140768737C>T	ENST00000519479.1	+	1	1286	c.1286C>T	c.(1285-1287)cCc>cTc	p.P429L	PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCAAGCCTCCCCTCTCCTCC	0.488000													5	228					0	0	1	0	0
CHST5	23563	broad.mit.edu	37	16	75563688	75563688	+	Missense_Mutation	SNP	G	G	A	rs147059773		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:75563688G>A	ENST00000336257.3	-	3	1989	c.595C>T	c.(595-597)Cgc>Tgc	p.R199C	RP11-77K12.7_ENST00000460606.1_3'UTR|CHST5_ENST00000541075.1_Missense_Mutation_p.R205C	NM_024533.4	NP_078809.2	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	199					N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)	24						TTGAAGAAGCGCACCTCCTTG	0.677000													65	192					0	0	1	0	0
CLEC4G	339390	broad.mit.edu	37	19	7795312	7795312	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7795312C>T	ENST00000328853.5	-	6	471	c.403G>A	c.(403-405)Gct>Act	p.A135T		NM_001244856.1|NM_198492.3	NP_001231785.1|NP_940894.1	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	135						integral to membrane	protein binding|sugar binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(1)	6						CCGGCTTCAGCCAAGCCCTGG	0.677000													11	43					0	0	1	0	0
NPDC1	56654	broad.mit.edu	37	9	139935003	139935003	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139935003G>A	ENST00000371600.3	-	5	1577	c.905C>T	c.(904-906)gCg>gTg	p.A302V	NPDC1_ENST00000371601.4_Missense_Mutation_p.A224V			Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and control, 1	224						integral to membrane				NS(1)|large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	5	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		AGGGGCCTTCGCAGTGGCGTA	0.687000													4	13					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54967630	54967630	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54967630G>A	ENST00000326764.5	+	10	1910	c.1431G>A	c.(1429-1431)gcG>gcA	p.A477A	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	440							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GAGGCAGGGCGCAGCGTGGGA	0.687000													4	21					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140500208	140500208	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:140500208G>T	ENST00000288602.6	-	7	994	c.934C>A	c.(934-936)Cta>Ata	p.L312I		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	312					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	CCAGATGTTAGGGCAGTCTCT	0.488000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				25	88					4.47668e-21	4.72492e-21	1	1	0
FARP1	10160	broad.mit.edu	37	13	99047677	99047677	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:99047677T>C	ENST00000376586.2	+	13	1697	c.1361T>C	c.(1360-1362)gTc>gCc	p.V454A	FARP1_ENST00000319562.6_Missense_Mutation_p.V454A|FARP1_ENST00000595437.1_Missense_Mutation_p.V454A			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	454					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GAGGAGGAGGTCGTTAAGGAT	0.667000													23	109					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043570	71043570	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:71043570C>T	ENST00000272367.2	-	4	1019	c.943G>A	c.(943-945)Gct>Act	p.A315T	CLEC4F_ENST00000426626.1_Missense_Mutation_p.A315T	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	315					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TGGATCTCAGCACTAGTGTTG	0.413000													30	119					0	0	1	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62885895	62885895	+	Silent	SNP	G	G	A	rs141158169		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:62885895G>A	ENST00000253401.6	-	7	1727	c.927C>T	c.(925-927)ggC>ggT	p.G309G	ARHGEF9_ENST00000374878.1_Silent_p.G307G|ARHGEF9_ENST00000437457.2_Silent_p.G256G|ARHGEF9_ENST00000433323.2_Intron|ARHGEF9_ENST00000374870.4_Silent_p.G207G|ARHGEF9_ENST00000374872.1_Silent_p.G288G|ARHGEF9_ENST00000495564.1_Intron	NM_015185.2	NP_056000.1	O43307	ARHG9_HUMAN	Cdc42 guanine nucleotide exchange factor (GEF) 9	309					apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|skin(1)	35						GGATGTCCTCGCCCTGGGAAG	0.597000													22	23					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27348771	27348771	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:27348771C>T	ENST00000521400.1	+	1	476	c.46C>T	c.(46-48)Ctg>Ttg	p.L16L	EPHX2_ENST00000520666.1_3'UTR|EPHX2_ENST00000521780.1_5'UTR|EPHX2_ENST00000518379.1_Silent_p.L16L|EPHX2_ENST00000517536.1_Silent_p.L16L|EPHX2_ENST00000380476.3_5'UTR	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	16	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GGTGCTGGCGCTGCCAGCGGT	0.746000													4	25					0	0	1	0	0
RAB10	10890	broad.mit.edu	37	2	26357811	26357811	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:26357811C>A	ENST00000264710.4	+	6	1023	c.524C>A	c.(523-525)cCt>cAt	p.P175H	RAB10_ENST00000462003.1_3'UTR	NM_016131.4	NP_057215.3	P61026	RAB10_HUMAN	RAB10, member RAS oncogene family	175					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGCAGACCCCTGTAAAAGAG	0.413000													10	35					3.86212e-05	3.93362e-05	1	1	0
NEB	4703	broad.mit.edu	37	2	152536301	152536301	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:152536301T>C	ENST00000397345.3	-	32	3391	c.3189A>G	c.(3187-3189)ggA>ggG	p.G1063G	NEB_ENST00000409198.1_Silent_p.G1063G|NEB_ENST00000172853.10_Silent_p.G1063G|NEB_ENST00000427231.2_Silent_p.G1063G|NEB_ENST00000603639.1_Silent_p.G1063G|NEB_ENST00000604864.1_Silent_p.G1063G	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	1063					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCAGGTCATATCCCTTCTTGC	0.448000													29	95					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62036778	62036778	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:62036778T>C	ENST00000435607.1	-	12	1942	c.1866A>G	c.(1864-1866)acA>acG	p.T622T	SCN4A_ENST00000578147.1_Silent_p.T622T	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	622					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCATCTCTGCTGTGAAGATGC	0.582000													10	32					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2812213	2812213	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2812213T>C	ENST00000301740.8	+	11	2233	c.1684T>C	c.(1684-1686)Tcc>Ccc	p.S562P		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	562	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GCGAGGGAGGTCCCACTCTAG	0.622000													4	63					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40692915	40692915	+	Nonsense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:40692915A>T	ENST00000298910.7	+	25	3410	c.3352A>T	c.(3352-3354)Aaa>Taa	p.K1118*	LRRK2_ENST00000343742.2_Nonsense_Mutation_p.K1118*	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1118					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GACTAGAAATAAAATATCAGG	0.323000													19	79					0	0	1	0	0
PQLC2	54896	broad.mit.edu	37	1	19651169	19651169	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:19651169G>A	ENST00000375153.3	+	3	847	c.207G>A	c.(205-207)gcG>gcA	p.A69A	PQLC2_ENST00000375155.3_Silent_p.A69A|PQLC2_ENST00000400548.2_Silent_p.A4A	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	69	PQ-loop 1.					integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGGACCAGGCGCTGTCCCTGT	0.617000													24	90					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35280609	35280609	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:35280609T>C	ENST00000408931.3	-	5	1221	c.695A>G	c.(694-696)cAc>cGc	p.H232R		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	232						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						CTTAATGATGTGCACCCTTGG	0.373000													14	39					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53073971	53073971	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:53073971T>C	ENST00000276480.7	-	14	2241	c.1558A>G	c.(1558-1560)Aca>Gca	p.T520A		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	520						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCTTGCACTGTTTGTATGAGA	0.423000													27	154					0	0	1	0	0
GJD2	57369	broad.mit.edu	37	15	35045150	35045150	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:35045150C>T	ENST00000290374.4	-	2	971	c.495G>A	c.(493-495)gaG>gaA	p.E165E		NM_020660.2	NP_065711.1	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	165					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	19		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		AACAATCTGGCTCTGTCTCCT	0.507000													32	272					0	0	1	0	0
TRABD	80305	broad.mit.edu	37	22	50636360	50636360	+	Silent	SNP	C	C	T	rs139842330		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:50636360C>T	ENST00000303434.4	+	8	899	c.780C>T	c.(778-780)gaC>gaT	p.D260D	TRABD_ENST00000395827.1_Silent_p.D260D|TRABD_ENST00000395829.1_Silent_p.D260D|TRABD_ENST00000380909.4_Silent_p.D260D	NM_025204.2	NP_079480.2	Q9H4I3	TRABD_HUMAN	TraB domain containing	260										breast(1)|central_nervous_system(1)|large_intestine(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	7		all_cancers(38;1.07e-07)|all_epithelial(38;9.6e-07)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		LUAD - Lung adenocarcinoma(64;0.105)		CGGAGCGCGACGTCTACCTAA	0.667000													38	115					0	0	1	0	0
POU3F3	5455	broad.mit.edu	37	2	105473172	105473172	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:105473172G>T	ENST00000361360.2	+	1	1204	c.1204G>T	c.(1204-1206)Gcg>Tcg	p.A402S	RP11-13J10.1_ENST00000598623.1_RNA	NM_006236.1	NP_006227.1	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	402					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12						CAAGATCGCGGCGCAGGGCCG	0.632000													16	46					4.7546e-09	4.90914e-09	1	1	0
LRP1	4035	broad.mit.edu	37	12	57573223	57573223	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:57573223T>C	ENST00000243077.3	+	29	5316	c.4850T>C	c.(4849-4851)gTc>gCc	p.V1617A		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1617					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ATCGACAACGTCACAGTGCTA	0.582000													5	96					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208206837	208206837	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:208206837T>C	ENST00000367033.3	-	28	5639	c.4882A>G	c.(4882-4884)Acg>Gcg	p.T1628A		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1628					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GGGCTGCCCGTATACCTGAAG	0.602000													6	33					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50450322	50450322	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:50450322G>A	ENST00000331340.3	+	5	661	c.506G>A	c.(505-507)gGg>gAg	p.G169E	IKZF1_ENST00000359197.5_Missense_Mutation_p.G169E|IKZF1_ENST00000343574.5_Missense_Mutation_p.G82E|IKZF1_ENST00000438033.1_Missense_Mutation_p.G82E|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000439701.1_Missense_Mutation_p.G169E|IKZF1_ENST00000440768.2_Missense_Mutation_p.G169E|IKZF1_ENST00000349824.4_Intron|IKZF1_ENST00000357364.4_Missense_Mutation_p.G169E	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	169					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(131)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CTGCATTCCGGGGAGAAGCCC	0.642000			"""D,T"""	BCL6	"""ALL, DLBCL"""								6	14					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637817	158637817	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:158637817C>T	ENST00000368148.3	-	15	2049	c.1869G>A	c.(1867-1869)caG>caA	p.Q623Q	SPTA1_ENST00000368147.3_Silent_p.Q623Q	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	623					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAAAGACTTGCTGCTTTTGAA	0.393000													42	147					0	0	1	0	0
CD34	947	broad.mit.edu	37	1	208061250	208061250	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:208061250T>C	ENST00000310833.7	-	8	1312	c.991A>G	c.(991-993)Acg>Gcg	p.T331A	CD34_ENST00000485761.1_Intron|CD34_ENST00000367036.3_Missense_Mutation_p.T173A|CD34_ENST00000537704.1_Missense_Mutation_p.T196A|CD34_ENST00000356522.4_3'UTR	NM_001025109.1	NP_001020280.1	P28906	CD34_HUMAN	CD34 molecule	331					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						CCGTTTTCCGTGTAATAAGGG	0.552000													5	29					0	0	1	0	0
KLF1	10661	broad.mit.edu	37	19	12995742	12995742	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:12995742G>A	ENST00000264834.4	-	3	1086	c.1046C>T	c.(1045-1047)tCg>tTg	p.S349L		NM_006563.3	NP_006554.1	Q13351	KLF1_HUMAN	Kruppel-like factor 1 (erythroid)	349					erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|skin(1)	5		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCAGAGCGCGAAAAAGCACG	0.637000													36	69					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84203766	84203766	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84203766T>C	ENST00000378553.5	+	8	1456	c.1332T>C	c.(1330-1332)gcT>gcC	p.A444A	DNAAF1_ENST00000334315.5_Intron|DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	444	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						CCCTCCCAGCTGAGGCCCCAC	0.632000													11	97					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648984	130648984	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:130648984C>T	ENST00000229030.4	+	1	1981	c.1497C>T	c.(1495-1497)ccC>ccT	p.P499P	FZD10_ENST00000539839.1_3'UTR			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	499					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CCTCCATCCCCGCCGTGGAGA	0.557000													28	47					0	0	1	0	0
TNNT3	7140	broad.mit.edu	37	11	1957456	1957456	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1957456C>T	ENST00000360603.3	+	14	888	c.676C>T	c.(676-678)Cgg>Tgg	p.R226W	TNNT3_ENST00000278317.6_Intron|TNNT3_ENST00000381561.4_Intron|TNNT3_ENST00000381549.3_Intron|TNNT3_ENST00000381579.3_Missense_Mutation_p.R224W|TNNT3_ENST00000397301.1_Intron|TNNT3_ENST00000381589.3_Intron|TNNT3_ENST00000381548.3_Intron|TNNT3_ENST00000446240.1_Missense_Mutation_p.R213W|TNNT3_ENST00000381558.1_Intron|TNNT3_ENST00000397304.2_Intron			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	243					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		CATGAATGTCCGGGCCAGAGT	0.627000													21	58					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133878201	133878201	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:133878201G>A	ENST00000427044.2	-	15	1635	c.1025C>T	c.(1024-1026)aCg>aTg	p.T342M	RYK_ENST00000296084.4_Missense_Mutation_p.T532M			P34925	RYK_HUMAN	receptor-like tyrosine kinase	528	Protein kinase.				corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						TTCCCACAGCGTCACTCCAAA	0.537000													10	35					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19346377	19346377	+	Missense_Mutation	SNP	A	A	G	rs142943763	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:19346377A>G	ENST00000307015.9	+	19	2926	c.1174A>G	c.(1174-1176)Aca>Gca	p.T392A	DENND4C_ENST00000380432.2_Missense_Mutation_p.T919A|DENND4C_ENST00000602925.1_Missense_Mutation_p.T1155A|DENND4C_ENST00000434457.2_Missense_Mutation_p.T1204A|DENND4C_ENST00000540671.1_Missense_Mutation_p.T249A			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	919	dDENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						AACAGTAGATACATATGAGAG	0.408000													12	64					0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109479734	109479734	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109479734C>T	ENST00000369971.2	-	10	1477	c.1348G>A	c.(1348-1350)Gca>Aca	p.A450T	CLCC1_ENST00000369968.2_Missense_Mutation_p.A265T|CLCC1_ENST00000415331.1_Missense_Mutation_p.A400T|CLCC1_ENST00000369969.2_Missense_Mutation_p.A329T|CLCC1_ENST00000348264.2_Missense_Mutation_p.A265T|AKNAD1_ENST00000357393.4_Intron|CLCC1_ENST00000302500.4_Missense_Mutation_p.A329T|CLCC1_ENST00000369970.3_Missense_Mutation_p.A400T|CLCC1_ENST00000369976.1_Intron|CLCC1_ENST00000356970.2_Missense_Mutation_p.A450T|CLCC1_ENST00000482889.1_Intron	NM_001048210.1	NP_001041675.1	Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	450						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CGTGCCTCTGCGTCTGGTACA	0.483000													25	69					0	0	1	0	0
DCAF7	10238	broad.mit.edu	37	17	61628097	61628097	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:61628097A>G	ENST00000310827.4	+	1	276	c.59A>G	c.(58-60)tAc>tGc	p.Y20C	DCAF7_ENST00000577702.1_3'UTR|DCAF7_ENST00000415273.2_Missense_Mutation_p.Y20C|DCAF7_ENST00000431926.1_Missense_Mutation_p.Y20C	NM_005828.3	NP_005819.3	P61962	DCAF7_HUMAN	DDB1 and CUL4 associated factor 7	20					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	18						TGGACAGTCTACGCGATGAAC	0.637000													4	117					0	0	1	0	0
EIF3C	8663	broad.mit.edu	37	16	28734556	28734556	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:28734556A>G	ENST00000331666.6	+	9	1034	c.848A>G	c.(847-849)gAc>gGc	p.D283G	EIF3C_ENST00000566866.1_Missense_Mutation_p.D283G|EIF3C_ENST00000564243.1_Missense_Mutation_p.D273G|EIF3C_ENST00000395587.1_Missense_Mutation_p.D283G|EIF3C_ENST00000566501.1_Missense_Mutation_p.D283G			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	283						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(5)|skin(1)	6						AAGAAGCACGACAGGAAATCC	0.572000													12	626					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35548395	35548395	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35548395A>G	ENST00000455600.1	+	2	2446	c.1877A>G	c.(1876-1878)cAc>cGc	p.H626R		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	626						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CAGGGACCCCACTCCAGTGAG	0.647000													20	67					0	0	1	0	0
FAM211A	388341	broad.mit.edu	37	17	16365661	16365661	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:16365661A>G	ENST00000409083.3	-	2	448	c.286T>C	c.(286-288)Tat>Cat	p.Y96H	C17orf76-AS1_ENST00000579473.1_RNA|FAM211A_ENST00000470794.1_Missense_Mutation_p.Y96H|C17orf76-AS1_ENST00000478103.2_RNA|C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|C17orf76-AS1_ENST00000472367.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA	NM_207387.3	NP_997270.2	Q8NAA5	CQ076_HUMAN	family with sequence similarity 211, member A	96										lung(1)	1						GCGTAGCGATACAGAACGTCG	0.622000													17	49					0	0	1	0	0
CORO1B	57175	broad.mit.edu	37	11	67208934	67208934	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:67208934T>C	ENST00000393893.1	-	6	609	c.506A>G	c.(505-507)tAc>tGc	p.Y169C	CORO1B_ENST00000453768.2_Missense_Mutation_p.Y169C|CORO1B_ENST00000545016.1_3'UTR|CORO1B_ENST00000341356.5_Missense_Mutation_p.Y169C	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	169					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GTCCAGGCGGTACAGCTCCTC	0.607000													20	43					0	0	1	0	0
CMAS	55907	broad.mit.edu	37	12	22218161	22218161	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:22218161T>C	ENST00000229329.2	+	8	1351	c.1221T>C	c.(1219-1221)tgT>tgC	p.C407C		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	407					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						TTTGCAAATGTAATGGTGGCC	0.438000													45	156					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21751992	21751992	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:21751992C>T	ENST00000382254.1	-	15	3325	c.2239G>A	c.(2239-2241)Gtg>Atg	p.V747M	CDH12_ENST00000522262.1_Missense_Mutation_p.V707M|CDH12_ENST00000504376.2_Missense_Mutation_p.V747M|CDH12_ENST00000521384.1_5'UTR|RP11-804N13.1_ENST00000522350.1_RNA	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	747					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						GACTCTGCCACGGACCCACTC	0.512000										HNSCC(59;0.17)			14	104					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44111533	44111533	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:44111533G>A	ENST00000262419.6	-	11	3130	c.2660C>T	c.(2659-2661)aCg>aTg	p.T887M	KANSL1_ENST00000574590.1_Missense_Mutation_p.T887M|KANSL1_ENST00000575318.1_Missense_Mutation_p.T823M|KANSL1_ENST00000432791.1_Missense_Mutation_p.T887M|KANSL1_ENST00000393476.3_Missense_Mutation_p.T181M|KANSL1_ENST00000572904.1_Missense_Mutation_p.T887M	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	887						MLL1 complex	protein binding										CTACCTGGGCGTAAGGATTTC	0.463000													9	30					0	0	1	0	0
HIAT1	64645	broad.mit.edu	37	1	100527484	100527484	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:100527484A>G	ENST00000370152.3	+	5	601	c.465A>G	c.(463-465)gaA>gaG	p.E155E	RP4-714D9.2_ENST00000432294.1_RNA	NM_033055.2	NP_149044.2	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	155					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		AAGAGCATGAAAGAAGTATGG	0.358000													12	66					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240111605	240111605	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:240111605A>T	ENST00000345617.3	-	4	1054	c.263T>A	c.(262-264)aTc>aAc	p.I88N	HDAC4_ENST00000541256.1_Missense_Mutation_p.I57N	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	88					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AGCGATGAGGATCTGCCTCTG	0.667000													18	36					0	0	1	0	0
SIK2	23235	broad.mit.edu	37	11	111583056	111583056	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:111583056C>T	ENST00000304987.3	+	9	1396	c.1223C>T	c.(1222-1224)gCg>gTg	p.A408V		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	408					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						GGCTGTCAGGCGGAAGCTGCA	0.532000													10	59					0	0	1	0	0
RASGRP3	25780	broad.mit.edu	37	2	33745628	33745628	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:33745628T>C	ENST00000403687.3	+	6	985	c.245T>C	c.(244-246)aTt>aCt	p.I82T	RASGRP3_ENST00000402538.3_Missense_Mutation_p.I82T|RASGRP3_ENST00000407811.1_Missense_Mutation_p.I82T	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	82	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					AGGTACTGGATTCTGAAGTTT	0.383000													31	310					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89856547	89856547	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:89856547T>C	ENST00000287908.3	+	3	1148	c.755T>C	c.(754-756)aTa>aCa	p.I252T	STEAP2_ENST00000394621.2_Missense_Mutation_p.I252T|STEAP2_ENST00000394626.1_Missense_Mutation_p.I252T|STEAP2_ENST00000394632.1_Missense_Mutation_p.I252T|STEAP2_ENST00000394629.2_Missense_Mutation_p.I252T|STEAP2_ENST00000394622.2_Missense_Mutation_p.I252T|STEAP2_ENST00000402625.2_Missense_Mutation_p.I252T	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	252					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					AAAATTCCTATAGAGATTGTG	0.383000													15	70					0	0	1	0	0
BLVRB	645	broad.mit.edu	37	19	40953925	40953925	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40953925T>C	ENST00000263368.4	-	5	643	c.492A>G	c.(490-492)acA>acG	p.T164T	BLVRB_ENST00000595483.1_Silent_p.T121T	NM_000713.2	NP_000704.1	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase (NADPH))	164					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity			large_intestine(3)|lung(3)	6			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	CCAGGGTCACTGTGTACGCCC	0.552000													21	59					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887207	47887207	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:47887207A>T	ENST00000396105.1	-	3	1388	c.1142T>A	c.(1141-1143)gTc>gAc	p.V381D	ZNFX1_ENST00000371754.4_Missense_Mutation_p.V381D|ZNFX1_ENST00000371752.1_Missense_Mutation_p.V381D	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	381							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TAAAGGTCTGACGAAATCTTC	0.473000													31	87					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65490345	65490345	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:65490345C>T	ENST00000261883.4	-	9	2445	c.2279G>A	c.(2278-2280)cGg>cAg	p.R760Q		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	760					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CCTCTCACTCCGGTAGGCCCT	0.547000													61	161					0	0	1	0	0
STXBP3	6814	broad.mit.edu	37	1	109318958	109318958	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109318958A>G	ENST00000370008.3	+	8	647	c.597A>G	c.(595-597)aaA>aaG	p.K199K	STXBP3_ENST00000485167.1_3'UTR	NM_007269.2	NP_009200.2	O00186	STXB3_HUMAN	syntaxin binding protein 3	199	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TTTCTAGTAAACCTCTAGATA	0.279000													4	21					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105300	168105300	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:168105300A>G	ENST00000409195.1	+	9	7487	c.7398A>G	c.(7396-7398)gtA>gtG	p.V2466V	XIRP2_ENST00000409273.1_Silent_p.V2244V|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Silent_p.V2466V|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2291					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGAAAAAAGTAATGGTGATGA	0.368000													10	90					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98127953	98127953	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98127953A>G	ENST00000357947.3	-	21	3165	c.2940T>C	c.(2938-2940)ggT>ggC	p.G980G		NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	980	CUB 5.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TCAGGGAATCACCTGCAGAGT	0.478000													10	80					0	0	1	0	0
UTP14A	10813	broad.mit.edu	37	X	129059902	129059902	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:129059902A>G	ENST00000394422.3	+	13	1785	c.1757A>G	c.(1756-1758)gAa>gGa	p.E586G	RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000371042.3_Missense_Mutation_p.E418G|UTP14A_ENST00000425117.2_Missense_Mutation_p.E534G|UTP14A_ENST00000371051.5_Missense_Mutation_p.E532G	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	586					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						CAGGAAGATGAAGAGGAGAGA	0.483000											OREG0019920	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	6					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42950329	42950329	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:42950329C>T	ENST00000541208.1	+	3	448	c.79C>T	c.(79-81)Cga>Tga	p.R27*	ZNF662_ENST00000440367.2_Nonsense_Mutation_p.R27*|ZNF662_ENST00000328199.6_Nonsense_Mutation_p.R87*|KRBOX1_ENST00000426937.1_5'UTR|ZNF662_ENST00000422021.1_Nonsense_Mutation_p.R27*|ZNF662_ENST00000430067.2_3'UTR			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	27	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		CCAGCTGGAGCGAGGGGAAAC	0.577000													57	146					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021586	51021586	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:51021586C>T	ENST00000599957.1	-	3	1581	c.1384G>A	c.(1384-1386)Ggg>Agg	p.G462R	LRRC4B_ENST00000389201.3_Missense_Mutation_p.G462R			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	462	Gly-rich.					cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		ccggtgcccccggccgccacG	0.716000													15	35					0	0	1	0	0
DCAF15	90379	broad.mit.edu	37	19	14071164	14071164	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14071164T>C	ENST00000254337.6	+	11	1613	c.1592T>C	c.(1591-1593)gTc>gCc	p.V531A		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	531										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						TTCGAGACAGTCAGTGTAGGC	0.612000											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	88					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064610	78064610	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:78064610C>T	ENST00000299642.4	+	3	578	c.493C>T	c.(493-495)Cgt>Tgt	p.R165C	RP11-281J9.2_ENST00000563114.1_RNA|CLEC3A_ENST00000575655.1_Missense_Mutation_p.R156C|CLEC3A_ENST00000565808.1_3'UTR	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	156	C-type lectin.				skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						CAACTGGGACCGTGCACAGCC	0.532000													35	73					0	0	1	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17443617	17443617	+	RNA	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:17443617G>T	ENST00000458468.1	+	0	211					NR_027790.1																						GAAAGTATCTGGTTCAACCGC	0.537000													34	126					6.90743e-12	7.18621e-12	1	1	0
FLG	2312	broad.mit.edu	37	1	152283287	152283287	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152283287A>T	ENST00000368799.1	-	3	4110	c.4075T>A	c.(4075-4077)Tcc>Acc	p.S1359T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1359	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTGGCGGGATCCATGTCTT	0.547000									Ichthyosis				193	591					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113975727	113975727	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:113975727T>C	ENST00000332556.4	+	7	1079	c.885T>C	c.(883-885)agT>agC	p.S295S	LAMP1_ENST00000397181.3_Silent_p.S242S	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	295	Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AGAATGCAAGTTCTAGCCGGT	0.448000													22	62					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40433581	40433581	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:40433581A>T	ENST00000301825.3	+	3	226	c.108A>T	c.(106-108)gtA>gtT	p.V36V	ENTPD3_ENST00000445129.1_Silent_p.V36V|ENTPD3-AS1_ENST00000452768.1_RNA|ENTPD3-AS1_ENST00000425156.1_RNA|ENTPD3_ENST00000456402.1_Silent_p.V36V|ENTPD3-AS1_ENST00000439293.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	36						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GTATTGTGGTACTTGTGAGTA	0.498000													29	110					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62971474	62971474	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:62971474G>A	ENST00000251157.5	-	36	4496	c.4463C>T	c.(4462-4464)aCg>aTg	p.T1488M	DOCK7_ENST00000340370.5_Missense_Mutation_p.T1466M	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1497					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TTTGGATTCCGTTACAGAAAC	0.368000													15	46					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35257786	35257786	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:35257786C>T	ENST00000381318.3	+	38	5091	c.4803C>T	c.(4801-4803)aaC>aaT	p.N1601N	ITSN1_ENST00000437442.2_Silent_p.N1540N|ITSN1_ENST00000381285.4_Silent_p.N1601N|ITSN1_ENST00000399367.3_Silent_p.N1596N|ITSN1_ENST00000399326.3_3'UTR|AP000304.12_ENST00000429238.1_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1601	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						TGATGGTGAACGTGGTTGAAG	0.547000													32	98					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511746	130511746	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:130511746C>T	ENST00000314830.8	-	5	996	c.883G>A	c.(883-885)Gcc>Acc	p.A295T	SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Missense_Mutation_p.A138T|SH2D3C_ENST00000420366.1_Missense_Mutation_p.A137T|SH2D3C_ENST00000373276.3_Missense_Mutation_p.A227T|SH2D3C_ENST00000373274.3_Missense_Mutation_p.A135T|SH2D3C_ENST00000429553.1_5'UTR	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	295	SH2.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGCACGAGGGCGGGCACGTGG	0.587000													15	58					0	0	1	0	0
MAP6	4135	broad.mit.edu	37	11	75298324	75298324	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:75298324A>G	ENST00000304771.3	-	4	2972	c.2222T>C	c.(2221-2223)aTa>aCa	p.I741T	CTD-2530H12.4_ENST00000527803.1_RNA|MAP6_ENST00000526740.1_Missense_Mutation_p.I412T	NM_033063.1	NP_149052.1	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6	741	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	19	Ovarian(111;0.11)					TTCAGGGACTATACGACCTTG	0.512000													72	197					0	0	1	0	0
KRT12	3859	broad.mit.edu	37	17	39021207	39021207	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39021207T>C	ENST00000251643.4	-	3	681	c.658A>G	c.(658-660)Aat>Gat	p.N220D		NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	220	Coil 1B.|Rod.				visual perception	intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				GCCAGTTCATTCTCATACCTG	0.537000													6	94					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27472687	27472687	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27472687T>C	ENST00000356183.4	-	37	6329	c.6314A>G	c.(6313-6315)aAg>aGg	p.K2105R	GTF3C1_ENST00000561623.1_Missense_Mutation_p.K2080R	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	2105						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GTGGATCCACTTGTTCCAGTT	0.662000													18	75					0	0	1	0	0
WDR59	79726	broad.mit.edu	37	16	74985406	74985406	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:74985406G>A	ENST00000262144.6	-	4	406	c.276C>T	c.(274-276)gaC>gaT	p.D92D	WDR59_ENST00000562331.1_5'UTR	NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	92										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CCCCACTGCCGTCTTTCCACT	0.502000													4	10					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296500	39296500	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39296500G>A	ENST00000345847.4	-	1	239	c.240C>T	c.(238-240)tgC>tgT	p.C80C		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	76	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						AGCTAGGGCGGCAGCAGGTGG	0.657000													9	130					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853038	38853038	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:38853038G>A	ENST00000409235.3	+	19	2295	c.2180G>A	c.(2179-2181)aGc>aAc	p.S727N	AC005625.1_ENST00000590304.1_RNA|CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.S687N	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	727					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						TTCTTGGCGAGCAATTGGCGA	0.632000													6	194					0	0	1	0	0
DNAAF2	55172	broad.mit.edu	37	14	50092624	50092624	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:50092624A>G	ENST00000298292.8	-	3	2230	c.2150T>C	c.(2149-2151)cTa>cCa	p.L717P	DNAAF2_ENST00000406043.3_Missense_Mutation_p.L669P	NM_018139.2	NP_060609.2	Q9NVR5	KTU_HUMAN	dynein, axonemal, assembly factor 2	717					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm				kidney(1)|lung(4)	5						ATCTATTTGTAGTGCTTTAAC	0.333000													13	17					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35128968	35128968	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:35128968C>T	ENST00000373913.3	+	10	2937	c.2457C>T	c.(2455-2457)tgC>tgT	p.C819C	DLGAP4_ENST00000475894.1_3'UTR|DLGAP4_ENST00000340491.4_Silent_p.C283C|DLGAP4_ENST00000339266.5_Silent_p.C822C|DLGAP4_ENST00000401952.2_Silent_p.C819C|DLGAP4_ENST00000373907.2_Silent_p.C822C			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	822					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				AAGGCTGGTGCTGCCAGATGG	0.602000													29	95					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113534672	113534672	+	Silent	SNP	C	C	T	rs142267522	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:113534672C>T	ENST00000257600.3	+	9	2294	c.1791C>T	c.(1789-1791)gaC>gaT	p.D597D	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	597					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding	p.D597D(1)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						GCTACCCGGACGCTAGCTACC	0.637000													16	59					0	0	1	0	0
NPTN	27020	broad.mit.edu	37	15	73889513	73889513	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:73889513C>T	ENST00000345330.4	-	2	486	c.289G>A	c.(289-291)Ggc>Agc	p.G97S	NPTN_ENST00000562924.1_Intron|NPTN_ENST00000287226.8_Missense_Mutation_p.G97S|NPTN_ENST00000545878.1_Missense_Mutation_p.G97S|NPTN_ENST00000564551.1_Intron|NPTN_ENST00000542234.1_Intron|NPTN_ENST00000563691.1_Missense_Mutation_p.G97S|NPTN_ENST00000351217.6_Intron	NM_001161363.1|NM_012428.3	NP_001154835.1|NP_036560.1	Q9Y639	NPTN_HUMAN	neuroplastin	97	Ig-like 1.				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding	p.G97S(1)		breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						ACACTCACGCCGTTTGACCCG	0.582000													17	82					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58980561	58980561	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58980561T>C	ENST00000536459.2	+	2	718	c.9T>C	c.(7-9)ttT>ttC	p.F3F	ZNF324_ENST00000196482.3_Silent_p.F3F			O75467	Z324A_HUMAN	zinc finger protein 324	3	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGATGGCCTTTGAGGATGTGG	0.562000													4	106					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8722450	8722450	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:8722450T>C	ENST00000311434.9	-	19	2182	c.1943A>G	c.(1942-1944)aAc>aGc	p.N648S	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	649					platelet activation	cytosol											CTCTGTCACGTTGACATTCAG	0.532000													5	13					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41450647	41450647	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41450647C>T	ENST00000599198.1	+	0	1238					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						CTGAGCACTGCTCTCCGTGAC	0.478000													8	168					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50037668	50037668	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:50037668C>A	ENST00000261897.1	+	24	2916	c.2365C>A	c.(2365-2367)Cct>Act	p.P789T	FMNL3_ENST00000335154.5_3'UTR|PRPF40B_ENST00000548825.2_Missense_Mutation_p.P823T|PRPF40B_ENST00000380281.1_Missense_Mutation_p.P802T			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	802					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						TGAGACAGACCCTGAGGAGAA	0.527000													20	96					8.28177e-16	8.68412e-16	1	1	0
ABHD16B	140701	broad.mit.edu	37	20	62493327	62493327	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62493327T>A	ENST00000369916.3	+	1	762	c.434T>A	c.(433-435)cTg>cAg	p.L145Q		NM_080622.3	NP_542189.1	Q9H3Z7	ABHGB_HUMAN	abhydrolase domain containing 16B	145							hydrolase activity			endometrium(2)|kidney(1)|lung(3)	6						CGCGCCAAGCTGGTGGCCTGT	0.701000													16	61					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203186872	203186872	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:203186872T>C	ENST00000367229.1	-	10	1185	c.1151A>G	c.(1150-1152)gAa>gGa	p.E384G	CHIT1_ENST00000255427.3_Missense_Mutation_p.E365G|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Missense_Mutation_p.E375G	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	384					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						CTTACTCAGTTCCTGCCGTAG	0.592000													5	51					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670391	49670391	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:49670391C>T	ENST00000561648.1	-	4	2725	c.2672G>A	c.(2671-2673)tGt>tAt	p.C891Y	ZNF423_ENST00000563137.2_Missense_Mutation_p.C831Y|ZNF423_ENST00000567169.1_Missense_Mutation_p.C774Y|ZNF423_ENST00000562520.1_Missense_Mutation_p.C831Y|ZNF423_ENST00000535559.1_Missense_Mutation_p.C774Y|ZNF423_ENST00000262383.2_Missense_Mutation_p.C891Y|ZNF423_ENST00000562871.1_Missense_Mutation_p.C831Y	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	891					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GGCCGCCCCACAGATGTCACA	0.622000													30	99					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128848689	128848689	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:128848689C>G	ENST00000310343.9	-	18	2055	c.2056G>C	c.(2056-2058)Gag>Cag	p.E686Q	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.E337Q|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.E612Q|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.E337Q	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	686					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GCTTTCATCTCTGAAGGCTCA	0.478000													18	44					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26878180	26878180	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:26878180G>A	ENST00000374168.2	+	6	588	c.434G>A	c.(433-435)cGt>cAt	p.R145H	RPS6KA1_ENST00000374166.4_Missense_Mutation_p.R145H|RPS6KA1_ENST00000530003.1_Missense_Mutation_p.R129H|RPS6KA1_ENST00000531382.1_Missense_Mutation_p.R154H|RPS6KA1_ENST00000526792.1_Missense_Mutation_p.R53H|RPS6KA1_ENST00000374162.2_Missense_Mutation_p.R53H	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	145	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		GACTTCCTGCGTGGTGGGGAC	0.592000													24	71					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076249	57076249	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:57076249A>G	ENST00000532437.1	-	5	4247	c.3936T>C	c.(3934-3936)ggT>ggC	p.G1312G	TNKS1BP1_ENST00000358252.3_Silent_p.G1312G			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1312	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CCAGATTGTTACCCCAGTCCA	0.607000													25	317					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28887838	28887838	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:28887838A>T	ENST00000377199.3	-	3	1054	c.698T>A	c.(697-699)aTc>aAc	p.I233N	TRIM27_ENST00000377194.3_Missense_Mutation_p.I233N|TRIM27_ENST00000498117.1_5'UTR	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	233					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						TAGCTGAGCGATCAGGCTGCT	0.567000			T	RET	papillary thyroid								44	128					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12241954	12241954	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:12241954G>A	ENST00000256194.4	+	9	1443	c.1155G>A	c.(1153-1155)gaG>gaA	p.E385E	MICAL2_ENST00000527546.1_Silent_p.E385E|MICAL2_ENST00000342902.5_Silent_p.E385E|MICAL2_ENST00000537344.1_Silent_p.E385E|MICAL2_ENST00000379612.3_Silent_p.E385E	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	385						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		TGGTGCGGGAGCGGCAGGCGC	0.587000													31	79					0	0	1	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1330449	1330449	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:1330449G>A	ENST00000320895.5	-	9	1283	c.1026C>T	c.(1024-1026)gaC>gaT	p.D342D	CLPTM1L_ENST00000507807.1_Intron|CLPTM1L_ENST00000320927.6_Intron	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	342					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		TCGTCTGCTCGTCCAGCAGGA	0.647000													32	82					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77451921	77451921	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:77451921C>T	ENST00000308488.6	-	4	735	c.433G>A	c.(433-435)Gat>Aat	p.D145N	RSF1_ENST00000360355.2_Missense_Mutation_p.D114N			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	145					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			GTATCGGCATCCTCCTCATTA	0.378000													13	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498221	179498221	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179498221T>C	ENST00000589042.1	-	232	43089	c.42865A>G	c.(42865-42867)Aaa>Gaa	p.K14289E	TTN_ENST00000460472.2_Missense_Mutation_p.K5224E|TTN_ENST00000342992.6_Missense_Mutation_p.K11721E|TTN_ENST00000591111.1_Missense_Mutation_p.K12648E|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K5349E|TTN_ENST00000342175.6_Missense_Mutation_p.K5416E|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12648	Fibronectin type-III 3.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCGCCTTTTTGATTTTTAAG	0.433000													22	56					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629745	47629745	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:47629745G>A	ENST00000546455.1	+	4	1630	c.899G>A	c.(898-900)cGc>cAc	p.R300H	PCED1B_ENST00000432328.1_Missense_Mutation_p.R300H					PC-esterase domain containing 1B																		cccacataccgccccctgctt	0.637000													16	77					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61654293	61654293	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:61654293G>A	ENST00000397985.2	+	7	1162	c.906G>A	c.(904-906)atG>atA	p.M302I	SERPINB8_ENST00000353706.2_Missense_Mutation_p.M302I|SERPINB8_ENST00000542677.1_Missense_Mutation_p.M120I|SERPINB8_ENST00000493661.1_Intron	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	302					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				TTTCTGGAATGTCAACTGAGA	0.502000													16	59					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119575854	119575854	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:119575854C>T	ENST00000235521.4	-	6	789	c.763G>A	c.(763-765)Gtg>Atg	p.V255M	WARS2_ENST00000369426.5_3'UTR|WARS2_ENST00000537870.1_Missense_Mutation_p.V161M	NM_015836.3|NM_201263.2	NP_056651.1|NP_957715.1	Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	255					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	AAGTCTGTCACAGCCTTGCGG	0.582000													13	113					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43900072	43900072	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:43900072G>A	ENST00000562955.1	+	40	5649	c.5649G>A	c.(5647-5649)gaG>gaA	p.E1883E	SZT2_ENST00000372442.1_Silent_p.E1041E	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1940						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TGATTCGGGAGGATGGGGGGC	0.557000													4	9					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152722363	152722363	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:152722363A>C	ENST00000367255.5	-	47	7540	c.6939T>G	c.(6937-6939)atT>atG	p.I2313M	SYNE1_ENST00000423061.1_Missense_Mutation_p.I2320M|SYNE1_ENST00000448038.1_Missense_Mutation_p.I2320M|SYNE1_ENST00000265368.4_Missense_Mutation_p.I2313M|SYNE1_ENST00000341594.5_Missense_Mutation_p.I2350M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2313					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTATGTCATTAATAAACTTCT	0.378000										HNSCC(10;0.0054)			24	60					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41597687	41597687	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41597687A>G	ENST00000330436.3	+	5	705	c.705A>G	c.(703-705)caA>caG	p.Q235Q		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	235					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	GACCACAGCAACAGGCCTTTA	0.572000													4	89					0	0	1	0	0
TAS2R8	50836	broad.mit.edu	37	12	10959184	10959184	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:10959184C>T	ENST00000240615.2	-	1	708	c.396G>A	c.(394-396)tgG>tgA	p.W132*		NM_023918.1	NP_076407.1	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	132					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CCAGCAGGATCCAGTGCACCA	0.413000													17	72					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115102132	115102132	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:115102132G>A	ENST00000542447.2	-	4	631	c.503C>T	c.(502-504)gCt>gTt	p.A168V	CADM1_ENST00000331581.6_Missense_Mutation_p.A168V|CADM1_ENST00000537058.1_Missense_Mutation_p.A168V|CADM1_ENST00000536727.1_Missense_Mutation_p.A168V|CADM1_ENST00000537140.1_5'UTR|CADM1_ENST00000452722.2_Missense_Mutation_p.A168V	NM_001098517.1	NP_001091987.1	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	168	Ig-like C2-type 1.				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		GCTGGCCATAGCAGTGCAGTT	0.463000													30	76					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19751335	19751335	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19751335T>C	ENST00000203556.4	-	5	421	c.284A>G	c.(283-285)gAc>gGc	p.D95G	GMIP_ENST00000445806.2_Missense_Mutation_p.D95G|GMIP_ENST00000587238.1_Missense_Mutation_p.D95G	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	95					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAGGGCTGCGTCCACACCCCC	0.572000													31	77					0	0	1	0	0
EXT2	2132	broad.mit.edu	37	11	44129281	44129281	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:44129281T>C	ENST00000395673.3	+	2	174	c.118T>C	c.(118-120)Tat>Cat	p.Y40H	EXT2_ENST00000533608.1_Missense_Mutation_p.Y7H|EXT2_ENST00000358681.4_Missense_Mutation_p.Y7H|EXT2_ENST00000343631.3_Missense_Mutation_p.Y7H	NM_000401.3	NP_000392.3	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	7					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						GTCGGTCAAGTATAATATCCG	0.483000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				18	69					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900745	51900745	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:51900745G>A	ENST00000268919.4	+	1	507	c.351G>A	c.(349-351)gcG>gcA	p.A117A		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	117					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						AATGGGTTGCGATGATCCCCC	0.597000													48	118					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36210697	36210697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:36210697C>T	ENST00000420124.1	+	3	448	c.448C>T	c.(448-450)Cga>Tga	p.R150*	WBP7_ENST00000341701.1_Nonsense_Mutation_p.R150*|KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Nonsense_Mutation_p.R150*																							TCGAGCGCCCCGAGGTCGGGG	0.612000													39	145					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21521703	21521703	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21521703G>A	ENST00000222584.3	+	5	2287	c.2069G>A	c.(2068-2070)cGg>cAg	p.R690Q		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	690					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						AGATTCACACGGAGTGATGAG	0.363000													6	149					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	135988280	135988280	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:135988280T>C	ENST00000401392.1	-	13	1969	c.1757A>G	c.(1756-1758)cAc>cGc	p.H586R	ZRANB3_ENST00000264159.6_Missense_Mutation_p.H586R|ZRANB3_ENST00000412849.1_5'UTR|ZRANB3_ENST00000536680.1_Missense_Mutation_p.H586R			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	586						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		CGGACTGCAGTGGTCTTCCGA	0.493000													39	127					0	0	1	0	0
CASK	8573	broad.mit.edu	37	X	41390337	41390337	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:41390337T>G	ENST00000318588.9	-	25	2473	c.2428A>C	c.(2428-2430)Atg>Ctg	p.M810L	CASK_ENST00000361962.4_Missense_Mutation_p.M798L|CASK_ENST00000442742.2_Missense_Mutation_p.M787L|CASK_ENST00000378158.1_Missense_Mutation_p.M798L|CASK_ENST00000421587.2_Missense_Mutation_p.M786L|CASK_ENST00000378163.1_Missense_Mutation_p.M815L|CASK_ENST00000378166.4_Missense_Mutation_p.M810L			O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	815	Guanylate kinase-like.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|ovary(3)|prostate(1)|stomach(1)	32						GTCCCATACATCGCATCCTCG	0.483000													11	64					0	0	1	0	0
SLC35D1	23169	broad.mit.edu	37	1	67507985	67507985	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:67507985A>G	ENST00000235345.5	-	8	748	c.663T>C	c.(661-663)taT>taC	p.Y221Y	SLC35D1_ENST00000506472.2_Silent_p.Y142Y	NM_015139.2	NP_055954.1	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1	221					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	10					Lorazepam(DB00186)	GTGCATTGTAATAGAGCAGTC	0.413000													6	186					0	0	1	0	0
ACBD3	64746	broad.mit.edu	37	1	226340106	226340106	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:226340106C>G	ENST00000366812.5	-	7	1359	c.1305G>C	c.(1303-1305)tgG>tgC	p.W435C	RP11-275I14.4_ENST00000440540.1_RNA	NM_022735.3	NP_073572.2	Q9H3P7	GCP60_HUMAN	acyl-CoA binding domain containing 3	435	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding			breast(2)|endometrium(3)|large_intestine(5)|lung(7)|skin(1)|urinary_tract(2)	20	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		GAGAGTCTGTCCATTCAAAAT	0.473000													48	148					0	0	1	0	0
SS18L1	26039	broad.mit.edu	37	20	60749635	60749635	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:60749635G>A	ENST00000331758.3	+	10	1125	c.1099G>A	c.(1099-1101)Gga>Aga	p.G367R	SS18L1_ENST00000421564.1_Missense_Mutation_p.G367R|SS18L1_ENST00000370848.4_Missense_Mutation_p.G370R	NM_198935.1	NP_945173.1	O75177	CREST_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 1	367	Gln-rich.|Necessary for nuclear localization (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore			SS18L1/SSX1(2)	ovary(2)|skin(1)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			CCAGCAGTACGGAAGCTACCG	0.632000			T	SSX1	synovial sarcoma								56	189					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42793489	42793489	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:42793489G>A	ENST00000310232.6	-	5	625	c.542C>T	c.(541-543)gCc>gTc	p.A181V	CCDC13_ENST00000435327.2_5'UTR	NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	181										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						GGCCCCCTTGGCTGACAGCCT	0.572000													23	93					0	0	1	0	0
RPL6	6128	broad.mit.edu	37	12	112843724	112843724	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112843724T>C	ENST00000424576.2	-	6	832	c.647A>G	c.(646-648)tAc>tGc	p.Y216C	RPL6_ENST00000202773.9_Missense_Mutation_p.Y216C	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	216					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			cervix(1)|large_intestine(6)|lung(3)	10						CTTCTTGAAGTAAGCATCAGT	0.418000													31	51					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48736553	48736553	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:48736553A>G	ENST00000314191.2	-	65	8841	c.8785T>C	c.(8785-8787)Tat>Cat	p.Y2929H	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.Y2929H	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2930	FAT.|KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATTGATCTATACAGCCTACAA	0.358000								Non-homologous end-joining					6	60					0	0	1	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240672	26240672	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:26240672G>T	ENST00000377745.2	+	1	112	c.19G>T	c.(19-21)Ggt>Tgt	p.G7C		NM_003540.3	NP_003531.1	P62805	H4_HUMAN	histone cluster 1, H4f	7					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TAGAGGCAAAGGTGGTAAAGG	0.498000													5	52					1	1	1	1	0
KRT25	147183	broad.mit.edu	37	17	38907488	38907488	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:38907488T>C	ENST00000312150.4	-	4	820	c.760A>G	c.(760-762)Aac>Gac	p.N254D		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	254	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				GCTCGCATGTTGTTCAGCAGA	0.582000													21	64					0	0	1	0	0
EARS2	124454	broad.mit.edu	37	16	23546581	23546581	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:23546581G>A	ENST00000449606.1	-	4	617	c.586C>T	c.(586-588)Cca>Tca	p.P196S	EARS2_ENST00000564987.1_5'UTR|EARS2_ENST00000564501.1_Missense_Mutation_p.P196S|EARS2_ENST00000563459.1_Missense_Mutation_p.P196S|EARS2_ENST00000563232.1_Missense_Mutation_p.P196S	NM_001083614.1	NP_001077083.1	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2, mitochondrial	196					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	TGGAAGGCTGGCACCACCTGC	0.607000													5	79					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48467465	48467465	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48467465T>C	ENST00000435803.1	+	42	12586	c.12562T>C	c.(12562-12564)Tac>Cac	p.Y4188H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4188					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCTGTCTGGCTACTGTAAGTA	0.448000													5	25					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49772646	49772646	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:49772646A>G	ENST00000492622.2	+	23	3228	c.2923A>G	c.(2923-2925)Act>Gct	p.T975A	FNDC3A_ENST00000398316.3_Missense_Mutation_p.T919A|FNDC3A_ENST00000541916.1_Missense_Mutation_p.T975A	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	975	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GGGAGAAGGAACTCCAAAGAC	0.398000													23	102					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57037293	57037293	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:57037293C>T	ENST00000262030.3	-	5	736	c.686G>A	c.(685-687)gGt>gAt	p.G229D	ATP5B_ENST00000552919.1_Missense_Mutation_p.G229D	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	229					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CACAGAGTAACCACCATGGGC	0.433000													32	116					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23305363	23305363	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:23305363T>C	ENST00000358689.4	-	4	477	c.242A>G	c.(241-243)gAc>gGc	p.D81G	ENTPD4_ENST00000356206.6_Missense_Mutation_p.D81G|ENTPD4_ENST00000417069.2_Missense_Mutation_p.D81G	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	81					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		GTTATTGGTGTCTGTAGCTTC	0.443000													4	184					0	0	1	0	0
P2RX4	5025	broad.mit.edu	37	12	121659765	121659765	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:121659765A>G	ENST00000337233.4	+	3	640	c.332A>G	c.(331-333)cAg>cGg	p.Q111R	P2RX4_ENST00000543171.1_Missense_Mutation_p.Q10R|P2RX4_ENST00000541532.1_Missense_Mutation_p.Q111R|P2RX4_ENST00000540930.1_3'UTR|P2RX4_ENST00000359949.7_Missense_Mutation_p.Q127R	NM_001261397.1|NM_001261398.1|NM_002560.2	NP_001248326.1|NP_001248327.1|NP_002551.2	Q99571	P2RX4_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 4	111					endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding			breast(1)|kidney(4)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACCATGAACCAGACACAGGGC	0.657000													155	258					0	0	1	0	0
TBC1D31	93594	broad.mit.edu	37	8	124121584	124121584	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:124121584A>G	ENST00000287380.1	+	9	1327	c.1237A>G	c.(1237-1239)Aag>Gag	p.K413E	TBC1D31_ENST00000518805.1_Missense_Mutation_p.K46E|TBC1D31_ENST00000309336.3_Missense_Mutation_p.K413E|TBC1D31_ENST00000521676.1_Missense_Mutation_p.K308E|TBC1D31_ENST00000522420.1_Missense_Mutation_p.K308E|TBC1D31_ENST00000327098.5_Missense_Mutation_p.K413E|TBC1D31_ENST00000378080.2_Missense_Mutation_p.K308E	NM_145647.3	NP_663622.2			TBC1 domain family, member 31																		ATTAAACAAAAAGCGTTTACA	0.264000													4	76					0	0	1	0	0
TACR2	6865	broad.mit.edu	37	10	71164842	71164842	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:71164842T>C	ENST00000373306.4	-	5	1482		c.e5-2		TACR2_ENST00000373307.1_Splice_Site	NM_001057.2	NP_001048.2	P21452	NK2R_HUMAN	tachykinin receptor 2						excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	11					Clonidine(DB00575)|Octreotide(DB00104)	GAGCGAAACCTGGGGGAGCGA	0.617000													16	54					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98741199	98741199	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98741199G>A	ENST00000286067.2	+	1	159	c.52G>A	c.(52-54)Gag>Aag	p.E18K		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	18										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AATGGCAGCTGAGAATAGTGA	0.383000													15	66					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45540617	45540617	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45540617T>C	ENST00000291576.7	+	12	1570	c.1443T>C	c.(1441-1443)ttT>ttC	p.F481F		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	481						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		AGGACTCCTTTGAGATTTTCG	0.627000													9	101					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61815451	61815451	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:61815451G>T	ENST00000280772.1	-	42	13221	c.13030C>A	c.(13030-13032)Cat>Aat	p.H4344N	ANK3_ENST00000373827.2_Missense_Mutation_p.H1828N|ANK3_ENST00000503366.1_Missense_Mutation_p.H1835N|ANK3_ENST00000355288.2_Missense_Mutation_p.H968N	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4344					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TCTTCTTCATGGAGGCTAAGC	0.468000													81	252					1.72036e-36	1.82387e-36	1	1	0
GRXCR1	389207	broad.mit.edu	37	4	43032386	43032386	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:43032386G>A	ENST00000399770.2	+	4	702	c.702G>A	c.(700-702)caG>caA	p.Q234Q		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	234	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						AGAGAGTACAGCATCCACATG	0.493000													19	90					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55513547	55513547	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:55513547A>T	ENST00000474267.1	-	4	707	c.186T>A	c.(184-186)atT>atA	p.I62I	WNT5A_ENST00000264634.4_Silent_p.I62I|WNT5A_ENST00000497027.1_Silent_p.I47I			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	62					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		GTGCTCCTATAATATATACTT	0.488000													51	125					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30735661	30735661	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30735661G>A	ENST00000262518.4	+	25	5301	c.4916G>A	c.(4915-4917)gGa>gAa	p.G1639E	SRCAP_ENST00000395059.2_Missense_Mutation_p.G1577E|SRCAP_ENST00000344771.4_Missense_Mutation_p.G1481E	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1639	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCTACTCCAGGAACCTCTTTA	0.577000													39	134					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984194	41984194	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:41984194T>C	ENST00000333141.5	+	1	482	c.385T>C	c.(385-387)Tcc>Ccc	p.S129P		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	129										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						GAAGGTGAAGTCCCTGTGCTG	0.572000													44	129					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95993879	95993879	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:95993879A>G	ENST00000260766.3	+	6	2658	c.2024A>G	c.(2023-2025)aAg>aGg	p.K675R	PLCE1_ENST00000371375.1_Missense_Mutation_p.K367R|PLCE1_ENST00000371385.3_Missense_Mutation_p.K367R|PLCE1_ENST00000371380.2_Missense_Mutation_p.K675R	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	675	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AGGAGCCTGAAGGATGCTATG	0.468000													17	78					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122725654	122725654	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:122725654A>G	ENST00000306467.5	-	8	1523	c.1219T>C	c.(1219-1221)Tta>Cta	p.L407L	CEP120_ENST00000328236.5_Silent_p.L407L|CEP120_ENST00000306481.6_Silent_p.L381L			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	407						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TCATACTGTAAACTTTCCACT	0.388000													4	82					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2968215	2968215	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:2968215C>T	ENST00000342628.2	-	10	2108	c.1995G>A	c.(1993-1995)acG>acA	p.T665T	ITFG2_ENST00000545509.1_Intron|FOXM1_ENST00000361953.3_Silent_p.T612T|FOXM1_ENST00000359843.3_Silent_p.T627T	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	627					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TGGCTGGGGGCGTGAGCCTCC	0.592000													6	200					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16353263	16353263	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16353263C>A	ENST00000375692.1	+	8	776	c.648C>A	c.(646-648)ccC>ccA	p.P216P	CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000420078.1_Silent_p.P216P|CLCNKA_ENST00000331433.4_Silent_p.P216P|CLCNKA_ENST00000439316.2_Silent_p.P173P			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	216					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TTGCAGCTCCCTTCAGCGGTG	0.662000													28	78					5.45727e-16	5.72372e-16	1	1	0
TCHH	7062	broad.mit.edu	37	1	152083774	152083774	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152083774T>C	ENST00000368804.1	-	2	1918	c.1919A>G	c.(1918-1920)gAg>gGg	p.E640G		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	640	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGCCTCTCCTCCTGCTCCTC	0.672000													55	139					0	0	1	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54677727	54677727	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:54677727T>A	ENST00000546500.1	+	8	1498	c.883T>A	c.(883-885)Tac>Aac	p.Y295N	RP11-968A15.8_ENST00000553061.1_RNA|HNRNPA1_ENST00000547276.1_Missense_Mutation_p.Y242N|HNRNPA1_ENST00000330752.8_Missense_Mutation_p.Y282N|HNRNPA1_ENST00000340913.6_Missense_Mutation_p.Y347N			P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	347	Gly-rich.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20						TGGAGGCCAATACTTTGCAAA	0.428000													49	91					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870327	4870327	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:4870327G>A	ENST00000322101.2	-	1	187	c.112C>T	c.(112-114)Ccc>Tcc	p.P38S	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCAATGAGGGGCAATGTCCAC	0.582000													26	96					0	0	1	0	0
PNRC1	10957	broad.mit.edu	37	6	89793537	89793537	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:89793537T>C	ENST00000336032.3	+	2	723	c.606T>C	c.(604-606)ggT>ggC	p.G202G	PNRC1_ENST00000369472.1_Silent_p.G17G|PNRC1_ENST00000354922.3_Silent_p.G17G	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		TTGTTCATGGTATACACTTGT	0.348000										Multiple Myeloma(7;0.094)			10	42					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32640742	32640742	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:32640742A>C	ENST00000421745.2	+	10	2517	c.2383A>C	c.(2383-2385)Aat>Cat	p.N795H		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	795					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GAATGGTGCAAATATTAGTGT	0.363000													58	70					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994688	994688	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:994688C>A	ENST00000537687.1	+	19	6141	c.5498C>A	c.(5497-5499)cCa>cAa	p.P1833Q	WNK1_ENST00000530271.2_Missense_Mutation_p.P2071Q|WNK1_ENST00000340908.4_Missense_Mutation_p.P1166Q|WNK1_ENST00000535572.1_Missense_Mutation_p.P1326Q|WNK1_ENST00000315939.6_Missense_Mutation_p.P1573Q	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1573					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TTGGTCATTCCATCAGTGATA	0.493000													234	406					7.40589e-125	7.8644e-125	1	1	0
UGT2A1	10941	broad.mit.edu	37	4	70455168	70455168	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:70455168A>G	ENST00000503640.1	-	6	1561	c.1506T>C	c.(1504-1506)gcT>gcC	p.A502A	UGT2A1_ENST00000514019.1_Silent_p.A668A|UGT2A2_ENST00000457664.2_Silent_p.A511A|UGT2A1_ENST00000512704.1_Silent_p.A458A|UGT2A1_ENST00000286604.4_Silent_p.A502A	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	502					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						CCAAAAATATAGCCGTTGTCA	0.403000													4	91					0	0	1	0	0
TEX264	51368	broad.mit.edu	37	3	51708450	51708450	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:51708450C>T	ENST00000415259.1	+	2	1211	c.130C>T	c.(130-132)Cgc>Tgc	p.R44C	TEX264_ENST00000395057.1_Missense_Mutation_p.R44C|TEX264_ENST00000341333.5_Missense_Mutation_p.R44C|TEX264_ENST00000416589.1_Missense_Mutation_p.R44C|TEX264_ENST00000457573.1_Missense_Mutation_p.R44C			Q9Y6I9	TX264_HUMAN	testis expressed 264	44						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		ACCCCCCATCCGCAACGTCAC	0.607000													26	102					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75142422	75142422	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75142422A>G	ENST00000356357.4	-	8	1575	c.1060T>C	c.(1060-1062)Tac>Cac	p.Y354H	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		ACATAGCAGTACACCTTCTTC	0.507000													33	690					0	0	1	0	0
POGLUT1	56983	broad.mit.edu	37	3	119205681	119205681	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:119205681A>G	ENST00000295588.4	+	7	724	c.638_splice	c.e7-1	p.T214_splice		NM_152305.2	NP_689518.1	Q8NBL1	PGLT1_HUMAN	protein O-glucosyltransferase 1	214						endoplasmic reticulum lumen	UDP-glucosyltransferase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(1)	16						CTTTTATAGGACAAGTCCAGA	0.423000													4	221					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8720430	8720430	+	Missense_Mutation	SNP	A	A	G	rs115239581	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:8720430A>G	ENST00000359865.3	+	4	435	c.293A>G	c.(292-294)cAg>cGg	p.Q98R	SOGA2_ENST00000400050.3_Missense_Mutation_p.Q98R|SOGA2_ENST00000306329.11_Missense_Mutation_p.Q458R|SOGA2_ENST00000517570.1_Missense_Mutation_p.Q98R|SOGA2_ENST00000306285.7_5'UTR	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	449																	ACTCTCCGACAGCAGATGATT	0.488000													10	86					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246784753	246784753	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:246784753A>G	ENST00000366513.4	+	3	671	c.402A>G	c.(400-402)gcA>gcG	p.A134A	CNST_ENST00000366512.3_Silent_p.A134A|CNST_ENST00000483271.1_3'UTR	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	134					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GAGATATTGCACCTTTAATGC	0.373000													81	224					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144810789	144810789	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144810789G>A	ENST00000388913.3	-	5	967	c.842C>T	c.(841-843)tCc>tTc	p.S281F		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	281					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAGCGGCTCGGACTGCGCGAA	0.682000													10	45					0	0	1	0	0
AFG3L2	10939	broad.mit.edu	37	18	12340360	12340360	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:12340360T>C	ENST00000269143.3	-	15	2051	c.1820A>G	c.(1819-1821)cAg>cGg	p.Q607R		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	607					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	TGGTAAATACTGAGCATAACC	0.403000													12	134					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156513971	156513971	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156513971C>T	ENST00000361170.2	-	21	2443	c.2433G>A	c.(2431-2433)ctG>ctA	p.L811L		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	811	IQ 3.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCAGACGCCTCAGGTATTGCC	0.587000													56	136					0	0	1	0	0
TXNRD2	10587	broad.mit.edu	37	22	19864630	19864630	+	Nonstop_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:19864630A>G	ENST00000400519.1	-	17	1569	c.1570T>C	c.(1570-1572)Taa>Caa	p.*524Q	TXNRD2_ENST00000400518.1_Nonstop_Mutation_p.*495Q|TXNRD2_ENST00000400525.1_Nonstop_Mutation_p.*502Q|TXNRD2_ENST00000535882.1_3'UTR|TXNRD2_ENST00000542719.1_3'UTR|TXNRD2_ENST00000400521.1_Nonstop_Mutation_p.*525Q			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	0					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					GATGGCGCTTACCCTCAGCAG	0.662000													3	33					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64853808	64853808	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:64853808A>G	ENST00000328747.7	+	3	419	c.220A>G	c.(220-222)Acc>Gcc	p.T74A	ZNF92_ENST00000450302.2_Missense_Mutation_p.T5A|ZNF92_ENST00000357512.2_Intron|ZNF92_ENST00000431504.1_Intron	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	74	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				GGTAGACAAAACCCCAGGTAG	0.438000													5	132					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27221930	27221930	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27221930A>G	ENST00000286096.4	+	2	659	c.486A>G	c.(484-486)caA>caG	p.Q162Q	KDM8_ENST00000380948.2_Silent_p.Q162Q|KDM8_ENST00000441782.2_Silent_p.Q200Q|KDM8_ENST00000568965.1_Silent_p.Q162Q	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	162					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										TCCCAGAGCAACCCTGCACAA	0.582000													10	46					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52425582	52425582	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52425582A>G	ENST00000420323.2	+	63	10276	c.10015A>G	c.(10015-10017)Acc>Gcc	p.T3339A		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3404	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGAGATCTCCACCAAACTCAC	0.607000													21	49					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43322408	43322408	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43322408T>C	ENST00000331495.3	+	21	2997	c.2661T>C	c.(2659-2661)atT>atC	p.I887I	FMNL1_ENST00000328118.3_Silent_p.I887I|FMNL1_ENST00000587489.1_Silent_p.I465I	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	887	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						TGAAGGTCATTGCTGAGAAGT	0.577000													8	103					0	0	1	0	0
RBM4B	83759	broad.mit.edu	37	11	66436573	66436573	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66436573T>C	ENST00000525754.1	-	2	1270	c.602A>G	c.(601-603)tAc>tGc	p.Y201C	RBM4B_ENST00000524637.1_3'UTR|RBM4B_ENST00000310046.4_Missense_Mutation_p.Y201C|RBM4B_ENST00000531969.1_Intron			Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	201	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)|urinary_tract(2)	10						GCCCATGGTGTAAGGTGTTCG	0.502000													4	84					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19359503	19359503	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:19359503T>C	ENST00000261537.6	+	6	1029	c.765T>C	c.(763-765)gaT>gaC	p.D255D	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	255					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TAAATATAGATCTCGACCTCG	0.418000													4	196					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48026783	48026783	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:48026783G>A	ENST00000234420.4	+	4	1813	c.1661G>A	c.(1660-1662)cGt>cAt	p.R554H	MSH6_ENST00000538136.1_Missense_Mutation_p.R252H|FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Missense_Mutation_p.R424H	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	554					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGCCATACTCGTGCATATGGT	0.423000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				46	93					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153085393	153085393	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:153085393C>T	ENST00000285900.5	+	11	1932	c.1589C>T	c.(1588-1590)tCc>tTc	p.S530F	GRIA1_ENST00000521843.2_Missense_Mutation_p.S461F|GRIA1_ENST00000518783.1_Missense_Mutation_p.S540F|GRIA1_ENST00000448073.4_Missense_Mutation_p.S540F|GRIA1_ENST00000340592.5_Missense_Mutation_p.S530F|GRIA1_ENST00000518142.1_Missense_Mutation_p.S450F	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	530					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGTGTCTTCTCCTTCCTTGAT	0.438000													49	134					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100609603	100609603	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100609603G>C	ENST00000319509.7	+	8	2335	c.2335G>C	c.(2335-2337)Gcg>Ccg	p.A779P	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						CCACTGGAGGGCGCTGGTCGG	0.741000													3	14					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21478595	21478595	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:21478595G>A	ENST00000281523.2	-	5	1058	c.540C>T	c.(538-540)agC>agT	p.S180S	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	180	Thr-rich.					nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						CTGTCGTTGGGCTTTTTTCCA	0.473000													26	121					0	0	1	0	0
CIR1	9541	broad.mit.edu	37	2	175213789	175213789	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:175213789G>A	ENST00000342016.3	-	10	881	c.789C>T	c.(787-789)tcC>tcT	p.S263S	CIR1_ENST00000362053.5_3'UTR	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	263	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						aggaggaggaggaagatgagg	0.338000													4	14					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	91948721	91948721	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:91948721A>G	ENST00000265742.3	+	4	940	c.564A>G	c.(562-564)caA>caG	p.Q188Q		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	188							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGAAAAGCAACACCACAAAG	0.368000													3	75					0	0	1	0	0
MBNL3	55796	broad.mit.edu	37	X	131526279	131526279	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:131526279G>A	ENST00000538204.1	-	3	341	c.276C>T	c.(274-276)ctC>ctT	p.L92L	MBNL3_ENST00000370844.1_Silent_p.L46L|MBNL3_ENST00000394311.2_Silent_p.L46L|MBNL3_ENST00000370857.3_Silent_p.L142L|RP5-842K24.2_ENST00000421483.1_RNA|MBNL3_ENST00000473364.1_5'UTR|MBNL3_ENST00000370839.3_Silent_p.L142L|MBNL3_ENST00000370849.3_Silent_p.L92L|RP5-842K24.2_ENST00000441399.1_RNA|MBNL3_ENST00000370853.3_Silent_p.L142L	NM_001170702.1	NP_001164173.1	Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	142					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					CTGCAGGAACGAGGCCCATCC	0.463000													28	29					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105330708	105330708	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:105330708C>T	ENST00000369780.4	+	2	574	c.165C>T	c.(163-165)agC>agT	p.S55S	NEURL_ENST00000369777.2_Silent_p.S38S	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		55					nervous system development	perinuclear region of cytoplasm	zinc ion binding	p.S55S(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGCTGCCCAGCGGGGGGCTCC	0.652000													74	234					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531261	140531261	+	Missense_Mutation	SNP	G	G	A	rs17844436		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140531261G>A	ENST00000231136.1	+	1	1423	c.1423G>A	c.(1423-1425)Gac>Aac	p.D475N	PCDHB6_ENST00000543635.1_Missense_Mutation_p.D339N	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		475	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCGCCACAGACAGAGACTC	0.637000													30	333					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179044053	179044053	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:179044053G>A	ENST00000356731.5	-	9	2651	c.1117_splice	c.e9+1	p.Y372_splice	HNRNPH1_ENST00000511300.2_Silent_p.Y102Y|HNRNPH1_ENST00000510411.1_Silent_p.Y372Y|HNRNPH1_ENST00000442819.2_Splice_Site_p.Y372_splice|HNRNPH1_ENST00000393432.4_Splice_Site_p.Y372_splice|HNRNPH1_ENST00000329433.6_Splice_Site_p.Y372_splice			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	372	2 X 16 AA Gly-rich approximate repeats.|2 X 19 AA perfect repeats.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						TTTGGCTACCGTAAGCACCAC	0.373000													4	128					0	0	1	0	0
KCTD11	147040	broad.mit.edu	37	17	7256424	7256424	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7256424G>T	ENST00000333751.3	+	1	1217	c.163G>T	c.(163-165)Gcg>Tcg	p.A55S	RP11-542C16.1_ENST00000572417.1_RNA	NM_001002914.2	NP_001002914.1	Q693B1	KCD11_HUMAN	potassium channel tetramerization domain containing 11	55					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity			kidney(1)|large_intestine(2)|lung(1)	4		Prostate(122;0.157)				CGGAGAGACAGCGCTGCTCAG	0.667000													13	44					4.36969e-10	4.52622e-10	1	1	0
MGAM	8972	broad.mit.edu	37	7	141736759	141736759	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:141736759C>T	ENST00000475668.2	+	18	2267	c.2213C>T	c.(2212-2214)gCc>gTc	p.A738V	MGAM_ENST00000549489.2_Missense_Mutation_p.A738V			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	738	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GACACGGTGGCCAGGCCCCTT	0.443000													64	219					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47552155	47552155	+	Missense_Mutation	SNP	G	G	A	rs145381639		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47552155G>A	ENST00000300527.4	+	28	2853	c.2749G>A	c.(2749-2751)Gtg>Atg	p.V917M		NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	917	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CTTCTCGCACGTGGGCGCAGG	0.682000													6	10					0	0	1	0	0
TLX2	3196	broad.mit.edu	37	2	74742952	74742952	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:74742952A>G	ENST00000233638.7	+	2	916	c.593A>G	c.(592-594)gAc>gGc	p.D198G		NM_016170.4	NP_057254.1	O43763	TLX2_HUMAN	T-cell leukemia homeobox 2	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|ovary(1)	2						CGCATGACCGACGCACAGGTC	0.692000													10	39					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78362385	78362385	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:78362385T>C	ENST00000397909.2	+	5	747	c.574T>C	c.(574-576)Tac>Cac	p.Y192H	NAV3_ENST00000536525.2_Missense_Mutation_p.Y192H|NAV3_ENST00000228327.6_Missense_Mutation_p.Y192H|NAV3_ENST00000266692.7_Missense_Mutation_p.Y192H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	192						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAACAACAGTACTATCAGTC	0.448000										HNSCC(70;0.22)			6	85					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129494	149129494	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:149129494T>C	ENST00000247930.4	-	6	2192	c.1869A>G	c.(1867-1869)tcA>tcG	p.S623S		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	623					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CAGAGCTGGGTGACTTGGGAC	0.667000													9	271					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35920007	35920007	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35920007A>G	ENST00000325722.3	-	11	1970	c.1736T>C	c.(1735-1737)aTa>aCa	p.I579T	KIAA0319L_ENST00000373266.4_Missense_Mutation_p.I16T|KIAA0319L_ENST00000485551.1_5'UTR	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	579	PKD 3.					cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTGCTGTCCTATTGTGTCAGT	0.473000													20	63					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159410	18159410	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18159410A>G	ENST00000396275.2	+	3	1022	c.661A>G	c.(661-663)Aca>Gca	p.T221A		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	221						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CATCCTCCTCACAGTGCTGGT	0.552000													27	77					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156348	70156348	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:70156348G>A	ENST00000335568.5	+	5	1131	c.1129G>A	c.(1129-1131)Gcc>Acc	p.A377T	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	377					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	TCATGGTGGAGCCAATGGCAT	0.398000													7	180					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86305002	86305002	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:86305002T>C	ENST00000263857.6	-	11	1738	c.1360A>G	c.(1360-1362)Aac>Gac	p.N454D	POLR1A_ENST00000409681.1_Missense_Mutation_p.N454D			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	454					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						CCAATTTCGTTGGTGTTGATG	0.542000													44	130					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29527540	29527540	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:29527540C>T	ENST00000358273.4	+	9	1372	c.989C>T	c.(988-990)gCa>gTa	p.A330V	NF1_ENST00000356175.3_Missense_Mutation_p.A330V|NF1_ENST00000431387.4_Missense_Mutation_p.A330V	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	330					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTGTGTAAAGCAAGTACTTAC	0.413000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			20	74					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9972629	9972629	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:9972629T>C	ENST00000295981.3	+	16	1818		c.e16+2		IL17RC_ENST00000498214.1_Splice_Site|IL17RC_ENST00000383812.4_Splice_Site|IL17RC_ENST00000455057.1_Splice_Site|IL17RC_ENST00000416074.2_Splice_Site|IL17RC_ENST00000403601.3_Splice_Site|IL17RC_ENST00000413608.1_Splice_Site	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C							integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TGGACAAATGTGAGTATTGTA	0.522000													55	147					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116719879	116719879	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:116719879G>A	ENST00000375300.1	-	21	3637	c.3632C>T	c.(3631-3633)gCc>gTc	p.A1211V	SIK3_ENST00000488337.1_5'UTR|SIK3_ENST00000542607.1_Missense_Mutation_p.A1093V|SIK3_ENST00000375288.1_Missense_Mutation_p.A488V|SIK3_ENST00000446921.2_Missense_Mutation_p.A1151V|SIK3_ENST00000292055.4_Missense_Mutation_p.A1153V|SIK3_ENST00000434315.2_Missense_Mutation_p.A992V|AP006216.12_ENST00000444200.1_RNA			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	1153						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						TCTCTGGAGGGCCCGGGGCCT	0.597000													44	97					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073402	74073402	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:74073402G>A	ENST00000370367.3	+	3	526	c.473G>A	c.(472-474)cGt>cAt	p.R158H		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		GGGACCCAGCGTTCGGTGGAA	0.672000													31	70					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40065975	40065975	+	Splice_Site	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:40065975C>G	ENST00000373233.3	-	27	4185		c.e27-1		CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6						chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding	p.?(1)		breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TGTGTTGCCTCTAAATAAAAG	0.398000													16	40					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28880417	28880417	+	Splice_Site	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:28880417G>C	ENST00000337120.5	+	3	4423	c.1133_splice	c.e3+1	p.G378_splice	SH2B1_ENST00000545570.1_Splice_Site_p.G68_splice|SH2B1_ENST00000538342.1_Splice_Site_p.G42_splice|SH2B1_ENST00000359285.5_Splice_Site_p.G378_splice|SH2B1_ENST00000322610.8_Splice_Site_p.G378_splice|SH2B1_ENST00000395532.4_Splice_Site_p.G378_splice|SH2B1_ENST00000563674.1_Intron	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	378	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity	p.G378*(2)		endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						CCTGAGCCCAGGGTGAGAAGC	0.562000													6	120					0	0	1	0	0
HLA-F	3134	broad.mit.edu	37	6	29693278	29693278	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:29693278T>C	ENST00000440587.2	+	5	946	c.587T>C	c.(586-588)gTc>gCc	p.V196A	HLA-F_ENST00000376861.1_Missense_Mutation_p.V314A|HLA-F_ENST00000259951.7_Missense_Mutation_p.V314A|HLA-F_ENST00000334668.4_Missense_Mutation_p.V314A|HLA-F_ENST00000475996.1_3'UTR|HLA-F_ENST00000434407.2_Missense_Mutation_p.V222A			P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	314	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						GGCCTTGTTGTCCTTGGAGCT	0.587000													56	179					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618583	77618583	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:77618583G>A	ENST00000521891.2	+	2	2708	c.2260G>A	c.(2260-2262)Gga>Aga	p.G754R	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G754R|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G754R|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G754R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	754						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTGGCTGCGGAACACCCTC	0.527000										HNSCC(33;0.089)			20	36					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139077983	139077983	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:139077983T>C	ENST00000333188.5	-	19	2522	c.2341A>G	c.(2341-2343)Aat>Gat	p.N781D	COPB2_ENST00000507777.1_Missense_Mutation_p.N752D	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	781					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						GCTTTCTGATTGACTTTTGAG	0.398000													21	83					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7612634	7612634	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:7612634A>G	ENST00000340080.4	+	4	949	c.528A>G	c.(526-528)aaA>aaG	p.K176K	MIOS_ENST00000405785.1_Silent_p.K176K	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	176										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TAGTAACAAAACCACTTTATG	0.388000													13	40					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161519378	161519378	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:161519378C>T	ENST00000392142.4	+	17	3741	c.3593C>T	c.(3592-3594)gCt>gTt	p.A1198V	MAP3K4_ENST00000348824.7_Intron|MAP3K4_ENST00000366920.2_Missense_Mutation_p.A1194V|MAP3K4_ENST00000366919.2_Intron	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1198	Poly-Ala.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		gctgctgctgctgctgttgct	0.597000													83	210					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43687081	43687081	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:43687081T>C	ENST00000360835.3	-	4	581	c.455A>G	c.(454-456)aAc>aGc	p.N152S	SCUBE1_ENST00000290460.7_Missense_Mutation_p.N152S	NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	152	EGF-like 3; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GGTATGCTGGTTGTCACTAAG	0.582000													6	15					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176399	142176399	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:142176399C>T	ENST00000390369.2	-	0	276																											AGAGTGGAGACGGATCTCTCA	0.582000													21	68					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541364	55541364	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:55541364T>C	ENST00000361760.1	+	1	451	c.451T>C	c.(451-453)Tat>Cat	p.Y151H		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				GGCTGGGTCCTATACATGGGG	0.423000													63	163					0	0	1	0	0
KIAA1430	57587	broad.mit.edu	37	4	186111712	186111712	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:186111712A>G	ENST00000458385.2	-	2	758	c.639T>C	c.(637-639)ggT>ggC	p.G213G	KIAA1430_ENST00000514798.1_Silent_p.G213G|KIAA1430_ENST00000296775.6_Silent_p.G213G	NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430	213	Ser-rich.									endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		GGAGGGTTATACCAGATACAT	0.418000													6	33					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6703349	6703349	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:6703349G>A	ENST00000338694.2	-	8	1383	c.1254C>T	c.(1252-1254)tgC>tgT	p.C418C	TEKT1_ENST00000535086.1_Silent_p.C272C	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	418					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				CCTACTATTAGCAGACAGCAT	0.527000													43	137					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3210407	3210407	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:3210407T>C	ENST00000380059.3	-	14	1735	c.1634A>G	c.(1633-1635)tAc>tGc	p.Y545C	SLC4A11_ENST00000474451.1_Intron|SLC4A11_ENST00000380056.3_Missense_Mutation_p.Y518C|SLC4A11_ENST00000539553.1_Missense_Mutation_p.Y502C	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	518	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity	p.Y518C(1)|p.Y545C(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						ATGCCCATAGTAGTACTTCCA	0.597000													26	96					0	0	1	0	0
IRS2	8660	broad.mit.edu	37	13	110434506	110434506	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:110434506C>T	ENST00000375856.3	-	1	4409	c.3895G>A	c.(3895-3897)Gtc>Atc	p.V1299I		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1299					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			GTGCTGCCGACGCCCACAGCG	0.726000													11	18					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25365243	25365243	+	Silent	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25365243A>C	ENST00000330560.3	+	15	3538	c.3061A>C	c.(3061-3063)Aga>Cga	p.R1021R	CDCA2_ENST00000521098.2_3'UTR|CDCA2_ENST00000380665.3_Silent_p.R1006R	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1021					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TAATGGAGAAAGAAAGCAGTA	0.453000													26	114					0	0	1	0	0
SLC44A3	126969	broad.mit.edu	37	1	95322958	95322958	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:95322958G>C	ENST00000271227.6	+	10	1242	c.1140G>C	c.(1138-1140)tgG>tgC	p.W380C	SLC44A3_ENST00000529450.1_Missense_Mutation_p.W348C|SLC44A3_ENST00000446120.2_Missense_Mutation_p.W344C|SLC44A3_ENST00000532427.1_Missense_Mutation_p.W300C|SLC44A3_ENST00000527077.1_Missense_Mutation_p.W312C|SLC44A3_ENST00000467909.1_Missense_Mutation_p.W332C|SLC44A3_ENST00000530397.1_3'UTR	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	380						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	GGTACATGTGGTCGTACCATT	0.463000													32	68					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40630422	40630422	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:40630422G>A	ENST00000342449.3	-	18	2140	c.2062C>T	c.(2062-2064)Ccc>Tcc	p.P688S	BRWD1_ENST00000380800.3_Missense_Mutation_p.P688S|BRWD1_ENST00000333229.2_Missense_Mutation_p.P688S	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	688					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CCTCTCCGGGGTGTTTCTTCA	0.388000													58	161					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53586550	53586550	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:53586550A>G	ENST00000025008.5	-	7	1380	c.857T>C	c.(856-858)gTt>gCt	p.V286A	RB1CC1_ENST00000539297.1_Missense_Mutation_p.V286A|RB1CC1_ENST00000435644.2_Missense_Mutation_p.V286A|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	286					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TTGCTGATGAACAGTACTTTG	0.388000													55	172					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41146652	41146652	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:41146652A>G	ENST00000344051.4	+	7	1280	c.1046A>G	c.(1045-1047)gAc>gGc	p.D349G	SPINT1_ENST00000431806.1_Missense_Mutation_p.D333G|SPINT1_ENST00000562057.1_Missense_Mutation_p.D333G			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	349	LDL-receptor class A.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		TGCTGCATCGACAGTTTCCTG	0.612000													14	91					0	0	1	0	0
CPEB2	132864	broad.mit.edu	37	4	15054114	15054114	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:15054114A>G	ENST00000538197.1	+	7	2277	c.2277A>G	c.(2275-2277)tcA>tcG	p.S759S	CPEB2_ENST00000345451.3_Silent_p.S284S|CPEB2_ENST00000259997.5_Silent_p.S322S|CPEB2_ENST00000382395.3_Silent_p.S292S|CPEB2_ENST00000382401.3_Silent_p.S287S|CPEB2_ENST00000442003.2_Silent_p.S732S|CPEB2_ENST00000507071.1_Silent_p.S314S|RP11-665G4.1_ENST00000502344.1_RNA|CPEB2_ENST00000541112.1_Silent_p.S751S|RP11-665G4.1_ENST00000513384.1_RNA	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	314					regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						TTTTAAATTCACCCACCTGTT	0.393000													23	86					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45899945	45899945	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45899945C>T	ENST00000418234.2	-	4	648	c.570G>A	c.(568-570)gcG>gcA	p.A190A	PPP1R13L_ENST00000360957.5_Silent_p.A190A	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	190	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GGGGCCCCTCCGCCAGGGGGC	0.786000													4	11					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118198900	118198900	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:118198900A>G	ENST00000425217.1	-	4	869	c.815T>C	c.(814-816)tTg>tCg	p.L272S	KSR2_ENST00000339824.5_Missense_Mutation_p.L301S	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	301	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCCGGGATCAAGTGTATCAG	0.657000													29	362					0	0	1	0	0
CPSF7	79869	broad.mit.edu	37	11	61183875	61183875	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:61183875G>A	ENST00000340437.4	-	6	876	c.796C>T	c.(796-798)Ccc>Tcc	p.P266S	CPSF7_ENST00000394888.4_Missense_Mutation_p.P223S|CPSF7_ENST00000439958.3_Missense_Mutation_p.P214S|CPSF7_ENST00000448745.1_Missense_Mutation_p.P214S	NM_024811.3	NP_079087.3	Q8N684	CPSF7_HUMAN	cleavage and polyadenylation specific factor 7, 59kDa	223	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	22						TTGAAGTAGGGCAGCACACTG	0.592000													5	218					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3629072	3629072	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:3629072A>G	ENST00000325418.4	+	1	1862	c.1843A>G	c.(1843-1845)Atg>Gtg	p.M615V	ITGAE_ENST00000571185.1_Intron|ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	615	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										CTTAGAGCAAATGCGAACCAA	0.493000													9	141					0	0	1	0	0
ADI1	55256	broad.mit.edu	37	2	3502803	3502803	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:3502803C>T	ENST00000382093.5	-	4	3290	c.453G>A	c.(451-453)gcG>gcA	p.A151A	ADI1_ENST00000327435.6_Silent_p.A157A			Q9BV57	MTND_HUMAN	acireductone dioxygenase 1	157					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus|plasma membrane	acireductone dioxygenase (Ni2+-requiring) activity|metal ion binding|protein binding			breast(2)|large_intestine(2)|lung(4)|ovary(1)|stomach(1)	10	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0729)|Epithelial(75;0.173)|all cancers(51;0.228)		GCCGGTTGTACGCTGTCCACA	0.567000													19	50					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640329	99640329	+	Missense_Mutation	SNP	T	T	A	rs144139453	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:99640329T>A	ENST00000547776.2	-	13	2069	c.2070A>T	c.(2068-2070)agA>agT	p.R690S	ANKS1B_ENST00000550833.1_5'UTR|ANKS1B_ENST00000547010.1_Missense_Mutation_p.R270S|ANKS1B_ENST00000329257.7_Missense_Mutation_p.R690S	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	690						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TCCTGGTTGATCTTGTGCCAA	0.443000													13	52					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	599378	599378	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:599378C>T	ENST00000219611.2	+	6	2112	c.1749C>T	c.(1747-1749)taC>taT	p.Y583Y	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		AGGGCGCCTACCAGGTGCGGC	0.697000													6	14					0	0	1	0	0
SLC39A5	283375	broad.mit.edu	37	12	56629464	56629464	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56629464C>T	ENST00000266980.4	+	6	1218	c.925C>T	c.(925-927)Cgg>Tgg	p.R309W	SLC39A5_ENST00000454355.2_Missense_Mutation_p.R309W	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	309					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity	p.R308W(1)		NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGGGCTTTTGCGGCACCGAGG	0.632000													5	421					0	0	1	0	0
PDLIM3	27295	broad.mit.edu	37	4	186423556	186423556	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:186423556T>C	ENST00000284770.5	-	8	1060	c.987A>G	c.(985-987)caA>caG	p.Q329Q	PDLIM3_ENST00000284767.5_3'UTR|PDLIM3_ENST00000284771.6_Silent_p.Q281Q	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	329	LIM zinc-binding.					sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		AGTAGCCCTTTTGCTTGAGGT	0.567000													46	133					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5219973	5219973	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:5219973C>A	ENST00000372412.4	-	22	3978	c.3745G>T	c.(3745-3747)Gcc>Tcc	p.A1249S	PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Missense_Mutation_p.A817S|PTPRS_ENST00000588012.1_Missense_Mutation_p.A1226S|PTPRS_ENST00000357368.4_Missense_Mutation_p.A1248S|PTPRS_ENST00000587303.1_Missense_Mutation_p.A1248S|PTPRS_ENST00000348075.2_Missense_Mutation_p.A1226S|PTPRS_ENST00000262963.6_Missense_Mutation_p.A1244S|PTPRS_ENST00000592099.1_Missense_Mutation_p.A817S			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1248					cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TGAAGCACGGCAAGCACGAAG	0.622000													6	270					0.00198382	0.00200201	1	1	0
SIPA1	6494	broad.mit.edu	37	11	65413733	65413733	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65413733C>T	ENST00000394224.3	+	7	1601	c.1305C>T	c.(1303-1305)atC>atT	p.I435I	SIPA1_ENST00000527525.1_Silent_p.I435I|SIPA1_ENST00000394227.3_Silent_p.I435I|SIPA1_ENST00000534313.1_Silent_p.I435I	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	435	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						TTGTGACCATCGTGTTCCAGG	0.612000													47	159					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4317368	4317368	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:4317368C>T	ENST00000337872.4	+	6	1503	c.1382C>T	c.(1381-1383)gCa>gTa	p.A461V	ZBTB49_ENST00000538529.1_5'UTR|ZBTB49_ENST00000355834.3_Intron	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						TCTAGGTTTGCAGCCTCTGGC	0.438000													7	16					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30887920	30887920	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:30887920C>T	ENST00000392772.2	-	10	927	c.650G>A	c.(649-651)tGc>tAc	p.C217Y	RP4-539M6.14_ENST00000442126.1_RNA|SEC14L4_ENST00000540456.1_Missense_Mutation_p.C256Y|SEC14L4_ENST00000381982.3_Missense_Mutation_p.C271Y|SEC14L4_ENST00000255858.7_Missense_Mutation_p.C271Y			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	271	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	CACCTGCTCGCACAGGTAGTA	0.617000													6	28					0	0	1	0	0
CLC	1178	broad.mit.edu	37	19	40225074	40225074	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40225074A>T	ENST00000221804.4	-	3	227	c.152T>A	c.(151-153)gTc>gAc	p.V51D		NM_001828.5	NP_001819.2	Q05315	LPPL_HUMAN	Charcot-Leyden crystal galectin	51	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)|stomach(1)	12	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		GAAATGGAAGACAATGTCTGA	0.502000													47	169					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237074	140237074	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140237074G>A	ENST00000307360.5	+	1	1441	c.1441G>A	c.(1441-1443)Gcg>Acg	p.A481T	PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.A481T|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1												p.A481S(2)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGTGGGACGCGGACGCGCA	0.662000													48	201					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940741	144940741	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144940741C>T	ENST00000525985.1	-	2	6752	c.6681G>A	c.(6679-6681)gcG>gcA	p.A2227A				P58107	EPIPL_HUMAN	epiplakin 1	2227						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAGGACGCCCGCGATGCAGC	0.677000													5	203					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449854	35449854	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:35449854T>C	ENST00000404801.1	-	4	1291	c.905A>G	c.(904-906)aAa>aGa	p.K302R	ZNF792_ENST00000605484.1_Missense_Mutation_p.K235R	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ATTGTGAACTTTCTGGTGTTG	0.468000													4	39					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49207285	49207285	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:49207285C>A	ENST00000340334.7	-	7	1085	c.717G>T	c.(715-717)caG>caT	p.Q239H	FOLH1_ENST00000343844.4_Intron|FOLH1_ENST00000533034.1_Missense_Mutation_p.Q239H|FOLH1_ENST00000356696.3_Missense_Mutation_p.Q254H|FOLH1_ENST00000256999.2_Missense_Mutation_p.Q254H	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	254					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TATTTCCACGCTGGACACCAC	0.483000													16	59					4.96729e-08	5.11586e-08	1	1	0
SLC5A9	200010	broad.mit.edu	37	1	48694628	48694628	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:48694628T>C	ENST00000236495.5	+	3	389		c.e3+2		SLC5A9_ENST00000438567.2_Splice_Site|SLC5A9_ENST00000420136.2_Splice_Site|SLC5A9_ENST00000533824.1_Splice_Site|RP5-1024N4.4_ENST00000606809.1_RNA	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9							integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						GAGTGGAACGTAAGGAAGCTG	0.582000													26	76					0	0	1	0	0
HERPUD2	64224	broad.mit.edu	37	7	35709871	35709871	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:35709871C>T	ENST00000396081.1	-	3	1097	c.293G>A	c.(292-294)aGc>aAc	p.S98N	HERPUD2_ENST00000311350.3_Missense_Mutation_p.S98N	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	98	Ser-rich.				response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						TCTATTGGTGCTGGATTTTGG	0.383000													19	70					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108315570	108315570	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:108315570C>A	ENST00000520734.1	-	4	519	c.234G>T	c.(232-234)gaG>gaT	p.E78D	ANGPT1_ENST00000520052.1_Missense_Mutation_p.E77D|ANGPT1_ENST00000518386.1_Intron			Q15389	ANGP1_HUMAN	angiopoietin 1	278					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GTTTCTCTTCCTCTCTTTTTC	0.313000													23	89					1.10923e-09	1.14765e-09	1	1	0
PCDHB13	56123	broad.mit.edu	37	5	140595076	140595076	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140595076C>T	ENST00000341948.4	+	1	1568	c.1381C>T	c.(1381-1383)Cgc>Tgc	p.R461C		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		461	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGTTCGTCCGCGAGAACAA	0.602000													6	359					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495265	30495265	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30495265C>T	ENST00000356798.6	+	8	1020	c.840C>T	c.(838-840)atC>atT	p.I280I	RP11-297C4.2_ENST00000569459.1_RNA|ITGAL_ENST00000454514.2_3'UTR|ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Silent_p.I197I	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	280	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	AAGACATCATCCGCTACATCA	0.582000													84	215					0	0	1	0	0
SGCE	8910	broad.mit.edu	37	7	94252690	94252690	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:94252690C>T	ENST00000415788.2	-	5	605	c.518G>A	c.(517-519)cGc>cAc	p.R173H	SGCE_ENST00000265735.7_Missense_Mutation_p.R137H|SGCE_ENST00000445866.2_Missense_Mutation_p.R137H|SGCE_ENST00000428696.2_Missense_Mutation_p.R137H|SGCE_ENST00000437425.2_Missense_Mutation_p.R96H|SGCE_ENST00000447873.1_Missense_Mutation_p.R137H			O43556	SGCE_HUMAN	sarcoglycan, epsilon	137					cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	14	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CTCAAAGGTGCGCCTGTTGTA	0.274000													9	34					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140869557	140869557	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140869557A>G	ENST00000252087.1	+	1	750	c.750A>G	c.(748-750)ggA>ggG	p.G250G	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		250	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACGTGTGGGAATCCCAGAGA	0.547000													6	304					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248570264	248570264	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248570264C>T	ENST00000366474.1	+	1	969	c.969C>T	c.(967-969)gtC>gtT	p.V323V		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	323					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGACAAAGTCCTCTCTGTGT	0.522000													37	132					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30108090	30108090	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:30108090C>T	ENST00000331968.5	-	5	946	c.717G>A	c.(715-717)tcG>tcA	p.S239S	PRKD1_ENST00000415220.2_Silent_p.S247S|PRKD1_ENST00000551644.1_5'UTR	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	239					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GACCAATAAACGACTCTGATG	0.338000													16	51					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1579861	1579861	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1579861G>T	ENST00000572621.1	-	15	2591	c.2326C>A	c.(2326-2328)Ctg>Atg	p.L776M	PRPF8_ENST00000304992.6_Missense_Mutation_p.L776M			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	776						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AGGCGGCCCAGATTCTTTTTA	0.592000													6	450					0.217242	0.217435	1	1	0
PRSS22	64063	broad.mit.edu	37	16	2906204	2906204	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2906204C>T	ENST00000161006.3	-	3	225	c.160G>A	c.(160-162)Gag>Aag	p.E54K	PRSS22_ENST00000574768.1_5'UTR|PRSS22_ENST00000571228.1_Missense_Mutation_p.E54K	NM_022119.3	NP_071402.1	Q9GZN4	BSSP4_HUMAN	protease, serine, 22	54	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|skin(2)	10						GTGCTGTCCTCGCCGCCCACA	0.607000													19	68					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100074394	100074394	+	Splice_Site	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:100074394G>T	ENST00000375202.2	+	18	1744		c.e18-1		RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_Splice_Site|CCDC180_ENST00000357054.1_Splice_Site|CCDC180_ENST00000411667.2_Splice_Site|CCDC180_ENST00000460482.2_Splice_Site|CCDC180_ENST00000529487.1_Splice_Site					coiled-coil domain containing 180																		TTGTGTCTCAGGGAAAAGGAA	0.552000													14	169					7.93312e-07	8.13695e-07	1	1	0
CCDC37	348807	broad.mit.edu	37	3	126138545	126138545	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:126138545T>C	ENST00000393425.1	+	9	899	c.800T>C	c.(799-801)cTg>cCg	p.L267P	CCDC37_ENST00000505024.1_Missense_Mutation_p.L267P|CCDC37_ENST00000352312.1_Missense_Mutation_p.L266P			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	266										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		CTATACAAGCTGTCGCCCAAG	0.493000													4	110					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41976694	41976694	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:41976694G>A	ENST00000372584.1	-	8	7660	c.6646C>T	c.(6646-6648)Ccc>Tcc	p.P2216S	HIVEP3_ENST00000372583.1_Missense_Mutation_p.P2217S|HIVEP3_ENST00000429157.2_Missense_Mutation_p.P2216S|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P2217S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	2217					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCTGCGGTGGGCCCTGGCAGC	0.706000													37	82					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31937436	31937436	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31937436G>A	ENST00000375394.2	+	28	3798	c.3685G>A	c.(3685-3687)Gcg>Acg	p.A1229T	SKIV2L_ENST00000544581.1_Missense_Mutation_p.A1036T	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	1229						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GATGGAGACAGCGGCTACCTT	0.582000													8	115					0	0	1	0	0
COMMD2	51122	broad.mit.edu	37	3	149470050	149470050	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:149470050G>A	ENST00000473414.1	-	2	146	c.92C>T	c.(91-93)gCt>gTt	p.A31V		NM_016094.3	NP_057178.2	Q86X83	COMD2_HUMAN	COMM domain containing 2	31							protein binding			NS(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GAATTCCACAGCAATCCGCCC	0.602000													9	168					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97490844	97490844	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:97490844C>T	ENST00000305510.3	+	2	1303	c.1275C>T	c.(1273-1275)ggC>ggT	p.G425G	CNNM3_ENST00000377060.3_Intron|ANKRD23_ENST00000476975.1_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	425	CBS 2.				ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						AGGGTGAAGGCGACCCCTTCT	0.607000													14	51					0	0	1	0	0
LONRF1	91694	broad.mit.edu	37	8	12595535	12595535	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:12595535G>A	ENST00000398246.3	-	4	1151	c.1082C>T	c.(1081-1083)tCt>tTt	p.S361F	LONRF1_ENST00000533751.1_Missense_Mutation_p.S4F	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	361					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		GAGAGACTGAGACTCTTCCAT	0.398000													28	92					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	25004699	25004699	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:25004699A>G	ENST00000533227.1	+	9	654	c.367A>G	c.(367-369)Act>Gct	p.T123A	LUZP2_ENST00000336930.6_Missense_Mutation_p.T209A	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	209						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AATGAAAGAGACTGTGCAGCT	0.418000													29	98					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11049553	11049553	+	RNA	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:11049553T>G	ENST00000470054.1	-	0	555									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGACCACAAGTAGTACAAAAG	0.448000													6	179					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39914749	39914749	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39914749T>C	ENST00000393931.3	-	10	1793	c.1675A>G	c.(1675-1677)Att>Gtt	p.I559V	JUP_ENST00000540235.1_Intron|JUP_ENST00000393930.1_Missense_Mutation_p.I559V|JUP_ENST00000310706.5_Missense_Mutation_p.I559V	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	559					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CCCTCCACAATCTCCTCCATC	0.602000													14	42					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2749790	2749790	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:2749790C>T	ENST00000382611.6	-	2	609	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	IRX2_ENST00000302057.5_Missense_Mutation_p.A121T|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	121						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		TCCCGCGTGGCGTTCTTGCGG	0.662000													28	75					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238274458	238274458	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:238274458C>T	ENST00000295550.4	-	12	6173	c.5721G>A	c.(5719-5721)caG>caA	p.Q1907Q	COL6A3_ENST00000472056.1_Silent_p.Q1300Q|COL6A3_ENST00000353578.4_Silent_p.Q1701Q|COL6A3_ENST00000346358.4_Silent_p.Q1707Q|COL6A3_ENST00000409809.1_Silent_p.Q1701Q|COL6A3_ENST00000347401.3_Silent_p.Q1706Q	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1907	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCATCTCTGGCTGGTACTCGT	0.627000													36	120					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97084908	97084908	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:97084908T>C	ENST00000524981.3	+	11	1437	c.1437T>C	c.(1435-1437)ggT>ggC	p.G479G				Q6ZTY8	CL063_HUMAN		453										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						ATTTTCAGGGTTTGCTTAGAA	0.323000													9	44					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36050968	36050968	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:36050968C>T	ENST00000262623.3	-	7	823	c.795G>A	c.(793-795)gtG>gtA	p.V265V		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	265			V -> A (in dbSNP:rs2733743).		ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CCAGGCCCTGCACGGTGCCTG	0.657000													24	58					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92430262	92430262	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:92430262G>A	ENST00000370389.2	+	3	976	c.52G>A	c.(52-54)Gct>Act	p.A18T	BRDT_ENST00000362005.3_Missense_Mutation_p.A91T|BRDT_ENST00000402388.1_Missense_Mutation_p.A91T|BRDT_ENST00000394530.3_Intron|BRDT_ENST00000399546.2_Missense_Mutation_p.A91T	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		TTATGCGAAGGCTTCAGAATG	0.279000													13	26					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46950805	46950805	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:46950805C>T	ENST00000311124.4	-	4	1182	c.1030G>A	c.(1030-1032)Gcc>Acc	p.A344T	SLC19A1_ENST00000567670.1_Missense_Mutation_p.A344T|SLC19A1_ENST00000485649.2_Missense_Mutation_p.A304T|SLC19A1_ENST00000380010.4_Missense_Mutation_p.A344T	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	344					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GCCTGCGTGGCCGTGACGCCC	0.692000													3	14					0	0	1	0	0
NSRP1	84081	broad.mit.edu	37	17	28445178	28445178	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:28445178A>G	ENST00000247026.5	+	2	164	c.101A>G	c.(100-102)gAt>gGt	p.D34G	NSRP1_ENST00000479218.2_3'UTR|NSRP1_ENST00000540900.3_Intron|NSRP1_ENST00000584423.1_Missense_Mutation_p.D34G	NM_001261467.1|NM_032141.3	NP_001248396.1|NP_115517.1	Q9H0G5	NSRP1_HUMAN	nuclear speckle splicing regulatory protein 1	34	Poly-Asp.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	14						AATGATTCTGATGATGATGAT	0.353000													35	114					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216462747	216462747	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:216462747T>C	ENST00000366943.2	-	11	2232	c.1846A>G	c.(1846-1848)Aac>Gac	p.N616D	USH2A_ENST00000307340.3_Missense_Mutation_p.N616D|USH2A_ENST00000366942.3_Missense_Mutation_p.N616D			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	616	Laminin EGF-like 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCTCACAGTTCCTTCCTGCA	0.403000										HNSCC(13;0.011)			7	90					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58475270	58475270	+	Missense_Mutation	SNP	A	A	G	rs148122576		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:58475270A>G	ENST00000357552.3	-	18	1552	c.1327T>C	c.(1327-1329)Tcc>Ccc	p.S443P	SYCP2_ENST00000371001.2_Missense_Mutation_p.S443P			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	443					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCCTTTGGGGACTTTGATTTT	0.338000													14	51					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	71					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587708	43587708	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43587708A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							AACAACCACCATCTCCAAATC	0.348000													4	106					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5920253	5920253	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:5920253T>C	ENST00000399933.3	-	8	5742	c.5743A>G	c.(5743-5745)Act>Gct	p.T1915A	KIAA2026_ENST00000381461.2_Missense_Mutation_p.T1885A	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1915										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTGGATTAGTAGATATAAGG	0.438000													10	237					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94975823	94975823	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:94975823C>T	ENST00000261226.4	-	2	701	c.570G>A	c.(568-570)ggG>ggA	p.G190G	TMCC3_ENST00000551457.1_Silent_p.G159G	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	190						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						TAAGTGAGACCCCTGGCATGC	0.498000													43	158					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11304261	11304261	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11304261T>C	ENST00000432929.2	-	4	855	c.495A>G	c.(493-495)ccA>ccG	p.P165P	KANK2_ENST00000586659.1_Silent_p.P165P|KANK2_ENST00000589894.1_Silent_p.P165P|KANK2_ENST00000355150.5_Silent_p.P165P|KANK2_ENST00000589359.1_Silent_p.P165P	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	165										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GTGTCGGGGGTGGCAACCCCA	0.736000													12	22					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23932595	23932595	+	Translation_Start_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:23932595G>A	ENST00000402364.1	-	0	566				SACS_ENST00000382298.3_Silent_p.N161N|SACS_ENST00000382292.3_Silent_p.N161N	NM_001278055.1	NP_001264984.1	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)						cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding	p.N14N(1)|p.N161N(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGAAAACCGCGTTGTTGTACA	0.458000													32	140					0	0	1	0	0
SLC35G1	159371	broad.mit.edu	37	10	95658362	95658362	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:95658362C>T	ENST00000371408.3	+	2	271	c.210C>T	c.(208-210)ggC>ggT	p.G70G	SLC35G1_ENST00000427197.1_Silent_p.G71G			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	71						integral to membrane											CTGGACTTGGCTTGTTTTACA	0.388000													5	72					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103899296	103899296	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:103899296T>C	ENST00000278070.2	+	5	1070	c.1031T>C	c.(1030-1032)gTa>gCa	p.V344A	PPRC1_ENST00000413464.2_Missense_Mutation_p.V344A	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GAGGGCTGCGTAGTGCTGGAG	0.612000													6	273					0	0	1	0	0
SLC37A4	2542	broad.mit.edu	37	11	118898461	118898461	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118898461G>A	ENST00000545985.1	-	5	1259	c.503C>T	c.(502-504)aCg>aTg	p.T168M	SLC37A4_ENST00000525102.1_5'UTR|SLC37A4_ENST00000538950.1_Missense_Mutation_p.T95M|SLC37A4_ENST00000357590.5_Missense_Mutation_p.T168M|SLC37A4_ENST00000330775.7_Missense_Mutation_p.T168M	NM_001164277.1|NM_001467.5	NP_001157749.1|NP_001458.1	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 4	168					glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	6	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		TAGGGCCAGCGTGCTGCGCCA	0.607000													13	34					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64784234	64784234	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:64784234G>A	ENST00000543942.2	-	1	738	c.112C>T	c.(112-114)Cca>Tca	p.P38S	RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000333722.5_Missense_Mutation_p.P38S	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	38										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		ACGATGCATGGCTCGTAGGCG	0.642000													5	148					0	0	1	0	0
DPP9	91039	broad.mit.edu	37	19	4682811	4682811	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:4682811A>G	ENST00000262960.9	-	20	2648	c.2371T>C	c.(2371-2373)Tac>Cac	p.Y791H	DPP9_ENST00000598800.1_Missense_Mutation_p.Y762H|AC005594.3_ENST00000381796.1_RNA|DPP9_ENST00000594671.1_Missense_Mutation_p.Y762H	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	762					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CCTGTGTCGTAGGCCATCCAG	0.627000													4	7					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108725919	108725919	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:108725919T>A	ENST00000232603.5	-	18	1806	c.1724A>T	c.(1723-1725)gAc>gTc	p.D575V	MORC1_ENST00000483760.1_Intron	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	575					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGTGATTTCGTCCACTGGTAT	0.368000													15	56					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84223312	84223312	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:84223312T>C	ENST00000405413.2	-	11	1452	c.1316A>G	c.(1315-1317)aAc>aGc	p.N439S	HPSE_ENST00000311412.5_Missense_Mutation_p.N439S|HPSE_ENST00000512196.1_Missense_Mutation_p.N365S|HPSE_ENST00000513463.1_Missense_Mutation_p.N381S	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	439					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CTTGTCAGTGTTTGTGCAATG	0.413000													21	68					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212473	26212473	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:26212473C>T	ENST00000379034.1	+	2	659	c.510C>T	c.(508-510)gcC>gcT	p.A170A		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	170										breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						ATGTGGCTGCCGAGGGTGAAG	0.517000													27	32					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21551831	21551831	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:21551831T>A	ENST00000415912.2	-	17	2029	c.1904A>T	c.(1903-1905)aAc>aTc	p.N635I	ECE1_ENST00000436918.2_Missense_Mutation_p.N651I|ECE1_ENST00000264205.6_Missense_Mutation_p.N648I|ECE1_ENST00000374893.6_Missense_Mutation_p.N651I|ECE1_ENST00000357071.4_Missense_Mutation_p.N639I	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	651					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		CACGCTGTAGTTGCTGTACTG	0.632000													18	65					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657959	72657959	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:72657959T>C	ENST00000425256.1	-	0	1952					NR_002164.1																						catgaaggagtcgatttcttc	0.507000													26	76					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6427516	6427516	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6427516T>C	ENST00000449001.2	+	10	1603	c.1109T>C	c.(1108-1110)gTt>gCt	p.V370A	PLEKHG6_ENST00000536531.1_Missense_Mutation_p.V402A|PLEKHG6_ENST00000396988.3_Missense_Mutation_p.V402A|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.V402A	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	402					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						ATGCTGGGGGTTGCATCTGAG	0.652000													19	97					0	0	1	0	0
CCNA1	8900	broad.mit.edu	37	13	37012300	37012300	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:37012300A>C	ENST00000418263.1	+	4	988	c.638A>C	c.(637-639)gAa>gCa	p.E213A	CCNA1_ENST00000449823.1_Missense_Mutation_p.E170A|CCNA1_ENST00000255465.4_Missense_Mutation_p.E214A|CCNA1_ENST00000440264.1_Missense_Mutation_p.E170A	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	214					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		TATGCTGAAGAAATTTATCAG	0.393000													34	100					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187447147	187447147	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:187447147C>T	ENST00000406870.2	-	5	1412	c.1046G>A	c.(1045-1047)aGc>aAc	p.S349N	RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.S349N|RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000232014.4_Missense_Mutation_p.S349N	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	349					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		ATTCTTACTGCTGCAGGACTC	0.582000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								64	280					0	0	1	0	0
STX18	53407	broad.mit.edu	37	4	4422626	4422626	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:4422626C>T	ENST00000306200.2	-	10	940	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	STX18_ENST00000505286.1_Missense_Mutation_p.E293K	NM_016930.2	NP_058626.1	Q9P2W9	STX18_HUMAN	syntaxin 18	293	t-SNARE coiled-coil homology.				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	5				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		TTGATATTTTCAGTTGCCCCC	0.468000													29	155					0	0	1	0	0
DBP	1628	broad.mit.edu	37	19	49134122	49134122	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49134122C>T	ENST00000222122.5	-	4	1393	c.950G>A	c.(949-951)cGa>cAa	p.R317Q	DBP_ENST00000593500.1_Missense_Mutation_p.R115Q|DBP_ENST00000599385.1_Missense_Mutation_p.R115Q	NM_001352.3	NP_001343.2	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box) binding protein	317					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		GGCCTGGTATCGGGACAGCAC	0.687000													5	8					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51191246	51191246	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:51191246T>C	ENST00000293441.1	-	17	2260	c.2242A>G	c.(2242-2244)Acg>Gcg	p.T748A	SHANK1_ENST00000391814.1_Missense_Mutation_p.T748A|SHANK1_ENST00000391813.1_Missense_Mutation_p.T135A|SHANK1_ENST00000359082.3_Missense_Mutation_p.T739A	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	748	PDZ.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACCATCAGCGTGTTGCCCCCT	0.607000													32	65					0	0	1	0	0
HEY2	23493	broad.mit.edu	37	6	126080822	126080822	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:126080822A>G	ENST00000368364.3	+	5	1085	c.888A>G	c.(886-888)gcA>gcG	p.A296A	HEY2_ENST00000368365.1_Silent_p.A250A	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	296	Ala-rich.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CAGCAGCAGCAGTGGCCGCGG	0.642000													14	239					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155632272	155632272	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:155632272A>G	ENST00000496455.1	+	8	1286	c.951A>G	c.(949-951)agA>agG	p.R317R	GMPS_ENST00000295920.7_Silent_p.R218R	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	317					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ATGAAGATAGAACCCCACGGA	0.363000			T	MLL	AML								31	73					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	17994513	17994513	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17994513C>T	ENST00000222248.3	+	11	1613	c.1266C>T	c.(1264-1266)gtC>gtT	p.V422V		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	422					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TCATGGGAGTCATCAGCGGCC	0.682000													35	120					0	0	1	0	0
ZNF195	7748	broad.mit.edu	37	11	3392921	3392921	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:3392921A>G	ENST00000354599.6	-	2	120	c.16T>C	c.(16-18)Ttc>Ctc	p.F6L	ZNF195_ENST00000429541.2_Missense_Mutation_p.F10L|ZNF195_ENST00000399602.4_Missense_Mutation_p.F6L|ZNF195_ENST00000528796.1_Missense_Mutation_p.F6L|ZNF195_ENST00000343338.7_Missense_Mutation_p.F10L|ZNF195_ENST00000527386.1_5'UTR|ZNF195_ENST00000526601.1_Missense_Mutation_p.F10L|ZNF195_ENST00000438262.2_Missense_Mutation_p.F10L|ZNF195_ENST00000005082.9_Missense_Mutation_p.F6L	NM_001242843.1|NM_001256825.1|NM_007152.4	NP_001229772.1|NP_001243754.1|NP_009083.2	O14628	ZN195_HUMAN	zinc finger protein 195	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)	17		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ACATCCCTGAACGTCAACAGA	0.443000													4	124					0	0	1	0	0
SAR1A	56681	broad.mit.edu	37	10	71912253	71912253	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:71912253C>T	ENST00000373238.1	-	7	933	c.576G>A	c.(574-576)tgG>tgA	p.W192*	SAR1A_ENST00000458634.2_Nonsense_Mutation_p.W149*|SAR1A_ENST00000373242.1_Nonsense_Mutation_p.W192*|SAR1A_ENST00000373241.4_Nonsense_Mutation_p.W192*|SAR1A_ENST00000431664.2_Nonsense_Mutation_p.W192*			Q9NR31	SAR1A_HUMAN	SAR1 homolog A (S. cerevisiae)	192					ER to Golgi vesicle-mediated transport|intracellular protein transport	Golgi apparatus	GTP binding|GTPase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)	6						ACTGGGAGAGCCAGCGGAAAC	0.463000													15	61					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43165917	43165917	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:43165917A>G	ENST00000352483.2	-	7	1145		c.e7+1		RIPK4_ENST00000332512.3_Splice_Site|RIPK4_ENST00000544709.1_Splice_Site|RIPK4_ENST00000542057.1_Splice_Site			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4							cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AGGACTCGTTACCTCGCTCCT	0.567000													41	91					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140729234	140729234	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140729234T>C	ENST00000460843.1	+	27	3753	c.3726T>C	c.(3724-3726)taT>taC	p.Y1242Y		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1242	Interaction with histone H3.|SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GGTTTGACTATGGAGAGCGCT	0.607000													17	45					0	0	1	0	0
MFN1	55669	broad.mit.edu	37	3	179080157	179080157	+	Silent	SNP	A	A	G	rs149335403	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:179080157A>G	ENST00000471841.1	+	5	549	c.423A>G	c.(421-423)caA>caG	p.Q141Q	MFN1_ENST00000280653.7_Silent_p.Q141Q|MFN1_ENST00000263969.5_Silent_p.Q141Q	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	141					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CAGTTAATCAACTGGCCCATG	0.363000													17	69					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	983025	983025	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:983025G>A	ENST00000379370.2	+	21	3639	c.3589G>A	c.(3589-3591)Ggc>Agc	p.G1197S		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1197	SEA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCTGGGGCCCGGCAAATCCGT	0.617000													4	110					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161512474	161512474	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:161512474A>G	ENST00000392142.4	+	12	3185	c.3037A>G	c.(3037-3039)Aca>Gca	p.T1013A	MAP3K4_ENST00000348824.7_Missense_Mutation_p.T1013A|MAP3K4_ENST00000366920.2_Missense_Mutation_p.T1013A|MAP3K4_ENST00000366919.2_Missense_Mutation_p.T1013A	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1013					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CCACATGTTCACATCAGAATT	0.423000													54	158					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83455722	83455722	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:83455722C>A	ENST00000334574.8	-	2	602	c.421G>T	c.(421-423)Ggc>Tgc	p.G141C	FSD2_ENST00000541889.1_Missense_Mutation_p.G141C			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	141										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						TGGCACTGGCCTGCTGAGCCC	0.602000													22	92					1.55469e-16	1.63288e-16	1	1	0
CHST2	9435	broad.mit.edu	37	3	142840276	142840276	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:142840276G>C	ENST00000309575.3	+	2	2002	c.618G>C	c.(616-618)ccG>ccC	p.P206P		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	206					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						AACTGTATCCGGGGGACGCCG	0.602000													50	126					0	0	1	0	0
IL7	3574	broad.mit.edu	37	8	79646036	79646036	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:79646036T>G	ENST00000263851.4	-	6	1046	c.446A>C	c.(445-447)aAa>aCa	p.K149T	IL7_ENST00000520269.1_Missense_Mutation_p.K105T|IL7_ENST00000519833.1_Intron|IL7_ENST00000541183.1_Missense_Mutation_p.K36T	NM_000880.3|NM_001199886.1|NM_001199887.1	NP_000871.1|NP_001186815.1|NP_001186816.1	P13232	IL7_HUMAN	interleukin 7	149					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding			endometrium(2)|large_intestine(2)|lung(1)	5						GTCATTCAGTTTTTTCTGTTC	0.244000													10	76					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146031549	146031549	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:146031549A>C	ENST00000296577.4	+	7	1081	c.566A>C	c.(565-567)gAc>gCc	p.D189A	ABCE1_ENST00000502803.1_Intron	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	189	ABC transporter 1.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					TCTATTTTGGACCGAAAAGAT	0.299000													40	102					0	0	1	0	0
LSM14A	26065	broad.mit.edu	37	19	34687588	34687588	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:34687588G>A	ENST00000544216.3	+	3	412	c.335G>A	c.(334-336)gGa>gAa	p.G112E	LSM14A_ENST00000540746.2_Missense_Mutation_p.G112E|LSM14A_ENST00000433627.5_Missense_Mutation_p.G112E	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	112					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					GGTTCTTATGGACCTTTCGGC	0.433000													47	126					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82372869	82372869	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:82372869A>G	ENST00000370728.1	+	6	886	c.241A>G	c.(241-243)Aat>Gat	p.N81D	LPHN2_ENST00000370713.1_Missense_Mutation_p.N81D|LPHN2_ENST00000319517.6_Missense_Mutation_p.N81D|LPHN2_ENST00000370730.1_Missense_Mutation_p.N81D|LPHN2_ENST00000370725.1_Missense_Mutation_p.N81D|LPHN2_ENST00000370721.1_Missense_Mutation_p.N81D|LPHN2_ENST00000370727.1_Missense_Mutation_p.N81D|LPHN2_ENST00000271029.4_Missense_Mutation_p.N81D|LPHN2_ENST00000370715.1_Missense_Mutation_p.N81D|LPHN2_ENST00000394879.1_Missense_Mutation_p.N81D|LPHN2_ENST00000359929.3_Missense_Mutation_p.N81D|LPHN2_ENST00000370717.2_Missense_Mutation_p.N81D|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000370723.1_Missense_Mutation_p.N81D|LPHN2_ENST00000335786.5_Missense_Mutation_p.N81D			O95490	LPHN2_HUMAN	latrophilin 2	81	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TCAGATGGAGAATACAGACTG	0.423000													4	147					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9024886	9024886	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9024886T>C	ENST00000397910.4	-	16	37179	c.36976A>G	c.(36976-36978)Acc>Gcc	p.T12326A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12328	SEA 2.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGTCATTGGTCAGTTTGCTT	0.557000													68	212					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129910	6129910	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:6129910A>G	ENST00000316529.3	+	1	997	c.902A>G	c.(901-903)cAc>cGc	p.H301R	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCAGGATGCACAAACTCAGA	0.493000													54	118					0	0	1	0	0
TADA2A	6871	broad.mit.edu	37	17	35830624	35830624	+	Missense_Mutation	SNP	G	G	A	rs149845906		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:35830624G>A	ENST00000394395.2	+	13	1189	c.1016G>A	c.(1015-1017)cGg>cAg	p.R339Q	TADA2A_ENST00000591992.1_3'UTR|TADA2A_ENST00000225396.6_Missense_Mutation_p.R339Q	NM_001166105.1	NP_001159577.1	O75478	TAD2A_HUMAN	transcriptional adaptor 2A	339					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding	p.R339Q(2)		breast(4)|cervix(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)|skin(1)	13						TGGCTCCGCCGGCAAGCTGAC	0.512000													4	119					0	0	1	0	0
EIF4E	1977	broad.mit.edu	37	4	99809056	99809056	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:99809056T>C	ENST00000450253.2	-	4	1793	c.269A>G	c.(268-270)gAc>gGc	p.D90G	EIF4E_ENST00000280892.6_Missense_Mutation_p.D110G|EIF4E_ENST00000505992.1_Missense_Mutation_p.D90G|EIF4E_ENST00000504432.1_Missense_Mutation_p.D118G	NM_001968.3	NP_001959.1	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	90					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)		AAGTGAGTAGTCACAGCCAGG	0.294000													8	20					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605320	140605320	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140605320G>C	ENST00000239449.4	+	1	2243	c.2243G>C	c.(2242-2244)aGc>aCc	p.S748T	PCDHB14_ENST00000515856.2_Missense_Mutation_p.S595T	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		748					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTCCCAGAGCTACCAATAC	0.582000													54	214					0	0	1	0	0
GSDMD	79792	broad.mit.edu	37	8	144644191	144644191	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144644191A>T	ENST00000526406.1	+	11	1769	c.886A>T	c.(886-888)Acc>Tcc	p.T296S	GSDMD_ENST00000262580.4_Missense_Mutation_p.T296S|GSDMD_ENST00000533063.1_Missense_Mutation_p.T344S	NM_001166237.1	NP_001159709.1	P57764	GSDMD_HUMAN	gasdermin D	296										breast(1)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	12						AGAGGTGGAGACCATCTCCAA	0.642000													18	88					0	0	1	0	0
ZNF268	10795	broad.mit.edu	37	12	133779106	133779106	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133779106C>T	ENST00000536435.2	+	6	1164	c.834C>T	c.(832-834)tgC>tgT	p.C278C	ZNF268_ENST00000228289.5_Silent_p.C278C|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000537565.1_Silent_p.C117C|ZNF268_ENST00000542711.2_3'UTR|ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000542986.2_3'UTR	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	278						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CCTTTGGATGCAGCTGTTGTG	0.403000													5	12					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36594923	36594923	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:36594923T>G	ENST00000299440.5	+	2	181	c.69T>G	c.(67-69)atT>atG	p.I23M		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	23	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ACCCACATATTAAATTTTCAG	0.448000									Familial Hemophagocytic Lymphohistiocytosis				4	106					0	0	1	0	0
BHLHE22	27319	broad.mit.edu	37	8	65493811	65493811	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:65493811G>A	ENST00000321870.1	+	1	998	c.464G>A	c.(463-465)cGc>cAc	p.R155H	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	155	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						AGCGACGGTCGCTGCGAGCTC	0.751000													8	10					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6476142	6476142	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:6476142C>T	ENST00000297056.6	-	3	439	c.270G>A	c.(268-270)ccG>ccA	p.P90P	DAGLB_ENST00000436575.1_Silent_p.P49P|DAGLB_ENST00000425398.2_Silent_p.P90P|DAGLB_ENST00000428902.2_Intron|DAGLB_ENST00000421761.2_Intron|DAGLB_ENST00000479922.2_5'UTR	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	90					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		TAGACTTCCGCGGTCCAGGGT	0.498000													43	127					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2776744	2776744	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:2776744T>C	ENST00000380605.2	-	10	1370	c.1306A>G	c.(1306-1308)Aat>Gat	p.N436D		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	436					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						TCAGCAAAATTATGGTTAAGA	0.577000													24	95					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74770751	74770751	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:74770751A>G	ENST00000412021.2	-	14	1746	c.1413T>C	c.(1411-1413)gtT>gtC	p.V471V	P4HA1_ENST00000307116.2_Silent_p.V471V|P4HA1_ENST00000440381.1_Silent_p.V453V|P4HA1_ENST00000394890.2_Silent_p.V471V|P4HA1_ENST00000263556.3_Silent_p.V471V|P4HA1_ENST00000373008.2_Silent_p.V471V	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	471	Fe2OG dioxygenase.					endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CACTAGCTCCAACTTCAGGAA	0.373000													21	70					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19076689	19076689	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:19076689A>G	ENST00000380502.3	-	11	1672	c.1205T>C	c.(1204-1206)tTa>tCa	p.L402S	HAUS6_ENST00000380496.1_Missense_Mutation_p.L266S	NM_017645.3	NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	402					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CATTGGTGGTAAAAGATCTAC	0.338000													15	55					0	0	1	0	0
SLC39A5	283375	broad.mit.edu	37	12	56629106	56629106	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56629106C>T	ENST00000266980.4	+	5	1093	c.800C>T	c.(799-801)cCg>cTg	p.P267L	SLC39A5_ENST00000454355.2_Missense_Mutation_p.P267L	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	267					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CATCTGCTACCGCATGTATGT	0.607000													56	150					0	0	1	0	0
PDCD10	11235	broad.mit.edu	37	3	167405034	167405034	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:167405034A>G	ENST00000392750.2	-	8	962	c.545T>C	c.(544-546)tTt>tCt	p.F182S	PDCD10_ENST00000473645.2_Missense_Mutation_p.F182S|PDCD10_ENST00000471885.1_Missense_Mutation_p.F182S|PDCD10_ENST00000497056.2_Missense_Mutation_p.F182S|PDCD10_ENST00000461494.1_Missense_Mutation_p.F182S|PDCD10_ENST00000470131.1_Missense_Mutation_p.F182S|PDCD10_ENST00000492396.1_Missense_Mutation_p.F119S|PDCD10_ENST00000487947.2_Missense_Mutation_p.F182S	NM_007217.3	NP_009148.2	Q9BUL8	PDC10_HUMAN	programmed cell death 10	182					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			central_nervous_system(1)|kidney(1)|lung(8)|urinary_tract(2)	12						GCCATCTTTAAAATACGTTTT	0.264000													16	35					0	0	1	0	0
MDH1B	130752	broad.mit.edu	37	2	207619851	207619851	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:207619851C>T	ENST00000374412.3	-	5	1067	c.792G>A	c.(790-792)aaG>aaA	p.K264K	MDH1B_ENST00000449792.1_Silent_p.K166K|MDH1B_ENST00000454776.2_Silent_p.K264K|MDH1B_ENST00000392214.2_Intron	NM_001039845.1	NP_001034934.1	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	264					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(14)|ovary(4)|stomach(1)	34				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		GTAAAACTGTCTTCAGGTTTA	0.502000													33	106					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821729	72821729	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:72821729G>A	ENST00000268489.5	-	10	11118	c.10446C>T	c.(10444-10446)agC>agT	p.S3482S	ZFHX3_ENST00000397992.5_Silent_p.S2568S	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3482					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ACTTCAGGTGGCTCCTCGCTG	0.642000													24	88					0	0	1	0	0
MZF1	7593	broad.mit.edu	37	19	59074233	59074233	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:59074233T>C	ENST00000215057.2	-	6	1971	c.1411A>G	c.(1411-1413)Aag>Gag	p.K471E	MZF1_ENST00000599369.1_Missense_Mutation_p.K471E|AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000594234.1_3'UTR|AC016629.8_ENST00000600534.1_RNA|AC016629.8_ENST00000600726.1_RNA	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	471	Gly/Pro-rich.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GCCGGGGGCTTAGCGCCAGGG	0.726000													5	9					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99472871	99472871	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:99472871A>G	ENST00000268035.6	+	14	3478	c.2867A>G	c.(2866-2868)tAc>tGc	p.Y956C	IGF1R_ENST00000558762.1_Missense_Mutation_p.Y955C	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	956					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ATTATGCTGTACGTCTTCCAT	0.448000													18	75					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129236439	129236439	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:129236439T>C	ENST00000296266.3	+	28	3736		c.e28+2		IFT122_ENST00000440957.2_Splice_Site|IFT122_ENST00000348417.2_Splice_Site|IFT122_ENST00000431818.2_Splice_Site|IFT122_ENST00000347300.2_Splice_Site|IFT122_ENST00000349441.2_Splice_Site|IFT122_ENST00000507564.1_Splice_Site|IFT122_ENST00000504021.1_Splice_Site	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)						camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						CAAACAACAGTATCCATGCCC	0.602000													44	119					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64622229	64622229	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64622229A>G	ENST00000320631.3	-	5	1435	c.1181T>C	c.(1180-1182)aTg>aCg	p.M394T	EHD1_ENST00000488711.1_5'UTR|EHD1_ENST00000359393.2_Missense_Mutation_p.M394T	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	394					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						CACCATCACCATCAGCCGCGC	0.642000													107	304					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42510946	42510946	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42510946T>C	ENST00000262895.3	-	15	1887	c.1888A>G	c.(1888-1890)Atc>Gtc	p.I630V	GRIK5_ENST00000593562.1_Missense_Mutation_p.I630V|GRIK5_ENST00000301218.4_Missense_Mutation_p.I630V	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	630						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GAGATGATGATCAAGGTGAAG	0.652000													6	39					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2816806	2816806	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2816806C>T	ENST00000301740.8	+	11	6826	c.6277C>T	c.(6277-6279)Cct>Tct	p.P2093S		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2093	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						ATCTGCTACTCCTCCAGCAAC	0.517000													31	241					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57358360	57358360	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:57358360G>A	ENST00000518770.1	-	3	306	c.153C>T	c.(151-153)cgC>cgT	p.R51R	PENK_ENST00000451791.2_Intron|PENK_ENST00000523051.1_Intron|PENK_ENST00000314922.3_Intron			P01210	PENK_HUMAN	proenkephalin	47					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			AACACTCGCCGCGCGCAACAC	0.677000													84	123					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61769157	61769157	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:61769157C>T	ENST00000361357.3	+	15	1820	c.1502C>T	c.(1501-1503)aCg>aTg	p.T501M	MAP3K3_ENST00000579585.1_Missense_Mutation_p.T501M|MAP3K3_ENST00000577395.1_Missense_Mutation_p.T466M|MAP3K3_ENST00000361733.3_Missense_Mutation_p.T470M|MAP3K3_ENST00000584573.1_Missense_Mutation_p.T497M	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	470	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						CGAAAGTACACGCGGCAGATC	0.577000													78	215					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87474017	87474017	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:87474017C>A	ENST00000517970.1	+	24	2918	c.2611C>A	c.(2611-2613)Caa>Aaa	p.Q871K	WWP1_ENST00000265428.4_Missense_Mutation_p.Q871K|WWP1_ENST00000341922.2_Missense_Mutation_p.Q741K|WWP1_ENST00000349423.2_Missense_Mutation_p.Q653K	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	871	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						TAATGGGCCTCAAAAGTTTTG	0.363000													48	101					2.43468e-25	2.57753e-25	1	1	0
FCRL5	83416	broad.mit.edu	37	1	157509085	157509085	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:157509085G>A	ENST00000361835.3	-	7	1350	c.1193C>T	c.(1192-1194)aCa>aTa	p.T398I	FCRL5_ENST00000356953.4_Missense_Mutation_p.T398I|FCRL5_ENST00000368190.3_Missense_Mutation_p.T398I|FCRL5_ENST00000368191.3_Missense_Mutation_p.T313I|FCRL5_ENST00000368189.3_Missense_Mutation_p.T398I	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	398	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ACAGTGAAGTGTCACCTTGGC	0.522000													17	60					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34125525	34125525	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:34125525T>C	ENST00000297161.2	+	14	1940	c.1566T>C	c.(1564-1566)ttT>ttC	p.F522F	BMPER_ENST00000426693.1_Silent_p.F522F	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	522	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						TGGATGACTTTGCTGAATCTT	0.473000													26	74					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104705131	104705131	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:104705131T>C	ENST00000526691.1	+	3	640	c.184T>C	c.(184-186)Tcc>Ccc	p.S62P	TXNRD1_ENST00000503506.2_Missense_Mutation_p.S10P|TXNRD1_ENST00000354940.6_Missense_Mutation_p.S10P|TXNRD1_ENST00000378070.4_Missense_Mutation_p.S109P|TXNRD1_ENST00000427956.1_Missense_Mutation_p.S125P|TXNRD1_ENST00000429002.2_Missense_Mutation_p.S160P|TXNRD1_ENST00000525566.1_Missense_Mutation_p.S160P|TXNRD1_ENST00000388854.3_Missense_Mutation_p.S62P|TXNRD1_ENST00000397736.2_Missense_Mutation_p.S54P|TXNRD1_ENST00000524698.1_Missense_Mutation_p.S10P|TXNRD1_ENST00000526390.1_Missense_Mutation_p.S54P|TXNRD1_ENST00000542918.1_Missense_Mutation_p.S60P|TXNRD1_ENST00000540716.1_Intron|TXNRD1_ENST00000526950.1_Missense_Mutation_p.S79P|TXNRD1_ENST00000529546.1_Intron	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	160	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						TCTTCCCAAGTCCTATGACTA	0.438000													8	24					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939533	12939533	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:12939533A>G	ENST00000235349.5	-	4	1339	c.1269T>C	c.(1267-1269)ggT>ggC	p.G423G		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	423										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TACCATCAGCACCATAACTCT	0.512000													20	871					0	0	1	0	0
ZNF16	7564	broad.mit.edu	37	8	146157440	146157440	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:146157440T>C	ENST00000276816.4	-	4	919	c.733A>G	c.(733-735)Acc>Gcc	p.T245A	ZNF16_ENST00000394909.2_Missense_Mutation_p.T245A	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TGGCTGAAGGTTTTCCCACAA	0.463000													55	261					0	0	1	0	0
RBAK	57786	broad.mit.edu	37	7	5104851	5104851	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:5104851A>G	ENST00000396912.1	+	5	2283	c.1764A>G	c.(1762-1764)gtA>gtG	p.V588V	RBAK_ENST00000353796.3_Silent_p.V588V|RBAK_ENST00000407184.1_Intron|RBAK_ENST00000396904.2_Intron	NM_021163.3	NP_066986.1	Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	588	Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		ATCAAAGAGTACACACAGGCG	0.378000													5	49					0	0	1	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310089	178310089	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:178310089A>G	ENST00000322434.3	+	5	862	c.636A>G	c.(634-636)aaA>aaG	p.K212K		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCAGAGAAACGCTATAAAT	0.299000													29	102					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48842449	48842449	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:48842449A>G	ENST00000314191.2	-	18	2072	c.2016T>C	c.(2014-2016)atT>atC	p.I672I	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.I672I	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	672					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TTCTTACTGTAATAGAAAGCA	0.323000								Non-homologous end-joining					3	68					0	0	1	0	0
WDR4	10785	broad.mit.edu	37	21	44274700	44274700	+	Missense_Mutation	SNP	C	C	G	rs111539710		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:44274700C>G	ENST00000398208.2	-	8	822	c.763G>C	c.(763-765)Gag>Cag	p.E255Q	WDR4_ENST00000492742.1_5'UTR|WDR4_ENST00000330317.2_Missense_Mutation_p.E255Q	NM_001260474.1|NM_001260475.1|NM_001260476.1|NM_018669.5	NP_001247403.1|NP_001247404.1|NP_001247405.1|NP_061139.2	P57081	WDR4_HUMAN	WD repeat domain 4	255					tRNA modification	cytoplasm|nucleoplasm	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|ovary(2)	11				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		ACGCAGTTCTCCTGGCACCAG	0.622000													10	34					0	0	1	0	0
ZCCHC3	85364	broad.mit.edu	37	20	279084	279084	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:279084A>G	ENST00000382352.3	+	1	1348	c.857A>G	c.(856-858)aAa>aGa	p.K286R		NM_033089.6	NP_149080.2	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	286							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GTGCCGGTGAAAGTGACCGAC	0.617000													9	152					0	0	1	0	0
PARL	55486	broad.mit.edu	37	3	183584466	183584466	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:183584466C>T	ENST00000317096.4	-	3	469	c.409G>A	c.(409-411)Gct>Act	p.A137T	PARL_ENST00000435888.1_Missense_Mutation_p.A137T|PARL_ENST00000311101.5_Missense_Mutation_p.A137T	NM_018622.5	NP_061092.3	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like	137			A -> G (in dbSNP:rs4912470).		proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity			endometrium(2)|large_intestine(3)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	17	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AACCAATCAGCTTTTATACCA	0.353000													17	75					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37866346	37866346	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:37866346C>T	ENST00000406381.2	+	8	1071	c.561C>T	c.(559-561)cgC>cgT	p.R187R	ERBB2_ENST00000540147.1_Silent_p.R187R|ERBB2_ENST00000541774.1_Silent_p.R202R|ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000584601.1_Silent_p.R187R|ERBB2_ENST00000584450.1_Silent_p.R217R|ERBB2_ENST00000540042.1_Silent_p.R187R|ERBB2_ENST00000269571.5_Silent_p.R217R|ERBB2_ENST00000578199.1_Silent_p.R187R	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	217					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CAGTGACGCGCACTGTCTGTG	0.662000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			61	116					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267222	107267222	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:107267222A>G	ENST00000334726.2	+	1	768	c.679A>G	c.(679-681)Aga>Gga	p.R227G		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CAGTATCCTGAGAATCAGCTC	0.478000													4	186					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72866908	72866908	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:72866908C>T	ENST00000261180.4	+	5	1493	c.1397C>T	c.(1396-1398)gCt>gTt	p.A466V		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	466					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GAAGGGTTTGCTCACTACTTT	0.408000													6	227					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43438825	43438825	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:43438825C>T	ENST00000372851.3	-	1	154	c.88G>A	c.(88-90)Gag>Aag	p.E30K	RIMS4_ENST00000541604.2_Missense_Mutation_p.E30K	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	30					exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				CCTGCGTCCTCGTCGTCGAAG	0.731000													6	18					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20497357	20497357	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:20497357A>G	ENST00000361078.2	-	7	988	c.966T>C	c.(964-966)gaT>gaC	p.D322D	PUM2_ENST00000403432.1_Silent_p.D322D|PUM2_ENST00000319801.5_Silent_p.D322D|PUM2_ENST00000536417.1_Silent_p.D266D|PUM2_ENST00000338086.5_Silent_p.D322D			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	322	Ala-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTATACGGATCGGTCCCTG	0.418000													9	27					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458649	20458649	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:20458649G>A	ENST00000426804.1	-	1	3137	c.2653C>T	c.(2653-2655)Cgg>Tgg	p.R885W		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AGCCCCCGCCGGCCATCCTCA	0.597000													9	45					0	0	1	0	0
SDAD1	55153	broad.mit.edu	37	4	76891490	76891490	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:76891490T>C	ENST00000356260.5	-	10	973	c.855A>G	c.(853-855)tcA>tcG	p.S285S	SDAD1_ENST00000395711.4_Silent_p.S248S|SDAD1_ENST00000513089.1_5'UTR	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	285					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AGTGAATGGCTGAAAAGTTAA	0.388000													14	57					0	0	1	0	0
CAPN7	23473	broad.mit.edu	37	3	15274052	15274052	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:15274052T>C	ENST00000253693.2	+	10	1312	c.1059T>C	c.(1057-1059)gtT>gtC	p.V353V		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	353	Calpain catalytic.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						AGTTACCTGTTGATCACAAGG	0.343000													16	54					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	427785	427785	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:427785T>C	ENST00000316418.5	+	8	798	c.754T>C	c.(754-756)Tgc>Cgc	p.C252R	AHRR_ENST00000505113.1_Intron|AHRR_ENST00000512529.1_Intron|AHRR_ENST00000506456.1_Intron	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCTGCGGCTCTGCTGTCCCGA	0.607000													33	97					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10906067	10906067	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10906067A>G	ENST00000314646.5	+	9	1312	c.1148A>G	c.(1147-1149)gAc>gGc	p.D383G	DNM2_ENST00000389253.4_Missense_Mutation_p.D383G|DNM2_ENST00000359692.6_Missense_Mutation_p.D383G|DNM2_ENST00000355667.6_Missense_Mutation_p.D383G|DNM2_ENST00000585892.1_Missense_Mutation_p.D383G|DNM2_ENST00000408974.4_Missense_Mutation_p.D383G			P50570	DYN2_HUMAN	dynamin 2	383					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GACGAGAAGGACTTACGACGG	0.567000			"""F, N, Splice, Mis, O"""		ETP ALL								33	96					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44589503	44589503	+	Splice_Site	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44589503C>A	ENST00000322927.2	-	11	1765	c.1665_splice	c.e11+1	p.P555_splice	ZNF335_ENST00000426788.1_Splice_Site_p.P400_splice	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CCAGACTCACCGGATCTGGCC	0.582000													9	12					3.09899e-07	3.1815e-07	1	1	0
UBR5	51366	broad.mit.edu	37	8	103293654	103293654	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:103293654A>G	ENST00000520539.1	-	41	6396	c.5790T>C	c.(5788-5790)gaT>gaC	p.D1930D	UBR5_ENST00000521922.1_Silent_p.D1924D|UBR5_ENST00000220959.4_Silent_p.D1930D	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1930					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CAGAATGCTCATCATTATGAG	0.423000													14	163					0	0	1	0	0
ZNF217	7764	broad.mit.edu	37	20	52198633	52198633	+	Missense_Mutation	SNP	C	C	T	rs150961799		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:52198633C>T	ENST00000371471.2	-	2	1158	c.733G>A	c.(733-735)Ggt>Agt	p.G245S	ZNF217_ENST00000302342.3_Missense_Mutation_p.G245S			O75362	ZN217_HUMAN	zinc finger protein 217	245					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CTGCTGGTACCGAAAGCAGTT	0.483000													46	124					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232601047	232601047	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:232601047C>T	ENST00000366630.1	-	8	2717	c.2359G>A	c.(2359-2361)Gca>Aca	p.A787T	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.A787T			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	787	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GCATTTTCTGCATTGATTACT	0.468000													43	122					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78893979	78893979	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:78893979T>C	ENST00000326828.5	-	5	1389	c.1005A>G	c.(1003-1005)acA>acG	p.T335T	CHRNA3_ENST00000348639.3_Silent_p.T335T	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	335					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCATTGTGTGTGTCGTCGGGG	0.522000													43	112					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112174922	112174922	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:112174922A>G	ENST00000457016.1	+	16	4011	c.3631A>G	c.(3631-3633)Atg>Gtg	p.M1211V	APC_ENST00000508376.2_Missense_Mutation_p.M1211V|APC_ENST00000257430.4_Missense_Mutation_p.M1211V|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1211	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.M1211fs*6(1)|p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AACCGAACATATGTCTTCAAG	0.403000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			17	87					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7032981	7032981	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:7032981A>G	ENST00000389658.3	-	15	2257		c.e15+1			NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1						axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGAAGCGTCACCTCACAGGA	0.502000													7	14					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5593976	5593976	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:5593976C>T	ENST00000252542.4	-	15	2397	c.2133G>A	c.(2131-2133)gaG>gaA	p.E711E		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	711	Arg-rich.|Glu-rich.|Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GGCGCCGCAGCTCCTCGCGCT	0.741000													4	9					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90432762	90432762	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:90432762A>G	ENST00000369393.3	-	40	5994	c.5879T>C	c.(5878-5880)gTt>gCt	p.V1960A	MDN1_ENST00000428876.1_Missense_Mutation_p.V1960A			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1960					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGACTGGTCAACCAGCATCAA	0.473000													6	276					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	132973733	132973733	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:132973733C>T	ENST00000253861.4	+	3	363	c.334C>T	c.(334-336)Cgg>Tgg	p.R112W	EXOC4_ENST00000393161.2_Missense_Mutation_p.R112W|EXOC4_ENST00000539845.1_Missense_Mutation_p.R11W	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	112					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GGATGAGCTTCGGAAACTGTG	0.433000													24	77					0	0	1	0	0
ZNF788	388507	broad.mit.edu	37	19	12223763	12223763	+	Silent	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:12223763T>G	ENST00000339302.4	+	3	2038	c.1401T>G	c.(1399-1401)acT>acG	p.T467T	ZNF788_ENST00000430298.2_3'UTR|ZNF788_ENST00000397759.3_Silent_p.T86T|ZNF20_ENST00000600335.1_Intron					zinc finger family member 788											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	2						ATGAAATGACTCACACTGGAG	0.448000													4	33					0	0	1	0	0
SEPT7	989	broad.mit.edu	37	7	35913282	35913282	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:35913282A>G	ENST00000494488.2	+	5	367	c.367A>G	c.(367-369)Aaa>Gaa	p.K123E	SEPT7_ENST00000399034.2_Missense_Mutation_p.K138E|SEPT7_ENST00000435235.1_Missense_Mutation_p.K84E|SEPT7_ENST00000399035.3_Missense_Mutation_p.K136E|SEPT7_ENST00000469679.2_Missense_Mutation_p.K136E|SEPT7_ENST00000350320.6_Missense_Mutation_p.K136E|SEPT7_ENST00000475109.1_3'UTR			Q16181	SEPT7_HUMAN	septin 7	137					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)	14						CATTGATAGTAAATTTGAGGA	0.393000													5	24					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234378054	234378054	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:234378054T>C	ENST00000264057.2	+	30	3605	c.3593T>C	c.(3592-3594)aTc>aCc	p.I1198T	DGKD_ENST00000409813.3_Missense_Mutation_p.I1154T	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	1198	SAM.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	ATGAAGAGGATCCTGTGTGGC	0.662000													3	16					0	0	1	0	0
C9orf9	11092	broad.mit.edu	37	9	135759426	135759426	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:135759426A>G	ENST00000372136.3	+	2	539	c.92A>G	c.(91-93)cAc>cGc	p.H31R	C9orf9_ENST00000356311.5_Missense_Mutation_p.H31R|C9orf9_ENST00000350499.6_Missense_Mutation_p.H31R			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	31								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		GCTCTGGAGCACTGCAGGGAG	0.612000													19	69					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21721940	21721940	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:21721940T>C	ENST00000261195.2	-	5	936	c.682A>G	c.(682-684)Aac>Gac	p.N228D		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	228					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TTGTCAATGTTAAACTGTTAG	0.433000													31	81					0	0	1	0	0
CNDP1	84735	broad.mit.edu	37	18	72238438	72238438	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:72238438G>T	ENST00000582365.1	+	6	711	c.645G>T	c.(643-645)caG>caT	p.Q215H	CNDP1_ENST00000358821.3_Missense_Mutation_p.Q258H			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	258					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GCAGAGACCAGGATTTTCACT	0.403000													22	84					2.41591e-17	2.54096e-17	1	1	0
MRE11A	4361	broad.mit.edu	37	11	94224061	94224061	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:94224061C>T	ENST00000323929.3	-	3	313	c.91G>A	c.(91-93)Gtc>Atc	p.V31I	MRE11A_ENST00000536144.1_5'UTR|MRE11A_ENST00000407439.3_Missense_Mutation_p.V34I|MRE11A_ENST00000540013.1_Missense_Mutation_p.V31I|MRE11A_ENST00000323977.3_Missense_Mutation_p.V31I|MRE11A_ENST00000393241.4_Missense_Mutation_p.V31I	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	31				V -> A (in Ref. 1; AAC78721).	DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				TTTCCTCTGACTGCATCTTTC	0.313000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				19	54					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155219642	155219642	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155219642C>T	ENST00000357232.3	-	18	4458	c.4459G>A	c.(4459-4461)Gtg>Atg	p.V1487M		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1487	Cadherin 13.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCTTCTCTCACAGAGGACTGG	0.463000													50	145					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6704170	6704170	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:6704170C>T	ENST00000338694.2	-	7	1074	c.945G>A	c.(943-945)acG>acA	p.T315T	TEKT1_ENST00000535086.1_Silent_p.T169T	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	315					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				TCTCCAAGCGCGTATGAGCCA	0.502000											OREG0024124	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	179					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147781675	147781675	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:147781675C>T	ENST00000340253.5	+	4	561	c.393C>T	c.(391-393)gtC>gtT	p.V131V	FBXO38_ENST00000394370.3_Silent_p.V131V|FBXO38_ENST00000509699.2_3'UTR|FBXO38_ENST00000513826.1_Silent_p.V131V|FBXO38_ENST00000296701.6_Silent_p.V131V			Q6PIJ6	FBX38_HUMAN	F-box protein 38	131						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCAGGAGTCCTAGAAGCTT	0.443000													13	168					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185986616	185986616	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:185986616G>A	ENST00000265022.3	-	12	1629	c.1090C>T	c.(1090-1092)Cgg>Tgg	p.R364W	DGKG_ENST00000544847.1_Intron|DGKG_ENST00000382164.4_Intron|DGKG_ENST00000344484.4_Missense_Mutation_p.R364W	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	364					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	ACGCAGTGCCGCGCGGTGACA	0.607000													6	33					0	0	1	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249106318	249106318	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:249106318G>A	ENST00000366472.5	-	7	2192	c.963C>T	c.(961-963)agC>agT	p.S321S	SH3BP5L_ENST00000475978.1_5'UTR|SH3BP5L_ENST00000411742.2_Silent_p.S289S	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	321										endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CGGGCCCCAGGCTGCTGCCCT	0.716000													4	52					0	0	1	0	0
KIF18A	81930	broad.mit.edu	37	11	28104410	28104410	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:28104410T>C	ENST00000263181.6	-	9	1545	c.1255A>G	c.(1255-1257)Atc>Gtc	p.I419V		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	419					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						TACCTTTCGATTTCTTTTTCC	0.249000													11	29					0	0	1	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38411462	38411462	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:38411462C>T	ENST00000377694.1	-	4	794	c.772G>A	c.(772-774)Gtg>Atg	p.V258M		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	258	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		AGAACCGTCACTGTGCTGTGG	0.498000													15	61					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21829058	21829058	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21829058C>T	ENST00000216297.2	-	17	2341	c.2003G>A	c.(2002-2004)cGc>cAc	p.R668H		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	668					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AATATTTGGGCGAATGTATAG	0.423000													28	64					0	0	1	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66988980	66988980	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:66988980G>A	ENST00000276570.5	+	4	492	c.205G>A	c.(205-207)Gca>Aca	p.A69T	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	69	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CAACGCCCACGCAATACTTAC	0.428000													5	340					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28122739	28122739	+	Translation_Start_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:28122739T>C	ENST00000395868.3	-	0	241				PTHLH_ENST00000545234.1_Intron|PTHLH_ENST00000535992.1_Intron|PTHLH_ENST00000201015.4_Intron|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000395872.1_Intron|PTHLH_ENST00000354417.3_Intron	NM_198964.1	NP_945315.1	P12272	PTHR_HUMAN	parathyroid hormone-like hormone						activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					AAAATGGTTTTATATATGCAT	0.403000													30	124					0	0	1	0	0
FCER1A	2205	broad.mit.edu	37	1	159275912	159275912	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:159275912T>C	ENST00000368115.1	+	5	565	c.466T>C	c.(466-468)Tat>Cat	p.Y156H	FCER1A_ENST00000368114.1_Missense_Mutation_p.Y123H	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	156	Ig-like 2.					integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CAAGTACTGGTATGAGAACCA	0.498000													33	84					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33841032	33841032	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:33841032T>C	ENST00000257118.5	-	1	162	c.109A>G	c.(109-111)Agt>Ggt	p.S37G	PHC2_ENST00000419414.2_Missense_Mutation_p.S37G|PHC2_ENST00000431992.1_Missense_Mutation_p.S37G|PHC2_ENST00000373416.1_5'UTR	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	37	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGgcggccacttccaccactg	0.567000													31	81					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991509	70991509	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:70991509G>T	ENST00000256389.3	-	2	360	c.116C>A	c.(115-117)gCt>gAt	p.A39D	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TCTGTCTAGAGCAGAAGAGAA	0.542000													8	186					1.06961e-07	1.09985e-07	1	1	0
ASH1L	55870	broad.mit.edu	37	1	155313465	155313465	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:155313465G>A	ENST00000368346.3	-	23	8704	c.8065C>T	c.(8065-8067)Cga>Tga	p.R2689*	ASH1L_ENST00000392403.3_Nonsense_Mutation_p.R2684*			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2689	BAH.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GATAACAGTCGATAGGACTGA	0.473000													18	55					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84495409	84495409	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84495409C>T	ENST00000416219.2	+	26	2747	c.2658C>T	c.(2656-2658)tgC>tgT	p.C886C	RP11-517C16.2_ENST00000565700.1_RNA|ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Silent_p.C857C			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	857					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						CCTTGACCTGCCGCTCTCAGG	0.597000													56	137					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210558304	210558304	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:210558304A>G	ENST00000360351.4	+	7	1916	c.1410A>G	c.(1408-1410)atA>atG	p.I470M	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.I466M	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	470					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ATGAAGAAATAGGCATAATTC	0.428000													26	65					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096565	73096565	+	Silent	SNP	C	C	T	rs61750012		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:73096565C>T	ENST00000450736.2	+	4	1222	c.807C>T	c.(805-807)gaC>gaT	p.D269D	SLC16A5_ENST00000580123.1_Silent_p.D269D|SLC16A5_ENST00000329783.4_Silent_p.D269D|SLC16A5_ENST00000538213.2_Silent_p.D309D			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	269					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	ACAGCGTGGACGAGCAGCAGG	0.612000													8	49					0	0	1	0	0
C20orf195	79025	broad.mit.edu	37	20	62187126	62187126	+	Missense_Mutation	SNP	C	C	T	rs148340283		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62187126C>T	ENST00000370098.3	+	2	202	c.110C>T	c.(109-111)gCg>gTg	p.A37V	C20orf195_ENST00000370097.1_Missense_Mutation_p.A37V	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	37										large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GAACCAGAGGCGTGGAAGACC	0.642000													12	58					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169847374	169847374	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:169847374T>C	ENST00000263817.6	-	9	969	c.845A>G	c.(844-846)gAt>gGt	p.D282G		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	282	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AATGACTTCATCAGCCACCAC	0.398000													29	285					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9703965	9703965	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:9703965T>C	ENST00000296003.4	+	3	445	c.323T>C	c.(322-324)gTa>gCa	p.V108A	MTMR14_ENST00000353332.5_Missense_Mutation_p.V108A|MTMR14_ENST00000420925.1_Intron|MTMR14_ENST00000351233.5_Missense_Mutation_p.V108A	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	108						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					GAGAGTACCGTACAGGTGAGC	0.507000													22	56					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139395187	139395187	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139395187G>A	ENST00000277541.6	-	31	5826	c.5751C>T	c.(5749-5751)ggC>ggT	p.G1917G		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1917					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGGCTGGCGCCCTGGTAGA	0.692000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			51	152					0	0	1	0	0
MB21D2	151963	broad.mit.edu	37	3	192516295	192516295	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:192516295G>T	ENST00000392452.2	-	2	1676	c.1356C>A	c.(1354-1356)gaC>gaA	p.D452E		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	452										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						TTGCCAAACGGTCATCAGGCT	0.552000													46	139					6.68952e-21	7.05551e-21	1	1	0
FAM24B	196792	broad.mit.edu	37	10	124608784	124608784	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:124608784G>A	ENST00000368898.3	-	4	554	c.264C>T	c.(262-264)tgC>tgT	p.C88C	FAM24B_ENST00000462859.1_5'UTR|CUZD1_ENST00000368904.1_5'UTR|CUZD1_ENST00000545804.1_Intron|FAM24B_ENST00000368896.1_Silent_p.C88C	NM_152644.2	NP_689857.2	Q8N5W8	FA24B_HUMAN	family with sequence similarity 24, member B	88						extracellular region				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.136)|COAD - Colon adenocarcinoma(40;0.141)		CATTTATGTCGCAACAGCAAG	0.448000													28	73					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1893175	1893175	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:1893175G>A	ENST00000399161.2	-	16	3105	c.2358C>T	c.(2356-2358)tgC>tgT	p.C786C	MYT1L_ENST00000428368.2_Silent_p.C784C	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	786					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGATGGGGCAGCAGCTGTCCC	0.612000													26	82					0	0	1	0	0
CENPU	79682	broad.mit.edu	37	4	185650087	185650087	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:185650087T>C	ENST00000281453.5	-	3	269	c.199A>G	c.(199-201)Act>Gct	p.T67A	MLF1IP_ENST00000541971.1_Missense_Mutation_p.T67A	NM_024629.3	NP_078905.2	Q71F23	CENPU_HUMAN		67					CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|stomach(1)	13		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		GTCTCATAAGTTTCTTCATCT	0.353000													13	72					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25004174	25004174	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:25004174C>T	ENST00000537502.1	-	2	2017	c.486G>A	c.(484-486)gtG>gtA	p.V162V	ACSS1_ENST00000323482.4_Silent_p.V245V|ACSS1_ENST00000542618.1_Silent_p.V124V|ACSS1_ENST00000432802.2_Silent_p.V245V			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	245					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGACATGCTGCACGGTGGGGC	0.577000													8	35					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58569540	58569540	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:58569540T>C	ENST00000348616.4	+	11	1962	c.1662T>C	c.(1660-1662)aaT>aaC	p.N554N	CDH26_ENST00000244047.5_Silent_p.N554N|CDH26_ENST00000497614.1_3'UTR	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	554					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TGGGGAGAAATTGGGGTGAGT	0.428000													14	51					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38209791	38209791	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:38209791A>G	ENST00000394126.1	-	1	554	c.136T>C	c.(136-138)Tac>Cac	p.Y46H	MED24_ENST00000394127.2_Missense_Mutation_p.Y21H|MED24_ENST00000356271.3_Missense_Mutation_p.Y21H|MED24_ENST00000501516.3_Missense_Mutation_p.Y21H|MED24_ENST00000479829.1_5'UTR|MED24_ENST00000394128.2_Missense_Mutation_p.Y21H			O75448	MED24_HUMAN	mediator complex subunit 24	21					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					GCCCATTGGTAGTCACTCCAG	0.502000													69	203					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138160345	138160345	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:138160345G>A	ENST00000302763.7	+	6	805	c.715G>A	c.(715-717)Gcc>Acc	p.A239T	CTNNA1_ENST00000355078.5_Missense_Mutation_p.A136T|CTNNA1_ENST00000518825.1_Missense_Mutation_p.A239T	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	239					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGCCTATAAGGCCAACAGGGA	0.567000													4	102					0	0	1	0	0
ATP1B2	482	broad.mit.edu	37	17	7558890	7558890	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7558890G>A	ENST00000250111.4	+	6	1062	c.655G>A	c.(655-657)Gcc>Acc	p.A219T		NM_001678.3	NP_001669.3	P14415	AT1B2_HUMAN	ATPase, Na+/K+ transporting, beta 2 polypeptide	219					ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|pancreas(1)	10		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		CATGTTCCCCGCCAACGGCAA	0.587000													29	68					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32235180	32235180	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:32235180C>T	ENST00000357033.4	-	44	6497	c.6290_splice	c.e44-1	p.G2097_splice	DMD_ENST00000378677.2_Splice_Site_p.G2093_splice	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2097					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGTCAAATCGCCTGCAGGTAA	0.333000													9	7					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108562670	108562670	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:108562670G>A	ENST00000526794.1	+	8	1075	c.1043G>A	c.(1042-1044)cGa>cAa	p.R348Q	DDX10_ENST00000322536.3_Missense_Mutation_p.R348Q			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	348	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		CTCCATGGTCGACAGCAGCAA	0.468000			T	NUP98	AML*								37	90					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448901	155448901	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:155448901G>A	ENST00000368346.3	-	3	4399	c.3760C>T	c.(3760-3762)Cgc>Tgc	p.R1254C	ASH1L_ENST00000392403.3_Missense_Mutation_p.R1254C			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1254					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGATTCCTGCGCTTACATTTG	0.393000													55	171					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43623734	43623734	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:43623734A>G	ENST00000372806.3	+	6	624	c.529A>G	c.(529-531)Acc>Gcc	p.T177A	STK4_ENST00000499879.2_Missense_Mutation_p.T122A|STK4_ENST00000396731.4_Missense_Mutation_p.T177A|STK4_ENST00000372801.1_Missense_Mutation_p.T177A	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	177	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				ATTTTAGGATACCATGGCCAA	0.398000													40	116					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30700428	30700428	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:30700428T>C	ENST00000256246.2	-	1	6180	c.6106A>G	c.(6106-6108)Aca>Gca	p.T2036A		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2036										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTTCTTCTGTGATAAAAATA	0.313000													7	26					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21042591	21042591	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:21042591A>G	ENST00000261383.3	-	37	5214	c.5215T>C	c.(5215-5217)Ttt>Ctt	p.F1739L	DNAH3_ENST00000415178.1_Missense_Mutation_p.F1739L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1739	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCCACAGCAAACTCCTCCATC	0.493000													5	77					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30694437	30694437	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:30694437A>G	ENST00000256246.2	-	3	8288	c.8214T>C	c.(8212-8214)ccT>ccC	p.P2738P		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2738										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AATTAGAAGCAGGTATTTGAG	0.398000													29	135					0	0	1	0	0
RAD51D	5892	broad.mit.edu	37	17	33430517	33430517	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:33430517A>T	ENST00000345365.6	-	7	878	c.623T>A	c.(622-624)gTc>gAc	p.V208D	RAD51D_ENST00000460118.2_Missense_Mutation_p.V89D|RAD51D_ENST00000360276.3_Missense_Mutation_p.V163D|RAD51D_ENST00000394589.4_Missense_Mutation_p.V208D|RAD51D_ENST00000590380.1_5'UTR|RAD51D_ENST00000590016.1_Missense_Mutation_p.V228D|RAD51L3-RFFL_ENST00000593039.1_Missense_Mutation_p.V49D|RAD51D_ENST00000335858.7_Missense_Mutation_p.V96D	NM_002878.3	NP_002869.3	O75771	RA51D_HUMAN	RAD51 paralog D	208					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						CACCGCAGTGACCGAGTCCAC	0.567000								Direct reversal of damage					15	59					0	0	1	0	0
DDX21	9188	broad.mit.edu	37	10	70741317	70741317	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:70741317G>A	ENST00000354185.4	+	14	2160	c.2062G>A	c.(2062-2064)Gca>Aca	p.A688T		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	688						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						TGTACCTACCGCATCAGTAAC	0.318000													14	51					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2019090	2019090	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:2019090T>C	ENST00000382722.5	-	4	830	c.468A>G	c.(466-468)gaA>gaG	p.E156E	CACNA2D4_ENST00000585708.1_Silent_p.E92E|CACNA2D4_ENST00000588077.1_Silent_p.E92E|CACNA2D4_ENST00000585732.1_Silent_p.E156E|CACNA2D4_ENST00000586184.1_Silent_p.E156E|CACNA2D4_ENST00000587995.1_Silent_p.E156E	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	156						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ATTCATTGAATTCGTGGTTCA	0.587000													5	37					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138196092	138196092	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:138196092C>T	ENST00000237289.4	+	3	472	c.406C>T	c.(406-408)Cgc>Tgc	p.R136C		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	136	OTU.|TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.R136fs*3(2)|p.R136fs*4(1)|p.W113_F140del(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AACAGACACACGCAACTTTAA	0.488000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								28	106					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19666640	19666640	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:19666640G>A	ENST00000284885.3	-	21	2466	c.2433C>T	c.(2431-2433)ggC>ggT	p.G811G		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	811	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						CGAGAGATGCGCCGCAGAGCA	0.567000													33	113					0	0	1	0	0
GBA2	57704	broad.mit.edu	37	9	35737315	35737315	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35737315G>A	ENST00000378103.3	-	17	3158	c.2635C>T	c.(2635-2637)Cgg>Tgg	p.R879W	GBA2_ENST00000378088.1_3'UTR|GBA2_ENST00000378094.4_3'UTR|GBA2_ENST00000545786.1_Missense_Mutation_p.R885W	NM_020944.2	NP_065995.1	Q9HCG7	GBA2_HUMAN	glucosidase, beta (bile acid) 2	879					bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			NS(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(4)|skin(3)	21	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTCAGTGGCCGCATGTAGGCC	0.602000													19	73					0	0	1	0	0
PNMA3	29944	broad.mit.edu	37	X	152226134	152226134	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:152226134G>A	ENST00000447306.1	+	2	1058	c.722G>A	c.(721-723)gGa>gAa	p.G241E	PNMA3_ENST00000370265.4_Missense_Mutation_p.G241E|PNMA3_ENST00000370264.4_Missense_Mutation_p.G241E	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	241					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					caggtgttcggacctgtggag	0.552000													80	87					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11942804	11942804	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11942804T>C	ENST00000304060.5	+	4	977	c.813T>C	c.(811-813)taT>taC	p.Y271Y		NM_152357.2	NP_689570.2	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(9)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CCAGATCCTATCGTAGACATG	0.403000													4	81					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43154058	43154058	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:43154058T>C	ENST00000252050.4	+	4	1200	c.1116T>C	c.(1114-1116)cgT>cgC	p.R372R	CUL9_ENST00000372647.2_Silent_p.R372R|CUL9_ENST00000354495.3_Silent_p.R372R	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	372					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						TCTCCAGCCGTAGTGGCTATG	0.572000													35	112					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236622	140236622	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140236622T>C	ENST00000307360.5	+	1	989	c.989T>C	c.(988-990)gTt>gCt	p.V330A	PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.V330A|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCTATGGTTGGTCACTGC	0.408000													25	117					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53907751	53907751	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:53907751T>A	ENST00000471389.1	+	5	1171	c.949T>A	c.(949-951)Ttt>Att	p.F317I	FTO_ENST00000394647.3_Missense_Mutation_p.F21I	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	317	Alpha-ketoglutarate binding.|Fe2OG dioxygenase domain.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						ACAACCTCGGTTTAGTTCCAC	0.403000													6	89					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53331006	53331006	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:53331006G>C	ENST00000566029.1	+	30	5858	c.5649G>C	c.(5647-5649)ttG>ttC	p.L1883F	CHD9_ENST00000564845.1_Missense_Mutation_p.L1883F|CHD9_ENST00000447540.1_Missense_Mutation_p.L1883F|CHD9_ENST00000398510.3_Missense_Mutation_p.L1883F			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1883					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				ATGATAGTTTGGAAAAATATT	0.378000													32	113					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825605	4825605	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:4825605C>T	ENST00000380382.1	-	1	242	c.243G>A	c.(241-243)gtG>gtA	p.V81V	OR52R1_ENST00000356069.2_Silent_p.V2V|MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGAAGCCAGCACCATGGACT	0.458000													12	74					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957371	12957371	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:12957371G>A	ENST00000276297.4	-	9	2884	c.2475C>T	c.(2473-2475)ggC>ggT	p.G825G	DLC1_ENST00000512044.2_Silent_p.G422G|DLC1_ENST00000520226.1_Silent_p.G314G|DLC1_ENST00000358919.2_Silent_p.G388G	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	825					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GGGAGAAACTGCCATTGGTGA	0.557000													13	243					0	0	1	0	0
ALAS2	212	broad.mit.edu	37	X	55041391	55041391	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:55041391A>G	ENST00000330807.5	-	9	1363	c.1226T>C	c.(1225-1227)aTg>aCg	p.M409T	ALAS2_ENST00000396198.3_Missense_Mutation_p.M396T|ALAS2_ENST00000335854.4_Missense_Mutation_p.M372T|ALAS2_ENST00000498636.1_5'UTR	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	409					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	GGAGCGCACCATGTCCACCAA	0.542000													10	14					0	0	1	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16053852	16053852	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16053852C>T	ENST00000375799.3	+	9	1512	c.1285C>T	c.(1285-1287)Cgt>Tgt	p.R429C	RP11-288I21.1_ENST00000453804.1_RNA|PLEKHM2_ENST00000375793.2_Missense_Mutation_p.R409C	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	429					Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		CTGGTGCTCCCGTGCTGAGCC	0.652000													6	13					0	0	1	0	0
ENTPD7	57089	broad.mit.edu	37	10	101455822	101455822	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:101455822A>G	ENST00000370489.4	+	9	1131	c.953A>G	c.(952-954)aAc>aGc	p.N318S		NM_020354.3	NP_065087.1	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase 7	318						cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		TTCGGAGGCAACTTTGCCCGG	0.453000													7	101					0	0	1	0	0
PBXIP1	57326	broad.mit.edu	37	1	154924305	154924305	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:154924305A>G	ENST00000368463.3	-	3	215	c.144T>C	c.(142-144)gaT>gaC	p.D48D	PBXIP1_ENST00000368460.3_Silent_p.D48D|PBXIP1_ENST00000539880.1_Intron|PBXIP1_ENST00000368465.1_Silent_p.D19D|PBXIP1_ENST00000542459.1_Intron|PBXIP1_ENST00000498553.1_Intron	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	48					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ATTCTTTCCCATCTGTCTTGG	0.562000													82	210					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34611575	34611575	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:34611575A>T	ENST00000373973.3	+	11	1494	c.1321A>T	c.(1321-1323)Atc>Ttc	p.I441F	CNBD2_ENST00000538900.1_Intron|CNBD2_ENST00000349339.1_Missense_Mutation_p.I437F					cyclic nucleotide binding domain containing 2																		ACGACCCTTGATCCTGATGAG	0.458000													13	108					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110783052	110783052	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:110783052A>G	ENST00000395494.2	+	17	3089		c.e17-1		ATP2A2_ENST00000308664.6_Splice_Site|ATP2A2_ENST00000539276.2_Splice_Site			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2						ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						ATTTTCTTGCAGAGTCATTTC	0.483000													51	200					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81201475	81201475	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:81201475C>T	ENST00000394685.3	+	14	2044	c.1625C>T	c.(1624-1626)aCg>aTg	p.T542M	RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000220244.3_Missense_Mutation_p.T542M|RP11-351M8.1_ENST00000560560.1_Intron|KIAA1199_ENST00000356249.5_Missense_Mutation_p.T542M			Q8WUJ3	K1199_HUMAN	KIAA1199	542										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TTGGAGGGCACGGAGCTGAAG	0.552000													10	46					0	0	1	0	0
SIVA1	10572	broad.mit.edu	37	14	105222045	105222045	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:105222045A>G	ENST00000329967.6	+	2	299	c.197A>G	c.(196-198)cAc>cGc	p.H66R	SIVA1_ENST00000347067.5_Intron	NM_006427.3	NP_006418.2	O15304	SIVA_HUMAN	SIVA1, apoptosis-inducing factor	66					activation of caspase activity by cytochrome c|activation-induced cell death of T cells|apoptosis|induction of apoptosis|interspecies interaction between organisms|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity	cytoplasm|mitochondrion|nucleoplasm|nucleus	caspase activator activity|CD27 receptor binding|metal ion binding|viral receptor activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3		all_cancers(154;0.14)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.173)		GCCGTCGTTCACCTGCCAGAG	0.627000													27	70					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45412817	45412817	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:45412817G>A	ENST00000558996.1	-	4	446	c.392C>T	c.(391-393)gCg>gTg	p.A131V	DUOXA1_ENST00000559014.1_Missense_Mutation_p.A176V|DUOXA1_ENST00000560572.1_Missense_Mutation_p.A176V|DUOXA1_ENST00000558422.1_Missense_Mutation_p.A131V|DUOXA1_ENST00000267803.4_Missense_Mutation_p.A176V|DUOXA1_ENST00000430224.2_Missense_Mutation_p.A131V	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	176					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		GTAGTGTCCCGCCAGGCGGTA	0.577000													59	98					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42357119	42357119	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:42357119G>A	ENST00000554171.1	+	5	3723	c.1291G>A	c.(1291-1293)Gca>Aca	p.A431T	LRFN5_ENST00000554120.1_Missense_Mutation_p.A431T|LRFN5_ENST00000298119.4_Missense_Mutation_p.A431T			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	431	Fibronectin type-III.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ATCATCAACGGCACTACTTAA	0.353000										HNSCC(30;0.082)			18	41					0	0	1	0	0
WASL	8976	broad.mit.edu	37	7	123346845	123346845	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:123346845A>G	ENST00000223023.4	-	3	620	c.288T>C	c.(286-288)aaT>aaC	p.N96N		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	96	WH1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATACAAAGTTATTGTATAGCT	0.289000													14	41					0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16640449	16640449	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:16640449T>C	ENST00000306999.2	-	10	1506	c.1263A>G	c.(1261-1263)gaA>gaG	p.E421E		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	421						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CAGCTTCGCTTTCAAGAGATT	0.488000													25	54					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124094399	124094399	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:124094399A>G	ENST00000368994.2	+	14	1422	c.1171A>G	c.(1171-1173)Aat>Gat	p.N391D	BTBD16_ENST00000260723.4_Missense_Mutation_p.N390D|BTBD16_ENST00000495370.2_3'UTR			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	390										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				AATTTAGGAGAATACAACTTA	0.383000													4	87					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332448	71332448	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:71332448T>C	ENST00000242462.4	-	2	381	c.352A>G	c.(352-354)Aag>Gag	p.K118E		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	118	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						TTGGTGAGCTTCGCGTCGTCT	0.627000													19	63					0	0	1	0	0
MKRN1	23608	broad.mit.edu	37	7	140171758	140171758	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:140171758T>C	ENST00000255977.2	-	2	463	c.239A>G	c.(238-240)gAc>gGc	p.D80G	MKRN1_ENST00000437223.2_5'UTR|MKRN1_ENST00000443720.2_Missense_Mutation_p.D80G|MKRN1_ENST00000480552.1_Missense_Mutation_p.D16G|MKRN1_ENST00000481705.1_5'UTR|MKRN1_ENST00000474576.1_Missense_Mutation_p.D16G	NM_013446.3	NP_038474.2	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1	80							ligase activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	16	Melanoma(164;0.00956)					GTCAGAGAGGTCATGCGAGTA	0.408000													23	80					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24722076	24722076	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:24722076A>G	ENST00000376454.3	+	4	736	c.706A>G	c.(706-708)Atc>Gtc	p.I236V	KIAA1217_ENST00000458595.1_Missense_Mutation_p.I236V|KIAA1217_ENST00000376452.3_Missense_Mutation_p.I236V|KIAA1217_ENST00000430453.2_Missense_Mutation_p.I157V|KIAA1217_ENST00000376462.1_Missense_Mutation_p.I156V	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	236					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CGCCATTTACATCAAAGATGA	0.393000													24	53					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43157155	43157155	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:43157155T>C	ENST00000522175.2	+	0	697							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATCAGCAAGTATAGTTAGTC	0.328000													6	88					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155720164	155720164	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155720164G>A	ENST00000510397.1	+	4	1029	c.850G>A	c.(850-852)Gca>Aca	p.A284T	RBM46_ENST00000281722.3_Missense_Mutation_p.A284T|RBM46_ENST00000514866.1_Missense_Mutation_p.A284T	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	284	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				CCGAGAAGATGCAGTGGCTGC	0.363000													12	55					0	0	1	0	0
TMEM259	91304	broad.mit.edu	37	19	1012124	1012124	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1012124C>A	ENST00000356663.3	-	5	903	c.782G>T	c.(781-783)gGc>gTc	p.G261V	TMEM259_ENST00000333175.5_Missense_Mutation_p.G261V	NM_001033026.1	NP_001028198.1			transmembrane protein 259																		GTCATCGTAGCCCAGGAACTC	0.692000													6	18					0.0215528	0.0216729	1	1	0
IRF2BPL	64207	broad.mit.edu	37	14	77494128	77494128	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:77494128G>A	ENST00000238647.3	-	1	906	c.8C>T	c.(7-9)gCg>gTg	p.A3V		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	3						nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						CACCTGCGCCGCCGACATGAT	0.697000													15	22					0	0	1	0	0
PCYT2	5833	broad.mit.edu	37	17	79862964	79862964	+	Missense_Mutation	SNP	C	C	T	rs142625466		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:79862964C>T	ENST00000538936.2	-	12	1144	c.1036G>A	c.(1036-1038)Gtc>Atc	p.V346I	PCYT2_ENST00000571105.1_Missense_Mutation_p.V324I|PCYT2_ENST00000570388.1_Missense_Mutation_p.V268I|PCYT2_ENST00000570391.1_Missense_Mutation_p.V314I|PCYT2_ENST00000331285.3_Missense_Mutation_p.V268I|PCYT2_ENST00000538721.2_Missense_Mutation_p.V364I	NM_001256435.1|NM_002861.3	NP_001243364.1|NP_002852.1	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	346	Catalytic 2 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity			breast(2)|endometrium(1)|lung(4)|ovary(1)	8	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ATCCGCTGGACGATGAGGTCT	0.632000													9	21					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54965653	54965653	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54965653C>A	ENST00000326764.5	+	6	950	c.471C>A	c.(469-471)ccC>ccA	p.P157P	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	120							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		ACCAGGCTCCCCCTCAGCAGC	0.667000													22	53					2.79863e-10	2.90221e-10	1	1	0
KIFC1	3833	broad.mit.edu	37	6	33371120	33371120	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:33371120C>T	ENST00000428849.2	+	4	730	c.280C>T	c.(280-282)Cgg>Tgg	p.R94W	KIFC1_ENST00000486695.1_3'UTR	NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	94					blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						GACAGGACCCCGGTGTTCCAC	0.493000													37	107					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184834	19184834	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:19184834G>A	ENST00000275461.3	-	1	210	c.152C>T	c.(151-153)cCc>cTc	p.P51L	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	51					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CATCCTCCTGGGTCTTCCCTC	0.662000													16	46					0	0	1	0	0
ALG6	29929	broad.mit.edu	37	1	63836712	63836712	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:63836712T>C	ENST00000371108.4	+	2	369	c.64T>C	c.(64-66)Tct>Cct	p.S22P	ALG6_ENST00000263440.4_Missense_Mutation_p.S22P	NM_013339.3	NP_037471.2	Q9Y672	ALG6_HUMAN	ALG6, alpha-1,3-glucosyltransferase	22					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						ATGGACAGTGTCTCTTAATTC	0.333000													36	87					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47456400	47456400	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:47456400G>A	ENST00000265565.5	-	20	3635	c.3223C>T	c.(3223-3225)Ccc>Tcc	p.P1075S	SCAP_ENST00000545718.1_Missense_Mutation_p.P682S|SCAP_ENST00000441517.2_Missense_Mutation_p.P819S	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	1075	Interaction with SREBF2 (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		TGTGCACAGGGCACTGTGTGG	0.602000													28	84					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25325857	25325857	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25325857A>G	ENST00000330560.3	+	6	1140	c.663A>G	c.(661-663)gtA>gtG	p.V221V	CDCA2_ENST00000380665.3_Silent_p.V206V	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	221					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AAGGAAAAGTAATTGGTCTCC	0.423000													41	91					0	0	1	0	0
C5orf66	100996485	broad.mit.edu	37	5	134679129	134679129	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:134679129T>C	ENST00000432382.3	+	6	1233	c.411T>C	c.(409-411)agT>agC	p.S137S	CTC-203F4.1_ENST00000555438.1_Intron|H2AFY_ENST00000511689.1_Intron|H2AFY_ENST00000423969.2_Intron|H2AFY_ENST00000512507.1_Intron|H2AFY_ENST00000510038.1_Intron|H2AFY_ENST00000304332.4_Intron|H2AFY_ENST00000312469.4_Intron	NM_001277348.1	NP_001264277.1																					CAGCAGCTAGTGGTGCGGGGA	0.532000													8	169					0	0	1	0	0
ZBTB47	92999	broad.mit.edu	37	3	42703044	42703044	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:42703044G>A	ENST00000457842.3	+	3	1822	c.413G>A	c.(412-414)gGc>gAc	p.G138D	ZBTB47_ENST00000232974.6_Missense_Mutation_p.G514D|ZBTB47_ENST00000505904.1_Missense_Mutation_p.G60D	NM_145166.3	NP_660149.2	Q9UFB7	ZBT47_HUMAN	zinc finger and BTB domain containing 47	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(3)|ovary(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.216)		ATTGTGCACGGCTACGCAGAG	0.517000													17	58					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47243541	47243541	+	Silent	SNP	C	C	T	rs142560351	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:47243541C>T	ENST00000300404.2	+	9	1259	c.1200C>T	c.(1198-1200)gaC>gaT	p.D400D	B4GALNT2_ENST00000393354.2_Silent_p.D340D|B4GALNT2_ENST00000504681.1_Silent_p.D314D	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	400					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TCTGGGTGGACGATGATTTTC	0.498000													21	60					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604505	179604505	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179604505T>C	ENST00000589042.1	-	48	13679	c.13455A>G	c.(13453-13455)atA>atG	p.I4485M	TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I4122M|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.I4168M|TTN_ENST00000359218.5_Missense_Mutation_p.I4247M|TTN_ENST00000342175.6_Missense_Mutation_p.I4314M|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4168	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAGGATGTCTATTTCCTCAT	0.388000													62	218					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	196792280	196792280	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:196792280C>G	ENST00000346964.2	-	23	2528	c.2339G>C	c.(2338-2340)aGa>aCa	p.R780T	DLG1_ENST00000314062.3_Missense_Mutation_p.R707T|DLG1_ENST00000448528.2_Missense_Mutation_p.R758T|DLG1_ENST00000452595.1_Missense_Mutation_p.R642T|DLG1_ENST00000450955.1_Missense_Mutation_p.R747T|DLG1_ENST00000419354.1_Missense_Mutation_p.R758T|DLG1_ENST00000422288.1_Missense_Mutation_p.R707T|DLG1_ENST00000443183.1_Missense_Mutation_p.R654T|DLG1_ENST00000392382.2_Missense_Mutation_p.R725T|DLG1_ENST00000357674.4_Missense_Mutation_p.R747T	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	758	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		ATGATAATCTCTTCCATCTAC	0.313000													29	60					0	0	1	0	0
AATF	26574	broad.mit.edu	37	17	35388942	35388942	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:35388942A>G	ENST00000225402.5	+	11	1830	c.1579A>G	c.(1579-1581)Atg>Gtg	p.M527V		NM_012138.3	NP_036270.1	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	527					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)	18		Breast(25;0.00607)				ACTGAGTTTCATGGCACCTAT	0.398000													36	111					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159162460	159162460	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:159162460T>C	ENST00000368125.4	+	3	479	c.322T>C	c.(322-324)Tac>Cac	p.Y108H	CADM3_ENST00000368124.4_Missense_Mutation_p.Y142H	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	108	Ig-like V-type.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					CGAGGGCGAGTACACCTGCTC	0.557000													37	104					0	0	1	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49327791	49327791	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:49327791A>G	ENST00000559471.1	-	3	531	c.268T>C	c.(268-270)Tac>Cac	p.Y90H	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.Y90H	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	90										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						TAGGCAAAGTATGGTCCAGTA	0.403000													37	117					0	0	1	0	0
RPS23	6228	broad.mit.edu	37	5	81571973	81571973	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:81571973A>G	ENST00000296674.8	-	4	640	c.387T>C	c.(385-387)tcT>tcC	p.S129S	RPS23_ENST00000512493.1_Intron|RPS23_ENST00000510019.1_Intron|RPS23_ENST00000507980.1_3'UTR|RPS23_ENST00000503605.1_Intron|RPS23_ENST00000510210.1_Intron|ATG10_ENST00000514253.2_3'UTR	NM_001025.4	NP_001016.1	P62266	RS23_HUMAN	ribosomal protein S23	129					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome			prostate(1)	1		Lung NSC(167;0.0025)|all_lung(232;0.00278)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-42)|Epithelial(54;8.38e-37)|all cancers(79;1.42e-31)		GGGCCAAAAGAGAAACATTGG	0.368000													15	49					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10247831	10247831	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10247831A>G	ENST00000340748.4	-	36	4606	c.4371T>C	c.(4369-4371)taT>taC	p.Y1457Y	DNMT1_ENST00000359526.4_Silent_p.Y1473Y|DNMT1_ENST00000540357.1_Silent_p.Y1457Y			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	1457	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CATGGTGGGTATACCGCAGCT	0.652000													4	12					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48456740	48456740	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:48456740A>G	ENST00000358536.4	-	20	4080	c.3811T>C	c.(3811-3813)Tgc>Cgc	p.C1271R	PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000465117.1_5'UTR|PLXNB1_ENST00000358459.4_Missense_Mutation_p.C1088R|PLXNB1_ENST00000296440.6_Missense_Mutation_p.C1271R|PLXNB1_ENST00000456774.1_Missense_Mutation_p.C1088R	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1271	IPT/TIG 3.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCACGGACGCATATCTCACGT	0.582000													9	37					0	0	1	0	0
ABHD8	79575	broad.mit.edu	37	19	17412082	17412082	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17412082G>A	ENST00000247706.3	-	2	583	c.344C>T	c.(343-345)gCc>gTc	p.A115V	MRPL34_ENST00000595444.1_Intron|MRPL34_ENST00000600434.1_Intron	NM_024527.4	NP_078803.4	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	115							hydrolase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	9						CTCCAGGGCGGCCGGCGGCTC	0.726000													12	47					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118949746	118949746	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:118949746T>C	ENST00000328252.3	+	2	1098	c.729T>C	c.(727-729)agT>agC	p.S243S		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	243					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TAGGGGGCAGTGCCCTGAATC	0.562000													4	149					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37883982	37883982	+	Silent	SNP	G	G	A	rs144501267	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:37883982G>A	ENST00000406381.2	+	29	3873	c.3363G>A	c.(3361-3363)tcG>tcA	p.S1121S	ERBB2_ENST00000540147.1_Silent_p.S1121S|ERBB2_ENST00000541774.1_Silent_p.S1136S|ERBB2_ENST00000445658.2_Silent_p.S875S|ERBB2_ENST00000584601.1_Silent_p.S1121S|ERBB2_ENST00000584450.1_3'UTR|ERBB2_ENST00000269571.5_Silent_p.S1151S	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	1151					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	AGCCCCCTTCGCCCCGAGAGG	0.602000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			21	51					0	0	1	0	0
ELMO2	63916	broad.mit.edu	37	20	45022181	45022181	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:45022181T>C	ENST00000290246.6	-	5	373	c.179A>G	c.(178-180)tAc>tGc	p.Y60C	ELMO2_ENST00000372176.1_5'UTR|ELMO2_ENST00000488853.1_5'UTR|ELMO2_ENST00000352077.2_Missense_Mutation_p.Y60C|ELMO2_ENST00000396391.1_Missense_Mutation_p.Y60C|ELMO2_ENST00000445496.2_5'UTR|ELMO2_ENST00000439931.2_Missense_Mutation_p.Y60C	NM_133171.3	NP_573403.1	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	60					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				TTCGGTGATGTACAGCTGAGG	0.468000													24	371					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6167200	6167200	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6167200A>G	ENST00000261405.5	-	14	1798	c.1544T>C	c.(1543-1545)gTc>gCc	p.V515A		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	515	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CCCGGCATAGACGGGGGACAG	0.577000													17	103					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202722136	202722136	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:202722136A>G	ENST00000367265.3	-	12	2762	c.1598T>C	c.(1597-1599)gTa>gCa	p.V533A	KDM5B_ENST00000367264.2_Missense_Mutation_p.V569A	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	533	JmjC.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TTTCTTCATTACATTTTCTAG	0.448000													29	58					0	0	1	0	0
DSCC1	79075	broad.mit.edu	37	8	120855895	120855895	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:120855895C>T	ENST00000313655.4	-	5	884	c.670G>A	c.(670-672)Gtt>Att	p.V224I		NM_024094.2	NP_076999.2	Q9BVC3	DCC1_HUMAN	DNA replication and sister chromatid cohesion 1	224					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|pancreas(1)	9	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTCAAAGGAACTTTACCAAAA	0.378000													5	278					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2732884	2732884	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2732884G>A	ENST00000269740.4	-	3	1139	c.810C>T	c.(808-810)ggC>ggT	p.G270G	SLC39A3_ENST00000545664.1_Silent_p.G270G|AC006538.4_ENST00000586572.1_Intron	NM_144564.4	NP_653165.2	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	270						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGGTGCCGCCCGCCAGGC	0.672000													22	81					0	0	1	0	0
SLC25A31	83447	broad.mit.edu	37	4	128688369	128688369	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:128688369A>G	ENST00000281154.4	+	4	795	c.627A>G	c.(625-627)acA>acG	p.T209T		NM_031291.2	NP_112581.1	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31	209					transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity			NS(1)|breast(1)|large_intestine(10)|lung(8)|skin(2)	22						CTTATGACACAGTTAAGGTAA	0.338000													12	142					0	0	1	0	0
EIF2A	83939	broad.mit.edu	37	3	150290239	150290239	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:150290239C>T	ENST00000460851.1	+	10	1415	c.1306C>T	c.(1306-1308)Ccc>Tcc	p.P436S	EIF2A_ENST00000273435.5_Missense_Mutation_p.P431S|SERP1_ENST00000490945.1_Intron|EIF2A_ENST00000487799.1_Missense_Mutation_p.P411S|SERP1_ENST00000479209.1_Intron|EIF2A_ENST00000406576.3_Missense_Mutation_p.P375S|EIF2A_ENST00000383043.3_Missense_Mutation_p.P222S			Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A, 65kDa	436					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding			cervix(1)|endometrium(2)|kidney(1)|lung(3)	7		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AAGTGAAGTACCCAATGAGGA	0.373000													9	150					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23900121	23900121	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23900121G>T	ENST00000355349.3	-	10	1046	c.884C>A	c.(883-885)cCt>cAt	p.P295H		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	295	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGCAGCTCAGGCTTTTTGTT	0.498000													18	217					2.35188e-11	2.44398e-11	1	1	0
RD3	343035	broad.mit.edu	37	1	211652549	211652549	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:211652549C>T	ENST00000367002.4	-	3	1580	c.417G>A	c.(415-417)acG>acA	p.T139T	RD3_ENST00000484910.1_5'UTR	NM_001164688.1|NM_183059.2	NP_001158160.1|NP_898882.1	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	139					response to stimulus|visual perception					central_nervous_system(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		TCCACTGGCGCGTCAGCTTGT	0.682000													7	14					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38905911	38905911	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:38905911T>C	ENST00000359357.3	+	76	11328	c.11074T>C	c.(11074-11076)Tac>Cac	p.Y3692H	DNAH8_ENST00000449981.2_Missense_Mutation_p.Y3909H|DNAH8_ENST00000441566.1_Missense_Mutation_p.Y3656H|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAGCATCCTCTACTTCCTCAT	0.517000													21	77					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62148730	62148730	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:62148730C>T	ENST00000416284.3	-	3	1766	c.182G>A	c.(181-183)cGg>cAg	p.R61Q	FAM19A2_ENST00000551619.1_Missense_Mutation_p.R61Q|FAM19A2_ENST00000551449.1_Intron|FAM19A2_ENST00000550003.1_5'UTR	NM_178539.4	NP_848634.1	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	61						cytoplasm				endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		TGTTTGTGACCGTTCTTCTAT	0.483000													28	74					0	0	1	0	0
FAM65B	9750	broad.mit.edu	37	6	24843275	24843275	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:24843275C>T	ENST00000259698.4	-	14	1910	c.1735G>A	c.(1735-1737)Gcc>Acc	p.A579T	FAM65B_ENST00000510784.2_Missense_Mutation_p.A563T|FAM65B_ENST00000473070.1_5'UTR|FAM65B_ENST00000378023.4_Missense_Mutation_p.A529T|FAM65B_ENST00000540914.1_Missense_Mutation_p.A529T|FAM65B_ENST00000538035.1_Missense_Mutation_p.A558T	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	579					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						CTGTCTGTGGCCATTGGCACC	0.512000													10	287					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159713	152159713	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:152159713A>T	ENST00000439251.1	-	2	868	c.430T>A	c.(430-432)Tcc>Acc	p.S144T	PNMA5_ENST00000535214.1_Missense_Mutation_p.S144T|PNMA5_ENST00000452693.1_Missense_Mutation_p.S144T|PNMA5_ENST00000361887.5_Missense_Mutation_p.S144T	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	144					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGGTGGGGATCTAACTTGG	0.537000													25	160					0	0	1	0	0
ZNF432	9668	broad.mit.edu	37	19	52537581	52537581	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:52537581G>A	ENST00000594154.1	-	5	1563	c.1351C>T	c.(1351-1353)Cat>Tat	p.H451Y	ZNF432_ENST00000221315.5_Missense_Mutation_p.H451Y			O94892	ZN432_HUMAN	zinc finger protein 432	451					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCTCCTGTATGAGTTCGCTGA	0.428000													15	66					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56397410	56397410	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56397410G>A	ENST00000394109.3	+	3	961	c.237G>A	c.(235-237)caG>caA	p.Q79Q	SUOX_ENST00000266971.3_Silent_p.Q79Q|SUOX_ENST00000356124.4_Silent_p.Q79Q|SUOX_ENST00000551841.2_Silent_p.Q79Q|SUOX_ENST00000548274.1_Silent_p.Q79Q|SUOX_ENST00000550478.1_3'UTR|SUOX_ENST00000394115.2_Silent_p.Q79Q			P51687	SUOX_HUMAN	sulfite oxidase	79						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			AGGCTGCTCAGGAGTCAACAC	0.498000													4	151					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79426610	79426610	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:79426610A>G	ENST00000307745.7	+	27	5885	c.5885A>G	c.(5884-5886)tAc>tGc	p.Y1962C																								CGATGTCTGTACCCGGGCAAC	0.657000													9	91					0	0	1	0	0
MFSD7	84179	broad.mit.edu	37	4	680338	680338	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:680338C>T	ENST00000322224.4	-	2	590	c.277G>A	c.(277-279)Gtc>Atc	p.V93I	MFSD7_ENST00000404286.2_Missense_Mutation_p.V93I|MFSD7_ENST00000515118.1_Missense_Mutation_p.V93I|MFSD7_ENST00000347950.5_Missense_Mutation_p.V71I|MFSD7_ENST00000513740.1_5'UTR|MFSD7_ENST00000503156.1_Missense_Mutation_p.V29I			Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing 7	93					transmembrane transport	integral to membrane				cervix(1)|kidney(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	11						CGGAGCCCGACGGAGTCCAGG	0.647000													42	112					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981504	70981504	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:70981504T>A	ENST00000276594.2	-	2	793	c.592A>T	c.(592-594)Acg>Tcg	p.T198S		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TCCTCCTCCGTGAACTGGAAC	0.602000													4	118					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123782699	123782699	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123782699C>T	ENST00000420886.2	-	30	3864	c.3865G>A	c.(3865-3867)Gca>Aca	p.A1289T	SBNO1_ENST00000267176.4_Missense_Mutation_p.A1288T|SBNO1_ENST00000602398.1_Missense_Mutation_p.A1289T|SBNO1_ENST00000602750.1_Missense_Mutation_p.A1288T	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1289							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CCCAAGCTTGCTTTTTTGCAA	0.393000													4	129					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56653450	56653450	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:56653450T>A	ENST00000394672.3	+	16	2600	c.2530T>A	c.(2530-2532)Tcc>Acc	p.S844T	CCDC66_ENST00000326595.7_Missense_Mutation_p.S810T|CCDC66_ENST00000436465.2_Missense_Mutation_p.S844T	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	844										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TTCTGAATCATCCCATTTTAT	0.378000													25	69					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89647123	89647123	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:89647123G>A	ENST00000345097.4	-	6	955	c.839C>T	c.(838-840)gCg>gTg	p.A280V	FOXN3_ENST00000261302.5_Missense_Mutation_p.A280V|FOXN3_ENST00000557258.1_Missense_Mutation_p.A258V|FOXN3_ENST00000555353.1_Missense_Mutation_p.A258V	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	280					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CAGGACCCGCGCTCCATTTTG	0.562000													10	20					0	0	1	0	0
BCKDHB	594	broad.mit.edu	37	6	80838882	80838882	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:80838882A>T	ENST00000545529.1	+	3	307	c.279A>T	c.(277-279)atA>atT	p.I93I	BCKDHB_ENST00000369760.4_Silent_p.I93I|BCKDHB_ENST00000356489.5_Silent_p.I93I|BCKDHB_ENST00000320393.6_Silent_p.I93I|BCKDHB_ENST00000486968.1_3'UTR			P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	93					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		TTTCAGTAATATTTGGTGAAG	0.259000													20	71					0	0	1	0	0
FEM1B	10116	broad.mit.edu	37	15	68582120	68582120	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:68582120G>A	ENST00000306917.4	+	2	1039	c.424G>A	c.(424-426)Gaa>Aaa	p.E142K		NM_015322.3	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	142					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						ATACTTGGTTGAAAATAATGC	0.453000													12	55					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101560442	101560442	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:101560442A>G	ENST00000536262.2	-	12	1914	c.1356T>C	c.(1354-1356)atT>atC	p.I452I		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	452					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CCCATAGAGAAATGGCAAATC	0.378000													26	29					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164668	139164668	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:139164668A>G	ENST00000395297.1	-	13	2220	c.2050T>C	c.(2050-2052)Tct>Cct	p.S684P		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	684										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCTGAATCAGATATGATGGAT	0.532000										HNSCC(54;0.14)			49	73					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153677561	153677561	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:153677561A>G	ENST00000297107.6	+	3	460	c.323A>G	c.(322-324)tAc>tGc	p.Y108C	GALNT10_ENST00000425427.2_Missense_Mutation_p.Y108C|GALNT10_ENST00000377661.2_Missense_Mutation_p.Y108C	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	108						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GATCAGGCATACCGAGAAAAT	0.428000													40	123					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16687460	16687460	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16687460T>C	ENST00000263390.3	-	3	1443	c.1181A>G	c.(1180-1182)aAg>aGg	p.K394R	CTD-3222D19.2_ENST00000409035.1_Missense_Mutation_p.K402R	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	394					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						GTACCTCTTCTTCTTTTTACT	0.602000													3	46					0	0	1	0	0
UCKL1	54963	broad.mit.edu	37	20	62577008	62577008	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62577008A>G	ENST00000369908.5	-	5	904	c.605T>C	c.(604-606)tTg>tCg	p.L202S	UCKL1_ENST00000369892.3_Missense_Mutation_p.L217S|UCKL1_ENST00000358711.3_Missense_Mutation_p.L217S|UCKL1_ENST00000354216.6_Missense_Mutation_p.L217S	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	217					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GCTTACCTCCAACAGTGTCTT	0.587000													6	69					0	0	1	0	0
PLEKHF1	79156	broad.mit.edu	37	19	30164827	30164827	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:30164827G>A	ENST00000436066.3	+	2	547	c.81G>A	c.(79-81)caG>caA	p.Q27Q	PLEKHF1_ENST00000592810.1_Silent_p.Q27Q	NM_024310.4	NP_077286.3	Q96S99	PKHF1_HUMAN	pleckstrin homology domain containing, family F (with FYVE domain) member 1	27					apoptosis	lysosome|nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|lung(3)|ovary(1)|prostate(1)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			CCTCGGGGCAGCCGCTGGCGC	0.657000													17	81					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37725149	37725149	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:37725149C>A	ENST00000265107.4	+	16	1867	c.1711C>A	c.(1711-1713)Cca>Aca	p.P571T		NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	571										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGTAGCAGGCCCAGGTGACTG	0.537000													23	83					7.87624e-14	8.22829e-14	1	1	0
ABCC4	10257	broad.mit.edu	37	13	95815404	95815404	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:95815404A>G	ENST00000376887.4	-	18	2394	c.2280T>C	c.(2278-2280)gaT>gaC	p.D760D	ABCC4_ENST00000536256.1_Silent_p.D685D|ABCC4_ENST00000431522.1_Silent_p.D760D|ABCC4_ENST00000412704.1_Silent_p.D713D	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	760	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	ACCAGTTAAGATCTAGCTTCT	0.373000													5	146					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	396838	396838	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:396838C>T	ENST00000262320.3	-	2	559	c.188G>A	c.(187-189)cGc>cAc	p.R63H	AXIN1_ENST00000481769.1_Intron|AXIN1_ENST00000354866.3_Missense_Mutation_p.R63H	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	63					activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CAGATCCGAGCGCCTCGGAGT	0.602000											OREG0003698	type=REGULATORY REGION|Gene=AXIN1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	33					0	0	1	0	0
PLD6	201164	broad.mit.edu	37	17	17106358	17106358	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:17106358A>T	ENST00000321560.3	-	2	510	c.482T>A	c.(481-483)aTc>aAc	p.I161N	RP11-45M22.4_ENST00000427497.3_3'UTR	NM_178836.3	NP_849158.2	Q8N2A8	PLD6_HUMAN	phospholipase D family, member 6	161	PLD phosphodiesterase.				DNA methylation involved in gamete generation|lipid catabolic process|meiosis|mitochondrial fusion|P granule organization|piRNA metabolic process|spermatid development	integral to membrane|mitochondrial outer membrane	cardiolipin hydrolase activity|protein homodimerization activity			endometrium(1)|lung(1)	2						CTTGTCCACGATGGCAAACTT	0.552000													16	71					0	0	1	0	0
ZNF718	255403	broad.mit.edu	37	4	155776	155776	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155776A>G	ENST00000510175.1	+	0	1211							Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		GCCTTTAAACAGTCCTCACAC	0.363000													11	26					0	0	1	0	0
SNX21	90203	broad.mit.edu	37	20	44463689	44463689	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44463689A>G	ENST00000372542.1	+	2	666	c.354A>G	c.(352-354)gcA>gcG	p.A118A	SNX21_ENST00000344780.4_3'UTR|SNX21_ENST00000342644.5_Silent_p.A127A|SNX21_ENST00000462307.1_Silent_p.A127A|SNX21_ENST00000491381.1_Silent_p.A127A|SNX21_ENST00000372541.1_Silent_p.A118A			Q969T3	SNX21_HUMAN	sorting nexin family member 21	127					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|pancreas(1)	7		Myeloproliferative disorder(115;0.0122)				ACACCTTGGCACCCCAGCGGC	0.622000													15	103					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25258486	25258486	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25258486A>G	ENST00000276440.7	+	47	4874	c.4830A>G	c.(4828-4830)aaA>aaG	p.K1610K		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1610	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ATGGGGAGAAACTCACAGAGC	0.488000													27	367					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230337	147230337	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:147230337T>C	ENST00000271348.2	-	2	1171	c.1010A>G	c.(1009-1011)tAt>tGt	p.Y337C	GJA5_ENST00000369237.1_Missense_Mutation_p.Y337C|RP11-433J22.2_ENST00000428911.1_RNA	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	337					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			GTCACTATGATAGCCATGGGG	0.557000													4	109					0	0	1	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240866	26240866	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:26240866A>G	ENST00000377745.2	+	1	306	c.213A>G	c.(211-213)gtA>gtG	p.V71V		NM_003540.3	NP_003531.1	P62805	H4_HUMAN	histone cluster 1, H4f	71				V -> A (in Ref. 14; AAH67496).	CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GGGACGCCGTAACCTACACGG	0.582000													10	63					0	0	1	0	0
DCDC2B	149069	broad.mit.edu	37	1	32674856	32674856	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:32674856T>C	ENST00000409358.1	+	1	162	c.162T>C	c.(160-162)cgT>cgC	p.R54R		NM_001099434.1	NP_001092904.1	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	54	Doublecortin 1.				intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGGCTGTGCGTGCCCTCTACA	0.602000													25	74					0	0	1	0	0
LANCL2	55915	broad.mit.edu	37	7	55467744	55467744	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:55467744T>A	ENST00000254770.2	+	4	1203	c.625T>A	c.(625-627)Tac>Aac	p.Y209N	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	209					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGCCTTACTGTACCTGAACAC	0.483000													36	104					0	0	1	0	0
CTD-3074O7.11	0	broad.mit.edu	37	11	66297301	66297301	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66297301G>A	ENST00000419755.3	+	14	1540	c.1462G>A	c.(1462-1464)Gcc>Acc	p.A488T	ZDHHC24_ENST00000526986.1_Intron|BBS1_ENST00000455748.2_Missense_Mutation_p.A354T|BBS1_ENST00000393994.2_Missense_Mutation_p.A322T|BBS1_ENST00000318312.7_Missense_Mutation_p.A451T																							CATGCACCGGGCCTTCCAGAC	0.677000													37	85					0	0	1	0	0
LIM2	3982	broad.mit.edu	37	19	51883888	51883888	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:51883888A>G	ENST00000221973.3	-	4	499	c.457T>C	c.(457-459)Ttc>Ctc	p.F153L	LIM2_ENST00000596399.1_Missense_Mutation_p.F111L	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	111					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		AACACGACGAAAAGGGCTGgg	0.602000													31	78					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390430	45390430	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:45390430A>G	ENST00000371438.1	+	2	517	c.159A>G	c.(157-159)caA>caG	p.Q53Q	RUNX2_ENST00000541979.1_Silent_p.Q121Q|RUNX2_ENST00000371436.6_Silent_p.Q53Q|RUNX2_ENST00000465038.2_Silent_p.Q53Q|RUNX2_ENST00000359524.5_Silent_p.Q39Q|RUNX2_ENST00000576263.1_Silent_p.Q53Q|RUNX2_ENST00000371432.3_Silent_p.Q39Q|RUNX2_ENST00000352853.5_Silent_p.Q121Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	53	Poly-Gln.		Q -> L (in CLCD).		negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcagcaacagcagcagc	0.726000													25	72					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115422041	115422041	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:115422041G>A	ENST00000337530.6	+	4	2139	c.1843G>A	c.(1843-1845)Ggg>Agg	p.G615R	KIAA1958_ENST00000536272.1_Missense_Mutation_p.G643R	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	615										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						AGTGTGTCACGGGAAGATCTA	0.587000													15	41					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210880	28210880	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:28210880T>C	ENST00000284984.2	-	8	2536	c.2082A>G	c.(2080-2082)ggA>ggG	p.G694G		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	694	Cys-rich.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		TTACACACTGTCCTTGCACAC	0.408000													12	33					0	0	1	0	0
MBD3L1	85509	broad.mit.edu	37	19	8953875	8953875	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:8953875C>T	ENST00000595891.1	+	3	752	c.521C>T	c.(520-522)gCg>gTg	p.A174V	MBD3L1_ENST00000305625.2_Missense_Mutation_p.A174V			Q8WWY6	MB3L1_HUMAN	methyl-CpG binding domain protein 3-like 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	12						GCACTGATTGCGGATGGACTC	0.448000													7	25					0	0	1	0	0
USP43	124739	broad.mit.edu	37	17	9631546	9631546	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:9631546G>A	ENST00000570827.2	+	15	2752	c.1678G>A	c.(1678-1680)Gcc>Acc	p.A560T	USP43_ENST00000285199.6_Missense_Mutation_p.A871T|USP43_ENST00000570475.1_Missense_Mutation_p.A866T			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	871					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						GTCCAACGTCGCCCTTCCTGC	0.627000													14	28					0	0	1	0	0
ASB4	51666	broad.mit.edu	37	7	95115461	95115461	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:95115461T>C	ENST00000325885.5	+	1	249	c.178T>C	c.(178-180)Tat>Cat	p.Y60H	ASB4_ENST00000428113.1_Missense_Mutation_p.Y60H|ASB4_ENST00000257621.4_Intron	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	60					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TTTGGCATCTTATAAACAAGG	0.323000													19	83					0	0	1	0	0
PIGS	94005	broad.mit.edu	37	17	26897899	26897899	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:26897899A>G	ENST00000308360.7	-	3	632	c.257T>C	c.(256-258)gTt>gCt	p.V86A	PIGS_ENST00000543734.1_Missense_Mutation_p.V25A|PIGS_ENST00000395346.2_Missense_Mutation_p.V78A	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	86					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					TTCATGCACAACGGTGAAGGG	0.562000													35	113					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69693187	69693187	+	Missense_Mutation	SNP	G	G	A	rs71615102		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:69693187G>A	ENST00000265403.7	+	5	1255	c.1228G>A	c.(1228-1230)Gca>Aca	p.A410T	UGT2B10_ENST00000458688.2_Missense_Mutation_p.A326T	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	410					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GGCCAAGGGAGCAGCTGTTAG	0.423000													7	191					0	0	1	0	0
C11orf68	83638	broad.mit.edu	37	11	65685199	65685199	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65685199G>A	ENST00000438576.2	-	2	698	c.613C>T	c.(613-615)Cgt>Tgt	p.R205C	C11orf68_ENST00000449692.3_Missense_Mutation_p.R204C|C11orf68_ENST00000530188.1_Missense_Mutation_p.R163C			Q9H3H3	CK068_HUMAN	chromosome 11 open reading frame 68	163										large_intestine(1)|lung(3)	4				READ - Rectum adenocarcinoma(159;0.166)		TCCTTGGCACGTGGGCTCACC	0.642000													19	25					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2816519	2816519	+	Missense_Mutation	SNP	G	G	A	rs138447860	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2816519G>A	ENST00000301740.8	+	11	6539	c.5990G>A	c.(5989-5991)cGc>cAc	p.R1997H		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1997	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						TCTCGATCTCGCACATCTCCA	0.577000													4	103					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7709636	7709636	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7709636A>G	ENST00000441779.2	+	14	1314	c.1277A>G	c.(1276-1278)aAt>aGt	p.N426S	STXBP2_ENST00000414284.2_Missense_Mutation_p.N412S|STXBP2_ENST00000221283.5_Missense_Mutation_p.N415S	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	415					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						CTCCTTCGGAATGGTGGGTGG	0.607000													22	62					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135012647	135012647	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:135012647G>A	ENST00000304613.3	+	14	2656	c.2635G>A	c.(2635-2637)Gtg>Atg	p.V879M	KNDC1_ENST00000368571.2_Missense_Mutation_p.V814M|KNDC1_ENST00000368572.2_Missense_Mutation_p.V879M			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	879	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TCTGCCCTGCGTGGATGCCTC	0.692000													3	10					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68200872	68200872	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:68200872T>C	ENST00000349223.5	+	5	1952	c.1728T>C	c.(1726-1728)agT>agC	p.S576S	NFATC3_ENST00000329524.4_Silent_p.S576S|NFATC3_ENST00000575270.1_Silent_p.S576S|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Silent_p.S576S	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	576	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CACAGCCCAGTGGAAAAGTCC	0.398000													29	110					0	0	1	0	0
RAD18	56852	broad.mit.edu	37	3	8990250	8990250	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:8990250G>A	ENST00000264926.2	-	3	254	c.138C>T	c.(136-138)tgC>tgT	p.C46C	RAD18_ENST00000495087.1_5'UTR	NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	46					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		TACAGAGAGAGCAGTCTGCAA	0.333000								Rad6 pathway					17	138					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94746046	94746046	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:94746046A>G	ENST00000399300.2	-	3	2806	c.2593T>C	c.(2593-2595)Ttt>Ctt	p.F865L	RP11-10N23.4_ENST00000517998.1_RNA|RBM12B_ENST00000517700.1_Missense_Mutation_p.F745L|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	865							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGAGGTCTAAAATTGTCAGGA	0.498000													17	267					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2043156	2043156	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2043156G>A	ENST00000250896.3	-	7	704	c.460C>T	c.(460-462)Cgc>Tgc	p.R154C	MKNK2_ENST00000541165.1_Missense_Mutation_p.R23C|MKNK2_ENST00000309340.7_Missense_Mutation_p.R154C|MKNK2_ENST00000591601.1_Missense_Mutation_p.R154C	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	154	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTAGAAGCGGTCCTCCTCC	0.632000													72	205					0	0	1	0	0
C19orf59	199675	broad.mit.edu	37	19	7743445	7743445	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7743445A>G	ENST00000333598.3	+	5	896	c.442A>G	c.(442-444)Acc>Gcc	p.T148A	CTD-3214H19.16_ENST00000597959.1_Missense_Mutation_p.H20R|C19orf59_ENST00000597445.1_Missense_Mutation_p.T105A	NM_174918.2	NP_777578.2	Q8IX19	MCEM1_HUMAN	chromosome 19 open reading frame 59	148						integral to membrane				endometrium(1)|lung(2)|skin(1)|stomach(1)	5						GCAGAGCATCACCATGGTCAG	0.512000											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	58					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681980	142681980	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:142681980G>A	ENST00000340634.3	-	1	198	c.199C>T	c.(199-201)Ccg>Tcg	p.P67S	RP11-372E1.6_ENST00000594095.1_RNA	NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	67						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						GCCGTGCACGGCAGACGCCGG	0.657000													12	21					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158139231	158139231	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:158139231C>T	ENST00000313708.6	-	14	1762	c.1480G>A	c.(1480-1482)Gcc>Acc	p.A494T	EBF1_ENST00000380654.4_Missense_Mutation_p.A463T|EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Intron	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	494	Pro/Ser/Thr-rich.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GACATTGCGGCAGAGCCGTAT	0.577000			T	HMGA2	lipoma								7	38					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113655205	113655205	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:113655205T>C	ENST00000361127.4	+	14	2101	c.1903T>C	c.(1903-1905)Tgg>Cgg	p.W635R	LRIG2_ENST00000492207.1_3'UTR	NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	635	Ig-like C2-type 2.					cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TCAGATTTCCTGGCAGAAAGA	0.498000													38	125					0	0	1	0	0
TMEM33	55161	broad.mit.edu	37	4	41946932	41946932	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:41946932T>C	ENST00000504986.1	+	5	884	c.519T>C	c.(517-519)ttT>ttC	p.F173F	TMEM33_ENST00000325094.5_Silent_p.F173F|TMEM33_ENST00000513702.1_Silent_p.F173F	NM_018126.2	NP_060596.2	P57088	TMM33_HUMAN	transmembrane protein 33	173						integral to membrane|melanosome	protein binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9						CGACAGTTTTTATGCTTTTTA	0.323000													15	59					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30058575	30058575	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:30058575T>C	ENST00000346128.6	-	5	957	c.483A>G	c.(481-483)gcA>gcG	p.A161A	TJP1_ENST00000545208.2_Silent_p.A161A|TJP1_ENST00000356107.6_Silent_p.A161A|TJP1_ENST00000495972.2_Silent_p.A161A|TJP1_ENST00000400011.2_Silent_p.A165A	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	161					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCTCTCTACTTGCACTTCTAT	0.498000													20	121					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46587855	46587855	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:46587855A>G	ENST00000263734.3	+	5	1043	c.533A>G	c.(532-534)aAc>aGc	p.N178S		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	178					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACGGTCACCAACAGAGGCCGT	0.552000													19	65					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175750	143175750	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:143175750A>G	ENST00000408916.1	+	1	785	c.785A>G	c.(784-786)aAc>aGc	p.N262S	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	262					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TCCATGCAGAACGACTTTTAC	0.473000													29	89					0	0	1	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42271917	42271917	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:42271917G>C	ENST00000389384.4	-	11	1171	c.863C>G	c.(862-864)tCc>tGc	p.S288C	ATXN7L3_ENST00000593073.1_5'UTR|ATXN7L3_ENST00000454077.2_Missense_Mutation_p.S295C	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	288					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		ACTCGTCTTGGAGGAGCCTGA	0.582000													11	34					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31729604	31729604	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31729604A>G	ENST00000493662.2	+	23	2298	c.2242A>G	c.(2242-2244)Acc>Gcc	p.T748A	MSH5_ENST00000375755.3_Missense_Mutation_p.T731A|MSH5-SAPCD1_ENST00000491552.1_3'UTR|MSH5_ENST00000431848.2_Missense_Mutation_p.T430A|MSH5_ENST00000375703.3_Missense_Mutation_p.T732A|MSH5_ENST00000534153.4_Missense_Mutation_p.T748A|MSH5_ENST00000375740.3_Missense_Mutation_p.T749A|MSH5_ENST00000375742.3_Missense_Mutation_p.T748A|MSH5_ENST00000375750.3_Missense_Mutation_p.T731A|MSH5_ENST00000395853.1_Missense_Mutation_p.T405A																							GACCATGGAGACCTGTGAGGA	0.517000													78	213					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	113980283	113980283	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:113980283A>G	ENST00000375430.4	-	6	732	c.686T>C	c.(685-687)cTg>cCg	p.L229P	GRTP1_ENST00000326039.3_Missense_Mutation_p.L151P|GRTP1_ENST00000375431.4_Missense_Mutation_p.L229P			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	229	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GCGGGACACCAGCAGCGTCCA	0.697000													27	88					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242757535	242757535	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:242757535G>A	ENST00000391969.2	+	5	1327	c.616G>A	c.(616-618)Ggc>Agc	p.G206S	NEU4_ENST00000405370.1_Missense_Mutation_p.G206S|NEU4_ENST00000325935.6_Missense_Mutation_p.G219S|NEU4_ENST00000404257.1_Missense_Mutation_p.G218S|NEU4_ENST00000407683.1_Missense_Mutation_p.G206S	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	206						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CGATGACCACGGCCGCACCTG	0.677000													18	21					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18332378	18332378	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18332378G>A	ENST00000396253.3	-	4	507	c.45C>T	c.(43-45)ctC>ctT	p.L15L	HPS5_ENST00000438420.2_Silent_p.L15L|HPS5_ENST00000531848.1_Silent_p.L15L|HPS5_ENST00000349215.3_Silent_p.L129L	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	129						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TATCCCAGCAGAGAGCTGTGA	0.428000									Hermansky-Pudlak syndrome				21	61					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96752283	96752283	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:96752283C>T	ENST00000359933.4	-	42	6939	c.6046G>A	c.(6046-6048)Gct>Act	p.A2016T		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	2016										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGTTCTCGAGCCGCAGTTTCA	0.567000													8	21					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171753286	171753286	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:171753286C>T	ENST00000361735.3	+	2	826	c.560C>T	c.(559-561)gCc>gTc	p.A187V	METTL13_ENST00000458517.1_Missense_Mutation_p.A186V|METTL13_ENST00000367737.5_Intron|METTL13_ENST00000362019.3_Missense_Mutation_p.A101V	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	187							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						CACCAAGTGGCCAACAGCCAG	0.587000													31	84					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814022	123814022	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:123814022T>C	ENST00000321252.2	-	1	558	c.524A>G	c.(523-525)gAc>gGc	p.D175G		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AAAGAAGTGGTCAATACCATT	0.557000													25	71					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18833006	18833006	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:18833006C>A	ENST00000406451.3	+	17	2394	c.2244C>A	c.(2242-2244)tcC>tcA	p.S748S	HDAC9_ENST00000441542.2_Silent_p.S751S|HDAC9_ENST00000432645.2_Silent_p.S748S|HDAC9_ENST00000401921.1_Silent_p.S707S	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	748	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TACACTCGTCCGGTGCTGCAC	0.527000													4	6					3.59834e-05	3.66827e-05	1	1	0
TRIM16	10626	broad.mit.edu	37	17	15554474	15554474	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:15554474G>A	ENST00000455584.2	-	1	493	c.450C>T	c.(448-450)tgC>tgT	p.C150C	TRIM16_ENST00000336708.7_Silent_p.C150C|TRIM16_ENST00000416464.2_Intron|TRIM16_ENST00000578237.1_Silent_p.C150C|TRIM16_ENST00000581224.1_Intron																							AACAGTCCTGGCAGATGCACT	0.602000													16	89					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	6030501	6030501	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6030501G>T	ENST00000546188.1	-	3	298	c.227C>A	c.(226-228)cCt>cAt	p.P76H	ANO2_ENST00000356134.5_Missense_Mutation_p.P76H|ANO2_ENST00000327087.8_Missense_Mutation_p.P76H			Q9NQ90	ANO2_HUMAN	anoctamin 2	80						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CAAGGACACAGGCTCATTGGC	0.557000													19	81					1.00905e-13	1.05366e-13	1	1	0
RNF111	54778	broad.mit.edu	37	15	59323315	59323315	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:59323315G>A	ENST00000348370.4	+	2	727	c.294G>A	c.(292-294)caG>caA	p.Q98Q	RNF111_ENST00000434298.1_Silent_p.Q98Q|RNF111_ENST00000559209.1_Silent_p.Q98Q|RNF111_ENST00000561186.1_Silent_p.Q98Q|RNF111_ENST00000557998.1_Silent_p.Q98Q	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	98					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		GCAAAAGCCAGCAGGCTGGCC	0.423000													22	85					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140407245	140407245	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:140407245A>G	ENST00000286349.3	+	3	1912	c.1721A>G	c.(1720-1722)tAc>tGc	p.Y574C		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	574						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CTCTACACCTACTGGAGTGCT	0.577000													8	167					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91603150	91603150	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:91603150T>A	ENST00000359028.2	+	3	435	c.210T>A	c.(208-210)gaT>gaA	p.D70E	AKAP9_ENST00000394564.1_Missense_Mutation_p.D58E|AKAP9_ENST00000358100.2_Missense_Mutation_p.D70E|AKAP9_ENST00000356239.3_Missense_Mutation_p.D58E			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	70					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGAATATTGATCAATCACAGT	0.368000			T	BRAF	papillary thyroid								16	51					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2749646	2749646	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:2749646G>A	ENST00000382611.6	-	2	753	c.505C>T	c.(505-507)Cgc>Tgc	p.R169C	IRX2_ENST00000302057.5_Missense_Mutation_p.R169C|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	169						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R169C(1)		breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		AGGCGCCGGCGCGCGTTGGCG	0.597000													34	127					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192078265	192078265	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:192078265G>A	ENST00000454309.2	-	2	1087	c.262C>T	c.(262-264)Cac>Tac	p.H88Y	FGF12_ENST00000430714.1_Intron|FGF12_ENST00000264730.3_Missense_Mutation_p.H26Y|FGF12_ENST00000450716.1_Missense_Mutation_p.H26Y|FGF12_ENST00000445105.1_Missense_Mutation_p.H26Y	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	88					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		CCATCTGGGTGCATCTGCAGG	0.408000													6	91					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35035325	35035325	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:35035325A>G	ENST00000231420.6	-	5	782		c.e5+1			NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2						glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	AGTTGTGATTACCTGAAAGAA	0.443000													26	116					0	0	1	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110023726	110023726	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:110023726A>G	ENST00000453089.2	+	2	1644	c.763A>G	c.(763-765)Aca>Gca	p.T255A	ZC3H12C_ENST00000528673.1_Missense_Mutation_p.T287A|ZC3H12C_ENST00000278590.3_Missense_Mutation_p.T286A			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	286							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		CAAAGACATTACAGTTTTTGT	0.428000													9	27					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	983037	983037	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:983037C>T	ENST00000379370.2	+	21	3651	c.3601C>T	c.(3601-3603)Cgc>Tgc	p.R1201C		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1201	SEA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CAAATCCGTCCGCGCCATTGT	0.617000													22	82					0	0	1	0	0
MBD6	114785	broad.mit.edu	37	12	57920551	57920551	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:57920551G>A	ENST00000355673.3	+	7	1979	c.1623G>A	c.(1621-1623)ttG>ttA	p.L541L	MBD6_ENST00000431731.2_Silent_p.L541L	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	541	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						TTGGGGCCTTGCCTCTCCCTC	0.627000													27	86					0	0	1	0	0
G3BP1	10146	broad.mit.edu	37	5	151179896	151179896	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:151179896A>T	ENST00000394123.3	+	10	1218	c.1073A>T	c.(1072-1074)gAt>gTt	p.D358V	G3BP1_ENST00000356245.3_Missense_Mutation_p.D358V|G3BP1_ENST00000543466.1_Missense_Mutation_p.D176V			Q13283	G3BP1_HUMAN	GTPase activating protein (SH3 domain) binding protein 1	358	RRM.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|skin(3)|urinary_tract(2)	29		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GAGCTTAAAGATTTCTTTCAA	0.403000													19	52					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102270375	102270375	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:102270375G>T	ENST00000370103.4	-	6	1009	c.796C>A	c.(796-798)Ctt>Att	p.L266I	OLFM3_ENST00000338858.5_Missense_Mutation_p.L286I|OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000536598.1_3'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	286	Olfactomedin-like.					extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTGAAAGGAAGGTTGTATGTC	0.368000													31	76					3.69857e-22	3.90823e-22	1	1	0
ZNF396	252884	broad.mit.edu	37	18	32949530	32949530	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:32949530A>G	ENST00000306346.1	-	4	788	c.657T>C	c.(655-657)caT>caC	p.H219H	ZNF396_ENST00000589332.1_Silent_p.H219H	NM_145756.2	NP_665699.1	Q96N95	ZN396_HUMAN	zinc finger protein 396	219					viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	7						AGCCATTCATATGAAGGATAT	0.368000													37	101					0	0	1	0	0
CCDC97	90324	broad.mit.edu	37	19	41828524	41828524	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41828524C>T	ENST00000269967.3	+	5	1058	c.936C>T	c.(934-936)ttC>ttT	p.F312F		NM_052848.1	NP_443080.1	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	312										biliary_tract(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	17						ACCCCGACTTCGACAACCTCG	0.617000													55	122					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56711540	56711540	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:56711540A>G	ENST00000260129.5	+	8	2087	c.1610A>G	c.(1609-1611)cAt>cGt	p.H537R		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	537					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TCATCTTCTCATGACAATGTG	0.383000													25	72					0	0	1	0	0
CEPT1	10390	broad.mit.edu	37	1	111702064	111702064	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:111702064T>C	ENST00000545121.1	+	3	610	c.402T>C	c.(400-402)gcT>gcC	p.A134A	CEPT1_ENST00000357172.4_Silent_p.A134A	NM_001007794.1	NP_001007795.1	Q9Y6K0	CEPT1_HUMAN	choline/ethanolamine phosphotransferase 1	134						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	8		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	CTTTGGATGCTATTGATGGGA	0.398000													23	112					0	0	1	0	0
DCAF4	26094	broad.mit.edu	37	14	73412598	73412598	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:73412598A>G	ENST00000553457.1	+	6	531	c.241A>G	c.(241-243)Acc>Gcc	p.T81A	DCAF4_ENST00000394234.2_Missense_Mutation_p.T81A|DCAF4_ENST00000509153.1_Missense_Mutation_p.T120A|DCAF4_ENST00000358377.2_Missense_Mutation_p.T181A|DCAF4_ENST00000353777.3_Missense_Mutation_p.T120A|DCAF4_ENST00000555042.1_Missense_Mutation_p.T181A			Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	181						CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						CCAGGCAGATACCAACAGTGA	0.577000													109	413					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48692731	48692731	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:48692731G>A	ENST00000352832.5	+	25	5039	c.4667G>A	c.(4666-4668)tGc>tAc	p.C1556Y	CACNA1G_ENST00000503485.1_Missense_Mutation_p.C1556Y|CACNA1G_ENST00000354983.4_Missense_Mutation_p.C1556Y|CACNA1G_ENST00000359106.5_Missense_Mutation_p.C1590Y|CACNA1G_ENST00000515411.1_Missense_Mutation_p.C1572Y|CACNA1G_ENST00000514181.1_Missense_Mutation_p.C1572Y|CACNA1G_ENST00000505165.1_Missense_Mutation_p.C1590Y|CACNA1G_ENST00000514079.1_Missense_Mutation_p.C1597Y|CACNA1G_ENST00000510366.1_Missense_Mutation_p.C1538Y|CACNA1G_ENST00000513964.1_Missense_Mutation_p.C1545Y|CACNA1G_ENST00000515165.1_Missense_Mutation_p.C1590Y|CACNA1G_ENST00000515765.1_Missense_Mutation_p.C1579Y|CACNA1G_ENST00000514717.1_Missense_Mutation_p.C1533Y|CACNA1G_ENST00000442258.2_Missense_Mutation_p.C1549Y|CACNA1G_ENST00000507510.2_Missense_Mutation_p.C1590Y|CACNA1G_ENST00000502264.1_Missense_Mutation_p.C1567Y|CACNA1G_ENST00000507609.1_Missense_Mutation_p.C1590Y|CACNA1G_ENST00000507336.1_Missense_Mutation_p.C1579Y|CACNA1G_ENST00000510115.1_Missense_Mutation_p.C1556Y|CACNA1G_ENST00000507896.1_Missense_Mutation_p.C1579Y|CACNA1G_ENST00000358244.5_Missense_Mutation_p.C1556Y|CACNA1G_ENST00000513689.2_Missense_Mutation_p.C1545Y|CACNA1G_ENST00000429973.2_Missense_Mutation_p.C1572Y|CACNA1G_ENST00000512389.1_Missense_Mutation_p.C1579Y|CACNA1G_ENST00000360761.4_Missense_Mutation_p.C1567Y	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1590					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GAAGCCCAGTGCAAACCTTAC	0.632000													18	53					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235866193	235866193	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:235866193T>C	ENST00000389794.3	-	45	10402	c.10228A>G	c.(10228-10230)Act>Gct	p.T3410A	LYST_ENST00000389793.2_Missense_Mutation_p.T3410A|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3410	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGACGGGGAGTCTGCCCGTAG	0.502000													60	220					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71125077	71125077	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:71125077C>T	ENST00000299213.8	-	3	860	c.790G>A	c.(790-792)Gag>Aag	p.E264K		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	264					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						TCCACCTCCTCGAACTCCACG	0.562000													17	56					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11872631	11872631	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:11872631A>G	ENST00000262442.3	+	69	13316	c.13248A>G	c.(13246-13248)acA>acG	p.T4416T	DNAH9_ENST00000454412.2_Silent_p.T4340T|RP11-1096G20.5_ENST00000580270.1_RNA|DNAH9_ENST00000396001.2_Silent_p.T728T	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4416					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGATCATTACAGAGGCAAAGC	0.522000													29	96					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46837797	46837797	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:46837797T>C	ENST00000529230.1	-	4	456	c.410A>G	c.(409-411)aAt>aGt	p.N137S	CKAP5_ENST00000312055.5_Missense_Mutation_p.N137S|CKAP5_ENST00000415402.1_Missense_Mutation_p.N137S|CKAP5_ENST00000354558.3_Missense_Mutation_p.N137S			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	137					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						GATCTTGGGATTCTTATTGTC	0.428000													9	157					0	0	1	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964151	7964151	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7964151C>T	ENST00000306708.6	+	3	845	c.744C>T	c.(742-744)ggC>ggT	p.G248G	AC010336.1_ENST00000539278.1_3'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	248						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						TGGAAGAGGGCGACATCCTGT	0.527000													19	47					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95595892	95595892	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:95595892C>A	ENST00000526495.1	-	8	942	c.651G>T	c.(649-651)gaG>gaT	p.E217D	DICER1_ENST00000343455.3_Missense_Mutation_p.E217D|DICER1_ENST00000541352.1_Missense_Mutation_p.E217D|DICER1_ENST00000393063.1_Missense_Mutation_p.E217D|DICER1_ENST00000527414.1_Missense_Mutation_p.E217D			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	217	Helicase ATP-binding.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CTTCCAATTCCTCTGGATCAC	0.378000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				18	38					4.75885e-15	4.98425e-15	1	1	0
MSANTD2	79684	broad.mit.edu	37	11	124637135	124637135	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:124637135G>A	ENST00000526629.1	-	3	2374	c.927C>T	c.(925-927)tcC>tcT	p.S309S	MSANTD2_ENST00000374979.3_Silent_p.S539S|MSANTD2_ENST00000239614.4_Silent_p.S487S			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	539																	AAGAGCCTGCGGAAAGAAAAT	0.413000													41	105					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173817	126173817	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:126173817C>T	ENST00000339582.2	-	9	2427	c.1619G>A	c.(1618-1620)cGc>cAc	p.R540H	GRM8_ENST00000358373.3_Missense_Mutation_p.R540H|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Missense_Mutation_p.R540H			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	540					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ACCTTCACAGCGTTCACAGTG	0.562000										HNSCC(24;0.065)			23	103					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123658396	123658396	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:123658396G>A	ENST00000369043.3	-	7	988	c.902C>T	c.(901-903)gCc>gTc	p.A301V	ATE1_ENST00000543447.1_Intron|ATE1_ENST00000369040.3_Missense_Mutation_p.A205V|ATE1_ENST00000481784.1_Intron|ATE1_ENST00000224652.6_Intron|ATE1_ENST00000540606.1_Missense_Mutation_p.A294V|ATE1_ENST00000535655.1_Intron	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	301					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				CTGGTGTATGGCCACTTGATA	0.428000													25	81					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95590933	95590933	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:95590933C>A	ENST00000526495.1	-	10	1267	c.976G>T	c.(976-978)Gta>Tta	p.V326L	DICER1_ENST00000343455.3_Missense_Mutation_p.V326L|DICER1_ENST00000541352.1_Missense_Mutation_p.V326L|DICER1_ENST00000393063.1_Missense_Mutation_p.V326L|DICER1_ENST00000527414.1_Missense_Mutation_p.V326L			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	326	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AGTTCTCTTACCATCATTCCA	0.378000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				9	101					4.68919e-08	4.83164e-08	1	1	0
TLN2	83660	broad.mit.edu	37	15	63125774	63125774	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:63125774C>T	ENST00000561311.1	+	54	7304	c.7074C>T	c.(7072-7074)agC>agT	p.S2358S	RP11-1069G10.1_ENST00000558888.1_RNA|TLN2_ENST00000306829.6_Silent_p.S2358S			Q9Y4G6	TLN2_HUMAN	talin 2	2358	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CTGCCACAAGCGCCCTGGTCA	0.537000													31	125					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27367196	27367196	+	Silent	SNP	C	C	T	rs140725309	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27367196C>T	ENST00000395762.2	+	8	997	c.738C>T	c.(736-738)gcC>gcT	p.A246A	IL4R_ENST00000380922.3_Silent_p.A231A|IL4R_ENST00000543915.2_Silent_p.A246A|IL4R_ENST00000565915.1_3'UTR|IL4R_ENST00000170630.2_Silent_p.A246A	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	246					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity	p.A246A(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						TCATCCTGGCCGTCTGCCTGT	0.622000													27	109					0	0	1	0	0
ISL2	64843	broad.mit.edu	37	15	76632620	76632620	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:76632620C>T	ENST00000290759.4	+	4	675	c.515C>T	c.(514-516)gCt>gTt	p.A172V	RP11-685G9.2_ENST00000559539.1_RNA	NM_145805.1	NP_665804.1	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	172						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6						CTGGCAGACGCTGGGTCGGGC	0.716000													5	17					0	0	1	0	0
TMPO	7112	broad.mit.edu	37	12	98941405	98941405	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:98941405T>C	ENST00000556029.1	+	9	1490	c.1134T>C	c.(1132-1134)agT>agC	p.S378S	TMPO_ENST00000343315.5_Silent_p.S338S|TMPO_ENST00000393053.2_Silent_p.S269S|TMPO_ENST00000548223.1_3'UTR	NM_001032283.2	NP_001027454.1	P42167	LAP2B_HUMAN	thymopoietin	378	Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TAGAACTCAGTGATTTCAGGA	0.428000													9	93					0	0	1	0	0
FBXO11	80204	broad.mit.edu	37	2	48040949	48040949	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:48040949T>C	ENST00000403359.3	-	17	2136	c.2064A>G	c.(2062-2064)ggA>ggG	p.G688G	FBXO11_ENST00000434523.2_Silent_p.G112G|FBXO11_ENST00000402508.1_Silent_p.G604G|FBXO11_ENST00000316377.4_Silent_p.G604G	NM_001190274.1	NP_001177203.1	Q86XK2	FBX11_HUMAN	F-box protein 11	688					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding	p.0?(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAACTAGAATTCCACCATTCT	0.393000			"""Mis, F, D"""		DLBCL								4	56					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308700	248308700	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248308700A>G	ENST00000366476.1	+	1	251	c.251A>G	c.(250-252)aAc>aGc	p.N84S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATGGCCTTCAACTACTTGTCT	0.498000													10	413					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457746	110457746	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:110457746G>A	ENST00000378402.5	+	38	5752	c.5648G>A	c.(5647-5649)cGc>cAc	p.R1883H		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1883	IPT/TIG 11.				immune response	cytosol|extracellular space|integral to membrane	receptor activity	p.R1883H(1)|p.R1885H(1)		NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTCTACTGCCGCACTCCCGCT	0.438000										HNSCC(38;0.096)			5	26					0	0	1	0	0
EIF1AD	84285	broad.mit.edu	37	11	65766125	65766125	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65766125T>C	ENST00000312234.2	-	6	777	c.443A>G	c.(442-444)aAc>aGc	p.N148S	EIF1AD_ENST00000525767.1_Missense_Mutation_p.N96S|EIF1AD_ENST00000527249.1_Missense_Mutation_p.N148S|EIF1AD_ENST00000533544.1_Missense_Mutation_p.N148S|EIF1AD_ENST00000526451.1_Missense_Mutation_p.N148S	NM_001242481.1|NM_001242482.1|NM_001242483.1|NM_032325.3	NP_001229410.1|NP_001229411.1|NP_001229412.1|NP_115701.2	Q8N9N8	EIF1A_HUMAN	eukaryotic translation initiation factor 1A domain containing	148						nucleus	translation initiation factor activity			lung(5)	5						CTGTCTGCGGTTTGTGTTAAC	0.532000													5	281					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30921832	30921832	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:30921832T>C	ENST00000543491.1	+	2	3232	c.3232T>C	c.(3232-3234)Tca>Cca	p.S1078P	PCDH7_ENST00000509925.1_3'UTR			O60245	PCDH7_HUMAN	protocadherin 7	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						ACATCAGGGGTCACTGCAGAG	0.502000													8	86					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58752199	58752199	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:58752199T>C	ENST00000245206.5	-	6	731	c.603A>G	c.(601-603)atA>atG	p.I201M	GOT2_ENST00000564400.1_5'UTR|GOT2_ENST00000434819.2_Missense_Mutation_p.I158M	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	201					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TCTGCTCTGGTATTTTCTAAA	0.463000													11	80					0	0	1	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044343	90044343	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:90044343T>C	ENST00000462693.1	+	0	294																											ACAGATTCAGTGGCAGTGGGG	0.507000													7	302					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224462507	224462507	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:224462507G>A	ENST00000305409.2	-	2	1726	c.1494C>T	c.(1492-1494)aaC>aaT	p.N498N		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	498					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GATCCTTGTCGTTCAGGTTTT	0.453000													31	121					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35706785	35706785	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35706785G>A	ENST00000314888.9	-	38	5421	c.5068C>T	c.(5068-5070)Cgt>Tgt	p.R1690C	TLN1_ENST00000464379.1_Intron|TLN1_ENST00000540444.1_Splice_Site_p.L1690_splice	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1690	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding	p.R1690S(1)		NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ATTCCCTCACGGGGAGCAAGC	0.532000													44	123					0	0	1	0	0
ZNF764	92595	broad.mit.edu	37	16	30566842	30566842	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30566842C>T	ENST00000395091.2	-	3	1212	c.897G>A	c.(895-897)tcG>tcA	p.S299S	ZNF764_ENST00000252797.2_Silent_p.S300S|AC002310.13_ENST00000568114.1_Intron			Q96H86	ZN764_HUMAN	zinc finger protein 764	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7						GCCGCAGGTCCGAGGGGTAGG	0.726000													9	21					0	0	1	0	0
TAS2R50	259296	broad.mit.edu	37	12	11138911	11138911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:11138911C>T	ENST00000506868.1	-	1	600	c.549G>A	c.(547-549)tgG>tgA	p.W183*	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176890.2	NP_795371.2	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	183					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						GTATGAAGCTCCATAGGGTAG	0.403000													42	152					0	0	1	0	0
NLE1	54475	broad.mit.edu	37	17	33460199	33460199	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:33460199C>A	ENST00000586869.1	-	11	1579	c.560G>T	c.(559-561)tGc>tTc	p.C187F	NLE1_ENST00000442241.4_Missense_Mutation_p.C479F|NLE1_ENST00000360831.5_Missense_Mutation_p.C437F			Q9NVX2	NLE1_HUMAN	notchless homolog 1 (Drosophila)	479						nucleolus				NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	22		Ovarian(249;0.17)				CATCCGGAGGCATTTGTCCTT	0.552000													4	124					0.00116845	0.00118101	1	1	0
MAPKAPK3	7867	broad.mit.edu	37	3	50677902	50677902	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:50677902C>T	ENST00000446044.1	+	5	921	c.325C>T	c.(325-327)Cat>Tat	p.H109Y	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.H109Y	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	109	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		GAACATGCACCATGGCAAGCG	0.607000													5	295					0	0	1	0	0
AIF1	199	broad.mit.edu	37	6	31584617	31584617	+	Silent	SNP	G	G	A	rs148972430		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31584617G>A	ENST00000376059.3	+	6	530	c.384G>A	c.(382-384)gcG>gcA	p.A128A	AIF1_ENST00000376049.4_Silent_p.A74A	NM_001623.3	NP_001614.3	P55008	AIF1_HUMAN	allograft inflammatory factor 1	128					actin filament bundle assembly|cell cycle arrest|inflammatory response|negative regulation of cell proliferation	nucleus|ruffle membrane	actin filament binding|calcium ion binding			lung(2)|ovary(1)	3						AGGAAAAAGCGAGAGAAAAGG	0.488000													15	69					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563545	140563545	+	Missense_Mutation	SNP	G	G	A	rs143024827		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140563545G>A	ENST00000361016.2	+	1	2566	c.1411G>A	c.(1411-1413)Ggc>Agc	p.G471S		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		471	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCACATCGGCAGCGTCAG	0.622000													4	144					0	0	1	0	0
C20orf141	128653	broad.mit.edu	37	20	2796271	2796271	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:2796271T>C	ENST00000380589.4	+	2	522	c.348T>C	c.(346-348)gcT>gcC	p.A116A	C20orf141_ENST00000603872.1_Silent_p.A116A|TMEM239_ENST00000554164.1_Intron|TMEM239_ENST00000380593.4_Intron	NM_080739.2	NP_542777.1	Q9NUB4	CT141_HUMAN	chromosome 20 open reading frame 141	116	Leu-rich.					integral to membrane				endometrium(4)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	10						AGCAGGAGGCTCTACTCCTGC	0.627000													12	43					0	0	1	0	0
RARA	5914	broad.mit.edu	37	17	38511548	38511548	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:38511548A>G	ENST00000254066.5	+	8	1501	c.1046A>G	c.(1045-1047)gAc>gGc	p.D349G	RARA_ENST00000394089.2_Missense_Mutation_p.D349G|RARA_ENST00000394081.3_Missense_Mutation_p.D344G|RARA_ENST00000394086.3_Missense_Mutation_p.D365G|RARA_ENST00000425707.3_Missense_Mutation_p.D252G|RARA_ENST00000420042.1_3'UTR	NM_000964.3	NP_000955.1	P10276	RARA_HUMAN	retinoic acid receptor, alpha	349	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(1)|kidney(4)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|urinary_tract(2)	16		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	GACCGGGTGGACATGCTGCAG	0.652000			T	"""PML, ZNF145, TIF1, NUMA1, NPM1"""	APL						OREG0024394	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	10					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66255090	66255090	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:66255090G>T	ENST00000405643.1	+	1	393	c.15G>T	c.(13-15)cgG>cgT	p.R5R	MAST4_ENST00000403625.2_Intron|MAST4_ENST00000406039.1_Intron|MAST4_ENST00000407621.1_Silent_p.R5R|MAST4_ENST00000490016.2_Intron|MAST4_ENST00000404260.3_Intron|MAST4_ENST00000406374.1_Intron|MAST4_ENST00000403666.1_Intron			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1094						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AAGCCCAGCGGGAAAGGCTAC	0.483000													15	56					6.31663e-08	6.50258e-08	1	1	0
OSBPL11	114885	broad.mit.edu	37	3	125249420	125249420	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:125249420T>C	ENST00000296220.5	-	13	2472	c.2183A>G	c.(2182-2184)gAt>gGt	p.D728G		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	728					lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						AACCCAGCCATCTCCCTGAAA	0.348000													9	19					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24254870	24254870	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:24254870C>A	ENST00000538205.1	+	7	838	c.291C>A	c.(289-291)aaC>aaA	p.N97K	RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000522298.1_Missense_Mutation_p.N97K|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Missense_Mutation_p.N176K	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	176					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTACATCTAACCAGGAGGAAC	0.458000													8	348					0.000157383	0.00015972	1	1	0
C1QTNF4	114900	broad.mit.edu	37	11	47612220	47612220	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47612220A>G	ENST00000302514.3	-	2	659	c.143T>C	c.(142-144)gTg>gCg	p.V48A		NM_031909.2	NP_114115.2	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	48	C1q 1.					extracellular region				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						GTCGAAGGTCACCGCCATCTC	0.697000													8	24					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14369559	14369559	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:14369559G>A	ENST00000344204.4	+	18	3167	c.3143G>A	c.(3142-3144)gGc>gAc	p.G1048D	TRIO_ENST00000509967.2_Missense_Mutation_p.G999D|TRIO_ENST00000537187.1_Missense_Mutation_p.G1048D	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1048					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GATAAGCTGGGCCCAAACTCT	0.592000													22	73					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70120498	70120498	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:70120498A>G	ENST00000245479.2	+	3	1872	c.1500A>G	c.(1498-1500)caA>caG	p.Q500Q		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	500					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			ACTGGGAACAACCCGTCTACA	0.597000													28	86					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958820	53958820	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53958820T>C	ENST00000454407.1	+	0	1512							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GAGAGAAACCTTACAAGTGTA	0.408000													7	271					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140901252	140901252	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140901252T>C	ENST00000371372.1	+	16	2153	c.2008T>C	c.(2008-2010)Tat>Cat	p.Y670H	CACNA1B_ENST00000371357.1_Missense_Mutation_p.Y671H|CACNA1B_ENST00000277551.2_Missense_Mutation_p.Y670H|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371363.1_Missense_Mutation_p.Y670H|CACNA1B_ENST00000371355.4_Missense_Mutation_p.Y671H	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	670					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGCAGTGATGTATCACGGGAT	0.567000													4	24					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108523240	108523240	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:108523240G>C	ENST00000281092.4	+	20	2817	c.2433G>C	c.(2431-2433)caG>caC	p.Q811H	FER_ENST00000438717.2_Missense_Mutation_p.Q636H	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	811	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GTGAACTTCAGAAAGAGCTCA	0.443000													21	67					0	0	1	0	0
ASNSD1	54529	broad.mit.edu	37	2	190531561	190531561	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:190531561C>T	ENST00000260952.4	+	4	1116	c.703C>T	c.(703-705)Ctg>Ttg	p.L235L	ASNSD1_ENST00000607062.1_Intron	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	235					asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			TGAAGCCAAACTGTATCTTGA	0.363000													25	104					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145007143	145007143	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145007143C>T	ENST00000322810.4	-	14	2135	c.1966G>A	c.(1966-1968)Gac>Aac	p.D656N	PLEC_ENST00000527096.1_Missense_Mutation_p.D542N|PLEC_ENST00000356346.3_Missense_Mutation_p.D505N|PLEC_ENST00000436759.2_Missense_Mutation_p.D546N|PLEC_ENST00000357649.2_Missense_Mutation_p.D523N|PLEC_ENST00000354589.3_Missense_Mutation_p.D519N|PLEC_ENST00000398774.2_Missense_Mutation_p.D487N|PLEC_ENST00000345136.3_Missense_Mutation_p.D519N|PLEC_ENST00000354958.2_Missense_Mutation_p.D497N	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	656	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AGAGTGGAGTCCTCCAGCTCG	0.672000													12	33					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32041536	32041536	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32041536G>A	ENST00000375244.3	-	12	4770	c.4569C>T	c.(4567-4569)gaC>gaT	p.D1523D	TNXB_ENST00000375247.2_Silent_p.D1523D			P22105	TENX_HUMAN	tenascin XB	1610	Fibronectin type-III 7.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCTCTCGCTGGTCTGCCGCCA	0.577000													13	24					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150063646	150063646	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:150063646A>G	ENST00000340413.2	-	4	458	c.382T>C	c.(382-384)Tcc>Ccc	p.S128P	NUP43_ENST00000460354.2_Missense_Mutation_p.S128P|NUP43_ENST00000367404.4_Missense_Mutation_p.S128P|NUP43_ENST00000367403.3_Missense_Mutation_p.S189P	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	128					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CTGCTATAGGAAGGACTGCCA	0.463000													26	122					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28935124	28935124	+	Missense_Mutation	SNP	G	G	A	rs145472309		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:28935124G>A	ENST00000257192.4	+	15	3177	c.2965G>A	c.(2965-2967)Ggt>Agt	p.G989S	DSG1_ENST00000462981.2_Missense_Mutation_p.G348S|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	989	Gly/Ser-rich.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TGCTGGGAGCGGTGCCCTGAG	0.597000													9	118					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688852	26688852	+	Missense_Mutation	SNP	C	C	T	rs138721720	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:26688852C>T	ENST00000529632.2	+	2	771	c.575C>T	c.(574-576)gCg>gTg	p.A192V	SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000360929.3_Missense_Mutation_p.A192V|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000404234.3_Missense_Mutation_p.A192V|SEZ6L_ENST00000248933.6_Missense_Mutation_p.A192V|SEZ6L_ENST00000343706.4_Missense_Mutation_p.A192V	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	192						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						AAGGAGAGTGCGGTCCCTACA	0.667000													30	138					0	0	1	0	0
MORF4L1	10933	broad.mit.edu	37	15	79186493	79186493	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:79186493G>A	ENST00000331268.5	+	11	1044	c.840G>A	c.(838-840)caG>caA	p.Q280Q	MORF4L1_ENST00000558746.1_Silent_p.Q214Q|MORF4L1_ENST00000561171.1_Intron|MORF4L1_ENST00000559345.1_Silent_p.Q153Q|MORF4L1_ENST00000558502.1_Silent_p.Q153Q|MORF4L1_ENST00000426013.2_Silent_p.Q241Q|MORF4L1_ENST00000379535.4_Silent_p.Q266Q	NM_206839.2	NP_996670.1	Q9UBU8	MO4L1_HUMAN	mortality factor 4 like 1	280	Sufficient for interaction with PHF12.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding			breast(1)|large_intestine(3)|lung(4)|prostate(1)|urinary_tract(1)	10						AGAGACCACAGTATGCTGAAA	0.418000													59	124					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251415	25251415	+	Missense_Mutation	SNP	C	C	T	rs146263630	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:25251415C>T	ENST00000328086.7	-	7	3429	c.2626G>A	c.(2626-2628)Gcc>Acc	p.A876T		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	876					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		CTCCGGTGGGCGCTGAAATGA	0.453000													26	73					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129787023	129787023	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:129787023T>C	ENST00000358825.5	-	16	2567	c.2337_splice	c.e16+1	p.K779_splice	PRDM10_ENST00000528746.1_Splice_Site_p.K749_splice|PRDM10_ENST00000360871.3_Splice_Site_p.K775_splice|PRDM10_ENST00000423662.2_Splice_Site_p.K693_splice|PRDM10_ENST00000526082.1_Splice_Site_p.K693_splice|PRDM10_ENST00000304538.6_Splice_Site_p.K689_splice	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CCCTTTTACCTTATCGCAATA	0.378000													3	40					0	0	1	0	0
NAGPA	51172	broad.mit.edu	37	16	5083689	5083689	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:5083689C>T	ENST00000312251.3	-	2	146	c.127G>A	c.(127-129)Gcg>Acg	p.A43T	RP11-165E7.1_ENST00000588778.1_RNA|NAGPA_ENST00000381955.3_Missense_Mutation_p.A43T|NAGPA_ENST00000564922.1_5'UTR	NM_016256.3	NP_057340.2	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	43					carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity			endometrium(4)|large_intestine(4)|lung(3)|urinary_tract(1)	12					N-Acetyl-D-glucosamine(DB00141)	CGCGCGCGCGCGCGTGGATAG	0.761000													8	22					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30411359	30411359	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:30411359T>C	ENST00000375994.2	+	4	1125	c.852T>C	c.(850-852)agT>agC	p.S284S	MYLK2_ENST00000375985.4_Silent_p.S284S			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	284					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTGAATTCAGTATGAACTCCA	0.617000											OREG0025856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	152					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234580711	234580711	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:234580711T>C	ENST00000354728.4	+	1	213	c.131T>C	c.(130-132)gTg>gCg	p.V44A	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		ATGAGGTCGGTGGTGGAGAAA	0.537000													4	122					0	0	1	0	0
STAU1	6780	broad.mit.edu	37	20	47741121	47741121	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:47741121C>T	ENST00000371828.3	-	7	875	c.388G>A	c.(388-390)Gcc>Acc	p.A130T	STAU1_ENST00000340954.7_Missense_Mutation_p.A124T|STAU1_ENST00000371856.2_Missense_Mutation_p.A205T|STAU1_ENST00000347458.5_Missense_Mutation_p.A124T|STAU1_ENST00000360426.4_Missense_Mutation_p.A124T|STAU1_ENST00000371802.1_Missense_Mutation_p.A130T|STAU1_ENST00000371792.1_Missense_Mutation_p.A124T	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	205	DRBM 1.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			CTCTCCCGGGCCACCTGTTTC	0.517000													24	88					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20876530	20876530	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20876530A>G	ENST00000262715.5	-	2	109	c.69T>C	c.(67-69)gcT>gcC	p.A23A	TEP1_ENST00000556935.1_Silent_p.A23A	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	23					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGGGAGCATAGCCAGGCACC	0.512000													5	118					0	0	1	0	0
ACY1	95	broad.mit.edu	37	3	52022837	52022837	+	Missense_Mutation	SNP	C	C	T	rs121912698	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52022837C>T	ENST00000458031.2	+	16	1558	c.1327C>T	c.(1327-1329)Cgc>Tgc	p.R443C	ACY1_ENST00000494103.1_Missense_Mutation_p.R281C|ACY1_ENST00000404366.2_Missense_Mutation_p.R353C|ABHD14A-ACY1_ENST00000463937.1_Missense_Mutation_p.R454C|ACY1_ENST00000476854.1_Missense_Mutation_p.R288C|ACY1_ENST00000476351.1_Missense_Mutation_p.R318C			Q03154	ACY1_HUMAN	aminoacylase 1	353					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CCGCTATATCCGCGCGGTGAG	0.587000													91	254					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7044749	7044749	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:7044749A>G	ENST00000356654.4	+	5	556	c.319A>G	c.(319-321)Agc>Ggc	p.S107G	ATN1_ENST00000396684.2_Missense_Mutation_p.S107G	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	107					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						CGATCTGGATAGCTTGGACGG	0.542000													17	64					0	0	1	0	0
HSF4	3299	broad.mit.edu	37	16	67200484	67200484	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67200484A>G	ENST00000264009.8	+	8	1550	c.585A>G	c.(583-585)ccA>ccG	p.P195P	HSF4_ENST00000584272.1_Silent_p.P195P|HSF4_ENST00000421453.1_Silent_p.P195P|HSF4_ENST00000517867.1_3'UTR|HSF4_ENST00000521374.1_Silent_p.P195P	NM_001040667.2	NP_001035757.1	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4	195	Hydrophobic repeat HR-A/B.				response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		TCTTTGGGCCACTTCAGGCGG	0.562000													13	49					0	0	1	0	0
CD97	976	broad.mit.edu	37	19	14515304	14515304	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14515304A>G	ENST00000242786.5	+	13	1639	c.1559A>G	c.(1558-1560)aAc>aGc	p.N520S	CTC-548K16.5_ENST00000590626.1_RNA|CD97_ENST00000357355.3_Missense_Mutation_p.N471S|CD97_ENST00000358600.3_Missense_Mutation_p.N427S	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	520	GPS.				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GGCAGCAAGAACGGCAGCACC	0.622000													20	90					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105185138	105185138	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:105185138G>A	ENST00000330634.7	+	22	3844	c.3701G>A	c.(3700-3702)aGg>aAg	p.R1234K	INF2_ENST00000392634.4_3'UTR|INF2_ENST00000481338.1_3'UTR	NM_001031714.3	NP_001026884.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	1234					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		ACAGGCCTCAGGCCCAGGCCC	0.592000													10	22					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754868	49754868	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:49754868T>C	ENST00000304801.3	-	1	185	c.33A>G	c.(31-33)aaA>aaG	p.K11K		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	11					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TAACATCCAGTTTGTCTAAAG	0.418000													23	70					0	0	1	0	0
FAM186B	84070	broad.mit.edu	37	12	49993649	49993649	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49993649G>A	ENST00000544141.1	-	4	2103	c.1504C>T	c.(1504-1506)Cca>Tca	p.P502S	FAM186B_ENST00000257894.2_Missense_Mutation_p.P592S|FAM186B_ENST00000551047.1_Intron|PRPF40B_ENST00000508736.1_3'UTR			Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	592						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GGCAAGTGTGGCCTCCTGCTT	0.572000													23	79					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106876294	106876294	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:106876294T>C	ENST00000286398.7	+	12	1752	c.1464T>C	c.(1462-1464)gaT>gaC	p.D488D	SMC2_ENST00000374787.3_Silent_p.D488D|SMC2_ENST00000374793.3_Silent_p.D488D|SMC2_ENST00000303219.8_Silent_p.D488D	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	488					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						TGTCTCGTGATATTGGTAGAT	0.338000													4	229					0	0	1	0	0
PANK1	53354	broad.mit.edu	37	10	91404753	91404753	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:91404753T>C	ENST00000307534.4	-	1	462	c.307A>G	c.(307-309)Aat>Gat	p.N103D		NM_148977.2	NP_683878.1	Q8TE04	PANK1_HUMAN	pantothenate kinase 1	103					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity			cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	GGCTTCCGATTCAGCAGCCGC	0.746000													14	43					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65561892	65561892	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:65561892A>G	ENST00000356388.4	-	3	409	c.220T>C	c.(220-222)Tat>Cat	p.Y74H	SPRED2_ENST00000474228.1_5'UTR|SPRED2_ENST00000443619.2_Missense_Mutation_p.Y71H	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	74	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						TTTCTTACATAGCATTCCAAT	0.438000													4	148					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117280361	117280361	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:117280361G>A	ENST00000278935.3	+	30	3923	c.3776G>A	c.(3775-3777)cGc>cAc	p.R1259H	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1259					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CTCACCTCCCGCAAGATCCAC	0.612000													81	219					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76063224	76063224	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:76063224A>G	ENST00000260045.3	-	5	1075	c.970T>C	c.(970-972)Tat>Cat	p.Y324H		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	324					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						CCACGACAATACTCCATATTT	0.388000													41	114					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21826538	21826538	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21826538T>C	ENST00000216297.2	-	20	2688	c.2350A>G	c.(2350-2352)Att>Gtt	p.I784V		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	784					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		ACTTTCTCAATGAAATTTTTA	0.368000													6	72					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102054309	102054309	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:102054309C>T	ENST00000318222.3	-	9	2024	c.1642G>A	c.(1642-1644)Gtc>Atc	p.V548I	PKD2L1_ENST00000338519.3_Missense_Mutation_p.V473I|PKD2L1_ENST00000353274.3_Missense_Mutation_p.V548I	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	548					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		ACGAAGAAGACGAAGAAGACA	0.532000													28	86					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33933540	33933540	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:33933540T>C	ENST00000379238.1	-	18	2173	c.2056A>G	c.(2056-2058)Aca>Gca	p.T686A	UBAP2_ENST00000418786.2_Missense_Mutation_p.T633A|UBAP2_ENST00000360802.1_Missense_Mutation_p.T686A|UBAP2_ENST00000379239.4_Missense_Mutation_p.T419A|UBAP2_ENST00000449054.1_Missense_Mutation_p.T686A|UBAP2_ENST00000539807.1_Missense_Mutation_p.T441A			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	686										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGCTGGGATGTGGACGGCAGA	0.597000													17	47					0	0	1	0	0
CSNK2A2	1459	broad.mit.edu	37	16	58220736	58220736	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:58220736G>A	ENST00000262506.3	-	3	424	c.241C>T	c.(241-243)Cga>Tga	p.R81*	CSNK2A2_ENST00000566813.1_5'UTR	NM_001896.2	NP_001887.1	P19784	CSK22_HUMAN	casein kinase 2, alpha prime polypeptide	81	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|nucleus	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TTAACCTCTCGTTTTATCTTC	0.378000													23	79					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52448704	52448704	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:52448704A>G	ENST00000293471.6	+	6	2247	c.1568A>G	c.(1567-1569)cAc>cGc	p.H523R	ZNF613_ENST00000601794.1_3'UTR|ZNF613_ENST00000391794.4_Missense_Mutation_p.H487R	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	523					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		GCTTTCTCCCACTTGTCATGC	0.433000													26	63					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67263713	67263713	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67263713C>T	ENST00000258201.4	-	21	3642	c.3395G>A	c.(3394-3396)cGc>cAc	p.R1132H	FHOD1_ENST00000567687.1_Missense_Mutation_p.R711H	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1132					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GCGGTTGCCGCGGGAACGCTT	0.562000													49	153					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	285213	285213	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:285213C>T	ENST00000534750.1	+	8	2790	c.2585C>T	c.(2584-2586)gCt>gTt	p.A862V	NLRP6_ENST00000312165.5_Missense_Mutation_p.A863V	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	863						cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GAGCTTCAGGCTGTGAAGAGA	0.612000													3	12					0	0	1	0	0
ETF1	2107	broad.mit.edu	37	5	137848560	137848560	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:137848560C>T	ENST00000499810.2	-	6	974	c.526G>A	c.(526-528)Gct>Act	p.A176T	ETF1_ENST00000503014.1_Missense_Mutation_p.A195T|ETF1_ENST00000360541.5_Missense_Mutation_p.A209T			P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	209					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGCTGCACAGCAGTCTCTGCT	0.428000													35	90					0	0	1	0	0
TRIP6	7205	broad.mit.edu	37	7	100468203	100468203	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100468203T>C	ENST00000200457.4	+	6	1197	c.837T>C	c.(835-837)tgT>tgC	p.C279C		NM_003302.2	NP_003293.2	Q15654	TRIP6_HUMAN	thyroid hormone receptor interactor 6	279	LIM zinc-binding 1.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					CAGGCCAGTGTGGTGGCTGCG	0.612000													7	94					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43502557	43502557	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43502557G>A	ENST00000300215.3	-	5	1177	c.720C>T	c.(718-720)caC>caT	p.H240H	EPB42_ENST00000540029.1_Silent_p.H132H|EPB42_ENST00000441366.2_Silent_p.H210H			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	210					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CACGGGCCACGTGCACCGGCT	0.597000													54	120					0	0	1	0	0
TAB2	23118	broad.mit.edu	37	6	149691182	149691182	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:149691182C>T	ENST00000367456.1	+	3	626	c.49C>T	c.(49-51)Cga>Tga	p.R17*	TAB2_ENST00000536230.1_Intron|TAB2_ENST00000538427.1_Nonsense_Mutation_p.R17*|TAB2_ENST00000392282.1_Nonsense_Mutation_p.R17*|TAB2_ENST00000286332.5_Nonsense_Mutation_p.R17*			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	17	CUE.				activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						ACATGACCTGCGACAAAAATT	0.393000													8	71					0	0	1	0	0
C16orf45	89927	broad.mit.edu	37	16	15609245	15609245	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:15609245C>T	ENST00000300006.4	+	2	549	c.190C>T	c.(190-192)Cgg>Tgg	p.R64W	C16orf45_ENST00000452191.2_Missense_Mutation_p.R47W|C16orf45_ENST00000561692.1_Missense_Mutation_p.R16W|C16orf45_ENST00000566490.1_Missense_Mutation_p.R64W	NM_033201.2	NP_149978.1	Q96MC5	CP045_HUMAN	chromosome 16 open reading frame 45	64								p.R64fs*6(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)	11						TCAGCGTCTCCGGGAAGTCTT	0.527000													13	41					0	0	1	0	0
SERPINB5	5268	broad.mit.edu	37	18	61154286	61154286	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:61154286C>T	ENST00000382771.4	+	3	568	c.276C>T	c.(274-276)ctC>ctT	p.L92L	SERPINB5_ENST00000489441.1_Silent_p.L92L	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	92					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						TCAAGCGGCTCTACGTAGACA	0.348000													16	56					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81053160	81053160	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:81053160A>G	ENST00000334512.5	+	12	1552	c.980A>G	c.(979-981)aAc>aGc	p.N327S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	327					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CAGGCGTATAACAGCCAATTC	0.577000													6	315					0	0	1	0	0
NDUFA1	4694	broad.mit.edu	37	X	119007336	119007336	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:119007336G>A	ENST00000371437.4	+	2	597	c.172G>A	c.(172-174)Gat>Aat	p.D58N		NM_004541.3	NP_004532.1	O15239	NDUA1_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	58					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|large_intestine(2)|stomach(1)	5					NADH(DB00157)	CTCTGGAGTTGATCGTTACTA	0.453000													4	62					0	0	1	0	0
TAP1	6890	broad.mit.edu	37	6	32819972	32819972	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32819972A>G	ENST00000354258.4	-	3	1099	c.938T>C	c.(937-939)aTg>aCg	p.M313T	TAP1_ENST00000425148.2_Missense_Mutation_p.M52T|PSMB9_ENST00000395330.1_Intron	NM_000593.5	NP_000584.2	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	313	ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(4)|prostate(1)|skin(1)	21						CACGTGGCCCATGGTGTTGTT	0.532000													11	99					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4874654	4874654	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:4874654G>A	ENST00000399583.3	-	4	1187	c.1000C>T	c.(1000-1002)Cac>Tac	p.H334Y	RADIL_ENST00000536091.1_Missense_Mutation_p.H334Y|RADIL_ENST00000538469.1_Missense_Mutation_p.H94Y	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	334	FHA.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		ACGGTCCTGTGCCCCACCTCG	0.726000													11	22					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94745947	94745947	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:94745947A>G	ENST00000399300.2	-	3	2905	c.2692T>C	c.(2692-2694)Ttt>Ctt	p.F898L	RP11-10N23.4_ENST00000517998.1_RNA|RBM12B_ENST00000517700.1_Missense_Mutation_p.F778L|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	898							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TGCTTTCCAAAATCAAACTTG	0.408000													79	375					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101921271	101921271	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:101921271A>G	ENST00000437600.4	+	18	1961	c.1609A>G	c.(1609-1611)Agc>Ggc	p.S537G	CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000425244.2_Missense_Mutation_p.S493G|CUX1_ENST00000393824.3_Missense_Mutation_p.S500G|CUX1_ENST00000547394.2_Missense_Mutation_p.S523G|CUX1_ENST00000292538.4_Missense_Mutation_p.S539G	NM_181500.2	NP_852477.1	P39880	CUX1_HUMAN	cut-like homeobox 1	347					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TGAGCTGGACAGCCTGCGCGC	0.667000													5	17					0	0	1	0	0
KLHL34	257240	broad.mit.edu	37	X	21674052	21674052	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:21674052C>T	ENST00000379499.2	-	1	2396	c.1855G>A	c.(1855-1857)Gca>Aca	p.A619T		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	619										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						TGCAGCACTGCGCACCGCAGG	0.667000													20	10					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238728941	238728941	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:238728941C>T	ENST00000316997.4	+	5	1995	c.1863C>T	c.(1861-1863)cgC>cgT	p.R621R	RBM44_ENST00000409864.1_Silent_p.R621R|RBM44_ENST00000444524.2_3'UTR	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	620							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TGTGTCGTCGCCATTGTTGTG	0.353000													4	22					0	0	1	0	0
ZBTB39	9880	broad.mit.edu	37	12	57397891	57397891	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:57397891T>C	ENST00000300101.2	-	2	896	c.811A>G	c.(811-813)Act>Gct	p.T271A		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						TTGGTCCCAGTGGTAATGTCT	0.517000													39	132					0	0	1	0	0
ZBTB24	9841	broad.mit.edu	37	6	109787184	109787184	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:109787184G>A	ENST00000230122.3	-	7	2131	c.1964C>T	c.(1963-1965)aCa>aTa	p.T655I		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	655					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		GAGCTCCTCTGTTTGCTCTTG	0.542000													21	71					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89603315	89603315	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:89603315C>T	ENST00000341316.2	+	10	1474	c.1467C>T	c.(1465-1467)caC>caT	p.H489H	SPG7_ENST00000268704.2_Intron	NM_199367.1	NP_955399.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	0					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GCCTTTTGCACTGAAGATAGA	0.527000													58	213					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31338232	31338232	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:31338232A>G	ENST00000215862.4	-	8	1630	c.267T>C	c.(265-267)aaT>aaC	p.N89N	MORC2_ENST00000469915.1_5'UTR|MORC2_ENST00000397641.2_Silent_p.N151N	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	151							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						GGGTCCGAGCATTCCAGGTGG	0.498000													8	213					0	0	1	0	0
GABRR3	200959	broad.mit.edu	37	3	97731363	97731363	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:97731363G>A	ENST00000472788.1	-	0	356					NM_001105580.2	NP_001099050.1	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 3						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			large_intestine(2)|lung(1)	3						GGAAAGGAGAGCCTCTCGTCT	0.393000													28	48					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61525511	61525511	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:61525511T>C	ENST00000266070.4	-	12	2933	c.2608A>G	c.(2608-2610)Aaa>Gaa	p.K870E	DIDO1_ENST00000395335.2_Missense_Mutation_p.K870E|DIDO1_ENST00000395343.1_Missense_Mutation_p.K870E|DIDO1_ENST00000395340.1_Missense_Mutation_p.K870E	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	870					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TTTTGTTTTTTCGGAGCTGGC	0.493000													61	182					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120300189	120300189	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:120300189T>C	ENST00000397843.2	+	9	792	c.626T>C	c.(625-627)cTg>cCg	p.L209P	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.L190P|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.L106P	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	209					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GTAGAAATTCTGAGAAAAATG	0.343000			T	MLL	AML								20	62					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107155231	107155231	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:107155231C>T	ENST00000392842.1	+	18	2606	c.2192C>T	c.(2191-2193)aCa>aTa	p.T731I	RFX4_ENST00000229387.5_Missense_Mutation_p.T637I|RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000357881.4_Missense_Mutation_p.T740I	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	731					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GAGGCCTCTACAGGATGGGCT	0.388000													12	40					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48654515	48654515	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:48654515G>A	ENST00000263274.7	-	7	967	c.548C>T	c.(547-549)aCg>aTg	p.T183M	LIG1_ENST00000536218.1_Intron|LIG1_ENST00000427526.2_Missense_Mutation_p.T152M|LIG1_ENST00000599165.1_5'UTR	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	183					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CTTGGGAGGCGTGGTGGGCTG	0.567000								Nucleotide excision repair (NER)					52	167					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70464697	70464697	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:70464697G>A	ENST00000373998.1	-	19	3715	c.3018C>T	c.(3016-3018)ggC>ggT	p.G1006G	ZMYM3_ENST00000314425.5_Silent_p.G1018G|ZMYM3_ENST00000373988.1_Silent_p.G1020G|ZMYM3_ENST00000353904.2_Silent_p.G1018G|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373984.3_Silent_p.G1020G	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1018					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					GCCCTACCAGGCCACAATCAA	0.458000													6	3					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179439851	179439851	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179439851C>T	ENST00000589042.1	-	326	71232	c.71008G>A	c.(71008-71010)Gga>Aga	p.G23670R	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G14605R|TTN_ENST00000342992.6_Missense_Mutation_p.G21102R|TTN_ENST00000591111.1_Missense_Mutation_p.G22029R|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G14730R|TTN_ENST00000342175.6_Missense_Mutation_p.G14797R|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22029	Fibronectin type-III 72.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTGGTCTCCTTTTTTCCAT	0.423000													10	18					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111580270	111580270	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:111580270T>C	ENST00000428084.1	-	11	1144	c.872A>G	c.(871-873)aAt>aGt	p.N291S	DOCK4_ENST00000476846.1_5'UTR|DOCK4_ENST00000437633.1_Missense_Mutation_p.N291S			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	291					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				ACTACAGGCATTCTTTTTTTC	0.443000													48	142					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43980807	43980807	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:43980807C>T	ENST00000282406.4	+	25	3813	c.3703C>T	c.(3703-3705)Ctg>Ttg	p.L1235L		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1235	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGAAAAGTTGCTGTTAATGTA	0.323000													4	118					0	0	1	0	0
CREB3L1	90993	broad.mit.edu	37	11	46332639	46332639	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:46332639G>A	ENST00000529193.1	+	5	1103	c.652G>A	c.(652-654)Ggc>Agc	p.G218S	CREB3L1_ENST00000288400.3_Missense_Mutation_p.G218S			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	218					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		TGACAGCGACGGCTCCCAGAG	0.672000			T	FUS	myxofibrosarcoma								37	74					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42147810	42147810	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:42147810C>T	ENST00000320955.6	-	54	9382	c.9155G>A	c.(9154-9156)aGc>aAc	p.S3052N		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3052					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GATGCGTGGGCTGAACGCTTC	0.637000													4	30					0	0	1	0	0
AP1S1	1174	broad.mit.edu	37	7	100799968	100799968	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100799968C>T	ENST00000337619.5	+	2	215	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C		NM_001283.3	NP_001274.1	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1 subunit	33					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)	8	Lung NSC(181;0.168)|all_lung(186;0.215)					GAAGATGGTGCGCGAGCTCAT	0.542000													9	20					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73442894	73442894	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:73442894T>C	ENST00000377110.2	-	6	1085	c.842A>G	c.(841-843)aAg>aGg	p.K281R	TRPM3_ENST00000357533.2_Missense_Mutation_p.K283R|TRPM3_ENST00000396292.4_Missense_Mutation_p.K128R|TRPM3_ENST00000396285.1_Missense_Mutation_p.K128R|TRPM3_ENST00000396283.1_Missense_Mutation_p.K128R|TRPM3_ENST00000396280.5_Missense_Mutation_p.K128R|TRPM3_ENST00000360823.2_Missense_Mutation_p.K128R|TRPM3_ENST00000408909.2_Missense_Mutation_p.K128R|TRPM3_ENST00000377101.1_Missense_Mutation_p.K128R|TRPM3_ENST00000423814.3_Missense_Mutation_p.K283R|TRPM3_ENST00000377111.2_Missense_Mutation_p.K281R|TRPM3_ENST00000377106.1_Missense_Mutation_p.K128R|TRPM3_ENST00000358082.3_Missense_Mutation_p.K128R|TRPM3_ENST00000361823.5_Missense_Mutation_p.K128R|TRPM3_ENST00000377105.1_Missense_Mutation_p.K128R	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	281						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AACAGTGAGCTTGCTCATGGG	0.463000													8	184					0	0	1	0	0
IFNGR2	3460	broad.mit.edu	37	21	34793935	34793935	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:34793935C>G	ENST00000290219.6	+	3	1003	c.355C>G	c.(355-357)Ctg>Gtg	p.L119V	IFNGR2_ENST00000405436.1_Missense_Mutation_p.L40V|IFNGR2_ENST00000381995.1_Missense_Mutation_p.L138V	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	119	Fibronectin type-III 1.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	TCGAGCTGAGCTGGGAGCACT	0.483000													43	149					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32328785	32328785	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:32328785A>T	ENST00000375200.1	+	2	474	c.109A>T	c.(109-111)Agt>Tgt	p.S37C	ZNF341_ENST00000342427.2_Missense_Mutation_p.S37C			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GACAGGCCAGAGTGTCAATGC	0.552000													6	104					0	0	1	0	0
SLC30A6	55676	broad.mit.edu	37	2	32400414	32400414	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:32400414A>G	ENST00000282587.5	+	4	239	c.202A>G	c.(202-204)Att>Gtt	p.I68V	SLC30A6_ENST00000406369.1_Intron|SLC30A6_ENST00000379343.2_Missense_Mutation_p.I68V|SLC30A6_ENST00000357055.3_Intron|SLC30A6_ENST00000538303.1_Missense_Mutation_p.I39V|SLC30A6_ENST00000435660.1_Missense_Mutation_p.I68V	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	68						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTACCTGACCATTTTTGATCT	0.299000													17	18					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120585045	120585045	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120585045C>T	ENST00000300648.6	-	38	4770	c.4758G>A	c.(4756-4758)acG>acA	p.T1586T		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1586					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGAGGGATCCGTCAGGGCAT	0.567000													26	47					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1802636	1802636	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1802636T>C	ENST00000539485.1	-	11	1146	c.913A>G	c.(913-915)Acg>Gcg	p.T305A	ATP8B3_ENST00000526092.1_Missense_Mutation_p.T252A|ATP8B3_ENST00000525591.1_Missense_Mutation_p.T252A|ATP8B3_ENST00000310127.6_Missense_Mutation_p.T305A			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	305					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCACACGTCACTGTGCCT	0.617000													6	26					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31676817	31676817	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:31676817C>T	ENST00000375483.3	+	6	972	c.972C>T	c.(970-972)gcC>gcT	p.A324A		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	324						cytoplasm|extracellular region	lipid binding										GAGTCCTGGCCGACGTCCTCC	0.597000													41	164					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57415854	57415854	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:57415854G>A	ENST00000313949.7	+	1	1082	c.693G>A	c.(691-693)ccG>ccA	p.P231P	GNAS_ENST00000371075.3_Silent_p.P231P|GNAS-AS1_ENST00000424094.2_RNA|GNAS_ENST00000371098.2_Silent_p.P231P|GNAS-AS1_ENST00000443966.1_RNA|GNAS-AS1_ENST00000598163.1_RNA			P63092	GNAS2_HUMAN	GNAS complex locus	326			R -> H (in AHO; impairs the ability to mediate hormonal stimulation).		activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			ACGCGTCCCCGGAGTCCCCTT	0.592000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			9	31					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575315	136575315	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:136575315T>C	ENST00000264162.2	-	6	1313	c.1303A>G	c.(1303-1305)Aag>Gag	p.K435E		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	435	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGGCTACCTTGTGGTAACTG	0.652000													40	109					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24563208	24563208	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:24563208G>A	ENST00000398319.2	+	32	5994	c.5609G>A	c.(5608-5610)gGc>gAc	p.G1870D	CABIN1_ENST00000337989.7_Missense_Mutation_p.G295D|CABIN1_ENST00000485008.1_3'UTR|CABIN1_ENST00000263119.5_Missense_Mutation_p.G1870D|CABIN1_ENST00000405822.2_Missense_Mutation_p.G1791D	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1870					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TGGCAGCAGGGCCAGAAGGGT	0.627000													10	34					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145758541	145758541	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145758541G>A	ENST00000276826.5	-	7	2965	c.2764C>T	c.(2764-2766)Ctc>Ttc	p.L922F	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.L953F|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.L922F			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	922	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TCACCGTTGAGCGCCAGCACC	0.672000													5	181					0	0	1	0	0
TOX4	9878	broad.mit.edu	37	14	21960674	21960674	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21960674T>C	ENST00000405508.1	+	8	1175	c.899T>C	c.(898-900)gTg>gCg	p.V300A	TOX4_ENST00000262709.3_Missense_Mutation_p.V300A|TOX4_ENST00000448790.2_Missense_Mutation_p.V277A			O94842	TOX4_HUMAN	TOX high mobility group box family member 4	300						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		TAGGCCACTGTGGAAACAGTG	0.408000													10	195					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241692	60241692	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:60241692T>C	ENST00000269499.5	+	13	2796	c.2378T>C	c.(2377-2379)tTa>tCa	p.L793S	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.L472S	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	793					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GCTTCCCCTTTACCTATTCCA	0.488000													9	89					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7288935	7288935	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:7288935C>T	ENST00000537408.1	+	5	1450	c.912C>T	c.(910-912)gcC>gcT	p.A304A	CLSTN3_ENST00000266546.6_Silent_p.A292A			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	292					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GCCATGTGGCCAAGGGCTGTG	0.587000													14	63					0	0	1	0	0
ATP1B3	483	broad.mit.edu	37	3	141622465	141622465	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:141622465T>C	ENST00000539728.1	+	3	364	c.71T>C	c.(70-72)tTg>tCg	p.L24S	ATP1B3_ENST00000286371.3_Missense_Mutation_p.L38S|ATP1B3_ENST00000462082.1_5'UTR			P54709	AT1B3_HUMAN	ATPase, Na+/K+ transporting, beta 3 polypeptide	38					ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			cervix(1)|endometrium(1)|lung(2)	4						TTTACAGGTTTGATCTTGCTC	0.408000													15	49					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117124719	117124719	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:117124719G>T	ENST00000307564.4	-	8	2044	c.1883C>A	c.(1882-1884)tCc>tAc	p.S628Y	AKNA_ENST00000223791.3_Missense_Mutation_p.S88Y|AKNA_ENST00000374088.3_Missense_Mutation_p.S628Y|AKNA_ENST00000312033.3_Missense_Mutation_p.S628Y|AKNA_ENST00000374075.5_Missense_Mutation_p.S547Y	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	628					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CGTCCCCTTGGAGCCGGCAAG	0.647000													8	23					0.000274275	0.00027791	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228400338	228400338	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:228400338T>C	ENST00000570156.2	+	2	928	c.854T>C	c.(853-855)gTg>gCg	p.V285A	OBSCN_ENST00000422127.1_Missense_Mutation_p.V285A|C1orf145_ENST00000295012.5_Intron|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.V285A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	285	Ig-like 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGGCGCCACGTGGTGTACGAG	0.672000													26	104					0	0	1	0	0
FZD8	8325	broad.mit.edu	37	10	35929076	35929076	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:35929076T>C	ENST00000374694.1	-	1	1286	c.1282A>G	c.(1282-1284)Aag>Gag	p.K428E		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	428					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						TTGCCCCACTTCATACCGGCC	0.622000													13	23					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101840288	101840288	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:101840288G>C	ENST00000360264.3	+	15	1650	c.1630G>C	c.(1630-1632)Gcc>Ccc	p.A544P	CUX1_ENST00000556210.1_Missense_Mutation_p.A431P|CUX1_ENST00000549414.2_Missense_Mutation_p.A533P|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000550008.2_Missense_Mutation_p.A533P|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000546411.2_Missense_Mutation_p.A431P|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000292535.7_Missense_Mutation_p.A533P	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	533					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CAATGGCATGGCCCCATCCCC	0.522000													7	157					0	0	1	0	0
SCGB3A2	117156	broad.mit.edu	37	5	147261109	147261109	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:147261109T>C	ENST00000296694.4	+	2	249	c.156T>C	c.(154-156)ctT>ctC	p.L52L	SCGB3A2_ENST00000504320.1_Silent_p.L7L|C5orf46_ENST00000510432.1_Intron|SCGB3A2_ENST00000514688.1_3'UTR	NM_054023.4	NP_473364.1	Q96PL1	SG3A2_HUMAN	secretoglobin, family 3A, member 2	52						extracellular region	binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAAGCTTCTTCTGAAAACTC	0.473000													38	111					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47704204	47704204	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47704204G>A	ENST00000397708.1	-	2	1251	c.997C>T	c.(997-999)Cgg>Tgg	p.R333W	MCM3AP_ENST00000291688.1_Missense_Mutation_p.R333W			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	333			R -> L (in dbSNP:rs17182552).		DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					GTACCTCCCCGGGGTCGATTC	0.537000													42	160					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197687215	197687215	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:197687215A>G	ENST00000330198.4	+	1	145	c.123A>G	c.(121-123)ttA>ttG	p.L41L	LMLN_ENST00000482695.1_Intron|LMLN_ENST00000420910.2_Silent_p.L41L|LMLN_ENST00000332636.5_Intron	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	41					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GAAGCGTTTTACTCCTGTTGG	0.687000													4	158					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36597387	36597387	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:36597387A>T	ENST00000299440.5	+	2	2645	c.2533A>T	c.(2533-2535)Aac>Tac	p.N845Y		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	845					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GAAGAAGATGAACCTCAAACC	0.473000									Familial Hemophagocytic Lymphohistiocytosis				17	59					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139165179	139165179	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:139165179C>T	ENST00000395297.1	-	13	1709	c.1539G>A	c.(1537-1539)gtG>gtA	p.V513V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	513								p.V513V(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CATCTTCAGGCACACCTGCTT	0.458000										HNSCC(54;0.14)			9	150					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17275411	17275411	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17275411G>T	ENST00000375541.5	+	19	2895	c.2826G>T	c.(2824-2826)gaG>gaT	p.E942D	CROCC_ENST00000467938.1_Intron	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	942					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TGGCCAAGGAGACCCTGACTG	0.667000													13	53					6.72482e-11	6.97693e-11	1	1	0
DLX5	1749	broad.mit.edu	37	7	96650052	96650052	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:96650052T>C	ENST00000222598.4	-	3	1339	c.866A>G	c.(865-867)tAt>tGt	p.Y289C	DLX5_ENST00000493764.1_5'UTR	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	289					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GCCCATCTAATAGAGTGTCCC	0.507000													12	63					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21242847	21242847	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:21242847C>G	ENST00000540229.1	+	16	2119	c.2054C>G	c.(2053-2055)gCc>gGc	p.A685G	LST3_ENST00000381541.3_Missense_Mutation_p.A624G|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.A577G|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.A624G|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.A685G|RP11-125O5.2_ENST00000590779.1_Intron																							CACAGAAGAGCCTTCTTCGGC	0.294000													6	36					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139905674	139905674	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139905674A>G	ENST00000265662.5	-	38	6034	c.5887T>C	c.(5887-5889)Tac>Cac	p.Y1963H	ABCA2_ENST00000341511.6_Missense_Mutation_p.Y1963H|ABCA2_ENST00000371605.3_Missense_Mutation_p.Y1962H			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1962					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TACTCGTTGTAGGCCATCTCC	0.617000													4	91					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46662488	46662488	+	Missense_Mutation	SNP	C	C	T	rs139701867	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:46662488C>T	ENST00000396420.3	-	4	905	c.269G>A	c.(268-270)cGc>cAc	p.R90H	POMGNT1_ENST00000371986.3_Missense_Mutation_p.R90H|POMGNT1_ENST00000371992.1_Missense_Mutation_p.R90H|POMGNT1_ENST00000371984.3_Missense_Mutation_p.R90H|POMGNT1_ENST00000535522.1_Missense_Mutation_p.R68H			Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	90					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					ACTGCCTCTGCGCCGTGGGGG	0.622000													38	125					0	0	1	0	0
C16orf58	64755	broad.mit.edu	37	16	31508199	31508199	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:31508199C>T	ENST00000327237.2	-	6	712	c.673G>A	c.(673-675)Gct>Act	p.A225T	C16orf58_ENST00000567994.1_Missense_Mutation_p.A180T|C16orf58_ENST00000570164.1_Missense_Mutation_p.A225T|C16orf58_ENST00000430477.2_Missense_Mutation_p.A83T			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	225						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						GACACGTCAGCCATGTTGTTC	0.642000													3	26					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155172668	155172668	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:155172668A>G	ENST00000368378.3	-	8	912	c.892T>C	c.(892-894)Tac>Cac	p.Y298H	RP11-263K19.4_ENST00000422665.1_RNA|THBS3_ENST00000428962.2_Missense_Mutation_p.Y148H|RP11-263K19.4_ENST00000430312.1_RNA|THBS3_ENST00000541990.1_5'UTR|RP11-263K19.4_ENST00000453136.1_RNA|THBS3_ENST00000457183.2_Missense_Mutation_p.Y178H|THBS3_ENST00000487250.1_5'UTR	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	298	EGF-like 1.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCACAGCGGTAGCCTGGGTAC	0.617000													19	77					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1648678	1648678	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1648678T>C	ENST00000324015.3	+	4	231	c.154T>C	c.(154-156)Ttg>Ctg	p.L52L	SERPINF2_ENST00000450523.2_Silent_p.L52L|SERPINF2_ENST00000382061.4_Silent_p.L52L	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	52					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	CCTCCTCAAGTTGGGCAACCA	0.672000													25	63					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17629211	17629211	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:17629211T>C	ENST00000262077.2	-	18	3218	c.3219A>G	c.(3217-3219)gaA>gaG	p.E1073E	NUP153_ENST00000537253.1_Silent_p.E1104E	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	1073					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			CAGGCATTTCTTCTTTTTTAG	0.468000													30	88					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498630	179498630	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179498630T>C	ENST00000589042.1	-	231	42820	c.42596A>G	c.(42595-42597)gAa>gGa	p.E14199G	TTN_ENST00000460472.2_Missense_Mutation_p.E5134G|TTN_ENST00000342992.6_Missense_Mutation_p.E11631G|TTN_ENST00000591111.1_Missense_Mutation_p.E12558G|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E5259G|TTN_ENST00000342175.6_Missense_Mutation_p.E5326G|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12558	Fibronectin type-III 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTTCATTTCCAATTTGTG	0.398000													9	236					0	0	1	0	0
TXN	7295	broad.mit.edu	37	9	113006438	113006438	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:113006438T>C	ENST00000374517.5	-	5	521	c.317A>G	c.(316-318)tAa>tGa	p.*106*	TXN_ENST00000374515.5_Silent_p.*86*|TXN_ENST00000487892.1_5'UTR	NM_003329.3	NP_003320.2	P10599	THIO_HUMAN	thioredoxin	0					cell proliferation|cell-cell signaling|cellular component movement|electron transport chain|glycerol ether metabolic process|nucleobase, nucleoside and nucleotide interconversion|positive regulation of DNA binding|regulation of protein import into nucleus, translocation|response to radiation|signal transduction|transcription, DNA-dependent|transport	cytosol|extracellular region|nucleoplasm	electron carrier activity|protein binding|protein disulfide oxidoreductase activity			kidney(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(323;7.36e-07)		AAAACATGATTAGACTAATTC	0.308000													4	19					0	0	1	0	0
BAG1	573	broad.mit.edu	37	9	33255240	33255240	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:33255240T>C	ENST00000472232.3	-	7	1101	c.1015A>G	c.(1015-1017)Aca>Gca	p.T339A	BAG1_ENST00000467389.2_5'UTR|BAG1_ENST00000379704.2_Missense_Mutation_p.T224A	NM_001172415.1|NM_004323.5	NP_001165886.1|NP_004314.5	Q99933	BAG1_HUMAN	BCL2-associated athanogene	339	Interaction with PPP1R15A.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(29;0.00506)			GCAAAGTTTGTAGACTGCAGC	0.562000													39	111					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39500223	39500223	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:39500223C>T	ENST00000518318.2	+	9	1522	c.1480C>T	c.(1480-1482)Cgg>Tgg	p.R494W	POU6F2_ENST00000559001.1_Missense_Mutation_p.R439W|POU6F2_ENST00000403058.1_Missense_Mutation_p.R494W			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	494	POU-specific.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						TTTTAAAATCCGGCGCCTGTC	0.552000													3	19					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152683313	152683313	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:152683313T>C	ENST00000367255.5	-	64	10892	c.10291A>G	c.(10291-10293)Aaa>Gaa	p.K3431E	SYNE1_ENST00000423061.1_Missense_Mutation_p.K3438E|SYNE1_ENST00000448038.1_Missense_Mutation_p.K3438E|SYNE1_ENST00000265368.4_Missense_Mutation_p.K3431E|SYNE1_ENST00000341594.5_Missense_Mutation_p.K3450E	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3431					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACCTTGGCTTTTCCGAGCATC	0.478000										HNSCC(10;0.0054)			5	79					0	0	1	0	0
KCTD4	386618	broad.mit.edu	37	13	45768564	45768564	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:45768564G>C	ENST00000405872.1	-	2	542	c.139C>G	c.(139-141)Caa>Gaa	p.Q47E	KCTD4_ENST00000379108.1_Missense_Mutation_p.Q47E|GTF2F2_ENST00000340473.6_Intron	NM_198404.2	NP_940686.2	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerization domain containing 4	47	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		GTTTGTTTTTGAGTAATGTAT	0.398000													60	179					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123089855	123089855	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123089855A>G	ENST00000333479.7	+	51	5566	c.5389A>G	c.(5389-5391)Att>Gtt	p.I1797V	KNTC1_ENST00000436959.3_5'UTR|KNTC1_ENST00000537348.1_Missense_Mutation_p.I222V|KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1797					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TATCTTAGATATTCATGCAGC	0.289000													5	15					0	0	1	0	0
HP	3240	broad.mit.edu	37	16	72093018	72093018	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:72093018T>C	ENST00000355906.5	+	6	431	c.373T>C	c.(373-375)Tac>Cac	p.Y125H	HP_ENST00000570083.1_Missense_Mutation_p.Y66H|HP_ENST00000569639.1_Missense_Mutation_p.Y66H|HPR_ENST00000356967.5_Intron|HP_ENST00000398131.2_Missense_Mutation_p.Y66H|HP_ENST00000565574.1_Intron|HP_ENST00000562526.1_Missense_Mutation_p.Y66H	NM_005143.3	NP_005134.1	P00738	HPT_HUMAN	haptoglobin	125	Sushi 2.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		TTCAGGAGTGTACACCTTAAA	0.443000													16	63					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3949808	3949808	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:3949808C>T	ENST00000281228.8	-	0	475				FAM86EP_ENST00000313946.8_RNA																							CCCTGCGCCCCGAGGTCACCT	0.637000													14	59					0	0	1	0	0
ZNF524	147807	broad.mit.edu	37	19	56113819	56113819	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56113819A>G	ENST00000591046.1	+	1	575	c.341A>G	c.(340-342)cAc>cGc	p.H114R	ZNF524_ENST00000301073.3_Missense_Mutation_p.H114R			Q96C55	ZN524_HUMAN	zinc finger protein 524	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AAGGCCCCACACTTCTGCCCG	0.647000													7	17					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116574133	116574133	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:116574133C>T	ENST00000369503.4	+	6	1005	c.875C>T	c.(874-876)aCt>aTt	p.T292I	SLC22A15_ENST00000369502.1_3'UTR	NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	292					ion transport	integral to membrane	transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGCAGGGAGACTGGAAGTTTC	0.498000													4	128					0	0	1	0	0
POLR2M	81488	broad.mit.edu	37	15	58004192	58004192	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:58004192C>T	ENST00000299638.3	+	3	983	c.769C>T	c.(769-771)Cga>Tga	p.R257*	GCOM1_ENST00000484300.1_3'UTR|POLR2M_ENST00000380557.4_Nonsense_Mutation_p.R100*|POLR2M_ENST00000380563.2_Nonsense_Mutation_p.R257*|GCOM1_ENST00000587652.1_Nonsense_Mutation_p.R654*|GCOM1_ENST00000380568.3_Intron|GCOM1_ENST00000380569.2_Nonsense_Mutation_p.R439*	NM_015532.3	NP_056347.1			polymerase (RNA) II (DNA directed) polypeptide M																		GTTACCTTTTCGACAAAATGA	0.398000													16	50					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108381121	108381121	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:108381121T>C	ENST00000265843.4	-	6	5223	c.5113A>G	c.(5113-5115)Aac>Gac	p.N1705D	EXPH5_ENST00000428840.1_Missense_Mutation_p.N1629D|EXPH5_ENST00000443411.1_Missense_Mutation_p.N1517D|EXPH5_ENST00000525344.1_Missense_Mutation_p.N1698D	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1705					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCTGAGACGTTTTTAAACTCA	0.433000													20	183					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573530	140573530	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140573530C>T	ENST00000239446.4	+	1	1589	c.1405C>T	c.(1405-1407)Cac>Tac	p.H469Y		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		469	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCGCCCTGCACATCGGCAG	0.652000													71	349					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30408420	30408420	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:30408420G>A	ENST00000333027.3	+	13	1513	c.1185G>A	c.(1183-1185)gcG>gcA	p.A395A	MTMR3_ENST00000323630.5_Silent_p.A259A|MTMR3_ENST00000406629.1_Silent_p.A395A|MTMR3_ENST00000401950.2_Silent_p.A395A|MTMR3_ENST00000351488.3_Silent_p.A395A|CTA-85E5.10_ENST00000429350.1_RNA	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	395	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TGAAATCAGCGCTTCTGGTAG	0.493000													94	239					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89589132	89589132	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:89589132T>C	ENST00000402738.1	+	14	1772	c.1533T>C	c.(1531-1533)ccT>ccC	p.P511P	HERC3_ENST00000543130.1_Intron|HERC3_ENST00000264345.3_Silent_p.P511P	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	511					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TAATACTACCTGAGTTTCCCC	0.418000													39	116					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088668	9088668	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9088668T>C	ENST00000397910.4	-	1	3350	c.3147A>G	c.(3145-3147)gaA>gaG	p.E1049E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1049	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAATCTTCCTTCAGTAATGT	0.468000													28	105					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940348	144940348	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144940348G>A	ENST00000525985.1	-	2	7145	c.7074C>T	c.(7072-7074)ccC>ccT	p.P2358P				P58107	EPIPL_HUMAN	epiplakin 1	2358						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCACGTCCACGGGCACGCGGT	0.692000													35	767					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673611	44673611	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44673611C>T	ENST00000454036.1	+	12	1546	c.1470C>T	c.(1468-1470)ggC>ggT	p.G490G	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Silent_p.G467G	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	490					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity	p.G467G(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCAGGTTTGGCGAAGCTGTGA	0.567000													45	167					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75277428	75277428	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:75277428G>A	ENST00000339859.4	-	19	2856	c.2756C>T	c.(2755-2757)gCc>gTc	p.A919V	USP54_ENST00000497106.1_5'UTR|RP11-137L10.6_ENST00000597958.1_RNA|RP11-137L10.6_ENST00000600206.1_RNA|RP11-137L10.6_ENST00000593790.1_RNA|USP54_ENST00000428547.1_Missense_Mutation_p.A769V|USP54_ENST00000422491.2_Missense_Mutation_p.A101V|USP54_ENST00000408019.1_Missense_Mutation_p.A919V|USP54_ENST00000394811.2_Missense_Mutation_p.A7V|RP11-137L10.6_ENST00000595069.1_RNA			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	919					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					GAAAGAACTGGCCCCAAACTC	0.517000													24	54					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8829566	8829566	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:8829566C>T	ENST00000567812.1	+	2	277	c.15C>T	c.(13-15)caC>caT	p.H5H	ABAT_ENST00000268251.8_5'UTR|ABAT_ENST00000396600.2_5'UTR|ABAT_ENST00000425191.2_5'UTR|ABAT_ENST00000569156.1_5'UTR			P80404	GABT_HUMAN	4-aminobutyrate aminotransferase	0					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	26					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	GGTGGCAGCACGCAAAGGGTG	0.597000													3	5					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157804402	157804402	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:157804402G>A	ENST00000368174.4	-	4	609	c.513C>T	c.(511-513)gcC>gcT	p.A171A		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	171	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCACCTTTGCGGCCCGGAGGC	0.612000													35	133					0	0	1	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19316155	19316155	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:19316155T>C	ENST00000454498.2	-	5	1648		c.e5-2		CSGALNACT1_ENST00000332246.6_Splice_Site|CSGALNACT1_ENST00000311540.4_Splice_Site|CSGALNACT1_ENST00000518542.1_Splice_Site|CSGALNACT1_ENST00000522854.1_Splice_Site|CSGALNACT1_ENST00000544602.1_Splice_Site	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1						anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		GGTAGATCCCTGTTAAGAGAA	0.398000													50	148					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584602	138584602	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:138584602A>G	ENST00000251691.4	+	12	2148	c.1982A>G	c.(1981-1983)aAa>aGa	p.K661R		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	661	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTGTCTCTAAAACTGCTGAAG	0.592000													20	80					0	0	1	0	0
IGHV1-69	28461	broad.mit.edu	37	14	107170193	107170193	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:107170193A>G	ENST00000390633.2	-	0	149																											AGGCTTCTTCACCTCAGCCCC	0.577000													14	215					0	0	1	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37126525	37126525	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:37126525A>G	ENST00000336755.5	+	2	302	c.196A>G	c.(196-198)Agt>Ggt	p.S66G	ZCCHC7_ENST00000461038.1_3'UTR|ZCCHC7_ENST00000322831.6_Missense_Mutation_p.S65G|ZCCHC7_ENST00000534928.1_Intron	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	66							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		GGAATCTTCGAGTAGTAAACC	0.418000													7	239					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847619	95847619	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:95847619A>G	ENST00000398107.2	+	4	1442	c.920A>G	c.(919-921)aAa>aGa	p.K307R	ZNF2_ENST00000295210.6_Missense_Mutation_p.K311R|ZNF2_ENST00000425369.1_Missense_Mutation_p.K269R|ZNF2_ENST00000340539.5_Missense_Mutation_p.K349R|ZNF2_ENST00000453539.2_Missense_Mutation_p.K362R	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		GAGTGTGGCAAAGCTTTCTTT	0.502000													4	145					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16515513	16515513	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16515513G>A	ENST00000602009.1	-	8	1747	c.852C>T	c.(850-852)ctC>ctT	p.L284L	EPS15L1_ENST00000594975.1_Silent_p.L438L|EPS15L1_ENST00000597937.1_Silent_p.L438L|EPS15L1_ENST00000535753.2_Silent_p.L438L|EPS15L1_ENST00000455140.2_Silent_p.L438L|EPS15L1_ENST00000248070.6_Silent_p.L438L			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	438	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						TCTGAGCCTCGAGCTCCTGCA	0.547000													21	54					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17804848	17804848	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:17804848G>A	ENST00000325083.8	+	7	1376	c.937G>A	c.(937-939)Gct>Act	p.A313T	PCM1_ENST00000518537.1_Missense_Mutation_p.A352T|PCM1_ENST00000519253.1_Missense_Mutation_p.A313T|PCM1_ENST00000524226.1_Missense_Mutation_p.A313T	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	313					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AGCAGAGCAAGCTATTGCAGT	0.403000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								53	150					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228462511	228462511	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:228462511C>T	ENST00000570156.2	+	24	7121	c.7047C>T	c.(7045-7047)ggC>ggT	p.G2349G	RP5-1139B12.3_ENST00000602529.1_RNA|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.G1974G|OBSCN_ENST00000359599.6_Silent_p.G821G|OBSCN_ENST00000422127.1_Silent_p.G1974G|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1334	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCTGAGGGCGCCTCATCCT	0.657000													5	17					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137593114	137593114	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:137593114C>A	ENST00000371817.3	+	4	1003	c.589C>A	c.(589-591)Ccc>Acc	p.P197T	COL5A1_ENST00000464187.1_3'UTR	NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	197	Laminin G-like.|TSP N-terminal.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CAGCGACCACCCCATGATCGA	0.542000													12	24					6.40141e-05	6.51258e-05	1	1	0
FOXF1	2294	broad.mit.edu	37	16	86544993	86544993	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:86544993C>T	ENST00000262426.4	+	1	861	c.818C>T	c.(817-819)tCg>tTg	p.S273L		NM_001451.2	NP_001442.2	Q12946	FOXF1_HUMAN	forkhead box F1	273					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(1)	12						TGGCCGCCCTCGGCGTCCGCG	0.746000													7	13					0	0	1	0	0
KCNMB4	27345	broad.mit.edu	37	12	70760631	70760631	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:70760631G>T	ENST00000258111.4	+	1	576	c.117G>T	c.(115-117)tgG>tgT	p.W39C		NM_014505.5	NP_055320.4	Q86W47	KCMB4_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 4	39					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding			kidney(1)|large_intestine(4)|lung(5)	10	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GCTTCTGCTGGCTGAGTCCCG	0.602000													9	78					1.12685e-05	1.15187e-05	1	1	0
MARK2	2011	broad.mit.edu	37	11	63662752	63662752	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:63662752T>C	ENST00000402010.2	+	2	755	c.176T>C	c.(175-177)aTt>aCt	p.I59T	MARK2_ENST00000513765.2_Missense_Mutation_p.I26T|MARK2_ENST00000508192.1_Missense_Mutation_p.I59T|MARK2_ENST00000350490.7_Missense_Mutation_p.I59T|MARK2_ENST00000413835.2_Missense_Mutation_p.I59T|MARK2_ENST00000315032.8_Missense_Mutation_p.I59T|MARK2_ENST00000361128.5_Missense_Mutation_p.I59T|MARK2_ENST00000377809.4_Missense_Mutation_p.I59T|MARK2_ENST00000509502.2_Missense_Mutation_p.I26T|MARK2_ENST00000425897.2_Missense_Mutation_p.I26T|MARK2_ENST00000377810.3_Missense_Mutation_p.I26T|MARK2_ENST00000408948.3_Missense_Mutation_p.I26T|MARK2_ENST00000502399.3_Missense_Mutation_p.I59T	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	59	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CTCAAGACCATTGGCAAGGGT	0.572000													26	83					0	0	1	0	0
CACYBP	27101	broad.mit.edu	37	1	174976282	174976282	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:174976282G>T	ENST00000367681.2	+	4	892	c.252G>T	c.(250-252)atG>atT	p.M84I	CACYBP_ENST00000405362.1_Missense_Mutation_p.M84I|CACYBP_ENST00000367679.2_Missense_Mutation_p.M127I	NM_001007214.1	NP_001007215.1	Q9HB71	CYBP_HUMAN	calcyclin binding protein	127	CS.|Interaction with SKP1.					beta-catenin destruction complex	protein homodimerization activity	p.M127I(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)	11						GTTACTCCATGATTGTGAACA	0.353000													23	71					2.21704e-12	2.30811e-12	1	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49377372	49377372	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49377372C>A	ENST00000200453.5	+	2	1151	c.882C>A	c.(880-882)gcC>gcA	p.A294A		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	294	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CAGCCCCAGCCCAGAGGCCCC	0.587000													34	68					1.836e-18	1.93239e-18	1	1	0
ATP6V0D1	9114	broad.mit.edu	37	16	67472484	67472484	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67472484A>G	ENST00000290949.3	-	8	1153	c.1003T>C	c.(1003-1005)Tgt>Cgt	p.C335R	ATP6V0D1_ENST00000602876.1_Missense_Mutation_p.C258R|ATP6V0D1_ENST00000567694.1_5'UTR|ATP6V0D1_ENST00000540149.1_Missense_Mutation_p.C376R	NM_004691.4	NP_004682.2	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	335					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex				large_intestine(3)|lung(3)|urinary_tract(2)	8		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		TGGGCGATACATTCAGCGATC	0.522000													30	65					0	0	1	0	0
FAN1	22909	broad.mit.edu	37	15	31210385	31210385	+	Silent	SNP	C	C	T	rs144494434	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:31210385C>T	ENST00000362065.4	+	6	2121	c.1830C>T	c.(1828-1830)caC>caT	p.H610H		NM_014967.4	NP_055782.3	Q9Y2M0	FAN1_HUMAN	FANCD2/FANCI-associated nuclease 1	610					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding			autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						CAGCCACGCACATGCTGAGTG	0.473000								Direct reversal of damage					4	106					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52185030	52185030	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52185030A>G	ENST00000394970.2	-	2	421		c.e2+1		POC1A_ENST00000296484.2_Splice_Site|POC1A_ENST00000474012.1_Splice_Site	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A							centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						GCCTCTTCTTACCCAGCTGCT	0.542000													49	145					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	172735823	172735823	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:172735823A>G	ENST00000506823.1	+	2	749	c.92A>G	c.(91-93)tAc>tGc	p.Y31C	GALNTL6_ENST00000511251.1_Missense_Mutation_p.Y31C	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	31						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.Y31C(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						TGGTCTCTGTACAAGGATAAG	0.493000													13	53					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50122668	50122668	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:50122668T>C	ENST00000376025.2	-	0	2878							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					ACCTCCAGCATAGCTGGTAAT	0.468000													23	35					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873756	189873756	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:189873756A>G	ENST00000304636.3	+	48	3802	c.3632A>G	c.(3631-3633)gAa>gGa	p.E1211G	COL3A1_ENST00000317840.5_Missense_Mutation_p.E908G	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1211					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ATTGGAGGTGAAAAAGCTGGC	0.532000													32	107					0	0	1	0	0
EFNA2	1943	broad.mit.edu	37	19	1299893	1299893	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1299893C>T	ENST00000215368.2	+	4	606	c.591C>T	c.(589-591)tgC>tgT	p.C197C	MUM1_ENST00000344663.3_Intron	NM_001405.3	NP_001396.2	O43921	EFNA2_HUMAN	ephrin-A2	197					cell-cell signaling	anchored to membrane|plasma membrane	ephrin receptor binding			lung(2)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGCGGCTGCCGCCTCTTCC	0.682000													4	14					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606662	55606662	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:55606662G>C	ENST00000378396.1	+	1	435	c.435G>C	c.(433-435)atG>atC	p.M145I		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TCTGTGCCATGCTGGTGGTTG	0.448000													31	76					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6439184	6439184	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6439184A>G	ENST00000162749.2	-	9	1116	c.817T>C	c.(817-819)Ttc>Ctc	p.F273L	TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.F230L	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	273					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						gtgggactgaagcttgggttt	0.602000													3	21					0	0	1	0	0
BMP8B	656	broad.mit.edu	37	1	40230438	40230438	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:40230438C>T	ENST00000372827.3	-	4	1100	c.725G>A	c.(724-726)cGc>cAc	p.R242H	BMP8B_ENST00000397360.2_Intron	NM_001720.3	NP_001711.2	P34820	BMP8B_HUMAN	bone morphogenetic protein 8b	242					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity			endometrium(1)|liver(1)|ovary(1)|urinary_tract(1)	4	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTGTTGGGAGCGTGGGGCCCG	0.657000													17	115					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169632741	169632741	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:169632741A>T	ENST00000335742.7	+	10	1842	c.485A>T	c.(484-486)gAa>gTa	p.E162V	PALLD_ENST00000505667.1_Missense_Mutation_p.E544V|PALLD_ENST00000512127.1_Missense_Mutation_p.E162V|PALLD_ENST00000261509.6_Missense_Mutation_p.E544V			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	544					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GCCAACACTGAAAACTGTAGT	0.448000									Pancreatic Cancer, Familial Clustering of				14	46					0	0	1	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057661	46057661	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:46057661T>C	ENST00000380095.1	+	1	389	c.327T>C	c.(325-327)tgT>tgC	p.C109C	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	109	15 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						tgcccgtctgtaacaagcctg	0.632000													59	195					0	0	1	0	0
SLC25A21	89874	broad.mit.edu	37	14	37153064	37153064	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:37153064G>A	ENST00000331299.5	-	9	1322	c.807C>T	c.(805-807)ggC>ggT	p.G269G	SLC25A21_ENST00000555449.1_Silent_p.G269G	NM_030631.3	NP_085134.1	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	269					lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|pancreas(1)|prostate(1)|skin(1)	9	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		TGGGAAGCAGGCCTTTGTACA	0.343000													6	28					0	0	1	0	0
GLCE	26035	broad.mit.edu	37	15	69548582	69548582	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:69548582A>G	ENST00000261858.2	+	3	665	c.437A>G	c.(436-438)tAt>tGt	p.Y146C	GLCE_ENST00000559420.2_Missense_Mutation_p.Y82C	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	146					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						GTGGTTCAGTATGATGGCTAT	0.423000													76	230					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878067	150878067	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150878067T>C	ENST00000422024.1	-	3	1323	c.1198A>G	c.(1198-1200)Aac>Gac	p.N400D	ASB10_ENST00000420175.2_Missense_Mutation_p.N355D|ASB10_ENST00000275838.1_Missense_Mutation_p.N355D|ASB10_ENST00000377867.3_Missense_Mutation_p.N340D|ASB10_ENST00000434669.1_Missense_Mutation_p.N400D	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	355					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGCCATGGTTGAGCAGAGCC	0.697000													7	25					0	0	1	0	0
PRDM13	59336	broad.mit.edu	37	6	100062519	100062519	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:100062519C>T	ENST00000369214.1	+	4	2299	c.2038C>T	c.(2038-2040)Ccc>Tcc	p.P680S	PRDM13_ENST00000369215.4_Missense_Mutation_p.P670S	NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	670					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		GGGTGCCGAGCCCGGCTATCC	0.697000													18	55					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110437463	110437463	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:110437463T>C	ENST00000378402.5	+	24	2949		c.e24+2			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCTTAAAGGTATATGAAAAA	0.313000										HNSCC(38;0.096)			4	36					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117655920	117655920	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:117655920T>C	ENST00000317775.6	-	28	4905	c.4220A>G	c.(4219-4221)tAc>tGc	p.Y1407C	NOS1_ENST00000338101.4_Missense_Mutation_p.Y1441C|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1407				Y -> I (in Ref. 3; AAA36376).	multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGTCACTTCGTACGTTCGCAG	0.483000													11	648					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169764399	169764399	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:169764399G>A	ENST00000375363.3	+	5	970	c.878G>A	c.(877-879)cGg>cAg	p.R293Q	SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000461586.1_3'UTR	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	293					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						CTGAGCTTCCGGTTGCTCTGT	0.483000													8	204					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143088755	143088755	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:143088755G>A	ENST00000275815.3	-	17	2896	c.2810C>T	c.(2809-2811)gCt>gTt	p.A937V		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	937	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GTCCAGCCCAGCCGAGTGGAA	0.622000													17	56					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897502	153897502	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:153897502C>T	ENST00000511601.1	+	12	3247	c.3059C>T	c.(3058-3060)cCg>cTg	p.P1020L	FHDC1_ENST00000260008.3_Missense_Mutation_p.P1020L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1020					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CCCAAGACCCCGTCAGTGCCC	0.607000													28	112					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124311303	124311303	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124311303G>A	ENST00000409039.3	+	24	3920	c.3895G>A	c.(3895-3897)Gaa>Aaa	p.E1299K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1299	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGAAGGAATTGAAGGTTTTCT	0.468000													31	189					0	0	1	0	0
BTBD2	55643	broad.mit.edu	37	19	1986864	1986864	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1986864G>A	ENST00000255608.4	-	8	1397	c.1381C>T	c.(1381-1383)Ccc>Tcc	p.P461S		NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	461						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGACGTTGGGCAGCACCTCC	0.662000													32	70					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89053770	89053770	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:89053770A>G	ENST00000286614.6	-	10	2024	c.1743T>C	c.(1741-1743)gtT>gtC	p.V581V		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	581					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						ACACAGTGTAAACCAATACAA	0.448000													35	131					0	0	1	0	0
RS1	6247	broad.mit.edu	37	X	18660262	18660262	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:18660262G>A	ENST00000379984.3	-	6	577	c.537C>T	c.(535-537)aaC>aaT	p.N179N	RS1_ENST00000476595.1_5'UTR|CDKL5_ENST00000379989.3_Intron|CDKL5_ENST00000379996.3_Intron	NM_000330.3	NP_000321.1	O15537	XLRS1_HUMAN	retinoschisin 1	179	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					TGCGGTCCGAGTTGCCATAGA	0.577000													7	63					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5087489	5087489	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:5087489G>A	ENST00000399604.4	-	1	203	c.63C>T	c.(61-63)tcC>tcT	p.S21S	ZNF594_ENST00000575779.1_Silent_p.S21S			Q96JF6	ZN594_HUMAN	zinc finger protein 594	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						GGAGTTTTTCGGATGCAGCCC	0.383000													25	57					0	0	1	0	0
TM9SF3	56889	broad.mit.edu	37	10	98282044	98282044	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98282044G>C	ENST00000371142.4	-	15	1962	c.1746C>G	c.(1744-1746)atC>atG	p.I582M		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	582						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		CATTAGTATAGATTTTTCGGA	0.358000													12	61					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10151636	10151636	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:10151636C>T	ENST00000428126.2	-	3	333	c.64_splice	c.e3+1	p.A22_splice	CLEC1B_ENST00000348658.4_Splice_Site_p.A22_splice|CLEC1B_ENST00000298527.6_Splice_Site_p.V22_splice			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	55					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						GCATTCTTACCGGAGATGAGA	0.333000													5	230					0	0	1	0	0
GPR176	11245	broad.mit.edu	37	15	40094085	40094085	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:40094085C>T	ENST00000299092.3	-	4	991	c.793G>A	c.(793-795)Gcc>Acc	p.A265T	GPR176_ENST00000543580.1_Missense_Mutation_p.A221T|GPR176_ENST00000561100.1_Missense_Mutation_p.A266T|GPR176_ENST00000560729.1_5'UTR	NM_001271854.1|NM_001271855.1	NP_001258783.1|NP_001258784.1	Q14439	GP176_HUMAN	G protein-coupled receptor 176	266					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)	23		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		AGCAGGGTGGCGTGCAGCTCG	0.582000											OREG0023053	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	110					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62546280	62546280	+	Missense_Mutation	SNP	C	C	T	rs111708484		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:62546280C>T	ENST00000541428.1	-	13	969	c.809G>A	c.(808-810)aGc>aAc	p.S270N	ASPH_ENST00000522919.1_Missense_Mutation_p.S112N|ASPH_ENST00000517847.2_Missense_Mutation_p.S285N|ASPH_ENST00000517903.1_Missense_Mutation_p.S284N|ASPH_ENST00000522835.1_Missense_Mutation_p.S242N|ASPH_ENST00000518068.1_Missense_Mutation_p.S256N|ASPH_ENST00000356457.5_Missense_Mutation_p.S299N|ASPH_ENST00000445642.3_Missense_Mutation_p.S285N|ASPH_ENST00000523897.1_5'UTR|ASPH_ENST00000379454.4_Missense_Mutation_p.S299N	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	299	Glu-rich.				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	AGGAAAAATGCTTACTTCTAA	0.289000													5	43					0	0	1	0	0
FAM71F2	346653	broad.mit.edu	37	7	128315777	128315777	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:128315777G>A	ENST00000480462.1	+	2	335	c.229G>A	c.(229-231)Gtg>Atg	p.V77M	FAM71F2_ENST00000477515.1_Missense_Mutation_p.V77M|FAM71F2_ENST00000378704.3_Missense_Mutation_p.V68M|FAM71F2_ENST00000460349.1_3'UTR			Q6NXP2	F71F2_HUMAN	family with sequence similarity 71, member F2	77										NS(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(2)	7						GTCTGCCACCGTGATCCTCGG	0.582000													18	39					0	0	1	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499756	59499756	+	Missense_Mutation	SNP	G	G	A	rs151212931	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:59499756G>A	ENST00000307144.4	+	1	715	c.617G>A	c.(616-618)cGt>cAt	p.R206H	MYO1E_ENST00000288235.4_Intron	NM_033195.2	NP_149972.1	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	206					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)	10					NADH(DB00157)	CCCAAAAACCGTATTATTGGA	0.423000													66	131					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59022657	59022657	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:59022657G>T	ENST00000263093.2	-	1	775	c.666C>A	c.(664-666)gcC>gcA	p.A222A	SLC27A5_ENST00000601355.1_Intron	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	222					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CCAGCACCCGGGCCCCAGAGC	0.672000													21	37					3.6726e-16	3.85282e-16	1	1	0
A2ML1	144568	broad.mit.edu	37	12	8975929	8975929	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:8975929A>G	ENST00000299698.7	+	2	394	c.214A>G	c.(214-216)Aag>Gag	p.K72E	A2ML1-AS1_ENST00000537288.1_RNA	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	0						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						CTCTGGACTGAAGAAGAGGCA	0.463000													19	89					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25130079	25130079	+	Missense_Mutation	SNP	C	C	T	rs149915066		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:25130079C>T	ENST00000332271.5	-	14	2095	c.1679G>A	c.(1678-1680)cGg>cAg	p.R560Q	PIWIL3_ENST00000533313.1_Missense_Mutation_p.R451Q|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.R451Q	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	560					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AGTATATTTCCGTAATGTGTC	0.328000													12	32					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101084391	101084391	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:101084391T>A	ENST00000360863.6	-	5	601	c.407A>T	c.(406-408)gAt>gTt	p.D136V	RGS22_ENST00000523437.1_Missense_Mutation_p.D136V|RGS22_ENST00000523287.1_Intron	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	136					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AAAGTAACAATCACTTTCCAG	0.338000													14	73					0	0	1	0	0
SLC43A2	124935	broad.mit.edu	37	17	1518310	1518310	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1518310G>A	ENST00000571650.1	-	4	693	c.387C>T	c.(385-387)tcC>tcT	p.S129S	SLC43A2_ENST00000301335.4_Silent_p.S129S|SLC43A2_ENST00000382147.4_Silent_p.S129S			Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2	129					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TCAGCAAGCAGGAAACCGCGA	0.468000													9	42					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773100	145773100	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145773100C>T	ENST00000276826.5	-	4	1571	c.1370G>A	c.(1369-1371)cGg>cAg	p.R457Q	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.R457Q|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.R457Q			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	457					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CTGGCTGTGCCGCAGCTCAGG	0.687000													7	22					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127647003	127647003	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:127647003C>T	ENST00000508053.1	-	45	6037	c.5063G>A	c.(5062-5064)cGc>cAc	p.R1688H	FBN2_ENST00000262464.4_Missense_Mutation_p.R1688H			P35556	FBN2_HUMAN	fibrillin 2	1688	EGF-like 27; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTCACAGATGCGGGTATCCTC	0.502000													8	44					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513014	61513014	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:61513014T>C	ENST00000266070.4	-	16	4619	c.4294A>G	c.(4294-4296)Acc>Gcc	p.T1432A	DIDO1_ENST00000395343.1_Missense_Mutation_p.T1432A	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1432					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCTAAGATGGTCTCATCCTCG	0.617000													8	269					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14756037	14756037	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:14756037C>T	ENST00000284268.6	-	4	779	c.449G>A	c.(448-450)gGc>gAc	p.G150D		NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	150					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TAAGAGAATGCCAGCATGGGT	0.438000													4	76					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123195575	123195575	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:123195575A>G	ENST00000264501.4	+	49	8897	c.8524A>G	c.(8524-8526)Att>Gtt	p.I2842V	KIAA1109_ENST00000455637.1_Missense_Mutation_p.I2842V|KIAA1109_ENST00000388738.3_Missense_Mutation_p.I2842V			Q2LD37	K1109_HUMAN	KIAA1109	2842					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GCTTGAAGGGATTACACCAAA	0.299000													14	62					0	0	1	0	0
IFNA2	3440	broad.mit.edu	37	9	21385105	21385105	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:21385105G>C	ENST00000380206.2	-	1	291	c.224C>G	c.(223-225)aCc>aGc	p.T75S		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	75					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GACAGGGATGGTTTCAGCCTT	0.478000													6	211					0	0	1	0	0
CLUAP1	23059	broad.mit.edu	37	16	3554830	3554830	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3554830A>G	ENST00000571025.1	+	2	183	c.134_splice	c.e2+1	p.R45_splice	LA16c-306E5.3_ENST00000574423.2_RNA|CLUAP1_ENST00000417763.2_5'UTR|CLUAP1_ENST00000341633.5_Splice_Site_p.R45_splice|CLUAP1_ENST00000576634.1_Splice_Site_p.R45_splice			Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1	45						nucleus	protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(2)	16						GCTTGTGAAAAGGTTCGAACG	0.408000													10	43					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17589746	17589746	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:17589746G>A	ENST00000319363.6	+	13	1770	c.1637G>A	c.(1636-1638)cGc>cAc	p.R546H		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	546					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CAGCCGGGCCGCATGCACCGC	0.706000													4	10					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4398027	4398027	+	Nonsense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:4398027C>G	ENST00000261254.3	+	4	860	c.591C>G	c.(589-591)taC>taG	p.Y197*		NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	197					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TTGCCATGTACCCACCGTCGA	0.542000			T	IGL@	"""NHL,CLL"""								49	201					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36316458	36316458	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:36316458A>G	ENST00000373210.3	+	17	2526	c.2281A>G	c.(2281-2283)Acc>Gcc	p.T761A	AGO4_ENST00000488778.1_3'UTR	NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		TCCTCAGGGAACCAGCCGTCC	0.403000													29	72					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75227813	75227813	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:75227813T>C	ENST00000342232.4	-	2	462	c.422A>G	c.(421-423)tAc>tGc	p.Y141C		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	141	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GCGCACGCCGTAGCCATGCCG	0.682000													12	52					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20482639	20482639	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20482639G>T	ENST00000305045.2	-	1	713	c.714C>A	c.(712-714)ctC>ctA	p.L238L		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AGCAAGTGGAGAGTGCTTTGG	0.512000													13	49					5.50884e-06	5.63245e-06	1	1	0
PLK1	5347	broad.mit.edu	37	16	23701352	23701352	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:23701352C>T	ENST00000300093.4	+	10	1891	c.1780C>T	c.(1780-1782)Cgc>Tgc	p.R594C		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	594					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		GCTGAGCTCACGCTCGGCCAG	0.647000													22	59					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139950	50139950	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:50139950G>A	ENST00000371564.3	-	2	1049	c.830C>T	c.(829-831)cCg>cTg	p.P277L	NFATC2_ENST00000396009.3_Missense_Mutation_p.P277L|NFATC2_ENST00000414705.1_Missense_Mutation_p.P257L	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	277	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					TGAGGGCTGCGGCGAGGGGCT	0.711000													7	27					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92568216	92568216	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:92568216C>T	ENST00000370382.3	+	3	801	c.534C>T	c.(532-534)ttC>ttT	p.F178F	BTBD8_ENST00000540648.1_Silent_p.F178F|BTBD8_ENST00000342818.3_Silent_p.F178F			Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	178						nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		ATGATGATTTCATTTCCAATG	0.323000													12	49					0	0	1	0	0
HSPA9	3313	broad.mit.edu	37	5	137902705	137902705	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:137902705C>A	ENST00000297185.3	-	8	989	c.864G>T	c.(862-864)aaG>aaT	p.K288N		NM_004134.6	NP_004125.3	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 (mortalin)	288					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCTTGAACTCCTTCACAATGT	0.413000													47	168					1.83081e-24	1.93732e-24	1	1	0
RAB11FIP3	9727	broad.mit.edu	37	16	570491	570491	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:570491G>A	ENST00000262305.4	+	13	2437	c.2049G>A	c.(2047-2049)gaG>gaA	p.E683E	RAB11FIP3_ENST00000457159.1_Silent_p.E728E|RAB11FIP3_ENST00000450428.1_Silent_p.E387E	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	683					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				AGAACGAGGAGCTGAACGGGC	0.602000													5	115					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89087643	89087643	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:89087643G>A	ENST00000554922.1	-	38	5264	c.5016C>T	c.(5014-5016)ggC>ggT	p.G1672G	EML5_ENST00000553320.1_5'UTR|EML5_ENST00000380664.5_Silent_p.G1664G|EML5_ENST00000352093.5_Silent_p.G1626G	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1664						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAAGGATCTTGCCCTGAAACA	0.388000													49	140					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271695	36271695	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:36271695A>G	ENST00000007510.4	+	10	950	c.806A>G	c.(805-807)cAg>cGg	p.Q269R	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.Q133R|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.Q269R			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	269					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CCGGCTCCCCAGGGTATCTCG	0.627000													31	115					0	0	1	0	0
DET1	55070	broad.mit.edu	37	15	89073994	89073994	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:89073994C>T	ENST00000564406.1	-	3	1136	c.976G>A	c.(976-978)Gcc>Acc	p.A326T	DET1_ENST00000268148.8_Missense_Mutation_p.A315T|DET1_ENST00000444300.1_Missense_Mutation_p.A326T	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	315						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			CGCCTCTTGGCCATTGCACTA	0.493000													6	27					0	0	1	0	0
ELMO2	63916	broad.mit.edu	37	20	45022217	45022217	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:45022217T>C	ENST00000290246.6	-	5	337	c.143A>G	c.(142-144)tAt>tGt	p.Y48C	ELMO2_ENST00000372176.1_5'UTR|ELMO2_ENST00000488853.1_5'UTR|ELMO2_ENST00000352077.2_Missense_Mutation_p.Y48C|ELMO2_ENST00000396391.1_Missense_Mutation_p.Y48C|ELMO2_ENST00000445496.2_5'UTR|ELMO2_ENST00000439931.2_Missense_Mutation_p.Y48C	NM_133171.3	NP_573403.1	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	48					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				GAGGGTATAATACTCTGGGTT	0.438000													86	237					0	0	1	0	0
GALNT18	374378	broad.mit.edu	37	11	11398738	11398738	+	Missense_Mutation	SNP	G	G	A	rs146816102	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:11398738G>A	ENST00000227756.4	-	5	1379	c.968C>T	c.(967-969)gCg>gTg	p.A323V		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		CCTGATTGGCGCTGTGGAGTT	0.567000													25	61					0	0	1	0	0
PDXK	8566	broad.mit.edu	37	21	45168916	45168916	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45168916T>C	ENST00000291565.4	+	6	602	c.419T>C	c.(418-420)gTg>gCg	p.V140A	PDXK_ENST00000468090.1_Missense_Mutation_p.V112A|PDXK_ENST00000467908.1_Missense_Mutation_p.V100A	NM_003681.4	NP_003672.1	O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	140					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	AAAGAAAAAGTGGTGCCGCTT	0.483000													9	99					0	0	1	0	0
DIS3L2	129563	broad.mit.edu	37	2	233001426	233001426	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233001426T>C	ENST00000325385.7	+	8	1223	c.947T>C	c.(946-948)cTg>cCg	p.L316P	DIS3L2_ENST00000273009.6_Missense_Mutation_p.L316P|DIS3L2_ENST00000409307.1_Missense_Mutation_p.L316P|DIS3L2_ENST00000360410.4_Missense_Mutation_p.W336R	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	316							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AATTTTGCCCTGGGGTAGGTG	0.448000													25	87					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19576215	19576215	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:19576215C>T	ENST00000438132.3	+	2	375	c.327C>T	c.(325-327)tgC>tgT	p.C109C	C16orf62_ENST00000417362.2_Silent_p.C20C|C16orf62_ENST00000538853.1_Silent_p.C109C|C16orf62_ENST00000251143.5_Silent_p.C20C|C16orf62_ENST00000542263.1_Silent_p.C109C	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	20						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						TTGCATCATGCCGACTGGAGG	0.428000													17	48					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72163772	72163772	+	Missense_Mutation	SNP	C	C	T	rs148707586		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:72163772C>T	ENST00000357731.4	-	4	825	c.586G>A	c.(586-588)Gac>Aac	p.D196N	NEGR1_ENST00000306821.3_Missense_Mutation_p.D68N|NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Intron	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	196	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		CCAGCCTGGTCCCTTGTAATT	0.378000													7	37					0	0	1	0	0
CEP57	9702	broad.mit.edu	37	11	95546694	95546694	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:95546694T>C	ENST00000325542.5	+	4	683	c.445T>C	c.(445-447)Tac>Cac	p.Y149H	CEP57_ENST00000541150.1_Missense_Mutation_p.Y140H|CEP57_ENST00000537677.1_Missense_Mutation_p.Y122H|CEP57_ENST00000325486.5_Missense_Mutation_p.Y149H|CEP57_ENST00000536587.1_3'UTR|CEP57_ENST00000538658.1_Missense_Mutation_p.Y149H	NM_001243776.1|NM_014679.4	NP_001230705.1|NP_055494.2	Q86XR8	CEP57_HUMAN	centrosomal protein 57kDa	149	centrosome localization domain (CLD) (By similarity).				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ACAATTGGAATACATGCGAAA	0.338000									Mosaic Variegated Aneuploidy Syndrome				10	41					0	0	1	0	0
TXNDC9	10190	broad.mit.edu	37	2	99949571	99949571	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99949571T>C	ENST00000264255.3	-	2	358	c.103A>G	c.(103-105)Aaa>Gaa	p.K35E	TXNDC9_ENST00000409434.1_Missense_Mutation_p.K35E	NM_005783.3	NP_005774.2	O14530	TXND9_HUMAN	thioredoxin domain containing 9	35					cell redox homeostasis		protein binding			lung(1)	1						TGATCCAGTTTTTGAATTTCA	0.438000													9	88					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14781658	14781658	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:14781658A>G	ENST00000261170.3	-	20	2307	c.2171T>C	c.(2170-2172)gTa>gCa	p.V724A		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	724	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ACAGTTTTTTACAAGTAGGTA	0.348000													25	77					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79054654	79054654	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:79054654A>G	ENST00000446378.2	+	7	11220	c.11189A>G	c.(11188-11190)aAc>aGc	p.N3730S	CMYA5_ENST00000505466.1_3'UTR	NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3730	Fibronectin type-III 1.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGGAGCATGAACAAGGAAGAT	0.393000													26	77					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40080370	40080370	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:40080370T>C	ENST00000336649.4	+	39	5912	c.5912T>C	c.(5911-5913)tTc>tCc	p.F1971S	CACNA1I_ENST00000402142.3_Missense_Mutation_p.F1965S|CACNA1I_ENST00000401624.1_Missense_Mutation_p.F1965S|CACNA1I_ENST00000400164.3_Missense_Mutation_p.F1930S|CACNA1I_ENST00000404898.1_Missense_Mutation_p.F1930S|CACNA1I_ENST00000407673.1_Missense_Mutation_p.F1930S			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1965					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCCGAGTTCTTCCACCCTGCA	0.637000													9	31					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5172715	5172715	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5172715A>G	ENST00000380367.1	-	2	1302	c.885T>C	c.(883-885)taT>taC	p.Y295Y	OR52A1_ENST00000328942.1_Silent_p.Y295Y			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	295					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTTTGCACCATAGACAAGTG	0.383000													44	138					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42221417	42221417	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42221417C>T	ENST00000221992.6	+	5	1116	c.1002C>T	c.(1000-1002)ccC>ccT	p.P334P	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Silent_p.P333P|CEACAM5_ENST00000405816.1_Silent_p.P334P	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	334	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane		p.P334P(1)		breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		ACTCCAACCCCGTGGAGGATG	0.532000													48	141					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70349193	70349193	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:70349193C>T	ENST00000333646.6	+	26	3804	c.3605C>T	c.(3604-3606)tCc>tTc	p.S1202F	MED12_ENST00000374080.3_Missense_Mutation_p.S1202F|MED12_ENST00000374102.1_Missense_Mutation_p.S1202F	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1202					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					ATCCGCTCCTCCTGCGACCGC	0.567000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome				OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	20					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761081	92761081	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:92761081G>A	ENST00000318238.4	-	5	5420	c.4204C>T	c.(4204-4206)Cca>Tca	p.P1402S	SAMD9L_ENST00000411955.1_Missense_Mutation_p.P1402S|SAMD9L_ENST00000437805.1_Missense_Mutation_p.P1402S	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1402										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GTGGTAAGTGGTTGAATTAAC	0.403000													44	185					0	0	1	0	0
PLA2G5	5322	broad.mit.edu	37	1	20416375	20416375	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:20416375C>T	ENST00000375108.3	+	4	547	c.279C>T	c.(277-279)ggC>ggT	p.G93G	PLA2G5_ENST00000486277.1_3'UTR	NM_000929.2	NP_000920.1	P39877	PA2G5_HUMAN	phospholipase A2, group V	93					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity	p.G93G(2)		NS(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		TCGCGTGGGGCGTGGTCACCT	0.582000													16	30					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52962046	52962046	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52962046A>G	ENST00000549343.1	-	8	1342	c.1304T>C	c.(1303-1305)aTg>aCg	p.M435T	KRT74_ENST00000305620.2_Missense_Mutation_p.M421T			Q7RTS7	K2C74_HUMAN	keratin 74	421	Coil 2.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		CTCGCGCAGCATCCGCGCCAG	0.647000													31	139					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124285853	124285853	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124285853T>C	ENST00000409039.3	+	15	2159	c.2134T>C	c.(2134-2136)Ttg>Ctg	p.L712L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	712	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACAGCGCATGTTGGATCATTA	0.463000													58	255					0	0	1	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313290	1313290	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:1313290G>A	ENST00000296839.2	+	1	616	c.351G>A	c.(349-351)cgG>cgA	p.R117R		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	117					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ATACGCGGCGGCCCAAGCCCC	0.746000													17	34					0	0	1	0	0
AGBL2	79841	broad.mit.edu	37	11	47732033	47732033	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47732033G>A	ENST00000525123.1	-	4	413	c.128C>T	c.(127-129)aCg>aTg	p.T43M	AGBL2_ENST00000357610.3_Missense_Mutation_p.T43M|AGBL2_ENST00000298861.4_Missense_Mutation_p.T43M|AGBL2_ENST00000529712.1_5'UTR|AGBL2_ENST00000528244.1_Missense_Mutation_p.T43M	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	43					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						ATGCTGATGCGTAGCAGAGTT	0.433000													25	80					0	0	1	0	0
KLHL42	57542	broad.mit.edu	37	12	27950995	27950995	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27950995T>C	ENST00000381271.2	+	3	1725	c.1414T>C	c.(1414-1416)Tac>Cac	p.Y472H		NM_020782.1	NP_065833.1			kelch-like family member 42																		GTTCCTCAAGTACAACATCTT	0.463000													24	80					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26220330	26220330	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:26220330G>A	ENST00000380737.3	+	7	1097	c.768G>A	c.(766-768)atG>atA	p.M256I	PPP2R2A_ENST00000315985.7_Missense_Mutation_p.M266I	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha									p.M256I(2)		kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TATGTGACATGAGGGCATCTG	0.373000													8	44					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7586071	7586071	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:7586071C>G	ENST00000379802.3	+	24	8917	c.8576C>G	c.(8575-8577)tCt>tGt	p.S2859C	DSP_ENST00000418664.2_Missense_Mutation_p.S2260C	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2859	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCTTCCTACTCTTATTCCTAC	0.507000													41	128					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50599150	50599150	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:50599150C>T	ENST00000262794.5	+	25	3441	c.3358C>T	c.(3358-3360)Cga>Tga	p.R1120*	MOV10L1_ENST00000545383.1_Nonsense_Mutation_p.R1120*|MOV10L1_ENST00000540615.1_Nonsense_Mutation_p.R1100*|MOV10L1_ENST00000395852.1_Nonsense_Mutation_p.R247*|MOV10L1_ENST00000395858.3_Intron	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	1120					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGAAGATGATCGATATTTTTT	0.393000													19	54					0	0	1	0	0
GTF2F2	2963	broad.mit.edu	37	13	45710869	45710869	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:45710869T>C	ENST00000340473.6	+	2	209	c.66_splice	c.e2-1	p.V23_splice		NM_004128.2	NP_004119.1	P13984	T2FB_HUMAN	general transcription factor IIF, polypeptide 2, 30kDa	23					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	microtubule cytoskeleton|transcription factor TFIIF complex	ATP binding|ATP-dependent helicase activity|DNA binding|protein binding			breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|prostate(1)|upper_aerodigestive_tract(1)	10		Lung NSC(96;0.00115)|Prostate(109;0.00578)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000647)		TTGTTTTAGGTTCCTAAATAT	0.313000													9	39					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12905677	12905677	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:12905677C>T	ENST00000338034.4	-	14	1458		c.e14-1		ELAC2_ENST00000395962.2_Splice_Site|ELAC2_ENST00000426905.3_Splice_Site	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2						tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						GGCCCTCCTTCTGAAAGAGAC	0.572000													17	44					0	0	1	0	0
APPBP2	10513	broad.mit.edu	37	17	58571911	58571911	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:58571911A>G	ENST00000083182.3	-	3	582	c.295T>C	c.(295-297)Tac>Cac	p.Y99H		NM_006380.2	NP_006371.2	Q92624	APBP2_HUMAN	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	99					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(17)|pancreas(1)|urinary_tract(1)	25	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			CTGAATGAGTAGGCCAAGACT	0.373000													12	99					0	0	1	0	0
MIR602	693187	broad.mit.edu	37	9	140732933	140732933	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140732933G>A	ENST00000384960.1	+	0	63					NR_030333.1																						GGCCGAGTGCGTCTCCTGTCA	0.622000													4	163					0	0	1	0	0
LIG3	3980	broad.mit.edu	37	17	33321416	33321416	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:33321416T>C	ENST00000378526.4	+	9	1710	c.1577T>C	c.(1576-1578)tTc>tCc	p.F526S	LIG3_ENST00000262327.5_Missense_Mutation_p.F526S	NM_013975.3	NP_039269.2	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent	526					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			endometrium(4)|large_intestine(8)|lung(9)|ovary(3)|pancreas(2)|prostate(1)|skin(3)|stomach(1)	31		Ovarian(249;0.17)			Bleomycin(DB00290)	TTCAGCTACTTCAGCCGCAGT	0.512000								Other BER factors					6	130					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145001841	145001841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145001841G>A	ENST00000322810.4	-	27	4073	c.3904C>T	c.(3904-3906)Cag>Tag	p.Q1302*	PLEC_ENST00000527096.1_Nonsense_Mutation_p.Q1188*|PLEC_ENST00000356346.3_Nonsense_Mutation_p.Q1151*|PLEC_ENST00000436759.2_Nonsense_Mutation_p.Q1192*|PLEC_ENST00000357649.2_Nonsense_Mutation_p.Q1169*|PLEC_ENST00000354589.3_Nonsense_Mutation_p.Q1165*|PLEC_ENST00000398774.2_Nonsense_Mutation_p.Q1133*|PLEC_ENST00000345136.3_Nonsense_Mutation_p.Q1165*|PLEC_ENST00000354958.2_Nonsense_Mutation_p.Q1143*	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1302	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCGTGCCGCTGCTGCAGTCGC	0.731000													6	14					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3119235	3119235	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:3119235G>A	ENST00000078429.4	+	6	1009	c.767G>A	c.(766-768)cGg>cAg	p.R256Q	AC005262.3_ENST00000587701.1_RNA|GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	256					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		GCCCTGTTCCGGACCATCATC	0.607000			Mis		uveal melanoma								58	151					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33014698	33014698	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:33014698A>G	ENST00000280979.4	+	4	1009	c.839A>G	c.(838-840)gAc>gGc	p.D280G	AKAP6_ENST00000557272.1_Missense_Mutation_p.D280G|AKAP6_ENST00000557354.1_Missense_Mutation_p.D280G	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	280					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTAGCTGCTGACTCTATCTCT	0.448000													47	145					0	0	1	0	0
EMP1	2012	broad.mit.edu	37	12	13364476	13364476	+	Missense_Mutation	SNP	T	T	C	rs147282605	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:13364476T>C	ENST00000256951.5	+	2	231	c.32T>C	c.(31-33)gTc>gCc	p.V11A	EMP1_ENST00000542289.1_Splice_Site|EMP1_ENST00000537612.1_Missense_Mutation_p.V11A|EMP1_ENST00000396301.3_Missense_Mutation_p.V11A|EMP1_ENST00000544053.1_Intron|EMP1_ENST00000431267.2_Intron	NM_001423.2	NP_001414.1	P54849	EMP1_HUMAN	epithelial membrane protein 1	11					cell growth|cell proliferation|epidermis development	integral to membrane|membrane fraction							Prostate(47;0.194)		BRCA - Breast invasive adenocarcinoma(232;0.153)		ATCTTTGTGGTCCACATCGCT	0.348000													4	206					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31500266	31500266	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:31500266G>A	ENST00000330498.3	+	11	1365	c.1346G>A	c.(1345-1347)gGc>gAc	p.G449D		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	449					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GCGGCACAGGGCGGGCAGCTC	0.662000													7	81					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49444587	49444587	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:49444587G>A	ENST00000374201.3	-	9	1233	c.931C>T	c.(931-933)Cca>Tca	p.P311S	FRMPD2_ENST00000407470.4_Missense_Mutation_p.P280S|FRMPD2_ENST00000305531.3_Missense_Mutation_p.P287S	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	311					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		ATGAACTCTGGCCTGGAAAAC	0.562000													23	63					0	0	1	0	0
CLIC1	1192	broad.mit.edu	37	6	31700051	31700051	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31700051A>G	ENST00000375780.2	-	6	1079	c.507T>C	c.(505-507)gaT>gaC	p.D169D	CLIC1_ENST00000375784.3_Silent_p.D169D|CLIC1_ENST00000395892.1_Silent_p.D169D|CLIC1_ENST00000375779.2_Silent_p.D169D			O00299	CLIC1_HUMAN	chloride intracellular channel 1	169	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity	p.D169E(1)		central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)|skin(1)	7						GCTCGTTGCCATCCAAAAACT	0.498000													31	77					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117150895	117150895	+	Silent	SNP	C	C	T	rs61730485		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:117150895C>T	ENST00000369486.3	-	5	1656	c.891G>A	c.(889-891)ccG>ccA	p.P297P	IGSF3_ENST00000318837.6_Silent_p.P297P|IGSF3_ENST00000369483.1_Silent_p.P297P	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	297	Ig-like C2-type 3.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TGAACTCCACCGGCTCGCCCA	0.542000													7	26					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:70993145A>G	ENST00000396396.1	+	2	521	c.292A>G	c.(292-294)Atc>Gtc	p.I98V	PGM5_ENST00000396392.1_Missense_Mutation_p.I98V|PGM5_ENST00000604870.2_3'UTR	NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity	p.I98V(3)		endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						ACAGAATGGCATCTTGTCGAC	0.478000													12	99					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692879	135692879	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:135692879G>A	ENST00000513104.1	-	2	479	c.197C>T	c.(196-198)tCc>tTc	p.S66F	TRPC7_ENST00000355180.3_Missense_Mutation_p.S66F|TRPC7_ENST00000426057.2_Missense_Mutation_p.S66F	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	66					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AAGGGTCTTGGACTCCTCCAG	0.592000													5	205					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1841424	1841424	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:1841424C>T	ENST00000415638.3	-	2	1188	c.1109G>A	c.(1108-1110)cGc>cAc	p.R370H	IGFALS_ENST00000215539.3_Missense_Mutation_p.R332H	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	332					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						CTCAAAGCTGCGCTCAGCCAG	0.667000													9	25					0	0	1	0	0
CLASRP	11129	broad.mit.edu	37	19	45567447	45567447	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45567447G>A	ENST00000544944.2	+	11	1775	c.1083G>A	c.(1081-1083)caG>caA	p.Q361Q	CLASRP_ENST00000391953.4_Silent_p.Q299Q|CLASRP_ENST00000221455.3_Silent_p.Q361Q			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	361					mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						CACCTCCCCAGCCTGGCGGCC	0.721000													7	29					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4715983	4715983	+	Silent	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:4715983A>C	ENST00000302640.8	+	21	2859	c.2509A>C	c.(2509-2511)Agg>Cgg	p.R837R	ITPR1_ENST00000456211.2_Silent_p.R837R|ITPR1_ENST00000423119.2_Silent_p.R852R|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000443694.2_Silent_p.R837R|ITPR1_ENST00000354582.6_Silent_p.R852R|ITPR1_ENST00000357086.4_Silent_p.R852R	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	852					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGTTTGTCAGAGGTTCCCTTT	0.388000													4	7					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169845472	169845472	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:169845472A>G	ENST00000335742.7	+	19	3957	c.2600A>G	c.(2599-2601)tAc>tGc	p.Y867C	CBR4_ENST00000509108.1_Intron|PALLD_ENST00000505667.1_Missense_Mutation_p.Y1042C|PALLD_ENST00000507735.1_Missense_Mutation_p.Y538C|PALLD_ENST00000512127.1_Missense_Mutation_p.Y643C|PALLD_ENST00000261509.6_Missense_Mutation_p.Y1025C			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1249	Interaction with ACTN.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GCTGATGGGTACCCAGTGCGG	0.448000									Pancreatic Cancer, Familial Clustering of				22	45					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7726882	7726882	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7726882G>A	ENST00000572933.1	+	74	12725	c.11265G>A	c.(11263-11265)gaG>gaA	p.E3755E	DNAH2_ENST00000389173.2_Silent_p.E3755E			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3755					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTCCTTTGAGCAGTACCCTC	0.532000													4	99					0	0	1	0	0
C9orf41	138199	broad.mit.edu	37	9	77599851	77599851	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:77599851A>G	ENST00000376834.3	-	7	1252	c.1100T>C	c.(1099-1101)gTt>gCt	p.V367A	RP11-197P3.4_ENST00000455609.1_RNA|C9orf41_ENST00000376837.3_3'UTR	NM_152420.1	NP_689633.1	Q8N4J0	CI041_HUMAN	chromosome 9 open reading frame 41	367										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|urinary_tract(2)	17						CTGCAGAACAACGTTTTTTAT	0.358000													9	61					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19967712	19967712	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:19967712G>A	ENST00000263207.3	-	6	1241	c.950C>T	c.(949-951)gCg>gTg	p.A317V	ARVCF_ENST00000401994.1_Missense_Mutation_p.A254V|ARVCF_ENST00000344269.3_Missense_Mutation_p.A254V|ARVCF_ENST00000406522.1_Missense_Mutation_p.A254V|ARVCF_ENST00000406259.1_Missense_Mutation_p.A317V	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	317					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CATTGGGAACGCAGGCCGCTC	0.711000													17	44					0	0	1	0	0
DCBLD2	131566	broad.mit.edu	37	3	98538090	98538090	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:98538090T>A	ENST00000326840.6	-	8	1405	c.1043A>T	c.(1042-1044)tAc>tTc	p.Y348F	DCBLD2_ENST00000326857.9_Missense_Mutation_p.Y348F	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	348	F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						TAACCACTGGTATTCATCAGT	0.378000													4	10					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205312508	205312508	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:205312508G>A	ENST00000367156.3	-	5	1041	c.225C>T	c.(223-225)acC>acT	p.T75T	KLHDC8A_ENST00000460687.1_Intron|KLHDC8A_ENST00000537168.1_Intron|KLHDC8A_ENST00000367155.3_Silent_p.T75T|KLHDC8A_ENST00000539253.1_Silent_p.T75T	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	75										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TCCCCAGGGCGGTGACGGCCA	0.667000													56	173					0	0	1	0	0
PRPH	5630	broad.mit.edu	37	12	49689166	49689166	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49689166T>C	ENST00000257860.4	+	1	1682	c.183T>C	c.(181-183)cgT>cgC	p.R61R	RP11-161H23.9_ENST00000553259.1_RNA	NM_006262.3	NP_006253.2	P41219	PERI_HUMAN	peripherin	61	Head.						structural molecule activity	p.R61R(1)		kidney(1)|large_intestine(2)|lung(8)|skin(1)	12						GCAGCTTCCGTAGCCCCCGAG	0.736000													7	27					0	0	1	0	0
TRAV12-3	28672	broad.mit.edu	37	14	22434142	22434142	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:22434142C>T	ENST00000390442.3	+	0	251																											CCAGAAAAGGCCCTGAGTTGC	0.433000													8	244					0	0	1	0	0
NLN	57486	broad.mit.edu	37	5	65105442	65105442	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:65105442G>A	ENST00000380985.5	+	10	1806	c.1628G>A	c.(1627-1629)cGa>cAa	p.R543Q	NLN_ENST00000502464.1_Missense_Mutation_p.R439Q	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	543					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		GATTCCCTCCGAAGATTGTCA	0.423000													19	71					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139096923	139096923	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:139096923T>C	ENST00000333188.5	-	5	645	c.464A>G	c.(463-465)aAc>aGc	p.N155S	COPB2_ENST00000507777.1_Missense_Mutation_p.N126S	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	155					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						AAACTGATTGTTATCTTTGGG	0.408000													51	149					0	0	1	0	0
SLC39A4	55630	broad.mit.edu	37	8	145638731	145638731	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145638731A>G	ENST00000276833.5	-	9	1745	c.1442T>C	c.(1441-1443)gTg>gCg	p.V481A	SLC39A4_ENST00000531013.1_5'UTR|SLC39A4_ENST00000301305.3_Missense_Mutation_p.V506A	NM_017767.2	NP_060237.2	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter), member 4	506						cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	14	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			GAAGTTGTGCACGGCGTCGCC	0.687000													7	34					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23313942	23313942	+	Silent	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23313942T>G	ENST00000311852.6	+	8	1515	c.1254T>G	c.(1252-1254)gcT>gcG	p.A418A	MMP14_ENST00000548162.1_3'UTR	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	418	Hemopexin-like 3.					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TTGATGCTGCTCTCTTCTGGA	0.552000													13	141					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208489	50208489	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50208489C>T	ENST00000392518.4	+	10	1270	c.898C>T	c.(898-900)Cgc>Tgc	p.R300C	CPT1C_ENST00000323446.5_Missense_Mutation_p.R300C|CPT1C_ENST00000405931.2_Missense_Mutation_p.R289C|CPT1C_ENST00000354199.5_Missense_Mutation_p.R300C|CPT1C_ENST00000598293.1_Missense_Mutation_p.R300C	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	300					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GATGGGAATGCGCCCCTTATG	0.587000													52	151					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183944273	183944273	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:183944273T>C	ENST00000361927.4	-	3	821	c.450A>G	c.(448-450)gcA>gcG	p.A150A	COLGALT2_ENST00000546159.1_Silent_p.A150A	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		TTCGAAGGGCTGCCTGTCGTA	0.428000													6	82					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81978944	81978944	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:81978944C>T	ENST00000356860.3	-	2	455	c.117G>A	c.(115-117)aaG>aaA	p.K39K	CACNA2D1_ENST00000423588.1_Silent_p.K39K|CACNA2D1_ENST00000356253.5_Silent_p.K39K	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	39						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTTCTTGCATCTTATCCACCC	0.363000													15	85					0	0	1	0	0
IL23R	149233	broad.mit.edu	37	1	67724679	67724679	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:67724679A>G	ENST00000347310.5	+	11	1929	c.1758A>G	c.(1756-1758)gaA>gaG	p.E586E	IL23R_ENST00000473881.1_3'UTR|IL23R_ENST00000371002.1_3'UTR|IL23R_ENST00000395227.1_Silent_p.E331E	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	586					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						CTATTCCAGAACAGACCCTGC	0.398000													21	110					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79581222	79581222	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:79581222G>A	ENST00000372391.2	-	15	3025	c.3020C>T	c.(3019-3021)gCg>gTg	p.A1007V	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1007	Pro-rich.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CAGAGGCCCCGCCCTCTTGGA	0.592000													42	102					0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	132891465	132891465	+	Missense_Mutation	SNP	C	C	T	rs139123582	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:132891465C>T	ENST00000368642.4	-	12	1806	c.1721G>A	c.(1720-1722)cGg>cAg	p.R574Q		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	574										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		TTCCTTGTCCCGTTTCTTAAG	0.478000													13	53					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32260981	32260981	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32260981T>G	ENST00000375015.4	-	26	1666	c.1466A>C	c.(1465-1467)aAg>aCg	p.K489T	C6orf10_ENST00000527965.1_Missense_Mutation_p.K474T|C6orf10_ENST00000447241.2_Missense_Mutation_p.K490T|C6orf10_ENST00000375007.4_Missense_Mutation_p.K488T|C6orf10_ENST00000533191.1_Missense_Mutation_p.K488T|C6orf10_ENST00000442822.2_Intron			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	490	Lys-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						AAAACTCTCCTTCTTTTCTTG	0.373000													10	180					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121351340	121351340	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:121351340T>C	ENST00000314583.3	-	12	1170	c.1079A>G	c.(1078-1080)tAc>tGc	p.Y360C	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.Y323C	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	360					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		ctcTGCTTCGTACACTGGCTC	0.592000													60	168					0	0	1	0	0
TUFM	7284	broad.mit.edu	37	16	28856724	28856724	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:28856724T>C	ENST00000313511.3	-	3	463	c.325A>G	c.(325-327)Atc>Gtc	p.I109V		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	106						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						TTGATGGTGATACCCCGAGCT	0.552000													53	160					0	0	1	0	0
OAZ1	4946	broad.mit.edu	37	19	2273081	2273081	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2273081G>A	ENST00000583542.3	+	6	764	c.685G>A	c.(685-687)Gag>Aag	p.E229K	OAZ1_ENST00000322297.4_Missense_Mutation_p.E220K|OAZ1_ENST00000582888.3_Missense_Mutation_p.E219K|OAZ1_ENST00000602676.1_Missense_Mutation_p.E221K|OAZ1_ENST00000592727.1_3'UTR			P54368	OAZ1_HUMAN	ornithine decarboxylase antizyme 1	221					polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	ornithine decarboxylase inhibitor activity			endometrium(1)|lung(2)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	L-Ornithine(DB00129)	GTTCGAGAGAGAGTCTTCGGG	0.632000													5	19					0	0	1	0	0
AKAP8	10270	broad.mit.edu	37	19	15472959	15472959	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:15472959T>C	ENST00000269701.2	-	10	1324	c.1264A>G	c.(1264-1266)Agc>Ggc	p.S422G		NM_005858.3	NP_005849.1	O43823	AKAP8_HUMAN	A kinase (PRKA) anchor protein 8	422					signal transduction	nuclear matrix				breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)	26						AGCTTGGTGCTTATGAACCGC	0.537000													3	50					0	0	1	0	0
KIAA1161	57462	broad.mit.edu	37	9	34371428	34371428	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:34371428A>G	ENST00000297625.7	-	2	1637	c.1412T>C	c.(1411-1413)gTa>gCa	p.V471A		NM_020702.3	NP_065753.2	Q6NSJ0	K1161_HUMAN	KIAA1161	505					carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTGGTAGCCTACGCGCACCTC	0.662000													16	41					0	0	1	0	0
ABHD1	84696	broad.mit.edu	37	2	27351946	27351946	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27351946G>T	ENST00000316470.4	+	3	523	c.409G>T	c.(409-411)Gat>Tat	p.D137Y		NM_032604.3	NP_115993.3	Q96SE0	ABHD1_HUMAN	abhydrolase domain containing 1	137			D -> E (in dbSNP:rs6715286).			integral to membrane	carboxylesterase activity			endometrium(1)|kidney(1)|lung(3)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTAGCCAGGATACATACGT	0.557000													31	94					3.69857e-22	3.90823e-22	1	1	0
MAPKBP1	23005	broad.mit.edu	37	15	42107539	42107539	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:42107539G>A	ENST00000457542.2	+	11	1539	c.1253G>A	c.(1252-1254)cGc>cAc	p.R418H	MAPKBP1_ENST00000514566.1_Missense_Mutation_p.R418H|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.R424H|MAPKBP1_ENST00000260357.7_Intron|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.R301H	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	424										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AACACCATCCGCCTGTGGAAC	0.612000													5	83					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50903743	50903743	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:50903743G>A	ENST00000380817.2	-	11	1287	c.1104C>T	c.(1102-1104)cgC>cgT	p.R368R	SBF1_ENST00000348911.6_Silent_p.R369R|SBF1_ENST00000390679.3_Silent_p.R368R	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	368	dDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GGAAGACCGCGCGCAGCTCCT	0.647000													5	11					0	0	1	0	0
NNT	23530	broad.mit.edu	37	5	43650623	43650623	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:43650623T>C	ENST00000264663.5	+	12	1872	c.1651T>C	c.(1651-1653)Tat>Cat	p.Y551H	NNT_ENST00000344920.4_Missense_Mutation_p.Y551H|NNT_ENST00000512996.2_Missense_Mutation_p.Y420H	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	551					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	AGGACATTTGTATCCTTCCAC	0.433000													8	77					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9528450	9528450	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:9528450C>T	ENST00000281419.3	+	22	2498	c.2158C>T	c.(2158-2160)Ccc>Tcc	p.P720S	ASAP2_ENST00000315273.4_Missense_Mutation_p.P720S|ASAP2_ENST00000491413.1_3'UTR	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	720					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						GGAAGACCGGCCCATCAGCTT	0.547000													27	73					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68605148	68605148	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:68605148T>C	ENST00000423218.2	-	24	3031	c.2936A>G	c.(2935-2937)tAc>tGc	p.Y979C	ITGA11_ENST00000315757.7_Missense_Mutation_p.Y979C			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	979					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GATACCATCGTATCTCTCCAG	0.637000													3	43					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131931411	131931411	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:131931411C>T	ENST00000378823.3	+	13	2517	c.1699C>T	c.(1699-1701)Cga>Tga	p.R567*	RAD50_ENST00000265335.6_Nonsense_Mutation_p.R706*	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	706					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding	p.R706G(1)|p.R567G(1)		breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCTAAACTGCGACTTGCTCC	0.438000								Homologous recombination					30	118					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126748859	126748859	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:126748859C>T	ENST00000393409.2	+	27	5013	c.5013C>T	c.(5011-5013)ggC>ggT	p.G1671G	PLXNA1_ENST00000251772.4_Silent_p.G1648G	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1671					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GTGACCGCGGCAGCAAGATGG	0.657000													5	154					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126199426	126199426	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:126199426C>T	ENST00000368357.3	+	6	721	c.369C>T	c.(367-369)acC>acT	p.T123T	NCOA7_ENST00000229634.9_Silent_p.T19T|NCOA7_ENST00000392477.2_Silent_p.T123T	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	123					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		ACCAGGACACCCTAAACTCCA	0.318000													11	29					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195798888	195798888	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:195798888A>T	ENST00000360110.4	-	5	739	c.570T>A	c.(568-570)atT>atA	p.I190I	TFRC_ENST00000420415.1_Silent_p.I109I|TFRC_ENST00000392396.3_Silent_p.I190I|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_5'UTR	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	190					cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		CTTTGACCTGAATCTTAACAA	0.323000			T	BCL6	NHL								5	62					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31497177	31497177	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:31497177T>C	ENST00000330498.3	+	4	450	c.431T>C	c.(430-432)gTg>gCg	p.V144A		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	144					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						TACCTGTCTGTGCTCTCCCTT	0.597000													16	57					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112024217	112024217	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:112024217G>A	ENST00000354650.3	-	8	1174	c.568C>T	c.(568-570)Cgt>Tgt	p.R190C	FYN_ENST00000476769.2_5'UTR|FYN_ENST00000538466.1_Missense_Mutation_p.R190C|FYN_ENST00000229470.5_Missense_Mutation_p.R141C|FYN_ENST00000356013.2_Missense_Mutation_p.R190C|FYN_ENST00000368682.3_Missense_Mutation_p.R190C|FYN_ENST00000368678.4_Missense_Mutation_p.R190C|FYN_ENST00000229471.4_Missense_Mutation_p.R190C|FYN_ENST00000368667.2_Missense_Mutation_p.R190C	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	190	SH2.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCCCAATCACGGATAGAAAGT	0.413000													19	64					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684127	113684127	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:113684127G>A	ENST00000295878.3	-	17	2832	c.2686C>T	c.(2686-2688)Cga>Tga	p.R896*		NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	896										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						AGTTGCTGTCGCCTTTCTTCT	0.413000													39	84					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308431	140308431	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140308431C>T	ENST00000253807.2	+	1	1954	c.1954C>T	c.(1954-1956)Ctg>Ttg	p.L652L	PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHAC1_ENST00000409700.3_Silent_p.L652L|PCDHA5_ENST00000529619.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTGTCACTCTGGGTGTGCT	0.522000													33	92					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158747317	158747317	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:158747317A>G	ENST00000339258.1	-	1	108	c.109T>C	c.(109-111)Ttc>Ctc	p.F37L		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					CAGATGGTGAACAGGTATGCC	0.483000													40	117					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24534907	24534907	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24534907C>T	ENST00000342740.5	+	34	3627	c.3473C>T	c.(3472-3474)gCc>gTc	p.A1158V	LRRC16B_ENST00000334420.7_Intron	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1158										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		CACGGTGTTGCCCTTCCCGGG	0.587000													41	124					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59410844	59410844	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:59410844A>G	ENST00000301645.3	-	2	402	c.265T>C	c.(265-267)Ttg>Ctg	p.L89L		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	89					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CCGTGGCACAACACCTTATGG	0.358000									Neonatal Giant Cell Hepatitis				15	190					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023544	76023544	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:76023544T>A	ENST00000393004.2	-	5	2225	c.2004A>T	c.(2002-2004)agA>agT	p.R668S	FILIP1_ENST00000370020.1_Missense_Mutation_p.R569S|FILIP1_ENST00000237172.7_Missense_Mutation_p.R668S|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	668										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CCTGCTCAGTTCTAAATTTCT	0.423000													6	320					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20781876	20781876	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:20781876T>C	ENST00000380249.1	+	12	1509	c.1145T>C	c.(1144-1146)cTa>cCa	p.L382P	FOCAD_ENST00000338382.6_Missense_Mutation_p.L382P	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	382						integral to membrane	binding										CAGTTGGCTCTAAACCTTTTG	0.418000													27	59					0	0	1	0	0
FAM83E	54854	broad.mit.edu	37	19	49106822	49106822	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49106822G>A	ENST00000263266.3	-	4	1294	c.1105C>T	c.(1105-1107)Cgg>Tgg	p.R369W		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	369										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CGGCTgggccgggccgggggg	0.697000													3	21					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72977772	72977772	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:72977772T>C	ENST00000262209.4	-	4	673	c.466A>G	c.(466-468)Att>Gtt	p.I156V		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	156						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TTAACATCAATAGTTCTATGC	0.348000													14	48					0	0	1	0	0
OLFML3	56944	broad.mit.edu	37	1	114523793	114523793	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:114523793T>C	ENST00000369551.1	+	4	851	c.563T>C	c.(562-564)gTa>gCa	p.V188A	OLFML3_ENST00000320334.4_Missense_Mutation_p.V208A|OLFML3_ENST00000491700.1_3'UTR|OLFML3_ENST00000393300.2_Missense_Mutation_p.V188A			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	208	Olfactomedin-like.				multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCCCCTGGGTAGGCACAGGG	0.567000													19	62					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133748417	133748417	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:133748417A>G	ENST00000318560.5	+	6	1459	c.1078A>G	c.(1078-1080)Atc>Gtc	p.I360V		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	360	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GAAAAACTTCATCCACAGGTA	0.607000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								12	32					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127623000	127623000	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:127623000C>T	ENST00000508053.1	-	60	7854	c.6880_splice	c.e60+1	p.D2294_splice	FBN2_ENST00000262464.4_Splice_Site_p.D2294_splice			P35556	FBN2_HUMAN	fibrillin 2	2294	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GAGGCCTTACCTTTGCACATC	0.438000													4	150					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128724902	128724902	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:128724902G>A	ENST00000296464.3	+	7	1193	c.782G>A	c.(781-783)cGg>cAg	p.R261Q	HSPA4L_ENST00000508776.1_Missense_Mutation_p.R261Q|HSPA4L_ENST00000439123.2_Missense_Mutation_p.R292Q|HSPA4L_ENST00000505726.1_Missense_Mutation_p.R235Q	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	261					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GAAAACTCTCGGGCCTTGTTG	0.373000													19	55					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108031919	108031919	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:108031919G>A	ENST00000278612.8	-	17	3999	c.3894C>T	c.(3892-3894)gaC>gaT	p.D1298D		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	1298					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		ATGTACTACTGTCTTCACTGA	0.498000													25	99					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29041235	29041235	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:29041235C>T	ENST00000282397.4	-	3	444	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	FLT1_ENST00000539099.1_Missense_Mutation_p.E65K|FLT1_ENST00000541932.1_Missense_Mutation_p.E65K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	65	Ig-like C2-type 1.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTCACCATTTCAGGCAAAGAC	0.453000													12	139					0	0	1	0	0
RSPH9	221421	broad.mit.edu	37	6	43638530	43638530	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:43638530C>A	ENST00000372165.4	+	6	780	c.727C>A	c.(727-729)Ctg>Atg	p.L243M	RSPH9_ENST00000372163.4_Silent_p.S225S	NM_001193341.1	NP_001180270.1	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog (Chlamydomonas)	0					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						TCTCAGGGTCCTGGAGCATCC	0.647000									Kartagener syndrome				22	59					3.10358e-05	3.16963e-05	1	1	0
ATP6V1A	523	broad.mit.edu	37	3	113507640	113507640	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:113507640A>T	ENST00000273398.3	+	7	905	c.797A>T	c.(796-798)tAt>tTt	p.Y266F	ATP6V1A_ENST00000538620.1_Missense_Mutation_p.Y233F	NM_001690.3	NP_001681.2	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	266					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTATCCAAGTATTCTAACAGT	0.433000													39	89					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96339120	96339120	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:96339120A>G	ENST00000359246.4	+	1	432	c.65A>G	c.(64-66)gAg>gGg	p.E22G	PHF2_ENST00000375376.4_Missense_Mutation_p.E22G	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	22				FMIECDACKDWFHGSCVGVEEEE -> PRAARPPARPGPTR AAQRRGRAT (in Ref. 2; BAA31637).	liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		TTCATGATCGAGTGCGACGCC	0.756000													8	14					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18548731	18548731	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:18548731A>G	ENST00000399799.1	-	25	3944		c.e25+1			NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1						actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					AAGCATGTATACCTGTGTTTT	0.358000													11	47					0	0	1	0	0
IGLV3-10	28803	broad.mit.edu	37	22	23154644	23154644	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:23154644A>G	ENST00000390315.2	+	0	248																											AGGACAGCAAACGACCCTCCG	0.542000													5	89					0	0	1	0	0
TM7SF3	51768	broad.mit.edu	37	12	27143527	27143527	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27143527C>T	ENST00000343028.4	-	6	949	c.724G>A	c.(724-726)Gtt>Att	p.V242I	TM7SF3_ENST00000542667.1_Intron	NM_016551.2	NP_057635.1	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3	242						integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	18	Colorectal(261;0.0847)					GAGAAGGAAACACTTGTCTTA	0.408000													55	95					0	0	1	0	0
NSUN5P1	155400	broad.mit.edu	37	7	75045945	75045945	+	RNA	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:75045945C>A	ENST00000393633.2	+	0	4672																				large_intestine(1)|lung(1)	2						GTGGAGGACCCTGGGCCCTCA	0.582000													26	106					1.2476e-16	1.31095e-16	1	1	0
ROCK1	6093	broad.mit.edu	37	18	18608856	18608856	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:18608856A>G	ENST00000399799.1	-	10	2032	c.1092T>C	c.(1090-1092)gaT>gaC	p.D364D		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	364	AGC-kinase C-terminal.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					AATTACTAGTATCAATGTCAC	0.338000													31	100					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	712027	712027	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:712027T>A	ENST00000382303.1	+	7	1913	c.1261T>A	c.(1261-1263)Tcc>Acc	p.S421T	KANK1_ENST00000382293.3_Missense_Mutation_p.S263T|KANK1_ENST00000382297.2_Missense_Mutation_p.S421T|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	421					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		AGGCTCCAGGTCCTGTAAGGA	0.552000													28	79					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653369	159653369	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:159653369C>T	ENST00000297267.9	+	11	2025	c.1825C>T	c.(1825-1827)Cgc>Tgc	p.R609C	FNDC1_ENST00000340366.6_Missense_Mutation_p.R546C	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	609						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CACGCAGCCCCGCCCAGGGGC	0.687000													13	48					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28845883	28845883	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:28845883A>G	ENST00000336783.4	+	18	2469	c.2302A>G	c.(2302-2304)Atg>Gtg	p.M768V	ATXN2L_ENST00000395547.2_Missense_Mutation_p.M768V|ATXN2L_ENST00000340394.8_Missense_Mutation_p.M768V|ATXN2L_ENST00000565845.1_3'UTR|ATXN2L_ENST00000325215.6_Missense_Mutation_p.M768V|ATXN2L_ENST00000570200.1_Missense_Mutation_p.M768V|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000564304.1_Missense_Mutation_p.M774V|ATXN2L_ENST00000382686.4_Missense_Mutation_p.M768V	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	768						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CCCGCCGATGATGCAGGCCGC	0.667000													59	179					0	0	1	0	0
MFSD11	79157	broad.mit.edu	37	17	74774350	74774350	+	Silent	SNP	G	G	T	rs143254714	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:74774350G>T	ENST00000588460.1	+	13	3308	c.1266G>T	c.(1264-1266)ggG>ggT	p.G422G	MFSD11_ENST00000590070.1_3'UTR|MFSD11_ENST00000586622.1_Silent_p.G422G|MFSD11_ENST00000336509.4_Silent_p.G422G|MFSD11_ENST00000593181.1_Silent_p.G370G|MFSD11_ENST00000355954.3_Silent_p.G370G|MFSD11_ENST00000590514.1_Silent_p.G422G	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	422						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						TGATATTTGGGTTTTTTGGAA	0.468000													4	106					0.00024832	0.000251724	1	1	0
ATP6V0A2	23545	broad.mit.edu	37	12	124233282	124233282	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124233282A>G	ENST00000330342.3	+	15	2133	c.1885A>G	c.(1885-1887)Aac>Gac	p.N629D		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	629					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TGAATTTATTAACATGTTTTT	0.398000													6	150					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28763274	28763274	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:28763274G>A	ENST00000422425.2	+	12	817	c.773G>A	c.(772-774)cGg>cAg	p.R258Q	PLB1_ENST00000327757.5_Missense_Mutation_p.R247Q	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	247	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GAGACCACCCGGCTGGCCAAG	0.612000													9	39					0	0	1	0	0
PLA2G2A	5320	broad.mit.edu	37	1	20305005	20305005	+	Missense_Mutation	SNP	G	G	A	rs143609918		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:20305005G>A	ENST00000375111.3	-	4	324	c.53C>T	c.(52-54)gCc>gTc	p.A18V	PLA2G2A_ENST00000496748.1_5'UTR|PLA2G2A_ENST00000400520.3_Missense_Mutation_p.A18V	NM_000300.3|NM_001161727.1	NP_000291.1|NP_001155199.1	P14555	PA2GA_HUMAN	phospholipase A2, group IIA (platelets, synovial fluid)	18					defense response to Gram-positive bacterium|lipid catabolic process|low-density lipoprotein particle remodeling|phosphatidic acid metabolic process|positive regulation of inflammatory response|positive regulation of macrophage derived foam cell differentiation	endoplasmic reticulum|extracellular space|membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|phospholipid binding			central_nervous_system(1)|lung(6)|prostate(1)|stomach(1)	9		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000138)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.00032)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ATTCCCATGGGCCTGCAGTAG	0.557000													7	52					0	0	1	0	0
CBX6	23466	broad.mit.edu	37	22	39262377	39262377	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:39262377C>T	ENST00000407418.3	-	5	1199	c.1076G>A	c.(1075-1077)cGc>cAc	p.R359H	CBX6_ENST00000216083.6_Missense_Mutation_p.R341H			O95503	CBX6_HUMAN	chromobox homolog 6	359					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex				large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(58;0.04)					CATCTCGGGGCGCCAGTCCCC	0.662000													16	53					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872491	213872491	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:213872491G>A	ENST00000457361.1	-	8	1342	c.1174C>T	c.(1174-1176)Cga>Tga	p.R392*	IKZF2_ENST00000374319.4_Nonsense_Mutation_p.R366*|IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000342002.2_Nonsense_Mutation_p.R398*|IKZF2_ENST00000451136.2_Nonsense_Mutation_p.R320*|IKZF2_ENST00000421754.2_Nonsense_Mutation_p.R318*|IKZF2_ENST00000434687.1_Nonsense_Mutation_p.R392*|IKZF2_ENST00000374327.4_Nonsense_Mutation_p.R247*	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R392*(1)		NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TCCTGGGGTCGACTCTTTGGT	0.502000													44	130					0	0	1	0	0
EIF2B2	8892	broad.mit.edu	37	14	75475827	75475827	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75475827A>G	ENST00000266126.5	+	8	1072	c.992A>G	c.(991-993)aAt>aGt	p.N331S		NM_014239.3	NP_055054.1	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	331					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(234;0.00661)		ATTGGTGGGAATGCACCTTCC	0.493000													68	224					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9406700	9406700	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9406700C>T	ENST00000591998.1	-	6	1608	c.1380G>A	c.(1378-1380)tcG>tcA	p.S460S	ZNF699_ENST00000308650.3_Silent_p.S460S			Q32M78	ZN699_HUMAN	zinc finger protein 699	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CTCTAAAGGACGAGGGACAAC	0.448000													10	43					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638394	234638394	+	Missense_Mutation	SNP	A	A	C	rs140766748	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:234638394A>C	ENST00000482026.1	+	1	641	c.622A>C	c.(622-624)Atg>Ctg	p.M208L	UGT1A5_ENST00000373414.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000480628.1_Intron	NM_019093.2	NP_061966.1												p.M208L(5)		breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CATGACATTCATGCAAAGGGT	0.443000													5	318					0	0	1	0	0
PROSC	11212	broad.mit.edu	37	8	37632908	37632908	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:37632908A>G	ENST00000328195.3	+	6	573	c.506A>G	c.(505-507)aAc>aGc	p.N169S		NM_007198.3	NP_009129.1	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog (bacterial)	169							pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	GAGCACATAAACGCCAAGTGT	0.478000													67	285					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214239796	214239796	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:214239796G>A	ENST00000331683.5	+	9	990	c.895G>A	c.(895-897)Gcc>Acc	p.A299T	SPAG16_ENST00000447990.1_Missense_Mutation_p.A299T|SPAG16_ENST00000374309.3_Missense_Mutation_p.A205T|SPAG16_ENST00000272898.7_Missense_Mutation_p.A299T	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	299					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TCTTCGTGAAGCCAGGGAACA	0.318000													14	51					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67264864	67264864	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:67264864G>A	ENST00000356404.3	-	14	2209	c.1984C>T	c.(1984-1986)Cgg>Tgg	p.R662W	PITPNM1_ENST00000436757.2_Missense_Mutation_p.R662W|PITPNM1_ENST00000534749.1_Missense_Mutation_p.R662W	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	662					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						GTGCTTGCCCGCCGGGGCTCC	0.672000													20	52					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32750697	32750697	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:32750697T>C	ENST00000421745.2	+	59	12054		c.e59+2			NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TCTTGGCAGGTAATATTCCTC	0.373000													13	64					0	0	1	0	0
EDC3	80153	broad.mit.edu	37	15	74963875	74963875	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:74963875T>C	ENST00000315127.4	-	3	586	c.405A>G	c.(403-405)caA>caG	p.Q135Q	EDC3_ENST00000426797.3_Silent_p.Q135Q|EDC3_ENST00000568176.1_Silent_p.Q135Q	NM_001142444.1|NM_025083.3	NP_001135916.1|NP_079359.2	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	135					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TTGAGCACTGTTGCTGCTGCG	0.507000													22	103					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228901	142228901	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:142228901C>T	ENST00000519067.1	-	4	988	c.685G>A	c.(685-687)Gtc>Atc	p.V229I	SLC45A4_ENST00000024061.3_Missense_Mutation_p.V229I|SLC45A4_ENST00000433583.2_Missense_Mutation_p.V222I|SLC45A4_ENST00000517878.1_Missense_Mutation_p.V280I			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	280					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AAGGCAGGGACGCCGTGCGGC	0.677000													84	200					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512809	125512809	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:125512809G>T	ENST00000373684.1	+	1	791	c.791G>T	c.(790-792)aGa>aTa	p.R264I	OR1L6_ENST00000304720.2_Missense_Mutation_p.R228I			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						ACTGTGCTCAGAATCCCCTCT	0.502000													16	30					6.44725e-10	6.67513e-10	1	1	0
DNAH1	25981	broad.mit.edu	37	3	52422520	52422520	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52422520C>T	ENST00000420323.2	+	58	9519	c.9258C>T	c.(9256-9258)gaC>gaT	p.D3086D		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3086	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGGTGGAGGACGGCATCGCCA	0.617000													6	26					0	0	1	0	0
PLIN2	123	broad.mit.edu	37	9	19118342	19118342	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:19118342T>C	ENST00000276914.2	-	7	1068	c.889A>G	c.(889-891)Act>Gct	p.T297A	PLIN2_ENST00000411567.1_Missense_Mutation_p.T216A	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	297					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						GACTCATCAGTATCATCATAT	0.413000													21	62					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13605598	13605598	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:13605598T>C	ENST00000040738.5	-	10	3061	c.2926A>G	c.(2926-2928)Act>Gct	p.T976A		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	976	Lys-rich.						DNA binding										GAAGAAGCAGTCTCTAATACA	0.378000													16	210					0	0	1	0	0
E4F1	1877	broad.mit.edu	37	16	2285271	2285271	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2285271G>A	ENST00000301727.4	+	14	2101	c.2053G>A	c.(2053-2055)Ggc>Agc	p.G685S	E4F1_ENST00000564139.1_3'UTR|E4F1_ENST00000565090.1_Missense_Mutation_p.G508S	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	685					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GGCTAGCGCCGGCCACCAGAT	0.672000													35	108					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46659508	46659508	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:46659508C>T	ENST00000544460.1	+	1	3897	c.3643C>T	c.(3643-3645)Cct>Tct	p.P1215S	TDRD6_ENST00000316081.6_Missense_Mutation_p.P1215S	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1215					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GTCATATAAACCTCAGATCAA	0.299000													14	53					0	0	1	0	0
TRIM31	11074	broad.mit.edu	37	6	30076801	30076801	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30076801A>G	ENST00000376734.3	-	5	893		c.e5+1		TRIM31-AS1_ENST00000440874.1_RNA|TRIM31_ENST00000485864.1_Splice_Site|TRIM31_ENST00000540829.1_Splice_Site	NM_007028.3	NP_008959.3	Q9BZY9	TRI31_HUMAN	tripartite motif containing 31							mitochondrion	ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(2)	15						GGCCCATCATACCTGCACAAG	0.468000													5	134					0	0	1	0	0
PARP10	84875	broad.mit.edu	37	8	145057500	145057500	+	Missense_Mutation	SNP	G	G	A	rs139166854	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145057500G>A	ENST00000313028.7	-	8	2351	c.2257C>T	c.(2257-2259)Cgc>Tgc	p.R753C	PARP10_ENST00000524918.1_Missense_Mutation_p.R744C|PARP10_ENST00000525773.1_Missense_Mutation_p.R765C	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	753	Myc binding.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGCTCCAGGCGAGCACGCAGC	0.706000													9	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9020058	9020058	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9020058C>T	ENST00000397910.4	-	21	37640	c.37437G>A	c.(37435-37437)gaG>gaA	p.E12479E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12481	SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGGCTCAGCTCCCAGTACA	0.552000													7	338					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	92002325	92002325	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:92002325A>G	ENST00000450295.1	-	12	2082	c.1306T>C	c.(1306-1308)Tat>Cat	p.Y436H	SEMA4D_ENST00000343780.4_Missense_Mutation_p.Y436H|SEMA4D_ENST00000339861.4_Missense_Mutation_p.Y436H|SEMA4D_ENST00000420987.1_Missense_Mutation_p.Y436H|SEMA4D_ENST00000455551.2_Missense_Mutation_p.Y436H|SEMA4D_ENST00000356444.2_Missense_Mutation_p.Y436H|SEMA4D_ENST00000438547.2_Missense_Mutation_p.Y436H|SEMA4D_ENST00000422704.2_Missense_Mutation_p.Y436H			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	436	Sema.				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						ATGACATCATAGACAGTCCCA	0.527000													17	67					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107816895	107816895	+	Missense_Mutation	SNP	G	G	A	rs147348539		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:107816895G>A	ENST00000379028.3	-	27	3601	c.3131C>T	c.(3130-3132)gCa>gTa	p.A1044V	NRCAM_ENST00000379024.4_Missense_Mutation_p.A1025V|NRCAM_ENST00000425651.2_Missense_Mutation_p.A1044V|NRCAM_ENST00000379022.4_Missense_Mutation_p.A1044V|NRCAM_ENST00000351718.4_Missense_Mutation_p.A1028V|NRCAM_ENST00000413765.2_Missense_Mutation_p.A1025V			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	1044	Fibronectin type-III 4.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						AGTTGTTACTGCTTCCTCTGT	0.308000													32	110					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117660540	117660540	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:117660540G>A	ENST00000317775.6	-	26	4640	c.3955C>T	c.(3955-3957)Cgg>Tgg	p.R1319W	NOS1_ENST00000338101.4_Missense_Mutation_p.R1353W|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1319					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCTGGCTCCCGGGAGTAAGCC	0.567000													104	168					0	0	1	0	0
GRWD1	83743	broad.mit.edu	37	19	48956004	48956004	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:48956004C>T	ENST00000253237.5	+	7	1296	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	355						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		GCACGTGGCCCCCGTGACCTC	0.652000													33	112					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539456	94539456	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:94539456A>G	ENST00000289495.5	+	1	247	c.31A>G	c.(31-33)Acc>Gcc	p.T11A	PPP1R9A_ENST00000456331.2_Missense_Mutation_p.T11A|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.T11A|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.T11A|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.T11A|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.T11A	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	11	Actin-binding.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGGTGAACGAACCACTCTCAG	0.408000										HNSCC(28;0.073)			6	37					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247025261	247025261	+	Splice_Site	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:247025261C>A	ENST00000366508.1	-	28	3976	c.3840_splice	c.e28+1	p.G1280_splice	AHCTF1_ENST00000326225.3_Splice_Site_p.G1254_splice|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Splice_Site_p.G1245_splice			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1245	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TCAAACTTACCCCAGGAATCC	0.343000													6	39					8.12818e-05	8.26188e-05	1	1	0
CNTN5	53942	broad.mit.edu	37	11	100170002	100170002	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:100170002T>C	ENST00000524871.1	+	20	2784	c.2494T>C	c.(2494-2496)Tcc>Ccc	p.S832P	CNTN5_ENST00000279463.3_Missense_Mutation_p.S832P|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000528682.1_Missense_Mutation_p.S832P|CNTN5_ENST00000418526.2_Missense_Mutation_p.S758P|CNTN5_ENST00000527185.1_Missense_Mutation_p.S832P	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	832	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTCTGAAGCTTCCAAATTCAT	0.423000													8	51					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113858	42113858	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:42113858A>G	ENST00000457542.2	+	24	3081	c.2795A>G	c.(2794-2796)gAa>gGa	p.E932G	MAPKBP1_ENST00000514566.1_Missense_Mutation_p.E932G|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.E938G|MAPKBP1_ENST00000260357.7_Missense_Mutation_p.E771G|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.E815G	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	938										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCACAAGAGGAAGGGGTCTTT	0.512000													24	142					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380141	147380141	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:147380141T>C	ENST00000240986.4	+	2	112	c.59T>C	c.(58-60)gTc>gCc	p.V20A	GJA8_ENST00000369235.1_Missense_Mutation_p.V20A	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	20					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CACTCCACCGTCATCGGCAGA	0.562000													5	157					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99695980	99695980	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:99695980T>C	ENST00000370597.3	-	3	723	c.368A>G	c.(367-369)gAc>gGc	p.D123G	CRTAC1_ENST00000370591.2_Missense_Mutation_p.D123G|CRTAC1_ENST00000298819.4_Missense_Mutation_p.D123G	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	123						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GCCGTCCCCGTCGATGTCGCA	0.632000													20	78					0	0	1	0	0
CTCF	10664	broad.mit.edu	37	16	67645477	67645477	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67645477A>G	ENST00000264010.4	+	3	1186	c.742A>G	c.(742-744)Aat>Gat	p.N248D	CTCF_ENST00000401394.1_Intron	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	248					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGTGGTTGGTAATATGAAGCC	0.393000													31	96					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75058827	75058827	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:75058827A>T	ENST00000310715.3	-	15	1680	c.1560T>A	c.(1558-1560)aaT>aaA	p.N520K	TTC18_ENST00000340329.3_Intron|TTC18_ENST00000401621.2_Missense_Mutation_p.N520K|TTC18_ENST00000394865.1_Missense_Mutation_p.N520K|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000493787.1_5'UTR	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	520							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CTCTAGAAATATTCTTGATCT	0.413000													22	50					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45802679	45802679	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:45802679T>C	ENST00000357450.4	-	3	365	c.366A>G	c.(364-366)gaA>gaG	p.E122E	SMC1B_ENST00000404354.3_Silent_p.E122E	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	122					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TGCCTATCTTTTCCAACTCTG	0.299000													23	69					0	0	1	0	0
BRF2	55290	broad.mit.edu	37	8	37704452	37704452	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:37704452A>G	ENST00000220659.6	-	3	576	c.456T>C	c.(454-456)acT>acC	p.T152T	BRF2_ENST00000520601.1_Silent_p.T152T	NM_018310.3	NP_060780.2	Q9HAW0	BRF2_HUMAN	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	152					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	12		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			TCTGCATGTAAGTGCTAGAAA	0.527000													123	390					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017983	1017983	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1017983T>C	ENST00000421673.2	-	31	4868	c.4818A>G	c.(4816-4818)tcA>tcG	p.S1606S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1606	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGAGGGTGTGATGGGGTTG	0.547000													23	465					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93521521	93521521	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:93521521G>A	ENST00000394196.4	+	21	3703	c.2635G>A	c.(2635-2637)Gcg>Acg	p.A879T	CHD2_ENST00000557381.1_Missense_Mutation_p.A879T	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	879	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TTTGGCTTCAGCGGACACAGT	0.493000													25	75					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99771297	99771297	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:99771297A>G	ENST00000370185.3	+	7	1520	c.1023A>G	c.(1021-1023)agA>agG	p.R341R	LPPR4_ENST00000370184.1_Silent_p.R183R|LPPR4_ENST00000457765.1_Silent_p.R283R	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		341							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TTCAGCACAGAGACGCCCTCA	0.448000													39	105					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2898720	2898720	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:2898720T>C	ENST00000254695.8	+	13	1094	c.1004T>C	c.(1003-1005)gTt>gCt	p.V335A	RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.V316A|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.V335A|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.V320A	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	335	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						ATGTTTCACGTTTCCACAAAG	0.587000													41	136					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8201971	8201971	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:8201971T>C	ENST00000162391.3	+	9	2486	c.1341T>C	c.(1339-1341)agT>agC	p.S447S	FOXJ2_ENST00000428177.2_Silent_p.S447S	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	447					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		TGATGGAGAGTCTACGACAGG	0.522000													51	194					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113638610	113638610	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:113638610A>G	ENST00000361127.4	+	7	1116	c.918A>G	c.(916-918)gcA>gcG	p.A306A		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	306						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GCCCTGATGCATGGGAGTTCT	0.448000													10	46					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3128514	3128514	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:3128514C>A	ENST00000263650.7	-	9	1197	c.1038G>T	c.(1036-1038)caG>caT	p.Q346H	OSBPL5_ENST00000348039.5_Missense_Mutation_p.Q278H|OSBPL5_ENST00000542243.1_Intron|OSBPL5_ENST00000525498.1_Missense_Mutation_p.Q257H|OSBPL5_ENST00000389989.3_Missense_Mutation_p.Q278H	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	346					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCTCCTGGACCTGCTCCACAT	0.672000													32	117					3.03874e-20	3.202e-20	1	1	0
MROH2B	133558	broad.mit.edu	37	5	41018457	41018457	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:41018457T>C	ENST00000399564.4	-	27	3199	c.2749A>G	c.(2749-2751)Aca>Gca	p.T917A	MROH2B_ENST00000506092.2_Missense_Mutation_p.T472A	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ATATCATTTGTCAGCACTTTC	0.408000													7	21					0	0	1	0	0
LDLRAD3	143458	broad.mit.edu	37	11	36103271	36103271	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:36103271C>T	ENST00000315571.5	+	3	283	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C	LDLRAD3_ENST00000528989.1_Missense_Mutation_p.R39C|LDLRAD3_ENST00000524419.1_Missense_Mutation_p.R39C	NM_174902.2	NP_777562.1	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain containing 3	88	LDL-receptor class A 2.					integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(7)|skin(1)	28	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				CATCATTGGTCGCTTCCGGTG	0.517000													37	94					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	124029909	124029909	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:124029909A>G	ENST00000422452.2	-	2	462	c.399T>C	c.(397-399)agT>agC	p.S133S	TENM1_ENST00000371130.3_Silent_p.S133S	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ACAAACAGGAACTATGCTCTG	0.458000													73	102					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203026055	203026055	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:203026055G>A	ENST00000367240.2	+	18	2848	c.2321G>A	c.(2320-2322)aGt>aAt	p.S774N	PPFIA4_ENST00000599966.1_Missense_Mutation_p.S289N|PPFIA4_ENST00000295706.4_Missense_Mutation_p.S289N|PPFIA4_ENST00000414050.2_Missense_Mutation_p.S502N|PPFIA4_ENST00000447715.2_Missense_Mutation_p.S773N|PPFIA4_ENST00000272198.6_Missense_Mutation_p.S289N			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	289					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						ATCCAGCTGAGTCGGGATGGA	0.612000													17	72					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196434491	196434491	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:196434491A>G	ENST00000367433.5	-	8	671	c.570T>C	c.(568-570)cgT>cgC	p.R190R	KCNT2_ENST00000294725.8_Silent_p.R190R|KCNT2_ENST00000367431.4_Silent_p.R190R|KCNT2_ENST00000451324.2_5'UTR|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	190						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CAGACTGTGTACGCTGAATGG	0.279000													15	52					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27222538	27222538	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:27222538T>C	ENST00000230582.3	+	10	1232	c.1217T>C	c.(1216-1218)cTa>cCa	p.L406P	PRSS16_ENST00000421826.2_Missense_Mutation_p.L149P|PRSS16_ENST00000377456.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	406					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CAGCTAGACCTATGTGAGCAG	0.557000													6	163					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216284010	216284010	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:216284010G>T	ENST00000354785.4	-	12	2143	c.1774C>A	c.(1774-1776)Cgt>Agt	p.R592S	FN1_ENST00000421182.1_Missense_Mutation_p.R592S|FN1_ENST00000359671.1_Missense_Mutation_p.R592S|FN1_ENST00000357867.4_Missense_Mutation_p.R592S|FN1_ENST00000357009.2_Missense_Mutation_p.R592S|FN1_ENST00000336916.4_Missense_Mutation_p.R592S|FN1_ENST00000323926.6_Missense_Mutation_p.R592S|FN1_ENST00000345488.5_Missense_Mutation_p.R592S|FN1_ENST00000346544.3_Missense_Mutation_p.R592S|FN1_ENST00000356005.4_Missense_Mutation_p.R592S|FN1_ENST00000426059.1_Missense_Mutation_p.R592S|FN1_ENST00000432072.2_Missense_Mutation_p.R592S|FN1_ENST00000446046.1_Missense_Mutation_p.R592S|FN1_ENST00000443816.1_Missense_Mutation_p.R592S			P02751	FINC_HUMAN	fibronectin 1	592	Collagen-binding.|Fibronectin type-I 9.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAATGCCACGGCCATAGCAG	0.458000													16	74					0.000422831	0.000428339	1	1	0
PIK3CA	5290	broad.mit.edu	37	3	178942528	178942528	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:178942528C>T	ENST00000263967.3	+	16	2492	c.2335C>T	c.(2335-2337)Ctg>Ttg	p.L779L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	779					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAAAAGGCCACTGTGGTTGAA	0.353000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			18	92					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22013987	22013987	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:22013987T>C	ENST00000261200.4	-	19	2341	c.2342A>G	c.(2341-2343)tAc>tGc	p.Y781C	ABCC9_ENST00000345162.2_Missense_Mutation_p.Y745C|RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000261201.4_Missense_Mutation_p.Y781C	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	781	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GACAGCTTTGTACCTTTGGGA	0.328000													19	63					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60470078	60470078	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:60470078A>G	ENST00000360469.5	+	8	1251	c.1163A>G	c.(1162-1164)aAc>aGc	p.N388S	CDH4_ENST00000543233.1_Missense_Mutation_p.N314S	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	388	Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTGAATGACAACCCGCCAGAA	0.567000													50	132					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129962361	129962361	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:129962361T>C	ENST00000222482.4	+	11	1139	c.1111T>C	c.(1111-1113)Tat>Cat	p.Y371H	CPA4_ENST00000493259.1_Missense_Mutation_p.Y267H|CPA4_ENST00000445470.2_Missense_Mutation_p.Y338H	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	371					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					CGACTGGGCATATGACAACGG	0.527000													4	155					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36975950	36975950	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:36975950T>A	ENST00000282516.8	+	9	1440	c.941T>A	c.(940-942)aTc>aAc	p.I314N	NIPBL_ENST00000504430.1_3'UTR|NIPBL_ENST00000448238.2_Missense_Mutation_p.I314N	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	314					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CCACCAGATATCTTGCTAGAT	0.373000													21	116					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589601	140589601	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140589601C>A	ENST00000239450.2	+	1	1311	c.1122C>A	c.(1120-1122)gaC>gaA	p.D374E	PCDHB12_ENST00000541609.1_Missense_Mutation_p.D37E	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		374	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGACAGAGACTCTGGGGACA	0.443000													15	64					6.31663e-08	6.50258e-08	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11738013	11738013	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:11738013A>G	ENST00000262442.3	+	49	9373	c.9305A>G	c.(9304-9306)gAa>gGa	p.E3102G	DNAH9_ENST00000454412.2_Missense_Mutation_p.E3102G	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3102	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGAAAAATGAAGATGCAGAC	0.507000													11	29					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88272527	88272527	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:88272527T>C	ENST00000337006.4	-	9	981	c.520A>G	c.(520-522)Ata>Gta	p.I174V	AGTPBP1_ENST00000376080.1_Missense_Mutation_p.I174V|AGTPBP1_ENST00000357081.3_Silent_p.G244G|AGTPBP1_ENST00000432218.1_Silent_p.G82G|AGTPBP1_ENST00000376081.4_Intron|AGTPBP1_ENST00000376083.3_Silent_p.G244G|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000376109.3_Silent_p.G296G			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	0					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						CTTGGACATATCCTCTGTCTA	0.343000													3	34					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20355487	20355487	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:20355487T>C	ENST00000396134.2	-	7	1412	c.1289A>G	c.(1288-1290)gAa>gGa	p.E430G	UMOD_ENST00000396138.4_Missense_Mutation_p.E446G|UMOD_ENST00000302509.4_Missense_Mutation_p.E397G|UMOD_ENST00000396142.2_Missense_Mutation_p.E397G|UMOD_ENST00000424589.1_Missense_Mutation_p.E430G|UMOD_ENST00000570689.1_Missense_Mutation_p.E397G	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	397	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GGCATGGGTTTCATTCCTCTG	0.517000													17	61					0	0	1	0	0
BST1	683	broad.mit.edu	37	4	15716967	15716967	+	Silent	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:15716967A>C	ENST00000382346.3	+	6	688	c.639A>C	c.(637-639)ggA>ggC	p.G213G	BST1_ENST00000265016.4_Silent_p.G198G			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	198					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						AGCCAACAGGAGCCTATCCCA	0.373000													8	41					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21836475	21836475	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21836475T>C	ENST00000216297.2	-	7	1246	c.908A>G	c.(907-909)aAc>aGc	p.N303S		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	303					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GAGCAAAAAGTTATAATTTTC	0.408000													9	99					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67316710	67316710	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:67316710A>G	ENST00000355520.5	-	19	2328		c.e19+1		OPHN1_ENST00000484842.1_Splice_Site|OPHN1_ENST00000540071.1_Splice_Site	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1						axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						GAAAATGCATACCTTGCCAAA	0.478000													7	77					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104376936	104376936	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:104376936C>T	ENST00000392872.3	+	6	871	c.637C>T	c.(637-639)Cgt>Tgt	p.R213C	TDG_ENST00000544861.1_Missense_Mutation_p.R70C|TDG_ENST00000266775.9_Missense_Mutation_p.R209C|TDG_ENST00000542036.1_Intron	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	213					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TGAAGGAGGACGTATTCTAGT	0.249000								Base excision repair (BER), DNA glycosylases					47	268					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19423102	19423102	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:19423102A>G	ENST00000261537.6	+	14	2237	c.1973A>G	c.(1972-1974)aAc>aGc	p.N658S	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	658					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			GGTAATGCAAACCTGGATATC	0.353000													10	21					0	0	1	0	0
B3GNT4	79369	broad.mit.edu	37	12	122691149	122691149	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:122691149T>C	ENST00000535274.1	+	1	2003	c.276T>C	c.(274-276)gaT>gaC	p.D92D	B3GNT4_ENST00000546192.1_Silent_p.D92D|B3GNT4_ENST00000545141.1_Intron|B3GNT4_ENST00000324189.4_Silent_p.D117D			Q9C0J1	B3GN4_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4	117					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000297)|Epithelial(86;0.000497)|BRCA - Breast invasive adenocarcinoma(302;0.222)		GTTCCAAGGATACCTTCTTGC	0.607000													6	427					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481581	140481581	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140481581G>A	ENST00000231130.2	+	1	1348	c.1348G>A	c.(1348-1350)Gcc>Acc	p.A450T	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		450	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAACGCCCCCGCCTTCACCCA	0.562000													84	214					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56180610	56180610	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:56180610G>A	ENST00000399503.3	+	16	3939	c.3939G>A	c.(3937-3939)acG>acA	p.T1313T		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1313	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TGGGAGCCACGTGTGAGAAGA	0.363000													6	39					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41977350	41977350	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:41977350A>G	ENST00000301831.4	-	4	783	c.321T>C	c.(319-321)agT>agC	p.S107S	ULK4_ENST00000420927.1_Silent_p.S107S	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	107	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GATGTAATCCACTAATCAGGT	0.358000													10	96					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40660731	40660731	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:40660731A>G	ENST00000454349.2	+	5	708	c.497A>G	c.(496-498)aAt>aGt	p.N166S	TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000402203.1_Intron|TNRC6B_ENST00000335727.8_Missense_Mutation_p.N166S	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	166					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						AATTATGCAAATTCCACTTGG	0.488000													22	36					0	0	1	0	0
IZUMO2	126123	broad.mit.edu	37	19	50666224	50666224	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50666224T>C	ENST00000293405.3	-	1	228	c.228A>G	c.(226-228)aaA>aaG	p.K76K		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	76						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						ACGCACCCACTTTCCCCACAA	0.687000													24	73					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70639566	70639566	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:70639566C>T	ENST00000322773.4	+	6	742	c.640C>T	c.(640-642)Cga>Tga	p.R214*		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	214	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TATTGCTACGCGAGCTTCAGA	0.363000													30	91					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28602353	28602353	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:28602353C>T	ENST00000434452.1	-	7	1045	c.891G>A	c.(889-891)gtG>gtA	p.V297V	DSC3_ENST00000360428.4_Silent_p.V297V	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	297	Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TGCTGGGATGCACAGAAAAGA	0.483000													24	79					0	0	1	0	0
IMPACT	55364	broad.mit.edu	37	18	22020584	22020584	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:22020584T>C	ENST00000284202.4	+	6	631		c.e6+2			NM_018439.3	NP_060909.1	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein											endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					CTCGGACAGGTATAATGTTAC	0.338000													32	102					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2408097	2408097	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:2408097C>T	ENST00000381223.4	-	2	867	c.664G>A	c.(664-666)Gcc>Acc	p.A222T	ZBED1_ENST00000381218.3_Missense_Mutation_p.A222T|DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381222.2_Missense_Mutation_p.A222T	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	222						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAGTTGGGGGCGCCCAGGCCC	0.647000													74	203					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55708058	55708058	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55708058C>G	ENST00000376350.3	-	10	2111	c.2089G>C	c.(2089-2091)Gag>Cag	p.E697Q	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Missense_Mutation_p.E519Q	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	697	Fibronectin type-III 8.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		ACCTCCAACTCAAAGGCCTCG	0.617000													28	54					0	0	1	0	0
FBXL4	26235	broad.mit.edu	37	6	99353378	99353378	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:99353378G>A	ENST00000369244.2	-	6	1455	c.1027C>T	c.(1027-1029)Cgc>Tgc	p.R343C	FBXL4_ENST00000229971.1_Missense_Mutation_p.R343C			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	343					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		AGAGTGCAGCGAGACTGTAGA	0.448000													40	114					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066398	73066398	+	RNA	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:73066398G>T	ENST00000429829.1	-	0	6190					NR_001564.2																						GTGCGATTACGCACATAAATG	0.473000													37	37					4.14481e-20	4.36647e-20	1	1	0
CPB2	1361	broad.mit.edu	37	13	46632473	46632473	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:46632473T>C	ENST00000181383.4	-	9	856	c.840A>G	c.(838-840)ggA>ggG	p.G280G	CPB2-AS1_ENST00000415033.2_RNA|CPB2-AS1_ENST00000606243.1_RNA|CPB2_ENST00000439329.3_Silent_p.G243G|CPB2-AS1_ENST00000606991.1_RNA|CPB2-AS1_ENST00000606351.1_RNA	NM_001872.3	NP_001863.3	Q96IY4	CBPB2_HUMAN	carboxypeptidase B2 (plasma)	280					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(3)|liver(1)|lung(9)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		CAGGATAAAGTCCACAGTAGG	0.418000													4	113					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118497252	118497252	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:118497252T>C	ENST00000349139.4	+	23	2456		c.e23+2		SPAG17_ENST00000336338.5_Intron	NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AGTATCTCAGTGAGTAAAATG	0.363000													22	90					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35778820	35778820	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:35778820C>T	ENST00000187397.4	+	16	2066	c.1610C>T	c.(1609-1611)cCg>cTg	p.P537L	ARPP21_ENST00000458225.1_Missense_Mutation_p.P503L|ARPP21_ENST00000337271.5_Missense_Mutation_p.P483L|ARPP21_ENST00000417925.1_Missense_Mutation_p.P503L|ARPP21_ENST00000444190.1_Missense_Mutation_p.P483L	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	537	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GTCCAGCCACCGCAGCCACAG	0.642000													13	51					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10098008	10098008	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:10098008G>A	ENST00000380861.4	+	18	2836	c.2445G>A	c.(2443-2445)gcG>gcA	p.A815A	WWC3_ENST00000454666.1_Silent_p.A815A	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	815										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						GTTGGCAAGCGGACTCGGTGG	0.547000													4	86					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17740047	17740047	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17740047A>G	ENST00000428389.2	-	32	4017		c.e32+1		UNC13A_ENST00000552293.1_Splice_Site|UNC13A_ENST00000519716.2_Splice_Site|UNC13A_ENST00000551649.1_Splice_Site|UNC13A_ENST00000252773.7_Splice_Site|UNC13A_ENST00000550896.1_Splice_Site			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CCCTCAGGTCACCACTTTCTC	0.572000													5	22					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9680546	9680546	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:9680546T>C	ENST00000330255.4	-	4	550	c.538A>G	c.(538-540)Atc>Gtc	p.I180V	DHRS7C_ENST00000571134.1_Missense_Mutation_p.I179V	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	180						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TTCCCTTGGATATTATTCACT	0.413000													7	47					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134071473	134071473	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:134071473A>G	ENST00000264360.4	+	1	1004	c.178A>G	c.(178-180)Agg>Ggg	p.R60G		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	60	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GCCCAACTCAAGGACCCCTTA	0.527000													5	168					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54657010	54657010	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54657010C>T	ENST00000358389.3	+	17	2441	c.1587C>T	c.(1585-1587)cgC>cgT	p.R529R	CNOT3_ENST00000496327.1_Intron|CNOT3_ENST00000406403.1_Intron|CNOT3_ENST00000221232.5_Intron			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	336	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGCTCACCCGCGGCCCCTCCC	0.652000													17	48					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2347421	2347421	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2347421G>A	ENST00000301732.5	-	17	2872	c.2172C>T	c.(2170-2172)gaC>gaT	p.D724D	ABCA3_ENST00000382381.3_Silent_p.D666D	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	724	ABC transporter 1.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				GGTCAGCCTCGTCCATGAAGT	0.617000													42	157					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3350059	3350059	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3350059A>T	ENST00000396862.1	-	2	2384	c.556T>A	c.(556-558)Tca>Aca	p.S186T	TIGD7_ENST00000268674.2_Missense_Mutation_p.S186T	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	186	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						tctggcattgacttccaaaag	0.403000													62	156					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73450159	73450159	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:73450159G>A	ENST00000263666.4	-	5	1282	c.1166_splice	c.e5-1	p.H390_splice	PDZRN3_ENST00000462146.2_Splice_Site_p.H47_splice|PDZRN3_ENST00000466348.1_5'UTR|PDZRN3_ENST00000535920.1_Splice_Site_p.H112_splice|PDZRN3_ENST00000479530.1_Splice_Site_p.H107_splice|PDZRN3_ENST00000466780.1_Splice_Site_p.H47_splice	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	390							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCTGAGGGATGCCTGAAAAGA	0.478000													7	94					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	59064256	59064256	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:59064256T>C	ENST00000507116.1	-	1	215	c.80A>G	c.(79-81)gAa>gGa	p.E27G	PDE4D_ENST00000546160.1_Intron|PDE4D_ENST00000340635.6_Intron|PDE4D_ENST00000502484.2_Intron|PDE4D_ENST00000502575.1_Missense_Mutation_p.E27G	NM_001197218.1	NP_001184147.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	0					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CACAAGGTCTTCGTTCAGCCA	0.493000													47	117					0	0	1	0	0
MIPOL1	145282	broad.mit.edu	37	14	37777705	37777705	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:37777705G>A	ENST00000327441.7	+	10	1275	c.809G>A	c.(808-810)cGg>cAg	p.R270Q	MIPOL1_ENST00000539062.2_Missense_Mutation_p.R239Q|MIPOL1_ENST00000556451.1_Missense_Mutation_p.R239Q|MIPOL1_ENST00000537471.1_Missense_Mutation_p.R270Q|MIPOL1_ENST00000536774.1_Missense_Mutation_p.R89Q|MIPOL1_ENST00000396294.2_Missense_Mutation_p.R270Q|MIPOL1_ENST00000545536.1_Missense_Mutation_p.R239Q	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	270										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		ATAGAAGAACGGGATGCTGCC	0.348000													33	90					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687091	21687091	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:21687091A>T	ENST00000398485.2	+	2	356	c.302A>T	c.(301-303)gAg>gTg	p.E101V	PAX1_ENST00000460221.1_Intron|PAX1_ENST00000444366.2_Missense_Mutation_p.E77V	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	101	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						ACGTATGGCGAGGTGAACCAG	0.672000													17	75					0	0	1	0	0
NR0B1	190	broad.mit.edu	37	X	30326381	30326381	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:30326381T>C	ENST00000378970.4	-	1	1334	c.1100A>G	c.(1099-1101)aAa>aGa	p.K367R	NR0B1_ENST00000453287.1_Missense_Mutation_p.K367R|NR0B1_ENST00000378963.1_Missense_Mutation_p.K72R	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	367	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	ACTCCAGCATTTGGAAAGAAA	0.607000											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	63					0	0	1	0	0
NUTM2A	728118	broad.mit.edu	37	10	88988124	88988124	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:88988124C>A	ENST00000381689.4	+	2	818	c.487C>A	c.(487-489)Ccg>Acg	p.P163T	NUTM2A-AS1_ENST00000451940.2_RNA|NUTM2A_ENST00000381707.2_Missense_Mutation_p.P163T					NUT family member 2A																		AGCACACGGGCCGCTCCTTGT	0.697000													19	70					1.50039e-11	1.55951e-11	1	1	0
ASPG	374569	broad.mit.edu	37	14	104570983	104570983	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:104570983T>A	ENST00000551177.1	+	9	1053	c.961T>A	c.(961-963)Tca>Aca	p.S321T	ASPG_ENST00000455920.2_Missense_Mutation_p.S321T|ASPG_ENST00000546892.2_Missense_Mutation_p.S321T	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	321	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						CGGCGTCATCTCAGGCTTCGA	0.682000													5	27					0	0	1	0	0
YRDC	79693	broad.mit.edu	37	1	38272869	38272869	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:38272869T>C	ENST00000373044.2	-	2	412	c.408A>G	c.(406-408)gtA>gtG	p.V136V	C1orf122_ENST00000373043.1_5'UTR	NM_024640.3	NP_078916.3	Q86U90	YRDC_HUMAN	yrdC N(6)-threonylcarbamoyltransferase domain containing	136	YrdC-like.				negative regulation of transport	membrane|mitochondrion				lung(2)|upper_aerodigestive_tract(1)	3	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GCCCCTCAGGTACTCTCACAC	0.507000													29	59					0	0	1	0	0
ZNF584	201514	broad.mit.edu	37	19	58928590	58928590	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58928590T>C	ENST00000306910.4	+	4	1228	c.705T>C	c.(703-705)gtT>gtC	p.V235V	ZNF584_ENST00000593920.1_Silent_p.V190V|ZNF584_ENST00000599238.1_3'UTR	NM_173548.1	NP_775819.1	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		ACCAGAAGGTTCACACAGGCA	0.458000													18	63					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151531957	151531957	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:151531957A>G	ENST00000232892.6	+	1	133	c.7A>G	c.(7-9)Aga>Gga	p.R3G	RP11-454C18.2_ENST00000483843.2_RNA|AADAC_ENST00000488869.1_Missense_Mutation_p.R3G|RP11-454C18.2_ENST00000475855.1_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	3				R -> M (in Ref. 6; AA sequence).	positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CACCATGGGAAGAAAATCGCT	0.428000													43	106					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93979297	93979297	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:93979297A>G	ENST00000369303.4	-	7	1715	c.1531T>C	c.(1531-1533)Tat>Cat	p.Y511H		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	511	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGGAAAACATACACTGTTCCT	0.398000													7	134					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125528100	125528100	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:125528100G>A	ENST00000241305.3	-	9	1395	c.1241C>T	c.(1240-1242)aCg>aTg	p.T414M	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	414					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GTGAATCCGCGTCTCCTCCAC	0.627000													34	111					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10216005	10216005	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10216005C>T	ENST00000418404.3	-	30	4414	c.4251G>A	c.(4249-4251)tcG>tcA	p.S1417S	MYH13_ENST00000570743.1_Silent_p.S1417S|MYH13_ENST00000252172.4_Silent_p.S1417S			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1417					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TTTTCTCCAACGATGCGCACT	0.552000													5	24					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73811420	73811420	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:73811420C>T	ENST00000223398.6	+	14	3064	c.2737C>T	c.(2737-2739)Cgg>Tgg	p.R913W	CLIP2_ENST00000361545.5_Missense_Mutation_p.R878W|CLIP2_ENST00000395060.1_Missense_Mutation_p.R913W	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	913						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						GAACGAACTGCGGGTGTTGCT	0.617000													30	64					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7046509	7046509	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:7046509A>G	ENST00000356654.4	+	5	2316	c.2079A>G	c.(2077-2079)ggA>ggG	p.G693G	ATN1_ENST00000396684.2_Silent_p.G693G	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	693					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						CCACCGTGGGACCTGGGCCCC	0.736000													5	9					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323233	31323233	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:31323233C>T	ENST00000265071.2	+	12	2456	c.2191C>T	c.(2191-2193)Cca>Tca	p.P731S		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	731					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CACTGCCCCGCCATACGACTC	0.547000													15	49					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14875330	14875330	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14875330C>T	ENST00000315576.3	-	11	1450	c.999G>A	c.(997-999)ctG>ctA	p.L333L	EMR2_ENST00000353876.1_Silent_p.L240L|EMR2_ENST00000392964.3_Silent_p.L72L|EMR2_ENST00000601345.1_Silent_p.L333L|EMR2_ENST00000392967.2_Silent_p.L333L|EMR2_ENST00000346057.1_Silent_p.L284L|EMR2_ENST00000392965.3_Silent_p.L333L|EMR2_ENST00000595839.1_Silent_p.L191L|EMR2_ENST00000353005.1_Silent_p.L191L|EMR2_ENST00000596991.2_Silent_p.L333L|EMR2_ENST00000594294.1_Silent_p.L284L|EMR2_ENST00000594076.1_Silent_p.L240L	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	333					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						GGCCATCCAGCAGGTGACTGG	0.602000													13	60					0	0	1	0	0
GPR25	2848	broad.mit.edu	37	1	200842781	200842781	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:200842781C>T	ENST00000304244.2	+	1	699	c.616C>T	c.(616-618)Ctg>Ttg	p.L206L		NM_005298.2	NP_005289.2	O00155	GPR25_HUMAN	G protein-coupled receptor 25	206	Poly-Leu.					integral to plasma membrane				large_intestine(1)|lung(2)|ovary(1)|skin(1)	5						CAGCTTGCTGCTGCTGCTGCT	0.726000													4	33					0	0	1	0	0
ACD	65057	broad.mit.edu	37	16	67691737	67691737	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67691737C>T	ENST00000219251.8	-	11	1806	c.1475G>A	c.(1474-1476)cGt>cAt	p.R492H	ACD_ENST00000393919.4_Missense_Mutation_p.R495H	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	495					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		AGAACCATCACGATGCCTCTT	0.582000													24	68					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577566	7577566	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7577566T>C	ENST00000420246.2	-	7	847	c.715A>G	c.(715-717)Aac>Gac	p.N239D	TP53_ENST00000359597.4_Missense_Mutation_p.N239D|TP53_ENST00000455263.2_Missense_Mutation_p.N239D|TP53_ENST00000445888.2_Missense_Mutation_p.N239D|TP53_ENST00000269305.4_Missense_Mutation_p.N239D|TP53_ENST00000413465.2_Missense_Mutation_p.N239D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	239	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		N -> D (in sporadic cancers; somatic mutation).|N -> H (in a sporadic cancer; somatic mutation).|N -> I (in a sporadic cancer; somatic mutation).|N -> K (in sporadic cancers; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> T (in sporadic cancers; somatic mutation).|N -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N239D(33)|p.N239fs*25(12)|p.0?(8)|p.N239Y(6)|p.N239fs*1(5)|p.?(5)|p.M237_N239delMCN(4)|p.N239_C242delNSSC(3)|p.N239fs*8(2)|p.N239_S240delNS(2)|p.N239fs*26(1)|p.N146D(1)|p.N146fs*1(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.M144_N146delMCN(1)|p.C238fs*21(1)|p.H233fs*6(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGAACTGTTACACATGTAG	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	62					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67205086	67205086	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:67205086C>T	ENST00000371037.4	+	22	2177	c.2100C>T	c.(2098-2100)agC>agT	p.S700S	SGIP1_ENST00000237247.6_Silent_p.S731S|SGIP1_ENST00000371035.3_Silent_p.S490S|SGIP1_ENST00000371036.3_Silent_p.S502S|SGIP1_ENST00000435165.2_Silent_p.S205S|SGIP1_ENST00000371039.1_Silent_p.S503S	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	700					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AGCCTTCAAGCACTGACCTGC	0.502000													10	37					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31522690	31522690	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:31522690C>T	ENST00000331075.5	+	4	1526	c.1477C>T	c.(1477-1479)Ccc>Tcc	p.P493S	INPP5J_ENST00000404390.3_Missense_Mutation_p.P125S|INPP5J_ENST00000405300.1_Missense_Mutation_p.P126S|INPP5J_ENST00000412277.2_Missense_Mutation_p.P426S|INPP5J_ENST00000400294.2_Missense_Mutation_p.P126S			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	493	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						TGCGCTAGGGCCCTTCAACTT	0.607000													57	216					0	0	1	0	0
TASP1	55617	broad.mit.edu	37	20	13550198	13550198	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:13550198A>G	ENST00000337743.4	-	7	644	c.524T>C	c.(523-525)gTa>gCa	p.V175A	TASP1_ENST00000480436.1_5'UTR|TASP1_ENST00000539805.1_Intron	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	175					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						TCCATGATCTACTGCCCATCT	0.318000													14	38					0	0	1	0	0
SCGB2B2	284402	broad.mit.edu	37	19	35085174	35085174	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:35085174T>C	ENST00000601241.1	-	3	2252	c.152A>G	c.(151-153)aAc>aGc	p.N51S	SCGB2B2_ENST00000595326.1_Intron|SCGB2B2_ENST00000379204.2_Missense_Mutation_p.N51S			Q4G0G5	SCGBL_HUMAN	secretoglobin, family 2B, member 2	51						extracellular region	binding										GGGACTGGGGTTGTAACGAGC	0.493000													37	111					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24428137	24428137	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:24428137G>A	ENST00000355123.4	-	38	5151	c.4708C>T	c.(4708-4710)Cgc>Tgc	p.R1570C	ITSN2_ENST00000361999.3_Missense_Mutation_p.R1543C	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1570	C2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCATCAGGCGCCCAATGCCT	0.463000													30	70					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12460258	12460258	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:12460258T>C	ENST00000358136.3	+	61	11785	c.11655T>C	c.(11653-11655)ggT>ggC	p.G3885G	VPS13D_ENST00000496628.1_3'UTR|VPS13D_ENST00000356315.4_Silent_p.G3860G	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3884					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGCTCATTGGTACCACGCAGC	0.512000													25	68					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113856847	113856847	+	Missense_Mutation	SNP	C	C	T	rs139246177		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:113856847C>T	ENST00000504030.2	+	6	1100	c.655C>T	c.(655-657)Cgg>Tgg	p.R219W	HTR3A_ENST00000355556.2_Missense_Mutation_p.R225W|HTR3A_ENST00000506841.2_Missense_Mutation_p.R219W|HTR3A_ENST00000375498.2_Missense_Mutation_p.R225W|HTR3A_ENST00000535865.1_Intron|HTR3A_ENST00000299961.5_Missense_Mutation_p.R204W			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	219					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity	p.R219W(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GCCCTACTTTCGGGAGTTCAG	0.478000													67	222					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53191364	53191364	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:53191364C>T	ENST00000566029.1	+	2	1572	c.1363C>T	c.(1363-1365)Cag>Tag	p.Q455*	CHD9_ENST00000564845.1_Nonsense_Mutation_p.Q455*|CHD9_ENST00000447540.1_Nonsense_Mutation_p.Q455*|CHD9_ENST00000398510.3_Nonsense_Mutation_p.Q455*			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	455					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GGCTCAGACTCAGTTGCAAAG	0.418000													7	61					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183967525	183967525	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:183967525G>A	ENST00000402825.3	+	1	43	c.43G>A	c.(43-45)Gag>Aag	p.E15K	ECE2_ENST00000324557.4_Missense_Mutation_p.E15K|EIF2B5_ENST00000444495.1_Intron	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	15	Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGTTACCGGAGCGGAACTG	0.652000											OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	43					0	0	1	0	0
TUBB2A	7280	broad.mit.edu	37	6	3154891	3154891	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:3154891G>A	ENST00000333628.3	-	4	606	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S	TUBB2A_ENST00000489942.1_5'UTR	NM_001069.2	NP_001060.1	Q13885	TBB2A_HUMAN	tubulin, beta 2A class IIa	182					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GCGTTGTAGGGCTCCACCACC	0.557000													21	78					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107824692	107824692	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:107824692G>A	ENST00000379028.3	-	22	2767	c.2297C>T	c.(2296-2298)aCg>aTg	p.T766M	NRCAM_ENST00000379024.4_Missense_Mutation_p.T747M|NRCAM_ENST00000425651.2_Missense_Mutation_p.T766M|NRCAM_ENST00000379022.4_Missense_Mutation_p.T766M|NRCAM_ENST00000351718.4_Missense_Mutation_p.T750M|NRCAM_ENST00000413765.2_Missense_Mutation_p.T747M			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	766	Fibronectin type-III 2.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						CACCTTCCACGTAATCACCAA	0.383000													18	55					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74620313	74620313	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:74620313G>A	ENST00000253159.8	+	14	2527	c.2329G>A	c.(2329-2331)Gca>Aca	p.A777T	ZNF236_ENST00000320610.9_Missense_Mutation_p.A779T	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	777					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GCATCAGCAGGCAGCCTCGAT	0.517000													38	144					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14199968	14199968	+	Missense_Mutation	SNP	G	G	A	rs55819243	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:14199968G>A	ENST00000285021.7	-	9	1629	c.1415C>T	c.(1414-1416)gCt>gTt	p.A472V	XPC_ENST00000449060.2_Missense_Mutation_p.A435V	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	472	Arg/Lys-rich (basic).				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTCTGAGGAGCGGGGGCTTT	0.592000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				11	43					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39822777	39822777	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:39822777G>A	ENST00000216160.6	+	9	1053	c.991G>A	c.(991-993)Gtg>Atg	p.V331M	TAB1_ENST00000331454.3_Missense_Mutation_p.V331M	NM_006116.2	NP_006107.1	Q15750	TAB1_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 1	331	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|urinary_tract(1)	14						CCAGGCCGTCGTGGACCGGGT	0.627000													30	89					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70724105	70724105	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:70724105A>G	ENST00000229195.3	+	6	1004	c.425A>G	c.(424-426)cAc>cGc	p.H142R	CNOT2_ENST00000418359.3_Missense_Mutation_p.H142R|CNOT2_ENST00000548230.1_3'UTR	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	142					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			ATGATGAACCACTCCCAGGTT	0.408000													29	135					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75205426	75205426	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:75205426C>T	ENST00000413679.2	+	14	1782	c.1479C>T	c.(1477-1479)tgC>tgT	p.C493C	SEC14L1_ENST00000436233.4_Silent_p.C493C|SEC14L1_ENST00000392476.2_Silent_p.C493C|SEC14L1_ENST00000591437.1_Silent_p.C459C|SEC14L1_ENST00000585618.1_Silent_p.C493C|SEC14L1_ENST00000431431.2_Silent_p.C459C|SEC14L1_ENST00000430767.4_Silent_p.C493C|SEC14L1_ENST00000443798.4_Silent_p.C493C	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	493	CRAL-TRIO.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						TCTTCCAGTGCGAAGTGCCAG	0.547000													16	43					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32964827	32964827	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:32964827A>G	ENST00000321639.5	+	10	2859	c.2531A>G	c.(2530-2532)cAc>cGc	p.H844R		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	844						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CACTCTCACCACTGGGTGTTC	0.657000													33	111					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349873	65349873	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65349873T>C	ENST00000309295.4	+	9	1995	c.1730T>C	c.(1729-1731)gTa>gCa	p.V577A		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	577	Glu-rich.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ACTGAGGTGGTAGGGTTGGAG	0.567000													21	43					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140938227	140938227	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140938227T>C	ENST00000277549.5	+	21	3433	c.862_splice	c.e21-1	p.S288_splice	CACNA1B_ENST00000371357.1_Splice_Site_p.S1097_splice|CACNA1B_ENST00000277551.2_Splice_Site_p.S1096_splice|CACNA1B_ENST00000371363.1_Splice_Site_p.S1096_splice|CACNA1B_ENST00000371372.1_Splice_Site_p.S1096_splice|CACNA1B_ENST00000545473.1_Splice_Site_p.G122_splice|CACNA1B_ENST00000371355.4_Splice_Site_p.S1097_splice			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1096					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCCTTGTAGGTGGTAACGTGG	0.627000													8	103					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89878383	89878383	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:89878383T>C	ENST00000345097.4	-	2	554	c.438A>G	c.(436-438)gaA>gaG	p.E146E	FOXN3_ENST00000261302.5_Silent_p.E146E|FOXN3_ENST00000557258.1_Silent_p.E146E|FOXN3_ENST00000555353.1_Silent_p.E146E	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	146					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ACGGAAAATGTTCCAAGATCC	0.438000													32	102					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59851885	59851885	+	Silent	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:59851885T>G	ENST00000361421.1	-	3	607	c.387A>C	c.(385-387)acA>acC	p.T129T		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	129						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TAGAAAGCAGTGTTCCATCCT	0.488000													15	136					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133895231	133895231	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:133895231G>A	ENST00000220616.4	+	8	1102	c.1062G>A	c.(1060-1062)gaG>gaA	p.E354E	TG_ENST00000377869.1_Silent_p.E354E	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	354	Thyroglobulin type-1 4.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCAAGGGGAGCCGCCATCTT	0.597000													11	69					0	0	1	0	0
DPF2	5977	broad.mit.edu	37	11	65108004	65108004	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65108004C>A	ENST00000528416.1	+	2	314	c.181C>A	c.(181-183)Cac>Aac	p.H61N	DPF2_ENST00000415073.2_Missense_Mutation_p.H61N|DPF2_ENST00000532264.1_Intron|DPF2_ENST00000252268.4_Missense_Mutation_p.H61N	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	61					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						GGAAAAGCGACACCGGGGTCC	0.557000													24	125					1.64293e-13	1.71518e-13	1	1	0
OPLAH	26873	broad.mit.edu	37	8	145106322	145106322	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145106322C>T	ENST00000426825.1	-	28	3853	c.3772G>A	c.(3772-3774)Gac>Aac	p.D1258N	OPLAH_ENST00000534424.1_5'UTR|CTD-3065J16.6_ENST00000528912.1_RNA	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1258							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGGGCGGGGTCCTCCGGGTCC	0.736000													12	59					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49244666	49244666	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49244666T>A	ENST00000332955.2	-	9	1371	c.824A>T	c.(823-825)gAg>gTg	p.E275V		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	275					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TATGGACGACTCCGTGGTCGC	0.557000													20	75					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75047248	75047248	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:75047248G>T	ENST00000343932.4	+	7	1433	c.1370G>T	c.(1369-1371)cGg>cTg	p.R457L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	457			R -> W (in dbSNP:rs34151816).		alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	GGCAAGCGCCGGTGTATCGGG	0.597000													41	104					1.67305e-13	1.74621e-13	1	1	0
STAB2	55576	broad.mit.edu	37	12	104064492	104064492	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:104064492G>A	ENST00000388887.2	+	22	2482	c.2278G>A	c.(2278-2280)Ggc>Agc	p.G760S		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	760	EGF-like 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TAGCCTCGGCGGCAACGGGAC	0.507000													11	24					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64109474	64109474	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64109474T>C	ENST00000356786.5	+	8	728	c.684T>C	c.(682-684)gcT>gcC	p.A228A	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	228					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGCGGCTGGCTGAACTGCTGC	0.627000													14	51					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140346540	140346540	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140346540C>T	ENST00000289269.5	+	1	721	c.189C>T	c.(187-189)cgC>cgT	p.R63R	PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		63	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGGCTCGCGCGCTGGGGC	0.692000													12	30					0	0	1	0	0
POLD3	10714	broad.mit.edu	37	11	74324006	74324006	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:74324006T>C	ENST00000263681.2	+	5	472	c.343T>C	c.(343-345)Ttc>Ctc	p.F115L	POLD3_ENST00000527458.1_Missense_Mutation_p.F76L|POLD3_ENST00000532497.1_Missense_Mutation_p.F9L	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	115					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					TGGGCCTCTGTTCAATACTGA	0.443000													45	127					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39080605	39080605	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:39080605G>A	ENST00000379907.4	+	14	1500	c.1373G>A	c.(1372-1374)tGt>tAt	p.C458Y	ADAM32_ENST00000437682.2_Missense_Mutation_p.C359Y|ADAM32_ENST00000519315.1_Missense_Mutation_p.C352Y	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	458	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CATCCTGAATGTGACATCGCT	0.328000													8	13					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68113816	68113816	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:68113816T>C	ENST00000262215.3	-	37	5542	c.5153A>G	c.(5152-5154)aAc>aGc	p.N1718S	ARFGEF1_ENST00000517955.1_5'UTR|ARFGEF1_ENST00000520381.1_Missense_Mutation_p.N1172S|ARFGEF1_ENST00000518230.1_Missense_Mutation_p.N556S	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1718					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CTTCAGAAGGTTGGGCTTGGA	0.532000													31	137					0	0	1	0	0
DYRK2	8445	broad.mit.edu	37	12	68051507	68051507	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:68051507C>T	ENST00000344096.3	+	3	1233	c.820C>T	c.(820-822)Cgg>Tgg	p.R274W	DYRK2_ENST00000393555.3_Missense_Mutation_p.R201W	NM_006482.2	NP_006473.2	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	274	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		GGAACACCTGCGGAAGCAGGA	0.522000													26	152					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14488150	14488150	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:14488150G>A	ENST00000344204.4	+	48	7437	c.7413G>A	c.(7411-7413)gaG>gaA	p.E2471E	TRIO_ENST00000537187.1_Intron	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2471					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TCGGCAAGGAGCCCTTCCCCC	0.746000													10	18					0	0	1	0	0
MTERFD3	80298	broad.mit.edu	37	12	107372404	107372404	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:107372404A>G	ENST00000552029.1	-	2	2157	c.89T>C	c.(88-90)tTa>tCa	p.L30S	C12orf23_ENST00000551237.1_3'UTR|MTERFD3_ENST00000240050.4_Missense_Mutation_p.L30S|MTERFD3_ENST00000392830.2_Missense_Mutation_p.L30S			Q49AM1	MTER3_HUMAN	MTERF domain containing 3	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)	7						GAAGCATGCTAAGAAAGGTCT	0.413000													23	77					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106509493	106509493	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:106509493T>C	ENST00000233154.4	+	5	1446	c.1004T>C	c.(1003-1005)gTg>gCg	p.V335A	NCK2_ENST00000522586.1_3'UTR|NCK2_ENST00000393349.2_Missense_Mutation_p.V335A|NCK2_ENST00000451463.2_3'UTR	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	335	SH2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CACTTCAAGGTGCAGCTCGTG	0.572000													9	66					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136501547	136501547	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:136501547A>T	ENST00000393056.2	+	1	66	c.54A>T	c.(52-54)gcA>gcT	p.A18A		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	18					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TGCGGGAGGCAGCCTTCATGT	0.672000													18	68					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75515253	75515253	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75515253T>C	ENST00000355774.2	-	2	1321	c.1106A>G	c.(1105-1107)aAt>aGt	p.N369S	MLH3_ENST00000556740.1_Missense_Mutation_p.N369S|MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000238662.7_Missense_Mutation_p.N369S|MLH3_ENST00000556257.1_Missense_Mutation_p.N369S	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	369					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		ACTAAAACCATTATCTTCACT	0.333000								Mismatch excision repair (MMR)					12	46					0	0	1	0	0
TOR1B	27348	broad.mit.edu	37	9	132566419	132566419	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:132566419G>A	ENST00000259339.2	+	2	327	c.267G>A	c.(265-267)gcG>gcA	p.A89A	TOR1B_ENST00000486372.1_3'UTR	NM_014506.1	NP_055321.1	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B)	89					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)	12		Ovarian(14;0.0586)				TTTTCAAGGCGCTGACTGGCT	0.488000													26	49					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196694375	196694375	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:196694375T>C	ENST00000367429.4	+	12	2061	c.1821T>C	c.(1819-1821)aaT>aaC	p.N607N		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	607	Sushi 10.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TTGGACCTAATTCCGTTCAGT	0.378000													21	89					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401513	77401513	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:77401513T>C	ENST00000282849.5	-	4	1021	c.603A>G	c.(601-603)gtA>gtG	p.V201V	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	201					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTTTGTACAGTACGTGAGGAT	0.527000													22	83					0	0	1	0	0
CHST6	4166	broad.mit.edu	37	16	75512863	75512863	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:75512863G>A	ENST00000332272.4	-	3	1043	c.864C>T	c.(862-864)taC>taT	p.Y288Y	RP11-77K12.4_ENST00000530512.3_RNA|CHST6_ENST00000390664.2_Silent_p.Y288Y	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	288					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CAGTGAAGGCGTAGAGCGCAC	0.657000													20	78					0	0	1	0	0
ABHD16B	140701	broad.mit.edu	37	20	62493306	62493306	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62493306A>G	ENST00000369916.3	+	1	741	c.413A>G	c.(412-414)tAc>tGc	p.Y138C		NM_080622.3	NP_542189.1	Q9H3Z7	ABHGB_HUMAN	abhydrolase domain containing 16B	138							hydrolase activity			endometrium(2)|kidney(1)|lung(3)	6						GTGGAGCGCTACCACGGCCGG	0.716000													15	57					0	0	1	0	0
TBK1	29110	broad.mit.edu	37	12	64891804	64891804	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:64891804A>G	ENST00000331710.5	+	20	2462	c.2123A>G	c.(2122-2124)aAc>aGc	p.N708S		NM_013254.3	NP_037386.1	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	708					I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)	20				GBM - Glioblastoma multiforme(28;0.0386)		GCTGAAAATAACCACATTTTA	0.313000													8	52					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31644179	31644179	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:31644179C>T	ENST00000399332.1	-	4	1029	c.541G>A	c.(541-543)Gat>Aat	p.D181N	HECTD1_ENST00000553700.1_Missense_Mutation_p.D181N	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	181					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AAAGAAGAATCTTGAGGCTCC	0.378000													19	72					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47881313	47881313	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:47881313C>G	ENST00000396105.1	-	5	2337	c.2091G>C	c.(2089-2091)ctG>ctC	p.L697L	ZNFX1_ENST00000371754.4_Silent_p.L697L|ZNFX1_ENST00000371752.1_Silent_p.L697L	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	697							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCTTGTTCCTCAGCTCCCTTA	0.527000													48	156					0	0	1	0	0
YDJC	150223	broad.mit.edu	37	22	21982747	21982747	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:21982747T>G	ENST00000292778.6	-	5	981	c.932A>C	c.(931-933)gAg>gCg	p.E311A	YDJC_ENST00000398873.3_3'UTR	NM_001017964.1	NP_001017964.1	A8MPS7	YDJC_HUMAN	YdjC homolog (bacterial)	311					carbohydrate metabolic process		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds					Colorectal(54;0.105)					CAGAGTGGGCTCACAGGGGAC	0.622000													8	168					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36070601	36070601	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:36070601G>A	ENST00000225893.4	-	5	1477	c.1116C>T	c.(1114-1116)agC>agT	p.S372S	HNF1B_ENST00000427275.2_Silent_p.S346S|HNF1B_ENST00000560016.1_Silent_p.S372S|HNF1B_ENST00000561193.1_Silent_p.S346S	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	372					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TCACCATGGCGCTGTTGCCAT	0.532000													28	70					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95557552	95557552	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:95557552G>A	ENST00000526495.1	-	27	5806	c.5515C>T	c.(5515-5517)Cgg>Tgg	p.R1839W	DICER1_ENST00000556045.1_Missense_Mutation_p.R737W|DICER1_ENST00000343455.3_Missense_Mutation_p.R1839W|DICER1_ENST00000527416.2_5'UTR|DICER1_ENST00000541352.1_Intron|DICER1_ENST00000393063.1_Missense_Mutation_p.R1839W|DICER1_ENST00000527414.1_Missense_Mutation_p.R1839W			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1839					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		ATTAGTGGCCGCATCATGGGA	0.393000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				16	329					0	0	1	0	0
C14orf93	60686	broad.mit.edu	37	14	23456766	23456766	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23456766T>C	ENST00000299088.6	-	7	1704	c.1275A>G	c.(1273-1275)gaA>gaG	p.E425E	RP11-298I3.4_ENST00000556503.1_RNA|RP11-298I3.4_ENST00000557615.1_RNA|C14orf93_ENST00000406429.2_Silent_p.E425E|C14orf93_ENST00000397377.1_Silent_p.E245E|C14orf93_ENST00000397379.3_Silent_p.E425E|C14orf93_ENST00000397382.4_Silent_p.E425E|C14orf93_ENST00000341470.4_Silent_p.E425E|RP11-298I3.4_ENST00000555294.1_RNA	NM_001130708.1|NM_021944.2	NP_001124180.1|NP_068763.2	Q9H972	CN093_HUMAN	chromosome 14 open reading frame 93	425						extracellular region				kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	17	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		CTGACATCAGTTCCTCTGTCA	0.557000													5	70					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50247606	50247606	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50247606C>A	ENST00000246801.3	-	8	1325	c.1243G>T	c.(1243-1245)Ggc>Tgc	p.G415C	TSKS_ENST00000358830.3_Missense_Mutation_p.G215C	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	415							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		TTCAGTGGGCCCAGCCCCTCC	0.592000													21	73					8.10497e-08	8.33977e-08	1	1	0
KIF21A	55605	broad.mit.edu	37	12	39745734	39745734	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:39745734G>T	ENST00000395670.3	-	11	1937	c.1518C>A	c.(1516-1518)aaC>aaA	p.N506K	KIF21A_ENST00000361418.5_Missense_Mutation_p.N506K|KIF21A_ENST00000541463.2_Missense_Mutation_p.N506K|KIF21A_ENST00000544797.2_Missense_Mutation_p.N506K|KIF21A_ENST00000361961.3_Missense_Mutation_p.N506K			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	506					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				CTCTTGTCAAGTTTTTTCGAA	0.353000													30	156					4.4194e-11	4.5893e-11	1	1	0
FNIP1	96459	broad.mit.edu	37	5	131007907	131007907	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:131007907A>T	ENST00000307968.7	-	13	2145	c.2146T>A	c.(2146-2148)Tgt>Agt	p.C716S	FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000307954.8_Missense_Mutation_p.C699S|FNIP1_ENST00000510461.1_Missense_Mutation_p.C744S	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		GCAGCCTCACAAGAAAATGAA	0.453000													43	136					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19861746	19861746	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:19861746T>C	ENST00000225737.6	-	4	615	c.458A>G	c.(457-459)aAa>aGa	p.K153R	AKAP10_ENST00000572155.1_5'UTR|AKAP10_ENST00000395536.3_Missense_Mutation_p.K153R	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	153	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					TAACCAAAATTTCACCAAATG	0.443000													27	81					0	0	1	0	0
CCR2	729230	broad.mit.edu	37	3	46399634	46399634	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:46399634A>G	ENST00000292301.4	+	2	1101	c.616A>G	c.(616-618)Agg>Ggg	p.R206G	CCR2_ENST00000445132.2_Missense_Mutation_p.R206G|CCR2_ENST00000400888.2_Missense_Mutation_p.R206G|CCR2_ENST00000465202.1_3'UTR	NM_001123041.2	NP_001116513.2	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2	206					astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			breast(3)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)	14				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		CACAATAATGAGGAACATTTT	0.458000													88	264					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51259517	51259517	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:51259517G>A	ENST00000245441.5	-	5	538	c.348C>T	c.(346-348)tcC>tcT	p.S116S	NIN_ENST00000486200.1_5'UTR|NIN_ENST00000382043.4_Silent_p.S116S|NIN_ENST00000530997.2_Silent_p.S116S|NIN_ENST00000453196.1_Silent_p.S116S|NIN_ENST00000324330.9_Silent_p.S116S|NIN_ENST00000389868.3_Silent_p.S116S|NIN_ENST00000382041.3_Silent_p.S116S	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	116					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					ACTCCTCCACGGACTCTTGGA	0.547000			T	PDGFRB	MPD								29	77					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175717628	175717628	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:175717628A>G	ENST00000443967.1	+	4	1451	c.1044A>G	c.(1042-1044)ccA>ccG	p.P348P	SIMC1_ENST00000430704.2_Intron|SIMC1_ENST00000341199.6_Intron|SIMC1_ENST00000429602.2_Silent_p.P367P					SUMO-interacting motifs containing 1																		CTCACTTACCAGGAGACAGGC	0.527000													32	487					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54298225	54298225	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:54298225T>C	ENST00000371429.3	-	3	816	c.218A>G	c.(217-219)tAc>tGc	p.Y73C	NDC1_ENST00000540001.1_Missense_Mutation_p.Y73C|NDC1_ENST00000537333.1_5'UTR|NDC1_ENST00000480952.1_5'UTR|NDC1_ENST00000234725.8_5'UTR	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		CAGCAGGAAGTAAAAGATTAC	0.338000													12	34					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914994	46914994	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:46914994G>A	ENST00000307522.3	-	1	1847	c.1074C>T	c.(1072-1074)aaC>aaT	p.N358N		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	358						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTTCCCTCTGGTTATCTGCAG	0.587000													37	281					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242046021	242046021	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:242046021C>T	ENST00000405260.1	-	18	4630	c.3932G>A	c.(3931-3933)gGc>gAc	p.G1311D	PASK_ENST00000234040.4_Missense_Mutation_p.G1311D|PASK_ENST00000358649.4_Missense_Mutation_p.G1318D|PASK_ENST00000544142.1_Missense_Mutation_p.G1125D|PASK_ENST00000539818.1_Missense_Mutation_p.G1095D	NM_001252120.1	NP_001239049.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1311					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		ATGCAAACAGCCTTGGCCATT	0.572000													11	292					0	0	1	0	0
CHAC1	79094	broad.mit.edu	37	15	41247586	41247586	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:41247586G>A	ENST00000446533.3	+	3	718	c.409G>A	c.(409-411)Gtg>Atg	p.V137M	CHAC1_ENST00000487220.1_5'UTR|CHAC1_ENST00000444189.2_Missense_Mutation_p.V137M	NM_001142776.1|NM_024111.3	NP_001136248.1|NP_077016.2	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator homolog 1 (E. coli)	137					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CACTTGGGGCGTGGCATACCA	0.582000													31	81					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100362380	100362380	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:100362380T>C	ENST00000273352.3	+	8	1117	c.849T>C	c.(847-849)agT>agC	p.S283S	GPR128_ENST00000475887.1_Intron	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	283					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						GAGCTAGCAGTTCTCTAGTTT	0.373000													16	46					0	0	1	0	0
FBXO30	84085	broad.mit.edu	37	6	146126460	146126460	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:146126460C>T	ENST00000237281.4	-	2	1248	c.1082G>A	c.(1081-1083)gGt>gAt	p.G361D		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	361							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		TTCACCTTCACCTTCATCATC	0.423000													21	105					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56765257	56765257	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:56765257A>G	ENST00000370754.5	-	3	378	c.379T>C	c.(379-381)Ttt>Ctt	p.F127L				Q03001	DYST_HUMAN	dystonin	0	Actin-binding.|CH 1.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAGTGATAAAATTCTGGCTGG	0.418000													12	353					0	0	1	0	0
HSD3B7	80270	broad.mit.edu	37	16	30999363	30999363	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30999363G>A	ENST00000297679.5	+	7	1062	c.969G>A	c.(967-969)acG>acA	p.T323T	HSD3B7_ENST00000353250.5_3'UTR|HSD3B7_ENST00000262520.6_3'UTR	NM_025193.3	NP_079469.2	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	323					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						ACCCCTACACGCTGGCCGTGG	0.642000													20	60					0	0	1	0	0
NPY	4852	broad.mit.edu	37	7	24324889	24324889	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:24324889C>T	ENST00000407573.1	+	3	320	c.30C>T	c.(28-30)tcC>tcT	p.S10S	NPY_ENST00000242152.2_Silent_p.S10S|NPY_ENST00000405982.1_Silent_p.S10S			P01303	NPY_HUMAN	neuropeptide Y	10					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity			breast(1)|kidney(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	9						TGGGGCTGTCCGGACTGACCC	0.677000													19	84					0	0	1	0	0
NHLRC2	374354	broad.mit.edu	37	10	115668258	115668258	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:115668258G>A	ENST00000369301.3	+	11	2356	c.2144G>A	c.(2143-2145)gGt>gAt	p.G715D		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	715					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		ACACAGCAAGGTTGCATAGCT	0.448000													16	56					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72139141	72139141	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:72139141A>G	ENST00000555818.1	+	9	3254	c.2906A>G	c.(2905-2907)aAc>aGc	p.N969S	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.N969S|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.N969S|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.N444S	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	969	PDZ.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TTCCATGTCAACTATGAGGGC	0.527000													30	73					0	0	1	0	0
NTN1	9423	broad.mit.edu	37	17	9066277	9066277	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:9066277G>A	ENST00000173229.2	+	3	1273	c.1166G>A	c.(1165-1167)cGc>cAc	p.R389H	NTN1_ENST00000538852.1_Missense_Mutation_p.R389H|NTN1_ENST00000546090.1_Missense_Mutation_p.R389H	NM_004822.2	NP_004813.2	O95631	NET1_HUMAN	netrin 1	389	Laminin EGF-like 2.				apoptosis|axon guidance		protein binding		NTN1/ACLY(2)	central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(5)	13						GGCTACTACCGCGACATGGGC	0.662000													9	18					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138968955	138968955	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:138968955A>G	ENST00000288561.8	+	15	3304	c.3055A>G	c.(3055-3057)Agc>Ggc	p.S1019G	UBN2_ENST00000473989.2_Missense_Mutation_p.S1102G	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1102	Ser-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						TGCCCAGGGTAGCCACTCCAG	0.478000													6	174					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42129290	42129290	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:42129290A>G	ENST00000542534.1	+	8	927	c.887A>G	c.(886-888)tAc>tGc	p.Y296C	JMJD7_ENST00000408047.1_Missense_Mutation_p.Y197C|JMJD7-PLA2G4B_ENST00000476036.1_Intron|JMJD7_ENST00000397299.4_Missense_Mutation_p.Y296C|JMJD7-PLA2G4B_ENST00000382448.4_Intron|JMJD7-PLA2G4B_ENST00000342159.4_Intron	NM_001114632.1	NP_001108104.1	P0C869	PA24B_HUMAN		0	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						GACATGGAATACGACCTCAAG	0.552000													14	23					0	0	1	0	0
IGFBP2	3485	broad.mit.edu	37	2	217498647	217498647	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:217498647G>A	ENST00000233809.4	+	1	530	c.401G>A	c.(400-402)cGc>cAc	p.R134H		NM_000597.2	NP_000588.2	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2, 36kDa	134	IGFBP N-terminal.				positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding			endometrium(2)|large_intestine(1)|lung(2)	5		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)		TGTGAGAAGCGCCGGGACGCC	0.682000													4	7					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265091	75265091	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75265091A>G	ENST00000325680.7	+	5	3215	c.3091A>G	c.(3091-3093)Aca>Gca	p.T1031A	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Missense_Mutation_p.T836A	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	836	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AATGGAAGACACACGGGATAA	0.488000													45	131					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83358812	83358812	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:83358812T>C	ENST00000549919.1	+	6	3395	c.1590T>C	c.(1588-1590)ctT>ctC	p.L530L	TMTC2_ENST00000548305.1_Silent_p.L536L|TMTC2_ENST00000321196.3_Silent_p.L536L			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	536						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						GAGGGCTACTTCTCCAGGAGA	0.343000													22	70					0	0	1	0	0
UBA52	7311	broad.mit.edu	37	19	18685871	18685871	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:18685871T>C	ENST00000442744.2	+	5	356	c.298T>C	c.(298-300)Tat>Cat	p.Y100H	UBA52_ENST00000595683.1_Missense_Mutation_p.Y100H|UBA52_ENST00000599595.1_Missense_Mutation_p.Y100H|UBA52_ENST00000597451.1_Missense_Mutation_p.Y100H|UBA52_ENST00000598780.1_Missense_Mutation_p.Y100H|UBA52_ENST00000595158.1_Missense_Mutation_p.Y100H|CRLF1_ENST00000594325.1_Intron|UBA52_ENST00000599551.1_Missense_Mutation_p.Y100H|UBA52_ENST00000596304.1_Missense_Mutation_p.Y100H|UBA52_ENST00000596273.1_Missense_Mutation_p.Y100H|UBA52_ENST00000430157.2_Missense_Mutation_p.Y100H	NM_001033930.1	NP_001029102.1	P62987	RL40_HUMAN	ubiquitin A-52 residue ribosomal protein fusion product 1	100					activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome			endometrium(1)|large_intestine(2)	3						GTGCAGGTGCTATGCTCGCCT	0.582000													12	114					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35484929	35484929	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35484929A>G	ENST00000317538.5	-	4	617	c.453T>C	c.(451-453)ttT>ttC	p.F151F	ZMYM6_ENST00000373333.1_Silent_p.F151F|ZMYM6_ENST00000493328.1_Intron|ZMYM6_ENST00000487874.1_Intron|ZMYM6_ENST00000357182.4_Intron|ZMYM6_ENST00000373340.2_Intron			O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	331					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AGGTAAAGTAAAAAGGGATGT	0.358000													22	80					0	0	1	0	0
EEF1DP3	196549	broad.mit.edu	37	13	32527481	32527481	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:32527481G>A	ENST00000428783.1	+	0	1181																											TGTCGACATCGCAGCTTTCAA	0.488000													12	62					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39872932	39872932	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:39872932C>T	ENST00000502986.2	+	11	1316	c.1074C>T	c.(1072-1074)agC>agT	p.S358S	IDO2_ENST00000343295.4_3'UTR|IDO2_ENST00000389060.4_Silent_p.S345S	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	345					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						AGCTGCGGAGCTATCACATCA	0.542000													4	82					0	0	1	0	0
PPP5C	5536	broad.mit.edu	37	19	46879823	46879823	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:46879823G>A	ENST00000012443.4	+	4	728	c.625G>A	c.(625-627)Gcc>Acc	p.A209T	PPP5C_ENST00000391919.1_Missense_Mutation_p.A103T	NM_006247.3	NP_006238.1	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	209	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			endometrium(4)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|pancreas(1)	18		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		CCGGAAATGTGCCTACCAGGT	0.547000													17	74					0	0	1	0	0
TRAV1-1	28693	broad.mit.edu	37	14	22090072	22090072	+	RNA	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:22090072C>A	ENST00000542354.1	+	0	82																											GGGAGCTTTCCTTCTCTATGT	0.443000													21	59					1.1804e-14	1.23573e-14	1	1	0
GCN1L1	10985	broad.mit.edu	37	12	120585076	120585076	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120585076G>A	ENST00000300648.6	-	38	4739	c.4726_splice	c.e38-1	p.A1576_splice		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1576					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGAGCAATGGCTGCACATCC	0.532000													11	38					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55504242	55504242	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:55504242C>T	ENST00000474267.1	-	6	1542	c.1021G>A	c.(1021-1023)Ggc>Agc	p.G341S	WNT5A_ENST00000264634.4_Missense_Mutation_p.G341S|WNT5A_ENST00000497027.1_Missense_Mutation_p.G326S			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	341					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		TAGCCACGGCCGCAGCACATG	0.627000													22	90					0	0	1	0	0
MRPL50	54534	broad.mit.edu	37	9	104152834	104152834	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:104152834T>C	ENST00000374865.4	-	2	412	c.391A>G	c.(391-393)Aat>Gat	p.N131D	MRPL50_ENST00000539624.1_Intron	NM_019051.2	NP_061924.1	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	131						mitochondrion|ribosome				large_intestine(1)|lung(2)|prostate(2)	5		Acute lymphoblastic leukemia(62;0.0559)				ATAGGGACATTATAGAAATCA	0.413000													35	63					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596693	58596693	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58596693C>T	ENST00000240727.6	-	7	1291	c.892G>A	c.(892-894)Gcg>Acg	p.A298T	ZSCAN18_ENST00000600404.1_Missense_Mutation_p.A354T|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.A298T|ZSCAN18_ENST00000421612.2_Missense_Mutation_p.A162T	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	298					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGCACCCCCGCGGGGGCGGCC	0.736000													13	25					0	0	1	0	0
GM2A	2760	broad.mit.edu	37	5	150646297	150646297	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:150646297T>C	ENST00000357164.3	+	3	574	c.249T>C	c.(247-249)gaT>gaC	p.D83D		NM_000405.4|NM_001167607.1	NP_000396.2|NP_001161079.1	P17900	SAP3_HUMAN	GM2 ganglioside activator	83						lysosome|nucleolus	sphingolipid activator protein activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|upper_aerodigestive_tract(2)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCAGGTGGATTTAGTTTTGG	0.408000													29	66					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145756141	145756141	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145756141T>C	ENST00000276826.5	-	9	3203	c.3002A>G	c.(3001-3003)cAc>cGc	p.H1001R	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.H1032R|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.H1001R			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	1001	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						GGGCAGCGCGTGCACCACGGC	0.692000													5	36					0	0	1	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2983960	2983960	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2983960C>T	ENST00000399667.2	+	6	1856	c.1493C>T	c.(1492-1494)aCg>aTg	p.T498M	FLYWCH1_ENST00000416288.2_Missense_Mutation_p.T497M|FLYWCH1_ENST00000253928.9_Missense_Mutation_p.T498M			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	498						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						CGCCCCAACACGGCGCAGCGG	0.711000													3	4					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555088	44555088	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:44555088A>G	ENST00000330682.2	-	1	1361	c.1126T>C	c.(1126-1128)Tac>Cac	p.Y376H	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	376	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						TCTGTGCGGTACAGCTGATCG	0.572000													40	1427					0	0	1	0	0
FAM227B	196951	broad.mit.edu	37	15	49903433	49903433	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:49903433T>C	ENST00000299338.6	-	3	387	c.84A>G	c.(82-84)gaA>gaG	p.E28E	FAM227B_ENST00000561064.1_Silent_p.E28E|FAM227B_ENST00000558862.1_5'UTR|FAM227B_ENST00000558594.1_Silent_p.E28E|FAM227B_ENST00000560246.1_Silent_p.E28E	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		ACTTTAAGAATTCTTCAATGC	0.279000													4	32					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196388515	196388515	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:196388515C>T	ENST00000328557.4	+	3	2204	c.2001C>T	c.(1999-2001)tgC>tgT	p.C667C		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		TGGTGGCCTGCACTGTCATCG	0.617000													8	237					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33590977	33590977	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:33590977C>G	ENST00000380099.3	+	1	407	c.399C>G	c.(397-399)ttC>ttG	p.F133L	KL_ENST00000426690.2_Intron|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	133	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACAACGTCTTCCGCGACACGG	0.711000													8	46					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102154939	102154939	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:102154939G>A	ENST00000299314.7	-	15	3363	c.3101C>T	c.(3100-3102)gCt>gTt	p.A1034V		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	1034	EF-hand.				cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						AATTCTGGTAGCCAGTGTTCG	0.393000													10	79					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253109	124253109	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:124253109C>T	ENST00000375013.2	-	1	149	c.131G>A	c.(130-132)gGc>gAc	p.G44D		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGTGATCAAGCCAAGGTTGCC	0.418000													54	162					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662682	99662682	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:99662682T>C	ENST00000373034.4	-	1	2589	c.914A>G	c.(913-915)gAc>gGc	p.D305G	PCDH19_ENST00000255531.7_Missense_Mutation_p.D305G|PCDH19_ENST00000420881.2_Missense_Mutation_p.D305G	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	305	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CTCTTCGTAGTCTAAAGCGCC	0.597000													33	31					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63487380	63487380	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:63487380A>G	ENST00000377819.5	+	3	1560	c.1406A>G	c.(1405-1407)aAa>aGa	p.K469R	RTN3_ENST00000341307.2_Intron|RTN3_ENST00000354497.4_Intron|RTN3_ENST00000540798.1_Missense_Mutation_p.K357R|RTN3_ENST00000537981.1_Intron|RTN3_ENST00000356000.3_Intron|RTN3_ENST00000339997.4_Missense_Mutation_p.K450R	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	469					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						GCCACAGTGAAAGTGGTTTTA	0.468000													5	132					0	0	1	0	0
BAG3	9531	broad.mit.edu	37	10	121431897	121431897	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:121431897A>G	ENST00000369085.3	+	3	944	c.638A>G	c.(637-639)gAg>gGg	p.E213G		NM_004281.3	NP_004272.2	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	213					anti-apoptosis|apoptosis|protein folding	cytosol				endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(5)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	20		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		GTGATACACGAGCAGAACGTT	0.652000													46	113					0	0	1	0	0
CDCA7L	55536	broad.mit.edu	37	7	21947818	21947818	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21947818C>T	ENST00000406877.3	-	4	890	c.611G>A	c.(610-612)cGg>cAg	p.R204Q	CDCA7L_ENST00000356195.5_Missense_Mutation_p.R170Q|CDCA7L_ENST00000373934.4_Missense_Mutation_p.R158Q|CDCA7L_ENST00000465490.1_5'UTR	NM_018719.4	NP_061189.2	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like	204					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	29						GCTCTCATCCCGAGAGTCATC	0.463000													17	31					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24390588	24390588	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:24390588T>C	ENST00000330966.7	-	30	3767	c.3605A>G	c.(3604-3606)gAc>gGc	p.D1202G	MYOM3_ENST00000338909.5_Missense_Mutation_p.D92G|MYOM3_ENST00000374434.3_Missense_Mutation_p.D1199G|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1199	Ig-like C2-type 3.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CAATATGGTGTCGTCCTCCCC	0.547000													20	68					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101840547	101840547	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:101840547A>G	ENST00000360264.3	+	15	1909	c.1889A>G	c.(1888-1890)aAc>aGc	p.N630S	CUX1_ENST00000556210.1_Missense_Mutation_p.N517S|CUX1_ENST00000549414.2_Missense_Mutation_p.N619S|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000550008.2_Missense_Mutation_p.N619S|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000546411.2_Missense_Mutation_p.N517S|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000292535.7_Missense_Mutation_p.N619S	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	619					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GATGAGCAGAACATCCTGGCC	0.562000													38	105					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121577312	121577312	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:121577312C>T	ENST00000275159.6	-	16	1852	c.1853G>A	c.(1852-1854)cGt>cAt	p.R618H	TBC1D32_ENST00000398212.2_Missense_Mutation_p.R618H					TBC1 domain family, member 32																		ATATATGTGACGACACACAGA	0.338000													14	51					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187860	152187860	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152187860C>T	ENST00000368801.2	-	3	6320	c.6245G>A	c.(6244-6246)gGc>gAc	p.G2082D	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2082					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCATGTCGGCCATAGCTGGG	0.622000													71	207					0	0	1	0	0
CASP2	835	broad.mit.edu	37	7	143001775	143001775	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:143001775G>A	ENST00000310447.5	+	10	1367	c.1126G>A	c.(1126-1128)Gcc>Acc	p.A376T	CASP2_ENST00000493642.1_3'UTR	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	376					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					AGGGACTGCCGCCATGCGGAA	0.537000													22	109					0	0	1	0	0
ABHD4	63874	broad.mit.edu	37	14	23070609	23070609	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23070609C>T	ENST00000428304.2	+	2	131	c.61C>T	c.(61-63)Cgc>Tgc	p.R21C	ABHD4_ENST00000544562.1_3'UTR	NM_022060.2	NP_071343.2	Q8TB40	ABHD4_HUMAN	abhydrolase domain containing 4	21					lipid catabolic process		hydrolase activity	p.R21C(1)		breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(3)|prostate(1)	14	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)		GCCCACGTGGCGCCCCACTTC	0.542000													29	84					0	0	1	0	0
RAB25	57111	broad.mit.edu	37	1	156039463	156039463	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156039463A>G	ENST00000361084.5	+	4	676	c.433_splice	c.e4-1	p.E145_splice	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	145					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					TCCTGGCAGAAAACAATGGAC	0.408000													133	412					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145096225	145096225	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145096225C>T	ENST00000377470.3	+	4	1501	c.1399C>T	c.(1399-1401)Cgg>Tgg	p.R467W	SPATC1_ENST00000447830.2_Intron	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	467										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAGCGCGTACGGCTCTACGG	0.637000													19	65					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17940942	17940942	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17940942G>T	ENST00000458235.1	-	23	3281	c.3182C>A	c.(3181-3183)cCg>cAg	p.P1061Q	JAK3_ENST00000527670.1_Missense_Mutation_p.P1061Q|JAK3_ENST00000534444.1_Missense_Mutation_p.P1061Q	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	1061	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						AGGAGGCGCCGGCAGCCTCTG	0.682000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								4	11					0.000602214	0.000609374	1	1	0
UBQLN4	56893	broad.mit.edu	37	1	156021624	156021624	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156021624A>C	ENST00000368309.3	-	2	225	c.133T>G	c.(133-135)Ttt>Gtt	p.F45V	UBQLN4_ENST00000368307.1_Missense_Mutation_p.F45V|UBQLN4_ENST00000472638.1_5'UTR	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	45	Ubiquitin-like.					cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					TGAGCCTTAAACCTCCGGGAG	0.547000													19	43					0	0	1	0	0
CHST7	56548	broad.mit.edu	37	X	46434414	46434414	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:46434414G>A	ENST00000276055.3	+	1	1196	c.1048G>A	c.(1048-1050)Gaa>Aaa	p.E350K		NM_019886.2	NP_063939.2	Q9NS84	CHST7_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	350					chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)|endometrium(2)|kidney(1)|lung(2)	8						GGTGATCTGCGAAGCCTGGCT	0.751000													3	7					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160028677	160028677	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:160028677C>A	ENST00000263635.6	+	11	1634	c.1397C>A	c.(1396-1398)cCg>cAg	p.P466Q	TANC1_ENST00000454300.1_Missense_Mutation_p.P360Q	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	466						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TTGCTTTCACCGAGTTCTTCC	0.473000													14	65					9.16793e-09	9.46157e-09	1	1	0
JPH4	84502	broad.mit.edu	37	14	24040173	24040173	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24040173G>A	ENST00000397118.3	-	6	2669	c.1767C>T	c.(1765-1767)ctC>ctT	p.L589L	JPH4_ENST00000544177.1_Silent_p.L254L|JPH4_ENST00000356300.4_Silent_p.L589L	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	589					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CGGGCTCCCCGAGCTCTTCTG	0.667000													12	32					0	0	1	0	0
C3orf14	57415	broad.mit.edu	37	3	62307621	62307621	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:62307621A>G	ENST00000494481.1	+	4	384	c.70A>G	c.(70-72)Atg>Gtg	p.M24V	PTPRG-AS1_ENST00000490916.1_RNA|C3orf14_ENST00000232519.5_Missense_Mutation_p.M24V|C3orf14_ENST00000462069.1_Missense_Mutation_p.M24V|C3orf14_ENST00000542214.1_Missense_Mutation_p.M24V|PTPRG-AS1_ENST00000495542.1_RNA|C3orf14_ENST00000486169.1_3'UTR			Q9HBI5	CC014_HUMAN	chromosome 3 open reading frame 14	24										central_nervous_system(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00023)|KIRC - Kidney renal clear cell carcinoma(15;0.00877)|Kidney(15;0.0101)		ACAAAGATTAATGTTACTTCA	0.299000													12	28					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													5	74					0.184627	0.184914	1	1	0
RASGRF2	5924	broad.mit.edu	37	5	80369244	80369244	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:80369244A>G	ENST00000265080.4	+	5	927	c.860A>G	c.(859-861)gAc>gGc	p.D287G	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	287	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ATCAGCCACGACGACGTCAGC	0.463000													11	74					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764429	110764429	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:110764429C>T	ENST00000451085.1	+	4	2647	c.1601C>T	c.(1600-1602)gCc>gTc	p.A534V	IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.A534V|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000452895.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.A534V	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	534	Fibronectin type-III.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GATATTCAGGCCAATTCAGTT	0.373000													6	36					0	0	1	0	0
FAM220A	84792	broad.mit.edu	37	7	6370604	6370604	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:6370604A>G	ENST00000313324.4	-	2	649	c.182T>C	c.(181-183)tTa>tCa	p.L61S		NM_001037163.1	NP_001032240.1	Q7Z4H9	SIPAR_HUMAN	family with sequence similarity 220, member A	61						nucleus											TTCCAGTGATAATGCCTCACT	0.512000													12	80					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62782126	62782126	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:62782126T>C	ENST00000336232.2	-	2	440	c.305A>G	c.(304-306)aAc>aGc	p.N102S	SLC22A8_ENST00000311438.8_Missense_Mutation_p.N102S|SLC22A8_ENST00000535878.1_Intron|SLC22A8_ENST00000430500.2_Missense_Mutation_p.N102S|SLC22A8_ENST00000545207.1_Missense_Mutation_p.N11S	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	102					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CTTGGTGCTGTTGTAGACCCA	0.602000													78	171					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56565313	56565313	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:56565313A>G	ENST00000323777.3	-	1	432	c.323T>C	c.(322-324)cTc>cCc	p.L108P		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	108						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAAGTGATGGAGCGGCCCATT	0.682000													12	31					0	0	1	0	0
RPS25	6230	broad.mit.edu	37	11	118888739	118888739	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118888739T>C	ENST00000527673.1	-	2	433	c.28A>G	c.(28-30)Aag>Gag	p.K10E	RPS25_ENST00000528547.1_5'UTR	NM_001028.2	NP_001019.1	P62851	RS25_HUMAN	ribosomal protein S25	10					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding			endometrium(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		CCAGCGTCCTTCTTCTTCTTG	0.532000													47	104					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304793	102304793	+	RNA	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:102304793A>C	ENST00000561463.1	+	0	12839																											GCGTGGGAAGAAGAAGACACT	0.592000													3	18					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32200867	32200867	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:32200867G>A	ENST00000400246.1	+	17	1325	c.1183G>A	c.(1183-1185)Gat>Aat	p.D395N	DEPDC5_ENST00000400249.2_Missense_Mutation_p.D395N|DEPDC5_ENST00000536766.1_Missense_Mutation_p.D367N|DEPDC5_ENST00000382105.2_Missense_Mutation_p.D395N|DEPDC5_ENST00000266091.3_Missense_Mutation_p.D395N|DEPDC5_ENST00000535622.1_Missense_Mutation_p.D395N|DEPDC5_ENST00000382112.3_Missense_Mutation_p.D395N|DEPDC5_ENST00000400242.3_Missense_Mutation_p.D395N|DEPDC5_ENST00000400248.1_Missense_Mutation_p.D395N|DEPDC5_ENST00000382111.2_Missense_Mutation_p.D395N			O75140	DEPD5_HUMAN	DEP domain containing 5	395					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TCGTCTGGGCGATGACTATAA	0.453000													53	180					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113711398	113711398	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:113711398C>T	ENST00000550785.1	+	11	1252	c.1083C>T	c.(1081-1083)tcC>tcT	p.S361S	TPCN1_ENST00000541517.1_Silent_p.S361S|TPCN1_ENST00000392569.4_Silent_p.S221S|TPCN1_ENST00000335509.6_Silent_p.S289S	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	289						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						TGATGCCCTCCTACTCCCGGA	0.542000													67	244					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190554370	190554370	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:190554370C>T	ENST00000520309.1	+	3	807	c.719C>T	c.(718-720)gCt>gTt	p.A240V	ANKAR_ENST00000438402.2_Missense_Mutation_p.A240V|ANKAR_ENST00000431575.2_Missense_Mutation_p.A169V|ANKAR_ENST00000281412.6_Missense_Mutation_p.A4V|ANKAR_ENST00000461516.1_3'UTR|ANKAR_ENST00000313581.4_Missense_Mutation_p.A240V	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	240						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ATGAAATATGCTGAAAATATT	0.323000													4	94					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29258406	29258406	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:29258406C>T	ENST00000379558.4	+	17	2653	c.2302C>T	c.(2302-2304)Cgg>Tgg	p.R768W	FAM179A_ENST00000403861.2_Missense_Mutation_p.R713W|FAM179A_ENST00000465300.1_3'UTR	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	768							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GGAGCAGCTACGGGAGCTGAC	0.662000													5	8					0	0	1	0	0
SP3	6670	broad.mit.edu	37	2	174777830	174777830	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:174777830T>C	ENST00000310015.6	-	6	2527	c.1997A>G	c.(1996-1998)gAt>gGt	p.D666G	SP3_ENST00000455789.2_Missense_Mutation_p.D613G|SP3_ENST00000418194.2_Missense_Mutation_p.D598G	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	666					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			CTGTAATTCATCACTTCGAGT	0.393000													15	54					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230001	56230001	+	Nonsense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:56230001T>A	ENST00000279791.1	-	1	876	c.877A>T	c.(877-879)Aag>Tag	p.K293*		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TTTACATCCTTATTTCTCAGA	0.413000													6	88					0	0	1	0	0
TSKU	25987	broad.mit.edu	37	11	76507404	76507404	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:76507404T>C	ENST00000527881.1	+	2	1770	c.744T>C	c.(742-744)agT>agC	p.S248S	TSKU_ENST00000333090.4_Silent_p.S248S			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	248			S -> N (in dbSNP:rs11236938).			extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					TGGCGCCCAGTGGCTTCCGTG	0.652000													15	197					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161324371	161324371	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:161324371C>T	ENST00000428797.2	+	11	1669	c.1314C>T	c.(1312-1314)taC>taT	p.Y438Y	GABRA1_ENST00000444819.1_Silent_p.Y438Y|GABRA1_ENST00000393943.4_Silent_p.Y438Y|GABRA1_ENST00000420560.1_Silent_p.Y438Y|GABRA1_ENST00000023897.6_Silent_p.Y438Y|GABRA1_ENST00000437025.2_Silent_p.Y438Y	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	438					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	ACTTAGTCTACTGGGCTACGT	0.433000													43	133					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134017276	134017276	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:134017276T>A	ENST00000338492.4	+	13	1636	c.1472T>A	c.(1471-1473)aTc>aAc	p.I491N	DPYSL4_ENST00000368629.1_Missense_Mutation_p.I331N|DPYSL4_ENST00000368627.1_Missense_Mutation_p.I331N	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	491					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CTGGCGGAGATCCACGGTGTG	0.716000													22	67					0	0	1	0	0
NTN5	126147	broad.mit.edu	37	19	49167911	49167911	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49167911G>A	ENST00000270235.4	-	3	840	c.745C>T	c.(745-747)Cgg>Tgg	p.R249W	SEC1P_ENST00000430145.2_RNA	NM_145807.1	NP_665806.1	Q8WTR8	NET5_HUMAN	netrin 5	249	Laminin EGF-like 2.					extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	10						TGGCAGTGCCGCCCAGCTGTG	0.662000													8	24					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1154154	1154154	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1154154T>C	ENST00000263741.7	-	5	1023	c.731A>G	c.(730-732)gAc>gGc	p.D244G	SDF4_ENST00000360001.6_Missense_Mutation_p.D244G	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	244	EF-hand 4.				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding	p.D244G(2)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CTCACCCAGGTCCCGGACGAT	0.692000													42	153					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151673725	151673725	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:151673725T>C	ENST00000402676.2	+	4	4439	c.4199T>C	c.(4198-4200)cTa>cCa	p.L1400P	AKAP12_ENST00000359755.5_Missense_Mutation_p.L1295P|AKAP12_ENST00000253332.1_Missense_Mutation_p.L1400P|AKAP12_ENST00000354675.6_Missense_Mutation_p.L1302P	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	1400					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CCTCCCTGCCTAGGTCAAGAG	0.507000													27	90					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720089	179720089	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179720089C>A	ENST00000420890.2	-	19	3162	c.3045G>T	c.(3043-3045)caG>caT	p.Q1015H	CCDC141_ENST00000295723.5_Missense_Mutation_p.Q440H	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	440							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTATCACCTCCTGGAAATGCT	0.363000													25	75					2.12542e-12	2.21375e-12	1	1	0
EPHA3	2042	broad.mit.edu	37	3	89456441	89456441	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:89456441T>C	ENST00000336596.2	+	8	1842	c.1617T>C	c.(1615-1617)agT>agC	p.S539S	EPHA3_ENST00000494014.1_Silent_p.S539S	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	539						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTGGTGAAAGTAGCCAAGTGG	0.398000										TSP Lung(6;0.00050)			7	46					0	0	1	0	0
TRMT1	55621	broad.mit.edu	37	19	13223788	13223788	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:13223788A>G	ENST00000592062.1	-	7	1249	c.679T>C	c.(679-681)Ttt>Ctt	p.F227L	TRMT1_ENST00000221504.8_Missense_Mutation_p.F227L|TRMT1_ENST00000437766.1_Missense_Mutation_p.F227L|TRMT1_ENST00000357720.4_Missense_Mutation_p.F227L			Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)	227							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		ATGACGTCAAACCTCTCCGAC	0.612000													8	35					0	0	1	0	0
NECAB1	64168	broad.mit.edu	37	8	91929728	91929728	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:91929728A>G	ENST00000417640.2	+	6	703	c.366A>G	c.(364-366)caA>caG	p.Q122Q		NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	122					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			AGGACTACCAAGAAGCCTCCA	0.378000													4	72					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25415738	25415738	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:25415738G>A	ENST00000549301.1	+	0	252				SNHG14_ENST00000553149.1_RNA																							GCCAGTGTCCGTCTGCCAGGT	0.622000													8	43					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123880772	123880772	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:123880772A>T	ENST00000373855.1	+	12	1864	c.1604A>T	c.(1603-1605)gAc>gTc	p.D535V	CNTRL_ENST00000238341.5_Missense_Mutation_p.D535V|CNTRL_ENST00000373865.2_3'UTR|CNTRL_ENST00000373850.1_5'UTR			Q7Z7A1	CNTRL_HUMAN	centriolin	535					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GAGATTAAGGACCTGCAAATA	0.388000													24	91					0	0	1	0	0
SAMM50	25813	broad.mit.edu	37	22	44377283	44377283	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:44377283T>C	ENST00000350028.4	+	11	1106	c.949T>C	c.(949-951)Tct>Cct	p.S317P	SAMM50_ENST00000396202.3_Missense_Mutation_p.S107P	NM_015380.4	NP_056195.3	Q9Y512	SAM50_HUMAN	SAMM50 sorting and assembly machinery component	317					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			endometrium(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				TTTTTCAGCGTCTTTCTGGGG	0.418000													15	71					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411831	43411831	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:43411831G>A	ENST00000310826.5	-	3	2557	c.2374C>T	c.(2374-2376)Cgg>Tgg	p.R792W	ZBTB21_ENST00000398511.3_Missense_Mutation_p.R792W|ZBTB21_ENST00000398499.1_Missense_Mutation_p.R792W|ZBTB21_ENST00000398505.3_Missense_Mutation_p.R591W|ZBTB21_ENST00000465968.1_5'UTR	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		ACCTGGTGCCGCCAGATGCTG	0.507000													64	205					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165947362	165947362	+	Silent	SNP	G	G	A	rs138863451	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:165947362G>A	ENST00000360093.3	-	28	5792	c.5301C>T	c.(5299-5301)atC>atT	p.I1767I	SCN3A_ENST00000540861.1_Silent_p.I250I|SCN3A_ENST00000409101.3_Silent_p.I1718I|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000283254.7_Silent_p.I1767I	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1767						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GGATGACCGCGATGTACATGT	0.453000													9	197					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373315	126373315	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:126373315T>C	ENST00000394329.3	+	9	11157	c.11144T>C	c.(11143-11145)cTt>cCt	p.L3715P	FAT4_ENST00000335110.5_Missense_Mutation_p.L2013P	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3715					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGCATCTTACTTCGTCTCGGC	0.468000													7	171					0	0	1	0	0
PNPLA8	50640	broad.mit.edu	37	7	108155015	108155015	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:108155015A>G	ENST00000426128.2	-	2	1046	c.921T>C	c.(919-921)ggT>ggC	p.G307G	PNPLA8_ENST00000436062.1_Silent_p.G307G|PNPLA8_ENST00000483879.1_Intron|PNPLA8_ENST00000257694.8_Silent_p.G307G|PNPLA8_ENST00000453144.1_Silent_p.G207G|PNPLA8_ENST00000388728.5_Silent_p.G307G|PNPLA8_ENST00000422087.1_Silent_p.G307G	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	307					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						GGACAAGTCCACCAATATAAC	0.408000													5	167					0	0	1	0	0
UTP15	84135	broad.mit.edu	37	5	72863173	72863173	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:72863173G>A	ENST00000296792.4	+	2	259	c.4G>A	c.(4-6)Gct>Act	p.A2T	UTP15_ENST00000543251.1_Intron|UTP15_ENST00000508491.1_Missense_Mutation_p.A2T	NM_032175.2	NP_115551.2	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)	2					rRNA processing	cytoplasm|nucleolus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	15		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		TGGAATTATGGCTGGTTATAA	0.348000													29	86					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1652934	1652934	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:1652934G>A	ENST00000252804.4	-	17	2668	c.2618C>T	c.(2617-2619)gCc>gTc	p.A873V		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	873					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CATGCAGCGGGCCCCGCTCCT	0.647000													11	30					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123850804	123850804	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:123850804A>G	ENST00000373855.1	+	3	460	c.200A>G	c.(199-201)gAc>gGc	p.D67G	CNTRL_ENST00000238341.5_Missense_Mutation_p.D67G|CNTRL_ENST00000373865.2_Missense_Mutation_p.D67G			Q7Z7A1	CNTRL_HUMAN	centriolin	67					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						ATGCTTTTGGACTATCAAGAC	0.378000													4	52					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28980935	28980935	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:28980935C>T	ENST00000524189.1	-	28	3465	c.3427G>A	c.(3427-3429)Gcg>Acg	p.A1143T	CTD-2647L4.1_ENST00000523661.1_RNA	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1143					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding	p.A1143T(1)		endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		ACCATCACCGCGTTCCTCTCC	0.542000													81	116					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45501439	45501439	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:45501439T>C	ENST00000359600.5	-	10	2417	c.2212A>G	c.(2212-2214)Acc>Gcc	p.T738A		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	738							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					TTGGCAAAGGTATGCATGGGA	0.498000													14	43					0	0	1	0	0
PLCD3	113026	broad.mit.edu	37	17	43190029	43190029	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43190029C>T	ENST00000322765.5	-	16	2435	c.2322G>A	c.(2320-2322)ctG>ctA	p.L774L	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	775					intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	TGGCTGGTGACAGTGAGGCCC	0.642000													3	20					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39580518	39580518	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39580518G>A	ENST00000225550.3	-	1	257	c.258C>T	c.(256-258)ccC>ccT	p.P86P	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	86	Head.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				CGATGTTGCCGGGAATGTGAC	0.602000													21	80					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155510012	155510012	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155510012A>T	ENST00000302053.3	-	3	375	c.297T>A	c.(295-297)aaT>aaA	p.N99K	FGA_ENST00000403106.3_Missense_Mutation_p.N99K	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	99					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GAGAATCCTTATTGTTCTTCT	0.318000													34	103					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19550199	19550199	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:19550199G>T	ENST00000341998.2	-	7	1476	c.1415C>A	c.(1414-1416)aCg>aAg	p.T472K	SLC24A2_ENST00000286344.3_Missense_Mutation_p.T455K	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	472					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		AATCAGAAACGTGACTTGCTT	0.438000													6	158					0.0215528	0.0216729	1	1	0
UTRN	7402	broad.mit.edu	37	6	144780131	144780131	+	Nonsense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:144780131T>A	ENST00000367545.3	+	19	2510	c.2510T>A	c.(2509-2511)tTg>tAg	p.L837*		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	837	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTGCCAAGCTTGAAGGATTCC	0.458000													4	88					0	0	1	0	0
MTMR10	54893	broad.mit.edu	37	15	31234076	31234076	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:31234076A>G	ENST00000435680.1	-	16	2028	c.1931T>C	c.(1930-1932)gTt>gCt	p.V644A	MTMR10_ENST00000314404.8_Intron|MTMR10_ENST00000425768.1_3'UTR|FAN1_ENST00000362065.4_3'UTR	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	644	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		TGGCAGAATAACACCGTGCAG	0.517000													15	116					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11189816	11189816	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:11189816T>C	ENST00000361445.4	-	40	5769	c.5693A>G	c.(5692-5694)aAc>aGc	p.N1898S	MTOR_ENST00000376838.1_Missense_Mutation_p.N103S	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1898	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CTGGAGGTTGTTGCCTCGTGA	0.507000													7	45					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594902	41594902	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41594902A>G	ENST00000330436.3	+	2	249	c.249A>G	c.(247-249)ggA>ggG	p.G83G		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	83					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	TGCTGTGCGGACATGATGCCG	0.622000													11	100					0	0	1	0	0
TARSL2	123283	broad.mit.edu	37	15	102197157	102197157	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:102197157T>C	ENST00000335968.3	-	18	2444	c.2228A>G	c.(2227-2229)aAt>aGt	p.N743S	TARSL2_ENST00000559492.1_5'UTR	NM_152334.2	NP_689547.2	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	743					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|skin(1)|urinary_tract(1)	29	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGCTGTGCATTTCGTATTTT	0.308000													4	29					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75018993	75018993	+	Silent	SNP	C	C	G	rs143214774	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75018993C>G	ENST00000261978.4	-	6	1682	c.1296G>C	c.(1294-1296)ccG>ccC	p.P432P	LTBP2_ENST00000557425.1_Intron|CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000556690.1_Silent_p.P432P	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	432					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TGTCCGGCTGCGGGATAGGCA	0.672000													28	66					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318628	48318628	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48318628G>A	ENST00000435803.1	+	18	7861	c.7837G>A	c.(7837-7839)Gat>Aat	p.D2613N		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2613					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ATCAAACTCTGATATTTTCAG	0.318000													5	37					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75477005	75477005	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:75477005T>C	ENST00000459803.1	-	0	433					NR_024241.1																						AGGCCTGTGGTACCATGGGAG	0.587000													12	14					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234402104	234402104	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:234402104A>G	ENST00000251722.6	-	25	2998	c.2881T>C	c.(2881-2883)Tgg>Cgg	p.W961R	USP40_ENST00000450966.1_Missense_Mutation_p.W973R|USP40_ENST00000409945.1_Missense_Mutation_p.W137R|USP40_ENST00000427112.2_Missense_Mutation_p.W961R			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	961					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		ACTCTGCCCCAAGACGAAGTA	0.522000													6	27					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31126020	31126020	+	Missense_Mutation	SNP	T	T	C	rs141462042		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:31126020T>C	ENST00000304166.4	+	10	981	c.692T>C	c.(691-693)gTt>gCt	p.V231A	ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.V231A|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.V210A|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.V231A	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	231					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GCCGTCATGGTTTTCTTCCAC	0.562000													13	33					0	0	1	0	0
DBX1	120237	broad.mit.edu	37	11	20178608	20178608	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:20178608G>A	ENST00000524983.2	-	3	935	c.647C>T	c.(646-648)gCc>gTc	p.A216V	DBX1_ENST00000227256.3_Missense_Mutation_p.A216V			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	216					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						GCCCAGCTTGGCCGCCAGCTT	0.642000													7	67					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16534495	16534495	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16534495C>T	ENST00000270747.3	-	3	774	c.638G>A	c.(637-639)cGg>cAg	p.R213Q	ARHGEF19_ENST00000421561.1_Missense_Mutation_p.R213Q	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	213					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.R213Q(1)		cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTGAATTCCGCCCCAGGCG	0.672000													10	42					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4856176	4856176	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:4856176T>C	ENST00000302640.8	+	57	7936	c.7586T>C	c.(7585-7587)gTc>gCc	p.V2529A	AC018816.3_ENST00000449914.1_Intron|ITPR1_ENST00000443694.2_Missense_Mutation_p.V2529A|ITPR1_ENST00000357086.4_Missense_Mutation_p.V2496A|ITPR1_ENST00000354582.6_Missense_Mutation_p.V2529A|AC018816.3_ENST00000489771.1_Intron|ITPR1_ENST00000544951.1_Missense_Mutation_p.V507A|ITPR1_ENST00000463980.1_3'UTR|AC018816.3_ENST00000441894.1_Intron|ITPR1_ENST00000456211.2_Missense_Mutation_p.V2481A|ITPR1_ENST00000423119.2_Missense_Mutation_p.V2496A	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2544	Interaction with ERP44 (By similarity).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ATGTGCATTGTCACTGTGCTG	0.537000													33	78					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091854	74091854	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:74091854G>A	ENST00000443185.2	-	4	2533	c.2216C>T	c.(2215-2217)tCg>tTg	p.S739L	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	739					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ATCCCGCGTCGACCTCGCACT	0.597000													8	42					0	0	1	0	0
YOD1	55432	broad.mit.edu	37	1	207222726	207222726	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:207222726G>A	ENST00000367084.1	-	4	758	c.554C>T	c.(553-555)tCc>tTc	p.S185F	YOD1_ENST00000315927.4_Missense_Mutation_p.S229F|YOD1_ENST00000391927.1_Missense_Mutation_p.S185F	NM_001276320.1	NP_001263249.1	Q5VVQ6	OTU1_HUMAN	YOD1 deubiquitinase	229	OTU.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(3)	11	Prostate(682;0.19)					GTAAAACTTGGACAAAATCGA	0.388000													48	163					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169197209	169197209	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:169197209T>A	ENST00000393743.3	-	15	2393	c.2102A>T	c.(2101-2103)tAt>tTt	p.Y701F		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	701							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AAATCCTAAATACTTAAGGCA	0.363000													21	64					0	0	1	0	0
TBC1D20	128637	broad.mit.edu	37	20	419433	419433	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:419433G>A	ENST00000354200.4	-	8	1156	c.1009C>T	c.(1009-1011)Cct>Tct	p.P337S	TBC1D20_ENST00000461188.1_5'UTR	NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	337					interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				ACCATATCAGGCCTCTGCTGG	0.537000													29	107					0	0	1	0	0
GPM6A	2823	broad.mit.edu	37	4	176594959	176594959	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:176594959C>T	ENST00000280187.7	-	4	304	c.259G>A	c.(259-261)Ggc>Agc	p.G87S	GPM6A_ENST00000393658.2_Missense_Mutation_p.G87S|GPM6A_ENST00000515090.1_Missense_Mutation_p.G80S|GPM6A_ENST00000506894.1_Missense_Mutation_p.G76S	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	87						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GCTGCGATGCCGTAGATCACA	0.398000													6	40					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97833441	97833441	+	Missense_Mutation	SNP	G	G	A	rs142965943		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:97833441G>A	ENST00000297293.5	+	13	4719	c.4426G>A	c.(4426-4428)Gcc>Acc	p.A1476T		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	1476				Missing (in Ref. 2; BAA83031).	early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CATCTCTCCCGCCAACATTGC	0.642000													29	105					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52671835	52671835	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:52671835T>C	ENST00000399231.3	-	18	2438	c.2195A>G	c.(2194-2196)gAg>gGg	p.E732G	MYO5A_ENST00000553916.1_Missense_Mutation_p.E732G|MYO5A_ENST00000356338.6_Missense_Mutation_p.E732G|MYO5A_ENST00000399233.2_Missense_Mutation_p.E732G|MYO5A_ENST00000358212.6_Missense_Mutation_p.E732G	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	732	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TATCAGTTTCTCTAACACATT	0.433000													9	82					0	0	1	0	0
SRI	6717	broad.mit.edu	37	7	87840218	87840218	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:87840218C>T	ENST00000265729.2	-	4	280	c.228G>A	c.(226-228)cgG>cgA	p.R76R	SRI_ENST00000431660.1_Silent_p.R61R|SRI_ENST00000394641.3_Silent_p.R61R|SRI_ENST00000490437.1_Silent_p.R33R|SRI_ENST00000419179.1_Silent_p.R76R	NM_003130.3	NP_003121.1	P30626	SORCN_HUMAN	sorcin	76	EF-hand 2.				heart development|intracellular sequestering of iron ion|muscle organ development|regulation of action potential|regulation of heart contraction|regulation of striated muscle contraction|signal transduction	sarcoplasmic reticulum membrane	calcium channel regulator activity|calcium ion binding|receptor binding			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(14;0.00202)					AAACCATAAGCCGGCAAGTCT	0.284000													4	41					0	0	1	0	0
DNAAF2	55172	broad.mit.edu	37	14	50092539	50092539	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:50092539T>C	ENST00000298292.8	-	3	2315	c.2235A>G	c.(2233-2235)caA>caG	p.Q745Q	DNAAF2_ENST00000406043.3_Silent_p.Q697Q	NM_018139.2	NP_060609.2	Q9NVR5	KTU_HUMAN	dynein, axonemal, assembly factor 2	745					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm				kidney(1)|lung(4)	5						TTGACTCAGGTTGCTGAGATT	0.318000													9	37					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130913672	130913672	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:130913672G>A	ENST00000409031.1	-	14	2490	c.1342C>T	c.(1342-1344)Cgg>Tgg	p.R448W	SMPD4_ENST00000351288.6_Missense_Mutation_p.R419W|SMPD4_ENST00000452225.2_Missense_Mutation_p.R189W|SMPD4_ENST00000431183.2_Missense_Mutation_p.R346W|SMPD4_ENST00000426662.2_Missense_Mutation_p.R84W|SMPD4_ENST00000339679.7_Missense_Mutation_p.R306W|SMPD4_ENST00000443958.2_Missense_Mutation_p.R112W|SMPD4_ENST00000473720.1_5'UTR|SMPD4_ENST00000453750.1_Missense_Mutation_p.R197W	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	409					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GGCGCGTACCGCCACGGCTGC	0.657000													22	56					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8619427	8619427	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:8619427T>C	ENST00000338257.8	-	4	527	c.260A>G	c.(259-261)tAc>tGc	p.Y87C		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	87	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CGTGAGGGCGTAGATGTGCGG	0.612000													7	212					0	0	1	0	0
COG8	84342	broad.mit.edu	37	16	69364834	69364834	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:69364834C>T	ENST00000306875.4	-	5	1861	c.1747G>A	c.(1747-1749)Gcc>Acc	p.A583T		NM_032382.4	NP_115758.3	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	583					protein transport	Golgi membrane|Golgi transport complex				breast(3)|kidney(1)|large_intestine(2)|ovary(2)|skin(1)	9						GGCTCCTCGGCGGGAGGCTCT	0.721000													3	5					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167344	140167344	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140167344T>C	ENST00000504120.2	+	1	1469	c.1469T>C	c.(1468-1470)gTg>gCg	p.V490A	PCDHA1_ENST00000378133.3_Missense_Mutation_p.V490A|PCDHA1_ENST00000394633.3_Missense_Mutation_p.V490A	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCGCTGGTGTCCTATTCG	0.657000													34	137					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327800	85327800	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:85327800C>A	ENST00000299927.3	+	1	1916	c.1894C>A	c.(1894-1896)Ctg>Atg	p.L632M	ZNF592_ENST00000560079.2_Missense_Mutation_p.L632M			Q92610	ZN592_HUMAN	zinc finger protein 592	632					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAAGTGCAGCCTGCTCCGGCA	0.592000													28	81					3.1745e-13	3.31178e-13	1	1	0
NPIPB4	440345	broad.mit.edu	37	16	21854862	21854862	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:21854862A>G	ENST00000415645.2	-	4	429	c.390T>C	c.(388-390)tcT>tcC	p.S130S	NPIPB4_ENST00000451409.1_5'UTR|NPIPB4_ENST00000539318.1_5'UTR|NPIPB4_ENST00000357370.5_Silent_p.S130S					nuclear pore complex interacting protein family, member B4																		CTCGAAAGGAAGAAACTCTTT	0.428000													28	243					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	57026334	57026334	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:57026334T>C	ENST00000251047.5	-	1	860	c.143A>G	c.(142-144)tAc>tGc	p.Y48C		NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	48	L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	GCTGTATTTGTACTCGAAACG	0.692000													5	150					0	0	1	0	0
POU5F1	5460	broad.mit.edu	37	6	31132543	31132543	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31132543T>C	ENST00000513407.1	-	3	1860	c.330A>G	c.(328-330)tcA>tcG	p.S110S	POU5F1_ENST00000259915.8_Silent_p.S306S|POU5F1_ENST00000471529.2_Silent_p.S110S|POU5F1_ENST00000606567.1_Silent_p.S136S|POU5F1_ENST00000441888.3_Silent_p.S110S|POU5F1_ENST00000512818.1_Silent_p.S110S			Q01860	PO5F1_HUMAN	POU class 5 homeobox 1	306					anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	breast(1)|large_intestine(2)|lung(3)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	13						CTGGTCCCCCTGAGAAAGGAG	0.587000			T	EWSR1	sarcoma								4	13					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96024279	96024279	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:96024279C>T	ENST00000297954.4	+	12	3250	c.3250C>T	c.(3250-3252)Ccc>Tcc	p.P1084S	WNK2_ENST00000395477.2_Missense_Mutation_p.P1084S|WNK2_ENST00000427277.2_Missense_Mutation_p.P696S|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.P696S|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1084					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GCAGAGTGTGCCCACCCAGAC	0.687000													4	35					0	0	1	0	0
VPRBP	9730	broad.mit.edu	37	3	51457835	51457835	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:51457835A>G	ENST00000335891.5	-	7	1251	c.1242T>C	c.(1240-1242)ctT>ctC	p.L414L				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	863					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CTGTTTCTCCAAGCCCTTTAG	0.502000													30	71					0	0	1	0	0
NOL11	25926	broad.mit.edu	37	17	65732044	65732044	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:65732044T>C	ENST00000253247.4	+	9	1074	c.959T>C	c.(958-960)aTg>aCg	p.M320T	NOL11_ENST00000535137.1_Missense_Mutation_p.M138T	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	320						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			CATTTGTTTATGCTACATGGA	0.343000													11	43					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91303895	91303895	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:91303895G>A	ENST00000355112.3	+	7	1410	c.1292G>A	c.(1291-1293)aGg>aAg	p.R431K	BLM_ENST00000560509.1_Missense_Mutation_p.R431K	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	431					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TGGAGATACAGGCCTGATTCA	0.403000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				29	154					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85445199	85445199	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:85445199C>T	ENST00000316356.4	-	7	1737	c.1173G>A	c.(1171-1173)tcG>tcA	p.S391S	SYTL2_ENST00000528231.1_Silent_p.S390S|SYTL2_ENST00000527523.1_Silent_p.S342S|SYTL2_ENST00000524452.1_Silent_p.S390S|SYTL2_ENST00000389960.4_Silent_p.S390S			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	390					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GATGAAAAAGCGAAGGCTTTC	0.398000													43	76					0	0	1	0	0
DNAJC5G	285126	broad.mit.edu	37	2	27500629	27500629	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27500629G>A	ENST00000296097.3	+	4	539	c.121G>A	c.(121-123)Gca>Aca	p.A41T	DNAJC5G_ENST00000402462.1_Missense_Mutation_p.A41T|DNAJC5G_ENST00000404433.1_Intron|DNAJC5G_ENST00000406962.1_Intron	NM_173650.1	NP_775921.1	Q8N7S2	DNJ5G_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma	41	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding			cervix(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCCATTCCGCATTGCTTCC	0.498000													37	129					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27529294	27529294	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:27529294A>G	ENST00000396271.3	-	2	261	c.135T>C	c.(133-135)acT>acC	p.T45T	ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375888.1_Silent_p.T43T|ACBD5_ENST00000375901.1_5'UTR|ACBD5_ENST00000375897.3_5'UTR|ACBD5_ENST00000375905.4_Silent_p.T10T	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	43	ACB.				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CCTCAAACCTAGTCTCGTGCA	0.632000													17	81					0	0	1	0	0
REEP3	221035	broad.mit.edu	37	10	65358936	65358936	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:65358936G>C	ENST00000373758.4	+	5	493	c.310G>C	c.(310-312)Gat>Cat	p.D104H	REEP3_ENST00000298249.4_Missense_Mutation_p.D89H	NM_001001330.2	NP_001001330.1	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	104						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCAGGAGATTGATGATTATAT	0.378000													15	48					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123965010	123965010	+	Silent	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:123965010T>A	ENST00000314393.4	+	3	2095	c.1260T>A	c.(1258-1260)cgT>cgA	p.R420R		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	420	Required for interaction with NFYA.|Required for nuclear localization.|Required for repressor activity.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AACCCAAGCGTCCACACATCG	0.622000													21	64					0	0	1	0	0
NTAN1	123803	broad.mit.edu	37	16	15141945	15141945	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:15141945T>C	ENST00000287706.3	-	2	185	c.93A>G	c.(91-93)agA>agG	p.R31R	PDXDC1_ENST00000535621.2_Intron	NM_173474.2	NP_775745.1	Q96AB6	NTAN1_HUMAN	N-terminal asparagine amidase	31						cytoplasm				endometrium(1)|large_intestine(4)|lung(3)	8						CTCTGAGAAGTCTGGCTCTTT	0.433000													8	138					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43340688	43340688	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43340688A>G	ENST00000290650.4	-	13	1519	c.1439_splice	c.e13-1	p.Y481_splice	UBR1_ENST00000382177.2_Splice_Site_p.Y481_splice	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	481					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ATCAGGATATACCTATCGTTT	0.308000													13	22					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10529936	10529936	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:10529936G>A	ENST00000379597.3	+	1	1348	c.792G>A	c.(790-792)acG>acA	p.T264T	GCNT2_ENST00000495262.1_Silent_p.T264T|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000410107.1_Intron			Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	264						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		ACTTTGGCACGGCCTACGTGG	0.473000													4	189					0	0	1	0	0
BBS10	79738	broad.mit.edu	37	12	76741421	76741421	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:76741421G>C	ENST00000393262.3	-	2	427	c.344C>G	c.(343-345)aCc>aGc	p.T115S		NM_024685.3	NP_078961.3	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	115					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)	19						CCTTCCATGGGTTTGAATGTT	0.383000									Bardet-Biedl syndrome				17	82					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95076818	95076818	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:95076818T>C	ENST00000545558.1	-	7	2581	c.2089A>G	c.(2089-2091)Agc>Ggc	p.S697G	NOL8_ENST00000535387.1_Missense_Mutation_p.S697G|NOL8_ENST00000442668.2_Missense_Mutation_p.S697G|NOL8_ENST00000358855.4_Missense_Mutation_p.S629G|NOL8_ENST00000542053.1_Missense_Mutation_p.S629G			Q76FK4	NOL8_HUMAN	nucleolar protein 8	697					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						CTATGGCAGCTGTCTTTGTCA	0.428000													6	24					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13087062	13087062	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:13087062G>A	ENST00000506447.1	+	31	5743	c.5663G>A	c.(5662-5664)gGc>gAc	p.G1888D	CEP192_ENST00000430049.2_Missense_Mutation_p.G1413D|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000325971.8_Missense_Mutation_p.G1292D	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1483										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATTTTGGAAGGCGTTAAAAAA	0.348000													14	63					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580930	140580930	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140580930A>G	ENST00000354757.3	+	1	1583	c.1583A>G	c.(1582-1584)gAc>gGc	p.D528G	PCDHB11_ENST00000536699.1_Missense_Mutation_p.D163G	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		528	Cadherin 5.		D -> E (in dbSNP:rs799834).		calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGGCTTTCGACTTCCGCGTG	0.677000													25	243					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71317818	71317818	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:71317818A>C	ENST00000338099.5	-	3	2342	c.2006T>G	c.(2005-2007)aTc>aGc	p.I669S	FTSJD1_ENST00000434935.2_Missense_Mutation_p.I669S			Q8IYT2	FTSJ1_HUMAN		669						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AACAAAAGTGATGAATCTAAA	0.423000													4	158					0	0	1	0	0
YBEY	54059	broad.mit.edu	37	21	47711253	47711253	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47711253G>C	ENST00000329319.3	+	3	614	c.216G>C	c.(214-216)ctG>ctC	p.L72L	YBEY_ENST00000397692.1_Intron|YBEY_ENST00000397694.1_Silent_p.L27L|YBEY_ENST00000339195.6_Intron|YBEY_ENST00000397701.4_Silent_p.L72L|YBEY_ENST00000397691.1_Silent_p.L72L	NM_058181.1	NP_478061.1	P58557	YBEY_HUMAN	ybeY metallopeptidase (putative)	72							metal ion binding|metalloendopeptidase activity			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)	9						TTTAGCATCTGAAAGCAGGTG	0.408000													12	53					0	0	1	0	0
OMD	4958	broad.mit.edu	37	9	95177629	95177629	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:95177629T>C	ENST00000375550.4	-	3	1346	c.1071A>G	c.(1069-1071)atA>atG	p.I357M	CENPP_ENST00000375587.3_Intron	NM_005014.2	NP_005005.1	Q99983	OMD_HUMAN	osteomodulin	357					cell adhesion	proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|skin(2)	16						AAATAGTGTGTATATGAGGGA	0.353000			T	USP6	aneurysmal bone cysts								4	41					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63206435	63206435	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:63206435C>T	ENST00000263991.5	+	16	3160	c.2678C>T	c.(2677-2679)gCa>gTa	p.A893V	EHBP1_ENST00000431489.1_Missense_Mutation_p.A858V|EHBP1_ENST00000405015.3_Missense_Mutation_p.A858V|EHBP1_ENST00000354487.3_Missense_Mutation_p.A858V|EHBP1_ENST00000496857.1_3'UTR|EHBP1_ENST00000405289.1_Missense_Mutation_p.A858V	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	893						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GAAATGGCTGCAGAAAAGTTG	0.473000													15	56					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69874117	69874117	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:69874117G>A	ENST00000359154.2	+	5	530	c.429G>A	c.(427-429)ggG>ggA	p.G143G	WWP2_ENST00000356003.2_Silent_p.G143G|WWP2_ENST00000569174.1_Silent_p.G143G|WWP2_ENST00000448661.1_Silent_p.G143G|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000542271.1_Silent_p.G27G	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	143					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCTGGACGGGCCAACTGTTG	0.592000													4	133					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113288779	113288779	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:113288779A>T	ENST00000362072.3	-	3	709	c.365T>A	c.(364-366)aTc>aAc	p.I122N	DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000544518.1_Missense_Mutation_p.I121N|DRD2_ENST00000542968.1_Missense_Mutation_p.I122N|DRD2_ENST00000355319.2_Missense_Mutation_p.I122N|DRD2_ENST00000538967.1_Missense_Mutation_p.I122N|DRD2_ENST00000346454.3_Missense_Mutation_p.I122N	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	122					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CAAGTTCAGGATGCTCGCCGT	0.532000													16	61					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89856305	89856305	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:89856305T>C	ENST00000287908.3	+	3	906	c.513T>C	c.(511-513)aaT>aaC	p.N171N	STEAP2_ENST00000394621.2_Silent_p.N171N|STEAP2_ENST00000394626.1_Silent_p.N171N|STEAP2_ENST00000394632.1_Silent_p.N171N|STEAP2_ENST00000394629.2_Silent_p.N171N|STEAP2_ENST00000394622.2_Silent_p.N171N|STEAP2_ENST00000402625.2_Silent_p.N171N	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	171					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					GCAGCAACAATATTCAAGCGC	0.393000													19	94					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158492712	158492712	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:158492712G>A	ENST00000355585.4	+	15	2094	c.2019G>A	c.(2017-2019)caG>caA	p.Q673Q	SYNJ2_ENST00000367121.3_Silent_p.Q673Q|SYNJ2_ENST00000367122.2_Silent_p.Q673Q	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	673							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TCCGCTTCCAGTTCCACAGCA	0.592000													42	87					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160044886	160044886	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:160044886T>C	ENST00000327245.5	-	16	3357	c.2511A>G	c.(2509-2511)ctA>ctG	p.L837L	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	837					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGCAATGCATAGTGTGCGCA	0.418000													21	60					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6368022	6368022	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:6368022G>A	ENST00000262483.8	-	15	2047	c.1960C>T	c.(1960-1962)Cgg>Tgg	p.R654W	ACKR6_ENST00000421306.3_Missense_Mutation_p.R618W|ACKR6_ENST00000576664.1_5'UTR	NM_031220.3	NP_112497.2																					TACATGAACCGCCCCACCAGG	0.617000													17	38					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11979202	11979202	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11979202T>C	ENST00000304030.2	+	3	1518	c.1318T>C	c.(1318-1320)Tgt>Cgt	p.C440R	ZNF439_ENST00000455282.1_Missense_Mutation_p.C304R|ZNF439_ENST00000592534.1_Intron	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						ACCGTATCAATGTAAGGAATG	0.438000													9	74					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923102	35923102	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:35923102T>C	ENST00000490799.1	-	17	2412	c.2059A>G	c.(2059-2061)Aat>Gat	p.N687D	SLC26A8_ENST00000355574.2_Missense_Mutation_p.N687D|SLC26A8_ENST00000394602.2_Missense_Mutation_p.N582D	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	687	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GATGAGTTATTAGGAAGCCAA	0.507000													21	71					0	0	1	0	0
MGAT1	4245	broad.mit.edu	37	5	180219668	180219668	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:180219668C>T	ENST00000446023.2	-	3	1054	c.304G>A	c.(304-306)Gcg>Acg	p.A102T	MGAT1_ENST00000393340.3_Missense_Mutation_p.A102T|MGAT1_ENST00000333055.3_Missense_Mutation_p.A102T|MGAT1_ENST00000427865.2_Missense_Mutation_p.A102T|MGAT1_ENST00000307826.4_Missense_Mutation_p.A102T	NM_001114617.1|NM_001114618.1	NP_001108089.1|NP_001108090.1	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	102					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			endometrium(1)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	13	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCGCCGGCGCGGGGGTCACA	0.706000													4	20					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227230	38227230	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:38227230G>A	ENST00000373048.4	-	3	696	c.697C>T	c.(697-699)Ctg>Ttg	p.L233L	EPHA10_ENST00000319637.6_Silent_p.L233L|EPHA10_ENST00000427468.2_Silent_p.L233L	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	233						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACTTCCACCAGTGTGGAGAAG	0.711000													16	33					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25269070	25269070	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:25269070G>C	ENST00000216962.4	+	15	1888	c.1778G>C	c.(1777-1779)aGa>aCa	p.R593T		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	593					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GGAATCAAGAGAGACCCGGCC	0.602000													35	127					0	0	1	0	0
NUP50	10762	broad.mit.edu	37	22	45574765	45574765	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:45574765C>T	ENST00000347635.3	+	5	1453	c.987C>T	c.(985-987)gaC>gaT	p.D329D	NUP50_ENST00000396096.2_Silent_p.D301D|NUP50_ENST00000407019.2_Silent_p.D301D|NUP50_ENST00000425733.2_Silent_p.D79D	NM_007172.3	NP_009103.2	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa	329	Ser-rich.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CAGAAGGTGACAGTGGTGAAT	0.443000													12	50					0	0	1	0	0
PPIB	5479	broad.mit.edu	37	15	64449054	64449054	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:64449054T>C	ENST00000300026.3	-	4	616	c.398A>G	c.(397-399)tAc>tGc	p.Y133C	SNX22_ENST00000325881.4_3'UTR|PPIB_ENST00000558492.1_5'UTR	NM_000942.4	NP_000933.1	P23284	PPIB_HUMAN	peptidylprolyl isomerase B (cyclophilin B)	133	PPIase cyclophilin-type.				protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			kidney(2)|large_intestine(2)|lung(6)	10					L-Proline(DB00172)	GCCAGGCCCGTAGTGCTTCAG	0.557000													26	88					0	0	1	0	0
SERGEF	26297	broad.mit.edu	37	11	18010233	18010233	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18010233G>T	ENST00000265965.5	-	8	906	c.755C>A	c.(754-756)cCt>cAt	p.P252H	SERGEF_ENST00000528200.1_Missense_Mutation_p.P252H|SERGEF_ENST00000532265.1_Missense_Mutation_p.P138H	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	252					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						CTGGGGCACAGGAAGGAAAGC	0.473000													20	56					8.10497e-08	8.33977e-08	1	1	0
TTC4	7268	broad.mit.edu	37	1	55203289	55203289	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:55203289A>G	ENST00000371281.3	+	9	1100	c.1013A>G	c.(1012-1014)tAc>tGc	p.Y338C	TTC4_ENST00000371284.5_3'UTR|MROH7_ENST00000414150.2_3'UTR	NM_004623.4	NP_004614.3	O95801	TTC4_HUMAN	tetratricopeptide repeat domain 4	338							binding			breast(2)|endometrium(3)|kidney(1)|lung(2)|stomach(1)	9						GCAGAACTATACCGGGTGCCT	0.507000													4	27					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51696750	51696750	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:51696750A>G	ENST00000335449.6	+	10	1511	c.1455A>G	c.(1453-1455)acA>acG	p.T485T	GLDN_ENST00000396399.2_Silent_p.T361T	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	485	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		TCTATGTCACAGACACCAAAG	0.453000													29	124					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332389	71332389	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:71332389T>C	ENST00000242462.4	-	2	440	c.411A>G	c.(409-411)caA>caG	p.Q137Q		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	137					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						TGCGCAGCGTTTGAGTCAGCG	0.692000													19	62					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073690	134073690	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:134073690C>T	ENST00000264360.4	+	1	3221	c.2395C>T	c.(2395-2397)Ccg>Tcg	p.P799S		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	799					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACCCAGTAACCCGGCCCAGGT	0.602000													3	39					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51585438	51585438	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:51585438C>T	ENST00000389243.4	-	10	1440	c.501G>A	c.(499-501)caG>caA	p.Q167Q	POU6F1_ENST00000550824.1_Silent_p.Q167Q|POU6F1_ENST00000333640.10_Silent_p.Q167Q			Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	167	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	11						CCTGACCCACCTGGGTCTGTG	0.572000													27	141					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958826	53958826	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53958826G>A	ENST00000454407.1	+	0	1518							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.418000													9	279					0	0	1	0	0
CPSF2	53981	broad.mit.edu	37	14	92600662	92600662	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:92600662A>G	ENST00000298875.4	+	5	663	c.378A>G	c.(376-378)atA>atG	p.I126M		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	126					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TTGATAAAATACAGCAGCTAA	0.323000													3	25					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52566593	52566593	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:52566593T>C	ENST00000395489.2	-	15	2056	c.1660A>G	c.(1660-1662)Aag>Gag	p.K554E	A1CF_ENST00000373997.3_Missense_Mutation_p.K553E|A1CF_ENST00000374001.1_Missense_Mutation_p.K553E|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000282641.2_Missense_Mutation_p.K561E|A1CF_ENST00000395495.1_Missense_Mutation_p.K506E|A1CF_ENST00000373993.1_Missense_Mutation_p.K561E|A1CF_ENST00000373995.3_Missense_Mutation_p.K561E	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	561					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ACCGCTTGCTTGAGCTGGGCT	0.498000													33	95					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186944294	186944294	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:186944294C>T	ENST00000337774.5	-	12	1845	c.1456G>A	c.(1456-1458)Gtg>Atg	p.V486M		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	486	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GCGGCGGTCACGATCCAGCTG	0.567000													3	14					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1741947	1741947	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:1741947C>T	ENST00000397196.2	+	3	436	c.204C>T	c.(202-204)caC>caT	p.H68H	WNT5B_ENST00000310594.3_Silent_p.H68H|WNT5B_ENST00000537031.1_Silent_p.H68H|WNT5B_ENST00000542408.1_Silent_p.H68H	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	68					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			ACCAGGAGCACATGGCCTACA	0.602000													35	168					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130925042	130925042	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:130925042T>C	ENST00000409031.1	-	9	2046	c.898A>G	c.(898-900)Act>Gct	p.T300A	SMPD4_ENST00000351288.6_Missense_Mutation_p.T300A|SMPD4_ENST00000452225.2_Silent_p.K13K|SMPD4_ENST00000431183.2_Missense_Mutation_p.T227A|SMPD4_ENST00000426662.2_Silent_p.K13K|SMPD4_ENST00000339679.7_Missense_Mutation_p.T187A|SMPD4_ENST00000443958.2_5'UTR|SMPD4_ENST00000473720.1_5'UTR|SMPD4_ENST00000453750.1_Intron	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	261					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	TGGAGCAGAGTTTCTGACCTC	0.552000													23	72					0	0	1	0	0
MEF2C	4208	broad.mit.edu	37	5	88100458	88100458	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:88100458T>C	ENST00000504921.2	-	3	887	c.215A>G	c.(214-216)tAc>tGc	p.Y72C	MEF2C_ENST00000539796.1_Missense_Mutation_p.Y72C|MEF2C_ENST00000506554.1_Missense_Mutation_p.Y72C|MEF2C_ENST00000340208.5_Missense_Mutation_p.Y72C|MEF2C_ENST00000508569.1_Missense_Mutation_p.Y72C|MEF2C_ENST00000514015.1_Missense_Mutation_p.Y72C|MEF2C_ENST00000514028.1_Missense_Mutation_p.Y72C|MEF2C_ENST00000510942.1_Missense_Mutation_p.Y72C|MEF2C_ENST00000437473.2_Missense_Mutation_p.Y72C|MEF2C_ENST00000424173.2_Missense_Mutation_p.Y72C			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	72					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CGGCTCGTTGTACTCCGTGTA	0.547000										HNSCC(66;0.2)			15	48					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19284283	19284283	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:19284283A>G	ENST00000308406.5	+	4	1147	c.761A>G	c.(760-762)gAg>gGg	p.E254G	MAPK7_ENST00000395602.4_Missense_Mutation_p.E254G|MAPK7_ENST00000299612.7_Missense_Mutation_p.E115G|MAPK7_ENST00000395604.3_Missense_Mutation_p.E254G|MAPK7_ENST00000571657.1_Intron	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	254	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					ATCTTTGGTGAGATGCTGGCC	0.562000													13	43					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53303779	53303779	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53303779T>G	ENST00000438150.2	-	2	2053	c.1160A>C	c.(1159-1161)aAg>aCg	p.K387T	ZNF28_ENST00000457749.2_Missense_Mutation_p.K440T|ZNF28_ENST00000360272.4_Missense_Mutation_p.K387T|ZNF28_ENST00000414252.2_Missense_Mutation_p.K387T			P17035	ZNF28_HUMAN	zinc finger protein 28	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TTCATTACACTTGTAAGGCTT	0.373000													13	160					0	0	1	0	0
FRS3	10817	broad.mit.edu	37	6	41738916	41738916	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:41738916G>A	ENST00000373018.3	-	7	1171	c.920C>T	c.(919-921)cCg>cTg	p.P307L	FRS3_ENST00000259748.2_Missense_Mutation_p.P307L	NM_006653.3	NP_006644.1	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	307					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ATTCCAGCCCGGCTCCTCTGG	0.687000													22	40					0	0	1	0	0
CDKN2C	1031	broad.mit.edu	37	1	51439640	51439640	+	Missense_Mutation	SNP	A	A	G	rs139629762		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:51439640A>G	ENST00000262662.1	+	4	2239	c.205A>G	c.(205-207)Act>Gct	p.T69A	CDKN2C_ENST00000396148.1_Missense_Mutation_p.T69A|CDKN2C_ENST00000371761.3_Missense_Mutation_p.T69A			P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	69					cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(11)|p.?(1)		central_nervous_system(8)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|thyroid(1)	23				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		GAAAGACCGAACTGGTTTCGC	0.443000			D		"""glioma, MM"""								24	52					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47635647	47635647	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:47635647G>A	ENST00000406134.1	+	2	381	c.319G>A	c.(319-321)Gct>Act	p.A107T	MSH2_ENST00000543555.1_Missense_Mutation_p.A41T|MSH2_ENST00000233146.2_Missense_Mutation_p.A107T			P43246	MSH2_HUMAN	mutS homolog 2	107					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TAAGAATAGAGCTGGAAATAA	0.289000			"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian"""	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				24	59					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33565125	33565125	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:33565125G>A	ENST00000321505.4	+	1	1305	c.1125G>A	c.(1123-1125)tcG>tcA	p.S375S	KIAA1549L_ENST00000265654.5_Silent_p.S375S|KIAA1549L_ENST00000389726.3_Silent_p.S375S					KIAA1549-like																		TGAGAGCATCGCCCTCCTCCA	0.483000											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	50					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52684237	52684237	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:52684237T>C	ENST00000399231.3	-	12	1675	c.1432A>G	c.(1432-1434)Atg>Gtg	p.M478V	MYO5A_ENST00000553916.1_Missense_Mutation_p.M478V|MYO5A_ENST00000356338.6_Missense_Mutation_p.M478V|MYO5A_ENST00000399233.2_Missense_Mutation_p.M478V|MYO5A_ENST00000358212.6_Missense_Mutation_p.M478V	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	478	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TGTTCCTTCATATATTCTTCT	0.313000													6	32					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12197792	12197792	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:12197792T>C	ENST00000379033.3	+	6	559	c.412T>C	c.(412-414)Ttg>Ctg	p.L138L	SEC61A2_ENST00000298428.9_Silent_p.L160L|SEC61A2_ENST00000304267.8_Silent_p.L160L|SEC61A2_ENST00000379020.4_Silent_p.L160L|SEC61A2_ENST00000495368.1_3'UTR	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	160						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				TGTTGCTGGTTTGATTGTGCT	0.468000													55	445					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22183543	22183543	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22183543G>A	ENST00000374695.3	-	44	5619	c.5540C>T	c.(5539-5541)gCc>gTc	p.A1847V		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1847	Ig-like C2-type 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTGGTCCATGGCAAACATGTT	0.562000													6	170					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42440146	42440146	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:42440146A>G	ENST00000379310.3	-	11	1307	c.1239T>C	c.(1237-1239)agT>agC	p.S413S	VWA8_ENST00000281496.6_Silent_p.S413S	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		CACAAGGTTGACTTAATAGCC	0.443000													7	120					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63981379	63981379	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:63981379A>G	ENST00000398590.3	+	12	2434	c.1881A>G	c.(1879-1881)gcA>gcG	p.A627A	ATXN7_ENST00000295900.6_Silent_p.A627A|ATXN7_ENST00000487717.1_Silent_p.A627A|ATXN7_ENST00000484332.1_Silent_p.A482A|ATXN7_ENST00000538065.1_Silent_p.A627A	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	627					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CACTAAATGCACAGCCTGCTG	0.547000													49	143					0	0	1	0	0
BLVRA	644	broad.mit.edu	37	7	43827605	43827605	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:43827605C>T	ENST00000402924.1	+	4	278	c.115C>T	c.(115-117)Ctg>Ttg	p.L39L	BLVRA_ENST00000265523.4_Silent_p.L39L	NM_001253823.1	NP_001240752.1	P53004	BIEA_HUMAN	biliverdin reductase A	39					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			endometrium(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(2)	12					NADH(DB00157)	GTTCCTGAACCTGATTGGCTT	0.552000													43	138					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10220380	10220380	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10220380A>G	ENST00000428358.1	+	6	759	c.587A>G	c.(586-588)cAc>cGc	p.H196R	PPAN_ENST00000393793.1_Missense_Mutation_p.H143R|PPAN_ENST00000556468.1_Missense_Mutation_p.H196R|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.H196R|PPAN_ENST00000253107.7_Missense_Mutation_p.H196R	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		196	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GACTTCCGCCACTAGTGAGTG	0.607000													52	204					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24524815	24524815	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24524815G>T	ENST00000342740.5	+	9	823	c.669G>T	c.(667-669)aaG>aaT	p.K223N	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	223										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		TCTACTGCAAGGACTTGCGGC	0.597000													37	116					7.04047e-22	7.4361e-22	1	1	0
OR2H2	7932	broad.mit.edu	37	6	29556088	29556088	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:29556088G>A	ENST00000383640.2	+	1	406	c.367G>A	c.(367-369)Gct>Act	p.A123T	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	123					defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						TCGCTACGTGGCTGTCTGCCA	0.577000													33	105					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199073	118199073	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:118199073C>T	ENST00000425217.1	-	4	696	c.642G>A	c.(640-642)tcG>tcA	p.S214S	KSR2_ENST00000339824.5_Silent_p.S243S	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	243	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AACGGTGGCCCGACTCCAGTG	0.751000													39	80					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6612992	6612992	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:6612992C>T	ENST00000285599.3	+	15	2586	c.2550C>T	c.(2548-2550)ttC>ttT	p.F850F	MAN2B2_ENST00000504248.1_Silent_p.F799F	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	850					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						TGGTGCTGTTCGGAGACCTCG	0.657000													9	42					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886446	57886446	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:57886446G>T	ENST00000302610.1	-	1	470	c.471C>A	c.(469-471)atC>atA	p.I157I	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				TGGTACGCAGGATGGCTCCTG	0.552000													7	73					0.000157383	0.00015972	1	1	0
ACBD4	79777	broad.mit.edu	37	17	43220866	43220866	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43220866G>A	ENST00000431281.1	+	12	1353	c.884G>A	c.(883-885)cGc>cAc	p.R295H	ACBD4_ENST00000592162.1_Missense_Mutation_p.A236T|ACBD4_ENST00000591859.1_Missense_Mutation_p.R295H|ACBD4_ENST00000398322.3_Silent_p.A282A|ACBD4_ENST00000586346.1_Missense_Mutation_p.R295H|ACBD4_ENST00000321854.8_Silent_p.A282A	NM_001135704.1	NP_001129176.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	0							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						CGGGGCCCGCGCTGCTCTTCT	0.657000													20	53					0	0	1	0	0
GFI1	2672	broad.mit.edu	37	1	92946223	92946223	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:92946223A>G	ENST00000370332.1	-	4	1039	c.721T>C	c.(721-723)Tcg>Ccg	p.S241P	GFI1_ENST00000427103.1_Missense_Mutation_p.S241P|GFI1_ENST00000294702.5_Missense_Mutation_p.S241P	NM_001127215.1	NP_001120687.1	Q99684	GFI1_HUMAN	growth factor independent 1 transcription repressor	241					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		AGCAGCTCCGACTCCACCTTG	0.692000													3	11					0	0	1	0	0
UTP23	84294	broad.mit.edu	37	8	117861266	117861266	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:117861266A>G	ENST00000520733.1	+	2	317	c.185A>G	c.(184-186)cAt>cGt	p.H62R	UTP23_ENST00000517820.1_3'UTR|RAD21_ENST00000297338.2_Silent_p.D541D|RAD21_ENST00000523986.1_Silent_p.D45D|RAD21_ENST00000517749.1_5'UTR|RAD21_ENST00000518055.1_Silent_p.D86D			Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component, homolog (yeast)	0					rRNA processing	nucleolus				breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	12						ATGCATCTTCATCCTGAATAA	0.408000													40	168					0	0	1	0	0
FBXO25	26260	broad.mit.edu	37	8	363094	363094	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:363094T>C	ENST00000276326.5	+	2	134	c.15T>C	c.(13-15)ggT>ggC	p.G5G	FBXO25_ENST00000352684.2_5'UTR|FBXO25_ENST00000350302.3_Silent_p.G5G|FBXO25_ENST00000382824.1_5'UTR	NM_183421.1	NP_904357.1	Q8TCJ0	FBX25_HUMAN	F-box protein 25	5	Interaction with beta-actin.					nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		CATTTTTGGGTCAGGACTGGA	0.318000													20	92					0	0	1	0	0
CHRAC1	54108	broad.mit.edu	37	8	141525311	141525311	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:141525311G>C	ENST00000220913.5	+	3	563	c.361G>C	c.(361-363)Gat>Cat	p.D121H	CHRAC1_ENST00000519533.1_3'UTR	NM_017444.5	NP_059140.1	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1	121					chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(2)	2	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			GAATGACAATGATAATGAAAG	0.383000													42	91					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63904622	63904622	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:63904622C>T	ENST00000443617.2	-	77	14315	c.14228G>A	c.(14227-14229)cGg>cAg	p.R4743Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4743	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CTCACGGTACCGCACCACTTT	0.552000													12	85					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28890060	28890060	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:28890060G>A	ENST00000395503.4	+	1	252	c.68G>A	c.(67-69)gGc>gAc	p.G23D	ATP2A1_ENST00000357084.3_Missense_Mutation_p.G23D	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	23					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GAGACCACGGGCCTCACCCCG	0.582000													8	30					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186761056	186761056	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:186761056T>C	ENST00000169298.3	+	4	1239	c.565T>C	c.(565-567)Tca>Cca	p.S189P	ST6GAL1_ENST00000448044.1_Missense_Mutation_p.S189P|ST6GAL1_ENST00000457772.2_Intron	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	189					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		TGTTGTGTCGTCAGCGGGATC	0.522000													33	142					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12662375	12662375	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:12662375G>A	ENST00000566228.1	+	21	2400	c.2331G>A	c.(2329-2331)ccG>ccA	p.P777P	CTD-3037G24.3_ENST00000564505.1_RNA|SNX29_ENST00000306030.3_Silent_p.P392P	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	392					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						ACATCACCCCGCCCGGAGAGC	0.637000													25	62					0	0	1	0	0
SLC41A3	54946	broad.mit.edu	37	3	125741708	125741708	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:125741708C>T	ENST00000383598.2	-	5	873	c.588G>A	c.(586-588)acG>acA	p.T196T	SLC41A3_ENST00000508835.1_Silent_p.T105T|SLC41A3_ENST00000360370.4_Silent_p.T222T|SLC41A3_ENST00000346785.5_Silent_p.T186T|SLC41A3_ENST00000315891.6_Silent_p.T222T	NM_001008487.1	NP_001008487.1	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3	222						integral to membrane|plasma membrane	cation transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(6)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18				GBM - Glioblastoma multiforme(114;0.167)		CTGCAATGGGCGTGGCAATGT	0.507000													74	188					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119594436	119594436	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:119594436C>T	ENST00000267260.4	+	13	2057	c.1669C>T	c.(1669-1671)Cgg>Tgg	p.R557W		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	557	Arg-rich.|Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						gagtcggagccggagccggag	0.731000													10	16					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31435825	31435825	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:31435825C>T	ENST00000389202.2	+	29	3348	c.3299C>T	c.(3298-3300)gCc>gTc	p.A1100V		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	1100					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GTCTACAATGCCATTCCCATC	0.512000													27	85					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197896780	197896780	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:197896780C>T	ENST00000367390.3	+	5	793	c.766C>T	c.(766-768)Cag>Tag	p.Q256*	LHX9_ENST00000367391.1_Nonsense_Mutation_p.Q256*|LHX9_ENST00000337020.2_Nonsense_Mutation_p.Q265*|LHX9_ENST00000561173.1_Nonsense_Mutation_p.Q271*|LHX9_ENST00000367387.4_Nonsense_Mutation_p.Q265*	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	265					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						TCCACCCTCGCAGAAGACCAA	0.512000													7	402					0	0	1	0	0
CANX	821	broad.mit.edu	37	5	179132782	179132782	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:179132782G>A	ENST00000247461.4	+	2	300	c.100G>A	c.(100-102)Gac>Aac	p.D34N	CANX_ENST00000415618.2_Missense_Mutation_p.D69N|CANX_ENST00000452673.2_Missense_Mutation_p.D34N|CANX_ENST00000512607.2_5'UTR|CANX_ENST00000504734.1_Missense_Mutation_p.D34N	NM_001746.3	NP_001737.1	P27824	CALX_HUMAN	calnexin	34					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|prostate(2)|urinary_tract(3)	22	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	tattgaggatgaccttgacga	0.428000													77	245					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35720085	35720085	+	Missense_Mutation	SNP	T	T	C	rs144393265	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35720085T>C	ENST00000314888.9	-	13	1768	c.1415A>G	c.(1414-1416)cAg>cGg	p.Q472R	TLN1_ENST00000540444.1_Missense_Mutation_p.Q472R	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	472					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AATCTGCTGCTGGGCAGGGGG	0.627000													27	68					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128838881	128838881	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:128838881G>A	ENST00000310343.9	-	22	6184	c.6185C>T	c.(6184-6186)gCt>gTt	p.A2062V	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.A1713V|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.A1713V	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	2062	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CAACGCTGTAGCATAGGTCCT	0.592000													3	24					0	0	1	0	0
PRNP	5621	broad.mit.edu	37	20	4680489	4680489	+	Missense_Mutation	SNP	G	G	A	rs74315412		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:4680489G>A	ENST00000379440.4	+	2	910	c.623G>A	c.(622-624)cGc>cAc	p.R208H	PRNP_ENST00000430350.2_Missense_Mutation_p.R208H	NM_000311.3|NM_001080121.1|NM_001080122.1|NM_001080123.1|NM_001271561.1|NM_183079.2	NP_000302.1|NP_001073590.1|NP_001073591.1|NP_001073592.1|NP_001258490.1|NP_898902.1	P04156	PRIO_HUMAN	prion protein	208	Interaction with GRB2, ERI3 and SYN1 (By similarity).		R -> H (in CJD).		axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	14					Tetracycline(DB00759)	ATGATGGAGCGCGTGGTTGAG	0.527000													13	64					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70071052	70071052	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:70071052T>C	ENST00000370598.1	+	29	4708	c.3887T>C	c.(3886-3888)aTa>aCa	p.I1296T	BAI3_ENST00000238918.8_Missense_Mutation_p.I502T|BAI3_ENST00000546190.1_Missense_Mutation_p.I260T	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1296					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GACATGGACATAGTCCATCCT	0.368000													13	54					0	0	1	0	0
DDX21	9188	broad.mit.edu	37	10	70719971	70719971	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:70719971C>T	ENST00000354185.4	+	2	595	c.497C>T	c.(496-498)gCt>gTt	p.A166V		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	166						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CCCAGTGAAGCTGCCAGTGAA	0.393000													8	97					0	0	1	0	0
GAS7	8522	broad.mit.edu	37	17	10101649	10101649	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10101649C>T	ENST00000432992.2	-	1	219	c.59G>A	c.(58-60)gGg>gAg	p.G20E	GAS7_ENST00000540214.1_5'UTR	NM_201433.1	NP_958839.1	O60861	GAS7_HUMAN	growth arrest-specific 7	20	SH3.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(7)|lung(18)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	39						GAAGCGCAGCCCCTGGCCGTG	0.736000			T	MLL	AML*								5	43					0	0	1	0	0
APITD1	378708	broad.mit.edu	37	1	10500429	10500429	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:10500429A>G	ENST00000602787.1	+	4	651	c.235A>G	c.(235-237)Act>Gct	p.T79A	APITD1_ENST00000462462.1_3'UTR|APITD1-CORT_ENST00000465026.1_3'UTR|APITD1-CORT_ENST00000400900.2_Missense_Mutation_p.T79A|APITD1-CORT_ENST00000470413.2_Intron|APITD1_ENST00000309048.3_Missense_Mutation_p.T79A|APITD1_ENST00000602296.1_Intron	NM_198544.3	NP_940946.1			apoptosis-inducing, TAF9-like domain 1											kidney(1)|lung(1)|ovary(1)|stomach(1)	4	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		CACAATTAACACTGAAGATGT	0.403000													10	33					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121986850	121986850	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:121986850C>T	ENST00000377069.4	-	6	928	c.522G>A	c.(520-522)caG>caA	p.Q174Q	KDM2B_ENST00000536437.1_Silent_p.Q88Q|KDM2B_ENST00000538046.2_Silent_p.Q205Q|KDM2B_ENST00000377071.4_Silent_p.Q205Q	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	205					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding	p.Q205Q(1)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CCTTCAGATGCTGGGGCCACA	0.552000													13	134					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140282029	140282029	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:140282029C>T	ENST00000458420.3	+	15	2656	c.2466C>T	c.(2464-2466)agC>agT	p.S822S		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	822					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CCCGGAGTAGCATCCAGCACA	0.502000										HNSCC(16;0.037)			17	102					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678331	25678331	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:25678331T>A	ENST00000382051.3	+	13	2083	c.2033T>A	c.(2032-2034)gTc>gAc	p.V678D	SLC34A2_ENST00000504570.1_Missense_Mutation_p.V677D|SLC34A2_ENST00000503434.1_Missense_Mutation_p.V677D	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	678					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				CAGGGTGAGGTCCCTGCCTCG	0.582000			T	ROS1	NSCLC								13	62					0	0	1	0	0
FAM216B	144809	broad.mit.edu	37	13	43358251	43358251	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:43358251A>T	ENST00000537894.1	+	2	171	c.48A>T	c.(46-48)caA>caT	p.Q16H	FAM216B_ENST00000313851.1_Missense_Mutation_p.Q16H	NM_182508.2	NP_872314.1	Q8N7L0	CM030_HUMAN	family with sequence similarity 216, member B	16																	ATGTTCCACAACTTCCTTTTA	0.348000													24	61					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61502471	61502471	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:61502471T>C	ENST00000257215.5	+	10	1241	c.1125T>C	c.(1123-1125)gaT>gaC	p.D375D		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	375					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		CCTGCCATGATGCGGTGAGGC	0.622000													32	343					0	0	1	0	0
MCMDC2	157777	broad.mit.edu	37	8	67808486	67808486	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:67808486T>C	ENST00000422365.2	+	11	1532	c.1361T>C	c.(1360-1362)gTt>gCt	p.V454A	MCMDC2_ENST00000396592.3_Missense_Mutation_p.V454A|MCMDC2_ENST00000313616.5_Missense_Mutation_p.V454A|MCMDC2_ENST00000541540.1_Missense_Mutation_p.V391A	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	454					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						ACTTTTCCAGTTCAGTGCAGT	0.388000													5	165					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46239047	46239047	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46239047A>G	ENST00000252934.5	+	11	1679	c.1414A>G	c.(1414-1416)Acc>Gcc	p.472_472insA	ATXN10_ENST00000402380.3_Missense_Mutation_p.123_123insA|ATXN10_ENST00000381061.4_Missense_Mutation_p.408_408insA	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	0					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		TACTAGAGACACCCCTAAGCC	0.468000													9	82					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	860989	860989	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:860989C>T	ENST00000316157.3	-	15	1757	c.1717G>A	c.(1717-1719)Gtg>Atg	p.V573M	LARP4B_ENST00000469487.1_5'UTR	NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	573							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						AGGGTGTTCACGCTTGCGTCT	0.592000													27	76					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29848107	29848107	+	Silent	SNP	C	C	T	rs150643395	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:29848107C>T	ENST00000399218.4	-	6	2410	c.2355G>A	c.(2353-2355)ccG>ccA	p.P785P	GAREM_ENST00000269209.6_Silent_p.P786P	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		GGAGATGGAGCGGAGATGAGA	0.547000													14	43					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67319354	67319354	+	Missense_Mutation	SNP	G	G	A	rs150434910		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67319354G>A	ENST00000360461.5	+	13	4892	c.2357G>A	c.(2356-2358)cGg>cAg	p.R786Q	PLEKHG4_ENST00000450733.1_Missense_Mutation_p.R705Q|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.R786Q|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.R786Q	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	786	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.R786L(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		GAGAAGCTGCGGGACTTCCAC	0.632000													5	152					0	0	1	0	0
RWDD2B	10069	broad.mit.edu	37	21	30380082	30380082	+	Splice_Site	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:30380082C>A	ENST00000493196.1	-	4	825	c.725_splice	c.e4+1	p.R242_splice	RWDD2B_ENST00000486719.1_5'UTR	NM_016940.2	NP_058636.1	P57060	RWD2B_HUMAN	RWD domain containing 2B	242										endometrium(1)|kidney(1)|large_intestine(8)|lung(2)	12						AAAAGCAAACCTTGACCAGAA	0.428000													14	65					0.00400662	0.00403976	1	1	0
OPA1	4976	broad.mit.edu	37	3	193377314	193377314	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:193377314G>C	ENST00000361510.2	+	25	2718	c.2484G>C	c.(2482-2484)aaG>aaC	p.K828N	OPA1_ENST00000361908.3_Missense_Mutation_p.K810N|OPA1_ENST00000361150.2_Missense_Mutation_p.K774N|OPA1_ENST00000392438.3_Missense_Mutation_p.K773N|OPA1_ENST00000361828.2_Missense_Mutation_p.K791N|OPA1_ENST00000361715.2_Missense_Mutation_p.K792N	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	773					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		ACTGGAAAAAGAGGTGGTTAT	0.308000													11	18					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24933863	24933863	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:24933863C>T	ENST00000405141.1	+	15	3193	c.2482C>T	c.(2482-2484)Cca>Tca	p.P828S	NCOA1_ENST00000348332.3_Missense_Mutation_p.P828S|NCOA1_ENST00000288599.5_Missense_Mutation_p.P828S|NCOA1_ENST00000538539.1_Missense_Mutation_p.P828S|NCOA1_ENST00000395856.3_Missense_Mutation_p.P828S|NCOA1_ENST00000407230.1_Missense_Mutation_p.P677S|NCOA1_ENST00000406961.1_Missense_Mutation_p.P828S			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	828	Interaction with CREBBP.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCACAGTTGCCAGGCTTATG	0.488000			T	PAX3	alveolar rhadomyosarcoma								4	81					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56519603	56519603	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:56519603T>A	ENST00000245157.5	-	16	2378	c.1958A>T	c.(1957-1959)gAc>gTc	p.D653V	BBS2_ENST00000568104.1_Missense_Mutation_p.D607V	NM_031885.3	NP_114091.3	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	653					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						ATTTAGCAAGTCTCTATTAAG	0.378000									Bardet-Biedl syndrome				34	126					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57575889	57575889	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:57575889C>T	ENST00000524630.1	+	13	2614	c.2101C>T	c.(2101-2103)Cgt>Tgt	p.R701C	CTNND1_ENST00000528621.1_Missense_Mutation_p.R647C|CTNND1_ENST00000415361.2_Missense_Mutation_p.R606C|CTNND1_ENST00000426142.2_Missense_Mutation_p.R600C|CTNND1_ENST00000526772.1_Missense_Mutation_p.R378C|CTNND1_ENST00000534579.1_Missense_Mutation_p.R647C|CTNND1_ENST00000529986.1_Missense_Mutation_p.R600C|CTNND1_ENST00000532463.1_Missense_Mutation_p.R600C|CTNND1_ENST00000428599.2_Missense_Mutation_p.R701C|CTNND1_ENST00000361796.4_Missense_Mutation_p.R701C|CTNND1_ENST00000526357.1_Missense_Mutation_p.R647C|CTNND1_ENST00000361332.4_Missense_Mutation_p.R701C|CTNND1_ENST00000529919.1_Missense_Mutation_p.R707C|CTNND1_ENST00000525902.1_Missense_Mutation_p.R384C|CTNND1_ENST00000526938.1_Missense_Mutation_p.R707C|CTNND1_ENST00000399050.4_Missense_Mutation_p.R707C|CTNND1_ENST00000528232.1_Missense_Mutation_p.R606C|CTNND1_ENST00000527467.1_Missense_Mutation_p.R384C|CTNND1_ENST00000532649.1_Missense_Mutation_p.R647C|CTNND1_ENST00000532245.1_Missense_Mutation_p.R600C|CTNND1_ENST00000531014.1_Missense_Mutation_p.R378C|CTNND1_ENST00000530094.1_Missense_Mutation_p.R600C|CTNND1_ENST00000360682.6_Missense_Mutation_p.R707C|CTNND1_ENST00000399039.4_Missense_Mutation_p.R707C|CTNND1_ENST00000532787.1_Missense_Mutation_p.R600C|CTNND1_ENST00000532844.1_Missense_Mutation_p.R653C|CTNND1_ENST00000529526.1_Missense_Mutation_p.R647C|CTNND1_ENST00000529873.1_Missense_Mutation_p.R647C|CTNND1_ENST00000361391.6_Missense_Mutation_p.R701C|CTNND1_ENST00000358694.6_Missense_Mutation_p.R701C|CTNND1_ENST00000530748.1_Missense_Mutation_p.R653C|CTNND1_ENST00000533667.1_Missense_Mutation_p.R378C			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	707					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				CTCTGCTCTGCGTCAAGAGAA	0.458000													5	150					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45889353	45889353	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45889353G>A	ENST00000418234.2	-	9	1979	c.1901C>T	c.(1900-1902)gCg>gTg	p.A634V	PPP1R13L_ENST00000360957.5_Missense_Mutation_p.A634V	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	634					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GGTCAGCGCCGCGTCCAGGAG	0.741000													3	14					0	0	1	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14183992	14183992	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:14183992T>C	ENST00000581935.1	+	0	681																				lung(3)	3						AATCCAAACCTTAAGGATATC	0.448000													8	213					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116276863	116276863	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:116276863G>A	ENST00000374140.2	+	16	1812	c.1603G>A	c.(1603-1605)Gcc>Acc	p.A535T	RGS3_ENST00000343817.5_Missense_Mutation_p.A254T|RGS3_ENST00000317613.6_Missense_Mutation_p.A423T|RGS3_ENST00000350696.5_Missense_Mutation_p.A535T|RGS3_ENST00000394646.3_Missense_Mutation_p.A254T|RGS3_ENST00000374136.1_Missense_Mutation_p.A161T	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	535					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GAGGCCGCATGCCACGCACTC	0.587000													32	102					0	0	1	0	0
BTG1	694	broad.mit.edu	37	12	92539207	92539207	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:92539207T>C	ENST00000256015.3	-	1	466	c.105A>G	c.(103-105)cgA>cgG	p.R35R		NM_001731.2	NP_001722.1	P62324	BTG1_HUMAN	B-cell translocation gene 1, anti-proliferative	35					cell migration|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|regulation of apoptosis|regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|transcription cofactor activity			haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(1)|lung(2)	16		Acute lymphoblastic leukemia(6;3.02e-13)|all_hematologic(6;4.32e-09)				TCTGCAGCTGTCGCTCGCTCG	0.667000			T	MYC	BCLL								13	66					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139938224	139938224	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:139938224G>C	ENST00000357560.4	-	13	1850	c.1407C>G	c.(1405-1407)gtC>gtG	p.V469V	APBB3_ENST00000354402.5_Silent_p.V476V|APBB3_ENST00000358580.5_3'UTR|APBB3_ENST00000508496.2_Silent_p.V246V|APBB3_ENST00000412920.3_Silent_p.V467V|APBB3_ENST00000356738.2_Silent_p.V474V	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	469						actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAAGAGAAGACACCCCGCT	0.597000													69	168					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266654	41266654	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:41266654C>T	ENST00000349496.5	+	4	731	c.451C>T	c.(451-453)Cgt>Tgt	p.R151C	CTNNB1_ENST00000405570.1_Missense_Mutation_p.R151C|CTNNB1_ENST00000396183.3_Missense_Mutation_p.R151C|CTNNB1_ENST00000396185.3_Missense_Mutation_p.R151C|CTNNB1_ENST00000453024.1_Missense_Mutation_p.R144C	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	151					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.M1_V173del(1)|p.I35_K170del(1)|p.A13_R151del(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	ACTTGCCACACGTGCAATCCC	0.428000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				18	68					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343138	130343138	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:130343138T>C	ENST00000299164.2	+	8	2275	c.2275T>C	c.(2275-2277)Tac>Cac	p.Y759H		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	759	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TCTGCTGCGGTACAGCGGCAC	0.662000													8	136					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62261570	62261570	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:62261570A>G	ENST00000474889.1	+	24	3865	c.3488A>G	c.(3487-3489)aAa>aGa	p.K1163R	PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.K1134R|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1163	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TGTAATGCAAAATATGTGGAA	0.333000													5	43					0	0	1	0	0
ZNF252P	286101	broad.mit.edu	37	8	146220493	146220493	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:146220493C>T	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						GCAGCCACCTCAAGATCACAG	0.468000													14	31					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12943919	12943919	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:12943919A>G	ENST00000276297.4	-	17	4755	c.4346T>C	c.(4345-4347)gTg>gCg	p.V1449A	DLC1_ENST00000512044.2_Missense_Mutation_p.V1046A|DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000520226.1_Missense_Mutation_p.V938A|DLC1_ENST00000358919.2_Missense_Mutation_p.V1012A	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1449	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						ATCGTGATCCACAGAGGTTAG	0.478000													5	167					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158487492	158487492	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:158487492G>T	ENST00000355585.4	+	12	1617	c.1542G>T	c.(1540-1542)ctG>ctT	p.L514L	SYNJ2_ENST00000367121.3_Silent_p.L514L|SYNJ2_ENST00000449859.2_Silent_p.L442L|SYNJ2_ENST00000367122.2_Silent_p.L514L	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	514							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CCAGGATCCTGAAAGCTATGA	0.507000													15	61					2.23348e-06	2.28775e-06	1	1	0
NKX2-4	644524	broad.mit.edu	37	20	21376835	21376835	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:21376835C>T	ENST00000351817.4	-	2	1407	c.779G>A	c.(778-780)gGc>gAc	p.G260D		NM_033176.1	NP_149416.1	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	260					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|upper_aerodigestive_tract(1)	3						gcccaggccgcccTCCTGCTG	0.711000													4	6					0	0	1	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48519200	48519200	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:48519200A>C	ENST00000339841.2	+	4	437	c.259A>C	c.(259-261)Agc>Cgc	p.S87R	ELSPBP1_ENST00000597519.1_Intron	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	87	Fibronectin type-II 2.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GGCTTATAACAGCTGCATCTC	0.468000													29	74					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132952768	132952768	+	Silent	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:132952768T>G	ENST00000254624.5	+	2	258	c.33T>G	c.(31-33)gcT>gcG	p.A11A	EFR3A_ENST00000519656.1_5'UTR|EFR3A_ENST00000334503.4_Silent_p.A11A	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	11						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			GCTGTTCCGCTTTGCGTCCTC	0.373000													6	13					0	0	1	0	0
EFNB3	1949	broad.mit.edu	37	17	7609005	7609005	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7609005T>C	ENST00000226091.2	+	1	486	c.89T>C	c.(88-90)cTg>cCg	p.L30P		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	30					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				GGGCTCAGCCTGGAGCCTGTC	0.682000													19	58					0	0	1	0	0
OR52B6	340980	broad.mit.edu	37	11	5602245	5602245	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5602245C>T	ENST00000345043.2	+	1	139	c.139C>T	c.(139-141)Ctg>Ttg	p.L47L	HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATATCTGGCTGTCCATCCC	0.507000													14	64					0	0	1	0	0
RNPS1	10921	broad.mit.edu	37	16	2313109	2313109	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2313109C>T	ENST00000565678.1	-	4	952	c.407G>A	c.(406-408)cGc>cAc	p.R136H	RNPS1_ENST00000301730.8_Missense_Mutation_p.R136H|RNPS1_ENST00000320225.5_Missense_Mutation_p.R136H|RNPS1_ENST00000568631.1_Missense_Mutation_p.R136H|RNPS1_ENST00000569598.2_Missense_Mutation_p.R42H|RNPS1_ENST00000397086.2_Missense_Mutation_p.R136H|RNPS1_ENST00000566397.1_5'UTR|RNPS1_ENST00000566458.1_Missense_Mutation_p.R113H|RNPS1_ENST00000561718.1_5'UTR|RNPS1_ENST00000567147.1_Missense_Mutation_p.R113H			Q15287	RNPS1_HUMAN	RNA binding protein S1, serine-rich domain	136	Arg-rich.|Necessary for interaction with SRP54, nuclear localization and exon-skipping.|Necessary for interaction with the cleaved p110 isoform of CDC2L1.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|urinary_tract(1)	9						GGAGCGGGAGCGCCTCCTGTT	0.582000													14	51					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94680114	94680114	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:94680114G>T	ENST00000377047.4	+	4	1458	c.843G>T	c.(841-843)caG>caT	p.Q281H		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	281						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TGGCAAATCAGGCTGACCTCG	0.493000													44	104					1.76056e-25	1.86429e-25	1	1	0
FBXO7	25793	broad.mit.edu	37	22	32894221	32894221	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:32894221T>C	ENST00000266087.7	+	9	1600	c.1273T>C	c.(1273-1275)Tat>Cat	p.Y425H	FBXO7_ENST00000397426.1_Missense_Mutation_p.Y311H|FBXO7_ENST00000382058.3_Missense_Mutation_p.Y346H	NM_012179.3	NP_036311.3	Q9Y3I1	FBX7_HUMAN	F-box protein 7	425					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CATTCCATTCTATCCCAACCC	0.498000													20	203					0	0	1	0	0
CCBL2	56267	broad.mit.edu	37	1	89408720	89408720	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:89408720A>G	ENST00000260508.4	-	13	1607	c.1270T>C	c.(1270-1272)Ttt>Ctt	p.F424L	CCBL2_ENST00000370485.2_3'UTR|CCBL2_ENST00000370491.3_Missense_Mutation_p.F390L|CCBL2_ENST00000446900.2_5'UTR	NM_001008661.2	NP_001008661.1	Q6YP21	KAT3_HUMAN	cysteine conjugate-beta lyase 2	424					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			endometrium(3)|kidney(4)|large_intestine(2)|lung(4)|ovary(2)|skin(2)|soft_tissue(1)	18		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AACTTCTCAAACTGTGATTTA	0.303000													60	214					0	0	1	0	0
SLC38A2	54407	broad.mit.edu	37	12	46759025	46759025	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:46759025A>G	ENST00000551374.1	-	1	65	c.25T>C	c.(25-27)Tat>Cat	p.Y9H	SLC38A2_ENST00000547252.1_Intron|SLC38A2_ENST00000256689.5_Intron			Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	0	Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	18	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		TCTGAAAAATATACACATCTT	0.348000													17	24					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065129	73065129	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:73065129A>G	ENST00000429829.1	-	0	7459					NR_001564.2																						CACACACATAACAGGCCAGGA	0.507000													67	63					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149265933	149265933	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:149265933C>A	ENST00000255266.5	-	14	1852	c.1733G>T	c.(1732-1734)gGa>gTa	p.G578V		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	578					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTTCAGCTTTCCCGTCTGGAA	0.532000													12	40					0.00010058	0.000102188	1	1	0
SULT1E1	6783	broad.mit.edu	37	4	70721142	70721142	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:70721142T>C	ENST00000226444.3	-	3	260	c.148A>G	c.(148-150)Aca>Gca	p.T50A		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	50					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						ACCCAGGTTGTACCTGTAAAA	0.368000													5	45					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66459127	66459127	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:66459127A>G	ENST00000404260.3	+	29	4437	c.4129A>G	c.(4129-4131)Atc>Gtc	p.I1377V	MAST4_ENST00000403625.2_Missense_Mutation_p.I1374V|MAST4_ENST00000405643.1_Missense_Mutation_p.I1195V|MAST4_ENST00000261569.7_Missense_Mutation_p.I1180V|MAST4_ENST00000403666.1_Missense_Mutation_p.I1185V			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1377						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CGCCGGCAACATCCCACTGTC	0.682000													36	106					0	0	1	0	0
CTLA4	1493	broad.mit.edu	37	2	204735498	204735498	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:204735498A>T	ENST00000302823.3	+	2	456	c.299A>T	c.(298-300)gAt>gTt	p.D100V	CTLA4_ENST00000427473.2_Missense_Mutation_p.D63V|CTLA4_ENST00000295854.6_Missense_Mutation_p.D100V|CTLA4_ENST00000472206.1_Intron|CTLA4_ENST00000487393.1_Intron	NM_005214.4	NP_005205.2	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	100	Ig-like V-type.				B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm				large_intestine(4)|lung(4)|skin(1)	9					Abatacept(DB01281)	TTCCTAGATGATTCCATCTGC	0.552000													38	119					0	0	1	0	0
UST	10090	broad.mit.edu	37	6	149342555	149342555	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:149342555T>C	ENST00000367463.4	+	7	978	c.875T>C	c.(874-876)cTg>cCg	p.L292P		NM_005715.2	NP_005706.1	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	292					protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(2)	12		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		GATGTGCTGCTGTTACTGGAA	0.458000													25	66					0	0	1	0	0
MRPL47	57129	broad.mit.edu	37	3	179310503	179310503	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:179310503T>C	ENST00000476781.1	-	6	587	c.558A>G	c.(556-558)atA>atG	p.I186M	MRPL47_ENST00000259038.2_Missense_Mutation_p.I166M|MRPL47_ENST00000392659.2_Missense_Mutation_p.I76M	NM_020409.2	NP_065142.2	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47	186					translation	mitochondrial ribosome	structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|stomach(1)	11	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			GGTGCCAAGGTATAACCCACT	0.343000													8	27					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62066963	62066963	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:62066963T>C	ENST00000404929.1	-	3	1187	c.1176A>G	c.(1174-1176)ttA>ttG	p.L392L	FAM161A_ENST00000405894.3_Silent_p.L392L	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	392					response to stimulus|visual perception	centrosome		p.L283F(1)		breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATGAGTTCTGTAAATGCTCCT	0.458000													21	67					0	0	1	0	0
TRIM32	22954	broad.mit.edu	37	9	119461806	119461806	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:119461806T>C	ENST00000450136.1	+	2	1946	c.1785T>C	c.(1783-1785)agT>agC	p.S595S	ASTN2_ENST00000361477.3_Intron|ASTN2_ENST00000373996.3_Intron|ASTN2_ENST00000313400.4_Intron|ASTN2_ENST00000361209.2_Intron|TRIM32_ENST00000373983.2_Silent_p.S595S	NM_001099679.1|NM_012210.3	NP_001093149.1|NP_036342.2	Q13049	TRI32_HUMAN	tripartite motif containing 32	595					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	26						CTGACAGTAGTCGCAAGGAAA	0.527000													18	60					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70048869	70048869	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:70048869A>G	ENST00000370598.1	+	25	4071	c.3250A>G	c.(3250-3252)Aca>Gca	p.T1084A	BAI3_ENST00000238918.8_Missense_Mutation_p.T290A|BAI3_ENST00000546190.1_Missense_Mutation_p.T48A	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1084					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				AGTAGTTTCAACAACAGCTTT	0.418000													13	130					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140811791	140811791	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140811791T>C	ENST00000371372.1	+	6	1019	c.874T>C	c.(874-876)Ttt>Ctt	p.F292L	CACNA1B_ENST00000371357.1_Missense_Mutation_p.F292L|CACNA1B_ENST00000277551.2_Missense_Mutation_p.F292L|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371363.1_Missense_Mutation_p.F292L|CACNA1B_ENST00000371355.4_Missense_Mutation_p.F292L	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	292					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity	p.F292V(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGGACCCAACTTTGGCATCAC	0.582000													37	106					0	0	1	0	0
MSMP	692094	broad.mit.edu	37	9	35753693	35753693	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35753693G>A	ENST00000436428.2	-	2	342	c.203C>T	c.(202-204)aCc>aTc	p.T68I	MSMP_ENST00000414286.1_5'UTR|RGP1_ENST00000378078.4_3'UTR	NM_001044264.2	NP_001037729.1	Q1L6U9	MSMP_HUMAN	microseminoprotein, prostate associated	68						extracellular region				endometrium(2)|kidney(1)|lung(3)|prostate(3)	9						ATGCAGACAGGTGCAATGGAA	0.522000													10	35					0	0	1	0	0
TM9SF3	56889	broad.mit.edu	37	10	98311121	98311121	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98311121A>G	ENST00000371142.4	-	7	1056	c.840T>C	c.(838-840)gaT>gaC	p.D280D	TM9SF3_ENST00000490192.1_5'UTR	NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	280						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		GTCTAAATACATCTCCATGCA	0.358000													9	128					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51394560	51394560	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:51394560A>G	ENST00000266037.9	+	44	4694	c.4671A>G	c.(4669-4671)gcA>gcG	p.A1557A		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1557	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GAGGCATTGCACGCTATCAGG	0.517000													30	133					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204957844	204957844	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:204957844G>A	ENST00000367172.4	+	25	3326	c.2998G>A	c.(2998-3000)Gtg>Atg	p.V1000M	NFASC_ENST00000338586.6_Missense_Mutation_p.V1000M|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000339876.6_Missense_Mutation_p.V893M|NFASC_ENST00000404907.1_Missense_Mutation_p.V996M|NFASC_ENST00000539706.1_Missense_Mutation_p.V996M|NFASC_ENST00000401399.1_Missense_Mutation_p.V893M|NFASC_ENST00000360049.4_Missense_Mutation_p.V996M|NFASC_ENST00000367170.4_Missense_Mutation_p.V1000M|NFASC_ENST00000404076.1_Missense_Mutation_p.V979M|NFASC_ENST00000513543.1_Missense_Mutation_p.V996M|NFASC_ENST00000367171.4_Missense_Mutation_p.V985M|NFASC_ENST00000367169.4_Missense_Mutation_p.V893M|NFASC_ENST00000338515.6_Missense_Mutation_p.V1000M			O94856	NFASC_HUMAN	neurofascin	1000	Fibronectin type-III 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AACGGACCCCGTGTCACGCTA	0.562000													33	97					0	0	1	0	0
OSCAR	126014	broad.mit.edu	37	19	54598534	54598534	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54598534A>G	ENST00000358375.4	-	5	789	c.744T>C	c.(742-744)acT>acC	p.T248T	OSCAR_ENST00000391761.1_3'UTR|OSCAR_ENST00000356532.3_Silent_p.T252T|OSCAR_ENST00000359649.4_3'UTR|OSCAR_ENST00000351806.4_Silent_p.T237T|OSCAR_ENST00000284648.6_3'UTR	NM_133169.3	NP_573399.1	Q8IYS5	OSCAR_HUMAN	osteoclast associated, immunoglobulin-like receptor	0						extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(1)|skin(1)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					GCCAGTCAAAAGTGACCAGCG	0.677000													7	23					0	0	1	0	0
MSS51	118490	broad.mit.edu	37	10	75187958	75187958	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:75187958T>G	ENST00000299432.2	-	2	150	c.85A>C	c.(85-87)Acc>Ccc	p.T29P	MSS51_ENST00000372912.1_Missense_Mutation_p.T29P	NM_001024593.1	NP_001019764.1	Q4VC12	ZMY17_HUMAN	MSS51 mitochondrial translational activator	29							zinc ion binding										GGCACAGGGGTCACAATTGTG	0.557000													6	82					0	0	1	0	0
TANGO6	79613	broad.mit.edu	37	16	68961841	68961841	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:68961841G>A	ENST00000261778.1	+	13	2510	c.2498G>A	c.(2497-2499)aGc>aAc	p.S833N	RP11-521L9.1_ENST00000562790.1_lincRNA	NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		AAATCTGGAAGCGTAACCACA	0.512000													7	32					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3688681	3688681	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:3688681C>T	ENST00000250699.2	-	4	747	c.676G>A	c.(676-678)Gtc>Atc	p.V226I	CHRNA10_ENST00000534359.1_Silent_p.T43T	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	226					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GTGAAGGTGACGTCGGGGTAG	0.716000													4	32					0	0	1	0	0
SLC25A35	399512	broad.mit.edu	37	17	8197893	8197893	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:8197893C>T	ENST00000380067.2	-	1	277	c.233G>A	c.(232-234)gGc>gAc	p.G78D	SLC25A35_ENST00000579192.1_Missense_Mutation_p.G78D|SLC25A35_ENST00000577745.1_Missense_Mutation_p.G78D|SLC25A35_ENST00000396278.1_Missense_Mutation_p.G78D|SLC25A35_ENST00000580340.1_Missense_Mutation_p.G78D	NM_201520.1	NP_958928.1	Q3KQZ1	S2535_HUMAN	solute carrier family 25, member 35	78					transport	integral to membrane|mitochondrial inner membrane				breast(2)|large_intestine(2)|lung(2)	6						CAGTCGGATGCCATTCATCAG	0.632000													12	68					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90482396	90482396	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:90482396A>G	ENST00000369393.3	-	14	2094	c.1979T>C	c.(1978-1980)aTc>aCc	p.I660T	MDN1_ENST00000428876.1_Missense_Mutation_p.I660T			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	660			I -> V (in dbSNP:rs12110451).		protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAGCTGCTCGATGAGAACAGA	0.507000													27	126					0	0	1	0	0
SLC39A9	55334	broad.mit.edu	37	14	69866167	69866167	+	Silent	SNP	T	T	A	rs111934367		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:69866167T>A	ENST00000031146.4	+	1	759	c.81T>A	c.(79-81)gcT>gcA	p.A27A	SLC39A9_ENST00000555245.1_Intron|SLC39A9_ENST00000556605.1_Silent_p.A27A|SLC39A9_ENST00000557046.1_Silent_p.A27A|SLC39A9_ENST00000336643.5_Silent_p.A27A			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	27					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		TTCCCTTGGCTGTTAATTTCT	0.448000													11	24					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65309448	65309448	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:65309448T>C	ENST00000284037.5	+	6	847	c.458T>C	c.(457-459)tTg>tCg	p.L153S	ERBB2IP_ENST00000380936.1_Missense_Mutation_p.L153S|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.L153S|ERBB2IP_ENST00000416865.2_Missense_Mutation_p.L153S|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.L153S|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.L153S|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.L153S|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.L153S|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.L153S|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.L153S	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	153					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		CTTGAGTTCTTGCCAGCAAAT	0.333000													18	89					0	0	1	0	0
CCT4	10575	broad.mit.edu	37	2	62099690	62099690	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:62099690T>C	ENST00000394440.3	-	11	1455	c.1159A>G	c.(1159-1161)Aca>Gca	p.T387A	CCT4_ENST00000461540.2_Intron|AC107081.5_ENST00000425779.1_RNA|CCT4_ENST00000538252.1_Missense_Mutation_p.T331A|CCT4_ENST00000544079.1_Missense_Mutation_p.T357A|CCT4_ENST00000544185.1_Missense_Mutation_p.T237A	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	387					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding	p.T387A(1)		breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			ACAACAATTGTAACTGTTTTT	0.428000													24	78					0	0	1	0	0
IRAK4	51135	broad.mit.edu	37	12	44180497	44180497	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:44180497G>A	ENST00000431837.1	+	11	1298	c.990G>A	c.(988-990)ctG>ctA	p.L330L	IRAK4_ENST00000448290.2_Silent_p.L454L|IRAK4_ENST00000440781.2_Silent_p.L330L|IRAK4_ENST00000551736.1_Silent_p.L454L	NM_001145256.1|NM_001145257.1	NP_001138728.1|NP_001138729.1	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	454	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity					all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		AACAGCTGCTGCAAGAGATGA	0.299000													14	58					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11354567	11354567	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:11354567T>C	ENST00000315872.6	-	17	2407	c.1959A>G	c.(1957-1959)gaA>gaG	p.E653E	ROCK2_ENST00000401753.1_Silent_p.E410E	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	653	Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TCTTTAAATCTTCTTCTAGGC	0.313000													13	41					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140705943	140705943	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140705943T>C	ENST00000460843.1	+	19	2770	c.2743T>C	c.(2743-2745)Ttc>Ctc	p.F915L		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	915					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CTGGGCGGCGTTCTCCGGCTG	0.637000													32	68					0	0	1	0	0
DLGAP5	9787	broad.mit.edu	37	14	55649131	55649131	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:55649131C>T	ENST00000247191.2	-	4	668	c.452G>A	c.(451-453)cGg>cAg	p.R151Q	DLGAP5_ENST00000395425.2_Missense_Mutation_p.R151Q	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	151					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						CCTTGTAATCCGTACAGAAGA	0.313000													32	102					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1585075	1585075	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1585075G>A	ENST00000590550.2	-	1	454	c.81C>T	c.(79-81)taC>taT	p.Y27Y	MBD3_ENST00000592012.1_Silent_p.Y51Y|MBD3_ENST00000434436.3_Silent_p.Y83Y|MBD3_ENST00000156825.1_Silent_p.Y83Y|MBD3_ENST00000585967.1_5'UTR			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	83	MBD.				transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGGAGTCGTAGCGCACGC	0.662000													16	40					0	0	1	0	0
SPATA6L	55064	broad.mit.edu	37	9	4625426	4625426	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:4625426A>G	ENST00000454239.2	-	7	815	c.570T>C	c.(568-570)taT>taC	p.Y190Y	SPATA6L_ENST00000381895.5_Silent_p.Y67Y|SPATA6L_ENST00000475086.1_Silent_p.Y132Y|SPATA6L_ENST00000223517.5_5'UTR|SPATA6L_ENST00000381890.5_Silent_p.Y204Y			B4DIY4	B4DIY4_HUMAN	spermatogenesis associated 6-like	132																	GCCTGGTAGAATATTGAGAGG	0.428000													5	72					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144523233	144523233	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144523233G>A	ENST00000262577.5	-	10	2396	c.2365C>T	c.(2365-2367)Cgc>Tgc	p.R789C		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	789					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TGGGCGCCGCGGGGACACGCC	0.711000													7	18					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76491108	76491108	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:76491108T>C	ENST00000389840.5	-	39	6057	c.5933A>G	c.(5932-5934)gAa>gGa	p.E1978G	DNAH17_ENST00000585328.1_Missense_Mutation_p.E1987G|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AAGGCGGGCTTCCAGAAAGCC	0.607000													3	23					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61778301	61778301	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:61778301G>A	ENST00000423902.2	+	38	9282	c.8803G>A	c.(8803-8805)Gaa>Aaa	p.E2935K	CHD7_ENST00000524602.1_Missense_Mutation_p.E886K	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2935					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGGCTCCAGCGAAGAAAAGGC	0.567000													27	86					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70497604	70497604	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:70497604T>A	ENST00000288078.6	+	3	393	c.161T>A	c.(160-162)gTg>gAg	p.V54E	FUK_ENST00000571514.1_Intron|FUK_ENST00000428974.2_Missense_Mutation_p.V54E|FUK_ENST00000378912.2_Missense_Mutation_p.V54E	NM_145059.2	NP_659496.2	Q8N0W3	FUK_HUMAN	fucokinase	54						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				GAGAAGCGTGTGGGCAGCGGA	0.642000													27	61					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67812917	67812917	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:67812917A>G	ENST00000255674.6	-	18	2698	c.2412T>C	c.(2410-2412)gtT>gtC	p.V804V	RTTN_ENST00000437017.1_Silent_p.V804V|RTTN_ENST00000454359.1_Silent_p.V804V	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	804							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				ATAAATCAGTAACTCTGGAGA	0.398000													7	109					0	0	1	0	0
ITFG1	81533	broad.mit.edu	37	16	47494827	47494827	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:47494827C>T	ENST00000320640.6	-	1	358	c.130G>A	c.(130-132)Gcc>Acc	p.A44T	ITFG1_ENST00000544001.2_Intron	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	44						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				CAGGCCTCGGCCCCAAAGAGC	0.687000													8	18					0	0	1	0	0
TIMP2	7077	broad.mit.edu	37	17	76867073	76867073	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:76867073C>G	ENST00000262768.7	-	3	545	c.247G>C	c.(247-249)Gag>Cag	p.E83Q	TIMP2_ENST00000586057.1_Missense_Mutation_p.E6Q|TIMP2_ENST00000585421.1_Missense_Mutation_p.E6Q|TIMP2_ENST00000536189.2_Missense_Mutation_p.E6Q	NM_003255.4	NP_003246.1	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2	83	NTR.						metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			ATATCCTTCTCAGGCCCTTTG	0.532000													42	91					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54933949	54933949	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:54933949A>G	ENST00000284061.3	+	8	1355	c.1175A>G	c.(1174-1176)aAg>aGg	p.K392R		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	392					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					CATCGTGAGAAGGCACCATCT	0.373000													5	20					0	0	1	0	0
ACOT9	23597	broad.mit.edu	37	X	23723708	23723708	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:23723708G>A	ENST00000379303.5	-	13	1065	c.937C>T	c.(937-939)Cgg>Tgg	p.R313W	ACOT9_ENST00000379295.1_Missense_Mutation_p.R244W|ACOT9_ENST00000336430.7_Missense_Mutation_p.R304W	NM_001037171.1	NP_001032248.1	Q9Y305	ACOT9_HUMAN	acyl-CoA thioesterase 9	304					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(4)|pancreas(1)|skin(1)	15						AAAATGTTCCGCTCCTACAGG	0.408000													50	56					0	0	1	0	0
OPN5	221391	broad.mit.edu	37	6	47779420	47779420	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:47779420G>A	ENST00000489301.2	+	6	1094	c.1009G>A	c.(1009-1011)Gta>Ata	p.V337I	OPN5_ENST00000371211.2_Missense_Mutation_p.V337I|OPN5_ENST00000244799.4_3'UTR|OPN5_ENST00000393699.2_Missense_Mutation_p.V337I			Q6U736	OPN5_HUMAN	opsin 5	337					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						GCTGCACACCGTAACCACAGT	0.358000													16	61					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56470188	56470188	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:56470188T>C	ENST00000370754.5	-	39	9138	c.9139A>G	c.(9139-9141)Aat>Gat	p.N3047D	DST_ENST00000370769.4_Missense_Mutation_p.N2869D|DST_ENST00000312431.6_Missense_Mutation_p.N2869D|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000446842.2_Missense_Mutation_p.N2543D|DST_ENST00000361203.3_Missense_Mutation_p.N2869D|DST_ENST00000244364.6_Intron			Q03001	DYST_HUMAN	dystonin	2869					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCCCTTGTATTTTTACCAGGC	0.338000													13	44					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89416862	89416862	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:89416862A>G	ENST00000490686.1	-	0	348																											AGACAGTAATAAGTTGCAAAA	0.517000													6	222					0	0	1	0	0
PAK3	5063	broad.mit.edu	37	X	110385398	110385398	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:110385398T>C	ENST00000519681.1	+	6	692	c.250T>C	c.(250-252)Ttt>Ctt	p.F84L	PAK3_ENST00000360648.4_Missense_Mutation_p.F84L|PAK3_ENST00000372007.4_Missense_Mutation_p.F84L|PAK3_ENST00000425146.1_Missense_Mutation_p.F84L|PAK3_ENST00000262836.4_Missense_Mutation_p.F84L|PAK3_ENST00000372010.1_Missense_Mutation_p.F84L|PAK3_ENST00000446737.1_Missense_Mutation_p.F84L|PAK3_ENST00000417227.1_Missense_Mutation_p.F84L|PAK3_ENST00000518291.1_Missense_Mutation_p.F84L			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	84	Autoregulatory region (By similarity).|GTPase-binding (By similarity).|Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						TCATGTGGGGTTTGATGCAGT	0.393000										TSP Lung(19;0.15)			6	116					0	0	1	0	0
FAM174A	345757	broad.mit.edu	37	5	99871267	99871267	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:99871267C>T	ENST00000312637.4	+	1	259	c.33C>T	c.(31-33)agC>agT	p.S11S		NM_198507.1	NP_940909.1	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	11						integral to membrane				breast(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						GCTGTCTCAGCCACCTCTTGG	0.687000													5	188					0	0	1	0	0
PSMB3	5691	broad.mit.edu	37	17	36912171	36912171	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:36912171A>T	ENST00000225426.4	+	3	315	c.224A>T	c.(223-225)gAg>gTg	p.E75V		NM_002795.2	NP_002786.2	P49720	PSB3_HUMAN	proteasome (prosome, macropain) subunit, beta type, 3	75					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)	4						AACCTGTATGAGTTGAAGGAA	0.478000													19	67					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39735874	39735874	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:39735874T>C	ENST00000395670.3	-	13	2184	c.1765A>G	c.(1765-1767)Aag>Gag	p.K589E	KIF21A_ENST00000361418.5_Missense_Mutation_p.K589E|KIF21A_ENST00000541463.2_Missense_Mutation_p.K576E|KIF21A_ENST00000544797.2_Missense_Mutation_p.K576E|KIF21A_ENST00000361961.3_Missense_Mutation_p.K576E			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	589					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				GAAACACCCTTTTCTTCTTTC	0.353000													5	28					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26962548	26962548	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:26962548A>G	ENST00000528896.2	-	16	2131	c.2057T>C	c.(2056-2058)cTa>cCa	p.L686P	RP11-192H23.7_ENST00000577814.1_RNA|KIAA0100_ENST00000389003.3_Missense_Mutation_p.L543P|KIAA0100_ENST00000544884.1_Missense_Mutation_p.L543P	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	686						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					TCGGCACTGTAGAGTGGCCAG	0.527000													35	69					0	0	1	0	0
PI15	51050	broad.mit.edu	37	8	75761352	75761352	+	Splice_Site	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:75761352G>T	ENST00000260113.2	+	6	820		c.e6-1		RP11-758M4.4_ENST00000522914.1_RNA|RP11-758M4.4_ENST00000518128.1_RNA|RP11-758M4.4_ENST00000523860.1_RNA|PI15_ENST00000523773.1_Splice_Site	NM_015886.3	NP_056970.1	O43692	PI15_HUMAN	peptidase inhibitor 15							extracellular region	peptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|skin(1)	30	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TTCCCTTCTAGGGGCAATTGG	0.393000													37	142					3.61848e-18	3.80755e-18	1	1	0
PROKR2	128674	broad.mit.edu	37	20	5294896	5294896	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:5294896A>G	ENST00000546004.1	-	2	366	c.120T>C	c.(118-120)gaT>gaC	p.D40D	PROKR2_ENST00000217270.3_Silent_p.D40D			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	40						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						TCATGTCCTCATCCTCATCCA	0.507000										HNSCC(71;0.22)			43	118					0	0	1	0	0
TTLL1	25809	broad.mit.edu	37	22	43460219	43460219	+	Silent	SNP	C	C	T	rs144960440		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:43460219C>T	ENST00000331018.7	-	6	855	c.615G>A	c.(613-615)acG>acA	p.T205T	TTLL1_ENST00000266254.7_Silent_p.T205T			O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	205	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		GTGGACGGTACGTGGACACCA	0.458000													15	70					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127765263	127765263	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:127765263C>G	ENST00000483725.3	-	6	2412	c.2076G>C	c.(2074-2076)ttG>ttC	p.L692F	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	692							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		CTTAAACCATCAATGCTTCGG	0.493000													14	44					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59797293	59797293	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:59797293A>G	ENST00000395125.1	+	12	1470	c.1447A>G	c.(1447-1449)Atg>Gtg	p.M483V	DAAM1_ENST00000351081.1_Missense_Mutation_p.M483V|DAAM1_ENST00000360909.3_Missense_Mutation_p.M483V	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	483					actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		GAAGGAAGAGATGATGCAGAC	0.423000													7	73					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47769663	47769663	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47769663T>C	ENST00000359568.5	+	8	1380	c.1273T>C	c.(1273-1275)Tcc>Ccc	p.S425P	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	425	Glu-rich.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGACCTGCAGTCCGAGCACGG	0.473000													6	146					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34302199	34302199	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:34302199G>A	ENST00000361162.6	-	11	1388	c.1004C>T	c.(1003-1005)gCt>gTt	p.A335V	RBM39_ENST00000528062.3_Missense_Mutation_p.A313V|RBM39_ENST00000407261.4_Missense_Mutation_p.A178V|RBM39_ENST00000253363.6_Missense_Mutation_p.A335V	NM_004902.3|NM_184234.2	NP_004893.1|NP_909122.1	Q14498	RBM39_HUMAN	RNA binding motif protein 39	335	Activating domain (By similarity).|Interaction with JUN (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					AAATGAACTAGCACTCGAAGC	0.418000													41	79					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65342171	65342171	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:65342171G>A	ENST00000402939.2	-	23	4270	c.4271C>T	c.(4270-4272)gCc>gTc	p.A1424V	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1453					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TCGGTGGCTGGCTCTGTCCTC	0.622000													30	120					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19753567	19753567	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:19753567T>A	ENST00000400113.3	-	2	244	c.140A>T	c.(139-141)gAc>gTc	p.D47V		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	47					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GTTGAAGGAGTCGTCCCCACC	0.562000													42	131					0	0	1	0	0
AGPAT6	137964	broad.mit.edu	37	8	41467252	41467252	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:41467252A>T	ENST00000396987.3	+	4	1241	c.314A>T	c.(313-315)gAc>gTc	p.D105V	RP11-360L9.8_ENST00000581909.1_RNA	NM_178819.3	NP_848934.1	Q86UL3	GPAT4_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 6	105					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			AAGGCTCTGGACAACACTCCA	0.438000													10	172					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99678261	99678261	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:99678261T>C	ENST00000394132.2	-	14	2115	c.1298A>G	c.(1297-1299)cAg>cGg	p.Q433R	TTC23_ENST00000558613.1_Missense_Mutation_p.Q433R|TTC23_ENST00000558663.1_Missense_Mutation_p.Q433R|TTC23_ENST00000394136.1_Missense_Mutation_p.Q433R|TTC23_ENST00000262074.4_Missense_Mutation_p.Q433R|TTC23_ENST00000394135.3_Missense_Mutation_p.Q433R			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	433							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			CAGGGTGTCCTGAGGGATGCT	0.612000													12	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179402611	179402611	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179402611T>C	ENST00000589042.1	-	355	99547	c.99323A>G	c.(99322-99324)aAg>aGg	p.K33108R	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K24043R|TTN_ENST00000342992.6_Missense_Mutation_p.K30540R|TTN-AS1_ENST00000450692.2_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K31467R|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K24168R|TTN_ENST00000342175.6_Missense_Mutation_p.K24235R|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000415561.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31467							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTAACATCCTTCATTTCTTT	0.398000													5	29					0	0	1	0	0
PTPN11	5781	broad.mit.edu	37	12	112919948	112919948	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112919948T>G	ENST00000351677.2	+	10	1361	c.1163T>G	c.(1162-1164)gTc>gGc	p.V388G	PTPN11_ENST00000392597.1_Missense_Mutation_p.V388G	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	388	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						GTTAGGAACGTCAAAGAAAGC	0.383000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				4	145					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2164521	2164521	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2164521G>A	ENST00000262304.4	-	11	2711	c.2503C>T	c.(2503-2505)Cgc>Tgc	p.R835C	PKD1_ENST00000423118.1_Missense_Mutation_p.R835C	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	835					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ACGTAGAGGCGGCCGTCGCGG	0.692000													11	19					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198531	20198531	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:20198531A>G	ENST00000400331.5	-	5	1761	c.1453T>C	c.(1453-1455)Ttt>Ctt	p.F485L	MACC1_ENST00000332878.4_Missense_Mutation_p.F485L|MACC1_ENST00000589011.1_Missense_Mutation_p.F485L	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	485					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						TGAACACAAAAATCAAACAAG	0.398000													32	87					0	0	1	0	0
MIER3	166968	broad.mit.edu	37	5	56219085	56219085	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:56219085T>C	ENST00000381226.3	-	13	1553	c.1538A>G	c.(1537-1539)cAc>cGc	p.H513R	MIER3_ENST00000381199.3_Missense_Mutation_p.H508R|MIER3_ENST00000381213.3_Missense_Mutation_p.H507R|MIER3_ENST00000409421.1_Missense_Mutation_p.H445R|SETD9_ENST00000541720.1_Intron			Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family member 3	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(2)|urinary_tract(1)	19		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		GTGATGTGTGTGATTTTCAAA	0.453000													4	98					0	0	1	0	0
SPESP1	246777	broad.mit.edu	37	15	69238372	69238372	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:69238372G>T	ENST00000310673.3	+	2	653	c.499G>T	c.(499-501)Gaa>Taa	p.E167*	NOX5_ENST00000260364.5_Intron|NOX5_ENST00000448182.3_Intron|SPESP1_ENST00000560188.1_3'UTR|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000455873.3_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	167					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						AGTTGTTACTGAATCATCTAC	0.448000													23	133					1.10513e-12	1.15186e-12	1	1	0
SEPN1	57190	broad.mit.edu	37	1	26136267	26136267	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:26136267C>T	ENST00000361547.2	+	7	1021	c.966C>T	c.(964-966)gaC>gaT	p.D322D	SEPN1_ENST00000374315.1_Silent_p.D288D|SEPN1_ENST00000354177.4_Silent_p.D288D	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	322						endoplasmic reticulum membrane|extracellular region	protein binding	p.D322D(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCAAAGACGCCACCCACG	0.632000													42	131					0	0	1	0	0
DYNLL2	140735	broad.mit.edu	37	17	56164482	56164482	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:56164482G>A	ENST00000240343.6	+	2	309	c.31G>A	c.(31-33)Gca>Aca	p.A11T		NM_080677.2	NP_542408.1	Q96FJ2	DYL2_HUMAN	dynein, light chain, LC8-type 2	11					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|microtubule-based process|transport	centrosome|cytosol|dynein complex|microtubule|myosin complex|plasma membrane	motor activity			lung(3)	3						GATCAAGAACGCAGACATGTC	0.502000													13	45					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101611293	101611293	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:101611293T>C	ENST00000370449.4	+	32	4656	c.4543T>C	c.(4543-4545)Tgc>Cgc	p.C1515R		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1515	ABC transporter 2.		C -> Y (in dbSNP:rs8187710).			apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GATTATAGAGTGCGGCAGCCC	0.413000													6	146					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467666	74467666	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:74467666A>G	ENST00000249842.3	+	2	824	c.467A>G	c.(466-468)aAc>aGc	p.N156S	ISLR_ENST00000395118.1_Missense_Mutation_p.N156S|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	156					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						CTCAACCACAACCGCTTGCAC	0.632000													19	46					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6077679	6077679	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:6077679T>C	ENST00000217289.4	-	8	1747	c.957_splice	c.e8-1	p.Y320_splice	FERMT1_ENST00000536936.1_Splice_Site_p.Y63_splice	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	320	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						GCTAATGTGGTACTAAAATGA	0.358000													26	235					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16326726	16326726	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:16326726T>C	ENST00000244769.4	-	8	2752	c.1816A>G	c.(1816-1818)Aac>Gac	p.N606D	ATXN1_ENST00000436367.1_Missense_Mutation_p.N606D	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	606	AXH.|Interaction with USP7.|RNA-binding.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TTCAGGTCGTTGCTTATCTCT	0.532000													7	113					0	0	1	0	0
CBX6	23466	broad.mit.edu	37	22	39262787	39262787	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:39262787T>C	ENST00000407418.3	-	5	789	c.666A>G	c.(664-666)acA>acG	p.T222T	CBX6_ENST00000216083.6_Silent_p.T204T			O95503	CBX6_HUMAN	chromobox homolog 6	222					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex				large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(58;0.04)					GGCGGATCTGTGTACGCAGGA	0.701000													22	105					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33944930	33944930	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:33944930C>A	ENST00000296589.4	-	7	1562	c.1416G>T	c.(1414-1416)aaG>aaT	p.K472N	SLC45A2_ENST00000342059.3_Missense_Mutation_p.K413N	NM_016180.3	NP_057264.3	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	472					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						AGTCCATGCCCTTCCCTCTCA	0.597000													9	33					5.4927e-09	5.66993e-09	1	1	0
TJAP1	93643	broad.mit.edu	37	6	43473043	43473043	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:43473043T>C	ENST00000372444.2	+	11	1527	c.1094T>C	c.(1093-1095)gTg>gCg	p.V365A	TJAP1_ENST00000483640.1_3'UTR|TJAP1_ENST00000438588.2_Missense_Mutation_p.V375A|TJAP1_ENST00000259751.1_Missense_Mutation_p.V365A|TJAP1_ENST00000372445.5_Missense_Mutation_p.V375A|TJAP1_ENST00000372449.1_Missense_Mutation_p.V375A|TJAP1_ENST00000372452.1_Missense_Mutation_p.V365A|TJAP1_ENST00000436109.2_Missense_Mutation_p.V365A	NM_001146018.1	NP_001139490.1	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 (peripheral)	375						Golgi apparatus|tight junction	protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|urinary_tract(2)	21	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			cccagcccagtgcccagcacc	0.687000													15	37					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30633512	30633512	+	Splice_Site	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30633512T>A	ENST00000376442.3	-	5	862		c.e5-2			NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16						mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CTCAGGGACCTGAGTTGGGAA	0.562000													22	67					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713872	30713872	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:30713872G>A	ENST00000295754.5	+	4	1579	c.1197G>A	c.(1195-1197)ggG>ggA	p.G399G	TGFBR2_ENST00000359013.4_Silent_p.G424G	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	399	Protein kinase.				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						GTGACTTTGGGCTTTCCCTGC	0.552000													7	401					0	0	1	0	0
ZNF641	121274	broad.mit.edu	37	12	48737414	48737414	+	Missense_Mutation	SNP	G	G	A	rs144784236	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:48737414G>A	ENST00000544117.2	-	6	1367	c.659C>T	c.(658-660)cCg>cTg	p.P220L	ZNF641_ENST00000301042.3_Missense_Mutation_p.P220L|ZNF641_ENST00000547026.1_Missense_Mutation_p.P206L|ZNF641_ENST00000448928.3_Missense_Mutation_p.P197L			Q96N77	ZN641_HUMAN	zinc finger protein 641	220	Transactivation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	12						ATCATGCTCCGGGTTCCAGAG	0.522000													25	26					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149769567	149769567	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:149769567A>G	ENST00000451292.1	+	20	3383	c.3275A>G	c.(3274-3276)cAg>cGg	p.Q1092R	TCOF1_ENST00000504761.2_Missense_Mutation_p.Q1055R|TCOF1_ENST00000439160.2_Missense_Mutation_p.Q1055R|TCOF1_ENST00000377797.3_Missense_Mutation_p.Q1055R|TCOF1_ENST00000445265.2_Missense_Mutation_p.Q978R|TCOF1_ENST00000323668.7_Missense_Mutation_p.Q978R|TCOF1_ENST00000513346.1_Missense_Mutation_p.Q1092R			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	1055					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCAAGAAACAGGAGGGACCA	0.597000													12	30					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635745	33635745	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:33635745T>C	ENST00000380099.3	+	4	2537	c.2529T>C	c.(2527-2529)agT>agC	p.S843S	KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	843	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACTCCCCCAGTCAGGTGGCGG	0.478000													5	137					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082725	152082725	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152082725A>T	ENST00000368804.1	-	2	2967	c.2968T>A	c.(2968-2970)Tac>Aac	p.Y990N		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	990	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tcctcgcggtattttttctcc	0.562000													9	216					0	0	1	0	0
ZNF610	162963	broad.mit.edu	37	19	52869218	52869218	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:52869218A>G	ENST00000601151.1	+	5	910	c.458A>G	c.(457-459)tAc>tGc	p.Y153C	ZNF610_ENST00000327920.8_Missense_Mutation_p.Y196C|ZNF610_ENST00000321287.8_Missense_Mutation_p.Y196C|ZNF610_ENST00000403906.3_Missense_Mutation_p.Y196C	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GAGAAAGCATACATTAGAGGA	0.328000													10	85					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237921019	237921019	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:237921019A>G	ENST00000366574.2	+	82	11585	c.11268A>G	c.(11266-11268)gcA>gcG	p.A3756A	RYR2_ENST00000360064.6_Silent_p.A3762A|RYR2_ENST00000542537.1_Silent_p.A3740A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3756					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAATGGTAGCAGCTACTCTGA	0.368000													16	74					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94797542	94797542	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:94797542A>G	ENST00000453321.3	+	12	1282	c.1224A>G	c.(1222-1224)caA>caG	p.Q408Q	TMEM67_ENST00000409623.3_Silent_p.Q327Q	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	408					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			ATCAACATCAATATATTTTGG	0.338000													5	239					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372644	74372644	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:74372644A>G	ENST00000429810.2	-	0	1552																											TACCCTTGTCAGGGGGAACAA	0.443000													6	55					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87679894	87679894	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:87679894T>C	ENST00000436978.1	+	22	3857	c.3377T>C	c.(3376-3378)gTt>gCt	p.V1126A	PTPN13_ENST00000511467.1_Missense_Mutation_p.V1126A|PTPN13_ENST00000316707.6_Missense_Mutation_p.V935A|PTPN13_ENST00000411767.2_Missense_Mutation_p.V1126A|PTPN13_ENST00000427191.2_Missense_Mutation_p.V1107A	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1126	PDZ 1.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ATCAGTTCAGTTGCCCCTGGA	0.378000													34	107					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228475447	228475447	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:228475447T>C	ENST00000570156.2	+	41	10958	c.10884T>C	c.(10882-10884)ggT>ggC	p.G3628G	OBSCN_ENST00000366707.4_Silent_p.G318G|OBSCN_ENST00000284548.11_Silent_p.G3199G|OBSCN_ENST00000359599.6_Silent_p.G2046G|OBSCN_ENST00000422127.1_Silent_p.G3199G|OBSCN_ENST00000366709.4_Silent_p.G318G	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2661	Ig-like 37.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGCTGGAGGGTGGTGCTGCCA	0.627000													13	52					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204309667	204309667	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:204309667A>G	ENST00000319170.5	-	13	1999	c.1700T>C	c.(1699-1701)gTc>gCc	p.V567A	RAPH1_ENST00000457812.1_Missense_Mutation_p.V567A|RAPH1_ENST00000453034.1_Missense_Mutation_p.V619A|RAPH1_ENST00000439222.1_Missense_Mutation_p.V592A|RAPH1_ENST00000419464.1_Missense_Mutation_p.V567A|RAPH1_ENST00000374488.2_Missense_Mutation_p.V592A|RAPH1_ENST00000374493.3_Missense_Mutation_p.V619A|RAPH1_ENST00000418114.1_Missense_Mutation_p.V567A|RAPH1_ENST00000308091.4_Missense_Mutation_p.V619A|RAPH1_ENST00000423104.1_Missense_Mutation_p.V594A|RAPH1_ENST00000374489.2_Missense_Mutation_p.V594A	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	567					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTGGGAACGGACGTGTCCTGC	0.443000													35	113					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45401114	45401114	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:45401114T>C	ENST00000389039.6	-	12	1656	c.1271A>G	c.(1270-1272)gAc>gGc	p.D424G	DUOX2_ENST00000603300.1_Missense_Mutation_p.D424G			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	424	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GGCCACATAGTCTGTACGGGA	0.562000													20	51					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64109585	64109585	+	Silent	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64109585T>A	ENST00000356786.5	+	8	839	c.795T>A	c.(793-795)gcT>gcA	p.A265A	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	265					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ACGCCAAGGCTCAGCTGCGGC	0.677000													10	17					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95508100	95508100	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:95508100T>C	ENST00000297591.5	-	19	4478	c.4403A>G	c.(4402-4404)gAc>gGc	p.D1468G	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1468					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ATCCAGATTGTCATCATCTTT	0.408000													28	93					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52416439	52416439	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52416439C>A	ENST00000420323.2	+	50	8170	c.7909C>A	c.(7909-7911)Cta>Ata	p.L2637I		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2637	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCTACAGAACCTACCCATCAC	0.577000													8	274					3.09899e-07	3.1815e-07	1	1	0
CEP170B	283638	broad.mit.edu	37	14	105353441	105353441	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:105353441C>T	ENST00000453495.1	+	12	3096	c.2868C>T	c.(2866-2868)gaC>gaT	p.D956D	CEP170B_ENST00000418279.1_Silent_p.D885D|CEP170B_ENST00000414716.3_Silent_p.D955D|CEP170B_ENST00000556508.1_Silent_p.D885D					centrosomal protein 170B																		GGGACTCGGACGTGGACACAG	0.692000													18	73					0	0	1	0	0
SPATA7	55812	broad.mit.edu	37	14	88904243	88904243	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:88904243A>G	ENST00000556553.1	+	12	1740	c.1181A>G	c.(1180-1182)aAc>aGc	p.N394S	SPATA7_ENST00000045347.7_Missense_Mutation_p.N426S|SPATA7_ENST00000393545.4_Missense_Mutation_p.N426S|SPATA7_ENST00000356583.5_Missense_Mutation_p.N394S			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	426					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						TCGGAGGAAAACTCGGTAAAG	0.348000													6	94					0	0	1	0	0
KANK3	256949	broad.mit.edu	37	19	8389336	8389336	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:8389336G>T	ENST00000330915.3	-	10	2444	c.2379C>A	c.(2377-2379)acC>acA	p.T793T	KANK3_ENST00000593649.1_Silent_p.T793T	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	793										breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						TGCTCACCTGGGTGTCGGGCT	0.587000													7	11					2.0095e-06	2.05926e-06	1	1	0
RHBDF1	64285	broad.mit.edu	37	16	108407	108407	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:108407A>G	ENST00000262316.6	-	18	2642	c.2500T>C	c.(2500-2502)Ttc>Ctc	p.F834L		NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	834					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				CAGGTGAGGAACTCACACCAC	0.592000													16	214					0	0	1	0	0
GLE1	2733	broad.mit.edu	37	9	131287588	131287588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131287588C>T	ENST00000309971.4	+	7	1121	c.1015C>T	c.(1015-1017)Cag>Tag	p.Q339*	GLE1_ENST00000539582.1_Nonsense_Mutation_p.Q85*|GLE1_ENST00000372770.4_Nonsense_Mutation_p.Q339*|GLE1_ENST00000494417.1_3'UTR	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	339					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						CAAGAGGAGGCAGGATGAAGA	0.612000													8	46					0	0	1	0	0
AGBL4	84871	broad.mit.edu	37	1	49056597	49056597	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:49056597T>C	ENST00000371839.1	-	10	1128	c.1012A>G	c.(1012-1014)Atg>Gtg	p.M338V	AGBL4_ENST00000334103.7_Missense_Mutation_p.M71V	NM_032785.3	NP_116174.3	Q5VU57	CBPC6_HUMAN	ATP/GTP binding protein-like 4	338					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		TTGCCATACATGAAGCCATTC	0.463000													3	17					0	0	1	0	0
SFXN1	94081	broad.mit.edu	37	5	174940534	174940534	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:174940534C>T	ENST00000321442.5	+	7	919	c.665C>T	c.(664-666)gCg>gTg	p.A222V		NM_022754.5	NP_073591.2	Q9H9B4	SFXN1_HUMAN	sideroflexin 1	222					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity|protein binding			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(3)	15	all_cancers(89;0.00922)|Renal(175;0.000269)|Lung NSC(126;0.00515)|all_lung(126;0.00873)	Medulloblastoma(196;0.0399)|all_neural(177;0.0663)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCGAACGCTGCGAAACAAGCC	0.517000													11	57					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209817	140209817	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140209817C>T	ENST00000529310.1	+	1	2255	c.2141C>T	c.(2140-2142)aCg>aTg	p.T714M	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.T714M(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTCCTCACGCTACTGCTG	0.706000													5	176					0	0	1	0	0
TAF7	6879	broad.mit.edu	37	5	140698689	140698689	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140698689T>A	ENST00000313368.5	-	1	1641	c.923A>T	c.(922-924)aAa>aTa	p.K308I		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	308					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTTCCACTTTCATGATGAG	0.453000													3	29					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184038716	184038716	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:184038716C>T	ENST00000342981.4	+	8	1046	c.630_splice	c.e8-1	p.T211_splice	EIF4G1_ENST00000382330.3_Splice_Site_p.T218_splice|EIF4G1_ENST00000435046.2_Splice_Site_p.T15_splice|EIF4G1_ENST00000411531.1_Splice_Site_p.T171_splice|EIF4G1_ENST00000346169.2_Splice_Site_p.T211_splice|EIF4G1_ENST00000392537.2_Splice_Site_p.T124_splice|EIF4G1_ENST00000352767.3_Splice_Site_p.T218_splice|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000424196.1_Splice_Site_p.T218_splice|EIF4G1_ENST00000434061.2_Splice_Site_p.T15_splice|EIF4G1_ENST00000441154.1_Splice_Site_p.T47_splice|EIF4G1_ENST00000427845.1_Splice_Site_p.T124_splice|EIF4G1_ENST00000319274.6_Splice_Site_p.T211_splice|EIF4G1_ENST00000350481.5_Splice_Site_p.T47_splice|EIF4G1_ENST00000414031.1_Splice_Site_p.T171_splice	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	211					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTCCTGCAGACGGGAGGCGGT	0.532000													13	32					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67381419	67381419	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67381419G>A	ENST00000329956.6	+	4	432	c.413G>A	c.(412-414)gGt>gAt	p.G138D	LRRC36_ENST00000290940.7_5'UTR|LRRC36_ENST00000541146.1_5'UTR|LRRC36_ENST00000563189.1_Missense_Mutation_p.G17D|LRRC36_ENST00000563303.1_3'UTR|LRRC36_ENST00000435835.3_Missense_Mutation_p.G17D	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	138	LRRCT.									endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GTACGTGAAGGTGAGAGAAAA	0.368000													4	81					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33139529	33139529	+	Silent	SNP	C	C	T	rs146093235	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:33139529C>T	ENST00000341947.2	-	42	3338	c.3111G>A	c.(3109-3111)ccG>ccA	p.P1037P	COL11A2_ENST00000374708.4_Silent_p.P951P|COL11A2_ENST00000374712.1_Silent_p.P956P|COL11A2_ENST00000395197.1_Silent_p.P977P|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000357486.1_Silent_p.P1016P|COL11A2_ENST00000361917.1_Silent_p.P930P|COL11A2_ENST00000374714.1_Silent_p.P1011P|COL11A2_ENST00000374713.1_Silent_p.P990P	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1037	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GGGGACCCTGCGGGCCTGGGC	0.657000													16	35					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109793467	109793467	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109793467G>A	ENST00000271332.3	+	1	827	c.766G>A	c.(766-768)Gtc>Atc	p.V256I		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	256	Cadherin 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GAGCACCCACGTCTTCAGGGT	0.582000													33	67					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146247394	146247394	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:146247394T>C	ENST00000367503.3	-	16	3665	c.3267A>G	c.(3265-3267)atA>atG	p.I1089M	SHPRH_ENST00000367505.2_Missense_Mutation_p.I1080M|SHPRH_ENST00000275233.7_Missense_Mutation_p.I1080M|SHPRH_ENST00000438092.2_Missense_Mutation_p.I1089M	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1080					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGTGCCTGGCTATCAACAATT	0.388000													29	96					0	0	1	0	0
PRSS27	83886	broad.mit.edu	37	16	2765775	2765775	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2765775G>A	ENST00000302641.3	-	3	234	c.180C>T	c.(178-180)tgC>tgT	p.C60C		NM_031948.3	NP_114154.1	Q9BQR3	PRS27_HUMAN	protease, serine 27	60	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	8						GGCTGCCCCCGCAGAAGTGGC	0.697000													4	19					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124359353	124359353	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:124359353T>C	ENST00000287394.5	-	16	2298	c.2191A>G	c.(2191-2193)Aca>Gca	p.T731A	ATAD2_ENST00000521903.1_Missense_Mutation_p.T49A	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	731					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTTTTATTTGTTCTGAATTCT	0.353000													16	95					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45689927	45689927	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:45689927G>A	ENST00000322157.4	+	18	2434	c.2197G>A	c.(2197-2199)Gtg>Atg	p.V733M	RP11-580I16.2_ENST00000582389.1_RNA|RP11-580I16.2_ENST00000582066.1_RNA|NPEPPS_ENST00000530173.1_Missense_Mutation_p.V729M|NPEPPS_ENST00000544660.1_Missense_Mutation_p.V653M	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	733					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TAAGGACCACGTGGAAGGAAA	0.458000													22	52					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137666820	137666820	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:137666820G>T	ENST00000323760.6	-	2	328	c.50C>A	c.(49-51)tCa>tAa	p.S17*	CDC25C_ENST00000415130.2_Nonsense_Mutation_p.S17*|CDC25C_ENST00000357274.3_Nonsense_Mutation_p.S17*|CDC25C_ENST00000356505.3_Nonsense_Mutation_p.S17*|CDC25C_ENST00000348983.3_Nonsense_Mutation_p.S17*|CDC25C_ENST00000514555.1_Nonsense_Mutation_p.S17*|CDC25C_ENST00000513970.1_Nonsense_Mutation_p.S17*	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	17					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACTGGGTCCTGAGCCAGAGCT	0.463000													41	78					1.48646e-12	1.5486e-12	1	1	0
SLC52A2	79581	broad.mit.edu	37	8	145584251	145584251	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145584251T>C	ENST00000532887.1	+	4	1586	c.1001_splice	c.e4-1	p.S335_splice	SLC52A2_ENST00000329994.2_Splice_Site_p.S335_splice|SLC52A2_ENST00000540505.1_Splice_Site_p.S247_splice|SLC52A2_ENST00000527078.1_Splice_Site_p.S335_splice|SLC52A2_ENST00000402965.1_Splice_Site_p.S335_splice|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Splice_Site_p.S335_splice			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	335						integral to plasma membrane	receptor activity|riboflavin transporter activity										TCACTGCAGGTCCTTGGCAGG	0.687000													45	141					0	0	1	0	0
TBC1D29	26083	broad.mit.edu	37	17	28890430	28890430	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:28890430G>T	ENST00000580161.1	+	6	2937	c.440G>T	c.(439-441)aGg>aTg	p.R147M	TBC1D29_ENST00000584297.1_3'UTR|TBC1D29_ENST00000579181.1_Missense_Mutation_p.R147M			Q9UFV1	TBC29_HUMAN	TBC1 domain family, member 29	147						intracellular	Rab GTPase activator activity			breast(1)|kidney(1)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Myeloproliferative disorder(56;0.0255)				agatgtggcaggataataggg	0.483000													6	18					0.00116845	0.00118101	1	1	0
TAF9	6880	broad.mit.edu	37	5	68662584	68662584	+	Translation_Start_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:68662584T>C	ENST00000506736.1	-	0	64				TAF9_ENST00000380818.3_Intron|TAF9_ENST00000502819.1_Intron|TAF9_ENST00000380822.4_Intron|TAF9_ENST00000217893.5_Intron|TAF9_ENST00000328663.4_Intron|TAF9_ENST00000512561.1_Intron			Q9Y3D8	KAD6_HUMAN	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa							Cajal body	adenylate kinase activity|ATP binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	8		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		TTAGCAATCATATGTAAAAtt	0.433000													4	4					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94496004	94496004	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:94496004G>T	ENST00000370225.3	-	29	4418	c.4332C>A	c.(4330-4332)tgC>tgA	p.C1444*		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1444					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTTCCTTCAGGCAGCGGTTGC	0.567000													5	85					0.00116845	0.00118101	1	1	0
C10orf71	118461	broad.mit.edu	37	10	50531538	50531538	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:50531538T>C	ENST00000374144.3	+	3	1236	c.948T>C	c.(946-948)tgT>tgC	p.C316C	C10orf71_ENST00000323868.4_Silent_p.C316C			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	316										endometrium(1)	1						GAGAACCCTGTCCTCCTGAGC	0.572000													4	44					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71053559	71053559	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:71053559A>G	ENST00000452400.2	-	14	3069	c.2888T>C	c.(2887-2889)gTc>gCc	p.V963A	NCOA2_ENST00000267974.4_Missense_Mutation_p.V51A	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	963					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AGCACAGGTGACTCTCACAGC	0.562000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								13	54					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327925	104327925	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:104327925C>T	ENST00000299767.5	+	5	785	c.603C>T	c.(601-603)tcC>tcT	p.S201S		NM_003299.1	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	201					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	GTTTCTATTCCGCCTTCCTTG	0.423000													18	100					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003904	122003904	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:122003904C>G	ENST00000498619.1	+	7	3571	c.3133C>G	c.(3133-3135)Cct>Gct	p.P1045A	CASR_ENST00000296154.5_Missense_Mutation_p.P1035A|CASR_ENST00000490131.1_Missense_Mutation_p.P1035A	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	1035					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCTGCAAGGACCTGTGGGTGG	0.577000													28	85					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	619641	619641	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:619641T>C	ENST00000588649.2	-	13	3095	c.3011A>G	c.(3010-3012)tAt>tGt	p.Y1004C		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	1004	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCCCGCCATAGCGCGTGAC	0.647000													66	163					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142627452	142627452	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:142627452C>T	ENST00000265310.1	-	2	566	c.218G>A	c.(217-219)cGa>cAa	p.R73Q	TRPV5_ENST00000442623.1_Missense_Mutation_p.R73Q	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	73					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					ACCTCTTTGTCGAACGTCACA	0.512000													29	94					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147381	54147381	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:54147381C>T	ENST00000265572.3	-	3	845	c.548G>A	c.(547-549)tGg>tAg	p.W183*	OPRK1_ENST00000520287.1_Nonsense_Mutation_p.W183*|OPRK1_ENST00000524278.1_Nonsense_Mutation_p.W94*|RP11-162D9.3_ENST00000524425.1_RNA	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	183					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CGACAGCAGCCAGATGCAGAT	0.493000													26	127					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20796591	20796591	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:20796591G>T	ENST00000328879.4	-	7	1830	c.1674C>A	c.(1672-1674)agC>agA	p.S558R	KLHL22_ENST00000440659.2_Missense_Mutation_p.S415R	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	558					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGCCTGTGCGGCTGCCGCGGT	0.612000													18	54					0.00121646	0.00122927	1	1	0
MYCN	4613	broad.mit.edu	37	2	16082735	16082735	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:16082735C>T	ENST00000281043.3	+	2	846	c.549C>T	c.(547-549)gcC>gcT	p.A183A		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	183					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CCCACCCGGCCGCCGAGTGCG	0.831000			A		neuroblastoma								4	3					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645592	13645592	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:13645592A>G	ENST00000361205.4	+	7	1525	c.857A>G	c.(856-858)aAc>aGc	p.N286S	LDLRAD4_ENST00000592991.1_Missense_Mutation_p.N188S|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000587757.1_Missense_Mutation_p.N249S|LDLRAD4_ENST00000586765.1_Missense_Mutation_p.N231S|LDLRAD4_ENST00000585931.1_Missense_Mutation_p.N209S|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.N286S|LDLRAD4_ENST00000399848.3_Missense_Mutation_p.N268S	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		TTTCAGCAGAACAATGCAGAG	0.547000													24	57					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40366395	40366395	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40366395G>A	ENST00000221347.6	-	30	13846	c.13839C>T	c.(13837-13839)tgC>tgT	p.C4613C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4613	VWFD 11.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGTAGTTCCCGCATAAGCCAC	0.677000													41	114					0	0	1	0	0
KIAA0930	23313	broad.mit.edu	37	22	45601193	45601193	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:45601193A>G	ENST00000336156.4	-	5	486	c.421T>C	c.(421-423)Ttc>Ctc	p.F141L	KIAA0930_ENST00000251993.7_Missense_Mutation_p.F146L|KIAA0930_ENST00000391627.2_Missense_Mutation_p.F107L|KIAA0930_ENST00000443310.3_Missense_Mutation_p.F123L	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930	141							protein binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						GGGGACGCGAACACTTGCTGG	0.582000													4	75					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262345	15262345	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:15262345T>C	ENST00000256953.2	-	5	635	c.299A>G	c.(298-300)aAc>aGc	p.N100S	RERG_ENST00000546331.1_Missense_Mutation_p.N81S|RERG_ENST00000536465.1_Missense_Mutation_p.N100S|RERG_ENST00000538313.1_Missense_Mutation_p.N100S	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	100					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ATCTAGGATGTTCTTAAGTGG	0.493000													113	454					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106497991	106497991	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:106497991G>A	ENST00000233154.4	+	4	876	c.434G>A	c.(433-435)aGc>aAc	p.S145N	NCK2_ENST00000522586.1_Intron|NCK2_ENST00000393349.2_Missense_Mutation_p.S145N|NCK2_ENST00000451463.2_Intron	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	145	SH3 2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						GAGAAGTGCAGCGACGGTTGG	0.642000													24	58					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242174626	242174626	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:242174626G>A	ENST00000391975.1	-	23	3281	c.3054C>T	c.(3052-3054)atC>atT	p.I1018I	HDLBP_ENST00000310931.4_Silent_p.I1018I|HDLBP_ENST00000391976.2_Silent_p.I1018I|HDLBP_ENST00000427183.2_Silent_p.I985I	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1018	KH 12.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CCGTGATGGCGATGATGTCAG	0.597000													4	133					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244391	56244391	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56244391G>A	ENST00000332836.2	-	2	833	c.806C>T	c.(805-807)tCc>tTc	p.S269F		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	269	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAGGAGAGAGGATTCTGGAAG	0.408000													11	69					0	0	1	0	0
NAT8	9027	broad.mit.edu	37	2	73868455	73868455	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:73868455A>G	ENST00000272425.3	-	2	450	c.301T>C	c.(301-303)Tac>Cac	p.Y101H		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	101	N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						TCACTCAGGTAGGATTTGGTA	0.537000													36	162					0	0	1	0	0
PAK1	5058	broad.mit.edu	37	11	77048409	77048409	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:77048409A>G	ENST00000356341.3	-	12	1707	c.1176T>C	c.(1174-1176)agT>agC	p.S392S	PAK1_ENST00000528203.1_Silent_p.S294S|PAK1_ENST00000525542.1_5'UTR|PAK1_ENST00000530617.1_Silent_p.S392S|PAK1_ENST00000278568.4_Silent_p.S392S	NM_002576.4	NP_002567.3	Q13153	PAK1_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	392	Protein kinase.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(13)|skin(2)|stomach(1)	29	all_cancers(14;1.75e-18)					GAATATTGTCACTCTTGATGT	0.478000													7	22					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28127463	28127463	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:28127463C>G	ENST00000316334.3	-	8	1789	c.1660G>C	c.(1660-1662)Gag>Cag	p.E554Q		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	554	PDZ 3.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		ATCTGGACCTCAAGTGCTTTA	0.502000													35	79					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28369194	28369194	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:28369194A>T	ENST00000261609.7	-	85	13285	c.13177T>A	c.(13177-13179)Tcc>Acc	p.S4393T		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4393					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTTCCCTGGGATATCAGAATT	0.498000											OREG0022996	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	67					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46316747	46316747	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:46316747G>A	ENST00000465950.1	-	3	4361	c.3152C>T	c.(3151-3153)gCc>gTc	p.A1051V	SCAF11_ENST00000369367.3_Missense_Mutation_p.A1366V|SCAF11_ENST00000550629.1_5'UTR|SCAF11_ENST00000549162.1_Missense_Mutation_p.A1174V|SCAF11_ENST00000419565.2_Missense_Mutation_p.A1366V			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1366					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						ATCTGCGCTGGCTTCCACTGC	0.408000													25	208					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19373150	19373150	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:19373150T>C	ENST00000263208.5	-	12	1479	c.1223A>G	c.(1222-1224)cAg>cGg	p.Q408R	HIRA_ENST00000340170.4_Missense_Mutation_p.Q408R|HIRA_ENST00000546308.1_Missense_Mutation_p.Q364R|HIRA_ENST00000541063.1_Missense_Mutation_p.Q364R	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	408	Poly-Gln.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					CTGCTGCTGCTGCCTTCGCTG	0.587000													17	48					0	0	1	0	0
POP1	10940	broad.mit.edu	37	8	99158845	99158845	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:99158845T>C	ENST00000401707.2	+	12	1725	c.1644T>C	c.(1642-1644)tgT>tgC	p.C548C	POP1_ENST00000349693.3_Silent_p.C548C	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	548					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CTGTGGAATGTACGCATAGCT	0.398000													59	171					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029986	32029986	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32029986G>A	ENST00000375244.3	-	20	7317	c.7116C>T	c.(7114-7116)taC>taT	p.Y2372Y	TNXB_ENST00000375247.2_Silent_p.Y2372Y			P22105	TENX_HUMAN	tenascin XB	2434	Fibronectin type-III 16.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGTGGAAGCCGTACAGGTTCA	0.642000													13	52					0	0	1	0	0
FABP1	2168	broad.mit.edu	37	2	88422623	88422623	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:88422623T>C	ENST00000295834.3	-	4	432	c.333_splice	c.e4-1	p.T112_splice	FABP1_ENST00000495375.1_5'UTR|FABP1_ENST00000393750.3_3'UTR	NM_001443.2	NP_001434.1	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	112					organ morphogenesis					kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	6						AATGTCATGGTCTGAAAGCCA	0.284000													20	50					0	0	1	0	0
ATP5G3	518	broad.mit.edu	37	2	176043862	176043862	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:176043862A>G	ENST00000284727.4	-	4	3261	c.237T>C	c.(235-237)ggT>ggC	p.G79G	ATP5G3_ENST00000409194.1_Silent_p.G79G|ATP5G3_ENST00000392541.3_Silent_p.G79G	NM_001002258.4|NM_001689.4	NP_001002258.1|NP_001680.1	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	79					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CTGTTGCAGCACCTGCACCAA	0.463000													10	61					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678670	100678670	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100678670A>G	ENST00000306151.4	+	3	4037	c.3973A>G	c.(3973-3975)Acc>Gcc	p.T1325A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1325	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCTGAAGGTACCAGCATGCC	0.463000													15	669					0	0	1	0	0
WAC	51322	broad.mit.edu	37	10	28824585	28824585	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:28824585T>C	ENST00000375664.3	+	3	647	c.38T>C	c.(37-39)aTg>aCg	p.M13T	WAC_ENST00000375646.1_Missense_Mutation_p.M13T|WAC_ENST00000428935.1_Missense_Mutation_p.M13T|WAC_ENST00000347934.4_Missense_Mutation_p.M58T|WAC_ENST00000354911.4_Missense_Mutation_p.M58T|WAC_ENST00000532233.1_3'UTR			Q9BTA9	WAC_HUMAN	WW domain containing adaptor with coiled-coil	58					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|urinary_tract(1)	32						CCAAATAAAATGTTGCGGAGA	0.453000													29	77					0	0	1	0	0
RAD23B	5887	broad.mit.edu	37	9	110087223	110087223	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:110087223G>A	ENST00000358015.3	+	9	1405	c.1054G>A	c.(1054-1056)Gct>Act	p.A352T	RAD23B_ENST00000416373.2_Missense_Mutation_p.A280T	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	352					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						AATTGCAGAAGCTGGAAGTGG	0.408000								Direct reversal of damage;Nucleotide excision repair (NER)					6	69					0	0	1	0	0
FAM69B	138311	broad.mit.edu	37	9	139617613	139617613	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139617613T>C	ENST00000371691.1	+	3	1521	c.422T>C	c.(421-423)cTc>cCc	p.L141P	SNHG7_ENST00000414282.1_RNA|FAM69B_ENST00000371692.4_Missense_Mutation_p.L228P			Q5VUD6	FA69B_HUMAN	family with sequence similarity 69, member B	228						endoplasmic reticulum membrane|integral to membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(1)|prostate(1)	8	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		TGTGGGGACCTCTACCTCACC	0.687000													45	117					0	0	1	0	0
PICALM	8301	broad.mit.edu	37	11	85701438	85701438	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:85701438A>G	ENST00000393346.3	-	13	1411	c.1263T>C	c.(1261-1263)ccT>ccC	p.P421P	PICALM_ENST00000528398.1_Intron|PICALM_ENST00000526033.1_Intron|PICALM_ENST00000356360.5_Silent_p.P421P|PICALM_ENST00000532317.1_Intron			Q13492	PICAL_HUMAN	phosphatidylinositol binding clathrin assembly protein	421					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				TAGCAGAGAAAGGATCTGTGC	0.343000			T	"""MLLT10, MLL"""	"""TALL, AML, """								22	54					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839216	128839216	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:128839216T>C	ENST00000310343.9	-	22	5849	c.5850A>G	c.(5848-5850)cgA>cgG	p.R1950R	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Silent_p.R1601R|ARHGAP32_ENST00000392657.3_Silent_p.R1601R	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1950	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TAACCCAGGGTCGCTCCATCT	0.512000													8	151					0	0	1	0	0
ZNF75A	7627	broad.mit.edu	37	16	3367268	3367268	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3367268T>C	ENST00000574298.1	+	6	763	c.290T>C	c.(289-291)gTc>gCc	p.V97A	ZNF75A_ENST00000498240.2_3'UTR	NM_153028.2	NP_694573.1	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(7)|prostate(1)	12						TCAGCAGGCGTCATATCAAAA	0.388000													8	110					0	0	1	0	0
CLPX	10845	broad.mit.edu	37	15	65449183	65449183	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:65449183T>C	ENST00000300107.3	-	9	1333	c.1146_splice	c.e9+1	p.Q382_splice		NM_006660.3	NP_006651.2	O76031	CLPX_HUMAN	caseinolytic mitochondrial matrix peptidase chaperone subunit	382					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)|skin(2)	16						ACTGCTTACTTGCTGAACGCC	0.393000													5	61					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112622580	112622580	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112622580C>T	ENST00000550722.1	-	61	10147	c.9752G>A	c.(9751-9753)cGc>cAc	p.R3251H	HECTD4_ENST00000430131.2_Missense_Mutation_p.R2975H|HECTD4_ENST00000377560.5_Missense_Mutation_p.R3225H	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CACCAGCAAGCGGCTGTGGGC	0.697000													54	206					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739318	55739318	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:55739318A>G	ENST00000370830.3	-	1	1044	c.346T>C	c.(346-348)Tac>Cac	p.Y116H	BMP5_ENST00000446683.2_Missense_Mutation_p.Y116H	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	116					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GAGGCTGGGTATCCCTTTCTT	0.522000													9	132					0	0	1	0	0
ABHD11	83451	broad.mit.edu	37	7	73151274	73151274	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:73151274T>C	ENST00000222800.3	-	5	869	c.800A>G	c.(799-801)aAc>aGc	p.N267S	ABHD11_ENST00000458339.1_Intron|ABHD11_ENST00000395147.4_Missense_Mutation_p.N210S|ABHD11_ENST00000437775.2_Missense_Mutation_p.N260S	NM_148912.2	NP_683710.1	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11	267							hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Lung NSC(55;0.0908)|all_lung(88;0.198)				GAACTGGGAGTTTCCACCAAG	0.592000													4	257					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20854395	20854395	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:20854395T>C	ENST00000381552.1	+	3	639		c.e3+2		SLCO1C1_ENST00000545604.1_Splice_Site|SLCO1C1_ENST00000540354.1_Splice_Site|SLCO1C1_ENST00000266509.2_Splice_Site|SLCO1C1_ENST00000545102.1_Intron			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TTGAAATTGGTAGGTATTACA	0.418000													30	135					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25312960	25312960	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:25312960A>G	ENST00000549804.2	+	0	538				SNHG14_ENST00000551077.1_RNA|SNORD116-7_ENST00000384404.1_RNA																							CCCCCATAAAAACATTCCTTG	0.498000													9	148					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27941035	27941035	+	Silent	SNP	T	T	C	rs143532619		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:27941035T>C	ENST00000374005.3	-	11	1443	c.1155A>G	c.(1153-1155)gcA>gcG	p.A385A	FGR_ENST00000374004.1_Silent_p.A385A|FGR_ENST00000545953.1_Silent_p.A319A|FGR_ENST00000399173.1_Silent_p.A385A	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	385	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGATGTTGGCTGCCCTCAGGT	0.592000													4	19					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109814242	109814242	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109814242C>A	ENST00000271332.3	+	28	7885	c.7824C>A	c.(7822-7824)tcC>tcA	p.S2608S	CELSR2_ENST00000498157.1_3'UTR	NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2608					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCTTCCTCTCCTATGTGGTGC	0.612000													5	155					0.184627	0.184914	1	1	0
BID	637	broad.mit.edu	37	22	18226677	18226677	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:18226677C>T	ENST00000317361.7	-	3	579	c.253G>A	c.(253-255)Gca>Aca	p.A85T	BID_ENST00000399767.1_5'UTR|BID_ENST00000399765.1_Intron|BID_ENST00000399774.3_Missense_Mutation_p.A39T|BID_ENST00000473439.1_5'UTR|BID_ENST00000342111.5_Missense_Mutation_p.A39T|BID_ENST00000551952.1_Missense_Mutation_p.A39T	NM_197966.2	NP_932070.1	P55957	BID_HUMAN	BH3 interacting domain death agonist	39					activation of pro-apoptotic gene products|establishment of protein localization in membrane|induction of apoptosis by intracellular signals|induction of apoptosis via death domain receptors|neuron apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|release of cytochrome c from mitochondria	cytosol|membrane fraction|mitochondrial outer membrane	death receptor binding			large_intestine(2)|ovary(1)	3		all_epithelial(15;0.198)		Lung(27;0.0419)		TGGCCCAGTGCGTCCAGCTCT	0.587000													37	94					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136806	80136806	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:80136806C>T	ENST00000466387.1	+	11	1663	c.939C>T	c.(937-939)ggC>ggT	p.G313G	CTNNA2_ENST00000541047.1_Silent_p.G313G|CTNNA2_ENST00000496558.1_Silent_p.G313G|CTNNA2_ENST00000540488.1_Silent_p.G313G|CTNNA2_ENST00000361291.4_Silent_p.G347G|CTNNA2_ENST00000402739.4_Silent_p.G313G			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	313					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TCATCAGCGGCGCAGCGCTGA	0.637000													39	120					0	0	1	0	0
DBX1	120237	broad.mit.edu	37	11	20181531	20181531	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:20181531C>T	ENST00000524983.2	-	1	628	c.340G>A	c.(340-342)Gcc>Acc	p.A114T	DBX1_ENST00000227256.3_Missense_Mutation_p.A114T			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	114					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						GAGAGGATGGCGTTCACTCCA	0.647000													12	25					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1574554	1574554	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:1574554T>C	ENST00000426508.2	-	24	3503	c.3141_splice	c.e24+1	p.K1047_splice	IFT140_ENST00000361339.5_Splice_Site_p.K241_splice	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	1047										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CCGTGGTACCTTGCACAGGCG	0.632000													25	53					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34818098	34818098	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:34818098T>A	ENST00000360581.1	+	3	433	c.305T>A	c.(304-306)aTc>aAc	p.I102N	NPSR1_ENST00000381553.3_Missense_Mutation_p.I102N|NPSR1_ENST00000381539.3_Missense_Mutation_p.I102N|NPSR1_ENST00000381542.1_Intron|NPSR1_ENST00000531252.1_Intron|NPSR1_ENST00000359791.1_Missense_Mutation_p.I102N	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	102						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CTGGTCAACATCTTGACAGAT	0.403000													11	43					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113729502	113729502	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:113729502C>T	ENST00000397030.1	+	11	1443	c.1407_splice	c.e11+1	p.T469_splice	MCF2L_ENST00000434480.2_Splice_Site_p.T442_splice|MCF2L_ENST00000375601.3_Splice_Site_p.T440_splice|MCF2L_ENST00000375608.3_Splice_Site_p.T466_splice|MCF2L_ENST00000375604.2_Splice_Site_p.T493_splice|MCF2L_ENST00000442652.2_Splice_Site_p.T466_splice|MCF2L_ENST00000423482.2_Splice_Site_p.T434_splice|MCF2L_ENST00000421756.1_Splice_Site_p.T440_splice|MCF2L_ENST00000375597.4_Splice_Site_p.T434_splice|MCF2L_ENST00000535094.2_Splice_Site_p.T436_splice			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	466					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGCCTGGAGACGGTAGGCCGA	0.687000													4	29					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11581241	11581241	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:11581241G>A	ENST00000423059.3	-	6	1878	c.1627C>T	c.(1627-1629)Cgg>Tgg	p.R543W		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	543	TSP type-1 5.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GTAATGCGCCGCTTCCTCAGT	0.448000										HNSCC(18;0.044)			9	35					0	0	1	0	0
TMEM65	157378	broad.mit.edu	37	8	125334372	125334372	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:125334372A>T	ENST00000297632.6	-	5	1023	c.489T>A	c.(487-489)aaT>aaA	p.N163K		NM_194291.2	NP_919267.2	Q6PI78	TMM65_HUMAN	transmembrane protein 65	163						integral to membrane				cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	6	Lung NSC(37;1.18e-11)|Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTGACACAAGATTTCCCAAAG	0.313000													30	93					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21939016	21939016	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21939016C>T	ENST00000328843.6	+	81	13164	c.13133C>T	c.(13132-13134)cCg>cTg	p.P4378L	DNAH11_ENST00000409508.3_Missense_Mutation_p.P4371L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4378					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTTACCCTTCCGGCTGTCGTG	0.537000									Kartagener syndrome				10	226					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502502	140502502	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140502502T>C	ENST00000194152.1	+	1	922	c.922T>C	c.(922-924)Ttc>Ctc	p.F308L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		308	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAATTGGATTTCGAAAAAAT	0.363000													17	233					0	0	1	0	0
ELOVL3	83401	broad.mit.edu	37	10	103986316	103986316	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:103986316C>T	ENST00000370005.3	+	1	232	c.11C>T	c.(10-12)gCc>gTc	p.A4V		NM_152310.1	NP_689523.1	Q9HB03	ELOV3_HUMAN	ELOVL fatty acid elongase 3	4					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(2)|lung(10)|ovary(2)|prostate(1)|skin(1)	16		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		ATGGTCACAGCCATGAATGTC	0.527000													11	93					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	68					0	0	1	0	0
MGME1	92667	broad.mit.edu	37	20	17968909	17968909	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:17968909G>A	ENST00000377710.5	+	4	1120	c.832G>A	c.(832-834)Gcc>Acc	p.A278T	MGME1_ENST00000377704.4_Intron|MGME1_ENST00000467391.1_3'UTR|MGME1_ENST00000377709.1_Missense_Mutation_p.A198T	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		ATACATGGGTGCCATGAACCA	0.443000													28	44					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64536983	64536983	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64536983C>T	ENST00000377390.3	-	6	915	c.578G>A	c.(577-579)gGc>gAc	p.G193D	SF1_ENST00000422298.2_Missense_Mutation_p.G78D|SF1_ENST00000227503.9_Missense_Mutation_p.G193D|SF1_ENST00000377387.1_Missense_Mutation_p.G318D|SF1_ENST00000377394.3_Missense_Mutation_p.G193D|SF1_ENST00000489544.1_5'UTR|SF1_ENST00000433274.2_Missense_Mutation_p.G167D|SF1_ENST00000334944.5_Missense_Mutation_p.G193D	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	193	KH.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						CAACATCTGGCCATCTTTGCG	0.517000													24	329					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	780544	780544	+	Missense_Mutation	SNP	G	G	A	rs143166023		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:780544G>A	ENST00000540986.1	-	10	2433	c.998C>T	c.(997-999)gCg>gTg	p.A333V	NARFL_ENST00000562862.1_5'UTR|NARFL_ENST00000568545.1_Missense_Mutation_p.A333V|NARFL_ENST00000251588.2_Missense_Mutation_p.A435V			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	435					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				AACCCCAGGCGCGTCCTCGGG	0.682000													32	117					0	0	1	0	0
SMARCC1	6599	broad.mit.edu	37	3	47704027	47704027	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:47704027C>T	ENST00000254480.5	-	20	2074	c.1955G>A	c.(1954-1956)cGt>cAt	p.R652H	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	652	SANT.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		ATCCTGAGTACGACTTCCAAC	0.458000													21	49					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	91972488	91972488	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:91972488C>T	ENST00000265742.3	+	6	1314	c.938C>T	c.(937-939)tCt>tTt	p.S313F		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	313							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACTACACGCTCTTCTGTCACC	0.473000													5	67					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9224815	9224815	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:9224815G>A	ENST00000382496.5	-	8	1282	c.617C>T	c.(616-618)aCg>aTg	p.T206M		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	206	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GTACTGCGCCGTGCGGAGAGG	0.512000													17	38					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32371563	32371563	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:32371563G>C	ENST00000375200.1	+	12	2110	c.1745G>C	c.(1744-1746)cGg>cCg	p.R582P	ZNF341_ENST00000342427.2_Missense_Mutation_p.R575P			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						CGCTACCTGCGGCGTCATCTG	0.587000													25	95					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150648901	150648901	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150648901G>A	ENST00000392968.2	-	5	2412	c.1292C>T	c.(1291-1293)gCg>gTg	p.A431V	KCNH2_ENST00000262186.5_Missense_Mutation_p.A527V|KCNH2_ENST00000430723.3_Missense_Mutation_p.A527V|KCNH2_ENST00000330883.4_Missense_Mutation_p.A187V			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	527					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CAGCAGCCGCGCAGTCTTCAG	0.667000													17	45					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2979480	2979480	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:2979480T>G	ENST00000396946.4	-	6	1170	c.767A>C	c.(766-768)gAc>gCc	p.D256A		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	256					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ATTTTCAATGTCATTCTTCAG	0.468000			Mis		DLBCL								42	146					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125467155	125467155	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:125467155T>C	ENST00000308736.2	-	3	389	c.291A>G	c.(289-291)ctA>ctG	p.L97L		NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	97							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TCAGCTTCTGTAGCATCTCTG	0.458000													6	391					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17281861	17281861	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17281861C>T	ENST00000375541.5	+	24	3589	c.3520C>T	c.(3520-3522)Cgg>Tgg	p.R1174W		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1174					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TGACGGGCTGCGGCGGGAGCT	0.721000													12	51					0	0	1	0	0
GPR173	54328	broad.mit.edu	37	X	53105860	53105860	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:53105860C>T	ENST00000332582.4	+	2	548	c.57C>T	c.(55-57)tcC>tcT	p.S19S		NM_018969.5	NP_061842.1	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	19						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)	16						CCCCACCGTCCGCATCAGCTT	0.617000													14	17					0	0	1	0	0
GPR37L1	9283	broad.mit.edu	37	1	202096921	202096921	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:202096921G>A	ENST00000367282.4	+	2	789	c.683G>A	c.(682-684)cGc>cAc	p.R228H		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1	228						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						GGCATTGACCGCTTCCACGTG	0.592000													24	54					0	0	1	0	0
RNASE9	390443	broad.mit.edu	37	14	21024858	21024858	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21024858T>G	ENST00000557068.1	-	4	2096	c.371A>C	c.(370-372)aAg>aCg	p.K124T	RNASE9_ENST00000338904.3_Missense_Mutation_p.K124T|RNASE9_ENST00000553706.1_Missense_Mutation_p.K129T|RNASE9_ENST00000557209.1_Missense_Mutation_p.K129T|RNASE9_ENST00000556208.1_Missense_Mutation_p.K129T|RNASE9_ENST00000429244.2_Missense_Mutation_p.K124T|RNASE9_ENST00000404716.3_Missense_Mutation_p.K129T|RNASE9_ENST00000555230.1_Missense_Mutation_p.K124T|RNASE9_ENST00000553541.1_Missense_Mutation_p.K124T|RNASE9_ENST00000554964.1_Missense_Mutation_p.K124T			P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	124						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|ovary(2)|urinary_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		AATTCCATTCTTACATGGCAC	0.363000													17	29					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33390830	33390830	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:33390830G>A	ENST00000242067.6	+	14	1953		c.e14-1		BBS9_ENST00000350941.3_Intron|BBS9_ENST00000354265.4_Intron|BBS9_ENST00000355070.2_Splice_Site|BBS9_ENST00000396127.2_Intron	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9						fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			ATTGCTTATAGCACCAGATTT	0.328000									Bardet-Biedl syndrome				17	39					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54101589	54101589	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:54101589T>C	ENST00000404125.1	-	43	5042	c.4987A>G	c.(4987-4989)Acc>Gcc	p.T1663A	PSME4_ENST00000421748.2_Missense_Mutation_p.T807A|PSME4_ENST00000476586.1_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	1663					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TGGAGGTAGGTCAGTACTGTG	0.378000													14	51					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73564668	73564668	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:73564668A>G	ENST00000392550.3	+	11	1265	c.1148A>G	c.(1147-1149)cAc>cGc	p.H383R	LLGL2_ENST00000577200.1_Missense_Mutation_p.H383R|LLGL2_ENST00000167462.5_Missense_Mutation_p.H383R	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	383					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GCTTCTCTGCACTGTTCCGCC	0.637000													4	60					0	0	1	0	0
PATE1	160065	broad.mit.edu	37	11	125617283	125617283	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:125617283T>C	ENST00000305738.5	+	3	113	c.101T>C	c.(100-102)gTt>gCt	p.V34A	PATE1_ENST00000437148.2_Intron	NM_138294.2	NP_612151.1	Q8WXA2	PATE1_HUMAN	prostate and testis expressed 1	34						extracellular region				large_intestine(1)|lung(5)	6						AATGAAATAGTTGCTGTGAAA	0.393000													52	195					0	0	1	0	0
IPCEF1	26034	broad.mit.edu	37	6	154521162	154521162	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:154521162C>T	ENST00000265198.4	-	10	702	c.547G>A	c.(547-549)Gca>Aca	p.A183T	IPCEF1_ENST00000367220.4_Missense_Mutation_p.A184T|IPCEF1_ENST00000422970.2_Missense_Mutation_p.A184T|OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000519091.1_5'UTR|IPCEF1_ENST00000519344.1_Missense_Mutation_p.A155T	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						GATGAAGATGCCTGCTGTGCA	0.388000													10	43					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255808	140255808	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140255808T>C	ENST00000398631.2	+	1	751	c.751T>C	c.(751-753)Ttg>Ctg	p.L251L	PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAAGTAGTGTTGTCTGAAAA	0.423000													7	143					0	0	1	0	0
RAC3	5881	broad.mit.edu	37	17	79991386	79991386	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:79991386G>T	ENST00000306897.4	+	5	497	c.359G>T	c.(358-360)cGc>cTc	p.R120L		NM_005052.2	NP_005043.1	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	120					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding			NS(1)|kidney(1)|skin(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CTGGACCTCCGCGACGACAAG	0.667000													15	43					7.05477e-17	7.41646e-17	1	1	0
EIF2AK3	9451	broad.mit.edu	37	2	88870488	88870488	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:88870488G>A	ENST00000303236.3	-	14	3190	c.2889C>T	c.(2887-2889)gaC>gaT	p.D963D	EIF2AK3_ENST00000419748.1_Silent_p.D812D|EIF2AK3_ENST00000470706.1_5'UTR|AC104134.2_ENST00000413234.1_RNA	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	963	Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						CCTCATCCTGGTCCATTGCAG	0.468000													39	124					0	0	1	0	0
TOMM20L	387990	broad.mit.edu	37	14	58869469	58869469	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:58869469G>A	ENST00000360945.2	+	3	294	c.252G>A	c.(250-252)tgG>tgA	p.W84*	RP11-517O13.1_ENST00000556734.1_RNA	NM_207377.2	NP_997260.1	Q6UXN7	TO20L_HUMAN	translocase of outer mitochondrial membrane 20 homolog (yeast)-like	84					protein targeting	integral to membrane|mitochondrial outer membrane translocase complex				large_intestine(2)|lung(2)	4						GAGAACTTTGGTTATCTAGAG	0.308000													8	152					0	0	1	0	0
FBXL3	26224	broad.mit.edu	37	13	77581451	77581451	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:77581451T>C	ENST00000355619.5	-	5	1440	c.1116A>G	c.(1114-1116)tcA>tcG	p.S372S	FBXL3_ENST00000477982.1_Intron	NM_012158.2	NP_036290.1	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	372					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|urinary_tract(1)	16		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		AGGCACTACATGAGACTTCAC	0.408000													26	102					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33565879	33565879	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:33565879T>C	ENST00000262873.7	+	3	289	c.197T>C	c.(196-198)gTg>gCg	p.V66A		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	24						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			ATGACGAAGGTGCACACTATC	0.592000													31	90					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250599	140250599	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140250599C>T	ENST00000398640.2	+	1	1911	c.1911C>T	c.(1909-1911)gaC>gaT	p.D637D	PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron	NM_018902.3	NP_061725.1												p.D637D(1)		breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCCTGGACGAGGCAGACT	0.662000													34	115					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40629496	40629496	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:40629496T>C	ENST00000298910.7	+	4	474	c.416T>C	c.(415-417)tTa>tCa	p.L139S	LRRK2_ENST00000343742.2_Missense_Mutation_p.L139S	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	139					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTGAAGACCTTAGATCTCCTC	0.308000													10	55					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133579	91133579	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:91133579A>G	ENST00000373094.1	+	2	3185	c.2340A>G	c.(2338-2340)acA>acG	p.T780T	PCDH11X_ENST00000298274.8_Silent_p.T780T|PCDH11X_ENST00000504220.1_Silent_p.T780T|PCDH11X_ENST00000406881.1_Silent_p.T780T|PCDH11X_ENST00000373097.1_Silent_p.T780T|PCDH11X_ENST00000395337.2_Silent_p.T780T|PCDH11X_ENST00000373088.1_Silent_p.T780T|PCDH11X_ENST00000361724.1_Silent_p.T780T|PCDH11X_ENST00000361655.2_Silent_p.T780T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	780	Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCAATGCTACACTGATTAATG	0.438000													50	48					0	0	1	0	0
MVB12A	93343	broad.mit.edu	37	19	17534318	17534318	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17534318G>A	ENST00000317040.7	+	5	1480	c.425G>A	c.(424-426)gGc>gAc	p.G142D	MVB12A_ENST00000528515.1_Missense_Mutation_p.A100T|MVB12A_ENST00000529939.1_Missense_Mutation_p.G142D|MVB12A_ENST00000543795.1_Missense_Mutation_p.G142D|MVB12A_ENST00000392702.2_Intron					multivesicular body subunit 12A																		GACATGGGCGGCTTTGCCATC	0.687000													25	98					0	0	1	0	0
GGTLC1	92086	broad.mit.edu	37	20	23966824	23966824	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:23966824G>A	ENST00000335694.4	-	3	397	c.193C>T	c.(193-195)Cgc>Tgc	p.R65C	GGTLC1_ENST00000286890.4_Missense_Mutation_p.R65C|GGTLC1_ENST00000278765.4_Missense_Mutation_p.R65C	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	65							gamma-glutamyltransferase activity	p.R65C(2)		NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						ACTGGGGAGCGCACCTTGGAG	0.572000													31	88					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155206586	155206586	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:155206586G>A	ENST00000460012.1	-	20	2669	c.2312C>T	c.(2311-2313)cCt>cTt	p.P771L	PLCH1_ENST00000494598.1_Missense_Mutation_p.P789L|PLCH1_ENST00000447496.2_Missense_Mutation_p.P789L|PLCH1_ENST00000414191.1_Missense_Mutation_p.P771L|PLCH1_ENST00000334686.6_Missense_Mutation_p.P771L|PLCH1_ENST00000340059.7_Missense_Mutation_p.P789L			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	789	C2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTCCCACACAGGGTTAAATCC	0.423000													7	54					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11832719	11832719	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11832719G>A	ENST00000341191.6	-	4	1783	c.1630C>T	c.(1630-1632)Cga>Tga	p.R544*	ZNF823_ENST00000545749.1_Nonsense_Mutation_p.R362*	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						CTTTCATGTCGTAGAAGGCAA	0.408000										HNSCC(68;0.2)			16	72					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42439479	42439479	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:42439479C>T	ENST00000397272.3	-	13	1359	c.1268G>A	c.(1267-1269)cGt>cAt	p.R423H	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.R421H	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	421	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		AACCTGGGCACGCTCAATGGG	0.632000													10	52					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104159907	104159907	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:104159907G>A	ENST00000369966.3	+	15	1790	c.1540G>A	c.(1540-1542)Gcc>Acc	p.A514T	NFKB2_ENST00000189444.6_Missense_Mutation_p.A514T|NFKB2_ENST00000428099.1_Missense_Mutation_p.A514T	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	514					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CATCCACCACGCCCAGGACCT	0.632000			T	IGH@	B-NHL								34	75					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61026740	61026740	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:61026740C>T	ENST00000335613.5	-	20	2661	c.2275G>A	c.(2275-2277)Gga>Aga	p.G759R	VWCE_ENST00000535710.1_Missense_Mutation_p.G224R	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	759						extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GCCACATTTCCGTGAGGGGAG	0.582000													22	61					0	0	1	0	0
U2AF2	11338	broad.mit.edu	37	19	56185344	56185344	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56185344G>A	ENST00000450554.2	+	12	2285	c.1326G>A	c.(1324-1326)atG>atA	p.M442I	CTD-2537I9.12_ENST00000585940.1_RNA|U2AF2_ENST00000590551.1_Missense_Mutation_p.M278I|CTD-2537I9.12_ENST00000589456.1_RNA|U2AF2_ENST00000308924.4_Missense_Mutation_p.M446I	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	446	RRM 3.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		AGAAAGCCATGCAGGGCCTGA	0.562000													28	117					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70852717	70852717	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:70852717A>G	ENST00000358731.4	+	36	7468	c.7205A>G	c.(7204-7206)cAc>cGc	p.H2402R	BDP1_ENST00000380675.2_3'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2402					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		aaataGGTGCACTCAAAGGAA	0.234000													6	26					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334470	56334470	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56334470C>T	ENST00000331886.5	+	12	1435	c.981C>T	c.(979-981)caC>caT	p.H327H	DGKA_ENST00000394147.1_Silent_p.H327H|DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000551156.1_Silent_p.H327H	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	327					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TCCGGGATCACATCCTGCCTC	0.602000											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	119					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50681875	50681875	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:50681875C>T	ENST00000446044.1	+	8	1136	c.540C>T	c.(538-540)gaC>gaT	p.D180D	MAPKAPK3_ENST00000357955.2_Silent_p.D180D	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	180	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		AGGAGAAAGACGCAGTGCTTA	0.502000													29	95					0	0	1	0	0
MARCH5	54708	broad.mit.edu	37	10	94109493	94109493	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:94109493A>G	ENST00000358935.2	+	5	951	c.619A>G	c.(619-621)Act>Gct	p.T207A	MARCH5_ENST00000467521.2_3'UTR	NM_017824.4	NP_060294.1	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	207					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						TGTCTCTGCTACTCGAATCTT	0.403000													10	292					0	0	1	0	0
TREX1	11277	broad.mit.edu	37	3	48508760	48508760	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:48508760A>G	ENST00000296443.9	+	3	1593	c.706A>G	c.(706-708)Aca>Gca	p.T236A	TREX1_ENST00000456089.1_Missense_Mutation_p.T97A|TREX1_ENST00000422277.2_Missense_Mutation_p.T291A|TREX1_ENST00000444177.1_Missense_Mutation_p.T226A|TREX1_ENST00000436480.2_Missense_Mutation_p.T236A|TREX1_ENST00000433541.1_Missense_Mutation_p.T97A|TREX1_ENST00000492235.1_3'UTR			Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1	291					cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|skin(3)	9				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GTATGGGGTCACAGCCTCTGC	0.617000													29	95					0	0	1	0	0
ARSA	410	broad.mit.edu	37	22	51064693	51064693	+	Missense_Mutation	SNP	G	G	A	rs74315473		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:51064693G>A	ENST00000547307.1	-	5	1267	c.862C>T	c.(862-864)Cgt>Tgt	p.R288C	ARSA_ENST00000547805.1_Missense_Mutation_p.R288C|ARSA_ENST00000395619.3_Missense_Mutation_p.R290C|ARSA_ENST00000395621.3_Missense_Mutation_p.R290C|ARSA_ENST00000216124.5_Missense_Mutation_p.R290C|ARSA_ENST00000356098.5_Missense_Mutation_p.R290C|ARSA_ENST00000453344.2_Missense_Mutation_p.R204C			P15289	ARSA_HUMAN	arylsulfatase A	288			R -> C (in MLD).|R -> H (in MLD; adult form).			lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|skin(1)	9		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	CGGGACATACGCATGGTCTCA	0.637000													13	23					0	0	1	0	0
HSDL1	83693	broad.mit.edu	37	16	84163829	84163829	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84163829T>C	ENST00000219439.4	-	4	604	c.428A>G	c.(427-429)aAa>aGa	p.K143R	HSDL1_ENST00000434463.3_Intron	NM_001146051.1|NM_031463.4	NP_001139523.1|NP_113651.4	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1	143						mitochondrion	oxidoreductase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7						GCCAACGTCTTTGTCCTTCAG	0.473000													5	198					0	0	1	0	0
CCDC151	115948	broad.mit.edu	37	19	11532352	11532352	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11532352T>C	ENST00000356392.4	-	11	1670	c.1583A>G	c.(1582-1584)aAc>aGc	p.N528S	CCDC151_ENST00000586836.1_Missense_Mutation_p.N337S|CCDC151_ENST00000545100.1_Missense_Mutation_p.N474S|CCDC151_ENST00000591179.1_Missense_Mutation_p.N468S	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	528										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						CACCTCGCGGTTAGCGATGTG	0.617000													52	165					0	0	1	0	0
KHK	3795	broad.mit.edu	37	2	27322364	27322364	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27322364G>A	ENST00000260599.6	+	7	1243	c.730G>A	c.(730-732)Gct>Act	p.A244T	CGREF1_ENST00000402550.1_3'UTR|CGREF1_ENST00000452318.2_3'UTR|KHK_ENST00000260598.5_Missense_Mutation_p.A244T|KHK_ENST00000490823.1_3'UTR	NM_000221.2	NP_000212.1	P50053	KHK_HUMAN	ketohexokinase (fructokinase)	244					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCACTCGGATGCTTTCCCGCC	0.632000													34	93					0	0	1	0	0
LOXL4	84171	broad.mit.edu	37	10	100013338	100013338	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:100013338C>A	ENST00000260702.3	-	11	1957	c.1807G>T	c.(1807-1809)Gat>Tat	p.D603Y	RP11-34A14.3_ENST00000433374.1_RNA	NM_032211.6	NP_115587.6	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4	603	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(8)|ovary(4)|prostate(1)|skin(2)	26		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		ACCCAGCTATCGCGTCCAGTC	0.567000													11	82					9.05144e-12	9.41241e-12	1	1	0
RYR2	6262	broad.mit.edu	37	1	237659870	237659870	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:237659870A>G	ENST00000366574.2	+	20	2338	c.2021A>G	c.(2020-2022)tAc>tGc	p.Y674C	RYR2_ENST00000360064.6_Missense_Mutation_p.Y672C|RYR2_ENST00000542537.1_Missense_Mutation_p.Y658C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	674	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGAAATGGTACTATGAATTG	0.463000													28	61					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15437503	15437503	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:15437503C>T	ENST00000295297.4	+	2	416	c.157C>T	c.(157-159)Cct>Tct	p.P53S	C1QTNF7_ENST00000429690.1_Missense_Mutation_p.P46S|C1QTNF7_ENST00000444304.2_Missense_Mutation_p.P46S	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	46	Collagen-like.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						TCCAGGGCCCCCTGGAGCAAA	0.572000													20	55					0	0	1	0	0
GPR182	11318	broad.mit.edu	37	12	57389733	57389733	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:57389733A>G	ENST00000300098.1	+	2	959	c.740A>G	c.(739-741)cAg>cGg	p.Q247R		NM_007264.3	NP_009195.1	O15218	GP182_HUMAN	G protein-coupled receptor 182	247						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	15						CGGCTGCGGCAGCCAGGACAA	0.647000													25	79					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89202827	89202827	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:89202827C>T	ENST00000554922.1	-	7	1178	c.930G>A	c.(928-930)gtG>gtA	p.V310V	EML5_ENST00000380664.5_Silent_p.V310V|EML5_ENST00000352093.5_Silent_p.V310V	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	310						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TTCTTTCTTGCACCACAATTT	0.403000													50	154					0	0	1	0	0
NFIB	4781	broad.mit.edu	37	9	14150259	14150259	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:14150259T>C	ENST00000380959.3	-	5	1164	c.691A>G	c.(691-693)Ata>Gta	p.I231V	NFIB_ENST00000397581.2_Missense_Mutation_p.I231V|NFIB_ENST00000543693.1_5'UTR|NFIB_ENST00000380934.4_Missense_Mutation_p.I257V|NFIB_ENST00000397579.2_Missense_Mutation_p.I231V|NFIB_ENST00000380924.1_5'UTR|NFIB_ENST00000380953.1_Missense_Mutation_p.I231V|NFIB_ENST00000397575.3_Missense_Mutation_p.I231V	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	231					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		CCCTGGGTTATGGGCGCTGAG	0.443000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								90	287					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68014034	68014034	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:68014034C>T	ENST00000268793.4	-	1	698	c.325G>A	c.(325-327)Gcg>Acg	p.A109T	DPEP3_ENST00000574342.1_5'UTR	NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	84					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		AGGGCCTGCGCGCGACCCCGA	0.672000													18	67					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1004694	1004694	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1004694G>A	ENST00000234389.3	+	3	1213	c.1194G>A	c.(1192-1194)ccG>ccA	p.P398P	GRIN3B_ENST00000588335.1_Intron	NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	398					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	ACTTGGAACCGGGAGGTGCCT	0.697000													4	26					0	0	1	0	0
DNAJC1	64215	broad.mit.edu	37	10	22209773	22209773	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:22209773A>G	ENST00000376980.3	-	4	781	c.491T>C	c.(490-492)gTg>gCg	p.V164A	DNAJC1_ENST00000376946.1_3'UTR	NM_022365.3	NP_071760.2	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	164					negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(13)|skin(2)|upper_aerodigestive_tract(2)	21		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				ATAATGACCCACTGTGAGAAT	0.393000													28	84					0	0	1	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22864404	22864404	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:22864404T>C	ENST00000251822.6	+	5	1183	c.646T>C	c.(646-648)Ttc>Ctc	p.F216L	RP11-875O11.1_ENST00000502083.2_RNA|RHOBTB2_ENST00000519685.1_Missense_Mutation_p.F238L|RP11-875O11.1_ENST00000523884.1_RNA|RHOBTB2_ENST00000522948.1_Missense_Mutation_p.F223L	NM_015178.2	NP_055993.2	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2	216					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	31		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CCACCTGCAGTTCTGGAAGTC	0.642000													19	194					0	0	1	0	0
AMT	275	broad.mit.edu	37	3	49455120	49455120	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49455120A>G	ENST00000273588.3	-	9	1367	c.1065T>C	c.(1063-1065)tcT>tcC	p.S355S	AMT_ENST00000538581.1_Silent_p.S299S|AMT_ENST00000476226.1_5'UTR|AMT_ENST00000546031.1_Silent_p.S258S|AMT_ENST00000458307.2_Silent_p.S311S|AMT_ENST00000395338.2_Silent_p.S355S	NM_000481.3	NP_000472.2	P48728	GCST_HUMAN	aminomethyltransferase	355					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCTTCTTCAGAGAGGGGGAGG	0.592000													42	143					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739798	38739798	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:38739798A>G	ENST00000449082.2	-	27	4912	c.4913T>C	c.(4912-4914)aTc>aCc	p.I1638T		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1638					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CATGTCGTCGATGCCAGCCTC	0.557000													52	169					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123847263	123847263	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:123847263G>A	ENST00000369005.1	+	4	5588	c.5248G>A	c.(5248-5250)Gcc>Acc	p.A1750T	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.A1750T|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.A1750T|TACC2_ENST00000453444.2_Missense_Mutation_p.A1750T|TACC2_ENST00000515273.1_Missense_Mutation_p.A1750T	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1750						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TCAGGACCCAGCCTGCTCTGA	0.632000													12	20					0	0	1	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659497	63659497	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:63659497G>A	ENST00000523211.1	+	4	412	c.280G>A	c.(280-282)Gat>Aat	p.D94N	NKAIN3_ENST00000328472.5_Missense_Mutation_p.D94N|NKAIN3_ENST00000519049.1_3'UTR	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	94						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				CTAGGACACCGATCTAATGAC	0.448000													17	44					0	0	1	0	0
PGM2	55276	broad.mit.edu	37	4	37851807	37851807	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:37851807A>G	ENST00000381967.4	+	12	1515	c.1415A>G	c.(1414-1416)tAt>tGt	p.Y472C	PGM2_ENST00000537241.1_Missense_Mutation_p.Y312C	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	472					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						TTTGATAGGTATGGCTACCAT	0.313000													5	24					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229613	140229613	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140229613C>T	ENST00000378122.3	+	1	2257	c.1533C>T	c.(1531-1533)caC>caT	p.H511H	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Silent_p.H511H|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCAGTGCACGCGGAGAGCG	0.701000													64	205					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243457	46243457	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:46243457A>G	ENST00000334344.6	+	14	1982	c.1810A>G	c.(1810-1812)Ata>Gta	p.I604V	ARID2_ENST00000422737.1_Missense_Mutation_p.I455V|ARID2_ENST00000444670.1_Missense_Mutation_p.I214V|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	604					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACGGAGGGCTATACCACTTCC	0.453000			"""N, S, F"""		hepatocellular carcinoma								5	304					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35480372	35480372	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35480372A>G	ENST00000357182.4	-	6	948	c.721T>C	c.(721-723)Tat>Cat	p.Y241H	ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000487874.1_Missense_Mutation_p.Y241H|ZMYM6_ENST00000373340.2_Missense_Mutation_p.Y241H	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	241					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CTATAGCAATAGCTCCCACAG	0.393000													18	61					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80037120	80037120	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:80037120C>T	ENST00000306749.2	-	43	7653	c.7435G>A	c.(7435-7437)Ggt>Agt	p.G2479S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	2479	Thioesterase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGGTGGTCACCCTCGATGACG	0.657000													8	107					0	0	1	0	0
RFX1	5989	broad.mit.edu	37	19	14077341	14077341	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14077341G>A	ENST00000254325.4	-	14	2087	c.1851_splice	c.e14-1	p.A618_splice		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	618					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GTCGACAATGGCCTGTGGCAG	0.667000													20	45					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770140	112770140	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:112770140C>T	ENST00000390666.3	-	1	588	c.397G>A	c.(397-399)Gtc>Atc	p.V133I	CTD-2201G3.1_ENST00000416046.2_RNA|MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	133	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.V133I(2)		large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCCCGGTGGACGACGTCCAGG	0.557000													18	77					0	0	1	0	0
ERGIC1	57222	broad.mit.edu	37	5	172359522	172359522	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:172359522T>C	ENST00000393784.3	+	8	764	c.625T>C	c.(625-627)Tac>Cac	p.Y209H		NM_001031711.2	NP_001026881.1	Q969X5	ERGI1_HUMAN	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	209					ER to Golgi vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)	9	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTCCTACCAGTACACGGTGGC	0.642000											OREG0017050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	42					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22396403	22396403	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:22396403A>G	ENST00000263160.3	+	9	1581	c.1144A>G	c.(1144-1146)Acg>Gcg	p.T382A		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	382					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						TCTTTCAACTACGACAGTGAG	0.373000													47	143					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21123524	21123524	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:21123524G>A	ENST00000269228.5	-	14	2694	c.2140C>T	c.(2140-2142)Cgt>Tgt	p.R714C	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.R396C	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	714	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCTTGAAGACGTTCATCTCTC	0.398000													25	62					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140812493	140812493	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140812493C>T	ENST00000252085.3	+	1	2309	c.2167C>T	c.(2167-2169)Cgc>Tgc	p.R723C	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACAAGTCACGCCTGCTGCA	0.657000													61	172					0	0	1	0	0
ANKRD1	27063	broad.mit.edu	37	10	92675593	92675593	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:92675593A>G	ENST00000371697.3	-	7	944	c.696T>C	c.(694-696)taT>taC	p.Y232Y		NM_014391.2	NP_055206.2	Q15327	ANKR1_HUMAN	ankyrin repeat domain 1 (cardiac muscle)	232					cellular lipid metabolic process|defense response|signal transduction		DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|prostate(3)|skin(1)	27		Colorectal(252;0.0475)				CCGCGCACTCATAGTGGCCAG	0.542000													9	42					0	0	1	0	0
MAU2	23383	broad.mit.edu	37	19	19455728	19455728	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19455728C>T	ENST00000392313.5	+	11	1194	c.1148C>T	c.(1147-1149)aCa>aTa	p.T383I	MAU2_ENST00000262815.8_Missense_Mutation_p.T383I	NM_015329.3	NP_056144.3	Q9Y6X3	SCC4_HUMAN	MAU2 sister chromatid cohesion factor	383					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						CAGCTGCACACATTGCTGGTG	0.552000													17	43					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184105783	184105783	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:184105783T>C	ENST00000204604.1	+	20	2762	c.2516T>C	c.(2515-2517)gTg>gCg	p.V839A	CHRD_ENST00000348986.3_Missense_Mutation_p.V799A|CHRD_ENST00000450923.1_Missense_Mutation_p.V839A|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Missense_Mutation_p.V381A	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	839	VWFC 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCCAGCCTGTGCGTGTCAAC	0.617000													11	35					0	0	1	0	0
DHX58	79132	broad.mit.edu	37	17	40260095	40260095	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:40260095A>G	ENST00000251642.3	-	7	932	c.710T>C	c.(709-711)aTg>aCg	p.M237T		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	237					innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GATTTGGTCCATGAGCTTCTT	0.552000													8	108					0	0	1	0	0
SKP1	6500	broad.mit.edu	37	5	133494134	133494134	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:133494134T>C	ENST00000522552.1	-	5	577	c.468A>G	c.(466-468)acA>acG	p.T156T	SKP1_ENST00000517625.1_Intron|SKP1_ENST00000353411.6_Intron|SKP1_ENST00000522855.1_Intron|SKP1_ENST00000521216.1_Intron	NM_006930.3	NP_008861.2	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1	157	Interaction with the F-box domain of F- box proteins (By similarity).				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACAAAACTGTGTGCTACCTA	0.408000													18	171					0	0	1	0	0
TMA16	55319	broad.mit.edu	37	4	164436611	164436611	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:164436611T>C	ENST00000358572.5	+	5	727	c.386T>C	c.(385-387)cTt>cCt	p.L129P	TMA16_ENST00000513134.1_Intron|TMA16_ENST00000511562.1_3'UTR|TMA16_ENST00000513272.1_Intron|TMA16_ENST00000508268.1_Missense_Mutation_p.L129P	NM_018352.2	NP_060822.2	Q96EY4	CD043_HUMAN	translation machinery associated 16 homolog (S. cerevisiae)	129																	GGATATGGCCTTGGTGTGCTC	0.433000													10	142					0	0	1	0	0
SERAC1	84947	broad.mit.edu	37	6	158579328	158579328	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:158579328C>T	ENST00000367102.2	-	2	209	c.68G>A	c.(67-69)aGt>aAt	p.S23N	SERAC1_ENST00000607000.1_Missense_Mutation_p.S23N|SERAC1_ENST00000367104.3_Missense_Mutation_p.S23N|SERAC1_ENST00000367101.1_Missense_Mutation_p.S23N			Q96JX3	SRAC1_HUMAN	serine active site containing 1	23					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		GTGTGTGCCACTTTTTGGTGG	0.398000													5	92					0	0	1	0	0
GUSB	2990	broad.mit.edu	37	7	65444432	65444432	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:65444432G>T	ENST00000304895.4	-	4	808	c.678C>A	c.(676-678)acC>acA	p.T226T	GUSB_ENST00000476486.1_5'UTR|GUSB_ENST00000421103.1_Intron|GUSB_ENST00000345660.6_Silent_p.T226T	NM_000181.3	NP_000172.2	P08236	BGLR_HUMAN	glucuronidase, beta	226					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding			breast(1)|cervix(2)|kidney(2)|large_intestine(4)|lung(10)|skin(1)	20						CATCGATGTAGGTGGTGGGTG	0.527000													11	117					6.40141e-05	6.51258e-05	1	1	0
MMRN1	22915	broad.mit.edu	37	4	90857093	90857093	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:90857093T>C	ENST00000394980.1	+	7	2581	c.2262T>C	c.(2260-2262)acT>acC	p.T754T	MMRN1_ENST00000508372.1_Silent_p.T496T|MMRN1_ENST00000264790.2_Silent_p.T754T|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	754					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CTTTAAGTACTATTAAGGATA	0.323000													13	46					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31319297	31319297	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:31319297G>A	ENST00000542188.1	-	25	3681	c.3368C>T	c.(3367-3369)tCa>tTa	p.S1123L	TRPM1_ENST00000397795.2_Missense_Mutation_p.S1084L|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000256552.6_Missense_Mutation_p.S1106L|RP11-348B17.1_ENST00000558755.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1084					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GTTGGATATTGATTTTACTTC	0.378000													14	61					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74703101	74703101	+	Missense_Mutation	SNP	C	C	T	rs140128092		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:74703101C>T	ENST00000261918.4	-	14	2413	c.1865G>A	c.(1864-1866)cGc>cAc	p.R622H	SEMA7A_ENST00000543145.2_Missense_Mutation_p.R608H|SEMA7A_ENST00000542748.1_Missense_Mutation_p.R457H	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	622	Ig-like C2-type.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						CTGAGCCTCGCGGAAGTAGGA	0.667000													9	54					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537721	55537721	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:55537721A>T	ENST00000220676.1	+	4	1427	c.1279A>T	c.(1279-1281)Aat>Tat	p.N427Y		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	427					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAGTTGGGAGAATGCTACTGT	0.448000													32	134					0	0	1	0	0
HSPA5	3309	broad.mit.edu	37	9	127999357	127999357	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:127999357C>T	ENST00000324460.6	-	8	1682	c.1479G>A	c.(1477-1479)ggG>ggA	p.G493G		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	493					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	TCTGTGGGACCCCACGAGGAG	0.423000										Prostate(1;0.17)			22	67					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76803760	76803760	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:76803760G>A	ENST00000338487.5	-	2	215	c.216C>T	c.(214-216)gaC>gaT	p.D72D		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	72	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GCCTATAGCGGTCCAGCGCCG	0.701000													23	60					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104678805	104678805	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:104678805T>C	ENST00000369878.3	+	1	692	c.568T>C	c.(568-570)Tac>Cac	p.Y190H	CNNM2_ENST00000433628.2_Missense_Mutation_p.Y190H|CNNM2_ENST00000369875.3_Missense_Mutation_p.Y190H	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	190					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAAGTCCTATTACCTGTGCAC	0.657000													75	232					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10755966	10755966	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:10755966C>T	ENST00000416569.2	-	3	1448	c.1422G>A	c.(1420-1422)gtG>gtA	p.V474V	XKR6_ENST00000304437.2_Silent_p.V195V	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	474						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		ACAGTGCTGGCACCGCATAGG	0.478000													13	32					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19422136	19422136	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:19422136T>A	ENST00000375267.2	-	93	13532	c.13529A>T	c.(13528-13530)aAa>aTa	p.K4510I	UBR4_ENST00000375254.3_Missense_Mutation_p.K4510I|UBR4_ENST00000543981.1_Missense_Mutation_p.K174I|UBR4_ENST00000467272.2_5'UTR|UBR4_ENST00000375217.2_Missense_Mutation_p.K4503I|UBR4_ENST00000375224.1_Missense_Mutation_p.K217I|UBR4_ENST00000375226.2_Missense_Mutation_p.K4486I|UBR4_ENST00000429347.2_Missense_Mutation_p.K73I			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	4510					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ACTGAACAATTTCAGTAGCAC	0.493000													17	38					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19477442	19477442	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:19477442C>T	ENST00000396229.2	+	9	2273	c.1524C>T	c.(1522-1524)taC>taT	p.Y508Y	TMC5_ENST00000542583.2_Silent_p.Y508Y|TMC5_ENST00000564959.1_Silent_p.Y191Y|TMC5_ENST00000561503.1_Silent_p.Y149Y|TMC5_ENST00000541464.1_Silent_p.Y508Y|TMC5_ENST00000219821.5_Silent_p.Y262Y|TMC5_ENST00000381414.4_Silent_p.Y508Y	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	508						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						ATGGCTTTTACACCAATTCCA	0.458000													5	68					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41330678	41330678	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:41330678A>G	ENST00000551295.2	+	10	1198	c.1081A>G	c.(1081-1083)Aca>Gca	p.T361A	CNTN1_ENST00000360099.3_Missense_Mutation_p.T361A|CNTN1_ENST00000547702.1_Missense_Mutation_p.T361A|CNTN1_ENST00000348761.2_Missense_Mutation_p.T350A|CNTN1_ENST00000347616.1_Missense_Mutation_p.T361A|CNTN1_ENST00000547849.1_Missense_Mutation_p.T361A	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	361	Ig-like C2-type 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane		p.T361A(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GCCCATCCCTACAATCCGATG	0.478000													11	223					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51504657	51504657	+	Missense_Mutation	SNP	G	G	A	rs121434536		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:51504657G>A	ENST00000396402.1	-	9	1276	c.1123C>T	c.(1123-1125)Cgc>Tgc	p.R375C	CYP19A1_ENST00000396404.4_Missense_Mutation_p.R375C|CYP19A1_ENST00000559878.1_Missense_Mutation_p.R375C|CYP19A1_ENST00000260433.2_Missense_Mutation_p.R375C|RP11-108K3.1_ENST00000559909.1_lincRNA	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	375			R -> C (in AROD).|R -> L.		estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	AAGGCTTTGCGCATGACCAAG	0.408000													16	89					0	0	1	0	0
KCNMB2	10242	broad.mit.edu	37	3	178543536	178543536	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:178543536T>A	ENST00000432997.1	+	3	569	c.217T>A	c.(217-219)Tac>Aac	p.Y73N	KCNMB2_ENST00000420517.2_Missense_Mutation_p.Y73N|KCNMB2_ENST00000358316.3_Missense_Mutation_p.Y73N|RP11-385J1.2_ENST00000432385.1_RNA|RP11-385J1.2_ENST00000437488.1_RNA|RP11-385J1.2_ENST00000451742.1_RNA|RP11-385J1.2_ENST00000425330.1_RNA|KCNMB2_ENST00000452583.1_Missense_Mutation_p.Y73N	NM_005832.3	NP_005823.1	Q9Y691	KCMB2_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 2	73					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			NS(2)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	12	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			CCTGCGCTCATACATGCAGAG	0.532000													47	171					0	0	1	0	0
AASDH	132949	broad.mit.edu	37	4	57237793	57237793	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:57237793T>C	ENST00000205214.6	-	5	865	c.685A>G	c.(685-687)Aca>Gca	p.T229A	AASDH_ENST00000451613.1_Missense_Mutation_p.T229A|AASDH_ENST00000434343.2_5'UTR|AASDH_ENST00000510762.1_Intron|AASDH_ENST00000513376.1_Missense_Mutation_p.T129A|AASDH_ENST00000602986.1_Missense_Mutation_p.T76A|AASDH_ENST00000502617.1_Missense_Mutation_p.T229A	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	229					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TCTTCTTGTGTGATGTCAAAA	0.383000													6	66					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243328085	243328085	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:243328085T>C	ENST00000366542.1	-	13	3228	c.3177A>G	c.(3175-3177)tcA>tcG	p.S1059S	RP11-261C10.4_ENST00000437499.1_RNA|RP11-261C10.4_ENST00000422938.1_RNA|CEP170_ENST00000366544.1_Silent_p.S961S|CEP170_ENST00000366543.1_Silent_p.S961S	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	1059	Targeting to microtubules.					centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GCTCATCAGCTGAGGTAAGTG	0.418000													7	49					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129906728	129906728	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:129906728A>G	ENST00000222481.4	+	1	62	c.7A>G	c.(7-9)Atg>Gtg	p.M3V		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	3					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					ACCCATGGCCATGAGGTTGAT	0.448000													34	93					0	0	1	0	0
KIF22	3835	broad.mit.edu	37	16	29810350	29810350	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:29810350C>T	ENST00000561482.1	+	5	1037	c.400C>T	c.(400-402)Cgg>Tgg	p.R134W	KIF22_ENST00000400750.2_5'UTR|KIF22_ENST00000569382.2_Missense_Mutation_p.R134W|KIF22_ENST00000160827.4_Missense_Mutation_p.R202W|KIF22_ENST00000400751.5_Missense_Mutation_p.R134W	NM_001256270.1	NP_001243199.1	Q14807	KIF22_HUMAN	kinesin family member 22	202	Kinesin-motor.				blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding			endometrium(1)|large_intestine(1)|lung(11)|skin(1)	14						AGAAGACTGCCGGGGGAATAT	0.547000													34	164					0	0	1	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176752112	176752112	+	Splice_Site	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:176752112A>T	ENST00000430069.1	-	13	1383	c.1122_splice	c.e13-1	p.I375_splice	TBL1XR1_ENST00000457928.2_Splice_Site_p.I375_splice			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	375					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			CATACTCCATATCTAAACAAA	0.259000													7	19					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16306681	16306681	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:16306681G>A	ENST00000244769.4	-	9	3263	c.2327C>T	c.(2326-2328)gCg>gTg	p.A776V	ATXN1_ENST00000436367.1_Missense_Mutation_p.A776V	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	776	Interaction with USP7.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GCTCTCTGGCGCCGACCACCT	0.522000													31	75					0	0	1	0	0
TAF15	8148	broad.mit.edu	37	17	34171941	34171941	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:34171941T>C	ENST00000592237.1	+	18	1581	c.1052T>C	c.(1051-1053)gTg>gCg	p.V351A	TAF15_ENST00000588240.1_Silent_p.S546S|TAF15_ENST00000311979.3_Silent_p.S543S			Q92804	RBP56_HUMAN	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0	Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	lung(1)|ovary(1)|skin(2)|stomach(1)	5		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GAGACCGAAGTGGAGGCTATG	0.617000			T	"""TEC, CHN1, ZNF384"""	"""extraskeletal myxoid chondrosarcomas, ALL"""								5	148					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42264310	42264310	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:42264310A>G	ENST00000379310.3	-	33	4036	c.3968T>C	c.(3967-3969)gTt>gCt	p.V1323A	VWA8_ENST00000478987.1_5'UTR	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		ACCTTGTGTAACTCCAAACCC	0.428000													20	60					0	0	1	0	0
MIR377	494326	broad.mit.edu	37	14	101528398	101528398	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:101528398T>C	ENST00000362145.2	+	0	56					NR_029869.1																						TGAGCAGAGGTTGCCCTTGGT	0.522000													9	131					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26227699	26227699	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:26227699A>G	ENST00000380737.3	+	10	1443	c.1114A>G	c.(1114-1116)Aac>Gac	p.N372D	PPP2R2A_ENST00000315985.7_Missense_Mutation_p.N382D	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		GTTTGACAGAAACACAAAGCG	0.413000													15	64					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155490896	155490896	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155490896A>G	ENST00000302068.4	+	7	1252	c.1189A>G	c.(1189-1191)Atg>Gtg	p.M397V	FGB_ENST00000509493.1_Missense_Mutation_p.M178V|FGB_ENST00000502545.1_Intron	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	397	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AAACAGGACCATGACCATTCA	0.458000													22	61					0	0	1	0	0
SLC2A12	154091	broad.mit.edu	37	6	134350163	134350163	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:134350163T>C	ENST00000275230.5	-	2	955	c.800A>G	c.(799-801)gAt>gGt	p.D267G		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	267						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		ACGAAACAGATCCCAAAAACT	0.388000													4	89					0	0	1	0	0
HHEX	3087	broad.mit.edu	37	10	94452165	94452165	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:94452165G>A	ENST00000282728.5	+	2	2201	c.402G>A	c.(400-402)ctG>ctA	p.L134L	HHEX_ENST00000472590.2_5'UTR|HHEX_ENST00000492654.2_5'UTR	NM_002729.4	NP_002720.1	Q03014	HHEX_HUMAN	hematopoietically expressed homeobox	134					anterior/posterior pattern formation|B cell differentiation|cell cycle|DNA conformation change|negative regulation of angiogenesis|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of vascular endothelial growth factor receptor signaling pathway|poly(A)+ mRNA export from nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|Wnt receptor signaling pathway	cytoplasm|nucleus|protein-DNA complex	DNA bending activity|eukaryotic initiation factor 4E binding|protein homodimerization activity|repressing transcription factor binding|sequence-specific DNA binding|TBP-class protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(2)|lung(5)|ovary(1)	10						AGAGGCCTCTGCATAAAAGGA	0.597000													4	111					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104335655	104335655	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:104335655G>A	ENST00000361820.3	-	9	3749	c.3149C>T	c.(3148-3150)cCa>cTa	p.P1050L		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	1050					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCTTCTCCTTGGAGGGAGGGG	0.527000													32	112					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691769	153691769	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:153691769T>C	ENST00000304337.2	-	2	1208	c.388A>G	c.(388-390)Aat>Gat	p.N130D		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	130	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					AGCCAACCATTACTGCACTTA	0.413000													23	86					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	72994604	72994604	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:72994604T>C	ENST00000308744.6	+	2	700	c.602T>C	c.(601-603)aTg>aCg	p.M201T	NPFFR2_ENST00000358749.3_Missense_Mutation_p.M99T|NPFFR2_ENST00000344413.5_Intron|NPFFR2_ENST00000395999.1_Missense_Mutation_p.M102T	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	201					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			ATATTCTGCATGCCTATAACA	0.368000													30	92					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	645095	645095	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:645095C>A	ENST00000581619.1	+	8	2317	c.1470C>A	c.(1468-1470)acC>acA	p.T490T	CLUL1_ENST00000338387.7_Silent_p.T465T|CLUL1_ENST00000400606.2_Silent_p.T465T|CLUL1_ENST00000579494.1_Silent_p.T465T|C18orf56_ENST00000585033.1_Intron|CLUL1_ENST00000540035.1_Silent_p.T517T			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	465					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						ATTTTAAAACCTGGTAAGCAG	0.388000													16	63					4.14922e-12	4.31867e-12	1	1	0
FRS2	10818	broad.mit.edu	37	12	69968254	69968254	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:69968254A>G	ENST00000299293.2	+	10	1556	c.1046A>G	c.(1045-1047)tAt>tGt	p.Y349C	FRS2_ENST00000397997.2_Missense_Mutation_p.Y349C|FRS2_ENST00000549921.1_Missense_Mutation_p.Y349C|FRS2_ENST00000550389.1_Missense_Mutation_p.Y349C	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	349					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTATTAAACTATGAAAATCTA	0.458000													4	138					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55105247	55105247	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55105247G>A	ENST00000453777.1	+	1	122		c.e1+1		LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000473156.1_Splice_Site|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000251372.3_Splice_Site	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1						cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GACTGCCATGGTAAGGACCCC	0.577000													4	9					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42539506	42539506	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:42539506G>A	ENST00000358097.4	-	0	342				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CTCGCGCACGGCCGCCAGCCC	0.726000													4	6					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73346903	73346903	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:73346903A>G	ENST00000377767.4	-	9	1414	c.1314T>C	c.(1312-1314)gaT>gaC	p.D438D	DIS3_ENST00000545453.1_Silent_p.D276D|DIS3_ENST00000377780.4_Silent_p.D408D	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	438					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		GATGGGGAACATCGTGTTCAA	0.388000										Multiple Myeloma(4;0.011)			29	83					0	0	1	0	0
LINC01317	104355287	broad.mit.edu	37	2	33952131	33952131	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:33952131C>T	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							ACCAGGTGGGCAGAGTACACC	0.552000													6	19					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	16010593	16010593	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:16010593A>T	ENST00000352083.6	-	14	1993	c.1916T>A	c.(1915-1917)aTc>aAc	p.I639N	SOX6_ENST00000316399.6_Missense_Mutation_p.I619N|SOX6_ENST00000528252.1_Missense_Mutation_p.I612N|SOX6_ENST00000396356.3_Missense_Mutation_p.I619N|SOX6_ENST00000527619.1_Missense_Mutation_p.I615N|SOX6_ENST00000528429.1_Missense_Mutation_p.I639N			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	639					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						GGCCTGAAGGATTTTTCTCCT	0.517000											OREG0020800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	184					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45875172	45875172	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:45875172A>G	ENST00000311275.7	-	14	2057	c.1804T>C	c.(1804-1806)Tat>Cat	p.Y602H	ZMYND8_ENST00000458360.2_Missense_Mutation_p.Y597H|ZMYND8_ENST00000461685.1_Missense_Mutation_p.Y622H|ZMYND8_ENST00000355972.4_Missense_Mutation_p.Y602H|ZMYND8_ENST00000446994.2_Missense_Mutation_p.Y539H|ZMYND8_ENST00000352431.2_Missense_Mutation_p.Y622H|ZMYND8_ENST00000471951.2_Missense_Mutation_p.Y622H|ZMYND8_ENST00000360911.3_Missense_Mutation_p.Y597H|ZMYND8_ENST00000262975.4_Missense_Mutation_p.Y602H|ZMYND8_ENST00000372023.3_Missense_Mutation_p.Y597H|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000536340.1_Missense_Mutation_p.Y629H|ZMYND8_ENST00000540497.1_Missense_Mutation_p.Y550H|ZMYND8_ENST00000396281.4_Missense_Mutation_p.Y602H			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	602							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCACTGATATACTCACTATCG	0.418000													48	104					0	0	1	0	0
AAGAB	79719	broad.mit.edu	37	15	67496391	67496391	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:67496391C>T	ENST00000261880.5	-	8	915	c.811G>A	c.(811-813)Gaa>Aaa	p.E271K	AAGAB_ENST00000542650.1_Missense_Mutation_p.E162K|AAGAB_ENST00000538028.1_5'UTR|AAGAB_ENST00000561452.1_Missense_Mutation_p.E162K	NM_001271885.1|NM_001271886.1|NM_024666.3	NP_001258814.1|NP_001258815.1|NP_078942.3	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin binding protein	271					protein transport	cytoplasm				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9						CCTTTCATTTCCTTTAACTTT	0.363000													7	22					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90020655	90020655	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:90020655T>C	ENST00000405460.2	+	46	9851	c.9755T>C	c.(9754-9756)aTg>aCg	p.M3252T		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3252					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCAGGGGGAATGGATGTTGTG	0.299000													49	133					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34850864	34850864	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:34850864C>T	ENST00000420428.2	-	8	1361	c.966G>A	c.(964-966)ccG>ccA	p.P322P	CELF4_ENST00000361795.5_Silent_p.P320P|CELF4_ENST00000412753.1_Silent_p.P321P|CELF4_ENST00000334919.5_Silent_p.P312P|CELF4_ENST00000591282.1_Silent_p.P322P|CELF4_ENST00000603232.1_Silent_p.P321P|CELF4_ENST00000591287.1_Silent_p.P321P|CELF4_ENST00000601019.1_Silent_p.P320P|CELF4_ENST00000588597.1_Silent_p.P311P	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	322					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						CAGTGATGCCCGGAGGGGTGC	0.622000													7	25					0	0	1	0	0
SPATS2	65244	broad.mit.edu	37	12	49888751	49888751	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49888751C>T	ENST00000553127.1	+	8	1005	c.492C>T	c.(490-492)ccC>ccT	p.P164P	SPATS2_ENST00000552918.1_Silent_p.P164P|SPATS2_ENST00000321898.6_Silent_p.P164P|SPATS2_ENST00000552557.1_3'UTR			Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	164						cytoplasm				breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(1)|prostate(1)|urinary_tract(4)	21						TGGAGGATCCCGAGTCTGCCA	0.438000													12	100					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136907048	136907048	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:136907048T>C	ENST00000303407.7	-	8	1426	c.1241A>G	c.(1240-1242)aAg>aGg	p.K414R	BRD3_ENST00000371834.2_Missense_Mutation_p.K414R|BRD3_ENST00000357885.2_Missense_Mutation_p.K414R	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	414						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		ATCTGGCATCTTGGCAAACCT	0.652000			T	C15orf55	lethal midline carcinoma of young people								5	28					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54822643	54822643	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54822643G>A	ENST00000446712.3	-	4	795	c.717C>T	c.(715-717)agC>agT	p.S239S	LILRA5_ENST00000346508.3_Intron|AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000432233.3_Silent_p.S251S|LILRA5_ENST00000301219.3_Intron	NM_181986.2	NP_871715.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AACCTGTCTGGCTTCCCTGAA	0.517000													25	71					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	156979697	156979697	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:156979697T>C	ENST00000348165.5	+	10	1673	c.1313T>C	c.(1312-1314)aTg>aCg	p.M438T	UBE3C_ENST00000389103.4_Missense_Mutation_p.M395T	NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	438					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CAGCACCGCATGATGGTACCC	0.597000													7	20					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140487363	140487363	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:140487363A>G	ENST00000288602.6	-	9	1222	c.1162T>C	c.(1162-1164)Ttt>Ctt	p.F388L		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	388					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCACCACGAAATCCTTGGTCT	0.338000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				16	113					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4925505	4925505	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:4925505G>A	ENST00000320785.5	+	22	2486	c.2129G>A	c.(2128-2130)cGc>cAc	p.R710H	KIF1C_ENST00000573815.1_3'UTR	NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	710					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						ATTGTCAAACGCTGTGGTCTG	0.647000													17	56					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41089339	41089339	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41089339G>T	ENST00000291842.5	+	11	1045	c.996G>T	c.(994-996)gcG>gcT	p.A332A	SHKBP1_ENST00000600733.1_Silent_p.A307A	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	332						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTTATGACGCGGCAGGCTCCT	0.652000													6	11					3.59834e-05	3.66827e-05	1	1	0
UBE4B	10277	broad.mit.edu	37	1	10231324	10231324	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:10231324A>G	ENST00000377157.3	+	24	3788	c.2727A>G	c.(2725-2727)caA>caG	p.Q909Q	UBE4B_ENST00000343090.6_Silent_p.Q1154Q|UBE4B_ENST00000253251.8_Silent_p.Q1025Q	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1154					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TGTTGGACCAACTGACGGATA	0.473000													43	137					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127599186	127599186	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:127599186T>C	ENST00000508053.1	-	69	9097	c.8123A>G	c.(8122-8124)tAc>tGc	p.Y2708C	FBN2_ENST00000262464.4_Missense_Mutation_p.Y2708C			P35556	FBN2_HUMAN	fibrillin 2	2708	EGF-like 47; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGAGCAGCCGTAATTGCAGGG	0.597000													65	188					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221772	140221772	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140221772T>C	ENST00000531613.1	+	1	866	c.866T>C	c.(865-867)gTt>gCt	p.V289A	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.V289A|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACTATGGTTATTGACCAC	0.378000													29	88					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111242	7111242	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:7111242G>A	ENST00000306904.5	+	1	1078	c.891G>A	c.(889-891)ggG>ggA	p.G297G		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	297	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding	p.G297V(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGGACGGGGGACACCGCCAT	0.657000													17	33					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134338061	134338061	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:134338061T>G	ENST00000508956.1	-	7	633	c.576A>C	c.(574-576)aaA>aaC	p.K192N	KY_ENST00000503669.1_Missense_Mutation_p.K213N|KY_ENST00000423778.2_Missense_Mutation_p.K213N|KY_ENST00000508041.1_5'UTR			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	213						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						TGTCAGTGGGTTTGAAGGCTT	0.557000													48	92					0	0	1	0	0
SDHAF2	54949	broad.mit.edu	37	11	61213520	61213520	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:61213520T>C	ENST00000301761.2	+	4	552	c.478T>C	c.(478-480)Tac>Cac	p.Y160H	SDHAF2_ENST00000537782.1_3'UTR|RP11-286N22.8_ENST00000544880.1_Intron|SDHAF2_ENST00000543265.1_3'UTR|RP11-286N22.8_ENST00000543044.1_Missense_Mutation_p.Y148H|SDHAF2_ENST00000542074.1_3'UTR	NM_017841.2	NP_060311.1	Q9NX18	SDHF2_HUMAN	succinate dehydrogenase complex assembly factor 2	160					mitochondrial electron transport, succinate to ubiquinone|protein-FAD linkage	mitochondrion	protein binding			large_intestine(3)|lung(4)|ovary(2)	9						AGATCTTGAGTACCTCTTTGA	0.488000											OREG0021000	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	100					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124911256	124911256	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124911256C>T	ENST00000356219.3	-	12	1395	c.1240G>A	c.(1240-1242)Ggg>Agg	p.G414R	NCOR2_ENST00000429285.2_Missense_Mutation_p.G413R|NCOR2_ENST00000405201.1_Missense_Mutation_p.G414R|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000404621.1_Missense_Mutation_p.G413R|NCOR2_ENST00000397355.1_Missense_Mutation_p.G414R	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	414					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCCATAAGCCCGTTCATGTTG	0.572000													47	82					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60838714	60838714	+	Silent	SNP	C	C	T	rs146206209	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:60838714C>T	ENST00000313733.3	+	4	427	c.225C>T	c.(223-225)agC>agT	p.S75S	OSBPL2_ENST00000358053.2_Silent_p.S63S|OSBPL2_ENST00000439951.2_5'UTR	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	75					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GCGACTTCAGCGTGTGGACCA	0.582000													28	112					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19332077	19332077	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:19332077T>C	ENST00000380432.2	+	13	1680	c.1647T>C	c.(1645-1647)tgT>tgC	p.C549C	DENND4C_ENST00000307015.9_5'UTR|DENND4C_ENST00000602925.1_Silent_p.C785C|DENND4C_ENST00000434457.2_Silent_p.C785C|DENND4C_ENST00000540671.1_Intron	NM_017925.4	NP_060395.5	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	549						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GGTTTATTTGTCTTCCGGCCT	0.383000													21	49					0	0	1	0	0
EME1	146956	broad.mit.edu	37	17	48457820	48457820	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:48457820T>C	ENST00000393271.2	+	8	1615	c.1533T>C	c.(1531-1533)agT>agC	p.S511S	EME1_ENST00000511648.2_Silent_p.S511S|EME1_ENST00000338165.4_Silent_p.S498S	NM_001166131.1	NP_001159603.1	Q96AY2	EME1_HUMAN	essential meiotic structure-specific endonuclease 1	498					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding			endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	19	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			AAATGGCCAGTGCAGTTGTGA	0.622000								Direct reversal of damage;Homologous recombination					15	70					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1841065	1841065	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:1841065G>A	ENST00000415638.3	-	2	1547	c.1468C>T	c.(1468-1470)Cgc>Tgc	p.R490C	IGFALS_ENST00000215539.3_Missense_Mutation_p.R452C	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	452					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						TGGAAGAGGCGGTGGGGCAGG	0.706000													12	23					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76169245	76169245	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:76169245C>A	ENST00000529032.1	+	4	264	c.264C>A	c.(262-264)agC>agA	p.S88R	C11orf30_ENST00000343878.3_Missense_Mutation_p.S88R|C11orf30_ENST00000525919.1_Missense_Mutation_p.S88R|C11orf30_ENST00000525959.1_3'UTR|C11orf30_ENST00000533248.1_Missense_Mutation_p.S102R|C11orf30_ENST00000524490.1_Missense_Mutation_p.S88R|C11orf30_ENST00000524767.1_Missense_Mutation_p.S102R|C11orf30_ENST00000334736.3_Missense_Mutation_p.S88R|C11orf30_ENST00000525038.1_Missense_Mutation_p.S102R			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	88	ENT.|Interaction with BRCA2.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						GACCTAATAGCTCTTCAGAAT	0.408000													21	100					6.33239e-15	6.63078e-15	1	1	0
CNOT8	9337	broad.mit.edu	37	5	154250343	154250343	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:154250343T>C	ENST00000517876.1	+	5	910	c.434T>C	c.(433-435)gTg>gCg	p.V145A	CNOT8_ENST00000523698.1_Missense_Mutation_p.V39A|CNOT8_ENST00000524105.1_Intron|CNOT8_ENST00000519404.1_Intron|CNOT8_ENST00000521450.1_Missense_Mutation_p.V39A|CNOT8_ENST00000521583.1_Missense_Mutation_p.V39A|CNOT8_ENST00000403027.2_Missense_Mutation_p.V145A|CNOT8_ENST00000285896.6_Missense_Mutation_p.V145A|CNOT8_ENST00000520671.1_Missense_Mutation_p.V39A			Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	145					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	10	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACATCAGGAGTGGTTCTCTGT	0.443000													54	128					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49425038	49425038	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49425038G>A	ENST00000301067.7	-	39	13449	c.13450C>T	c.(13450-13452)Cga>Tga	p.R4484*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		ATCTCAGCTCGCAGCCCCTCG	0.597000													96	128					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365563	30365563	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30365563C>A	ENST00000305596.3	-	3	334	c.159G>T	c.(157-159)gaG>gaT	p.E53D	CD2BP2_ENST00000569466.1_Missense_Mutation_p.E53D	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	53					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding	p.E53D(2)		breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						CATCATCATCCTCCTCCTCAT	0.517000													97	324					3.71036e-49	3.93822e-49	1	1	0
GLUD2	2747	broad.mit.edu	37	X	120182040	120182040	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:120182040A>T	ENST00000328078.1	+	1	579	c.502A>T	c.(502-504)Atg>Ttg	p.M168L		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	168					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	GGCTTCTCTGATGACATACAA	0.488000													41	46					0	0	1	0	0
AGAP6	414189	broad.mit.edu	37	10	51754188	51754188	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:51754188A>G	ENST00000374056.4	+	3	724	c.327_splice	c.e3+1	p.H109_splice	AGAP6_ENST00000412531.3_Splice_Site_p.H132_splice			C9IYN2	C9IYN2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6	132					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.H132R(4)		NS(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(8)|prostate(3)|skin(1)|stomach(2)	29						TGTACAAACCATGTAAGTAAA	0.299000													4	58					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17084409	17084409	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:17084409T>C	ENST00000418129.2	+	4	3149	c.2684T>C	c.(2683-2685)gTa>gCa	p.V895A	PLCL2-AS1_ENST00000414844.2_RNA|PLCL2_ENST00000432376.1_Missense_Mutation_p.V895A|PLCL2_ENST00000396755.2_Missense_Mutation_p.V895A	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1021					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GCAGATGCTGTATATGAAAAG	0.393000													4	215					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148975579	148975579	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:148975579G>A	ENST00000434415.1	+	5	926	c.763G>A	c.(763-765)Gac>Aac	p.D255N	ZNF783_ENST00000489518.1_3'UTR	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	255					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GCAGCAGCAGGACTCAGAGGC	0.637000													12	28					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	96996134	96996134	+	Silent	SNP	G	G	A	rs73757900	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:96996134G>A	ENST00000369278.4	+	13	1563	c.1497G>A	c.(1495-1497)tcG>tcA	p.S499S		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	499					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										AGTTTATTTCGGAACTTGCTG	0.299000													4	31					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47947813	47947813	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:47947813G>A	ENST00000289672.2	-	9	1313	c.1263C>T	c.(1261-1263)aaC>aaT	p.N421N		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	421					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CATGAAACTCGTTATAAATAA	0.408000													22	51					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120903814	120903814	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:120903814A>G	ENST00000263713.5	+	20	1956	c.1742A>G	c.(1741-1743)gAt>gGt	p.D581G	EPB41L5_ENST00000452780.1_Missense_Mutation_p.D581G|EPB41L5_ENST00000443902.2_Missense_Mutation_p.D581G	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	581						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						ACAAAAGAAGATAGCTTATTA	0.294000													7	19					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48173142	48173142	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:48173142C>T	ENST00000311303.3	-	5	1108	c.763G>A	c.(763-765)Gcc>Acc	p.A255T	ABCC12_ENST00000416054.1_Missense_Mutation_p.A255T|ABCC12_ENST00000448542.1_Missense_Mutation_p.A255T	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	255	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ATGAAAAAGGCGTACGCCGCA	0.473000													5	163					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129866425	129866425	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:129866425A>G	ENST00000254667.3	+	12	1161	c.882A>G	c.(880-882)tcA>tcG	p.S294S	PTPRE_ENST00000430713.2_3'UTR|PTPRE_ENST00000419012.2_Silent_p.S294S|PTPRE_ENST00000306042.5_Silent_p.S236S	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	294	Tyrosine-protein phosphatase 1.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GGCTGGTCTCACAGCTGCACT	0.617000													34	89					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322842	79322842	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:79322842T>C	ENST00000428286.1	-	8	4471	c.3271A>G	c.(3271-3273)Atg>Gtg	p.M1091V	PRUNE2_ENST00000376718.3_Missense_Mutation_p.M1450V			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1450					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTGAAATTCATCCCATCTGAA	0.423000													31	71					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540844	40540844	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40540844A>G	ENST00000434248.1	-	5	1987	c.1922T>C	c.(1921-1923)tTt>tCt	p.F641S	ZNF780B_ENST00000221355.6_Missense_Mutation_p.F493S	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	641					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTTACATTTAAATGGCTTCTC	0.408000													5	200					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5627482	5627482	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:5627482T>C	ENST00000310917.2	-	13	2531	c.1800A>G	c.(1798-1800)ctA>ctG	p.L600L	EVC2_ENST00000344408.5_Silent_p.L680L|EVC2_ENST00000344938.1_Silent_p.L680L	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	680						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						ATACCTTTTGTAGCAACTCTC	0.388000													22	53					0	0	1	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342347	94342347	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:94342347G>A	ENST00000436063.2	-	2	1201	c.1144C>T	c.(1144-1146)Ccc>Tcc	p.P382S	DNTTIP2_ENST00000460191.1_5'UTR	NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		GCTTTTATGGGGCTCTTTTTG	0.393000													4	220					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70858308	70858308	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:70858308T>C	ENST00000358731.4	+	38	7967	c.7704T>C	c.(7702-7704)atT>atC	p.I2568I	BDP1_ENST00000380675.2_3'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2568					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAAGTGTTATTACTACTCAAT	0.353000													21	47					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122664230	122664230	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:122664230G>A	ENST00000263461.6	+	25	3346	c.3100G>A	c.(3100-3102)Gcc>Acc	p.A1034T	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	1034						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TTCACTGAAAGCCTGTTTAGT	0.443000													4	112					0	0	1	0	0
DES	1674	broad.mit.edu	37	2	220284873	220284873	+	Missense_Mutation	SNP	G	G	A	rs144261171		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:220284873G>A	ENST00000373960.3	+	2	721	c.635G>A	c.(634-636)cGa>cAa	p.R212Q		NM_001927.3	NP_001918.3	P17661	DESM_HUMAN	desmin	212	Coil 1B.|Rod.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton	p.R212Q(1)		breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)	18		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCTGCCTTCCGAGCGGTGAGT	0.577000													29	84					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748329	68748329	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:68748329C>T	ENST00000309106.3	-	1	126	c.127G>A	c.(127-129)Gca>Aca	p.A43T		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	43						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTGTTGCCTGCCATCCCGCAC	0.592000													16	66					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922233	24922233	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:24922233A>G	ENST00000329468.2	+	1	1693	c.1219A>G	c.(1219-1221)Acc>Gcc	p.T407A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ACCTGTGCAGACCACAGACTC	0.537000													21	62					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1064202	1064202	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:1064202T>C	ENST00000264930.5	-	19	2646	c.2603A>G	c.(2602-2604)cAc>cGc	p.H868R		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	868					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCCCACCTTGTGCTGGCGCAG	0.716000													7	36					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43663574	43663574	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43663574G>A	ENST00000564079.1	+	1	262	c.22G>A	c.(22-24)Gct>Act	p.A8T	TUBGCP4_ENST00000570081.1_Intron|TUBGCP4_ENST00000260383.7_Missense_Mutation_p.A8T	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	8					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		ACTGCTCTTGGCTCTGAGCGG	0.647000											OREG0023087	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	25					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9967507	9967507	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9967507C>T	ENST00000264833.4	-	5	848	c.663G>A	c.(661-663)acG>acA	p.T221T	OLFM2_ENST00000590841.1_Silent_p.T143T	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	221	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						TGGGGGCCATCGTGTCAGTCA	0.662000													10	22					0	0	1	0	0
BANP	54971	broad.mit.edu	37	16	88052189	88052189	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:88052189G>A	ENST00000393207.1	+	7	1008	c.787G>A	c.(787-789)Gag>Aag	p.E263K	BANP_ENST00000286122.7_Missense_Mutation_p.E263K|BANP_ENST00000355163.5_Missense_Mutation_p.E238K|BANP_ENST00000538234.1_Missense_Mutation_p.E271K|BANP_ENST00000393208.2_Missense_Mutation_p.E232K|BANP_ENST00000479780.2_Missense_Mutation_p.E232K|BANP_ENST00000355022.4_Missense_Mutation_p.E232K	NM_001173543.1	NP_001167014.1	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein	263	BEN.|Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.00551)		CTTCCACCGCGAGGTGCAGGC	0.652000													5	19					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40186267	40186267	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:40186267T>C	ENST00000360214.3	+	5	715	c.255T>C	c.(253-255)gcT>gcC	p.A85A	ETS2_ENST00000360938.3_Silent_p.A85A	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	85	PNT.				positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CCTTAAAAGCTACCTTCAGTG	0.512000													34	90					0	0	1	0	0
CECR1	51816	broad.mit.edu	37	22	17662422	17662422	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:17662422A>T	ENST00000399839.1	-	10	1757	c.1487T>A	c.(1486-1488)aTc>aAc	p.I496N	CECR1_ENST00000330232.4_Missense_Mutation_p.I255N|CECR1_ENST00000262607.3_Missense_Mutation_p.I496N|CECR1_ENST00000399837.2_Missense_Mutation_p.I496N|CECR1_ENST00000449907.2_Missense_Mutation_p.I454N			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	496					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				CTTCTTCCAGATTTCCATGAA	0.522000													9	332					0	0	1	0	0
CDAN1	146059	broad.mit.edu	37	15	43023206	43023206	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43023206A>G	ENST00000356231.3	-	13	1947	c.1924T>C	c.(1924-1926)Ttt>Ctt	p.F642L		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	642						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		AAAGCCACAAAGCCCAGGAAT	0.562000													37	112					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47601376	47601376	+	Splice_Site	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:47601376C>A	ENST00000371917.4	+	15	2069	c.2070_splice	c.e15+1	p.S690_splice		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	690	SEC7.				exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity	p.S690F(1)		breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CGCCTGGATTCCGTAAGGCTT	0.527000													35	119					3.90053e-15	4.08622e-15	1	1	0
SLITRK1	114798	broad.mit.edu	37	13	84453776	84453776	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:84453776C>A	ENST00000377084.2	-	1	2752	c.1867G>T	c.(1867-1869)Gga>Tga	p.G623*		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	623						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AGCAGCAGTCCCGGGACCAAC	0.577000													8	29					0.00307968	0.00310584	1	1	0
TYK2	7297	broad.mit.edu	37	19	10464742	10464742	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10464742A>G	ENST00000525621.1	-	20	3365	c.2884T>C	c.(2884-2886)Tac>Cac	p.Y962H	TYK2_ENST00000524462.1_Missense_Mutation_p.Y777H|TYK2_ENST00000264818.6_Missense_Mutation_p.Y962H	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	962	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CAGCCCTTGTACTTGATGATG	0.647000													37	82					0	0	1	0	0
POU2F1	5451	broad.mit.edu	37	1	167384807	167384807	+	Silent	SNP	G	G	A	rs34658638	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:167384807G>A	ENST00000367862.5	+	16	2263	c.2028G>A	c.(2026-2028)gcG>gcA	p.A676A	POU2F1_ENST00000429375.2_Silent_p.A624A|POU2F1_ENST00000367866.2_Silent_p.A687A|POU2F1_ENST00000420254.3_Intron|POU2F1_ENST00000367865.1_3'UTR|POU2F1_ENST00000541643.3_Silent_p.A664A	NM_001198783.1	NP_001185712.1	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	664					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	30						TTGCCAATGCGGGAGGAGCCC	0.547000													13	127					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36122906	36122906	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:36122906C>T	ENST00000377966.3	+	21	3346	c.2780C>T	c.(2779-2781)tCt>tTt	p.S927F		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	927						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GTCCCTCTCTCTGCCCTCATC	0.552000													6	165					0	0	1	0	0
TNNI2	7136	broad.mit.edu	37	11	1862298	1862298	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1862298G>C	ENST00000381906.1	+	7	383	c.314G>C	c.(313-315)gGc>gCc	p.G105A	TNNI2_ENST00000252898.7_Missense_Mutation_p.G105A|TNNI2_ENST00000381905.3_Missense_Mutation_p.G105A|TNNI2_ENST00000381911.1_Missense_Mutation_p.G105A	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	105	Involved in binding TNC and actin.				muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GATCTGCGGGGCAAGTTCAAG	0.677000													9	32					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31297440	31297440	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:31297440A>G	ENST00000265071.2	+	4	833	c.568A>G	c.(568-570)Aca>Gca	p.T190A	CDH6_ENST00000514738.1_Missense_Mutation_p.T135A	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	190	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGATGATCCAACATATGGGAA	0.368000													24	72					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161021404	161021404	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:161021404G>A	ENST00000368013.3	-	10	1440	c.1120C>T	c.(1120-1122)Cct>Tct	p.P374S	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.P197S|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.P374S	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	374					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TCTGCCTCAGGCTCCTGTTCA	0.652000													34	85					0	0	1	0	0
BTBD7	55727	broad.mit.edu	37	14	93712550	93712550	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:93712550A>G	ENST00000334746.5	-	10	2511	c.2204T>C	c.(2203-2205)gTa>gCa	p.V735A	BTBD7_ENST00000554565.1_Missense_Mutation_p.V384A|BTBD7_ENST00000393170.2_Missense_Mutation_p.V309A	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	735										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		TGTACTGTTTACGCGACATCT	0.473000													53	202					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22929841	22929841	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:22929841A>G	ENST00000313077.7	+	6	640	c.515A>G	c.(514-516)gAc>gGc	p.D172G	CYFIP1_ENST00000560848.1_Missense_Mutation_p.D172G	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	172					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GCTGTGCTGGACGAGCTGAAG	0.577000													6	71					0	0	1	0	0
NCALD	83988	broad.mit.edu	37	8	102701613	102701613	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:102701613A>G	ENST00000395923.1	-	6	965	c.506T>C	c.(505-507)tTc>tCc	p.F169S	NCALD_ENST00000522951.1_Intron|NCALD_ENST00000311028.3_Missense_Mutation_p.F169S|NCALD_ENST00000220931.6_Missense_Mutation_p.F169S|NCALD_ENST00000519508.2_Missense_Mutation_p.F169S|NCALD_ENST00000521599.1_Missense_Mutation_p.F169S	NM_001040627.1|NM_001040628.1|NM_001040629.1|NM_001040630.1	NP_001035717.1|NP_001035718.1|NP_001035719.1|NP_001035720.1	P61601	NCALD_HUMAN	neurocalcin delta	169	EF-hand 4.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			TCCTCGGATGAACTCTTCCAG	0.602000													6	24					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126724000	126724000	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:126724000C>T	ENST00000393409.2	+	6	1811	c.1811C>T	c.(1810-1812)aCg>aTg	p.T604M	PLXNA1_ENST00000251772.4_Missense_Mutation_p.T581M	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	604					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GAGGACTTCACGGAATCTGAG	0.672000													14	31					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96069102	96069102	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:96069102T>C	ENST00000297954.4	+	27	6369	c.6370_splice	c.e27+1	p.S2123_splice	WNK2_ENST00000395477.2_Splice_Site_p.S2086_splice|WNK2_ENST00000427277.2_Splice_Site_p.S1698_splice|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Splice_Site_p.S1735_splice|WNK2_ENST00000356055.3_3'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2123					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						AACACAGCAGTAGTAATTATC	0.567000													5	303					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23079773	23079773	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:23079773T>C	ENST00000219689.7	-	16	3652	c.3653A>G	c.(3652-3654)gAc>gGc	p.D1218G	USP31_ENST00000567975.1_Missense_Mutation_p.D511G	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1218	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		AGACTTGCTGTCCCTCTTCAA	0.612000													4	216					0	0	1	0	0
HSPA12A	259217	broad.mit.edu	37	10	118434729	118434729	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:118434729G>A	ENST00000369209.3	-	12	1695	c.1591C>T	c.(1591-1593)Cgc>Tgc	p.R531C		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	531							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		GGCGACCGGCGCACCTTGATG	0.652000													27	55					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14040401	14040401	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14040401T>C	ENST00000318003.7	+	26	2879	c.2638T>C	c.(2638-2640)Tac>Cac	p.Y880H	CC2D1A_ENST00000589606.1_Missense_Mutation_p.Y879H	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	880					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GGCCCAGCAGTACCAGGACAT	0.662000													3	26					0	0	1	0	0
ZBTB6	10773	broad.mit.edu	37	9	125673354	125673354	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:125673354T>C	ENST00000373659.3	-	2	1086	c.998A>G	c.(997-999)aAa>aGa	p.K333R		NM_006626.5	NP_006617.1	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	11						TGTAAATGTTTTTCCGCACTG	0.448000													5	116					0	0	1	0	0
HDAC2	3066	broad.mit.edu	37	6	114270368	114270368	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:114270368A>T	ENST00000519065.1	-	7	1072	c.696T>A	c.(694-696)ggT>ggA	p.G232G	HDAC2_ENST00000368632.2_Silent_p.G202G|HDAC2_ENST00000519108.1_Silent_p.G202G|HDAC2_ENST00000398283.2_Silent_p.G326G			Q92769	HDAC2_HUMAN	histone deacetylase 2	232	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	CATCATCTATACCATCTCTCA	0.303000													23	46					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124330404	124330404	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124330404T>C	ENST00000409039.3	+	30	5289	c.5264T>C	c.(5263-5265)tTc>tCc	p.F1755S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1755	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GTTGATTCTTTCATAAGAGGC	0.468000													47	214					0	0	1	0	0
SETMAR	6419	broad.mit.edu	37	3	4355021	4355021	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:4355021A>G	ENST00000358065.4	+	2	663	c.596A>G	c.(595-597)cAt>cGt	p.H199R	SETMAR_ENST00000430981.1_Missense_Mutation_p.H199R|SETMAR_ENST00000425863.1_Intron|SUMF1_ENST00000534863.1_Intron	NM_006515.3	NP_006506.3	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion gene	186	Histone-lysine N-methyltransferase.|SET.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		ATCAGGGAACATGTTTATAAT	0.358000								Chromatin Structure					9	90					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811044	23811044	+	Missense_Mutation	SNP	G	G	A	rs151216955		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:23811044G>A	ENST00000314520.3	+	1	591	c.115G>A	c.(115-117)Ggg>Agg	p.G39R	MKRN3_ENST00000568252.1_Missense_Mutation_p.G39R|MKRN3_ENST00000564592.1_Missense_Mutation_p.G39R	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	39						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TGAGCCCTCCGGGGAATCTGC	0.687000													15	42					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5348802	5348802	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:5348802G>A	ENST00000399537.4	-	28	8934	c.8586C>T	c.(8584-8586)ccC>ccT	p.P2862P	TNRC18_ENST00000430969.1_Silent_p.P2862P			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2862	BAH.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TGGTCTCCTCGGGGTGGTAGA	0.692000													12	46					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21677247	21677247	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21677247G>A	ENST00000328843.6	+	27	4790	c.4759G>A	c.(4759-4761)Gcc>Acc	p.A1587T	DNAH11_ENST00000409508.3_Missense_Mutation_p.A1582T			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1587	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GTTCAAGACAGCCAAAGTAGA	0.318000									Kartagener syndrome				3	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179458948	179458948	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179458948T>C	ENST00000589042.1	-	297	58396	c.58172A>G	c.(58171-58173)gAc>gGc	p.D19391G	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D10326G|TTN_ENST00000342992.6_Missense_Mutation_p.D16823G|TTN_ENST00000591111.1_Missense_Mutation_p.D17750G|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D10451G|TTN_ENST00000342175.6_Missense_Mutation_p.D10518G|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17750	Fibronectin type-III 40.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCTGAAGTCGAGGTGAAG	0.403000													5	81					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18022349	18022349	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:18022349G>A	ENST00000205890.5	+	2	573	c.235G>A	c.(235-237)Gtg>Atg	p.V79M		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	79	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GGCCCGCACCGTGCTCAAGTC	0.617000													7	23					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6436589	6436589	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6436589C>T	ENST00000449001.2	+	14	2238	c.1744C>T	c.(1744-1746)Cgg>Tgg	p.R582W	PLEKHG6_ENST00000396988.3_Missense_Mutation_p.R614W|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.R614W|PLEKHG6_ENST00000304581.8_Missense_Mutation_p.R144W	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	614					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						AAGAGCCCTTCGGCGGGACCC	0.667000													50	226					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815539	44815539	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44815539C>G	ENST00000372262.3	-	8	1871	c.1471G>C	c.(1471-1473)Gat>Cat	p.D491H	CDH22_ENST00000537909.1_Missense_Mutation_p.D491H	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	491	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TCGTTCACATCCAGGATTCGG	0.577000													62	230					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146798109	146798109	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:146798109C>T	ENST00000343218.5	-	3	753	c.556G>A	c.(556-558)Gtc>Atc	p.V186I	DPYSL3_ENST00000534907.1_Intron|DPYSL3_ENST00000398514.3_Missense_Mutation_p.V72I	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	72					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGTATGGACATCGATGCCT	0.483000													53	160					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142571233	142571233	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:142571233C>A	ENST00000359396.3	-	13	2001	c.1756G>T	c.(1756-1758)Gcc>Tcc	p.A586S		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	586					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CGCTCATGGGCCACTCGCCAG	0.592000													50	121					1.86633e-21	1.97029e-21	1	1	0
ARHGEF16	27237	broad.mit.edu	37	1	3395015	3395015	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:3395015C>T	ENST00000378378.4	+	12	2058	c.1653C>T	c.(1651-1653)taC>taT	p.Y551Y	ARHGEF16_ENST00000378373.1_Silent_p.Y263Y|ARHGEF16_ENST00000378371.2_Silent_p.Y263Y|ARHGEF16_ENST00000413250.2_Silent_p.Y255Y	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	551	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TCCAGGACTACGCCCAGATGA	0.662000													52	111					0	0	1	0	0
ZMYM2	7750	broad.mit.edu	37	13	20567602	20567602	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:20567602G>A	ENST00000382869.3	+	3	641	c.390G>A	c.(388-390)ggG>ggA	p.G130G	ZMYM2_ENST00000382871.2_Silent_p.G130G|ZMYM2_ENST00000382874.2_Silent_p.G130G|ZMYM2_ENST00000382881.3_Silent_p.G130G	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAAATCAAGGGCAAGAGAAAA	0.383000													16	67					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4086789	4086789	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:4086789A>G	ENST00000341657.4	-	14	1891	c.1856T>C	c.(1855-1857)aTg>aCg	p.M619T	ANKFY1_ENST00000570535.1_Missense_Mutation_p.M661T|CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000574367.1_Missense_Mutation_p.M619T	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	619						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CCCATCCGACATGGTGTCATT	0.592000													35	86					0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8577283	8577283	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:8577283T>C	ENST00000393927.4	-	4	631	c.518A>G	c.(517-519)aAt>aGt	p.N173S	ZNF414_ENST00000255616.8_Missense_Mutation_p.N173S	NM_001146175.1	NP_001139647.1	Q96IQ9	ZN414_HUMAN	zinc finger protein 414	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						GAAGTAGCGATTGGGTTTGTA	0.602000													22	73					0	0	1	0	0
SMPD1	6609	broad.mit.edu	37	11	6412943	6412943	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:6412943G>A	ENST00000342245.4	+	2	816	c.648G>A	c.(646-648)ctG>ctA	p.L216L	SMPD1_ENST00000527275.1_Silent_p.L215L|SMPD1_ENST00000356761.2_Silent_p.L216L|SMPD1_ENST00000299397.3_Silent_p.L216L|SMPD1_ENST00000533196.1_Intron	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	214					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	ATGACTACCTGGAGGGCACGG	0.682000													10	54					0	0	1	0	0
PELP1	27043	broad.mit.edu	37	17	4576371	4576371	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:4576371G>A	ENST00000301396.4	-	16	2572	c.2347C>T	c.(2347-2349)Cag>Tag	p.Q783*	PELP1_ENST00000574876.1_Nonsense_Mutation_p.Q639*|PELP1_ENST00000572293.1_Nonsense_Mutation_p.Q689*|PELP1_ENST00000436683.2_Nonsense_Mutation_p.Q492*|PELP1_ENST00000269230.7_Nonsense_Mutation_p.Q551*			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	639	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						CCCATGGGCTGCAGGGGAGGA	0.652000													15	29					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102142891	102142891	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:102142891A>G	ENST00000299314.7	-	20	3943	c.3681T>C	c.(3679-3681)ttT>ttC	p.F1227F		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	1227					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						GCTCAGCAAAAAATGAGAATA	0.323000													19	119					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16478291	16478291	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:16478291A>T	ENST00000354981.2	-	11	1366	c.1209T>A	c.(1207-1209)agT>agA	p.S403R	KIF16B_ENST00000355755.3_Missense_Mutation_p.S403R|KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000408042.1_Missense_Mutation_p.S403R	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	403					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TTTCCTCCATACTTAAAGCTG	0.303000													7	56					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133393322	133393322	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133393322C>G	ENST00000204726.3	-	3	768	c.210G>C	c.(208-210)ggG>ggC	p.G70G	GOLGA3_ENST00000545875.1_Silent_p.G70G|GOLGA3_ENST00000456883.2_Silent_p.G70G|GOLGA3_ENST00000450791.2_Silent_p.G70G|GOLGA3_ENST00000537452.1_Silent_p.G70G	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	70	Pro-rich.		G -> E (in dbSNP:rs2291256).		intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GTGGCGTTGGCCCGTTCTGAC	0.627000													5	87					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129096403	129096403	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:129096403C>T	ENST00000249344.2	+	9	998	c.958C>T	c.(958-960)Ccc>Tcc	p.P320S	STRIP2_ENST00000435494.2_Missense_Mutation_p.P320S	NM_020704.2	NP_065755.1			striatin interacting protein 2																		TGCCTCCCCGCCCTCTTACAC	0.597000													37	78					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102590878	102590878	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:102590878G>A	ENST00000330847.1	+	2	631	c.587G>A	c.(586-588)gGc>gAc	p.G196D	NR4A3_ENST00000395097.2_Missense_Mutation_p.G185D|NR4A3_ENST00000338488.4_Missense_Mutation_p.G185D			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	185					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				ACGGTGGCCGGCGCGCGCTTC	0.776000			T	EWSR1	extraskeletal myxoid chondrosarcoma								5	5					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182780567	182780567	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:182780567C>G	ENST00000431877.2	+	11	2379	c.2200C>G	c.(2200-2202)Cta>Gta	p.L734V	SSFA2_ENST00000320370.7_Missense_Mutation_p.L734V|SSFA2_ENST00000409001.1_Missense_Mutation_p.L734V|SSFA2_ENST00000428267.2_Missense_Mutation_p.L581V|SSFA2_ENST00000409136.1_Missense_Mutation_p.L243V	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	734						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TGGCTATCCTCTAAGAAGGTC	0.423000													27	107					0	0	1	0	0
SFPQ	6421	broad.mit.edu	37	1	35653605	35653605	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35653605T>C	ENST00000357214.5	-	7	1882	c.1784A>G	c.(1783-1785)gAa>gGa	p.E595G		NM_005066.2	NP_005057.1	P23246	SFPQ_HUMAN	splicing factor proline/glutamine-rich	595					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|RNA binding		SFPQ/TFE3(6)	NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GCTGTAACTTTCCTCTCTTTG	0.453000			T	TFE3	papillary renal cell								40	155					0	0	1	0	0
AP5M1	55745	broad.mit.edu	37	14	57747082	57747082	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:57747082A>G	ENST00000261558.3	+	3	1296	c.890A>G	c.(889-891)tAc>tGc	p.Y297C	AP5M1_ENST00000556723.1_3'UTR|AP5M1_ENST00000431972.2_Missense_Mutation_p.Y311C	NM_018229.3	NP_060699.3	Q9H0R1	MUDEN_HUMAN	adaptor-related protein complex 5, mu 1 subunit	297	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex											AGTGGGCCTTACAAATTTCCA	0.388000													32	101					0	0	1	0	0
YAP1	10413	broad.mit.edu	37	11	102094469	102094469	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:102094469T>A	ENST00000282441.5	+	7	1537	c.1149T>A	c.(1147-1149)gaT>gaA	p.D383E	YAP1_ENST00000531439.1_Missense_Mutation_p.D367E|YAP1_ENST00000537274.1_Missense_Mutation_p.D371E|YAP1_ENST00000524575.1_Missense_Mutation_p.D205E|YAP1_ENST00000345877.2_Missense_Mutation_p.D333E|YAP1_ENST00000526343.1_Missense_Mutation_p.D329E	NM_001130145.2	NP_001123617.1	P46937	YAP1_HUMAN	Yes-associated protein 1	383	Transactivation domain.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)	4	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		ATAGCTCAGATCCTTTCCTTA	0.433000													26	62					0	0	1	0	0
AGPAT6	137964	broad.mit.edu	37	8	41467239	41467239	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:41467239A>G	ENST00000396987.3	+	4	1228	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	RP11-360L9.8_ENST00000581909.1_RNA	NM_178819.3	NP_848934.1	Q86UL3	GPAT4_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 6	101					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			AAGTGGTAGTAGTAAGGCTCT	0.453000													35	152					0	0	1	0	0
IGHV3-38	28429	broad.mit.edu	37	14	106866531	106866531	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:106866531T>C	ENST00000390618.2	-	0	300																											GCGTAGTATGTGCTACCACCA	0.532000													7	312					0	0	1	0	0
ALDOC	230	broad.mit.edu	37	17	26900911	26900911	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:26900911A>G	ENST00000226253.4	-	8	1316	c.841T>C	c.(841-843)Tca>Cca	p.S281P	RP11-192H23.5_ENST00000585189.1_RNA|ALDOC_ENST00000395319.3_Missense_Mutation_p.S253P|ALDOC_ENST00000395321.2_Missense_Mutation_p.S281P	NM_005165.2	NP_005156.1	P09972	ALDOC_HUMAN	aldolase C, fructose-bisphosphate	281					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Lung NSC(42;0.00431)					AGGTTGAATGATGCCTCTTCT	0.562000													4	134					0	0	1	0	0
NOLC1	9221	broad.mit.edu	37	10	103919045	103919045	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:103919045G>A	ENST00000405356.1	+	6	938	c.703G>A	c.(703-705)Gca>Aca	p.A235T	NOLC1_ENST00000488254.2_Missense_Mutation_p.A236T|NOLC1_ENST00000603742.1_5'UTR|NOLC1_ENST00000605788.1_Missense_Mutation_p.A235T			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	235	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		GGAGGAGAAGGCAGCAGCCAC	0.547000													32	157					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24479268	24479268	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:24479268T>C	ENST00000398319.2	+	20	3221	c.2836T>C	c.(2836-2838)Tgc>Cgc	p.C946R	CABIN1_ENST00000263119.5_Missense_Mutation_p.C946R|CABIN1_ENST00000405822.2_Missense_Mutation_p.C896R	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	946					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CTTGGAGCAGTGCTTCTACTG	0.582000													18	29					0	0	1	0	0
DTX4	23220	broad.mit.edu	37	11	58949498	58949498	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:58949498G>A	ENST00000227451.3	+	2	602	c.498G>A	c.(496-498)ggG>ggA	p.G166G	DTX4_ENST00000532982.1_Silent_p.G60G	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	166					Notch signaling pathway	cytoplasm	zinc ion binding	p.G60G(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				TGGTCACAGGGACCTTGCCTA	0.637000													23	79					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208795811	208795811	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:208795811G>A	ENST00000457206.1	-	5	2152	c.1725C>T	c.(1723-1725)taC>taT	p.Y575Y	PLEKHM3_ENST00000427836.2_Silent_p.Y575Y|PLEKHM3_ENST00000389247.4_Silent_p.Y575Y			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	575					intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CTTCGTACACGTACTCCAGAA	0.602000													32	88					0	0	1	0	0
OXCT2	64064	broad.mit.edu	37	1	40235542	40235542	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:40235542G>A	ENST00000327582.5	-	1	1478	c.1386C>T	c.(1384-1386)tgC>tgT	p.C462C	BMP8B_ENST00000372827.3_Intron|BMP8B_ENST00000397360.2_Intron	NM_022120.1	NP_071403.1	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2	462					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|pancreas(1)|upper_aerodigestive_tract(1)	6	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	TGCGGTCCACGCACCGCTTCC	0.587000													12	67					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8138525	8138525	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:8138525C>T	ENST00000315684.8	-	8	1292	c.1285G>A	c.(1285-1287)Gtt>Att	p.V429I		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	429					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						TGAAGCAGAACGGCGCCACGG	0.612000													31	89					0	0	1	0	0
ZNF624	57547	broad.mit.edu	37	17	16526165	16526165	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:16526165T>C	ENST00000311331.7	-	6	2126	c.2035A>G	c.(2035-2037)Aat>Gat	p.N679D		NM_020787.3	NP_065838.2	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	679					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	26				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGTGATGTATTAGTGAAGGCT	0.388000													35	94					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22068689	22068689	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:22068689A>G	ENST00000261200.4	-	5	728	c.729T>C	c.(727-729)atT>atC	p.I243I	ABCC9_ENST00000345162.2_Silent_p.I243I|ABCC9_ENST00000261201.4_Silent_p.I243I	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	243					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCTTCAGATCAATAGGCTTTT	0.368000													26	113					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47859533	47859533	+	Missense_Mutation	SNP	G	G	A	rs138729543		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:47859533G>A	ENST00000445061.1	+	4	457	c.50G>A	c.(49-51)cGt>cAt	p.R17H	DHX30_ENST00000476446.1_3'UTR|DHX30_ENST00000348968.4_5'UTR|DHX30_ENST00000446256.2_5'UTR	NM_138615.2	NP_619520.1	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	17						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding	p.R17H(1)		endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		cacaggcagcgtcagtgcaaa	0.607000													78	204					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61654228	61654228	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:61654228C>T	ENST00000397985.2	+	7	1097	c.841C>T	c.(841-843)Cct>Tct	p.P281S	SERPINB8_ENST00000353706.2_Missense_Mutation_p.P281S|SERPINB8_ENST00000542677.1_Missense_Mutation_p.P99S|SERPINB8_ENST00000493661.1_Intron	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	281					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				TGACTTGGAGCCTTTCCTTCG	0.418000													29	89					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53859936	53859936	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:53859936C>T	ENST00000471389.1	+	3	506	c.284C>T	c.(283-285)tCt>tTt	p.S95F	FTO_ENST00000394647.3_Intron	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	95	Fe2OG dioxygenase domain.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						ACTCCGGTATCTCGCATCCTC	0.493000													23	76					0	0	1	0	0
ZNF718	255403	broad.mit.edu	37	4	155055	155055	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:155055A>G	ENST00000510175.1	+	0	490							Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		AAGAATTCATACTGGAGAGAA	0.358000													13	41					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60885589	60885589	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:60885589G>A	ENST00000252999.3	-	76	10552	c.10486C>T	c.(10486-10488)Ctg>Ttg	p.L3496L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3496	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCCGTGCAGCCTCAGTCTC	0.687000													41	107					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40397459	40397459	+	Missense_Mutation	SNP	C	C	G	rs148383040		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:40397459C>G	ENST00000542756.1	-	6	2008	c.1985G>C	c.(1984-1986)aGa>aCa	p.R662T	SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1_ENST00000408028.2_Missense_Mutation_p.R659T|SLC8A1_ENST00000406391.2_Intron|SLC8A1_ENST00000405269.1_Intron|SLC8A1_ENST00000402441.1_Intron|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1_ENST00000332839.4_Missense_Mutation_p.R667T|SLC8A1_ENST00000403092.1_Missense_Mutation_p.R667T|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542024.1_Intron|SLC8A1_ENST00000405901.3_Missense_Mutation_p.R662T|SLC8A1_ENST00000406785.1_Intron			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	667					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CGGATGTTCTCTAGCATGAAC	0.423000													7	62					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121293249	121293249	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:121293249T>C	ENST00000297848.3	+	31	4045	c.3775T>C	c.(3775-3777)Ttt>Ctt	p.F1259L	COL14A1_ENST00000247781.3_Missense_Mutation_p.F1164L|COL14A1_ENST00000309791.4_Missense_Mutation_p.F1259L	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1259	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CTTCAATGTGTTTCCATGTTA	0.358000													7	98					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153078486	153078486	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:153078486C>T	ENST00000285900.5	+	10	1648	c.1305C>T	c.(1303-1305)taC>taT	p.Y435Y	GRIA1_ENST00000521843.2_Silent_p.Y366Y|GRIA1_ENST00000518783.1_Silent_p.Y445Y|GRIA1_ENST00000448073.4_Silent_p.Y445Y|GRIA1_ENST00000340592.5_Silent_p.Y435Y|GRIA1_ENST00000518142.1_Silent_p.Y355Y	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	435					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATGACCGTTACGAGGGCTACT	0.517000													18	78					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28586928	28586928	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:28586928A>G	ENST00000434452.1	-	12	1987	c.1833T>C	c.(1831-1833)agT>agC	p.S611S	DSC3_ENST00000360428.4_Silent_p.S611S	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	611	Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TATTGGGCAAACTGAAATAAA	0.343000													11	50					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112103073	112103073	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:112103073A>G	ENST00000457016.1	+	4	788	c.408A>G	c.(406-408)gaA>gaG	p.E136E	APC_ENST00000508376.2_Silent_p.E136E|APC_ENST00000257430.4_Silent_p.E136E			P25054	APC_HUMAN	adenomatous polyposis coli	136	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATTTAGAAGAACTTGAGAAAG	0.333000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			10	79					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31673101	31673101	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:31673101A>G	ENST00000340552.4	+	15	2266	c.2036A>G	c.(2035-2037)aAg>aGg	p.K679R	LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000333611.4_Intron|LIMK2_ENST00000406516.1_Missense_Mutation_p.K622R|LIMK2_ENST00000331728.4_Intron|LIMK2_ENST00000467301.1_Intron	NM_001031801.1	NP_001026971.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	0						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						GCCATGCAGAAGCTGAGCACA	0.597000													17	79					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8192624	8192624	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:8192624A>G	ENST00000162391.3	+	2	1341	c.196A>G	c.(196-198)Aag>Gag	p.K66E	FOXJ2_ENST00000428177.2_Missense_Mutation_p.K66E	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	66					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		CCAGGACGGCAAGCCACGATA	0.572000													7	141					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155569238	155569238	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:155569238C>T	ENST00000461783.3	+	22	5030	c.3757C>T	c.(3757-3759)Ctc>Ttc	p.L1253F	TIAM2_ENST00000456877.2_Missense_Mutation_p.L565F|TIAM2_ENST00000528391.2_Missense_Mutation_p.L589F|TIAM2_ENST00000318981.5_Missense_Mutation_p.L1253F|TIAM2_ENST00000275246.7_Missense_Mutation_p.L178F|TIAM2_ENST00000529824.2_Missense_Mutation_p.L1253F|TIAM2_ENST00000367174.2_Missense_Mutation_p.L629F|TIAM2_ENST00000360366.4_Missense_Mutation_p.L1277F|TIAM2_ENST00000456144.1_Missense_Mutation_p.L1253F			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1253	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TCAGAGAGTGCTCAAGTACCC	0.622000											OREG0017745	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	74					0	0	1	0	0
SNX2	6643	broad.mit.edu	37	5	122131076	122131076	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:122131076C>T	ENST00000379516.2	+	2	332	c.224C>T	c.(223-225)gCa>gTa	p.A75V	SNX2_ENST00000514949.1_5'UTR	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	75					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		GATCTTTTTGCAGGTAATTGT	0.323000													17	55					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72307674	72307674	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:72307674G>A	ENST00000334456.5	-	6	697	c.452C>T	c.(451-453)gCg>gTg	p.A151V	PDE2A_ENST00000540380.1_5'UTR|PDE2A_ENST00000444035.2_Missense_Mutation_p.A142V|PDE2A_ENST00000418754.2_Intron|PDE2A_ENST00000376450.3_Intron|PDE2A_ENST00000540345.1_Missense_Mutation_p.A142V|PDE2A_ENST00000544570.1_Missense_Mutation_p.A144V	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	151					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CTCCTTGTCCGCTAGCGGCAT	0.652000													18	49					0	0	1	0	0
HSDL1	83693	broad.mit.edu	37	16	84163962	84163962	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84163962G>A	ENST00000219439.4	-	4	471	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W	HSDL1_ENST00000434463.3_Missense_Mutation_p.R99W	NM_001146051.1|NM_031463.4	NP_001139523.1|NP_113651.4	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1	99						mitochondrion	oxidoreductase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7						TCCTCGTTCCGACTAATCAGG	0.463000													11	181					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284371	52284371	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52284371C>T	ENST00000301190.6	+	5	868	c.641C>T	c.(640-642)gCt>gTt	p.A214V	ANKRD33_ENST00000340970.4_Missense_Mutation_p.A89V|ANKRD33_ENST00000538991.1_Missense_Mutation_p.A20V|ANKRD33_ENST00000547119.1_3'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	89										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TTCCCAGGTGCTGACCTGACA	0.587000													10	26					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432362	107432362	+	Missense_Mutation	SNP	C	C	T	rs150004100		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:107432362C>T	ENST00000340010.5	-	4	479	c.295G>A	c.(295-297)Gac>Aac	p.D99N	SLC26A3_ENST00000422236.2_Missense_Mutation_p.D64N	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	99					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						GGGGGAATGTCGACCAGCAGA	0.448000													17	56					0	0	1	0	0
CKS2	1164	broad.mit.edu	37	9	91930190	91930190	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:91930190T>C	ENST00000314355.6	+	2	260	c.165T>C	c.(163-165)gtT>gtC	p.V55V		NM_001827.1	NP_001818.1	P33552	CKS2_HUMAN	CDC28 protein kinase regulatory subunit 2	55					cell division|cell proliferation|phosphatidylinositol-mediated signaling|regulation of cyclin-dependent protein kinase activity|spindle organization		cyclin-dependent protein kinase regulator activity			kidney(1)|large_intestine(1)	2						TAGGCTGGGTTCATTACATGA	0.373000													36	88					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62076603	62076603	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62076603A>G	ENST00000354587.3	-	3	678	c.502T>C	c.(502-504)Ttc>Ctc	p.F168L	KCNQ2_ENST00000357249.2_Missense_Mutation_p.F168L|KCNQ2_ENST00000344425.5_Missense_Mutation_p.F168L|KCNQ2_ENST00000370222.3_Missense_Mutation_p.F168L|KCNQ2_ENST00000370221.1_Missense_Mutation_p.F168L|KCNQ2_ENST00000359125.2_Missense_Mutation_p.F168L|KCNQ2_ENST00000370226.1_Missense_Mutation_p.F168L|KCNQ2_ENST00000360480.3_Missense_Mutation_p.F168L|KCNQ2_ENST00000359689.1_Missense_Mutation_p.F168L|KCNQ2_ENST00000344462.3_Missense_Mutation_p.F168L|KCNQ2_ENST00000430658.1_Missense_Mutation_p.F168L|KCNQ2_ENST00000370224.1_Missense_Mutation_p.F168L			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	168					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	ATCACACAGAACGGTTTCCGG	0.657000													22	67					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89157073	89157073	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:89157073T>C	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							GTTATCCACCTTCCACTGTAC	0.537000													17	45					0	0	1	0	0
KCMF1	56888	broad.mit.edu	37	2	85280508	85280508	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:85280508T>C	ENST00000409785.3	+	7	1481	c.1122T>C	c.(1120-1122)aaT>aaC	p.N374N		NM_020122.4	NP_064507.3	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	374						intracellular	ligase activity|zinc ion binding			ovary(3)	3						ATAAAGGAAATGAGCCTCCAC	0.418000													10	25					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39123307	39123307	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:39123307C>T	ENST00000216044.5	+	9	1724	c.1491C>T	c.(1489-1491)ctC>ctT	p.L497L		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	497					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					CCGAGATTCTCGTCCTCCACC	0.597000													4	115					0	0	1	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091487	11091487	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:11091487T>A	ENST00000537503.1	-	1	375	c.320A>T	c.(319-321)tAt>tTt	p.Y107F	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_023922.1	NP_076411.1	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	107					detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	8						CTTGAGAAAATAAAAAGTACC	0.373000													17	57					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15750672	15750672	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:15750672G>A	ENST00000285667.3	-	3	495	c.428C>T	c.(427-429)tCc>tTc	p.S143F	HSPA13_ENST00000544452.1_Intron|HSPA13_ENST00000478035.1_5'UTR	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	143						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						ATATTCTGGGGACACTGTGAT	0.373000													4	44					0	0	1	0	0
DBF4	10926	broad.mit.edu	37	7	87507395	87507395	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:87507395A>G	ENST00000265728.1	+	2	578	c.74A>G	c.(73-75)aAc>aGc	p.N25S		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	25					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				AATGAAAAAAACAGACCATCT	0.308000													47	162					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128482686	128482686	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:128482686T>C	ENST00000322313.4	-	9	1113	c.955A>G	c.(955-957)Aac>Gac	p.N319D		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	319					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCTTTTAGGTTTCTGATATCA	0.398000													20	41					0	0	1	0	0
RRAGC	64121	broad.mit.edu	37	1	39322675	39322675	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:39322675T>C	ENST00000373001.3	-	2	493	c.317A>G	c.(316-318)aAt>aGt	p.N106S		NM_022157.2	NP_071440.1	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	106					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)	10	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				AAAGGAGCTATTGGAAATGTC	0.403000													5	162					0	0	1	0	0
IER5L	389792	broad.mit.edu	37	9	131939288	131939288	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131939288C>A	ENST00000372491.2	-	1	1252	c.1044G>T	c.(1042-1044)ccG>ccT	p.P348P	RP11-247A12.2_ENST00000372490.3_RNA|RP11-247A12.8_ENST00000599172.2_RNA	NM_203434.2	NP_982258.2	Q5T953	IER5L_HUMAN	immediate early response 5-like	348													Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		TGGACGCGTCCGGGGACGAGT	0.716000													6	21					0.00116845	0.00118101	1	1	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900744	112900744	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:112900744T>C	ENST00000374530.3	+	8	3100	c.2920T>C	c.(2920-2922)Ttg>Ctg	p.L974L	AKAP2_ENST00000510514.5_Silent_p.L974L|PALM2-AKAP2_ENST00000302798.7_Silent_p.L974L|AKAP2_ENST00000555236.1_Silent_p.L974L|AKAP2_ENST00000259318.7_Silent_p.L743L|AKAP2_ENST00000482335.1_3'UTR|AKAP2_ENST00000374525.1_Silent_p.L832L|AKAP2_ENST00000434623.2_Silent_p.L832L	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		743							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						GAGACAAGTCTTGCAGAGTAC	0.532000													4	74					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132435	11132435	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11132435A>G	ENST00000358026.2	+	19	2935	c.2651A>G	c.(2650-2652)cAc>cGc	p.H884R	SMARCA4_ENST00000541122.2_Missense_Mutation_p.H884R|SMARCA4_ENST00000344626.4_Missense_Mutation_p.H884R|SMARCA4_ENST00000450717.3_Missense_Mutation_p.H884R|SMARCA4_ENST00000590574.1_Missense_Mutation_p.H884R|SMARCA4_ENST00000589677.1_Missense_Mutation_p.H884R|SMARCA4_ENST00000444061.3_Missense_Mutation_p.H884R|SMARCA4_ENST00000413806.3_Missense_Mutation_p.H884R|SMARCA4_ENST00000429416.3_Missense_Mutation_p.H884R	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	884	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.H884P(1)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GACGAAGGTCACCGCATGAAG	0.622000			"""F, N, Mis"""		NSCLC								8	33					0	0	1	0	0
LSG1	55341	broad.mit.edu	37	3	194380832	194380832	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:194380832T>C	ENST00000265245.5	-	6	866	c.552A>G	c.(550-552)cgA>cgG	p.R184R		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	184					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		GGAGTGGGTTTCGAGCATCTA	0.418000													4	86					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348596	220348596	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:220348596G>A	ENST00000312358.7	+	30	6543	c.6411G>A	c.(6409-6411)gaG>gaA	p.E2137E	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2137					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GTGAGGCGGAgccccggggcc	0.721000													13	23					0	0	1	0	0
USF1	7391	broad.mit.edu	37	1	161011565	161011565	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:161011565A>G	ENST00000368021.3	-	6	552	c.348T>C	c.(346-348)taT>taC	p.Y116Y	USF1_ENST00000435396.1_Silent_p.Y57Y|USF1_ENST00000368020.1_Silent_p.Y116Y|USF1_ENST00000368019.1_Silent_p.Y116Y	NM_007122.3	NP_009053.1	P22415	USF1_HUMAN	upstream transcription factor 1	116					cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGAAGTAAGTATAGTGCGTCT	0.577000											OREG0013936	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	105					0	0	1	0	0
SLC30A10	55532	broad.mit.edu	37	1	220088800	220088800	+	Silent	SNP	C	C	T	rs148203711		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:220088800C>T	ENST00000366926.3	-	4	1610	c.1449G>A	c.(1447-1449)acG>acA	p.T483T	SLC30A10_ENST00000536446.1_Silent_p.T238T|SLC30A10_ENST00000484079.1_5'UTR	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	483					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		ATTAAAAATGCGTTCTGTTGA	0.438000													59	218					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955510	18955510	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18955510G>A	ENST00000302797.3	-	1	1046	c.822C>T	c.(820-822)ttC>ttT	p.F274F		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	274					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGGAGCCCACGAAGAAGTAAA	0.512000													26	57					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882035	228882035	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:228882035T>C	ENST00000392056.3	-	7	3581	c.3535A>G	c.(3535-3537)Agc>Ggc	p.S1179G	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S1179G	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1179						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAGGGACAGCTAGGCCTCACA	0.532000													14	95					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323182	79323182	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:79323182C>A	ENST00000428286.1	-	8	4131	c.2931G>T	c.(2929-2931)agG>agT	p.R977S	PRUNE2_ENST00000376718.3_Missense_Mutation_p.R1336S			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1336					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CAAGGTGCCCCCTGTCAGTGG	0.527000													17	66					1.99824e-07	2.05285e-07	1	1	0
RNASE4	6038	broad.mit.edu	37	14	21167683	21167683	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21167683C>T	ENST00000555835.1	+	2	829	c.153C>T	c.(151-153)cgC>cgT	p.R51R	RNASE4_ENST00000555597.1_Silent_p.R51R|RNASE4_ENST00000304704.4_Silent_p.R51R|RP11-903H12.3_ENST00000554286.1_lincRNA|RNASE4_ENST00000397995.2_Silent_p.R51R|AL163636.6_ENST00000553909.1_RNA	NM_002937.3	NP_002928.1	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4	51					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		GCAGTGATCGCTACTGCAACT	0.527000													41	102					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2763675	2763675	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2763675T>C	ENST00000221566.2	-	6	634	c.473A>G	c.(472-474)tAc>tGc	p.Y158C		NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	158					interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCTTGCTGTAGGCCGGGTC	0.642000													11	23					0	0	1	0	0
SIRT4	23409	broad.mit.edu	37	12	120750395	120750395	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120750395G>C	ENST00000202967.4	+	3	693	c.634G>C	c.(634-636)Gtc>Ctc	p.V212L	SIRT4_ENST00000537892.1_3'UTR	NM_012240.2	NP_036372.1	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	212	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGAGGAGCAAGTCCGGAGCTT	0.557000													5	98					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14968915	14968915	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:14968915G>A	ENST00000287667.7	+	19	2248	c.2077G>A	c.(2077-2079)Gcc>Acc	p.A693T		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	693						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						CAGTGAACCCGCCTTGGTCTT	0.557000													45	90					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939549	12939549	+	Missense_Mutation	SNP	G	G	A	rs139720767		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:12939549G>A	ENST00000235349.5	-	4	1323	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	418										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCTCCCGGGGGGCAGGATA	0.517000													15	873					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27845798	27845798	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27845798G>A	ENST00000318304.8	+	29	3302	c.3019G>A	c.(3019-3021)Gaa>Aaa	p.E1007K	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.E976K|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.E1001K|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.E854K	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	1007					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					CATTACAGATGAAGACTCAAA	0.428000													16	67					0	0	1	0	0
NUDCD1	84955	broad.mit.edu	37	8	110305700	110305700	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:110305700T>C	ENST00000239690.4	-	4	887	c.513A>G	c.(511-513)tcA>tcG	p.S171S	NUDCD1_ENST00000427660.2_Silent_p.S142S	NM_032869.3	NP_116258.2	Q96RS6	NUDC1_HUMAN	NudC domain containing 1	171										breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(2)|skin(1)	25	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			CATTTAGCAGTGAGATACTGT	0.323000													24	105					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81229133	81229133	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:81229133A>G	ENST00000394685.3	+	24	3547	c.3128A>G	c.(3127-3129)tAc>tGc	p.Y1043C	RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000220244.3_Missense_Mutation_p.Y1043C|KIAA1199_ENST00000356249.5_Missense_Mutation_p.Y1043C			Q8WUJ3	K1199_HUMAN	KIAA1199	1043										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TACCAGCAATACCAACCGGTT	0.562000													46	101					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54310864	54310864	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54310864A>G	ENST00000324134.6	-	4	2296	c.2128T>C	c.(2128-2130)Tgc>Cgc	p.C710R	NLRP12_ENST00000354278.3_Missense_Mutation_p.C710R|NLRP12_ENST00000351894.4_Missense_Mutation_p.C710R|NLRP12_ENST00000345770.5_Missense_Mutation_p.C711R|NLRP12_ENST00000391772.1_Missense_Mutation_p.C711R|NLRP12_ENST00000391773.1_Missense_Mutation_p.C711R|NLRP12_ENST00000535162.1_Missense_Mutation_p.C710R|NLRP12_ENST00000391775.3_Missense_Mutation_p.C710R	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	710					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GGATTGGTGCACAGGGCCGCT	0.567000													25	71					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71060681	71060681	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:71060681T>A	ENST00000452400.2	-	12	2613	c.2432A>T	c.(2431-2433)gAt>gTt	p.D811V		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	811					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity	p.D811V(1)	PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CTGCAAATCATCCAAAATCTC	0.478000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""						OREG0018819	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	88					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1254932	1254932	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1254932G>A	ENST00000300952.2	+	6	1243	c.728G>A	c.(727-729)aGt>aAt	p.S243N	MIDN_ENST00000591446.2_Missense_Mutation_p.S243N	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	243						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCAGCAGTGCCAGTCCT	0.667000													36	133					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24580555	24580555	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:24580555A>G	ENST00000319715.4	+	17	2976	c.2544A>G	c.(2542-2544)ggA>ggG	p.G848G	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Silent_p.G814G	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	848					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		ATGCTGCTGGAGCACAGCCTA	0.418000													15	67					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127529492	127529492	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:127529492A>C	ENST00000284690.3	-	8	2107	c.1617T>G	c.(1615-1617)caT>caG	p.H539Q	BCCIP_ENST00000368759.5_Intron|BCCIP_ENST00000299130.3_Intron|DHX32_ENST00000368721.1_Missense_Mutation_p.H163Q|DHX32_ENST00000284688.6_Missense_Mutation_p.H458Q|BCCIP_ENST00000429863.2_Intron	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	539						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CTCCTTCGGGATGTAAAAATG	0.423000													4	145					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109526938	109526938	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:109526938T>C	ENST00000409271.1	-	9	1320	c.877A>G	c.(877-879)Act>Gct	p.T293A	EDAR_ENST00000376651.1_Missense_Mutation_p.T293A|EDAR_ENST00000258443.2_Missense_Mutation_p.T261A			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	261					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TTTGCTGGAGTTGCTGTCAGC	0.557000													7	33					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10079145	10079145	+	Silent	SNP	G	G	A	rs141650534		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10079145G>A	ENST00000264828.3	-	59	4315	c.4230C>T	c.(4228-4230)ctC>ctT	p.L1410L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1410	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent	p.L1410L(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGGGCCAATGAGACCGATCA	0.592000													66	158					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34004192	34004192	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:34004192C>G	ENST00000374181.3	-	8	1864	c.1695G>C	c.(1693-1695)cgG>cgC	p.R565R	GRM4_ENST00000535756.1_Silent_p.R432R|GRM4_ENST00000545715.1_Silent_p.R257R|GRM4_ENST00000455714.2_Silent_p.R425R|GRM4_ENST00000538487.1_Silent_p.R565R|GRM4_ENST00000544773.1_Silent_p.R396R|GRM4_ENST00000374177.3_Silent_p.R449R	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	565					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TCTCTGTGGGCCGCATGTCAT	0.647000													19	39					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1581142	1581142	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1581142T>C	ENST00000590550.2	-	4	831	c.458A>G	c.(457-459)aAc>aGc	p.N153S	MBD3_ENST00000592012.1_Missense_Mutation_p.N177S|MBD3_ENST00000434436.3_Missense_Mutation_p.N209S|MBD3_ENST00000156825.1_Missense_Mutation_p.N209S			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	209					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCGTGGTGTTGAGCCATAC	0.652000													5	68					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128862006	128862006	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:128862006G>A	ENST00000274487.4	+	4	1070	c.925G>A	c.(925-927)Gca>Aca	p.A309T	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	309					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TAGAAAAATAGCAGAAAGTGG	0.348000													13	46					0	0	1	0	0
SIX6	4990	broad.mit.edu	37	14	60976367	60976367	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:60976367A>G	ENST00000327720.5	+	1	699	c.251A>G	c.(250-252)cAc>cGc	p.H84R		NM_007374.2	NP_031400.2	O95475	SIX6_HUMAN	SIX homeobox 6	84					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)	11				OV - Ovarian serous cystadenocarcinoma(108;0.088)		AAGGAGTCGCACGCCAAGCTG	0.582000													5	55					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32585738	32585738	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:32585738A>G	ENST00000286827.3	-	11	2664	c.2193T>C	c.(2191-2193)ttT>ttC	p.F731F	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Intron	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	731					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CAATGTCATCAAATATTCCCT	0.388000													13	72					0	0	1	0	0
TMEM38A	79041	broad.mit.edu	37	19	16791318	16791318	+	Missense_Mutation	SNP	C	C	T	rs139650677		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16791318C>T	ENST00000187762.2	+	3	483	c.392C>T	c.(391-393)gCg>gTg	p.A131V		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	131						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity	p.A131V(1)		central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						CGCAAGATCGCGGTGGGCATC	0.527000													81	218					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238727040	238727040	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:238727040C>T	ENST00000316997.4	+	3	1613	c.1481C>T	c.(1480-1482)aCa>aTa	p.T494I	RBM44_ENST00000409864.1_Missense_Mutation_p.T494I|RBM44_ENST00000444524.2_Intron	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	493							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		GTAGTATCTACATCAAGCAAC	0.393000													14	61					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118698847	118698847	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:118698847A>G	ENST00000376300.2	-	19	1577	c.1440T>C	c.(1438-1440)atT>atC	p.I480I	CCDC93_ENST00000319432.5_Silent_p.I479I	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	480										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						TGCGGTGCAAAATTGCTATTT	0.428000													16	70					0	0	1	0	0
CLUH	23277	broad.mit.edu	37	17	2605231	2605231	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:2605231A>T	ENST00000570628.1	-	4	587	c.482T>A	c.(481-483)gTc>gAc	p.V161D	CLUH_ENST00000435359.1_Missense_Mutation_p.V161D|CLUH_ENST00000538975.1_Missense_Mutation_p.V161D|CLUH_ENST00000575014.1_Missense_Mutation_p.V93D					clustered mitochondria (cluA/CLU1) homolog																		GTCGGTGAAGACACTCAGGAA	0.672000													18	59					0	0	1	0	0
LMNB2	84823	broad.mit.edu	37	19	2438423	2438423	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2438423T>C	ENST00000325327.3	-	3	570	c.508A>G	c.(508-510)Aag>Gag	p.K170E	LMNB2_ENST00000582871.1_Missense_Mutation_p.K150E			Q03252	LMNB2_HUMAN	lamin B2	150	Coil 1B.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGCCGCGCTTGTCGCTGAGG	0.672000													16	27					0	0	1	0	0
GPCPD1	56261	broad.mit.edu	37	20	5528364	5528364	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:5528364A>G	ENST00000379019.4	-	20	2174	c.1962T>C	c.(1960-1962)tgT>tgC	p.C654C	GPCPD1_ENST00000481038.1_5'UTR	NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	654					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						CAGACTCCCCACACAAAGATG	0.483000													58	144					0	0	1	0	0
RTN4	57142	broad.mit.edu	37	2	55254564	55254564	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:55254564A>G	ENST00000337526.6	-	3	914	c.671T>C	c.(670-672)tTc>tCc	p.F224S	RTN4_ENST00000317610.7_Intron|RTN4_ENST00000357732.4_Intron|RTN4_ENST00000404909.1_Missense_Mutation_p.F18S|RTN4_ENST00000405240.1_Missense_Mutation_p.F18S|RTN4_ENST00000402434.2_Intron|RTN4_ENST00000394611.2_Missense_Mutation_p.F18S|RTN4_ENST00000357376.3_Missense_Mutation_p.F18S|RTN4_ENST00000354474.6_Intron	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	224					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						GACAGATGGGAAATCCTCTTG	0.443000													16	59					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	32914204	32914204	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:32914204T>C	ENST00000358763.2	-	13	1678	c.1436A>G	c.(1435-1437)cAa>cGa	p.Q479R	SYN3_ENST00000467095.1_5'UTR|SYN3_ENST00000332840.5_Missense_Mutation_p.Q479R	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	479	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TGGTGACCTTTGCTGCTGTGG	0.672000													51	141					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51503019	51503019	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:51503019A>G	ENST00000396402.1	-	10	1651	c.1498T>C	c.(1498-1500)Tgt>Cgt	p.C500R	CYP19A1_ENST00000396404.4_Missense_Mutation_p.C500R|CYP19A1_ENST00000559878.1_Missense_Mutation_p.C500R|CYP19A1_ENST00000260433.2_Missense_Mutation_p.C500R|RP11-108K3.1_ENST00000559909.1_lincRNA	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	500					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TGTTCCAGACACCTGTCTGAG	0.448000													35	160					0	0	1	0	0
BAG3	9531	broad.mit.edu	37	10	121436443	121436443	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:121436443C>T	ENST00000369085.3	+	4	1683	c.1377C>T	c.(1375-1377)acC>acT	p.T459T		NM_004281.3	NP_004272.2	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	459	BAG.				anti-apoptosis|apoptosis|protein folding	cytosol				endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(5)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	20		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AGTATTTGACCAAAGAGCTGC	0.532000													18	67					0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175436854	175436854	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:175436854C>T	ENST00000392547.2	-	5	778	c.679G>A	c.(679-681)Ggc>Agc	p.G227S	AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000409891.1_Missense_Mutation_p.G227S|WIPF1_ENST00000272746.5_Missense_Mutation_p.G227S|WIPF1_ENST00000409415.3_Missense_Mutation_p.G227S|WIPF1_ENST00000359761.3_Missense_Mutation_p.G227S|WIPF1_ENST00000392546.2_Missense_Mutation_p.G227S|AC018890.6_ENST00000412835.1_RNA	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	227					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						AAAGCAGTGCCGCGGTTTCCA	0.682000													20	55					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73564757	73564757	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:73564757G>A	ENST00000392550.3	+	11	1354	c.1237G>A	c.(1237-1239)Gca>Aca	p.A413T	LLGL2_ENST00000577200.1_Missense_Mutation_p.A413T|LLGL2_ENST00000167462.5_Missense_Mutation_p.A413T	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	413					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CCGGCAGAACGCACACTTCTC	0.612000													20	58					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076207	87076207	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:87076207T>A	ENST00000276616.2	-	2	913	c.839A>T	c.(838-840)aAt>aTt	p.N280I		NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	280	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			TCCTGTATAATTATATTTGCC	0.388000													9	51					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49245563	49245563	+	Missense_Mutation	SNP	C	C	T	rs140133186		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49245563C>T	ENST00000332955.2	-	7	1050	c.503G>A	c.(502-504)cGg>cAg	p.R168Q		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	168	Ig-like C2-type.				fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TTCCACATTCCGCTCTGGGGG	0.493000													26	75					0	0	1	0	0
FARP1	10160	broad.mit.edu	37	13	99047624	99047624	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:99047624T>C	ENST00000376586.2	+	13	1644	c.1308T>C	c.(1306-1308)ggT>ggC	p.G436G	FARP1_ENST00000319562.6_Silent_p.G436G|FARP1_ENST00000595437.1_Silent_p.G436G			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	436					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GCCCCGCGGGTAACAAGCAGG	0.692000													24	66					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103175892	103175892	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:103175892C>A	ENST00000424685.2	-	46	7379	c.7220G>T	c.(7219-7221)tGg>tTg	p.W2407L	RELN_ENST00000343529.5_Missense_Mutation_p.W2407L|RELN_ENST00000428762.1_Missense_Mutation_p.W2407L			P78509	RELN_HUMAN	reelin	2407					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAATGGGTGCCATGACAATCC	0.428000													16	66					6.94344e-10	7.18556e-10	1	1	0
OR52N5	390075	broad.mit.edu	37	11	5799574	5799574	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5799574A>G	ENST00000317093.2	-	1	323	c.291T>C	c.(289-291)agT>agC	p.S97S	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		TTTCTTTGAGACTGAACCAGA	0.473000													17	82					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11996053	11996053	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:11996053T>C	ENST00000333796.3	-	1	533	c.217A>G	c.(217-219)Agg>Ggg	p.R73G	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	73					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						GCAGGTCTCCTGCTACTCAGA	0.572000													13	78					0	0	1	0	0
PLEK2	26499	broad.mit.edu	37	14	67857432	67857432	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:67857432C>T	ENST00000216446.4	-	7	943	c.803G>A	c.(802-804)cGc>cAc	p.R268H		NM_016445.1	NP_057529.1	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	268	PH 2.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	15				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		TAGAACAAAGCGACGCACCTT	0.498000													25	136					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168366483	168366483	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:168366483G>A	ENST00000366806.2	+	32	5136	c.4994G>A	c.(4993-4995)cGc>cAc	p.R1665H	MLLT4_ENST00000351017.4_Missense_Mutation_p.R1672H|MLLT4_ENST00000392112.1_Missense_Mutation_p.R1648H|MLLT4_ENST00000400822.3_Missense_Mutation_p.R1675H|MLLT4_ENST00000447894.2_Missense_Mutation_p.R1665H			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1665					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GCCGAGAGGCGCAGACAGCAC	0.677000			T	MLL	AL								4	6					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49694495	49694495	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49694495G>C	ENST00000296452.4	+	5	7620	c.7506G>C	c.(7504-7506)tgG>tgC	p.W2502C		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2502					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCAGTATTGGCCCCCCCTTA	0.647000													27	68					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765562	47765562	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:47765562G>A	ENST00000273857.4	-	4	450	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	CORIN_ENST00000504584.1_Missense_Mutation_p.P151S|CORIN_ENST00000502252.1_Missense_Mutation_p.P84S|CORIN_ENST00000508498.1_Missense_Mutation_p.P12S|CORIN_ENST00000505909.1_Missense_Mutation_p.P151S	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	151	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GCGTGGTAGGGCAGCATCTGA	0.458000													19	94					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370980	240370980	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:240370980G>A	ENST00000319653.9	+	5	3098	c.2868G>A	c.(2866-2868)ccG>ccA	p.P956P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	956	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.P1099P(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TACCCCCTCCGCCCCCTCTTC	0.697000													9	66					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174235233	174235233	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:174235233A>T	ENST00000265000.4	+	9	1597	c.1514A>T	c.(1513-1515)cAc>cTc	p.H505L		NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	505					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		CGAGAAGATCACAACTGCAAA	0.403000													36	97					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71175157	71175157	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:71175157C>T	ENST00000319023.2	+	5	564	c.376C>T	c.(376-378)Ctg>Ttg	p.L126L		NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	126	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTACCGCGAGCTGCGCTGGTT	0.617000													4	10					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5655876	5655876	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5655876G>A	ENST00000354852.5	+	10	1770	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	TRIM34_ENST00000429814.2_Missense_Mutation_p.E179K|TRIM6-TRIM34_ENST00000457787.2_Missense_Mutation_p.E179K|HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000514226.1_Missense_Mutation_p.E179K	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		533						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		GGTACAAACTGAGAGACAAAG	0.413000													8	39					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713731	70713731	+	RNA	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:70713731A>C	ENST00000530196.1	-	0	787					NR_003951.1																						ATCATGGTTCACCACAACAAC	0.423000													29	92					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150784504	150784504	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:150784504G>A	ENST00000358595.5	-	22	2563	c.2363C>T	c.(2362-2364)tCa>tTa	p.S788L	ARNT_ENST00000505755.1_Missense_Mutation_p.S773L|ARNT_ENST00000515192.1_Missense_Mutation_p.S774L|ARNT_ENST00000354396.2_Missense_Mutation_p.S786L	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	788					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTTCTATTCTGAAAAGGGGGG	0.383000			T	ETV6	AML								23	42					0	0	1	0	0
FAM187B	148109	broad.mit.edu	37	19	35719090	35719090	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:35719090T>C	ENST00000324675.3	-	1	542	c.494A>G	c.(493-495)tAc>tGc	p.Y165C		NM_152481.1	NP_689694.1	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	165						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	9						AATGTAGCGGTACCCCAGGCG	0.612000													37	106					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12904439	12904439	+	Missense_Mutation	SNP	C	C	T	rs141848808		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:12904439C>T	ENST00000380659.3	+	3	951	c.812C>T	c.(811-813)gCg>gTg	p.A271V		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	271					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	TTTCCTTGTGCGCCGTGTAAA	0.378000													59	61					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151520221	151520221	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:151520221A>G	ENST00000535741.1	-	38	6457	c.5984T>C	c.(5983-5985)tTt>tCt	p.F1995S	LRBA_ENST00000357115.3_Missense_Mutation_p.F1995S|LRBA_ENST00000510413.1_Missense_Mutation_p.F1995S|LRBA_ENST00000507224.1_Missense_Mutation_p.F1995S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1995						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GTTACGCACAAATCGTCGCCG	0.488000													34	92					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47603695	47603695	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47603695A>G	ENST00000263774.4	+	5	519	c.437A>G	c.(436-438)tAc>tGc	p.Y146C	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	146					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	GTGAAGACCTACACAGATGAG	0.532000													55	138					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56015332	56015332	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:56015332C>T	ENST00000327381.5	+	1	384	c.284C>T	c.(283-285)gCg>gTg	p.A95V		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	95						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			gGCTCGGCTGCGCTGTGCCTG	0.781000													14	23					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58439140	58439140	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58439140A>G	ENST00000396147.1	-	4	700	c.409T>C	c.(409-411)Tat>Cat	p.Y137H	ZNF418_ENST00000425570.3_Missense_Mutation_p.Y158H|ZNF418_ENST00000599852.1_Missense_Mutation_p.Y52H|ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000595830.1_Missense_Mutation_p.Y137H	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CTGCTTCTATAGGGTTTCTCT	0.443000													20	211					0	0	1	0	0
THOC6	79228	broad.mit.edu	37	16	3077433	3077433	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3077433G>A	ENST00000326266.8	+	12	1173	c.877G>A	c.(877-879)Gtg>Atg	p.V293M	THOC6_ENST00000574549.1_Missense_Mutation_p.V269M|THOC6_ENST00000253952.9_Intron|THOC6_ENST00000575576.1_Missense_Mutation_p.V269M	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	293					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						GAAGGCCCAGGTGCCTGGCTC	0.701000													14	47					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4681107	4681107	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:4681107A>C	ENST00000302640.8	+	6	669	c.319A>C	c.(319-321)Aac>Cac	p.N107H	ITPR1_ENST00000456211.2_Missense_Mutation_p.N107H|ITPR1_ENST00000423119.2_Missense_Mutation_p.N107H|ITPR1_ENST00000544951.1_Missense_Mutation_p.N107H|ITPR1_ENST00000443694.2_Missense_Mutation_p.N107H|ITPR1_ENST00000354582.6_Missense_Mutation_p.N107H|ITPR1_ENST00000357086.4_Missense_Mutation_p.N107H	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	107					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TGAGACAGAAAACAGGAAATT	0.463000													7	11					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1808161	1808161	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:1808161A>G	ENST00000518288.1	+	5	527	c.364A>G	c.(364-366)Acg>Gcg	p.T122A	ARHGEF10_ENST00000398564.1_Missense_Mutation_p.T122A|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.T122A|ARHGEF10_ENST00000520359.1_Missense_Mutation_p.T98A|ARHGEF10_ENST00000398560.1_Missense_Mutation_p.T122A|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.T98A			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	122					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CATCGACATCACGCCATTCCA	0.602000													11	163					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478750	14478750	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:14478750C>T	ENST00000581457.1	-	0	1158					NR_024076.1																						GCCACTCATACTGTAATGGAA	0.348000													6	14					0	0	1	0	0
STRN3	29966	broad.mit.edu	37	14	31381256	31381256	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:31381256T>C	ENST00000355683.5	-	9	1470	c.1255A>G	c.(1255-1257)Acc>Gcc	p.T419A	STRN3_ENST00000357479.5_Missense_Mutation_p.T503A	NM_014574.3	NP_055389.3	Q13033	STRN3_HUMAN	striatin, calmodulin binding protein 3	435					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		AGTTTCAGGGTATGGTCCTCA	0.398000													6	166					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39836655	39836655	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:39836655T>C	ENST00000502986.2	+	4	546	c.304T>C	c.(304-306)Ttc>Ctc	p.F102L	RP11-44K6.3_ENST00000517623.1_RNA|IDO2_ENST00000343295.4_3'UTR|IDO2_ENST00000389060.4_Missense_Mutation_p.F89L	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	89					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						GGTCCTGAGCTTCCTCACCAT	0.617000													7	19					0	0	1	0	0
ZBTB18	10472	broad.mit.edu	37	1	244218341	244218341	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:244218341C>T	ENST00000358704.4	+	2	1414	c.1265C>T	c.(1264-1266)tCg>tTg	p.S422L		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		CCCACGTGCTCGCTGTGTGGG	0.637000													36	67					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402512	89402512	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:89402512G>A	ENST00000439576.2	+	12	7070	c.6696G>A	c.(6694-6696)acG>acA	p.T2232T	ACAN_ENST00000352105.7_Silent_p.T2232T|ACAN_ENST00000559004.1_Silent_p.T2232T|ACAN_ENST00000561243.1_Silent_p.T2232T	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2232					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGCAGAGACGCATCTAGAAA	0.577000													18	24					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37565066	37565066	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:37565066T>G	ENST00000264741.5	+	12	1547	c.1291T>G	c.(1291-1293)Tcg>Gcg	p.S431A	ITGA9_ENST00000422441.1_Missense_Mutation_p.S431A	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	431					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCAGTCCATATCGGGAGGCAT	0.398000													20	68					0	0	1	0	0
PLAC8L1	153770	broad.mit.edu	37	5	145464016	145464016	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:145464016C>T	ENST00000311450.4	-	4	570	c.513G>A	c.(511-513)atG>atA	p.M171I		NM_001029869.1	NP_001025040.1	A1L4L8	PL8L1_HUMAN	PLAC8-like 1	171										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|stomach(2)	10			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTCCTTAGTCATTGGGACTG	0.517000													19	159					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172482230	172482230	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:172482230C>A	ENST00000417960.1	+	12	1612	c.1135C>A	c.(1135-1137)Ctt>Att	p.L379I	ECT2_ENST00000232458.5_Missense_Mutation_p.L380I|ECT2_ENST00000540509.1_Missense_Mutation_p.L411I|ECT2_ENST00000441497.2_Missense_Mutation_p.L380I|ECT2_ENST00000427830.1_Missense_Mutation_p.L380I|ECT2_ENST00000392692.3_Missense_Mutation_p.L411I	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	380					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			TGAGCATTCCCTTTCCATAGG	0.433000													4	118					0.014758	0.0148535	1	1	0
CTSC	1075	broad.mit.edu	37	11	88033761	88033761	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:88033761G>T	ENST00000227266.5	-	5	808	c.694C>A	c.(694-696)Cca>Aca	p.P232T		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	232					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAAGATGTTGGCAAATGCAAA	0.343000													14	65					0.000219431	0.000222589	1	1	0
SIM1	6492	broad.mit.edu	37	6	100838718	100838718	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:100838718G>A	ENST00000369208.3	-	12	2602	c.1820C>T	c.(1819-1821)gCa>gTa	p.A607V	SIM1_ENST00000262901.4_Missense_Mutation_p.A607V			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	607	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TTGGTAGTTTGCAAAACACAG	0.478000													5	101					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3212165	3212165	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:3212165C>T	ENST00000380059.3	-	8	989	c.888G>A	c.(886-888)gcG>gcA	p.A296A	SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000380056.3_Silent_p.A269A|SLC4A11_ENST00000539553.1_Silent_p.A253A	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	269					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						CAAACGTGCGCGCCACCTCCA	0.602000													30	89					0	0	1	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212530583	212530583	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:212530583A>T	ENST00000261461.2	+	11	1757	c.1183A>T	c.(1183-1185)Atg>Ttg	p.M395L	PPP2R5A_ENST00000537030.3_Missense_Mutation_p.M338L	NM_006243.3	NP_006234.1	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B', alpha	395					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	16				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		TCTGCCAATTATGTTTGCCAG	0.284000													8	25					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16952724	16952724	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16952724T>C	ENST00000379803.1	+	4	541	c.527T>C	c.(526-528)tTc>tCc	p.F176S	SIN3B_ENST00000248054.5_Missense_Mutation_p.F176S|SIN3B_ENST00000596802.1_Missense_Mutation_p.F176S	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	176	PAH 2.				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						AAAACCCGCTTCCTAGACCAC	0.478000													4	118					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41135437	41135437	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41135437C>A	ENST00000308370.7	+	34	4854	c.4854C>A	c.(4852-4854)ccC>ccA	p.P1618P	LTBP4_ENST00000396819.3_Silent_p.P1551P|LTBP4_ENST00000204005.9_Silent_p.P1581P|LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000545697.1_3'UTR|LTBP4_ENST00000602240.1_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1619	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTGTGCGCCCGCACGGCCCC	0.736000													6	25					0.00198382	0.00200201	1	1	0
NTRK3	4916	broad.mit.edu	37	15	88678452	88678452	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:88678452A>T	ENST00000394480.1	-	10	1405	c.1084T>A	c.(1084-1086)Tgc>Agc	p.C362S	NTRK3_ENST00000357724.2_Missense_Mutation_p.C362S|NTRK3_ENST00000557856.1_Missense_Mutation_p.C362S|NTRK3_ENST00000542733.2_Missense_Mutation_p.C264S|NTRK3_ENST00000540489.2_Missense_Mutation_p.C362S|NTRK3_ENST00000360948.2_Missense_Mutation_p.C362S|NTRK3_ENST00000317501.3_Missense_Mutation_p.C362S|NTRK3_ENST00000558676.1_Missense_Mutation_p.C362S|NTRK3_ENST00000355254.2_Missense_Mutation_p.C362S	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	362	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAGAGCAGGCAGCCCTCGGAA	0.552000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			22	120					0	0	1	0	0
GOLGA5	9950	broad.mit.edu	37	14	93282745	93282745	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:93282745T>C	ENST00000163416.2	+	7	1726	c.1470T>C	c.(1468-1470)caT>caC	p.H490H	GOLGA5_ENST00000355976.2_Silent_p.H490H	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	490					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		GCCAGATACATCAGCTCAGAT	0.478000			T	RET	papillary thyroid								4	142					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63986797	63986797	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:63986797C>T	ENST00000279227.5	+	7	956	c.861C>T	c.(859-861)acC>acT	p.T287T	FERMT3_ENST00000345728.5_Silent_p.T287T	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	287	FERM.				integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						TTGACTGCACCGAGGAGGAGA	0.677000													6	21					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102748696	102748696	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:102748696C>A	ENST00000370228.1	+	1	914	c.729C>A	c.(727-729)gcC>gcA	p.A243A	C10orf2_ENST00000311916.2_Silent_p.A243A|C10orf2_ENST00000473656.1_Intron	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	243					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GACCCAGCGCCTACCACAATC	0.567000													27	76					4.87955e-14	5.09883e-14	1	1	0
TNR	7143	broad.mit.edu	37	1	175293598	175293598	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:175293598T>C	ENST00000367674.1	-	22	4559	c.3851A>G	c.(3850-3852)gAt>gGt	p.D1284G	TNR_ENST00000263525.2_Missense_Mutation_p.D1284G|RP3-518E13.2_ENST00000569593.1_RNA	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1284	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CACTGCAACATCATTGTCTCT	0.502000													32	87					0	0	1	0	0
SMAD3	4088	broad.mit.edu	37	15	67459160	67459160	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:67459160T>C	ENST00000327367.4	+	4	886	c.576T>C	c.(574-576)agT>agC	p.S192S	SMAD3_ENST00000537194.2_5'UTR|SMAD3_ENST00000439724.3_Silent_p.S148S|SMAD3_ENST00000540846.2_Silent_p.S87S	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	192	Linker.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GAGAAACCAGTGACCACCAGA	0.527000													3	6					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733136	56733136	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56733136G>C	ENST00000587340.1	-	7	1994	c.1299C>G	c.(1297-1299)agC>agG	p.S433R	ZSCAN5A_ENST00000391713.1_Missense_Mutation_p.S433R|ZSCAN5A_ENST00000254165.3_Missense_Mutation_p.S316R|ZSCAN5A_ENST00000592355.1_Missense_Mutation_p.S432R|ZSCAN5A_ENST00000587492.1_Missense_Mutation_p.S287R			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	433					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CCCCTGTGTGGCTTCTCTTGT	0.537000													4	54					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24833454	24833454	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:24833454A>G	ENST00000395799.3	+	23	5488	c.5359A>G	c.(5359-5361)Aac>Gac	p.N1787D	TNRC6A_ENST00000315183.7_Missense_Mutation_p.N1738D|TNRC6A_ENST00000432286.2_Missense_Mutation_p.N265D	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1787	RRM.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TGTTCTAAAAAACCTTACACC	0.473000													17	43					0	0	1	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166537	180166537	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:180166537A>G	ENST00000307832.2	-	1	562	c.522T>C	c.(520-522)aaT>aaC	p.N174N		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAAGAAGTGATTCAGTCGAT	0.552000													18	73					0	0	1	0	0
GXYLT2	727936	broad.mit.edu	37	3	73006420	73006420	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:73006420T>C	ENST00000389617.4	+	5	1054	c.893T>C	c.(892-894)tTg>tCg	p.L298S		NM_001080393.1	NP_001073862.1	A0PJZ3	GXLT2_HUMAN	glucoside xylosyltransferase 2	298					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	18						GAGGACATGTTGTACCCTCTG	0.413000													15	36					0	0	1	0	0
PDZD8	118987	broad.mit.edu	37	10	119042842	119042842	+	Silent	SNP	T	T	C	rs148191940		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:119042842T>C	ENST00000334464.5	-	5	3641	c.3402A>G	c.(3400-3402)ctA>ctG	p.L1134L		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1134					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		GAGAGTCTATTAGTTGGCTTA	0.383000													6	72					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675635	183675635	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:183675635G>A	ENST00000511685.1	+	22	4238	c.4115G>A	c.(4114-4116)cGt>cAt	p.R1372H	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.R1372H					teneurin transmembrane protein 3									p.R1372L(1)|p.R1372H(1)									ACTGAAAATCGTCAAGTTCGC	0.493000													5	18					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72827996	72827996	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:72827996G>T	ENST00000268489.5	-	9	9257	c.8585C>A	c.(8584-8586)gCa>gAa	p.A2862E	ZFHX3_ENST00000397992.5_Missense_Mutation_p.A1948E	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2862					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GGTTTCAGTTGCTATTCCCGT	0.498000													4	171					0.00909568	0.00915862	1	1	0
METTL25	84190	broad.mit.edu	37	12	82792639	82792639	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:82792639A>G	ENST00000248306.3	+	4	666	c.597A>G	c.(595-597)aaA>aaG	p.K199K	METTL25_ENST00000547357.1_3'UTR	NM_032230.2	NP_115606.2			methyltransferase like 25																		ATGGCTTAAAAGTTTATGGAA	0.338000													9	44					0	0	1	0	0
UTP15	84135	broad.mit.edu	37	5	72868354	72868354	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:72868354A>T	ENST00000296792.4	+	7	969	c.714A>T	c.(712-714)ggA>ggT	p.G238G	UTP15_ENST00000543251.1_Silent_p.G48G|UTP15_ENST00000508491.1_Silent_p.G219G	NM_032175.2	NP_115551.2	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)	238					rRNA processing	cytoplasm|nucleolus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	15		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		TAAAAGGAGGACAATTGCTAG	0.383000													55	177					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17835879	17835879	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17835879C>A	ENST00000324096.4	+	4	476	c.325C>A	c.(325-327)Cct>Act	p.P109T	MAP1S_ENST00000544059.2_Missense_Mutation_p.P83T|MAP1S_ENST00000597681.1_Intron	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	109	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						TCTGTTGGACCCTGCCTCTCA	0.607000													51	116					5.12918e-33	5.43649e-33	1	1	0
MYO5A	4644	broad.mit.edu	37	15	52609406	52609406	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:52609406G>A	ENST00000399231.3	-	39	5416	c.5173C>T	c.(5173-5175)Caa>Taa	p.Q1725*	MYO5A_ENST00000553916.1_Nonsense_Mutation_p.Q1723*|MYO5A_ENST00000356338.6_Nonsense_Mutation_p.Q1698*|MYO5A_ENST00000399233.2_Nonsense_Mutation_p.Q1722*|MYO5A_ENST00000358212.6_Nonsense_Mutation_p.Q1750*	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1725	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TCTTCCAGTTGACTGACATTG	0.388000													15	32					0	0	1	0	0
RANBP10	57610	broad.mit.edu	37	16	67761766	67761766	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67761766C>T	ENST00000317506.3	-	12	1623	c.1508G>A	c.(1507-1509)gGc>gAc	p.G503D	RANBP10_ENST00000411657.2_Missense_Mutation_p.G416D|RANBP10_ENST00000536251.1_Missense_Mutation_p.G274D|RANBP10_ENST00000602677.1_Missense_Mutation_p.G533D|RANBP10_ENST00000448631.2_Missense_Mutation_p.G477D	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	503										endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		AGCCTGGTTGCCCCCGCAGAG	0.597000													14	41					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72189934	72189934	+	Nonsense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:72189934G>C	ENST00000356056.5	-	25	5382	c.4910C>G	c.(4909-4911)tCa>tGa	p.S1637*	MYO9A_ENST00000424560.1_Nonsense_Mutation_p.S1637*|MYO9A_ENST00000444904.1_Nonsense_Mutation_p.S1618*|MYO9A_ENST00000566885.1_Nonsense_Mutation_p.S1257*|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000564571.1_Nonsense_Mutation_p.S1637*	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1637	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GCGATTATTTGAGAGTTTACA	0.418000													19	76					0	0	1	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310261	178310261	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:178310261T>C	ENST00000322434.3	+	5	1034	c.808T>C	c.(808-810)Tat>Cat	p.Y270H		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAGAAACCCTATATATGTAA	0.353000													35	98					0	0	1	0	0
ILVBL	10994	broad.mit.edu	37	19	15230010	15230010	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:15230010C>T	ENST00000263383.3	-	9	1157	c.1018G>A	c.(1018-1020)Gcc>Acc	p.A340T	ILVBL_ENST00000534378.1_Missense_Mutation_p.A233T	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	340						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						TTCTTCAGGGCCGCACTGCGG	0.632000													5	100					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43242348	43242348	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:43242348T>C	ENST00000422911.1	-	16	2079	c.1978A>G	c.(1978-1980)Aag>Gag	p.K660E	PRDM15_ENST00000538201.1_Missense_Mutation_p.K623E|PRDM15_ENST00000269844.3_Missense_Mutation_p.K969E|PRDM15_ENST00000447207.2_Missense_Mutation_p.K603E|PRDM15_ENST00000398548.1_Missense_Mutation_p.K640E			P57071	PRD15_HUMAN	PR domain containing 15	969					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						ATCCCGATCTTGCCGATAAAC	0.547000													5	122					0	0	1	0	0
RAB19	401409	broad.mit.edu	37	7	140110805	140110805	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:140110805T>C	ENST00000275874.5	+	3	432	c.234T>C	c.(232-234)agT>agC	p.S78S	RAB19_ENST00000537763.1_Intron|RAB19_ENST00000356407.3_Intron			A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	67					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(3)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	9	Melanoma(164;0.0142)					CCTTTGCCAGTATTCAGATCC	0.423000													6	314					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39331791	39331791	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:39331791G>A	ENST00000263408.4	-	5	697	c.602C>T	c.(601-603)tCt>tTt	p.S201F	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	201	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ATAGATCAAAGAAGCCACGTT	0.398000													35	80					0	0	1	0	0
USP43	124739	broad.mit.edu	37	17	9631694	9631694	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:9631694G>A	ENST00000570827.2	+	15	2900	c.1826G>A	c.(1825-1827)gGg>gAg	p.G609E	USP43_ENST00000285199.6_Missense_Mutation_p.G920E|USP43_ENST00000570475.1_Missense_Mutation_p.G915E			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	920					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						GAAAATGCAGGGCAGGACATC	0.572000													3	27					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103359222	103359222	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:103359222C>T	ENST00000520539.1	-	6	1091	c.485G>A	c.(484-486)cGg>cAg	p.R162Q	UBR5_ENST00000521922.1_Missense_Mutation_p.R162Q|UBR5_ENST00000220959.4_Missense_Mutation_p.R162Q	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	162					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCGTCCTGTCCGAATAACTCG	0.567000													67	208					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283110	152283110	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152283110G>A	ENST00000368799.1	-	3	4287	c.4252C>T	c.(4252-4254)Ccc>Tcc	p.P1418S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1418	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTGATGGGGCCCAGCTTGT	0.562000									Ichthyosis				10	475					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152417174	152417174	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:152417174T>C	ENST00000397345.3	-	124	19448	c.19246A>G	c.(19246-19248)Agc>Ggc	p.S6416G	NEB_ENST00000409198.1_Missense_Mutation_p.S4715G|NEB_ENST00000172853.10_Missense_Mutation_p.S4715G|NEB_ENST00000427231.2_Missense_Mutation_p.S6416G|NEB_ENST00000603639.1_Missense_Mutation_p.S6416G|NEB_ENST00000604864.1_Missense_Mutation_p.S6416G	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6415					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGGATGTAGCTGGTGGCTTTC	0.478000													8	16					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160176433	160176433	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:160176433T>C	ENST00000358372.4	+	8	2738	c.981T>C	c.(979-981)ggT>ggC	p.G327G	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	327					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GAGGTAGTGGTTACGTAAATC	0.493000													19	80					0	0	1	0	0
NDNL2	56160	broad.mit.edu	37	15	29561504	29561504	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:29561504A>G	ENST00000332303.4	-	1	529	c.406T>C	c.(406-408)Tac>Cac	p.Y136H	FAM189A1_ENST00000261275.4_Intron	NM_138704.3	NP_619649.1	Q96MG7	MAGG1_HUMAN	necdin-like 2	136	MAGE.				regulation of growth	cytoplasm|nucleus				breast(3)|large_intestine(2)|lung(3)	8		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CCGAAGACGTACTGGAGGCGC	0.567000													25	52					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138967993	138967993	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:138967993A>G	ENST00000288561.8	+	15	2342	c.2093A>G	c.(2092-2094)aAc>aGc	p.N698S	UBN2_ENST00000473989.2_Missense_Mutation_p.N781S	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	781										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						AACAATGGGAACAAGGGCCCT	0.463000													4	168					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108589383	108589383	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:108589383A>G	ENST00000263054.6	-	3	682	c.675T>C	c.(673-675)ggT>ggC	p.G225G	SORCS1_ENST00000344440.6_Silent_p.G225G	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	225						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGGTTTTCAAACCAACTTTAT	0.368000													27	63					0	0	1	0	0
FNIP2	57600	broad.mit.edu	37	4	159790348	159790348	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:159790348G>A	ENST00000264433.6	+	13	2635	c.2560G>A	c.(2560-2562)Gcc>Acc	p.A854T	FNIP2_ENST00000379346.3_Missense_Mutation_p.A877T	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	854	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		GGAGCCTGTTGCCCCCAGGTG	0.617000													4	123					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150923823	150923823	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:150923823T>C	ENST00000261800.5	-	9	6877	c.6865A>G	c.(6865-6867)Acc>Gcc	p.T2289A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2289	Cadherin 20.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCACAGGGGTCTGAGCAGGC	0.502000													10	128					0	0	1	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21936761	21936761	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:21936761C>T	ENST00000542643.2	-	15	1153	c.851G>A	c.(850-852)cGg>cAg	p.R284Q	RAP1GAP_ENST00000374761.2_Missense_Mutation_p.R315Q|RAP1GAP_ENST00000290101.4_Missense_Mutation_p.R348Q|RAP1GAP_ENST00000374763.2_Missense_Mutation_p.R284Q|RAP1GAP_ENST00000374765.4_Missense_Mutation_p.R284Q	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	284	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GTGCCGCTTCCGCTGCAACTG	0.617000													18	72					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89156999	89156999	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:89156999T>C	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							CTGCTGAGGCTGTAGGTGCTG	0.567000													4	64					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37319379	37319379	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:37319379T>C	ENST00000262825.5	+	3	387	c.170T>C	c.(169-171)gTc>gCc	p.V57A	CSF2RB_ENST00000403662.3_Missense_Mutation_p.V57A|CSF2RB_ENST00000406230.1_Missense_Mutation_p.V57A	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	57					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CAGCGGCTCGTCAACGTGACC	0.642000													15	41					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19221656	19221656	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19221656C>T	ENST00000318596.7	+	8	1079	c.928C>T	c.(928-930)Cag>Tag	p.Q310*		NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	310					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			CGACCTCATGCAGATCCTGCT	0.637000													21	81					0	0	1	0	0
ATL2	64225	broad.mit.edu	37	2	38570428	38570428	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:38570428A>G	ENST00000378954.4	-	2	346	c.345T>C	c.(343-345)ctT>ctC	p.L115L	ATL2_ENST00000452935.2_Silent_p.L97L|ATL2_ENST00000332337.4_Silent_p.L97L|ATL2_ENST00000546051.1_Intron|ATL2_ENST00000539122.1_Intron|ATL2_ENST00000406122.1_Intron|ATL2_ENST00000402054.1_Intron|ATL2_ENST00000419554.2_Silent_p.L115L	NM_001135673.1|NM_022374.2	NP_001129145.1|NP_071769.2	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2	115					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22						ACATGTATCTAAGCATGAAGT	0.348000													25	60					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63982054	63982054	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:63982054A>G	ENST00000398590.3	+	12	3109	c.2556A>G	c.(2554-2556)aaA>aaG	p.K852K	ATXN7_ENST00000295900.6_Silent_p.K852K|ATXN7_ENST00000487717.1_Silent_p.K852K|ATXN7_ENST00000484332.1_Silent_p.K707K|ATXN7_ENST00000538065.1_Silent_p.K852K	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	852					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		GCAGCAGCAAACCCACAAAGG	0.507000													10	81					0	0	1	0	0
NOL11	25926	broad.mit.edu	37	17	65735667	65735667	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:65735667G>A	ENST00000253247.4	+	16	1993	c.1878G>A	c.(1876-1878)aaG>aaA	p.K626K	NOL11_ENST00000535137.1_Silent_p.K444K	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	626						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTACCTGAAGTGTAGCGAAA	0.338000													16	46					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23116637	23116637	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:23116637T>C	ENST00000397677.1	+	9	1766	c.1118T>C	c.(1117-1119)tTa>tCa	p.L373S	CHMP7_ENST00000520102.1_3'UTR|CHMP7_ENST00000313219.7_Missense_Mutation_p.L373S	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	373					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		ACAAATGGCTTAGGTGAGTGG	0.448000													4	186					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74113333	74113333	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:74113333A>C	ENST00000324896.4	+	4	670	c.281A>C	c.(280-282)aAa>aCa	p.K94T	GTF2I_ENST00000443166.1_Missense_Mutation_p.K94T|AC083884.8_ENST00000450426.2_RNA|GTF2I_ENST00000346152.4_Missense_Mutation_p.K94T|GTF2I_ENST00000353920.4_Missense_Mutation_p.K94T|GTF2I_ENST00000416070.1_Missense_Mutation_p.K94T	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	94					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						CATAAAATGAAATCTACAACC	0.313000													3	8					0	0	1	0	0
DHH	50846	broad.mit.edu	37	12	49485061	49485061	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49485061A>G	ENST00000266991.2	-	2	721	c.415T>C	c.(415-417)Tca>Cca	p.S139P	RP11-386G11.8_ENST00000553174.1_RNA	NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	139					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						TAGTGGAGTGAATCCTGAGCG	0.622000													45	123					0	0	1	0	0
PXN	5829	broad.mit.edu	37	12	120652959	120652959	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120652959C>T	ENST00000397506.3	-	5	1540	c.487G>A	c.(487-489)Gcc>Acc	p.A163T	PXN_ENST00000424649.2_Missense_Mutation_p.A317T|PXN_ENST00000267257.7_Missense_Mutation_p.A365T|PXN_ENST00000458477.2_Missense_Mutation_p.A184T|PXN_ENST00000536957.1_Missense_Mutation_p.A349T|PXN_ENST00000228307.7_Missense_Mutation_p.A351T|PXN_ENST00000538144.1_5'UTR			P49023	PAXI_HUMAN	paxillin	351					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGACTGTGGCGACCCCCAGC	0.692000													13	21					0	0	1	0	0
SLC39A7	7922	broad.mit.edu	37	6	33170386	33170386	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:33170386A>G	ENST00000374677.3	+	5	1222	c.849A>G	c.(847-849)acA>acG	p.T283T	SLC39A7_ENST00000374675.3_Silent_p.T283T|SLC39A7_ENST00000463972.1_3'UTR	NM_006979.2	NP_008910.2	Q92504	S39A7_HUMAN	solute carrier family 39 (zinc transporter), member 7	283						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			NS(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						AAAAGGAAACAAGAGGGGTTC	0.498000													12	37					0	0	1	0	0
ASPHD2	57168	broad.mit.edu	37	22	26829974	26829974	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:26829974G>T	ENST00000215906.5	+	2	831	c.393G>T	c.(391-393)caG>caT	p.Q131H		NM_020437.4	NP_065170.2	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	131					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	16						ACAACCTGCAGGAGTACGCCA	0.642000													16	56					2.23348e-06	2.28775e-06	1	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27829385	27829385	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27829385C>T	ENST00000318304.8	+	18	1769	c.1486C>T	c.(1486-1488)Cca>Tca	p.P496S	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.P465S|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.P479S|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.P343S	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	496					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					AGAAAGCAGGCCATTTGGGAC	0.557000													64	86					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102332636	102332636	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:102332636G>A	ENST00000395065.3	-	18	1591	c.1490C>T	c.(1489-1491)aCc>aTc	p.T497I	NXF3_ENST00000497850.1_5'UTR|NXF3_ENST00000425644.1_Missense_Mutation_p.T169I	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	497						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TTGGTGGCTGGTATCCCGCAC	0.577000													54	56					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177046431	177046431	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:177046431A>T	ENST00000393643.2	+	5	967	c.715A>T	c.(715-717)Aat>Tat	p.N239Y	WDR17_ENST00000507824.2_Missense_Mutation_p.N246Y|WDR17_ENST00000280190.4_Missense_Mutation_p.N263Y|WDR17_ENST00000508596.1_Missense_Mutation_p.N239Y	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	263										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		AACAACATTTAATCTTCCCAG	0.438000													35	92					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32267263	32267263	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:32267263A>G	ENST00000360482.2	-	3	1555		c.e3+1		SPOCD1_ENST00000533231.1_Splice_Site|SPOCD1_ENST00000257100.3_Splice_Site|SPOCD1_ENST00000373648.2_Splice_Site	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1						transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GTAAAAACCTACGTAGCACAC	0.507000													30	97					0	0	1	0	0
GPD2	2820	broad.mit.edu	37	2	157406154	157406154	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:157406154T>C	ENST00000310454.6	+	7	1068	c.696T>C	c.(694-696)atT>atC	p.I232I	GPD2_ENST00000438166.2_Silent_p.I232I|GPD2_ENST00000540309.1_Silent_p.I232I|GPD2_ENST00000409674.1_Silent_p.I232I|GPD2_ENST00000409125.4_Silent_p.I5I	NM_001083112.2	NP_001076581.2	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	232					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|stomach(1)	22						ACCTTGCCATTGCTCTGACTG	0.552000													16	83					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992579	85992579	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:85992579A>G	ENST00000372105.3	-	4	997	c.976T>C	c.(976-978)Tac>Cac	p.Y326H		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	326	Ig-like C2-type.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						TGGCAGATGTAGTCTCCGGAG	0.567000													12	28					0	0	1	0	0
CCDC151	115948	broad.mit.edu	37	19	11545754	11545754	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11545754C>G	ENST00000356392.4	-	1	171	c.84G>C	c.(82-84)aaG>aaC	p.K28N	CCDC151_ENST00000586836.1_Intron|CCDC151_ENST00000545100.1_Intron|CCDC151_ENST00000591179.1_Missense_Mutation_p.K28N	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	28										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						CCTCCCTGCCCTTGACCCTGG	0.667000											OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	97					0	0	1	0	0
MC5R	4161	broad.mit.edu	37	18	13826297	13826297	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:13826297T>C	ENST00000324750.3	+	1	755	c.533T>C	c.(532-534)aTc>aCc	p.I178T		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	178					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						ATTGTCTTCATCCTGTACTCA	0.562000													165	606					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109804950	109804950	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109804950G>A	ENST00000271332.3	+	6	4489	c.4428G>A	c.(4426-4428)gaG>gaA	p.E1476E		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1476	Laminin G-like 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCCCATCAGAGCAGAAGGTGG	0.607000													17	38					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49432223	49432223	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49432223C>T	ENST00000301067.7	-	34	8915	c.8916G>A	c.(8914-8916)gaG>gaA	p.E2972E		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGCGGCCAAGCTCAGTGCTCG	0.592000													35	122					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41596072	41596072	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41596072T>C	ENST00000330436.3	+	3	464	c.464T>C	c.(463-465)tTc>tCc	p.F155S		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	155					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	GAGGCGGGCTTCCTCATCGAC	0.692000													19	47					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33044429	33044429	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:33044429G>A	ENST00000286835.7	-	20	3109	c.2727C>T	c.(2725-2727)ttC>ttT	p.F909F	SCAF4_ENST00000434667.3_Silent_p.F894F|SCAF4_ENST00000399804.1_Silent_p.F887F	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	909						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CATGCGGTGGGAAGGGACCTT	0.662000													31	72					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121868266	121868266	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:121868266T>C	ENST00000377069.4	-	22	4035	c.3629A>G	c.(3628-3630)aAt>aGt	p.N1210S	KDM2B_ENST00000536437.1_Missense_Mutation_p.I539V|RNF34_ENST00000392464.2_Missense_Mutation_p.I498T|KDM2B_ENST00000377071.4_Missense_Mutation_p.N1279S|KDM2B_ENST00000542973.1_Missense_Mutation_p.N647S	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1279					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						AGTGACCTTATTGCAGTCTGC	0.537000													4	196					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3234934	3234934	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:3234934G>A	ENST00000355072.5	+	61	8455	c.8310G>A	c.(8308-8310)acG>acA	p.T2770T	HTT_ENST00000513806.1_Intron	NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2770					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TGGAGAGCACGCTCAGGAGCA	0.647000													54	140					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40061860	40061860	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:40061860C>T	ENST00000352035.2	-	9	1048	c.918G>A	c.(916-918)gaG>gaA	p.E306E	ACLY_ENST00000537919.1_Intron|ACLY_ENST00000590151.1_Silent_p.E306E|ACLY_ENST00000393896.2_Silent_p.E306E|ACLY_ENST00000353196.1_Silent_p.E306E	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	306					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CGCCTGAGTACTCCCCATAGT	0.557000													6	138					0	0	1	0	0
CCDC78	124093	broad.mit.edu	37	16	774145	774145	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:774145G>T	ENST00000293889.6	-	10	1119	c.1014C>A	c.(1012-1014)ccC>ccA	p.P338P		NM_001031737.2	NP_001026907.2	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	338										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(2)|skin(3)	9		Hepatocellular(780;0.0218)				CCAGGGGCACGGGCAATGGTT	0.637000													21	86					1.55795e-14	1.62985e-14	1	1	0
ATP2A1	487	broad.mit.edu	37	16	28914656	28914656	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:28914656C>T	ENST00000395503.4	+	21	3059	c.2875C>T	c.(2875-2877)Ctc>Ttc	p.L959F	ATP2A1_ENST00000536376.1_Missense_Mutation_p.L834F|ATP2A1_ENST00000357084.3_Missense_Mutation_p.L959F	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	959					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GATCTTCAAGCTCCGGGCCCT	0.622000													5	137					0	0	1	0	0
DVL1	1855	broad.mit.edu	37	1	1274021	1274021	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1274021G>A	ENST00000378888.5	-	12	1504	c.1220C>T	c.(1219-1221)gCg>gTg	p.A407V	DVL1_ENST00000378891.5_Missense_Mutation_p.A382V			O14640	DVL1_HUMAN	dishevelled segment polarity protein 1	407					canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGTCAGCGGCGCCTCTTCCAG	0.662000													14	30					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11227551	11227551	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11227551C>T	ENST00000558518.1	+	12	1909	c.1722C>T	c.(1720-1722)cgC>cgT	p.R574R	LDLR_ENST00000535915.1_Silent_p.R533R|LDLR_ENST00000558013.1_Silent_p.R574R|LDLR_ENST00000545707.1_Silent_p.R447R|LDLR_ENST00000455727.2_Silent_p.R406R|LDLR_ENST00000557933.1_Silent_p.R574R	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	574					cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	TCAGTGGCCGCCTCTACTGGG	0.587000													5	277					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207648545	207648545	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:207648545A>G	ENST00000367057.3	+	14	2889	c.2700A>G	c.(2698-2700)ccA>ccG	p.P900P	CR2_ENST00000367058.3_Silent_p.P841P|CR2_ENST00000367059.3_Silent_p.P841P|CR2_ENST00000458541.2_Silent_p.P814P	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	966	Sushi 14.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						CAGGTGTGCCAACTTGTATCA	0.403000													29	92					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44983791	44983791	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44983791G>A	ENST00000372227.1	-	6	1038	c.498C>T	c.(496-498)ttC>ttT	p.F166F	SLC35C2_ENST00000543605.1_Silent_p.F195F|SLC35C2_ENST00000372230.5_Silent_p.F166F|SLC35C2_ENST00000317734.8_Silent_p.F145F|SLC35C2_ENST00000372229.1_Silent_p.F33F|SLC35C2_ENST00000243896.2_Silent_p.F166F			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	166					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				GCACCAAGGCGAAGCCCTCCA	0.617000													34	65					0	0	1	0	0
DBNDD2	55861	broad.mit.edu	37	20	44037154	44037154	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:44037154T>C	ENST00000372712.2	+	2	628	c.47T>C	c.(46-48)cTt>cCt	p.L16P	DBNDD2_ENST00000372720.3_Missense_Mutation_p.L114P|DBNDD2_ENST00000372717.1_Missense_Mutation_p.L16P|SYS1-DBNDD2_ENST00000452133.1_3'UTR|DBNDD2_ENST00000372710.3_Missense_Mutation_p.L118P|DBNDD2_ENST00000360981.4_Missense_Mutation_p.L16P|SYS1-DBNDD2_ENST00000475242.1_3'UTR|DBNDD2_ENST00000372722.3_Missense_Mutation_p.L16P|DBNDD2_ENST00000357275.2_Missense_Mutation_p.L16P|DBNDD2_ENST00000372723.3_Missense_Mutation_p.L16P			Q9BQY9	DBND2_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 2	114					negative regulation of protein kinase activity	cytoplasm	protein binding			breast(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				CAGCTCCGCCTTCGGGAGCGG	0.552000													34	98					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112182670	112182670	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112182670T>A	ENST00000455480.2	+	14	2208	c.2031T>A	c.(2029-2031)caT>caA	p.H677Q	ACAD10_ENST00000313698.4_Missense_Mutation_p.H646Q|ACAD10_ENST00000549590.1_Missense_Mutation_p.H646Q|ACAD10_ENST00000392636.2_Missense_Mutation_p.H248Q|ACAD10_ENST00000413681.3_3'UTR	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	646							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CCCCAGCTCATACCTCAAGGG	0.577000													29	87					0	0	1	0	0
PHF20L1	51105	broad.mit.edu	37	8	133848928	133848928	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:133848928A>G	ENST00000395386.2	+	16	2352	c.2053A>G	c.(2053-2055)Att>Gtt	p.I685V	PHF20L1_ENST00000395390.2_Missense_Mutation_p.I660V|PHF20L1_ENST00000220847.7_Missense_Mutation_p.I72V	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	685							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGTGCGATGTATTTGTGAGAT	0.398000													4	144					0	0	1	0	0
POLR2I	5438	broad.mit.edu	37	19	36604715	36604715	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:36604715G>C	ENST00000221859.4	-	6	809	c.320C>G	c.(319-321)gCc>gGc	p.A107G		NM_006233.4	NP_006224.1	P36954	RPB9_HUMAN	polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	107					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)	3	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AAGGCGCATGGCGTCCTGGCA	0.557000											OREG0025437	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	39					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098499	78098499	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:78098499T>C	ENST00000370801.3	-	5	1016	c.541A>G	c.(541-543)Aat>Gat	p.N181D	ZZZ3_ENST00000370798.1_Intron|ZZZ3_ENST00000476275.1_5'UTR	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						TCACTGACATTCACCTTTTTA	0.398000													19	195					0	0	1	0	0
OR2K2	26248	broad.mit.edu	37	9	114089977	114089977	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:114089977A>G	ENST00000374428.1	-	1	823	c.824T>C	c.(823-825)gTg>gCg	p.V275A	OR2K2_ENST00000302681.1_Missense_Mutation_p.V246A			Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K, member 2	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)	20						CAAAATCACCACAGTCAAATG	0.418000													20	58					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	78119086	78119086	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:78119086T>C	ENST00000354212.4	-	6	1290	c.1037A>G	c.(1036-1038)aAa>aGa	p.K346R	MAGI2_ENST00000522391.1_Missense_Mutation_p.K346R|MAGI2_ENST00000535697.1_Missense_Mutation_p.K183R|MAGI2_ENST00000419488.1_Missense_Mutation_p.K346R|MAGI2_ENST00000536571.1_Missense_Mutation_p.K178R	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	346	Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ACCATTTTCTTTGCACTCTTC	0.388000													6	203					0	0	1	0	0
TIMMDC1	51300	broad.mit.edu	37	3	119217736	119217736	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:119217736A>G	ENST00000494664.1	+	1	358	c.156A>G	c.(154-156)gaA>gaG	p.E52E	TIMMDC1_ENST00000493694.1_Silent_p.E52E	NM_016589.3	NP_057673.2	Q9NPL8	TIDC1_HUMAN	translocase of inner mitochondrial membrane domain containing 1	52						integral to membrane|mitochondrial inner membrane	protein transporter activity			autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	15						ATTACCCGGAATCTGGATGGG	0.602000													40	113					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145838593	145838593	+	Silent	SNP	G	G	A	rs140816235	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:145838593G>A	ENST00000296702.5	+	4	623	c.585G>A	c.(583-585)gcG>gcA	p.A195A	TCERG1_ENST00000394421.2_Silent_p.A195A	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	195	Ala/Gln-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity	p.A195A(1)		breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			aggcccaggcgcaggctcagg	0.667000													16	57					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40557143	40557143	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:40557143G>A	ENST00000455577.2	+	4	1069	c.157G>A	c.(157-159)Gtg>Atg	p.V53M	PAK6_ENST00000542403.2_Missense_Mutation_p.V53M|PAK6_ENST00000260404.4_Missense_Mutation_p.V53M|RP11-133K1.2_ENST00000558658.1_Silent_p.P146P|PAK6_ENST00000560346.1_Missense_Mutation_p.V53M|PAK6_ENST00000453867.1_Missense_Mutation_p.V53M|PAK6_ENST00000441369.1_Missense_Mutation_p.V53M	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	53	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CCCCAAGCCCGTGGTGGACCC	0.622000													25	82					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1327714	1327714	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:1327714A>G	ENST00000381567.3	-	2	166	c.167T>C	c.(166-168)cTg>cCg	p.L56P	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Missense_Mutation_p.L56P	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	56						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GTGGAAAGTCAGGTTGGTCCT	0.507000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								6	139					0	0	1	0	0
FAM122A	116224	broad.mit.edu	37	9	71395719	71395719	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:71395719G>A	ENST00000394264.3	+	1	756	c.639G>A	c.(637-639)caG>caA	p.Q213Q	PIP5K1B_ENST00000541509.1_Intron|PIP5K1B_ENST00000265382.3_Intron	NM_138333.3	NP_612206.3	Q96E09	F122A_HUMAN	family with sequence similarity 122A	213										endometrium(1)|lung(2)	3						CTGAATATCAGCCAAAGAGAT	0.453000													21	107					0	0	1	0	0
POU3F3	5455	broad.mit.edu	37	2	105473289	105473289	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:105473289G>A	ENST00000361360.2	+	1	1321	c.1321G>A	c.(1321-1323)Gac>Aac	p.D441N	RP11-13J10.1_ENST00000598623.1_RNA	NM_006236.1	NP_006227.1	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	441					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12						CAACCTGGCCGACAGCCTGCA	0.642000													12	48					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20153137	20153137	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:20153137T>C	ENST00000263754.4	+	6	1356	c.901T>C	c.(901-903)Tac>Cac	p.Y301H		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	301					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						TCTACCTCGGTACGAAACCAC	0.488000													18	57					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37144935	37144935	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:37144935T>C	ENST00000262879.6	+	7	1257	c.973T>C	c.(973-975)Tat>Cat	p.Y325H	RALGAPB_ENST00000397042.3_Missense_Mutation_p.Y325H|RALGAPB_ENST00000397038.1_Missense_Mutation_p.Y103H|RALGAPB_ENST00000537204.1_Missense_Mutation_p.Y325H|RALGAPB_ENST00000397040.1_Missense_Mutation_p.Y325H			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	325					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						ATTGAATCAGTATCCCTGCCT	0.413000													47	154					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151849901	151849901	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:151849901G>A	ENST00000355193.2	-	50	12804	c.12586C>T	c.(12586-12588)Cga>Tga	p.R4196*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.R4139*					lysine (K)-specific methyltransferase 2C																		AAATGCTGTCGATACTCCAAA	0.527000													47	109					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65624371	65624371	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:65624371T>C	ENST00000327987.4	-	7	1307	c.1056A>G	c.(1054-1056)caA>caG	p.Q352Q	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	352	Ig-like C2-type 4.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CACCCTGGGCTTGGCAGGTGA	0.602000													24	43					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53153915	53153915	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:53153915A>G	ENST00000296292.3	-	6	742	c.681T>C	c.(679-681)aaT>aaC	p.N227N	RFT1_ENST00000394738.3_Silent_p.N188N	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	227					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		TTCTTGTAATATTGGGTAACA	0.348000													5	127					0	0	1	0	0
ADRA2B	151	broad.mit.edu	37	2	96781717	96781717	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:96781717C>T	ENST00000409345.3	-	1	267	c.172G>A	c.(172-174)Gac>Aac	p.D58N		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	58					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	ACCAGGATGTCGGCGGCGGCC	0.642000													3	41					0	0	1	0	0
SNIP1	79753	broad.mit.edu	37	1	38019681	38019681	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:38019681A>G	ENST00000296215.6	-	1	222	c.150T>C	c.(148-150)ggT>ggC	p.G50G	SNIP1_ENST00000468040.1_Intron	NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	50					production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				ACGGGCTACCACCGGAGTGGT	0.731000													9	17					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129303359	129303359	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:129303359A>G	ENST00000393239.1	-	6	2076	c.1898T>C	c.(1897-1899)aTg>aCg	p.M633T	PLXND1_ENST00000324093.4_Missense_Mutation_p.M633T			Q9Y4D7	PLXD1_HUMAN	plexin D1	633					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GGCCATCTCCATGCCACTGAG	0.632000													5	127					0	0	1	0	0
ZNF213	7760	broad.mit.edu	37	16	3189024	3189024	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3189024T>C	ENST00000396878.3	+	5	1121	c.646T>C	c.(646-648)Tgg>Cgg	p.W216R	ZNF213_ENST00000416391.2_Missense_Mutation_p.W58R|ZNF213_ENST00000574902.1_Missense_Mutation_p.W216R|ZNF213_ENST00000576416.1_Missense_Mutation_p.W216R	NM_001134655.1|NM_004220.2	NP_001128127.1|NP_004211.1	O14771	ZN213_HUMAN	zinc finger protein 213	216	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	16						CCGGGAAGAATGGGGCACCCT	0.622000													25	132					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13423545	13423545	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:13423545T>C	ENST00000360228.5	-	12	1605	c.1606A>G	c.(1606-1608)Aaa>Gaa	p.K536E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.K537E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	537					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCGTACATTTTTATAAACATT	0.443000													21	70					0	0	1	0	0
C16orf3	750	broad.mit.edu	37	16	90095731	90095731	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:90095731G>A	ENST00000408886.2	-	1	578	c.20C>T	c.(19-21)gCg>gTg	p.A7V	GAS8_ENST00000268699.4_Intron|GAS8_ENST00000540721.1_Intron|GAS8_ENST00000536122.1_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	7										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		ctcctgccccgcagcagagga	0.557000													30	79					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087638	47087638	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:47087638C>T	ENST00000374312.1	+	3	1274	c.855C>T	c.(853-855)aaC>aaT	p.N285N	NPY4R_ENST00000395716.1_Silent_p.N285N	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		ATGTGTTCAACAGCCTGGAAG	0.582000													15	67					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204412676	204412676	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:204412676A>G	ENST00000367187.3	-	20	3473	c.2917T>C	c.(2917-2919)Tat>Cat	p.Y973H	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.Y945H	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	973					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GCCAGCAGATACTGGTAGCGG	0.572000													55	198					0	0	1	0	0
LSM10	84967	broad.mit.edu	37	1	36859552	36859552	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:36859552G>A	ENST00000315732.2	-	2	328	c.179C>T	c.(178-180)aCg>aTg	p.T60M	LSM10_ENST00000476041.1_5'UTR	NM_032881.1	NP_116270.1	Q969L4	LSM10_HUMAN	LSM10, U7 small nuclear RNA associated	60					histone mRNA metabolic process|mRNA processing|RNA splicing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	Cajal body|U7 snRNP	histone pre-mRNA DCP binding|protein binding			upper_aerodigestive_tract(1)|urinary_tract(1)	2		Myeloproliferative disorder(586;0.0393)				CCAACGGTCCGTGTAGGTGAC	0.577000													21	85					0	0	1	0	0
ASB2	51676	broad.mit.edu	37	14	94404137	94404137	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:94404137G>T	ENST00000555019.1	-	9	2108	c.1678C>A	c.(1678-1680)Ctc>Atc	p.L560I	ASB2_ENST00000315988.4_Missense_Mutation_p.L512I	NM_001202429.1	NP_001189358.1	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box containing 2	512	SOCS box.				intracellular signal transduction					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(1)	27		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		TAGTCCAGGAGGACATCGATG	0.582000													7	67					8.12818e-05	8.26188e-05	1	1	0
POM121	9883	broad.mit.edu	37	7	72413274	72413274	+	Silent	SNP	C	C	T	rs148530018	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:72413274C>T	ENST00000395270.1	+	14	2988	c.1947C>T	c.(1945-1947)agC>agT	p.S649S	POM121_ENST00000358357.3_Silent_p.S649S|POM121_ENST00000434423.2_Silent_p.S914S|POM121_ENST00000446813.1_Silent_p.S649S|POM121_ENST00000257622.4_Silent_p.S649S	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	914	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CCAGCAGCAGCGCTGCCGACT	0.627000													49	151					0	0	1	0	0
TMEM66	51669	broad.mit.edu	37	8	29931572	29931572	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:29931572C>T	ENST00000256255.6	-	2	361		c.e2-1		TMEM66_ENST00000536273.1_Intron|TMEM66_ENST00000545648.1_Splice_Site|TMEM66_ENST00000521083.1_Splice_Site	NM_016127.4	NP_057211.4	Q96BY9	TMM66_HUMAN	transmembrane protein 66							integral to membrane				endometrium(2)|large_intestine(1)|lung(11)	14				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		AACATTCTGTCTGAAACAGCA	0.463000													9	120					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48314867	48314867	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48314867T>C	ENST00000435803.1	+	17	5628	c.5604T>C	c.(5602-5604)ggT>ggC	p.G1868G		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1868					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CTCCCCAAGGTGAAGATTCAC	0.418000													15	50					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46719881	46719881	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:46719881T>C	ENST00000318962.4	-	16	1710		c.e16-2		ALS2CL_ENST00000415953.1_Splice_Site	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like						endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GACCTTGCCCTGGGAGCCAGG	0.612000													23	50					0	0	1	0	0
FAM20B	9917	broad.mit.edu	37	1	179033563	179033563	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:179033563C>G	ENST00000263733.4	+	6	1206	c.870C>G	c.(868-870)cgC>cgG	p.R290R		NM_014864.3	NP_055679.1	O75063	XYLK_HUMAN	family with sequence similarity 20, member B	290						Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)	14						ATGCTGACCGCCATCACTATG	0.493000													20	66					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13698938	13698938	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:13698938C>T	ENST00000357447.2	-	22	3019	c.2651G>A	c.(2650-2652)cGc>cAc	p.R884H	FRMD4A_ENST00000378503.1_Missense_Mutation_p.R884H|FRMD4A_ENST00000358621.4_Missense_Mutation_p.R869H	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	884						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GCCGCCGCCGCGCCAGCTCTC	0.711000													4	18					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10280057	10280057	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:10280057G>T	ENST00000254976.2	+	7	760	c.549G>T	c.(547-549)gaG>gaT	p.E183D	SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000304886.2_Missense_Mutation_p.E183D|SNAP25_ENST00000495883.1_3'UTR	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	183	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	GGATCATGGAGAAGGTGAGCA	0.522000													5	53					0.000602214	0.000609374	1	1	0
CBLN4	140689	broad.mit.edu	37	20	54579152	54579152	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:54579152A>G	ENST00000064571.2	-	1	1376	c.76T>C	c.(76-78)Tgg>Cgg	p.W26R		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	26						cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			TTCTGTGCCCAGACGGGCAGC	0.721000													3	21					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20134903	20134903	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:20134903G>A	ENST00000379651.3	-	1	113	c.95C>T	c.(94-96)gCg>gTg	p.A32V	MAP7D2_ENST00000379643.5_Missense_Mutation_p.A32V|MAP7D2_ENST00000443379.3_Missense_Mutation_p.A32V	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	32			A -> P (in a breast cancer sample; somatic mutation).							NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						GGTCCGCACCGCGCCCGGTTC	0.726000													5	8					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61898753	61898753	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:61898753T>C	ENST00000280772.1	-	24	2898	c.2707A>G	c.(2707-2709)Atg>Gtg	p.M903V	ANK3_ENST00000373827.2_Missense_Mutation_p.M897V|ANK3_ENST00000460468.1_Missense_Mutation_p.M67V|ANK3_ENST00000503366.1_Missense_Mutation_p.M904V|ANK3_ENST00000355288.2_Missense_Mutation_p.M37V	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	903					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTAAAGCCCATGTAACCCTCT	0.448000													29	110					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179306696	179306696	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:179306696T>C	ENST00000356834.3	-	8	1385	c.1348A>G	c.(1348-1350)Acc>Gcc	p.T450A	TBC1D9B_ENST00000355235.3_Missense_Mutation_p.T450A	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	450						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGGATGCGGTTGGCGCCTCC	0.667000													34	106					0	0	1	0	0
SMCR8	140775	broad.mit.edu	37	17	18220641	18220641	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:18220641G>A	ENST00000406438.3	+	1	2018	c.1538G>A	c.(1537-1539)aGc>aAc	p.S513N		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	513										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						AGGACCATCAGCGAGGACAGT	0.537000													21	145					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30624426	30624426	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30624426A>G	ENST00000376442.3	-	14	2454	c.2259T>C	c.(2257-2259)ccT>ccC	p.P753P	DHX16_ENST00000376437.5_Silent_p.P272P	NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	753	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						TCTGGATCTCAGGCACTGTGG	0.597000													20	128					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7011633	7011633	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:7011633T>C	ENST00000409757.4	+	10	1600	c.1476T>C	c.(1474-1476)agT>agC	p.S492S	TBC1D14_ENST00000451522.2_Silent_p.S212S|TBC1D14_ENST00000410031.1_Silent_p.S264S|TBC1D14_ENST00000446947.2_Silent_p.S139S|TBC1D14_ENST00000448507.1_Silent_p.S492S	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	492	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						TGTTGCACAGTATTTTGGGCG	0.373000													44	171					0	0	1	0	0
EIF5B	9669	broad.mit.edu	37	2	99977764	99977764	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99977764T>C	ENST00000289371.5	+	4	602	c.400T>C	c.(400-402)Tac>Cac	p.Y134H		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	134					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AGTGGAAATGTACTCTGGGAG	0.353000													31	82					0	0	1	0	0
SCAF8	22828	broad.mit.edu	37	6	155153834	155153834	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:155153834C>T	ENST00000367178.3	+	20	3697	c.3121C>T	c.(3121-3123)Cgg>Tgg	p.R1041W	SCAF8_ENST00000417268.1_Missense_Mutation_p.R1041W|TIAM2_ENST00000461783.3_5'UTR|SCAF8_ENST00000367186.4_Missense_Mutation_p.R1107W	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	1041	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						TGTGGTTGGGCGGCCTATAGA	0.483000													27	71					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916116	42916116	+	Missense_Mutation	SNP	G	G	A	rs141302264		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:42916116G>A	ENST00000316161.4	-	1	1517	c.1193C>T	c.(1192-1194)cCt>cTt	p.P398L	CYP8B1_ENST00000437102.1_Missense_Mutation_p.P398L|ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	398					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity	p.P398H(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		GGTGGGCTCAGGGTGGATGTC	0.547000													15	232					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43267405	43267405	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:43267405A>G	ENST00000372585.5	+	4	639	c.544A>G	c.(544-546)Acc>Gcc	p.T182A	SLC22A7_ENST00000487175.1_3'UTR|SLC22A7_ENST00000372589.3_Missense_Mutation_p.T180A|SLC22A7_ENST00000372574.3_Missense_Mutation_p.T180A	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	182						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CTACGTGAGTACCCTGGTGCT	0.577000													16	263					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7318086	7318086	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7318086G>A	ENST00000302926.2	+	4	836	c.763G>A	c.(763-765)Gac>Aac	p.D255N	NLGN2_ENST00000575301.1_Missense_Mutation_p.D255N	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	255					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				CTTTGGGGGCGACCCCGAGCG	0.612000													33	96					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41119873	41119873	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41119873A>G	ENST00000308370.7	+	21	2810	c.2810A>G	c.(2809-2811)aAc>aGc	p.N937S	LTBP4_ENST00000396819.3_Missense_Mutation_p.N870S|LTBP4_ENST00000204005.9_Missense_Mutation_p.N900S|LTBP4_ENST00000243562.9_Missense_Mutation_p.N35S|LTBP4_ENST00000545697.1_Missense_Mutation_p.N390S|LTBP4_ENST00000602240.1_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	937	Cys-rich.|EGF-like 11; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ATCTGTACCAACACCGACGGC	0.697000													8	53					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151784435	151784435	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:151784435G>A	ENST00000255262.3	-	1	405	c.240C>T	c.(238-240)acC>acT	p.T80T	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	80					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GGTAGTAGTTGGTGGGCGTCT	0.552000													44	117					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67029943	67029943	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:67029943T>C	ENST00000340001.4	-	9	1411	c.1200A>G	c.(1198-1200)atA>atG	p.I400M	ABCA9_ENST00000453985.2_Missense_Mutation_p.I400M|ABCA9_ENST00000370732.2_Missense_Mutation_p.I400M	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	400					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					AAAGAGTAGCTATTATGAGGT	0.323000													7	99					0	0	1	0	0
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:164038C>G	ENST00000377447.3	-	5	486		c.e5-1		CBWD1_ENST00000431099.2_Splice_Site|CBWD1_ENST00000314367.10_Splice_Site|CBWD1_ENST00000382447.4_Splice_Site|CBWD1_ENST00000377400.4_Splice_Site|CBWD1_ENST00000356521.4_Splice_Site			Q9BRT8	CBWD1_HUMAN	COBW domain containing 1								ATP binding|protein binding	p.?(2)		kidney(1)|lung(2)|ovary(1)|skin(1)	5	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCACTGCACCTGAAAATATA	0.284000													5	202					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10081025	10081025	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:10081025G>C	ENST00000287647.3	+	8	647	c.554G>C	c.(553-555)aGa>aCa	p.R185T	FANCD2_ENST00000383807.1_Missense_Mutation_p.R185T|FANCD2_ENST00000383806.1_Missense_Mutation_p.R185T|FANCD2_ENST00000438741.1_3'UTR|FANCD2_ENST00000431693.1_Missense_Mutation_p.R185T|FANCD2_ENST00000419585.1_Missense_Mutation_p.R185T	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	185	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGGCTTGACAGAGTTGTGGAT	0.358000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	24					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186303547	186303547	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:186303547G>A	ENST00000367478.3	-	36	5388	c.5092C>T	c.(5092-5094)Cgc>Tgc	p.R1698C		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1698					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity	p.R1699C(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ACCATTGGGCGGATACTAGCC	0.468000			T	NTRK1	papillary thyroid								29	67					0	0	1	0	0
PPP1R2	5504	broad.mit.edu	37	3	195269829	195269829	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:195269829G>A	ENST00000328432.3	-	1	380	c.20C>T	c.(19-21)tCg>tTg	p.S7L		NM_006241.4	NP_006232.1	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 2	7					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			endometrium(2)|kidney(1)|large_intestine(1)|urinary_tract(2)	6	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		GGGCCGGTGCGAGGCCGTCGA	0.662000													4	11					0	0	1	0	0
LONRF1	91694	broad.mit.edu	37	8	12595579	12595579	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:12595579A>G	ENST00000398246.3	-	4	1107	c.1038T>C	c.(1036-1038)tgT>tgC	p.C346C	LONRF1_ENST00000530693.1_5'UTR|LONRF1_ENST00000533751.1_5'UTR	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	346					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		TGTTTTTAGTACATGGTAATG	0.358000													18	78					0	0	1	0	0
PXMP2	5827	broad.mit.edu	37	12	133277861	133277861	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133277861C>T	ENST00000317479.3	+	4	490	c.425C>T	c.(424-426)gCc>gTc	p.A142V	PXMP2_ENST00000543589.1_Intron|RP13-672B3.2_ENST00000537262.1_Silent_p.R13R|PXMP2_ENST00000428960.2_Missense_Mutation_p.A49V|PXMP2_ENST00000545677.1_Silent_p.R13R|PXMP2_ENST00000539093.1_Silent_p.R13R	NM_018663.1	NP_061133.1	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	142						integral to membrane|peroxisomal membrane	protein binding			large_intestine(1)|liver(2)|lung(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		GCCTTCGCCGCCAAGATGAGG	0.597000													7	249					0	0	1	0	0
ASB8	140461	broad.mit.edu	37	12	48543375	48543375	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:48543375G>T	ENST00000317697.3	-	4	810	c.641C>A	c.(640-642)gCt>gAt	p.A214D	ASB8_ENST00000536953.1_3'UTR|ASB8_ENST00000537754.1_5'UTR|ASB8_ENST00000536549.1_Missense_Mutation_p.A214D	NM_024095.3	NP_077000.1	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box containing 8	214					intracellular signal transduction	cytoplasm|nucleus				breast(1)|kidney(2)|large_intestine(2)|lung(5)|soft_tissue(1)	11						GTGTCCAACAGCTCTGTGGAG	0.527000													31	118					1.39806e-14	1.46325e-14	1	1	0
ZBTB49	166793	broad.mit.edu	37	4	4304616	4304616	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:4304616A>G	ENST00000337872.4	+	3	1174	c.1053A>G	c.(1051-1053)caA>caG	p.Q351Q	ZBTB49_ENST00000538529.1_5'UTR|ZBTB49_ENST00000355834.3_Silent_p.Q351Q	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						CTAGCAGCCAAAGTGCTGAAG	0.443000													22	60					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151880197	151880197	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:151880197T>C	ENST00000355193.2	-	35	5345	c.5127A>G	c.(5125-5127)gtA>gtG	p.V1709V	KMT2C_ENST00000262189.6_Silent_p.V1709V					lysine (K)-specific methyltransferase 2C																		TTGACATCTGTACTTTATTAA	0.343000													34	378					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200944736	200944736	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:200944736G>A	ENST00000332129.2	-	32	4782	c.4466C>T	c.(4465-4467)cCg>cTg	p.P1489L	KIF21B_ENST00000461742.2_Missense_Mutation_p.P1502L|KIF21B_ENST00000360529.5_Missense_Mutation_p.P1489L|KIF21B_ENST00000422435.2_Missense_Mutation_p.P1502L	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1502					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.P1489L(1)		autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						ATCGTAGTGCGGGGGCTCGAA	0.612000													13	49					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74878310	74878310	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:74878310G>A	ENST00000569840.2	+	3	833	c.259G>A	c.(259-261)Gca>Aca	p.A87T	MGAT5B_ENST00000565675.1_Missense_Mutation_p.A87T|MGAT5B_ENST00000301618.4_Missense_Mutation_p.A87T|MGAT5B_ENST00000428789.2_Missense_Mutation_p.A98T|MGAT5B_ENST00000374998.3_3'UTR	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	87						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCGCATGGACGCACTGGCCAG	0.677000													21	41					0	0	1	0	0
PHYKPL	85007	broad.mit.edu	37	5	177658445	177658445	+	Missense_Mutation	SNP	C	C	A	rs149132993		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:177658445C>A	ENST00000308158.5	-	2	373	c.139G>T	c.(139-141)Ggg>Tgg	p.G47W	PHYKPL_ENST00000476170.2_Missense_Mutation_p.G47W	NM_153373.2	NP_699204.1			5-phosphohydroxy-L-lysine phospho-lyase																		TATTCTGCCCCCTGTTCATCG	0.557000													34	154					1.90571e-15	1.99736e-15	1	1	0
NOMO1	23420	broad.mit.edu	37	16	14989418	14989418	+	Silent	SNP	C	C	T	rs142020293		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:14989418C>T	ENST00000287667.7	+	31	3756	c.3585C>T	c.(3583-3585)cgC>cgT	p.R1195R		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1195			R -> G.			integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						AGGGAGTCCGCGCGCTCGGCC	0.547000													117	737					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71492878	71492878	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:71492878C>T	ENST00000304743.2	+	14	3674	c.3228C>T	c.(3226-3228)tgC>tgT	p.C1076C	PCNX_ENST00000238570.5_Silent_p.C1076C|PCNX_ENST00000439984.3_Silent_p.C965C	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1076						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTTATTTCTGCATATGTTGCG	0.348000													5	105					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24580231	24580231	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:24580231G>A	ENST00000358321.3	+	4	828	c.567G>A	c.(565-567)acG>acA	p.T189T		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	189					immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						CGCTGCCCACGCAGACCATCA	0.612000													26	70					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37603244	37603244	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:37603244G>A	ENST00000328544.3	-	2	1132	c.599C>T	c.(598-600)gCg>gTg	p.A200V	SSTR3_ENST00000402501.1_Missense_Mutation_p.A200V	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	200					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						TCGCCAGGCCGCCGCCGGCTC	0.682000													12	37					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161834	57161834	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:57161834T>C	ENST00000371244.4	+	6	854		c.e6+2			NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						AGACATAAGGTGATTTTTCTT	0.383000													5	150					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153795360	153795360	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:153795360G>C	ENST00000297107.6	+	11	1658	c.1521G>C	c.(1519-1521)tgG>tgC	p.W507C	SAP30L-AS1_ENST00000519727.1_RNA|GALNT10_ENST00000377657.3_Missense_Mutation_p.W180C|GALNT10_ENST00000377661.2_Missense_Mutation_p.W445C|SAP30L-AS1_ENST00000524264.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	507	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CCTTCACCTGGAGAGAGGACA	0.473000													49	158					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005594	74005594	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:74005594A>G	ENST00000301607.3	-	22	3945	c.3692T>C	c.(3691-3693)gTg>gCg	p.V1231A	EVPL_ENST00000586740.1_Missense_Mutation_p.V1253A	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1231	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CAGCTTCTCCACCTCCTTCTC	0.637000													41	110					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107583768	107583768	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:107583768A>G	ENST00000374736.3	-	20	3242	c.2848T>C	c.(2848-2850)Ttc>Ctc	p.F950L		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	950	ABC transporter 1.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTCGGGGGGAACAACCCGGTC	0.532000													6	53					0	0	1	0	0
GPR137B	7107	broad.mit.edu	37	1	236306300	236306300	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:236306300T>C	ENST00000366592.3	+	1	469	c.378T>C	c.(376-378)ttT>ttC	p.F126F	GPR137B_ENST00000366591.4_Silent_p.F126F	NM_003272.3	NP_003263.1	O60478	G137B_HUMAN	G protein-coupled receptor 137B	126						integral to plasma membrane|membrane fraction				endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GCCTGCAGTTTTTCACCCTCA	0.602000													7	177					0	0	1	0	0
NOL11	25926	broad.mit.edu	37	17	65714141	65714141	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:65714141G>A	ENST00000253247.4	+	1	193	c.78G>A	c.(76-78)gaG>gaA	p.E26E	NOL11_ENST00000535137.1_5'UTR|NOL11_ENST00000581966.1_3'UTR	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	26						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TAGGCGTGGAGCAGAGCGACA	0.552000											OREG0024682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	87					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542033	55542033	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:55542033G>A	ENST00000220676.1	+	4	5739	c.5591G>A	c.(5590-5592)tGc>tAc	p.C1864Y		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1864					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAAAGAGTATGCACATCTGTC	0.413000													9	66					0	0	1	0	0
ABHD16B	140701	broad.mit.edu	37	20	62493544	62493544	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62493544G>A	ENST00000369916.3	+	1	979	c.651G>A	c.(649-651)caG>caA	p.Q217Q		NM_080622.3	NP_542189.1	Q9H3Z7	ABHGB_HUMAN	abhydrolase domain containing 16B	217							hydrolase activity			endometrium(2)|kidney(1)|lung(3)	6						CCTTCCCTCAGCACGACGCCA	0.682000													6	31					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47308126	47308126	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:47308126A>G	ENST00000377065.4	-	5	1682	c.1043T>C	c.(1042-1044)aTt>aCt	p.I348T	ZNF41_ENST00000313116.7_Missense_Mutation_p.I348T|ZNF41_ENST00000397050.2_Missense_Mutation_p.I358T	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	390						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				CCCGGTATGAATTTTTTGATG	0.383000													14	34					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206230826	206230826	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:206230826T>C	ENST00000367126.4	+	2	1424	c.959T>C	c.(958-960)tTc>tCc	p.F320S		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	320					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity	p.F320Y(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	AATGTGGCTTTCACCATCTCT	0.557000													13	37					0	0	1	0	0
KCTD1	284252	broad.mit.edu	37	18	24035851	24035851	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:24035851C>T	ENST00000417602.1	-	5	2453	c.2454G>A	c.(2452-2454)ttG>ttA	p.L818L	KCTD1_ENST00000408011.3_Silent_p.L210L|KCTD1_ENST00000579973.1_Silent_p.L210L|KCTD1_ENST00000580059.1_Silent_p.L210L|KCTD1_ENST00000317932.7_Silent_p.L210L	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	210					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity	p.L210L(1)|p.L818L(1)		endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			CTCTTTGCTGCAACCTCTCGA	0.547000													21	47					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546979	2546979	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2546979C>T	ENST00000567020.1	+	2	970	c.830C>T	c.(829-831)gCg>gTg	p.A277V	TBC1D24_ENST00000434757.2_Missense_Mutation_p.A277V|TBC1D24_ENST00000293970.5_Missense_Mutation_p.A277V|RP11-20I23.1_ENST00000564543.1_Missense_Mutation_p.A277V	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	277					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						AGAGACATCGCGAAGACGGTG	0.612000													36	102					0	0	1	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51237699	51237699	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:51237699G>A	ENST00000551456.1	+	2	307	c.262G>A	c.(262-264)Gca>Aca	p.A88T	TMPRSS12_ENST00000398458.3_Missense_Mutation_p.A88T			Q86WS5	TMPSC_HUMAN	transmembrane (C-terminal) protease, serine 12	88	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	18						ACAAGCTGGCGCATGGCCGTG	0.488000													9	15					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208740	140208740	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140208740T>C	ENST00000529310.1	+	1	1178	c.1064T>C	c.(1063-1065)tTa>tCa	p.L355S	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.L355S|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGACTTCCTTATCCTTGCCT	0.502000													47	144					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50095330	50095330	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:50095330A>G	ENST00000443081.1	+	9	2386	c.1467A>G	c.(1465-1467)gaA>gaG	p.E489E	RBM6_ENST00000266022.4_Silent_p.E621E|RBM6_ENST00000539992.1_5'UTR|RBM6_ENST00000442092.1_Silent_p.E99E|RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000422955.1_Silent_p.E99E			P78332	RBM6_HUMAN	RNA binding motif protein 6	621	RRM.				RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AAAAGAGAGAAGCAGAAAGGT	0.527000													6	67					0	0	1	0	0
ELL3	80237	broad.mit.edu	37	15	44067752	44067752	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:44067752T>C	ENST00000319359.3	-	5	1181	c.540A>G	c.(538-540)tcA>tcG	p.S180S	RP11-296A16.1_ENST00000417761.2_3'UTR	NM_025165.2	NP_079441.1	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	180					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				cervix(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)	13		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		TGTGCTCCCTTGAGGATCCTG	0.522000											OREG0023092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	52					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55103988	55103988	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:55103988A>G	ENST00000491143.2	+	1	1072	c.1040A>G	c.(1039-1041)aAg>aGg	p.K347R		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	347					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GCGGAGCTGAAGCGCTACAGT	0.622000													11	35					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559268	129559268	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:129559268T>C	ENST00000422113.2	-	9	2778	c.2452A>G	c.(2452-2454)Atg>Gtg	p.M818V	TMEM132D_ENST00000389441.4_Missense_Mutation_p.M356V	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	818						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTGTTTTCCATGTGAACCCCT	0.488000													20	97					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55818975	55818975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:55818975C>T	ENST00000313833.4	+	2	2112	c.1867C>T	c.(1867-1869)Cga>Tga	p.R623*	FBXO34_ENST00000440021.1_Nonsense_Mutation_p.R623*	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	623	F-box.									breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						TCGCTGGGTTCGAGATCCACG	0.473000													35	60					0	0	1	0	0
GORAB	92344	broad.mit.edu	37	1	170513868	170513868	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:170513868A>G	ENST00000367763.3	+	4	639	c.619A>G	c.(619-621)Acc>Gcc	p.T207A	GORAB_ENST00000367762.1_Missense_Mutation_p.T207A	NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	207						Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						TCAGGCAGAGACCATGAAACT	0.413000													36	129					0	0	1	0	0
FBXO21	23014	broad.mit.edu	37	12	117612582	117612582	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:117612582A>G	ENST00000427718.2	-	5	687	c.613T>C	c.(613-615)Tac>Cac	p.Y205H	FBXO21_ENST00000330622.5_Missense_Mutation_p.Y205H|FBXO21_ENST00000549689.1_5'UTR	NM_015002.2|NM_033624.2	NP_055817.1|NP_296373.1	O94952	FBX21_HUMAN	F-box protein 21	205					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GGATTGCAGTACTGGTCAATA	0.428000													44	114					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7373421	7373421	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:7373421T>C	ENST00000502583.1	-	5	2195	c.1631A>G	c.(1630-1632)aAt>aGt	p.N544S	CAGE1_ENST00000338150.4_Missense_Mutation_p.N544S|CAGE1_ENST00000512086.1_Missense_Mutation_p.N544S|CAGE1_ENST00000379918.4_Missense_Mutation_p.N544S|CAGE1_ENST00000296742.7_Missense_Mutation_p.N408S	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	544										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					AAGTTTTGCATTCTCATTTTT	0.333000													11	33					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233392981	233392981	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233392981G>T	ENST00000258385.3	+	4	285	c.253G>T	c.(253-255)Gac>Tac	p.D85Y	CHRND_ENST00000536614.1_Missense_Mutation_p.D85Y|CHRND_ENST00000457943.2_5'UTR|CHRND_ENST00000543200.1_Missense_Mutation_p.D70Y	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	85					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GGGCTGGACAGACAACCGGCT	0.572000													12	58					1.08611e-07	1.11655e-07	1	1	0
POLR2A	5430	broad.mit.edu	37	17	7412422	7412422	+	Missense_Mutation	SNP	C	C	T	rs140375256		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7412422C>T	ENST00000322644.6	+	21	4024	c.3625C>T	c.(3625-3627)Ccc>Tcc	p.P1209S		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1209					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CCGAATCTCCCCCTGGCTGTT	0.542000													17	60					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31489200	31489200	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:31489200C>T	ENST00000322054.5	+	6	1523	c.1238C>T	c.(1237-1239)gCg>gTg	p.A413V	EHD3_ENST00000541626.1_3'UTR	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	413					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					AAGGGCGGAGCGTTCGAGGGC	0.637000													16	45					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559068	140559068	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140559068G>A	ENST00000239444.2	+	1	1698	c.1453G>A	c.(1453-1455)Gcc>Acc	p.A485T		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		485	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCACCAACGCCCAGGTCAC	0.652000													81	1744					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51983803	51983803	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:51983803G>A	ENST00000396477.4	+	2	290	c.269G>A	c.(268-270)gGc>gAc	p.G90D	CEACAM18_ENST00000451626.1_Missense_Mutation_p.G151D	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	151						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATGTACACTGGCAGGGAGAGA	0.552000													24	72					0	0	1	0	0
UAP1L1	91373	broad.mit.edu	37	9	139972841	139972841	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139972841C>T	ENST00000360271.3	+	1	249	c.13C>T	c.(13-15)Ccc>Tcc	p.P5S	UAP1L1_ENST00000476184.1_Intron|UAP1L1_ENST00000409858.3_Intron			Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	0							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GGGGCCTGGCCCCAGCCCCAA	0.726000													3	31					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44073331	44073331	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:44073331T>C	ENST00000272286.2	+	3	293	c.203T>C	c.(202-204)cTg>cCg	p.L68P		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	68	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTTGAGCAGCTGGCTCAGTTC	0.532000													33	82					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170802065	170802065	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:170802065T>C	ENST00000436636.2	-	26	3392	c.3048A>G	c.(3046-3048)gaA>gaG	p.E1016E	TNIK_ENST00000538048.1_Silent_p.E968E|TNIK_ENST00000341852.6_Silent_p.E932E|TNIK_ENST00000470834.1_Silent_p.E979E|TNIK_ENST00000369326.5_Silent_p.E994E|TNIK_ENST00000460047.1_Silent_p.E953E|TNIK_ENST00000488470.1_Silent_p.E961E|TNIK_ENST00000357327.5_Silent_p.E987E|TNIK_ENST00000284483.8_Silent_p.E1008E|TNIK_ENST00000475336.1_Silent_p.E924E	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1016	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCTTTCTTGCTTCATTGAGTT	0.378000													40	99					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013682	99013682	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99013682C>T	ENST00000393504.1	+	8	2466	c.2049C>T	c.(2047-2049)ccC>ccT	p.P683P	CNGA3_ENST00000272602.2_Silent_p.P683P|CNGA3_ENST00000409937.1_Silent_p.P687P|CNGA3_ENST00000436404.2_Silent_p.P665P	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	683					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GGGAAGTTCCCGGGGATGCTA	0.557000													19	46					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20441436	20441436	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:20441436C>T	ENST00000222573.3	+	10	2058	c.1374C>T	c.(1372-1374)acC>acT	p.T458T	ITGB8_ENST00000537992.1_Silent_p.T323T	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	458					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						TTAATGAAACCGCTAAAATTC	0.338000													22	101					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3768770	3768770	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:3768770G>A	ENST00000330055.5	+	1	646	c.437G>A	c.(436-438)aGc>aAc	p.S146N	ADRA2C_ENST00000509482.1_Missense_Mutation_p.S146N	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	146					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TGTGCCATCAGCCTGGACCGC	0.627000													5	62					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56480409	56480409	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56480409T>C	ENST00000267101.3	+	4	956	c.516T>C	c.(514-516)gcT>gcC	p.A172A	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Silent_p.A113A	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	172					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			ACCGAGATGCTGAGATAGTGG	0.493000													5	198					0	0	1	0	0
SIRT4	23409	broad.mit.edu	37	12	120750423	120750423	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120750423T>C	ENST00000202967.4	+	3	721	c.662T>C	c.(661-663)gTt>gCt	p.V221A	SIRT4_ENST00000537892.1_3'UTR	NM_012240.2	NP_036372.1	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	221	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAACCTGCGTTCAATGTGGA	0.542000													7	84					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648055	112648055	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:112648055A>G	ENST00000471858.1	-	3	665	c.433T>C	c.(433-435)Tat>Cat	p.Y145H	CD200R1_ENST00000490004.1_Missense_Mutation_p.Y145H|CD200R1_ENST00000295863.4_Missense_Mutation_p.Y123H|CD200R1_ENST00000308611.3_Missense_Mutation_p.Y168H|CD200R1_ENST00000440122.2_Missense_Mutation_p.Y168H	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	145	Ig-like C2-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TGGAGGTGATATCCACGATGG	0.418000													41	100					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31235598	31235598	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:31235598C>T	ENST00000322122.3	+	7	1240	c.956C>T	c.(955-957)cCg>cTg	p.P319L		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	319	B30.2/SPRY.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						CAGAAGGCGCCGCCGGCCGGG	0.706000													7	31					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156815812	156815812	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156815812T>C	ENST00000368195.3	-	9	2306	c.1910A>G	c.(1909-1911)tAc>tGc	p.Y637C	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	637	Fibronectin type-III 2.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CACCAGGTAGTAGGTGAGGTT	0.677000													15	45					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776763	5776763	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5776763C>T	ENST00000317254.3	+	1	841	c.793C>T	c.(793-795)Cgc>Tgc	p.R265C	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTTTTCCCACCGCTTTGGGGA	0.473000													34	143					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184297495	184297495	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:184297495C>T	ENST00000330394.2	+	11	2397	c.1945C>T	c.(1945-1947)Cgt>Tgt	p.R649C	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	649	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GGAAGTGTGCCGTGGTCGACT	0.612000													16	56					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61923013	61923013	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:61923013A>G	ENST00000325324.6	+	30	2965	c.2796A>G	c.(2794-2796)tcA>tcG	p.S932S	IPO11_ENST00000409534.1_Silent_p.S51S|IPO11_ENST00000409296.3_Silent_p.S972S|IPO11_ENST00000512177.1_3'UTR	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	932						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		ATACAGTGTCACTGCAGCAGT	0.483000													8	58					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154072543	154072543	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:154072543T>C	ENST00000368559.3	-	14	1967	c.1896A>G	c.(1894-1896)acA>acG	p.T632T	NUP210L_ENST00000271854.3_Silent_p.T632T	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	632						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TCACACTTACTGTTACCAGAG	0.398000													63	159					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65349638	65349638	+	Missense_Mutation	SNP	A	A	G	rs143804809		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:65349638A>G	ENST00000284037.5	+	21	2881	c.2492A>G	c.(2491-2493)cAg>cGg	p.Q831R	ERBB2IP_ENST00000380936.1_Missense_Mutation_p.Q831R|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.Q831R|ERBB2IP_ENST00000416865.2_Intron|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.Q831R|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.Q827R|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.Q831R|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.Q831R|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.Q831R|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.Q831R	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	831					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		GAAACTTCCCAGTCTCCTAAT	0.388000													10	29					0	0	1	0	0
TRMT1L	81627	broad.mit.edu	37	1	185125810	185125810	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:185125810A>G	ENST00000367506.5	-	1	303	c.35T>C	c.(34-36)cTg>cCg	p.L12P	TRMT1L_ENST00000367504.3_5'UTR	NM_001202423.1|NM_030934.4	NP_001189352.1|NP_112196.3	Q7Z2T5	TRM1L_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	12						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	21						CTCCTTCTCCAGGGGCAGCAG	0.716000													16	58					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3948355	3948355	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:3948355G>A	ENST00000313946.8	-	0	1232																											CTGCTCACCGGCCTCTGCCCG	0.642000													4	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179586855	179586855	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179586855T>C	ENST00000589042.1	-	78	22759	c.22535A>G	c.(22534-22536)aAg>aGg	p.K7512R	TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.K6268R|TTN_ENST00000591111.1_Missense_Mutation_p.K7195R|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7195	Ig-like 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGAGATTTCTTGGGTTCTGG	0.388000													8	232					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203383606	203383606	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:203383606C>T	ENST00000374580.4	+	6	1222	c.683C>T	c.(682-684)gCt>gTt	p.A228V	BMPR2_ENST00000374574.2_Missense_Mutation_p.A228V	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	228	Protein kinase.				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						CGTCCAGTTGCTGTAAAAGTG	0.398000													30	70					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770175	31770175	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:31770175G>A	ENST00000240587.4	-	2	851	c.524C>T	c.(523-525)aCg>aTg	p.T175M		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	175					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CTGCTGCAGCGTCTTAGCCAT	0.627000													16	33					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	868422	868422	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:868422T>C	ENST00000312090.6	-	16	2684	c.2534A>G	c.(2533-2535)aAc>aGc	p.N845S	MED16_ENST00000325464.1_Missense_Mutation_p.N826S|MED16_ENST00000269814.4_3'UTR|MED16_ENST00000589119.1_Missense_Mutation_p.N826S|MED16_ENST00000395808.3_Missense_Mutation_p.N826S			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	826					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACAGGCAGTTCTTGATCCA	0.667000													5	27					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77757830	77757830	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:77757830G>A	ENST00000310942.4	+	5	692	c.588G>A	c.(586-588)ccG>ccA	p.P196P		NM_005189.2	NP_005180.1	Q14781	CBX2_HUMAN	chromobox homolog 2	196					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TGGGGGCCCCGGCCAGCAAGC	0.701000													22	45					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76261120	76261120	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:76261120A>G	ENST00000529032.1	+	20	3899	c.3899A>G	c.(3898-3900)cAg>cGg	p.Q1300R	C11orf30_ENST00000343878.3_Missense_Mutation_p.Q1133R|C11orf30_ENST00000525919.1_Missense_Mutation_p.Q1301R|C11orf30_ENST00000533248.1_Missense_Mutation_p.Q1209R|C11orf30_ENST00000524490.1_Missense_Mutation_p.Q1202R|C11orf30_ENST00000524767.1_Missense_Mutation_p.Q1315R|C11orf30_ENST00000334736.3_Missense_Mutation_p.Q1300R|C11orf30_ENST00000525038.1_Missense_Mutation_p.Q1301R			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1300					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						GCAATGGAGCAGGACATAGAC	0.507000													19	49					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1232472	1232472	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:1232472T>C	ENST00000324642.3	+	2	422	c.299T>C	c.(298-300)gTa>gCa	p.V100A	SLC6A18_ENST00000296821.4_Missense_Mutation_p.V100A	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	100					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCAGTGGAGTAGGTAGGCCA	0.687000													3	23					0	0	1	0	0
METTL6	131965	broad.mit.edu	37	3	15467981	15467981	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:15467981A>G	ENST00000443029.1	-	2	278	c.38T>C	c.(37-39)aTt>aCt	p.I13T	METTL6_ENST00000383789.5_Missense_Mutation_p.I13T|METTL6_ENST00000383790.3_Missense_Mutation_p.I13T|METTL6_ENST00000450816.2_Missense_Mutation_p.I13T			Q8TCB7	METL6_HUMAN	methyltransferase like 6	13							methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(9)|lung(3)|prostate(1)	15						AGAGGTGAGAATCCTTGCCTG	0.408000													5	123					0	0	1	0	0
ZNF684	127396	broad.mit.edu	37	1	41012480	41012480	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:41012480G>A	ENST00000372699.3	+	5	736	c.485G>A	c.(484-486)aGt>aAt	p.S162N	ZNF684_ENST00000493756.1_3'UTR	NM_152373.3	NP_689586.3	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|lung(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			TATGAATGCAGTGAATGCGGG	0.308000													15	46					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34529731	34529731	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:34529731T>C	ENST00000354181.3	-	22	3315	c.2823A>G	c.(2821-2823)atA>atG	p.I941M	SLC12A6_ENST00000397702.2_Missense_Mutation_p.I882M|SLC12A6_ENST00000458406.2_Missense_Mutation_p.I882M|SLC12A6_ENST00000290209.5_Missense_Mutation_p.I890M|SLC12A6_ENST00000397707.2_Missense_Mutation_p.I926M|SLC12A6_ENST00000558589.1_Missense_Mutation_p.I932M|SLC12A6_ENST00000451844.2_Missense_Mutation_p.I753M|SLC12A6_ENST00000560611.1_Missense_Mutation_p.I941M|SLC12A6_ENST00000560164.1_Missense_Mutation_p.I753M|SLC12A6_ENST00000558667.1_Missense_Mutation_p.I941M			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	941					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	TGAAGATCCGTATGCTGCACT	0.433000													10	75					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	66986772	66986772	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66986772T>C	ENST00000529006.2	+	10	1301	c.855T>C	c.(853-855)gcT>gcC	p.A285A	KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_Silent_p.A285A	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	285	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						GGATTCATGCTGTGTATACTC	0.428000													8	28					0	0	1	0	0
GABARAPL2	11345	broad.mit.edu	37	16	75602095	75602095	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:75602095T>C	ENST00000037243.2	+	3	387	c.251T>C	c.(250-252)gTc>gCc	p.V84A	GABARAPL2_ENST00000565057.1_Missense_Mutation_p.V84A|RP11-77K12.8_ENST00000564489.1_RNA|GABARAPL2_ENST00000568455.1_Missense_Mutation_p.V24A|GABARAPL2_ENST00000563744.1_Intron	NM_007285.6	NP_009216.1	P60520	GBRL2_HUMAN	GABA(A) receptor-associated protein-like 2	84					autophagy|intra-Golgi vesicle-mediated transport|positive regulation of ATPase activity|protein transport	autophagic vacuole membrane|cytosol|Golgi membrane|membrane fraction	ATPase binding|beta-tubulin binding|GABA receptor binding|microtubule binding|SNARE binding			lung(1)|ovary(1)	2						GATAAGACAGTCCCACAGTCC	0.463000													40	113					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25981276	25981276	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:25981276T>C	ENST00000356865.6	-	3	778	c.667A>G	c.(667-669)Aat>Gat	p.N223D		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	223					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GTCAAAGGATTGAATTCGGAG	0.527000													5	26					0	0	1	0	0
EGLN2	112398	broad.mit.edu	37	19	41307039	41307039	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41307039T>C	ENST00000593726.1	+	1	1590	c.562T>C	c.(562-564)Tac>Cac	p.Y188H	EGLN2_ENST00000406058.2_Missense_Mutation_p.Y188H|EGLN2_ENST00000303961.4_Missense_Mutation_p.Y188H|RAB4B-EGLN2_ENST00000594136.1_3'UTR			Q96KS0	EGLN2_HUMAN	egl-9 family hypoxia-inducible factor 2	188					cell redox homeostasis|estrogen receptor signaling pathway|positive regulation of protein catabolic process|regulation of cell growth|response to hypoxia	cytoplasm|nucleus	ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxygen sensor activity			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Vitamin C(DB00126)	CTGCATGCGGTACTACGGCAT	0.687000													57	216					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3601144	3601144	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:3601144C>T	ENST00000302006.3	+	4	1485	c.1433C>T	c.(1432-1434)cCg>cTg	p.P478L		NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	478						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GCAGCCCTCCCGTCCGCCTGA	0.587000													18	56					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	205978293	205978293	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:205978293G>A	ENST00000406610.2	+	6	879	c.672G>A	c.(670-672)ctG>ctA	p.L224L	PARD3B_ENST00000358768.2_Silent_p.L224L|PARD3B_ENST00000462231.1_Silent_p.L224L|PARD3B_ENST00000349953.3_Silent_p.L224L|PARD3B_ENST00000351153.1_Silent_p.L224L	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	224	PDZ 1.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TTTCATCTCTGAGTGGAAGGT	0.408000													8	20					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167379617	167379617	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:167379617C>T	ENST00000519204.1	+	3	492	c.374C>T	c.(373-375)tCg>tTg	p.S125L	TENM2_ENST00000520394.1_Missense_Mutation_p.S55L|CTC-353G13.1_ENST00000523050.1_RNA|TENM2_ENST00000403607.2_Missense_Mutation_p.S79L|TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000518659.1_Missense_Mutation_p.S246L|TENM2_ENST00000545108.1_Missense_Mutation_p.S246L					teneurin transmembrane protein 2																		CACAGCCAGTCGACTCTGAGG	0.567000													5	30					0	0	1	0	0
PPP1R7	5510	broad.mit.edu	37	2	242105761	242105761	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:242105761C>T	ENST00000234038.6	+	8	1198	c.724C>T	c.(724-726)Ctg>Ttg	p.L242L	PPP1R7_ENST00000407025.1_Silent_p.L242L|PPP1R7_ENST00000272983.8_Silent_p.L199L|PPP1R7_ENST00000406106.3_Silent_p.L242L|PPP1R7_ENST00000404405.3_Silent_p.L236L|PPP1R7_ENST00000402734.1_Silent_p.L183L|PPP1R7_ENST00000485630.1_3'UTR|PPP1R7_ENST00000401987.1_Silent_p.L199L	NM_002712.1	NP_002703.1	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	242						cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)	23		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)		GAGCAACCGGCTGACCAAGAT	0.498000													9	31					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34096009	34096009	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:34096009C>T	ENST00000397527.1	+	32	7616	c.6896C>T	c.(6895-6897)aCc>aTc	p.T2299I	CEP250_ENST00000342580.4_Missense_Mutation_p.T2243I	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2299					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTGCGGAGTACCTTGGAGCAG	0.572000													46	138					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86474116	86474116	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:86474116G>C	ENST00000297814.2	-	14	3248	c.3105C>G	c.(3103-3105)caC>caG	p.H1035Q	RP11-575L7.4_ENST00000592283.1_RNA|RP11-575L7.4_ENST00000591217.1_RNA|RP11-575L7.4_ENST00000421734.3_RNA|RP11-575L7.4_ENST00000590368.1_RNA|RP11-575L7.4_ENST00000586206.1_RNA|RP11-575L7.4_ENST00000589233.1_RNA|RP11-575L7.4_ENST00000589817.1_RNA|RP11-575L7.4_ENST00000590417.1_RNA|KIF27_ENST00000334204.2_Missense_Mutation_p.H938Q|KIF27_ENST00000413982.1_Missense_Mutation_p.H969Q|RP11-575L7.4_ENST00000586211.1_RNA	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	1035					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						CATCCACATTGTGTCTGCGTT	0.413000													28	128					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64906957	64906957	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:64906957A>G	ENST00000555709.1	+	18	2175	c.1788A>G	c.(1786-1788)aaA>aaG	p.K596K	MTHFD1_ENST00000545908.1_Silent_p.K652K|CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000555252.1_Silent_p.K576K|MTHFD1_ENST00000216605.7_Silent_p.K652K	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	596	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CCAGTAAGAAAGGAGAGCCCG	0.512000													17	47					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979645	89979645	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:89979645T>C	ENST00000405460.2	+	28	6003	c.5907T>C	c.(5905-5907)gtT>gtC	p.V1969V		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1969					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CGTTAACAGTTTTGGCTAGTG	0.408000													13	18					0	0	1	0	0
LDHA	3939	broad.mit.edu	37	11	18428863	18428863	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18428863C>T	ENST00000396222.2	+	7	864	c.765C>T	c.(763-765)ggC>ggT	p.G255G	LDHA_ENST00000379412.5_3'UTR|LDHA_ENST00000540430.1_3'UTR|LDHA_ENST00000430553.2_3'UTR|LDHA_ENST00000422447.3_3'UTR|LDHA_ENST00000227157.4_3'UTR	NM_001165415.1	NP_001158887.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	0					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	ACTGTCTAGGCTACAACAGGA	0.398000													10	48					0	0	1	0	0
MUC5AC	4586	broad.mit.edu	37	11	1156656	1156656	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1156656T>A	ENST00000356191.2	+	10	665	c.665T>A	c.(664-666)cTc>cAc	p.L222H						mucin 5AC, oligomeric mucus/gel-forming											NS(1)|breast(2)|central_nervous_system(7)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(5)|kidney(9)|large_intestine(19)|liver(1)|lung(89)|ovary(7)|prostate(8)|skin(9)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	203		all_cancers(49;2.94e-05)|Breast(177;0.00257)|all_epithelial(84;0.00314)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00146)|Lung(200;0.0612)|LUSC - Lung squamous cell carcinoma(625;0.0724)		CGAGCTCCTCTCCCACAGTAA	0.617000													30	69					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1403878	1403878	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1403878C>T	ENST00000378785.2	+	12	2199	c.1204C>T	c.(1204-1206)Cct>Tct	p.P402S		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	402							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGGGAGAGGCCTGGGCCCGA	0.672000													8	34					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114484037	114484037	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:114484037T>C	ENST00000369558.1	+	2	1264	c.1032T>C	c.(1030-1032)gtT>gtC	p.V344V	HIPK1_ENST00000369554.2_Silent_p.V344V|HIPK1_ENST00000369555.2_Silent_p.V344V|HIPK1_ENST00000369561.4_Silent_p.V344V|HIPK1_ENST00000369559.4_Silent_p.V344V|HIPK1_ENST00000426820.2_Silent_p.V344V			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	344	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTAGTCACGTTTCCAAAGCTG	0.453000													54	161					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049492	70049492	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:70049492G>A	ENST00000330891.5	-	10	1428	c.1202C>T	c.(1201-1203)gCc>gTc	p.A401V	BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Missense_Mutation_p.A295V|BEST3_ENST00000488961.1_Missense_Mutation_p.A188V	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	401						chloride channel complex|plasma membrane	chloride channel activity	p.A188V(1)|p.A401V(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GTGTTCGTGGGCACTCAGGAA	0.562000													45	212					0	0	1	0	0
GNAT3	346562	broad.mit.edu	37	7	80091946	80091946	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:80091946T>C	ENST00000398291.3	-	6	685	c.590_splice	c.e6-1	p.M198_splice	CD36_ENST00000435819.1_Intron	NM_001102386.1	NP_001095856.1	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha transducing 3	198					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	9						ACATCAAACATCCTTTAAGAA	0.358000													10	40					0	0	1	0	0
MUC13	56667	broad.mit.edu	37	3	124646509	124646509	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:124646509A>G	ENST00000311075.3	-	2	419	c.381T>C	c.(379-381)gaT>gaC	p.D127D		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	127	Thr-rich.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						TGATTAATCCATCATTTGGAG	0.438000													75	222					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605944	179605944	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179605944T>C	ENST00000589042.1	-	48	12240	c.12016A>G	c.(12016-12018)Agt>Ggt	p.S4006G	TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S3643G|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S3689G|TTN_ENST00000359218.5_Missense_Mutation_p.S3768G|TTN_ENST00000342175.6_Missense_Mutation_p.S3835G|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3689							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGAGGCCACTGTCTTCCCTC	0.453000													38	93					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39284104	39284104	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:39284104T>C	ENST00000373229.5	-	5	789	c.776A>G	c.(775-777)cAc>cGc	p.H259R	KCNK16_ENST00000507712.1_Intron|KCNK16_ENST00000373227.4_Intron|KCNK16_ENST00000437525.2_Missense_Mutation_p.H259R|KCNK16_ENST00000425054.2_Intron	NM_032115.3	NP_115491.1	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	259						integral to membrane	potassium channel activity|voltage-gated ion channel activity			large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)	13						GCAGCATCTGTGCAGAAGCAG	0.637000													7	23					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17447030	17447030	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:17447030A>G	ENST00000541323.1	+	3	554	c.109A>G	c.(109-111)Aga>Gga	p.R37G	PDGFRL_ENST00000398074.3_Missense_Mutation_p.R37G|PDGFRL_ENST00000251630.6_Missense_Mutation_p.R37G	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	37						extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		AGGAGAGAATAGAATCAAACC	0.433000													64	233					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277353	186277353	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:186277353T>C	ENST00000445192.2	+	7	2547	c.2502T>C	c.(2500-2502)ccT>ccC	p.P834P	PRG4_ENST00000367484.3_Silent_p.P363P|PRG4_ENST00000367483.4_Silent_p.P793P|PRG4_ENST00000367486.3_Silent_p.P791P|PRG4_ENST00000367485.4_Silent_p.P741P	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	834	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CCAAGGAGCCTGCACCCACTA	0.577000													90	302					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37042542	37042542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:37042542G>T	ENST00000231790.2	+	3	520	c.304G>T	c.(304-306)Gag>Tag	p.E102*	MLH1_ENST00000536378.1_5'UTR|MLH1_ENST00000458205.2_5'UTR|MLH1_ENST00000492474.1_3'UTR|MLH1_ENST00000435176.1_Intron|MLH1_ENST00000455445.2_5'UTR|MLH1_ENST00000539477.1_5'UTR	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	102			E -> K (in HNPCC2; uncertain pathogenicity).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						CTTTCGAGGTGAGGTAAGCTA	0.348000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				35	28					6.53348e-20	6.88128e-20	1	1	0
SAMD9L	219285	broad.mit.edu	37	7	92760603	92760603	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:92760603T>C	ENST00000318238.4	-	5	5898	c.4682A>G	c.(4681-4683)aAc>aGc	p.N1561S	SAMD9L_ENST00000411955.1_Missense_Mutation_p.N1561S|SAMD9L_ENST00000437805.1_Missense_Mutation_p.N1561S	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1561										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCTTTCTATGTTCCTACCACT	0.363000													16	45					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555185	44555185	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:44555185C>T	ENST00000330682.2	-	1	1264	c.1029G>A	c.(1027-1029)cgG>cgA	p.R343R	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	343	Activation domain (By similarity).|Interaction with elongin BC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						TCCTAGGCACCCGGAGGCACT	0.652000													25	783					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53348085	53348085	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:53348085T>C	ENST00000395631.2	-	5	845	c.629A>G	c.(628-630)gAc>gGc	p.D210G	FERMT2_ENST00000399304.3_Missense_Mutation_p.D210G|FERMT2_ENST00000553373.1_Missense_Mutation_p.D210G|FERMT2_ENST00000343279.4_Missense_Mutation_p.D210G|FERMT2_ENST00000341590.3_Missense_Mutation_p.D210G			Q96AC1	FERM2_HUMAN	fermitin family member 2	210	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					CAAAGCACTGTCACCAAACCA	0.438000													4	213					0	0	1	0	0
FJX1	24147	broad.mit.edu	37	11	35640687	35640687	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:35640687T>C	ENST00000317811.4	+	1	953	c.503T>C	c.(502-504)cTg>cCg	p.L168P		NM_014344.3	NP_055159.2	Q86VR8	FJX1_HUMAN	four jointed box 1 (Drosophila)	168						extracellular space				lung(1)|urinary_tract(1)	2	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				TCCAACCGACTGGCCCGTTTT	0.726000													7	16					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140706049	140706049	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140706049A>G	ENST00000460843.1	+	19	2876	c.2849A>G	c.(2848-2850)aAc>aGc	p.N950S		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	950					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCCCGGGAGAACCGCTACGAC	0.647000													17	66					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951959	119951959	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:119951959C>T	ENST00000307142.4	+	4	2225	c.2029C>T	c.(2029-2031)Cca>Tca	p.P677S	SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.P677S|SYNPO2_ENST00000434046.2_Missense_Mutation_p.P677S	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	677						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GATCTCAGTGCCAGCAAAAAG	0.517000													12	70					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47034443	47034443	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:47034443C>T	ENST00000377604.3	+	6	1270	c.528C>T	c.(526-528)gtC>gtT	p.V176V	RBM10_ENST00000329236.7_Silent_p.V99V|RBM10_ENST00000468791.1_Intron|RBM10_ENST00000345781.6_Silent_p.V99V	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	176	RRM 1.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						TCGCCTTCGTCGAGTTTAGTC	0.552000													30	39					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149505380	149505380	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:149505380G>A	ENST00000378016.2	+	0	8938							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATGCACCTCGGAGCGCTGCCC	0.602000													36	140					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68695275	68695275	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:68695275T>C	ENST00000423218.2	-	2	241	c.146A>G	c.(145-147)gAc>gGc	p.D49G	ITGA11_ENST00000315757.7_Missense_Mutation_p.D49G			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	49					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GCCACTGATGTCGTGCTGCTG	0.627000													10	15					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118698771	118698771	+	Missense_Mutation	SNP	G	G	A	rs148434878		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:118698771G>A	ENST00000376300.2	-	19	1653	c.1516C>T	c.(1516-1518)Cgc>Tgc	p.R506C	CCDC93_ENST00000319432.5_Missense_Mutation_p.R505C	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	506										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						CTACTCTGGCGGTAGAGTTCA	0.498000													17	55					0	0	1	0	0
RNF148	378925	broad.mit.edu	37	7	122342612	122342612	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:122342612G>A	ENST00000434824.1	-	1	409	c.193C>T	c.(193-195)Cat>Tat	p.H65Y	CADPS2_ENST00000449022.2_Intron|RNF148_ENST00000447240.1_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000412584.2_Intron	NM_198085.1	NP_932351.1	Q8N7C7	RN148_HUMAN	ring finger protein 148	65	PA.					integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						AGAGGAGAATGATTCCCGAAC	0.473000													4	77					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256223	16256223	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16256223T>A	ENST00000375759.3	+	11	3692	c.3488T>A	c.(3487-3489)aTc>aAc	p.I1163N		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1163					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GGCATTGACATCGATCACACG	0.398000													7	47					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	38016099	38016099	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:38016099G>T	ENST00000377707.3	-	2	1312	c.747C>A	c.(745-747)ccC>ccA	p.P249P	SHB_ENST00000377700.4_Silent_p.P249P|RP11-613M10.9_ENST00000540557.1_Silent_p.P249P	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	249	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TGGCATCAAAGGGATCTGAGT	0.507000													42	109					1.59361e-14	1.66677e-14	1	1	0
B3GALNT2	148789	broad.mit.edu	37	1	235618984	235618984	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:235618984T>C	ENST00000366600.3	-	9	1266	c.1038A>G	c.(1036-1038)acA>acG	p.T346T		NM_152490.2	NP_689703.1	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	346					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			TGAAGCTCGTTGTTTCCACAG	0.403000													12	39					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586853	15586853	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:15586853A>G	ENST00000292609.4	-	2	757	c.628T>C	c.(628-630)Tcc>Ccc	p.S210P	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.S210P			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	210					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GTCGGTGGGGACTTGGCTTTG	0.577000													64	151					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3788663	3788663	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3788663T>C	ENST00000262367.5	-	26	5100	c.4291A>G	c.(4291-4293)Att>Gtt	p.I1431V	CREBBP_ENST00000382070.3_Missense_Mutation_p.I1393V	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1431	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGATAAGAAATGTACACACGC	0.418000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						12	25					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223568079	223568079	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:223568079A>G	ENST00000366875.3	+	1	1365	c.1262A>G	c.(1261-1263)gAc>gGc	p.D421G		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	421										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		AAGGTCCAGGACACCAACCTG	0.612000													10	54					0	0	1	0	0
SLC25A20	788	broad.mit.edu	37	3	48921521	48921521	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:48921521T>C	ENST00000319017.4	-	3	433	c.235A>G	c.(235-237)Atc>Gtc	p.I79V	SLC25A20_ENST00000430379.1_Intron|SLC25A20_ENST00000544097.1_Missense_Mutation_p.I29V	NM_000387.5	NP_000378.1	O43772	MCAT_HUMAN	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	79					carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	ACCCCGATGATAGGGGCAGCC	0.493000													15	60					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50868071	50868071	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:50868071T>C	ENST00000313478.7	-	32	4945	c.4664A>G	c.(4663-4665)tAt>tGt	p.Y1555C	TRPM7_ENST00000560955.1_Missense_Mutation_p.Y1554C|TRPM7_ENST00000561443.1_5'UTR	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1555					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		CTGACCTGAATAATAGTAATT	0.294000													4	46					0	0	1	0	0
GSK3B	2932	broad.mit.edu	37	3	119631553	119631553	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:119631553A>G	ENST00000264235.8	-	6	1695	c.713T>C	c.(712-714)aTa>aCa	p.I238T	GSK3B_ENST00000316626.5_Missense_Mutation_p.I238T	NM_001146156.1|NM_002093.3	NP_001139628.1|NP_002084.2	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta	238	Protein kinase.				axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding	p.I238T(2)		endometrium(1)|large_intestine(8)|lung(7)|prostate(2)	18				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	GTACTTACCTATACTAGAGGT	0.358000													8	24					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847832	95847832	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:95847832A>G	ENST00000398107.2	+	4	1655	c.1133A>G	c.(1132-1134)tAc>tGc	p.Y378C	ZNF2_ENST00000295210.6_Missense_Mutation_p.Y382C|ZNF2_ENST00000425369.1_Missense_Mutation_p.Y340C|ZNF2_ENST00000340539.5_Missense_Mutation_p.Y420C|ZNF2_ENST00000453539.2_Missense_Mutation_p.Y433C	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CAACGGCGTTACGCCAAACAG	0.453000													27	85					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573811	140573811	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140573811G>A	ENST00000239446.4	+	1	1870	c.1686G>A	c.(1684-1686)ctG>ctA	p.L562L		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		562					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTTCGTGCTGTACCCGCTGC	0.731000													24	129					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179463272	179463272	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179463272G>A	ENST00000589042.1	-	292	57296	c.57072C>T	c.(57070-57072)atC>atT	p.I19024I	TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Silent_p.I9959I|TTN_ENST00000342992.6_Silent_p.I16456I|TTN_ENST00000591111.1_Silent_p.I17383I|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Silent_p.I10084I|TTN_ENST00000342175.6_Silent_p.I10151I|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17383							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATATTCAACGATGTATCCAG	0.378000													11	32					0	0	1	0	0
INTS12	57117	broad.mit.edu	37	4	106604001	106604001	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:106604001G>A	ENST00000451321.2	-	7	1757	c.1278C>T	c.(1276-1278)agC>agT	p.S426S	INTS12_ENST00000394735.1_Silent_p.S426S|INTS12_ENST00000340139.5_Silent_p.S426S	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	426	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		CTGAGGGAGAGCTGCTGGATT	0.458000													46	179					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145838686	145838686	+	Silent	SNP	G	G	A	rs143032772		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:145838686G>A	ENST00000296702.5	+	4	716	c.678G>A	c.(676-678)caG>caA	p.Q226Q	TCERG1_ENST00000394421.2_Silent_p.Q226Q	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	226	Ala/Gln-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			cccaagcccaggcccaggctc	0.701000													17	41					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92187562	92187562	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:92187562T>C	ENST00000212355.4	-	8	1490	c.1025A>G	c.(1024-1026)tAc>tGc	p.Y342C	TGFBR3_ENST00000525962.1_Missense_Mutation_p.Y342C|TGFBR3_ENST00000370399.2_Missense_Mutation_p.Y342C	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	342					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		AGCCATTGTGTATGAAGTTAT	0.373000													13	43					0	0	1	0	0
COPS3	8533	broad.mit.edu	37	17	17150805	17150805	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:17150805A>G	ENST00000539941.2	-	11	1355	c.1147T>C	c.(1147-1149)Ttt>Ctt	p.F383L	COPS3_ENST00000439936.2_Missense_Mutation_p.F325L|COPS3_ENST00000268717.5_Missense_Mutation_p.F403L	NM_001199125.1	NP_001186054.1	Q9UNS2	CSN3_HUMAN	COP9 signalosome subunit 3	403					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			NS(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						TTTTGTACAAACTGAGGGTTC	0.493000													68	233					0	0	1	0	0
PRKX	5613	broad.mit.edu	37	X	3592653	3592653	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:3592653C>T	ENST00000262848.5	-	2	675	c.321G>A	c.(319-321)ccG>ccA	p.P107P		NM_005044.4	NP_005035.1	P51817	PRKX_HUMAN	protein kinase, X-linked	107	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(2)	12		all_lung(23;0.000396)|Lung NSC(23;0.00123)				TGATGAGGAACGGGTGGCTGA	0.562000													30	36					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1080085	1080085	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1080085C>T	ENST00000313093.2	+	13	1902	c.1671C>T	c.(1669-1671)taC>taT	p.Y557Y	HMHA1_ENST00000590577.1_Silent_p.Y192Y|HMHA1_ENST00000539243.2_Silent_p.Y573Y|HMHA1_ENST00000590214.1_Silent_p.Y584Y|HMHA1_ENST00000536472.1_Silent_p.Y397Y|HMHA1_ENST00000586866.1_Silent_p.Y561Y|HMHA1_ENST00000543365.1_Silent_p.Y440Y	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	557					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGTGCACTACGACTTTGAGC	0.672000													29	75					0	0	1	0	0
LSG1	55341	broad.mit.edu	37	3	194373792	194373792	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:194373792T>C	ENST00000265245.5	-	8	1153	c.839A>G	c.(838-840)cAc>cGc	p.H280R		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	280					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		GGATTCACTGTGGGAAATTTC	0.448000													37	100					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14105907	14105907	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:14105907A>G	ENST00000235372.7	+	8	2473	c.1617A>G	c.(1615-1617)gtA>gtG	p.V539V	PRDM2_ENST00000311066.5_Silent_p.V539V|PRDM2_ENST00000343137.4_Silent_p.V338V|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Silent_p.V338V	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	539				TQNVYVPSTEPEEEGEA -> PRTCMYQAQSRRGRGSR (in Ref. 4; AAA87023).		Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		ACGTGTATGTACCAAGCACAG	0.488000													11	70					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117280429	117280429	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:117280429C>A	ENST00000278935.3	+	30	3991	c.3844C>A	c.(3844-3846)Ctg>Atg	p.L1282M	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1282					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CCTCAGCATCCTGGACAGCCT	0.657000													104	266					7.73176e-47	8.20465e-47	1	1	0
KLK3	354	broad.mit.edu	37	19	51363282	51363282	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:51363282T>C	ENST00000326003.2	+	5	726	c.685T>C	c.(685-687)Tgg>Cgg	p.W229R	KLK3_ENST00000595952.1_Missense_Mutation_p.W186R|KLK3_ENST00000360617.3_3'UTR	NM_001030047.1|NM_001030048.1|NM_001648.2	NP_001025218.1|NP_001025219.1|NP_001639.1	P07288	KLK3_HUMAN	kallikrein-related peptidase 3	229	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		TATCACGTCATGGGGCAGTGA	0.547000													39	105					0	0	1	0	0
OR2AG2	338755	broad.mit.edu	37	11	6790040	6790040	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:6790040G>T	ENST00000338569.2	-	1	246	c.149C>A	c.(148-150)aCc>aAc	p.T50N		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGCTTCTATGGTGATGGCCAG	0.527000													28	114					2.41591e-17	2.54096e-17	1	1	0
UBE3B	89910	broad.mit.edu	37	12	109948151	109948151	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:109948151A>G	ENST00000342494.3	+	17	2339	c.1744A>G	c.(1744-1746)Aac>Gac	p.N582D	UBE3B_ENST00000434735.2_Missense_Mutation_p.N582D|UBE3B_ENST00000535900.1_3'UTR|UBE3B_ENST00000280774.5_Missense_Mutation_p.N582D	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	582					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						TCCCACAGAGAACGCCAAGGG	0.582000													7	16					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99012708	99012708	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99012708T>C	ENST00000393504.1	+	8	1492	c.1075T>C	c.(1075-1077)Tcc>Ccc	p.S359P	CNGA3_ENST00000272602.2_Missense_Mutation_p.S359P|CNGA3_ENST00000409937.1_Missense_Mutation_p.S363P|CNGA3_ENST00000436404.2_Missense_Mutation_p.S341P	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	359					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						TCTCTACTGGTCCACCTTGAC	0.502000													29	97					0	0	1	0	0
WDYHV1	55093	broad.mit.edu	37	8	124448756	124448756	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:124448756A>G	ENST00000523984.1	+	4	346	c.118A>G	c.(118-120)Act>Gct	p.T40A	WDYHV1_ENST00000523356.1_Missense_Mutation_p.T100A|WDYHV1_ENST00000518125.1_Intron|WDYHV1_ENST00000517609.1_3'UTR|WDYHV1_ENST00000287387.2_Missense_Mutation_p.T100A			Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	100					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(3)	17						TGATCTCGATACTGTCTTGCC	0.388000													19	92					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5014490	5014490	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:5014490G>A	ENST00000380872.4	+	6	860	c.668G>A	c.(667-669)cGa>cAa	p.R223Q	AKR1C1_ENST00000477661.1_3'UTR|AKR1C1_ENST00000434459.2_Missense_Mutation_p.R223Q	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						GGATCCCACCGAGAAGAACCA	0.408000													15	39					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584920	1584920	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:1584920C>T	ENST00000381297.4	-	2	742	c.532G>A	c.(532-534)Gtc>Atc	p.V178I		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	178						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACTTGAGGACGTCGAAGCAG	0.642000			T	CRLF2	"""B-ALL, Downs associated ALL"""								4	61					0	0	1	0	0
ZNF114	163071	broad.mit.edu	37	19	48789363	48789363	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:48789363A>G	ENST00000595607.1	+	6	976	c.482A>G	c.(481-483)aAt>aGt	p.N161S	ZNF114_ENST00000315849.1_Missense_Mutation_p.N161S|ZNF114_ENST00000597695.1_Missense_Mutation_p.N127S|ZNF114_ENST00000600687.1_Missense_Mutation_p.N161S			Q8NC26	ZN114_HUMAN	zinc finger protein 114	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)	18		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TTCAAGTATAATCCTGTCTTA	0.428000													31	58					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16245473	16245473	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16245473A>G	ENST00000375759.3	+	7	1652	c.1448A>G	c.(1447-1449)tAc>tGc	p.Y483C		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	483	RRM 3.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TTTCTGCAATACTGTGATATT	0.328000													15	42					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53330939	53330939	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:53330939G>C	ENST00000566029.1	+	30	5791	c.5582G>C	c.(5581-5583)aGa>aCa	p.R1861T	CHD9_ENST00000564845.1_Missense_Mutation_p.R1861T|CHD9_ENST00000447540.1_Missense_Mutation_p.R1861T|CHD9_ENST00000398510.3_Missense_Mutation_p.R1861T			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1861					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GACCCTGACAGAGGCCAATTT	0.353000													35	113					0	0	1	0	0
DPF1	8193	broad.mit.edu	37	19	38713318	38713318	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:38713318G>C	ENST00000416611.1	-	2	186	c.63C>G	c.(61-63)atC>atG	p.I21M	DPF1_ENST00000355526.4_Missense_Mutation_p.I47M|DPF1_ENST00000420980.2_Missense_Mutation_p.I47M|DPF1_ENST00000412732.1_De_novo_Start_InFrame|DPF1_ENST00000456296.1_Missense_Mutation_p.I21M|DPF1_ENST00000414789.1_De_novo_Start_InFrame			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	47					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GGCAGTGCTCGATGGCCTCGC	0.692000													7	21					0	0	1	0	0
GSS	2937	broad.mit.edu	37	20	33517351	33517351	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:33517351T>C	ENST00000216951.2	-	12	1252	c.1154A>G	c.(1153-1155)cAg>cGg	p.Q385R	GSS_ENST00000451957.2_Missense_Mutation_p.Q274R|GSS_ENST00000541098.1_Missense_Mutation_p.Q257R	NM_000178.2	NP_000169.1	P48637	GSHB_HUMAN	glutathione synthetase	385					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GTCCTTCAGCTGTTTCAGGGC	0.562000													8	361					0	0	1	0	0
DNAJB12	54788	broad.mit.edu	37	10	74104736	74104736	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:74104736T>C	ENST00000338820.3	-	2	534	c.385A>G	c.(385-387)Act>Gct	p.T129A	DNAJB12_ENST00000461919.1_Intron|DNAJB12_ENST00000444643.2_Missense_Mutation_p.T95A|DNAJB12_ENST00000394903.2_Missense_Mutation_p.T129A	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	95	J.				protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						TGTTCTGCAGTGTAGCCTTTG	0.607000													126	411					0	0	1	0	0
PYCR2	29920	broad.mit.edu	37	1	226109591	226109591	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:226109591G>A	ENST00000343818.6	-	4	655	c.507C>T	c.(505-507)gcC>gcT	p.A169A	RP4-559A3.7_ENST00000432920.2_Intron|PYCR2_ENST00000478402.1_5'UTR	NM_013328.2	NP_037460.2	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member 2	169					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity			kidney(1)|lung(3)	4	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	GCCCCGTGACGGCATCGATGA	0.647000													8	21					0	0	1	0	0
GMEB2	26205	broad.mit.edu	37	20	62224425	62224425	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62224425A>T	ENST00000266068.1	-	6	1108	c.630T>A	c.(628-630)tcT>tcA	p.S210S	GMEB2_ENST00000370069.1_Silent_p.S159S|GMEB2_ENST00000370077.1_Silent_p.S210S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	210					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			TGGTCGCAGGAGACCCATTCA	0.597000													3	19					0	0	1	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178080345	178080345	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:178080345T>A	ENST00000411529.2	+	2	136	c.85T>A	c.(85-87)Tta>Ata	p.L29I	HNRNPA3_ENST00000392524.2_Missense_Mutation_p.L51I|HNRNPA3_ENST00000435711.1_Missense_Mutation_p.L51I	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	51						catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						AGATGATAGTTTACGAGAACA	0.438000													18	118					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40339350	40339350	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:40339350G>A	ENST00000310169.2	+	3	473	c.334G>A	c.(334-336)Gtg>Atg	p.V112M	CHRNA9_ENST00000502377.1_3'UTR	NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	112					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	CAGTGACCTCGTGTGGAGGCC	0.468000													15	55					0	0	1	0	0
POP1	10940	broad.mit.edu	37	8	99146774	99146774	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:99146774T>C	ENST00000401707.2	+	7	979	c.898T>C	c.(898-900)Tat>Cat	p.Y300H	POP1_ENST00000349693.3_Missense_Mutation_p.Y300H	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	300					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GGTGAATAAATATCCCAGAGA	0.517000													34	104					0	0	1	0	0
PMS1	5378	broad.mit.edu	37	2	190660580	190660580	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:190660580A>T	ENST00000441310.2	+	3	451	c.218A>T	c.(217-219)tAc>tTc	p.Y73F	PMS1_ENST00000409823.3_Missense_Mutation_p.Y73F|PMS1_ENST00000418224.3_5'UTR|PMS1_ENST00000432292.3_Intron|PMS1_ENST00000421722.1_3'UTR|PMS1_ENST00000409985.1_Missense_Mutation_p.Y73F|PMS1_ENST00000374826.4_Missense_Mutation_p.Y73F|PMS1_ENST00000447232.2_Missense_Mutation_p.Y73F	NM_000534.4	NP_000525.1	P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	73					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GCAATGAAGTACTACACCTCA	0.383000			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					24	76					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110240845	110240845	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:110240845G>A	ENST00000418703.2	-	3	757	c.663C>T	c.(661-663)ggC>ggT	p.G221G	TRPV4_ENST00000541794.1_Silent_p.G221G|TRPV4_ENST00000392719.2_Silent_p.G221G|TRPV4_ENST00000346520.2_Silent_p.G221G|TRPV4_ENST00000261740.2_Silent_p.G221G|TRPV4_ENST00000537083.1_Silent_p.G221G|TRPV4_ENST00000536838.1_Silent_p.G187G|TRPV4_ENST00000544971.1_Silent_p.G221G	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	221					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						CCCTCATGTTGCCGGTGCGCT	0.632000													16	63					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5039883	5039883	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:5039883T>C	ENST00000159111.4	+	4	396	c.178T>C	c.(178-180)Tat>Cat	p.Y60H	KDM4B_ENST00000536461.1_Missense_Mutation_p.Y60H|KDM4B_ENST00000381759.4_Missense_Mutation_p.Y60H	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	60					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GCGGCAGACGTATGATGACAT	0.612000													22	121					0	0	1	0	0
SAP30L	79685	broad.mit.edu	37	5	153832994	153832994	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:153832994A>G	ENST00000297109.6	+	3	1005	c.357A>G	c.(355-357)ctA>ctG	p.L119L	SAP30L_ENST00000523198.1_3'UTR|SAP30L_ENST00000440364.2_Silent_p.L78L|SAP30L_ENST00000426761.2_Silent_p.L73L	NM_024632.5	NP_078908.1	Q9HAJ7	SP30L_HUMAN	SAP30-like	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|metal ion binding			breast(1)|lung(3)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			TGAACACCCTACGACGTTATA	0.483000													21	78					0	0	1	0	0
MRE11A	4361	broad.mit.edu	37	11	94179035	94179035	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:94179035G>A	ENST00000323929.3	-	16	2030	c.1808C>T	c.(1807-1809)aCc>aTc	p.T603I	MRE11A_ENST00000407439.3_Missense_Mutation_p.T606I|MRE11A_ENST00000323977.3_Intron|MRE11A_ENST00000393241.4_Missense_Mutation_p.T602I	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	603					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				CCTGCTACGGGTAGAAGTCTC	0.363000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				6	124					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93088587	93088587	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:93088587T>C	ENST00000298050.3	+	3	180	c.80T>C	c.(79-81)aTc>aCc	p.I27T	CCDC67_ENST00000530053.1_3'UTR|CCDC67_ENST00000527307.1_Missense_Mutation_p.I27T	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	27										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				CAAATTGACATCATGGTAAGC	0.388000													5	108					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68219108	68219108	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:68219108T>C	ENST00000347230.4	-	40	7462	c.7324A>G	c.(7324-7326)Acc>Gcc	p.T2442A	ZFYVE26_ENST00000557306.1_Missense_Mutation_p.T288A	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2442					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGGAGGATGGTGTCCCCGTCA	0.537000													4	21					0	0	1	0	0
MICA	100507436	broad.mit.edu	37	6	31379009	31379009	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31379009C>T	ENST00000449934.2	+	3	540	c.486C>T	c.(484-486)gcC>gcT	p.A162A	HCP5_ENST00000414046.2_RNA	NM_001177519.1	NP_001170990.1	Q29983	MICA_HUMAN	MHC class I polypeptide-related sequence A	162					antigen processing and presentation|cytolysis|defense response to bacterium|defense response to virus|gamma-delta T cell activation|immune response to tumor cell|response to DNA damage stimulus|response to heat|stimulatory C-type lectin receptor signaling pathway	cell surface|cytoplasm|extracellular space|integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			breast(1)|endometrium(3)|kidney(1)	5		Ovarian(999;0.0253)				AGACCTTGGCCATGAACGTCA	0.522000													5	24					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43912149	43912149	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43912149A>G	ENST00000339069.5	+	13	1459	c.828A>G	c.(826-828)gcA>gcG	p.A276A	CRHR1_ENST00000314537.5_3'UTR|CRHR1_ENST00000398285.3_3'UTR			P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	0					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		GTCATGGAGCAGCCCCCAAAG	0.642000													16	55					0	0	1	0	0
BRCC3	79184	broad.mit.edu	37	X	154305515	154305515	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:154305515G>A	ENST00000369462.1	+	4	291	c.266G>A	c.(265-267)cGa>cAa	p.R89Q	BRCC3_ENST00000369459.2_Missense_Mutation_p.R89Q|BRCC3_ENST00000340647.4_Missense_Mutation_p.R90Q|MTCP1_ENST00000362018.2_Intron|BRCC3_ENST00000330045.7_Missense_Mutation_p.R89Q|BRCC3_ENST00000399042.1_Missense_Mutation_p.R89Q	NM_024332.3	NP_077308.1	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	89					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|skin(1)	22	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGGAAGGACCGAGTAGAAATT	0.443000													23	31					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170322898	170322898	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:170322898T>C	ENST00000439128.2	-	31	4044	c.3404A>G	c.(3403-3405)aAc>aGc	p.N1135S	NEK1_ENST00000510533.1_Missense_Mutation_p.N1091S|NEK1_ENST00000507142.1_Missense_Mutation_p.N1163S|NEK1_ENST00000512193.1_Missense_Mutation_p.N1066S|NEK1_ENST00000511633.1_Missense_Mutation_p.N1119S	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1135					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CACATCACTGTTCTTCAAGAC	0.473000													7	258					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52417479	52417479	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52417479C>T	ENST00000420323.2	+	51	8280	c.8019C>T	c.(8017-8019)gaC>gaT	p.D2673D		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2673	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATACTGCGGACGAGCAGGACC	0.557000													16	38					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951562	235951562	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:235951562A>G	ENST00000409212.1	+	4	2656	c.2149A>G	c.(2149-2151)Aag>Gag	p.K717E	SH3BP4_ENST00000392011.2_Missense_Mutation_p.K717E|SH3BP4_ENST00000344528.4_Missense_Mutation_p.K717E			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	717					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CGTGCACACCAAGAACGTGCT	0.687000													25	86					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139222228	139222228	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:139222228T>C	ENST00000423192.1	+	20	2719	c.2558T>C	c.(2557-2559)tTa>tCa	p.L853S	ECT2L_ENST00000541398.1_Missense_Mutation_p.L707S|ECT2L_ENST00000367682.2_Missense_Mutation_p.L853S			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	853					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						CTTCATCGGTTACTCATAGAA	0.403000			"""N, Splice, Mis"""		ETP ALL								6	121					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127731634	127731634	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:127731634T>C	ENST00000368679.4	-	18	2397	c.2088A>G	c.(2086-2088)acA>acG	p.T696T	ADAM12_ENST00000368676.4_Silent_p.T696T	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	696					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GGCCGCTGTCTGTGCTTCCTC	0.637000													11	45					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321457	27321457	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:27321457G>A	ENST00000407991.1	-	6	1111	c.503C>T	c.(502-504)aCg>aTg	p.T168M	CHRNA2_ENST00000520933.2_Missense_Mutation_p.T168M|CHRNA2_ENST00000240132.2_Missense_Mutation_p.T153M	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	168						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	CACAGTGCCCGTGGAGAAGAG	0.597000													34	119					0	0	1	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56771216	56771216	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:56771216G>A	ENST00000413728.2	-	8	1599	c.1056C>T	c.(1054-1056)ggC>ggT	p.G352G	ARHGEF3_ENST00000496106.1_Silent_p.G352G|ARHGEF3_ENST00000338458.4_Silent_p.G378G|ARHGEF3_ENST00000296315.3_Silent_p.G346G|ARHGEF3_ENST00000497267.1_Silent_p.G317G|ARHGEF3_ENST00000495373.1_Silent_p.G346G	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	346	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		TACTTACCACGCCCCGATTGT	0.473000													34	112					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46292235	46292235	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:46292235T>C	ENST00000359930.4	-	16	3040	c.2189A>G	c.(2188-2190)cAc>cGc	p.H730R	SULF2_ENST00000361612.4_Missense_Mutation_p.H730R|SULF2_ENST00000467815.1_Missense_Mutation_p.H730R|SULF2_ENST00000484875.1_Missense_Mutation_p.H730R	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	730					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CTGGTTGTCGTGGGTGAAGCA	0.612000											OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	122					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49569252	49569252	+	Silent	SNP	G	G	A	rs143763229	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49569252G>A	ENST00000545947.1	+	6	2030	c.1308G>A	c.(1306-1308)acG>acA	p.T436T	DAG1_ENST00000538711.1_Silent_p.T436T|DAG1_ENST00000515359.2_Silent_p.T436T|DAG1_ENST00000541308.1_Silent_p.T436T|DAG1_ENST00000539901.1_Silent_p.T436T|DAG1_ENST00000308775.2_Silent_p.T436T	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	436	Mucin-like domain.|Thr-rich.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		AACCAGCAACGCCTTCAACTG	0.577000													27	121					0	0	1	0	0
TOMM70A	9868	broad.mit.edu	37	3	100087929	100087929	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:100087929T>C	ENST00000284320.5	-	10	1951	c.1503A>G	c.(1501-1503)aaA>aaG	p.K501K		NM_014820.4	NP_055635.3	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	501					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			endometrium(11)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	32						AATCAATACATTTATCATACA	0.313000													20	74					0	0	1	0	0
OR7A5	26659	broad.mit.edu	37	19	14938707	14938707	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14938707G>A	ENST00000322301.3	-	2	434	c.347C>T	c.(346-348)tCc>tTc	p.S116F	OR7A5_ENST00000601611.1_Intron|OR7A5_ENST00000594432.1_Missense_Mutation_p.S116F			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						GGCCATCACGGACAGGAGGAA	0.478000													41	91					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141643877	141643877	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:141643877G>T	ENST00000389484.3	-	24	4765	c.3794C>A	c.(3793-3795)tCt>tAt	p.S1265Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1265					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGACGAATAGAAAAGATGAT	0.308000										TSP Lung(27;0.18)			14	34					0.000219431	0.000222589	1	1	0
OR5D13	390142	broad.mit.edu	37	11	55541197	55541197	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:55541197C>G	ENST00000361760.1	+	1	284	c.284C>G	c.(283-285)tCt>tGt	p.S95C		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				AGAACCATCTCTTTCTCTGGT	0.403000													54	145					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198953648	198953648	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:198953648T>C	ENST00000428675.1	+	3	3180	c.2782T>C	c.(2782-2784)Tta>Cta	p.L928L	PLCL1_ENST00000437704.2_Silent_p.L830L	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	928					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GCAGTGCCTGTTAACTCTGTC	0.463000													148	415					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139918959	139918959	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:139918959T>C	ENST00000360839.2	+	34	7739	c.7585T>C	c.(7585-7587)Tgg>Cgg	p.W2529R	ANKHD1_ENST00000297183.6_Intron|ANKHD1-EIF4EBP3_ENST00000532219.1_Intron|ANKHD1_ENST00000544120.1_Missense_Mutation_p.W853R	NM_017747.2	NP_060217.1			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTGGCACGTGGGCACCTCA	0.363000													48	147					0	0	1	0	0
GJB4	127534	broad.mit.edu	37	1	35226920	35226920	+	Missense_Mutation	SNP	G	G	A	rs80358212		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35226920G>A	ENST00000339480.1	+	2	435	c.65G>A	c.(64-66)cGc>cAc	p.R22H		NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	22					cell communication	connexon complex|integral to membrane	gap junction channel activity	p.R22L(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GTGCTGAGCCGCATCTGGCTG	0.577000													14	40					0	0	1	0	0
SMDT1	91689	broad.mit.edu	37	22	42477930	42477930	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:42477930T>C	ENST00000331479.3	+	2	262	c.186_splice	c.e2-1	p.M63_splice	SMDT1_ENST00000547929.1_Intron	NM_033318.4	NP_201575.3			single-pass membrane protein with aspartate-rich tail 1																		CCTCTGCAGATGTCCTTCGGC	0.532000													14	63					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123089166	123089166	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123089166A>G	ENST00000333479.7	+	49	5334	c.5157A>G	c.(5155-5157)ctA>ctG	p.L1719L	KNTC1_ENST00000436959.3_5'UTR|KNTC1_ENST00000537348.1_Silent_p.L144L|KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1719					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AGAGATGGCTACAGAATATCC	0.343000													14	49					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166164384	166164384	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:166164384C>T	ENST00000375437.2	+	4	703	c.413C>T	c.(412-414)aCg>aTg	p.T138M	SCN2A_ENST00000283256.6_Missense_Mutation_p.T138M|SCN2A_ENST00000375427.2_Missense_Mutation_p.T138M|SCN2A_ENST00000357398.3_Missense_Mutation_p.T138M	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	138					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	ATTATGTGCACGATTCTTACC	0.353000													39	169					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33135624	33135624	+	Missense_Mutation	SNP	C	C	T	rs149442180		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:33135624C>T	ENST00000342462.4	-	2	254	c.64G>A	c.(64-66)Gtg>Atg	p.V22M	GLB1_ENST00000307377.8_Intron|TMPPE_ENST00000416695.2_Intron|GLB1_ENST00000307363.5_Intron|GLB1_ENST00000399402.3_Intron|GLB1_ENST00000445488.2_Intron	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	22						integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						ATCATGGACACGAAGACAGTG	0.597000													20	101					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18735645	18735645	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18735645T>C	ENST00000513874.1	-	14	1988	c.1849A>G	c.(1849-1851)Atc>Gtc	p.I617V	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	617	Ig-like 4.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TTCACAGTGATGGCGTGCGCA	0.612000													35	101					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153909067	153909067	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:153909067T>C	ENST00000361217.4	-	16	2808	c.2390A>G	c.(2389-2391)tAc>tGc	p.Y797C		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	797										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGCACATGGTAGGCTGTGTG	0.627000													11	25					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62962079	62962079	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:62962079A>G	ENST00000251157.5	-	38	4860	c.4827T>C	c.(4825-4827)cgT>cgC	p.R1609R	DOCK7_ENST00000340370.5_Silent_p.R1587R	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1618	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TCTTTAGAGAACGTCTTAAGA	0.373000													13	51					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926967	1926967	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:1926967C>T	ENST00000399161.2	-	10	1321	c.574G>A	c.(574-576)Gac>Aac	p.D192N	MYT1L_ENST00000428368.2_Missense_Mutation_p.D192N	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	192					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCATATTCGTCATTATTGTTA	0.383000													6	19					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28420789	28420789	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:28420789A>G	ENST00000261609.7	-	64	9808	c.9700T>C	c.(9700-9702)Tac>Cac	p.Y3234H		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3234					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AATCTGAAGTAATCCCCCTTT	0.532000													19	41					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87379725	87379725	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:87379725A>G	ENST00000327946.7	-	14	2344	c.2259T>C	c.(2257-2259)gaT>gaC	p.D753D	GRID1_ENST00000536331.1_Silent_p.D324D	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	753						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGCAGTCGTCATCCGTCAGGG	0.562000										Multiple Myeloma(13;0.14)			20	59					0	0	1	0	0
MTG2	26164	broad.mit.edu	37	20	60774252	60774252	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:60774252G>A	ENST00000370823.3	+	6	783	c.765G>A	c.(763-765)ccG>ccA	p.P255P	MTG2_ENST00000436421.2_Intron|MTG2_ENST00000536470.1_Silent_p.P27P	NM_015666.3	NP_056481.1			mitochondrial ribosome-associated GTPase 2																		CTTCCTACCCGTTCACCACCC	0.562000													19	39					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16338609	16338609	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:16338609T>C	ENST00000400202.1	-	3	2617	c.1905A>G	c.(1903-1905)gcA>gcG	p.A635A	NRIP1_ENST00000400199.1_Silent_p.A635A|NRIP1_ENST00000318948.4_Silent_p.A635A			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	635	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TTCCACATTGTGCTAAATTTT	0.428000													33	95					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729402	62729402	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62729402G>A	ENST00000349451.3	+	5	893	c.481G>A	c.(481-483)Gtc>Atc	p.V161I	OPRL1_ENST00000336866.2_Missense_Mutation_p.V161I|OPRL1_ENST00000355631.4_Missense_Mutation_p.V161I	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	161					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TGCCCTCGACGTCCGCACGTC	0.587000													33	94					0	0	1	0	0
GGA1	26088	broad.mit.edu	37	22	38026098	38026098	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:38026098A>G	ENST00000406772.1	+	14	1685	c.1033A>G	c.(1033-1035)Agc>Ggc	p.S345G	GGA1_ENST00000343632.4_Missense_Mutation_p.S418G|GGA1_ENST00000337437.4_Missense_Mutation_p.S385G|GGA1_ENST00000325180.8_Missense_Mutation_p.S331G|GGA1_ENST00000381756.5_Missense_Mutation_p.S435G	NM_001172688.1	NP_001166159.1	Q9UJY5	GGA1_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	418	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	10	Melanoma(58;0.0574)					GCCAGCAAGCAGCGGTCTGGA	0.682000													32	108					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197639891	197639891	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:197639891C>G	ENST00000263956.3	-	13	1869	c.1780G>C	c.(1780-1782)Gac>Cac	p.D594H		NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	594						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						GATATTTTGTCTCTCGATACT	0.338000													12	48					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33604771	33604771	+	Missense_Mutation	SNP	C	C	T	rs139888183		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:33604771C>T	ENST00000170564.2	+	14	2305	c.1991C>T	c.(1990-1992)gCa>gTa	p.A664V		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	664						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					ACCACTCAAGCATCAAGTGAA	0.527000													9	43					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53213631	53213631	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:53213631T>C	ENST00000394729.2	+	3	482	c.154T>C	c.(154-156)Tat>Cat	p.Y52H	PRKCD_ENST00000330452.3_Missense_Mutation_p.Y52H	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	52	C2.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GCCGACCATGTATCCTGAGTG	0.582000													11	20					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125434989	125434989	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:125434989G>A	ENST00000308736.2	-	23	3189	c.3091C>T	c.(3091-3093)Cgg>Tgg	p.R1031W	DHX37_ENST00000544745.1_Missense_Mutation_p.R818W	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	1031							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CACAGCACCCGCCCCCGCTCG	0.657000													8	50					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20457913	20457913	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:20457913G>A	ENST00000426804.1	-	1	3873	c.3389C>T	c.(3388-3390)gCa>gTa	p.A1130V		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AAGCCCATCTGCATACACAGC	0.582000													5	32					0	0	1	0	0
CENPV	201161	broad.mit.edu	37	17	16256481	16256481	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:16256481C>T	ENST00000299736.4	-	1	332	c.270G>A	c.(268-270)ccG>ccA	p.P90P	CENPV_ENST00000476243.1_5'UTR	NM_181716.2	NP_859067.2	Q7Z7K6	CENPV_HUMAN	centromere protein V	93	Pro-rich.				cell division|centromeric heterochromatin formation|mitosis|positive regulation of cytokinesis|regulation of chromosome organization	condensed chromosome kinetochore|cytoplasm|nucleus|spindle midzone	carbon-sulfur lyase activity			endometrium(1)|large_intestine(2)	3						gcggcggcggcggcggtggcg	0.776000													5	12					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176316708	176316708	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:176316708G>A	ENST00000292432.5	-	7	759	c.668C>T	c.(667-669)aCa>aTa	p.T223I		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	223	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGTGCCCACTGTGTCGTTCAC	0.592000													5	97					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68822243	68822243	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:68822243T>C	ENST00000294309.3	+	3	330	c.229T>C	c.(229-231)Tat>Cat	p.Y77H	TPCN2_ENST00000542467.1_Missense_Mutation_p.Y77H	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	77					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTACCGACGGTATTACTCGAA	0.592000													8	28					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216498739	216498739	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:216498739C>A	ENST00000366943.2	-	6	1437	c.1051G>T	c.(1051-1053)Ggt>Tgt	p.G351C	USH2A_ENST00000307340.3_Missense_Mutation_p.G351C|USH2A_ENST00000366942.3_Missense_Mutation_p.G351C			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	351	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATGAAGTACCAACATCATTA	0.388000										HNSCC(13;0.011)			16	76					1.02788e-11	1.06863e-11	1	1	0
LYRM4	57128	broad.mit.edu	37	6	5109669	5109669	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:5109669C>T	ENST00000330636.4	-	3	469	c.264G>A	c.(262-264)atG>atA	p.M88I	LYRM4_ENST00000464010.1_3'UTR|LYRM4_ENST00000468929.1_3'UTR	NM_020408.4	NP_065141.3	Q9HD34	LYRM4_HUMAN	LYR motif containing 4	88						mitochondrion|nucleus				endometrium(1)	1	Ovarian(93;0.11)	all_hematologic(90;0.0901)				AGGTCCTGGGCATGTCTCGAT	0.552000													7	198					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72829090	72829090	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:72829090C>T	ENST00000268489.5	-	9	8163	c.7491G>A	c.(7489-7491)tcG>tcA	p.S2497S	ZFHX3_ENST00000397992.5_Silent_p.S1583S	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2497					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GACTGGGGCTCGACTGGGGTA	0.632000													25	73					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55593505	55593505	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55593505A>G	ENST00000201647.6	+	10	1003	c.947A>G	c.(946-948)tAc>tGc	p.Y316C	EPS8L1_ENST00000588359.1_Intron|EPS8L1_ENST00000245618.5_Missense_Mutation_p.Y189C|EPS8L1_ENST00000586329.1_Missense_Mutation_p.Y298C|EPS8L1_ENST00000540810.1_Missense_Mutation_p.Y252C|EPS8L1_ENST00000592824.1_3'UTR	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	316						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GAGGCCGAGTACACCGACGTG	0.731000													6	18					0	0	1	0	0
CHST3	9469	broad.mit.edu	37	10	73767557	73767557	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:73767557C>T	ENST00000373115.4	+	3	1205	c.768C>T	c.(766-768)aaC>aaT	p.N256N		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	256					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						GCCCCCTCAACGTGACGCTGG	0.682000													8	18					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36934500	36934500	+	Silent	SNP	G	G	A	rs140840691		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:36934500G>A	ENST00000310758.4	-	17	2207	c.1560C>T	c.(1558-1560)tcC>tcT	p.S520S	ELMO1_ENST00000341056.3_Silent_p.S222S|ELMO1_ENST00000396045.3_Silent_p.S40S|ELMO1_ENST00000448602.1_Silent_p.S520S|ELMO1_ENST00000396040.2_Silent_p.S40S|ELMO1_ENST00000442504.1_Silent_p.S520S	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	520					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding	p.S520S(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TCATCCTCTCGGACTGGCGGA	0.463000													24	64					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214061	140214061	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140214061C>T	ENST00000525929.1	+	1	93	c.93C>T	c.(91-93)ctC>ctT	p.L31L	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.L31L|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGCCAGCTCCACTACTCGG	0.597000													40	125					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1818499	1818499	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:1818499T>C	ENST00000302787.2	-	12	2182	c.1886A>G	c.(1885-1887)gAc>gGc	p.D629G		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	629					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			AGCCTGCTGGTCCATCTCCAG	0.592000													30	82					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65007834	65007834	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:65007834A>G	ENST00000247207.6	+	1	649	c.267A>G	c.(265-267)aaA>aaG	p.K89K	HSPA2_ENST00000554883.1_Intron|HSPA2_ENST00000394709.1_Silent_p.K89K	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	89					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CGGATATGAAACACTGGCCGT	0.557000													18	55					0	0	1	0	0
FAM89A	375061	broad.mit.edu	37	1	231155818	231155818	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:231155818C>T	ENST00000366654.4	-	2	380	c.346G>A	c.(346-348)Gag>Aag	p.E116K	FAM89A_ENST00000494111.1_5'UTR	NM_198552.2	NP_940954.1	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	116										endometrium(1)|upper_aerodigestive_tract(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TGAATCGACTCGTAGAGGCTG	0.547000													22	55					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32595759	32595759	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:32595759C>T	ENST00000286827.3	-	9	2429	c.1958G>A	c.(1957-1959)cGc>cAc	p.R653H	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Missense_Mutation_p.R653H	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	653					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity	p.R653H(2)		autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GATTCCAAGGCGGCCCATGGC	0.483000													12	128					0	0	1	0	0
UCP3	7352	broad.mit.edu	37	11	73716870	73716870	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:73716870T>C	ENST00000314032.4	-	4	998	c.446A>G	c.(445-447)cAc>cGc	p.H149R	UCP3_ENST00000348534.4_Intron|UCP3_ENST00000426995.2_Missense_Mutation_p.H149R	NM_003356.3	NP_003347.1	P55916	UCP3_HUMAN	uncoupling protein 3 (mitochondrial, proton carrier)	149					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	12	Breast(11;2.08e-05)					TGGCCCGAGGTGTATGCTGGC	0.602000													9	96					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342617	29342617	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:29342617T>C	ENST00000396806.3	-	1	451	c.448A>G	c.(448-450)Agc>Ggc	p.S150G	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						TAAAAGAAGCTGATGAGCCAG	0.493000													21	64					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125853841	125853841	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:125853841C>T	ENST00000392693.3	-	16	3048	c.2921G>A	c.(2920-2922)gGc>gAc	p.G974D	CDON_ENST00000263577.7_Missense_Mutation_p.G974D|CDON_ENST00000531738.1_Missense_Mutation_p.G351D	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	974					cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GACCATGACGCCCAGCACACA	0.478000													14	47					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70011921	70011921	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:70011921A>G	ENST00000325845.7	-	26	2673	c.604T>C	c.(604-606)Ttt>Ctt	p.F202L	PDXDC2P_ENST00000531894.1_RNA|RP11-419C5.2_ENST00000532298.1_Intron|RP11-419C5.2_ENST00000525562.1_5'UTR																breast(2)|endometrium(2)|kidney(6)|lung(2)|prostate(1)	13						AGGGAGAAAAATGTATCCATG	0.502000													20	67					0	0	1	0	0
ZNF641	121274	broad.mit.edu	37	12	48737161	48737161	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:48737161T>C	ENST00000544117.2	-	6	1620	c.912A>G	c.(910-912)agA>agG	p.R304R	ZNF641_ENST00000301042.3_Silent_p.R304R|ZNF641_ENST00000547026.1_Silent_p.R290R|ZNF641_ENST00000448928.3_Silent_p.R281R			Q96N77	ZN641_HUMAN	zinc finger protein 641	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	12						TGAGGTGATGTCTTCGCCCAA	0.527000													4	174					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35365747	35365747	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35365747C>T	ENST00000373347.1	-	4	1503	c.1235G>A	c.(1234-1236)aGc>aAc	p.S412N	DLGAP3_ENST00000235180.4_Missense_Mutation_p.S412N			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	412					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				TGTCTTGGGGCTGCCGTCTGA	0.657000													11	175					0	0	1	0	0
ABHD8	79575	broad.mit.edu	37	19	17405647	17405647	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17405647A>G	ENST00000247706.3	-	3	1008	c.769T>C	c.(769-771)Ttc>Ctc	p.F257L	MRPL34_ENST00000595444.1_Intron|MRPL34_ENST00000600434.1_Intron	NM_024527.4	NP_078803.4	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	257							hydrolase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	9						AATGTGCAGAAAGAGACACTG	0.527000													12	44					0	0	1	0	0
BTBD9	114781	broad.mit.edu	37	6	38548147	38548147	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:38548147G>A	ENST00000481247.1	-	5	1032	c.881C>T	c.(880-882)gCc>gTc	p.A294V	BTBD9_ENST00000403056.1_Missense_Mutation_p.A294V|BTBD9_ENST00000314100.6_Missense_Mutation_p.A226V|BTBD9_ENST00000419706.2_Missense_Mutation_p.A235V|BTBD9_ENST00000408958.1_Missense_Mutation_p.A226V	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	294					cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						ATCTAATAAGGCTGATTTCAG	0.388000													36	121					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183885723	183885723	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:183885723C>T	ENST00000304685.3	+	17	2458	c.1997C>T	c.(1996-1998)aCg>aTg	p.T666M	RGL1_ENST00000536277.1_Missense_Mutation_p.T629M|RGL1_ENST00000539189.1_Missense_Mutation_p.T602M|RGL1_ENST00000360851.3_Missense_Mutation_p.T631M|RGL1_ENST00000367531.1_Missense_Mutation_p.T666M	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	631	Ras-associating.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity	p.T666M(1)		breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						GTCTCGGTGACGTCCATTACC	0.502000													54	114					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17589322	17589322	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:17589322G>A	ENST00000319363.6	+	13	1346	c.1213G>A	c.(1213-1215)Gcc>Acc	p.A405T		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	405	SEFIR.				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CCTGCTCACCGCCTGCGGCAC	0.637000													22	59					0	0	1	0	0
UQCRC2	7385	broad.mit.edu	37	16	21994469	21994469	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:21994469A>G	ENST00000268379.4	+	14	2103	c.1339A>G	c.(1339-1341)Aca>Gca	p.T447A	UQCRC2_ENST00000561553.1_Missense_Mutation_p.I395M	NM_003366.2	NP_003357.2	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	447					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15				GBM - Glioblastoma multiforme(48;0.0264)		TTTGGGACATACACCTTTTGT	0.393000													4	77					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57485765	57485765	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:57485765C>T	ENST00000371100.4	+	13	3547	c.2995C>T	c.(2995-2997)Cgt>Tgt	p.R999C	GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000371085.3_Missense_Mutation_p.R356C|GNAS_ENST00000354359.7_Missense_Mutation_p.R357C|GNAS_ENST00000371102.4_Missense_Mutation_p.R985C|GNAS_ENST00000371095.3_Missense_Mutation_p.R342C|GNAS_ENST00000265620.7_Missense_Mutation_p.R341C|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000306090.10_Missense_Mutation_p.R342C	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	356					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TGGAGATGGGCGTCACTACTG	0.577000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			15	48					0	0	1	0	0
AGTRAP	57085	broad.mit.edu	37	1	11808623	11808623	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:11808623A>G	ENST00000314340.5	+	4	374	c.320A>G	c.(319-321)tAc>tGc	p.Y107C	AGTRAP_ENST00000452018.2_Silent_p.L139L|AGTRAP_ENST00000491346.1_3'UTR|AGTRAP_ENST00000376629.4_Missense_Mutation_p.Y107C|AGTRAP_ENST00000400895.2_Silent_p.L139L|AGTRAP_ENST00000376627.2_Silent_p.L151L|AGTRAP_ENST00000510878.1_Missense_Mutation_p.T72A|AGTRAP_ENST00000376637.3_Silent_p.L95L	NM_020350.4	NP_065083.3	Q6RW13	ATRAP_HUMAN	angiotensin II receptor-associated protein	107						cytoplasmic vesicle membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding		AGTRAP/BRAF(2)	endometrium(1)|lung(3)|prostate(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.46e-06)|COAD - Colon adenocarcinoma(227;0.000256)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTTCGTCTACCACATGTAC	0.657000													10	63					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100363565	100363565	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:100363565T>C	ENST00000262233.6	+	7	900	c.761T>C	c.(760-762)gTg>gCg	p.V254A	EML1_ENST00000334192.4_Missense_Mutation_p.V273A|EML1_ENST00000327921.9_Missense_Mutation_p.V242A	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	254						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GCATCCGTGGTGGTGTTATAC	0.527000													33	72					0	0	1	0	0
RDM1	201299	broad.mit.edu	37	17	34249575	34249575	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:34249575T>C	ENST00000430160.2	-	4	1074	c.604A>G	c.(604-606)Act>Gct	p.T202A	RDM1_ENST00000293273.6_Intron|RDM1_ENST00000591402.1_Intron|RDM1_ENST00000431884.2_Intron|RDM1_ENST00000425909.3_Intron|RDM1_ENST00000419453.2_Intron|RDM1_ENST00000394527.1_3'UTR|RDM1_ENST00000394528.3_Missense_Mutation_p.T225A|RDM1_ENST00000394529.3_Intron			Q8NG50	RDM1_HUMAN	RAD52 motif 1	0					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATCAAGACAGTCTTACCTAGA	0.328000								Other identified genes with known or suspected DNA repair function					28	127					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136379096	136379096	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:136379096T>C	ENST00000264160.4	+	6	706	c.336T>C	c.(334-336)ttT>ttC	p.F112F	R3HDM1_ENST00000409606.1_Silent_p.F112F|R3HDM1_ENST00000410054.1_Silent_p.F56F|R3HDM1_ENST00000409478.1_Silent_p.F68F|R3HDM1_ENST00000329971.3_Silent_p.F68F	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	112							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		CACAATCATTTGAGAAAGAAG	0.328000													3	21					0	0	1	0	0
OGFOD1	55239	broad.mit.edu	37	16	56500103	56500103	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:56500103G>A	ENST00000566157.1	+	5	611	c.488G>A	c.(487-489)cGg>cAg	p.R163Q	OGFOD1_ENST00000568397.1_Missense_Mutation_p.R163Q	NM_018233.3	NP_060703.3	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain containing 1	163	Fe2OG dioxygenase.						iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8					Vitamin C(DB00126)	GAAGGGCGCCGGATTGCCTTC	0.522000													6	73					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27844717	27844717	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27844717G>T	ENST00000318304.8	+	27	3022	c.2739G>T	c.(2737-2739)ttG>ttT	p.L913F	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.L882F|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.L907F|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.L760F	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	913					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					TTGGGAATTTGAGAAAGAAGA	0.353000													25	148					4.22769e-11	4.39123e-11	1	1	0
PSMD1	5707	broad.mit.edu	37	2	231943377	231943377	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:231943377C>T	ENST00000308696.6	+	10	1238	c.1076C>T	c.(1075-1077)gCa>gTa	p.A359V	PSMD1_ENST00000409643.1_Missense_Mutation_p.A359V|PSMD1_ENST00000373635.4_Missense_Mutation_p.A359V	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	359					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	TTGCAGGATGCAGTACGGAAT	0.398000													10	23					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68867195	68867195	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:68867195T>C	ENST00000261769.5	+	16	2633	c.2442T>C	c.(2440-2442)aaT>aaC	p.N814N	CDH1_ENST00000422392.2_Silent_p.N753N|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	814	Required for binding alpha, beta and gamma catenins.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TTCTTTAGAATCTGAAAGCGG	0.488000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				4	80					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99149904	99149904	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99149904C>T	ENST00000074304.5	+	5	609	c.216C>T	c.(214-216)gtC>gtT	p.V72V	INPP4A_ENST00000409016.3_Silent_p.V72V|INPP4A_ENST00000409540.3_Silent_p.V72V|INPP4A_ENST00000545415.1_Silent_p.V72V|INPP4A_ENST00000523221.1_Silent_p.V72V|INPP4A_ENST00000409463.1_Silent_p.V72V|INPP4A_ENST00000409851.3_Silent_p.V72V	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	72	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						CGGTGAGTGTCACCACCCCTC	0.507000													30	105					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135038191	135038191	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:135038191C>T	ENST00000304613.3	+	30	5068	c.5047C>T	c.(5047-5049)Cac>Tac	p.H1683Y	KNDC1_ENST00000368572.2_Missense_Mutation_p.H1685Y			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1683	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GAGCCAGGTGCACGCGTTCCA	0.607000													10	51					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182347144	182347144	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:182347144A>G	ENST00000397033.2	+	8	1328	c.898A>G	c.(898-900)Aaa>Gaa	p.K300E		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	300					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AATGAAAGGTAAAAAGGTAAT	0.333000													21	87					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108496088	108496088	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:108496088C>T	ENST00000368986.4	+	3	928	c.220C>T	c.(220-222)Cgg>Tgg	p.R74W	NR2E1_ENST00000368983.3_Missense_Mutation_p.R111W	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	74					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		CAGGGCGTGTCGGCTGAAGAA	0.498000													23	37					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23549361	23549361	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23549361A>C	ENST00000262710.1	-	6	1684	c.1357T>G	c.(1357-1359)Tct>Gct	p.S453A	ACIN1_ENST00000555053.1_Missense_Mutation_p.S453A|ACIN1_ENST00000605057.1_Missense_Mutation_p.S395A|ACIN1_ENST00000457657.1_Missense_Mutation_p.S413A	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	453					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TTAGGAGGAGATAACTGAATG	0.502000													4	125					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202128645	202128645	+	Translation_Start_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:202128645C>T	ENST00000367279.4	-	1	474	c.3G>A	c.(1-3)atG>atA	p.M1I	PTPN7_ENST00000309017.3_Intron|PTPN7_ENST00000543735.1_Intron|PTPN7_ENST00000544762.1_Intron|PTPN7_ENST00000308986.5_Intron	NM_080588.2	NP_542155.1	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	0						cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						AGGAGGCTCCCATGCCAGGCC	0.587000													19	59					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101679591	101679591	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:101679591C>T	ENST00000261637.4	+	4	432	c.258C>T	c.(256-258)aaC>aaT	p.N86N		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	86					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ATCACCAAAACGAGATAGTTC	0.363000													27	106					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71069425	71069425	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:71069425C>T	ENST00000452400.2	-	11	1356	c.1175G>A	c.(1174-1176)gGg>gAg	p.G392E		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	392					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CAGTGGCTTCCCCATCGTTTG	0.433000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								12	48					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102305099	102305099	+	RNA	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:102305099C>G	ENST00000561463.1	+	0	13145																											ACCATCAGCACAGCTACGGGG	0.637000													7	24					0	0	1	0	0
ATAD2B	54454	broad.mit.edu	37	2	24021108	24021108	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:24021108A>G	ENST00000238789.5	-	19	2883	c.2540T>C	c.(2539-2541)gTg>gCg	p.V847A	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	847							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTTGCTCTCACAGTTTCACT	0.383000													10	22					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364596	30364596	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30364596C>T	ENST00000305596.3	-	6	996	c.821G>A	c.(820-822)cGg>cAg	p.R274Q	CD2BP2_ENST00000569466.1_Missense_Mutation_p.R274Q	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	274					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						ACCATCTCCCCGCGACTCTGC	0.572000													40	122					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101833102	101833102	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:101833102G>A	ENST00000360264.3	+	12	1080	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	CUX1_ENST00000556210.1_Missense_Mutation_p.E343K|CUX1_ENST00000549414.2_Missense_Mutation_p.E343K|CUX1_ENST00000437600.4_Missense_Mutation_p.E352K|CUX1_ENST00000550008.2_Missense_Mutation_p.E343K|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000425244.2_Missense_Mutation_p.E308K|CUX1_ENST00000546411.2_Missense_Mutation_p.E343K|CUX1_ENST00000393824.3_Missense_Mutation_p.E315K|CUX1_ENST00000547394.2_Missense_Mutation_p.E338K|CUX1_ENST00000292538.4_Missense_Mutation_p.E354K|CUX1_ENST00000292535.7_Missense_Mutation_p.E343K	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	343					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GCAACTGGAAGAAAAACTCAA	0.537000													12	40					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44611629	44611629	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:44611629G>A	ENST00000273320.3	+	6	1456	c.1027G>A	c.(1027-1029)Gat>Aat	p.D343N	RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000431636.1_Intron|ZKSCAN7_ENST00000426540.1_Missense_Mutation_p.D343N|ZKSCAN7_ENST00000341840.3_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		GGAAATAACAGATGAAGATAA	0.383000													44	102					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169173745	169173745	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:169173745T>C	ENST00000393743.3	-	27	3911	c.3620A>G	c.(3619-3621)cAt>cGt	p.H1207R	DDX60_ENST00000505393.1_5'UTR	NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1207							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TAGATTATCATGTTCAGCTTC	0.358000													60	179					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100514039	100514039	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:100514039A>G	ENST00000395996.1	+	26	4106	c.3995A>G	c.(3994-3996)aAa>aGa	p.K1332R	VPS13B_ENST00000358544.2_Missense_Mutation_p.K1332R|VPS13B_ENST00000357162.2_Missense_Mutation_p.K1332R			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1332					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTGCTTCCCAAAATTACTATA	0.453000													91	147					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26667099	26667099	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:26667099T>C	ENST00000288710.2	+	9	1112	c.1038T>C	c.(1036-1038)gaT>gaC	p.D346D	DRC1_ENST00000483675.1_3'UTR	NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		GCCTGCATGATATACTTAACA	0.413000													22	58					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138200106	138200106	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:138200106C>T	ENST00000237289.4	+	7	1590	c.1524C>T	c.(1522-1524)caC>caT	p.H508H		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	508	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.A506fs*21(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		ACGCCAGCCACGCCCCAGACC	0.562000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								23	55					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27327319	27327319	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:27327319T>A	ENST00000407991.1	-	3	861	c.253A>T	c.(253-255)Att>Ttt	p.I85F	CHRNA2_ENST00000520933.2_Missense_Mutation_p.I85F|CHRNA2_ENST00000240132.2_Intron	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	85						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AAGCGCACAATCACCACGTCT	0.627000													53	264					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228494170	228494170	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:228494170A>T	ENST00000570156.2	+	55	14702	c.14628A>T	c.(14626-14628)acA>acT	p.T4876T	OBSCN_ENST00000366707.4_Silent_p.T1553T|OBSCN_ENST00000284548.11_Silent_p.T3919T|OBSCN_ENST00000422127.1_Silent_p.T3919T|OBSCN_ENST00000366709.4_Silent_p.T1038T	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3919	IQ.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCACTGCTACAGTGGTCTGGA	0.672000													5	59					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23696242	23696242	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:23696242A>G	ENST00000546136.1	-	12	1637	c.1635T>C	c.(1633-1635)cgT>cgC	p.R545R	SOX5_ENST00000545921.1_Silent_p.R548R|SOX5_ENST00000396007.2_Silent_p.R172R|SOX5_ENST00000451604.2_Silent_p.R558R|SOX5_ENST00000537393.1_Silent_p.R523R|SOX5_ENST00000381381.2_Silent_p.R437R|SOX5_ENST00000309359.1_Silent_p.R545R|SOX5_ENST00000541536.1_Silent_p.R437R			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	558				E -> G (in Ref. 2; BAB85048).	transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						CATTCATTGGACGCTTTATGT	0.463000													7	165					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95470494	95470494	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:95470494A>G	ENST00000336148.5	-	3	429		c.e3+1		RAD54B_ENST00000297592.5_Splice_Site	NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)						double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			AAGCAGTCTTACCTGTATGAG	0.299000								Direct reversal of damage;Homologous recombination					25	129					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950891	235950891	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:235950891C>T	ENST00000409212.1	+	4	1985	c.1478C>T	c.(1477-1479)aCc>aTc	p.T493I	SH3BP4_ENST00000392011.2_Missense_Mutation_p.T493I|SH3BP4_ENST00000344528.4_Missense_Mutation_p.T493I			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	493					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		ACGGTAGTGACCATTTTTGGG	0.572000													27	71					0	0	1	0	0
CC2D2B	387707	broad.mit.edu	37	10	97779080	97779080	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:97779080T>C	ENST00000344386.3	+	7	807	c.643T>C	c.(643-645)Ttt>Ctt	p.F215L	ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|CC2D2B_ENST00000410012.2_Missense_Mutation_p.F215L|ENTPD1-AS1_ENST00000458228.1_RNA|ENTPD1-AS1_ENST00000454638.1_RNA|CC2D2B_ENST00000371198.2_Intron|RP11-690P14.4_ENST00000475252.2_Intron	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	215										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		AGATTGTTTGTTTGATGATAG	0.358000													21	49					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22920126	22920126	+	Nonsense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22920126C>G	ENST00000166244.3	+	7	1622	c.1550C>G	c.(1549-1551)tCa>tGa	p.S517*		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	517	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GCCCGCACCTCAGCAGGCTGT	0.697000													5	13					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84806196	84806196	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84806196T>C	ENST00000219473.7	+	12	2161	c.2048T>C	c.(2047-2049)gTg>gCg	p.V683A	USP10_ENST00000570191.1_Missense_Mutation_p.V687A	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	683					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						CCTGTCCTCGTGCTGCACCTG	0.443000													22	243					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64892912	64892912	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:64892912T>C	ENST00000555709.1	+	11	1514		c.e11+2		MTHFD1_ENST00000545908.1_Splice_Site|CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000555252.1_Splice_Site|MTHFD1_ENST00000216605.7_Splice_Site	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase						folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GGTGACTGGGTATGCTTTTTA	0.438000													13	100					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109196115	109196115	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:109196115C>A	ENST00000326495.5	-	11	1077	c.984G>T	c.(982-984)gaG>gaT	p.E328D	SSH1_ENST00000360239.3_Intron|SSH1_ENST00000326470.5_Missense_Mutation_p.E339D|SSH1_ENST00000551165.1_Missense_Mutation_p.E328D	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	328	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCTGCAGTTCCTCCAGATTGG	0.572000													24	33					1.85244e-09	1.91616e-09	1	1	0
ATP2A3	489	broad.mit.edu	37	17	3828691	3828691	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:3828691G>A	ENST00000352011.3	-	22	3167	c.3113C>T	c.(3112-3114)cCg>cTg	p.P1038L	ATP2A3_ENST00000397041.3_3'UTR|ATP2A3_ENST00000397039.1_Splice_Site_p.P212_splice|ATP2A3_ENST00000397035.3_3'UTR|ATP2A3_ENST00000359983.3_3'UTR|ATP2A3_ENST00000309890.7_3'UTR|ATP2A3_ENST00000397043.3_3'UTR			Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	1038					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGTACACACCGGAGACTCCAC	0.572000													6	30					0	0	1	0	0
SPCS1	28972	broad.mit.edu	37	3	52740853	52740853	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52740853G>A	ENST00000233025.7	+	3	752	c.342G>A	c.(340-342)tgG>tgA	p.W114*	SPCS1_ENST00000423431.1_Nonsense_Mutation_p.W25*|SPCS1_ENST00000602728.1_Nonsense_Mutation_p.W47*	NM_014041.3	NP_054760.3	Q9Y6A9	SPCS1_HUMAN	signal peptidase complex subunit 1 homolog (S. cerevisiae)	114					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to endoplasmic reticulum membrane|microsome|signal peptidase complex	peptidase activity			kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6				BRCA - Breast invasive adenocarcinoma(193;6.51e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)|OV - Ovarian serous cystadenocarcinoma(275;0.0469)		AGTTCGGGTGGACTGTCTATA	0.438000													52	200					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43474094	43474094	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43474094G>A	ENST00000532038.1	-	11	1483	c.1348C>T	c.(1348-1350)Cgc>Tgc	p.R450C	ARHGAP27_ENST00000428638.1_Missense_Mutation_p.R672C|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.R650C|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.R645C|ARHGAP27_ENST00000376922.2_Missense_Mutation_p.R331C|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.R304C|ARHGAP27_ENST00000455881.1_Missense_Mutation_p.R331C			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	672					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					AGGAACTTGCGGAGCTTGTGC	0.711000													7	48					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51879581	51879581	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:51879581T>C	ENST00000453097.2	+	17	2400	c.2183T>C	c.(2182-2184)aTg>aCg	p.M728T	SLC4A8_ENST00000358657.3_Missense_Mutation_p.M755T	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	728					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		GTACGCTCCATGGTGAGTGAC	0.398000													15	96					0	0	1	0	0
PROZ	8858	broad.mit.edu	37	13	113826404	113826404	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:113826404A>G	ENST00000342783.4	+	9	1261	c.1254A>G	c.(1252-1254)aaA>aaG	p.K418K	PROZ_ENST00000375547.2_Silent_p.K396K	NM_001256134.1	NP_001243063.1	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma glycoprotein	396					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity			NS(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(2)|skin(2)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	TCTGGTTTAAACAGATCATGA	0.547000													4	30					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017584	1017584	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1017584T>C	ENST00000421673.2	-	31	5267	c.5217A>G	c.(5215-5217)tcA>tcG	p.S1739S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1739	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGTGCTAAATGAGCTTCGGG	0.542000													116	799					0	0	1	0	0
SENP3-EIF4A1	100533955	broad.mit.edu	37	17	7476073	7476073	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7476073C>T	ENST00000579777.1	+	0	1984					NR_037926.1																						GGGGCCGGGGCGGCCAAACCA	0.627000													6	37					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55817973	55817973	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:55817973G>A	ENST00000313833.4	+	2	1110	c.865G>A	c.(865-867)Gag>Aag	p.E289K	FBXO34_ENST00000440021.1_Missense_Mutation_p.E289K	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	289										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						GTTGGAGTCTGAGTGCCTGAA	0.532000													47	193					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99705144	99705144	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99705144T>C	ENST00000344095.4	-	15	2284	c.1759A>G	c.(1759-1761)Acc>Gcc	p.T587A	TAF6_ENST00000453269.2_Missense_Mutation_p.T587A|AP4M1_ENST00000421755.1_Intron|TAF6_ENST00000452041.1_Missense_Mutation_p.T587A|TAF6_ENST00000472509.1_Missense_Mutation_p.T644A|TAF6_ENST00000437822.2_Missense_Mutation_p.T624A|TAF6_ENST00000418432.2_Missense_Mutation_p.T511A	NM_005641.3	NP_005632.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	587					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGGTGGCGGTGGAGACCAAC	0.662000													45	127					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76028487	76028487	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:76028487C>T	ENST00000319211.4	+	2	702	c.437C>T	c.(436-438)aCg>aTg	p.T146M		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	146					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	CACCTGGCCACGGCAGATGTG	0.498000													55	196					0	0	1	0	0
OGFOD1	55239	broad.mit.edu	37	16	56509460	56509460	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:56509460A>G	ENST00000566157.1	+	12	1573	c.1450A>G	c.(1450-1452)Aaa>Gaa	p.K484E	OGFOD1_ENST00000568397.1_Missense_Mutation_p.K441E	NM_018233.3	NP_060703.3	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain containing 1	484							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8					Vitamin C(DB00126)	TTACATTGCCAAAGGTGAAGA	0.368000													19	80					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794696	30794696	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30794696T>C	ENST00000262525.4	-	3	1160	c.953A>G	c.(952-954)tAc>tGc	p.Y318C		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			GGTGCAGCGGTATGGCTTCTC	0.627000													37	108					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43837051	43837051	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:43837051A>G	ENST00000372781.3	+	2	1170	c.1113A>G	c.(1111-1113)caA>caG	p.Q371Q	SEMG1_ENST00000244069.6_Silent_p.Q311Q	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ATGTATCCCAACGCAGTATTT	0.413000													24	78					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116767008	116767008	+	Translation_Start_Site	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:116767008G>T	ENST00000375288.1	-	0	687				SIK3_ENST00000542607.1_Missense_Mutation_p.L218M|SIK3_ENST00000375300.1_Missense_Mutation_p.L276M|SIK3_ENST00000446921.2_Missense_Mutation_p.L276M|SIK3_ENST00000292055.4_Missense_Mutation_p.L218M|SIK3_ENST00000434315.2_Missense_Mutation_p.L117M			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3							cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						TTTCCACTCAGCACGCGGGCC	0.517000													52	122					1.32667e-27	1.40583e-27	1	1	0
ARHGAP6	395	broad.mit.edu	37	X	11682447	11682447	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:11682447C>T	ENST00000337414.4	-	1	1374	c.502G>A	c.(502-504)Gct>Act	p.A168T	ARHGAP6_ENST00000380718.1_Missense_Mutation_p.A168T|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.A168T	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	168					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CTAGGAGAAGCGAAGATGCCA	0.647000													17	19					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104041313	104041313	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:104041313C>T	ENST00000265148.3	-	44	7410	c.7321G>A	c.(7321-7323)Gta>Ata	p.V2441I	CENPE_ENST00000380026.3_Missense_Mutation_p.V2320I	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2441	Kinetochore-binding domain.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ACCTGAAGTACTTGAATTGTC	0.313000													6	11					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066709	46066709	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:46066709C>A	ENST00000334670.8	+	1	379	c.334C>A	c.(334-336)Cct>Act	p.P112T	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	107	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						ctgctgcaagcctgtgtgctg	0.647000													20	252					3.86903e-22	4.0874e-22	1	1	0
RP11-125O5.2	0	broad.mit.edu	37	12	21207556	21207556	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:21207556C>T	ENST00000590779.1	+	1	29	c.29C>T	c.(28-30)cCg>cTg	p.P10L	LST3_ENST00000381541.3_Silent_p.S556S|SLCO1B7_ENST00000421593.2_Silent_p.S509S|SLCO1B7_ENST00000554957.1_Silent_p.S556S|LST3_ENST00000540229.1_Intron|SLCO1B3_ENST00000553473.1_Intron																							CCTCATATTCCGTGCTGGTGA	0.328000													16	28					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	532416	532416	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:532416T>C	ENST00000280886.6	-	2	227	c.140A>G	c.(139-141)tAc>tGc	p.Y47C	DIP2C_ENST00000381496.3_5'UTR	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	47						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTGCGGAAGGTAGGCTCCAAT	0.473000													31	92					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24771438	24771438	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:24771438G>A	ENST00000221166.5	+	1	914	c.132G>A	c.(130-132)tcG>tcA	p.S44S	GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000437366.2_Silent_p.S44S|NEFM_ENST00000518131.1_Silent_p.S44S			P07197	NFM_HUMAN	neurofilament, medium polypeptide	44	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CCCGCGGCTCGCCCAGCACCG	0.692000													28	75					0	0	1	0	0
RNF145	153830	broad.mit.edu	37	5	158603773	158603773	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:158603773A>G	ENST00000424310.2	-	5	847	c.488T>C	c.(487-489)gTt>gCt	p.V163A	RNF145_ENST00000518802.1_Missense_Mutation_p.V193A|RNF145_ENST00000519865.1_Missense_Mutation_p.V163A|RNF145_ENST00000520638.1_Missense_Mutation_p.V177A|RNF145_ENST00000274542.2_Missense_Mutation_p.V191A|RNF145_ENST00000521606.2_Missense_Mutation_p.V180A	NM_001199383.1	NP_001186312.1	Q96MT1	RN145_HUMAN	ring finger protein 145	163						integral to membrane	zinc ion binding			endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCCAAAGGAACAAGGCAGAG	0.388000													10	25					0	0	1	0	0
RIPK2	8767	broad.mit.edu	37	8	90802310	90802310	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:90802310G>A	ENST00000220751.4	+	11	1603	c.1289G>A	c.(1288-1290)cGt>cAt	p.R430H	RIPK2_ENST00000540020.1_Missense_Mutation_p.R293H	NM_003821.5	NP_003812.1	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	430					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	10			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TTTTCAGAACGTCTGCAGCCT	0.383000													30	50					0	0	1	0	0
NR2F6	2063	broad.mit.edu	37	19	17343360	17343360	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17343360A>G	ENST00000291442.3	-	4	1735	c.1016T>C	c.(1015-1017)gTg>gCg	p.V339A		NM_005234.3	NP_005225.2	P10588	NR2F6_HUMAN	nuclear receptor subfamily 2, group F, member 6	339	Important for dimerization (By similarity).|Ligand-binding (By similarity).				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						CTGCGCCCGCACATACTCGGT	0.697000													12	34					0	0	1	0	0
PREPL	9581	broad.mit.edu	37	2	44586917	44586917	+	Translation_Start_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:44586917T>C	ENST00000409936.1	-	0	375				PREPL_ENST00000410081.1_Intron|PREPL_ENST00000409411.1_Intron|PREPL_ENST00000409957.1_Intron|PREPL_ENST00000409272.1_Intron|PREPL_ENST00000540817.1_Intron|PREPL_ENST00000260648.6_De_novo_Start_OutOfFrame|PREPL_ENST00000541738.1_Intron	NM_001171606.1	NP_001165077.1	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like						proteolysis	cytosol	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(19)|ovary(1)|prostate(1)|skin(2)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATTTTATAGGTATGATTACAG	0.428000													5	25					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50864944	50864944	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50864944T>C	ENST00000253719.2	-	4	652	c.444A>G	c.(442-444)ggA>ggG	p.G148G	NR1H2_ENST00000600978.1_Intron|NR1H2_ENST00000542413.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	148					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		CGCTCAGGATTCCATCTACCC	0.512000													10	179					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64061862	64061862	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:64061862G>C	ENST00000324472.4	-	1	495	c.312C>G	c.(310-312)ttC>ttG	p.F104L	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	104					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTCTGCTGGAGAACCGCCGCG	0.592000													54	115					0	0	1	0	0
IRX5	10265	broad.mit.edu	37	16	54967744	54967744	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:54967744G>A	ENST00000394636.4	+	3	1748	c.1411G>A	c.(1411-1413)Gac>Aac	p.D471N	IRX5_ENST00000560154.1_Missense_Mutation_p.D251N|IRX5_ENST00000320990.5_Missense_Mutation_p.D470N|IRX5_ENST00000558597.1_Missense_Mutation_p.D405N			P78411	IRX5_HUMAN	iroquois homeobox 5	471					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						CCTGTGCAAAGACTCTCCCTA	0.468000													31	119					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70723272	70723272	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:70723272G>A	ENST00000229195.3	+	5	887	c.308G>A	c.(307-309)gGc>gAc	p.G103D	CNOT2_ENST00000418359.3_Missense_Mutation_p.G103D|CNOT2_ENST00000548230.1_3'UTR	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	103					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity	p.G103D(1)		cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			TTATCACAAGGCACTCAGTTA	0.458000													17	78					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46704755	46704755	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46704755C>T	ENST00000454366.1	+	4	889	c.677C>T	c.(676-678)gCg>gTg	p.A226V		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	207					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AGTCAGGCAGCGACTCAGAGG	0.632000													50	165					0	0	1	0	0
EGLN2	112398	broad.mit.edu	37	19	41312467	41312467	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41312467T>C	ENST00000593726.1	+	2	1879	c.851T>C	c.(850-852)gTg>gCg	p.V284A	EGLN2_ENST00000594140.1_Missense_Mutation_p.V2A|CTC-490E21.12_ENST00000601627.1_Intron|EGLN2_ENST00000406058.2_Missense_Mutation_p.V284A|EGLN2_ENST00000303961.4_Missense_Mutation_p.V284A|RAB4B-EGLN2_ENST00000594136.1_3'UTR			Q96KS0	EGLN2_HUMAN	egl-9 family hypoxia-inducible factor 2	284	Fe2OG dioxygenase.				cell redox homeostasis|estrogen receptor signaling pathway|positive regulation of protein catabolic process|regulation of cell growth|response to hypoxia	cytoplasm|nucleus	ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxygen sensor activity			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Vitamin C(DB00126)	CAGGCCATGGTGGCGTGTTAC	0.557000											OREG0025478	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	132					0	0	1	0	0
PRKAB1	5564	broad.mit.edu	37	12	120112203	120112203	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120112203A>G	ENST00000229328.5	+	4	968	c.476A>G	c.(475-477)gAc>gGc	p.D159G	PRKAB1_ENST00000541640.1_Missense_Mutation_p.D159G|PRKAB1_ENST00000540121.1_5'UTR	NM_006253.4	NP_006244.2	Q9Y478	AAKB1_HUMAN	protein kinase, AMP-activated, beta 1 non-catalytic subunit	159					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol				endometrium(2)|large_intestine(3)|lung(5)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	AAGAAAACTGACTTTGAAGTA	0.443000													21	96					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922448	17922448	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17922448C>T	ENST00000318683.6	+	3	783	c.636C>T	c.(634-636)gaC>gaT	p.D212D	B3GNT3_ENST00000595387.1_Silent_p.D212D	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	212					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GGGATGATGACGTCTTTGCAC	0.587000													19	56					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124820112	124820112	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124820112A>G	ENST00000356219.3	-	40	6358	c.6203T>C	c.(6202-6204)cTg>cCg	p.L2068P	NCOR2_ENST00000429285.2_Missense_Mutation_p.L2051P|NCOR2_ENST00000405201.1_Missense_Mutation_p.L2061P|NCOR2_ENST00000404121.2_Missense_Mutation_p.L1622P|NCOR2_ENST00000404621.1_Missense_Mutation_p.L2051P|NCOR2_ENST00000397355.1_Missense_Mutation_p.L2052P	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2072					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTCGTGGGTCAGACTGGGTGA	0.677000													15	51					0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130151298	130151298	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:130151298C>A	ENST00000373387.4	+	26	2995	c.2643C>A	c.(2641-2643)ccC>ccA	p.P881P	GARNL3_ENST00000496711.1_3'UTR|GARNL3_ENST00000314904.5_3'UTR|GARNL3_ENST00000435213.2_Silent_p.P859P	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	881					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						CACCCACTCCCATCAGTGTGG	0.527000													30	76					2.65835e-16	2.79074e-16	1	1	0
SCYL2	55681	broad.mit.edu	37	12	100709378	100709378	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:100709378T>C	ENST00000360820.2	+	9	1575	c.1138T>C	c.(1138-1140)Ttt>Ctt	p.F380L		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	380					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						GACTTCAGAATTTGTAAACCC	0.308000													28	120					0	0	1	0	0
ZNF791	163049	broad.mit.edu	37	19	12738816	12738816	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:12738816A>G	ENST00000343325.4	+	4	635	c.473A>G	c.(472-474)aAa>aGa	p.K158R	ZNF791_ENST00000458122.3_Missense_Mutation_p.K126R|ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000540038.1_Missense_Mutation_p.K49R|ZNF791_ENST00000446165.1_3'UTR	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						ACTGGAGAAAAACCCTATAAA	0.373000													12	83					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111155911	111155911	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:111155911G>C	ENST00000262839.2	-	3	1426	c.508C>G	c.(508-510)Cgg>Ggg	p.R170G		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	170					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGTGGGGCCGTGGGATAGTG	0.527000													3	69					0	0	1	0	0
GIPC1	10755	broad.mit.edu	37	19	14589555	14589555	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14589555G>T	ENST00000393033.4	-	8	1060	c.791C>A	c.(790-792)gCc>gAc	p.A264D	GIPC1_ENST00000586027.1_Missense_Mutation_p.A264D|GIPC1_ENST00000393028.1_Missense_Mutation_p.A167D|GIPC1_ENST00000345425.2_Missense_Mutation_p.A264D|GIPC1_ENST00000393029.3_Missense_Mutation_p.A167D|GIPC1_ENST00000591349.1_Missense_Mutation_p.A167D	NM_005716.3	NP_005707.1	O14908	GIPC1_HUMAN	GIPC PDZ domain containing family, member 1	264					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						CTTCTCAATGGCCTTCTCTTC	0.557000													91	227					6.07207e-39	6.43891e-39	1	1	0
MRPL2	51069	broad.mit.edu	37	6	43022195	43022195	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:43022195G>A	ENST00000230413.5	-	6	673	c.661C>T	c.(661-663)Ccg>Tcg	p.P221S	MRPL2_ENST00000489623.1_Missense_Mutation_p.P99S|MRPL2_ENST00000388752.3_Silent_p.G245G			Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2	0					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(2)	9		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		TGGATACTCGGCCTACTGTTG	0.547000													22	74					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67578197	67578197	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:67578197T>C	ENST00000310421.4	-	1	1255	c.997A>G	c.(997-999)Act>Gct	p.T333A		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	333	OTU.				protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TCTTTCCCAGTGCACTTCTCT	0.463000													34	144					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55592177	55592177	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55592177A>G	ENST00000201647.6	+	7	523	c.467A>G	c.(466-468)cAc>cGc	p.H156R	EPS8L1_ENST00000588359.1_Intron|EPS8L1_ENST00000245618.5_Missense_Mutation_p.H29R|EPS8L1_ENST00000586329.1_Missense_Mutation_p.H138R|EPS8L1_ENST00000540810.1_Missense_Mutation_p.H92R|EPS8L1_ENST00000592824.1_3'UTR	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	156						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GGGGCTCTGCACAATTACCGC	0.687000													10	28					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129291683	129291683	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:129291683A>G	ENST00000393239.1	-	14	3116		c.e14+1		PLXND1_ENST00000324093.4_Splice_Site			Q9Y4D7	PLXD1_HUMAN	plexin D1						axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GCCCCCCCTTACCACGTAGGA	0.687000													9	42					0	0	1	0	0
ARX	170302	broad.mit.edu	37	X	25033816	25033816	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:25033816C>T	ENST00000379044.4	-	1	249	c.39G>A	c.(37-39)agG>agA	p.R13R		NM_139058.2	NP_620689.1	Q96QS3	ARX_HUMAN	aristaless related homeobox	13						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(1)	4						TGCACTCGGGCCTCTCGGAGC	0.627000													3	3					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20645883	20645883	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:20645883C>T	ENST00000428453.1	-	0	2882																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GGTGTTGCTCCCTGTACACCA	0.537000													13	69					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18767277	18767277	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:18767277A>G	ENST00000406451.3	+	13	1947	c.1797A>G	c.(1795-1797)ggA>ggG	p.G599G	HDAC9_ENST00000441542.2_Silent_p.G602G|HDAC9_ENST00000432645.2_Silent_p.G599G|HDAC9_ENST00000401921.1_Silent_p.G558G	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	599					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GCATGGATGGATTAGAGAAAC	0.587000													6	32					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84205764	84205764	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:84205764G>A	ENST00000376499.3	-	16	2849	c.1785C>T	c.(1783-1785)gaC>gaT	p.D595D		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	595					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CGATGTTGCCGTCGCTGCAGC	0.607000													33	97					0	0	1	0	0
HOXC9	3225	broad.mit.edu	37	12	54394074	54394074	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:54394074T>C	ENST00000303450.4	+	1	172	c.102T>C	c.(100-102)caT>caC	p.H34H	HOXC9_ENST00000504557.1_Intron|HOXC9_ENST00000508190.1_Silent_p.H34H	NM_006897.1	NP_008828.1	P31274	HXC9_HUMAN	homeobox C9	34					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	14						CCGGGGCTCATCCCGCCGCCG	0.632000													19	109					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37871240	37871240	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:37871240G>T	ENST00000436120.2	+	4	329	c.222G>T	c.(220-222)atG>atT	p.M74I	ZNF527_ENST00000587349.1_Missense_Mutation_p.M74I|ZNF527_ENST00000483919.1_Missense_Mutation_p.M74I	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AACCGTGGATGGTGGAGAGAA	0.478000													10	45					3.86212e-05	3.93362e-05	1	1	0
CREB3L3	84699	broad.mit.edu	37	19	4171733	4171733	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:4171733C>T	ENST00000078445.2	+	10	1300	c.1153C>T	c.(1153-1155)Cga>Tga	p.R385*	CREB3L3_ENST00000602257.1_Nonsense_Mutation_p.R383*|CREB3L3_ENST00000252587.3_Silent_p.P273P|CREB3L3_ENST00000595923.1_Nonsense_Mutation_p.R384*|CREB3L3_ENST00000602147.1_3'UTR	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	385					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACCCCGACCCGAGGC	0.642000													49	157					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921350	12921350	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:12921350A>G	ENST00000240189.2	+	4	1228	c.1141A>G	c.(1141-1143)Acc>Gcc	p.T381A		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	381										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCTCACCACCTTCTACTT	0.577000													18	279					0	0	1	0	0
SOD3	6649	broad.mit.edu	37	4	24801537	24801537	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:24801537T>C	ENST00000382120.3	+	2	599	c.394T>C	c.(394-396)Tac>Cac	p.Y132H		NM_003102.2	NP_003093.2	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular	132					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding			prostate(1)|urinary_tract(1)	2		Breast(46;0.0503)				CGGGCCCCACTACAACCCGCT	0.736000													3	22					0	0	1	0	0
TTYH3	80727	broad.mit.edu	37	7	2687628	2687628	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:2687628T>C	ENST00000258796.7	+	5	867	c.662T>C	c.(661-663)gTc>gCc	p.V221A	TTYH3_ENST00000403167.1_Missense_Mutation_p.V50A|TTYH3_ENST00000477439.1_3'UTR|TTYH3_ENST00000407643.1_Intron	NM_025250.2	NP_079526.1	Q9C0H2	TTYH3_HUMAN	tweety family member 3	221						chloride channel complex|plasma membrane	chloride channel activity			kidney(1)|large_intestine(3)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	17		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CTGCTGGACGTCATCATCTGC	0.706000													21	90					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800372	27800372	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27800372C>T	ENST00000408964.2	+	1	984	c.933C>T	c.(931-933)ctC>ctT	p.L311L		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	311										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CCCCAAGGCTCTGTCCTCAAA	0.463000													33	96					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563444	140563444	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140563444T>A	ENST00000361016.2	+	1	2465	c.1310T>A	c.(1309-1311)aTa>aAa	p.I437K		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		437	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCACAACATAACAGTGCAG	0.512000													5	194					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418137	105418137	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:105418137G>A	ENST00000333244.5	-	7	3770	c.3651C>T	c.(3649-3651)tcC>tcT	p.S1217S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1217						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCAGGTCAGCGGAAGGGGGCT	0.647000													108	76					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1554577	1554577	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1554577C>A	ENST00000572621.1	-	41	6943	c.6678G>T	c.(6676-6678)acG>acT	p.T2226T	PRPF8_ENST00000304992.6_Silent_p.T2226T			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	2226	MPN.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GCTTGTAGGCCGTCAGTGTAC	0.617000													8	53					1	1	1	1	0
RNF4	6047	broad.mit.edu	37	4	2515440	2515440	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:2515440A>G	ENST00000511600.1	+	8	1982	c.467A>G	c.(466-468)cAt>cGt	p.H156R	RNF4_ENST00000541204.1_Missense_Mutation_p.H156R|RNF4_ENST00000506706.1_Missense_Mutation_p.H156R|RNF4_ENST00000511859.1_Missense_Mutation_p.M103V|RNF4_ENST00000314289.8_Missense_Mutation_p.H156R			P78317	RNF4_HUMAN	ring finger protein 4	156					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination|regulation of kinetochore assembly|regulation of spindle assembly|response to arsenic-containing substance	cytoplasm|PML body	androgen receptor binding|DNA binding|nucleosome binding|sequence-specific DNA binding transcription factor activity|SUMO polymer binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(2)|lung(1)	5		all_epithelial(65;0.241)				GAATGCGGCCATGTCTTCTGT	0.483000													36	104					0	0	1	0	0
SPRR3	6707	broad.mit.edu	37	1	152975621	152975621	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:152975621A>G	ENST00000331860.3	+	3	275	c.125A>G	c.(124-126)cAc>cGc	p.H42R	SPRR3_ENST00000295367.4_Missense_Mutation_p.H42R|SPRR3_ENST00000542696.1_Missense_Mutation_p.H42R	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	42					keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGCCATGCCACTCAAAGGTT	0.547000													8	58					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75658881	75658881	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:75658881C>A	ENST00000565683.1	-	4	415	c.404G>T	c.(403-405)gGg>gTg	p.G135V	MAN2C1_ENST00000267978.5_Missense_Mutation_p.G135V|MAN2C1_ENST00000563539.1_5'UTR|MAN2C1_ENST00000563622.1_Missense_Mutation_p.G135V|MAN2C1_ENST00000569482.1_Missense_Mutation_p.G135V	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	135					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						GTCTCTTTCCCCCAGCCTGTC	0.572000													6	28					3.59834e-05	3.66827e-05	1	1	0
TBC1D17	79735	broad.mit.edu	37	19	50384596	50384596	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50384596C>T	ENST00000221543.5	+	5	690	c.391C>T	c.(391-393)Cgc>Tgc	p.R131C	TBC1D17_ENST00000535102.2_Missense_Mutation_p.R98C|TBC1D17_ENST00000598789.1_3'UTR	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	131						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GTCCATCCGCCGCTCCAAGCC	0.682000													16	24					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45668930	45668930	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45668930C>T	ENST00000270172.3	-	11	1457	c.974G>A	c.(973-975)aGc>aAc	p.S325N	DNMT3L_ENST00000418993.1_Missense_Mutation_p.S325N	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	325					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TGGGATGTTGCTCCACACGCG	0.612000													5	19					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64537511	64537511	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64537511C>T	ENST00000377390.3	-	5	741	c.404G>A	c.(403-405)cGt>cAt	p.R135H	SF1_ENST00000422298.2_Missense_Mutation_p.R20H|SF1_ENST00000227503.9_Missense_Mutation_p.R135H|SF1_ENST00000377387.1_Missense_Mutation_p.R260H|SF1_ENST00000377394.3_Missense_Mutation_p.R135H|SF1_ENST00000433274.2_Missense_Mutation_p.R109H|SF1_ENST00000334944.5_Missense_Mutation_p.R135H	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	135					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						ATCACTCACACGTGTTGCTGG	0.463000													7	37					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238244938	238244938	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:238244938C>T	ENST00000295550.4	-	40	9257	c.8805G>A	c.(8803-8805)gcG>gcA	p.A2935A	COL6A3_ENST00000472056.1_Silent_p.A2328A|COL6A3_ENST00000353578.4_Silent_p.A2729A|COL6A3_ENST00000346358.4_Silent_p.A2735A|COL6A3_ENST00000409809.1_Silent_p.A2729A|COL6A3_ENST00000347401.3_Silent_p.A2734A	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2935	Ala-rich.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGGCTTCACCGCCACTGGGG	0.627000													42	133					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16547765	16547765	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16547765C>T	ENST00000597937.1	-	6	359	c.355G>A	c.(355-357)Gcc>Acc	p.A119T	EPS15L1_ENST00000594975.1_Missense_Mutation_p.A119T|EPS15L1_ENST00000535753.2_Missense_Mutation_p.A119T|EPS15L1_ENST00000455140.2_Missense_Mutation_p.A119T|EPS15L1_ENST00000248070.6_Missense_Mutation_p.A119T	NM_001258376.1	NP_001245305.1	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	119					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						GCCCAGTGGGCCTCTGCAGAG	0.502000													12	100					0	0	1	0	0
CLDN16	10686	broad.mit.edu	37	3	190106202	190106202	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:190106202T>C	ENST00000264734.2	+	1	542	c.294T>C	c.(292-294)tgT>tgC	p.C98C	CLDN16_ENST00000468220.1_Intron|CLDN16_ENST00000456423.1_Silent_p.C98C	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	98					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		GGACTGACTGTTGGATGGTGA	0.473000													74	241					0	0	1	0	0
FAM46A	55603	broad.mit.edu	37	6	82459576	82459576	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:82459576A>G	ENST00000369754.3	-	3	1534	c.1222T>C	c.(1222-1224)Tta>Cta	p.L408L	FAM46A_ENST00000369756.3_Silent_p.L470L|FAM46A_ENST00000320172.6_Silent_p.L389L			Q96IP4	FA46A_HUMAN	family with sequence similarity 46, member A	389										endometrium(2)|large_intestine(3)|lung(5)|skin(1)|urinary_tract(1)	12		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		TGGTCAGCTAACACCCGGATA	0.453000													38	82					0	0	1	0	0
ANKRD36BP1	84832	broad.mit.edu	37	1	168215989	168215989	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:168215989T>C	ENST00000358576.4	-	0	592					NR_026844.1															lung(1)	1						TTCTCCAGTTTAGAACGGAGC	0.403000													3	15					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634742	70634742	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:70634742A>G	ENST00000381269.2	-	2	1151	c.398T>C	c.(397-399)gTc>gCc	p.V133A	SLC8A3_ENST00000534137.1_Missense_Mutation_p.V133A|SLC8A3_ENST00000357887.3_Missense_Mutation_p.V133A|SLC8A3_ENST00000356921.2_Missense_Mutation_p.V133A|SLC8A3_ENST00000528359.1_Missense_Mutation_p.V133A	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	133					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CAGGTTGGAGACAGTTTCATT	0.483000													18	53					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	98943520	98943520	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:98943520T>C	ENST00000254898.5	+	3	713	c.482T>C	c.(481-483)gTg>gCg	p.V161A	MATN2_ENST00000524308.1_Missense_Mutation_p.V161A|MATN2_ENST00000521689.1_Missense_Mutation_p.V161A|MATN2_ENST00000522025.2_Intron|MATN2_ENST00000520016.1_Missense_Mutation_p.V161A	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	161	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			AGGGAGAATGTGCCACGGGTC	0.602000													4	64					0	0	1	0	0
FAM212B	55924	broad.mit.edu	37	1	112269753	112269753	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:112269753C>T	ENST00000357260.5	-	2	912	c.731G>A	c.(730-732)cGc>cAc	p.R244H	FAM212B_ENST00000444059.2_Missense_Mutation_p.R229H|FAM212B_ENST00000534365.1_Intron	NM_019099.4	NP_061972.1	Q9NTI7	CA183_HUMAN	family with sequence similarity 212, member B	244										cervix(1)|endometrium(1)	2						CTTCTGTGAGCGGCCGGTTCG	0.617000													35	119					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56471259	56471259	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:56471259T>C	ENST00000370754.5	-	39	8067	c.8068A>G	c.(8068-8070)Act>Gct	p.T2690A	DST_ENST00000370769.4_Missense_Mutation_p.T2512A|DST_ENST00000312431.6_Missense_Mutation_p.T2512A|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000446842.2_Missense_Mutation_p.T2186A|DST_ENST00000361203.3_Missense_Mutation_p.T2512A|DST_ENST00000244364.6_Intron			Q03001	DYST_HUMAN	dystonin	2512					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTGATCCAGTTTCCAGTGAC	0.378000													12	45					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714938	92714938	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:92714938C>T	ENST00000257068.2	+	2	555	c.549C>T	c.(547-549)taC>taT	p.Y183Y		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	183					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity	p.Y183Y(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CCCTGGAGTACGACCCACGCA	0.607000													15	58					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153744404	153744404	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:153744404C>T	ENST00000456435.1	+	26	3253	c.2067C>T	c.(2065-2067)ctC>ctT	p.L689L	INTS3_ENST00000476843.1_3'UTR|INTS3_ENST00000318967.2_Silent_p.L895L|INTS3_ENST00000435409.2_Silent_p.L895L|INTS3_ENST00000512605.1_Silent_p.L689L			Q68E01	INT3_HUMAN	integrator complex subunit 3	896					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGTCCCTGCTCATCAAGAACA	0.612000											OREG0013827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	37					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180832973	180832973	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:180832973A>G	ENST00000367590.4	+	12	1829	c.1631A>G	c.(1630-1632)aAc>aGc	p.N544S	XPR1_ENST00000367589.3_Missense_Mutation_p.N479S	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	544	EXS.					integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						GCTGGAGAGAACACTTTCCTC	0.398000													30	76					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022098	51022098	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:51022098G>A	ENST00000599957.1	-	3	1069	c.872C>T	c.(871-873)tCg>tTg	p.S291L	LRRC4B_ENST00000389201.3_Missense_Mutation_p.S291L			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	291						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GTGGGGCAGCGACATCAGGTT	0.637000													23	111					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131193775	131193775	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:131193775C>A	ENST00000541194.1	-	5	1299	c.1042G>T	c.(1042-1044)Gat>Tat	p.D348Y	PODXL_ENST00000378555.3_Missense_Mutation_p.D346Y|PODXL_ENST00000537928.1_Intron|PODXL_ENST00000322985.9_Missense_Mutation_p.D314Y	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	346					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					GTCTCAAGATCCTCACACTTT	0.507000													5	119					1.23904e-05	1.26627e-05	1	1	0
KIF6	221458	broad.mit.edu	37	6	39313554	39313554	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:39313554G>C	ENST00000287152.7	-	21	2337	c.2243C>G	c.(2242-2244)gCc>gGc	p.A748G	KIF6_ENST00000541946.1_Missense_Mutation_p.A199G|KIF6_ENST00000373216.3_Missense_Mutation_p.A731G|KIF6_ENST00000373213.4_Missense_Mutation_p.A587G|KIF6_ENST00000229913.5_Missense_Mutation_p.A199G|KIF6_ENST00000373215.3_Missense_Mutation_p.A731G|KIF6_ENST00000394362.1_Missense_Mutation_p.A182G|KIF6_ENST00000538893.1_Missense_Mutation_p.A692G	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	748					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GATTTTCCTGGCATTCACATC	0.473000													13	38					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47861552	47861552	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47861552A>T	ENST00000378460.2	-	4	637	c.591T>A	c.(589-591)gaT>gaA	p.D197E	NUP160_ENST00000530326.1_Missense_Mutation_p.D83E|NUP160_ENST00000532747.1_Intron|NUP160_ENST00000526870.1_3'UTR|NUP160_ENST00000528071.1_Missense_Mutation_p.D83E	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	197					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						AGTTGCAAGGATCTGTGAAAT	0.418000													12	107					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42457576	42457576	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:42457576A>G	ENST00000379310.3	-	9	1095	c.1027T>C	c.(1027-1029)Tat>Cat	p.Y343H	VWA8_ENST00000281496.6_Missense_Mutation_p.Y343H	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AAAATACTATATGGATAAAGC	0.373000													15	60					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201356220	201356220	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:201356220C>T	ENST00000391967.2	-	3	570	c.269G>A	c.(268-270)aGa>aAa	p.R90K	LAD1_ENST00000367313.3_Missense_Mutation_p.R104K	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	90						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CTGCCGTGTTCTGAGGATGCT	0.622000													19	31					0	0	1	0	0
CLDN11	5010	broad.mit.edu	37	3	170150423	170150423	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:170150423G>A	ENST00000064724.3	+	3	705	c.503G>A	c.(502-504)tGc>tAc	p.C168Y	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000489485.1_3'UTR|CLDN11_ENST00000486975.1_Intron	NM_005602.5	NP_005593.2	O75508	CLD11_HUMAN	claudin 11	168					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|liver(2)|lung(3)|ovary(2)	12	all_cancers(22;5.62e-23)|all_epithelial(15;7.54e-28)|all_lung(20;2.51e-17)|Lung NSC(18;1.02e-16)|Ovarian(172;0.000567)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GCTGTGCTGTGCCTCGTGGGT	0.587000													37	111					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28877396	28877396	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:28877396A>G	ENST00000282397.4	-	30	4176	c.3925T>C	c.(3925-3927)Tac>Cac	p.Y1309H	FLT1_ENST00000540678.1_Missense_Mutation_p.Y527H|FLT1_ENST00000543394.1_Missense_Mutation_p.Y332H	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1309					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCGTGGTCGTAGGTGAACCTG	0.577000													11	98					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97272452	97272452	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:97272452T>A	ENST00000236228.6	+	11	1191	c.1109T>A	c.(1108-1110)aTt>aAt	p.I370N	PTBP2_ENST00000394184.3_Missense_Mutation_p.I386N|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000370198.1_Missense_Mutation_p.I375N|PTBP2_ENST00000426398.2_Missense_Mutation_p.I370N|PTBP2_ENST00000370197.1_Missense_Mutation_p.I375N|PTBP2_ENST00000541987.1_3'UTR	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	370	RRM 3.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CGTGTGAAGATTTTATACAAT	0.343000													16	59					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161507695	161507695	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:161507695T>G	ENST00000392142.4	+	9	2700	c.2552T>G	c.(2551-2553)gTc>gGc	p.V851G	MAP3K4_ENST00000348824.7_Missense_Mutation_p.V851G|MAP3K4_ENST00000366920.2_Missense_Mutation_p.V851G|MAP3K4_ENST00000366919.2_Missense_Mutation_p.V851G	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	851					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AAACAGTATGTCAAGGTAAGT	0.378000													3	46					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43003861	43003861	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:43003861T>C	ENST00000587309.1	-	15	2432	c.2409A>G	c.(2407-2409)tcA>tcG	p.S803S	KIF18B_ENST00000339151.4_Silent_p.S794S|KIF18B_ENST00000438933.2_Silent_p.S803S|KIF18B_ENST00000593135.1_Silent_p.S791S|KIF18B_ENST00000590129.1_Silent_p.S812S	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				CATGGGAGACTGAGGAACTGA	0.587000													3	12					0	0	1	0	0
STXBP6	29091	broad.mit.edu	37	14	25288463	25288463	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:25288463G>A	ENST00000548369.1	-	1	220	c.83C>T	c.(82-84)cCg>cTg	p.P28L	STXBP6_ENST00000358326.2_Intron|STXBP6_ENST00000396700.1_Intron|STXBP6_ENST00000550887.1_Intron|STXBP6_ENST00000419632.2_Intron|STXBP6_ENST00000323944.5_Intron|STXBP6_ENST00000546511.1_Intron|STXBP6_ENST00000548724.1_Intron			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	0					vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		ACCAGACTCCGGCAGGGTGAG	0.532000													17	42					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94245529	94245529	+	Silent	SNP	G	G	A	rs145840548	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:94245529G>A	ENST00000393140.1	-	3	324	c.222C>T	c.(220-222)tcC>tcT	p.S74S	PRIMA1_ENST00000316227.3_Silent_p.S74S|PRIMA1_ENST00000393143.1_Silent_p.S74S	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	74					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		TACCTggggcggagaggagtc	0.652000													7	20					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49439398	49439398	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49439398G>A	ENST00000221403.2	+	3	352	c.312G>A	c.(310-312)gcG>gcA	p.A104A	DHDH_ENST00000523250.1_Intron|DHDH_ENST00000522614.1_Silent_p.A104A	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	104					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		TGAACGCGGCGGAAGTTCGCG	0.642000													8	19					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887524	3887524	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:3887524C>T	ENST00000319331.3	+	2	1960	c.1199C>T	c.(1198-1200)gCc>gTc	p.A400V	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	400	LRRCT.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		ATGTTCTGTGCCATGCCGCCC	0.488000													29	101					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9347300	9347300	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:9347300G>A	ENST00000281419.3	+	1	407	c.67G>A	c.(67-69)Gcc>Acc	p.A23T	ASAP2_ENST00000315273.4_Missense_Mutation_p.A23T	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	23					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						GGCGCCCACGGCCTCCAGCTT	0.716000													14	32					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13701455	13701455	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:13701455G>A	ENST00000357447.2	-	21	2302	c.1934C>T	c.(1933-1935)gCg>gTg	p.A645V	FRMD4A_ENST00000378503.1_Missense_Mutation_p.A645V|FRMD4A_ENST00000358621.4_Missense_Mutation_p.A630V	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	645	Ser-rich.					cytoplasm|cytoskeleton	binding	p.A645V(1)		breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GCCGGCTTCCGCACAGCTTCC	0.657000													23	91					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95718778	95718778	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:95718778T>C	ENST00000524717.1	-	4	3656	c.2372A>G	c.(2371-2373)aAc>aGc	p.N791S		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	791					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CAAATGTCGGTTTATCTGATC	0.348000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								4	23					0	0	1	0	0
ACER3	55331	broad.mit.edu	37	11	76687369	76687369	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:76687369A>G	ENST00000532485.1	+	4	408	c.304A>G	c.(304-306)Ata>Gta	p.I102V	ACER3_ENST00000526597.1_Missense_Mutation_p.I7V|ACER3_ENST00000533873.1_Missense_Mutation_p.I65V|CTD-2547H18.1_ENST00000530190.1_RNA|ACER3_ENST00000538157.1_Missense_Mutation_p.I60V|ACER3_ENST00000530182.1_3'UTR	NM_018367.5	NP_060837.3	Q9NUN7	ACER3_HUMAN	alkaline ceramidase 3	102					ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)	9						CAGCTGTTGCATATTTGTGTA	0.279000													8	30					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130425	45130425	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:45130425T>G	ENST00000457685.2	-	6	2762	c.1439A>C	c.(1438-1440)gAg>gCg	p.E480A	ZNF334_ENST00000347606.4_Missense_Mutation_p.E518A|ZNF334_ENST00000593880.1_Missense_Mutation_p.E541A			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TTCACTACACTCATAAAGATT	0.403000													11	237					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33679526	33679526	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:33679526T>C	ENST00000394566.1	-	7	2827	c.2555A>G	c.(2554-2556)gAc>gGc	p.D852G	SLFN11_ENST00000308377.4_Missense_Mutation_p.D852G	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	852						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCGAACACTGTCCAACACAAT	0.478000													54	184					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80163993	80163993	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:80163993A>G	ENST00000281127.7	+	4	1501	c.622A>G	c.(622-624)Aac>Gac	p.N208D	NRXN3_ENST00000428277.2_Missense_Mutation_p.N238D|NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000335750.5_Missense_Mutation_p.N840D|NRXN3_ENST00000554719.1_Missense_Mutation_p.N840D|NRXN3_ENST00000557594.1_Missense_Mutation_p.N208D|RP11-242P2.1_ENST00000553322.1_RNA	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	208	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AACCATCTTCAACACTCAGGC	0.468000													8	81					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74704350	74704350	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:74704350C>A	ENST00000261918.4	-	11	1846	c.1298G>T	c.(1297-1299)aGg>aTg	p.R433M	SEMA7A_ENST00000543145.2_Missense_Mutation_p.R419M|SEMA7A_ENST00000542748.1_Missense_Mutation_p.R268M	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	433	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						GATAGTGCCCCTGTCTGTGTA	0.637000													13	73					4.36969e-10	4.52622e-10	1	1	0
MSANTD2	79684	broad.mit.edu	37	11	124637523	124637523	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:124637523T>C	ENST00000526629.1	-	3	1986	c.539A>G	c.(538-540)tAt>tGt	p.Y180C	MSANTD2_ENST00000374979.3_Missense_Mutation_p.Y410C|MSANTD2_ENST00000239614.4_Missense_Mutation_p.Y358C|MSANTD2_ENST00000524950.1_3'UTR			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	410																	AGGCAATAAATATTGAACAAC	0.473000													5	98					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010595	70010595	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:70010595A>G	ENST00000532298.1	-	7	682	c.683T>C	c.(682-684)tTg>tCg	p.L228S	PDXDC2P_ENST00000531894.1_RNA																breast(2)|endometrium(2)|kidney(6)|lung(2)|prostate(1)	13						CCAGTAGGGCAATCCTGAAGA	0.483000													15	66					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31501677	31501677	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:31501677T>C	ENST00000330498.3	+	14	1859	c.1840T>C	c.(1840-1842)Ttt>Ctt	p.F614L	C16orf58_ENST00000327237.2_3'UTR|C16orf58_ENST00000567994.1_3'UTR|C16orf58_ENST00000570164.1_3'UTR|SLC5A2_ENST00000564197.1_Intron	NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	614					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						CCTGCTCTGGTTTTGTGGAAT	0.652000													3	22					0	0	1	0	0
SLC29A1	2030	broad.mit.edu	37	6	44197128	44197128	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:44197128T>C	ENST00000393841.1	+	4	522	c.29_splice	c.e4-1	p.Y11_splice	SLC29A1_ENST00000371755.3_Splice_Site_p.Y11_splice|SLC29A1_ENST00000393844.1_Splice_Site_p.Y11_splice|SLC29A1_ENST00000371724.1_Splice_Site_p.Y11_splice|SLC29A1_ENST00000371740.5_Splice_Site_p.Y11_splice|SLC29A1_ENST00000371713.1_Splice_Site_p.Y11_splice|SLC29A1_ENST00000371731.1_Splice_Site_p.Y11_splice|SLC29A1_ENST00000371708.1_Splice_Site_p.Y11_splice|SLC29A1_ENST00000313248.7_Splice_Site_p.Y90_splice|SLC29A1_ENST00000427851.2_Splice_Site_p.Y11_splice	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	11					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	CCATTGCAGATACAAAGCTGT	0.557000													26	81					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855647	53855647	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53855647T>C	ENST00000458035.1	+	4	1836	c.1719T>C	c.(1717-1719)caT>caC	p.H573H	ZNF845_ENST00000595091.1_Silent_p.H573H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	573					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAGCAATCCATGGTATAGGGA	0.398000													18	66					0	0	1	0	0
CLDND1	56650	broad.mit.edu	37	3	98240028	98240028	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:98240028A>G	ENST00000503004.1	-	2	1120	c.241T>C	c.(241-243)Tgt>Cgt	p.C81R	CLDND1_ENST00000507874.1_Missense_Mutation_p.C81R|CLDND1_ENST00000510545.1_Missense_Mutation_p.C81R|CLDND1_ENST00000511081.1_Intron|CLDND1_ENST00000513287.1_Missense_Mutation_p.C81R|CLDND1_ENST00000394181.2_Missense_Mutation_p.C81R|CLDND1_ENST00000394185.2_Missense_Mutation_p.C81R|CLDND1_ENST00000394180.2_Missense_Mutation_p.C81R|CLDND1_ENST00000508503.1_5'UTR|CLDND1_ENST00000502288.1_Intron|CLDND1_ENST00000437922.1_Missense_Mutation_p.C104R|CLDND1_ENST00000341181.6_Missense_Mutation_p.C81R			Q9NY35	CLDN1_HUMAN	claudin domain containing 1	81						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	9						ATGGTGATACACCGTCTCCAC	0.383000													6	145					0	0	1	0	0
IFIT5	24138	broad.mit.edu	37	10	91178053	91178053	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:91178053G>A	ENST00000371795.4	+	2	1310	c.1097G>A	c.(1096-1098)cGt>cAt	p.R366H	IFIT5_ENST00000416601.1_Missense_Mutation_p.R318H	NM_012420.2	NP_036552.1	Q13325	IFIT5_HUMAN	interferon-induced protein with tetratricopeptide repeats 5	366							binding			endometrium(1)|large_intestine(4)|lung(4)	9						AAAGCTCTTCGTCTGGAGAAC	0.453000													24	81					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4398026	4398026	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:4398026A>G	ENST00000261254.3	+	4	859	c.590A>G	c.(589-591)tAc>tGc	p.Y197C		NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	197					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TTTGCCATGTACCCACCGTCG	0.542000			T	IGL@	"""NHL,CLL"""								50	201					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113348757	113348757	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:113348757A>T	ENST00000458497.1	+	9	1010	c.731A>T	c.(730-732)gAc>gTc	p.D244V	ALPK1_ENST00000504176.2_Missense_Mutation_p.D166V|ALPK1_ENST00000177648.9_Missense_Mutation_p.D244V	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	244							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ATACTGGCAGACATCTTTGTT	0.398000													19	46					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42232288	42232288	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:42232288A>G	ENST00000319977.4	+	7	1866	c.1629A>G	c.(1627-1629)tcA>tcG	p.S543S	C17orf53_ENST00000585683.1_Silent_p.S542S|C17orf53_ENST00000245382.6_Silent_p.S467S	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	543										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AGCCTGGCTCAGTGCTGCTGC	0.597000													8	30					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649387	75649387	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:75649387C>T	ENST00000361470.2	+	1	1342	c.1064C>T	c.(1063-1065)tCc>tTc	p.S355F		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	355	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CCAAGCACTTCCGTACTGCCA	0.692000													13	18					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711673	155711673	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:155711673G>A	ENST00000295101.2	+	3	1831	c.1354G>A	c.(1354-1356)Gta>Ata	p.V452I		NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	452					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	AGAAAAACTGGTATCTAAAAC	0.453000													24	69					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124053293	124053293	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:124053293G>A	ENST00000360013.3	+	9	1719	c.1592G>A	c.(1591-1593)cGg>cAg	p.R531Q	KALRN_ENST00000460856.1_Missense_Mutation_p.R531Q|KALRN_ENST00000240874.3_Missense_Mutation_p.R531Q	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	531					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CGCAAGGTGCGGCTCCACCAG	0.607000													20	68					0	0	1	0	0
VAPB	9217	broad.mit.edu	37	20	56993282	56993282	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:56993282T>C	ENST00000475243.1	+	2	412	c.74T>C	c.(73-75)gTt>gCt	p.V25A	VAPB_ENST00000265619.2_3'UTR|VAPB_ENST00000395802.3_Missense_Mutation_p.V25A	NM_004738.4	NP_004729.1	O95292	VAPB_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein B and C	25	MSP.				cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(2)|lung(3)|prostate(1)	6	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			TTCACCGATGTTGTCACCACC	0.463000													8	161					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48317939	48317939	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48317939T>C	ENST00000435803.1	+	18	7172	c.7148T>C	c.(7147-7149)aTa>aCa	p.I2383T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2383					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAAAATAATATAGACTTTTTC	0.348000													8	22					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98574264	98574264	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:98574264A>G	ENST00000359863.4	+	54	8306	c.8097A>G	c.(8095-8097)acA>acG	p.T2699T	TRRAP_ENST00000355540.3_Silent_p.T2681T|TRRAP_ENST00000446306.3_Silent_p.T2681T	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2699					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGGGAAGACACACAACCTCT	0.557000													7	100					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109839460	109839460	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109839460G>A	ENST00000357155.1	-	5	724	c.675C>T	c.(673-675)tgC>tgT	p.C225C	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	225	Fibronectin type-III.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CACTGAGTCCGCACTGGTTTT	0.552000													22	75					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74999222	74999222	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:74999222A>G	ENST00000261978.4	-	10	2280	c.1894T>C	c.(1894-1896)Tgc>Cgc	p.C632R	LTBP2_ENST00000556690.1_Missense_Mutation_p.C632R	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	632	EGF-like 3; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCGTCCTTGCACAGGCCCAGG	0.622000													12	38					0	0	1	0	0
NDUFAF6	137682	broad.mit.edu	37	8	96057819	96057819	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:96057819A>G	ENST00000396113.1	+	11	1298	c.248A>G	c.(247-249)gAa>gGa	p.E83G	NDUFAF6_ENST00000542894.1_Missense_Mutation_p.E123G|NDUFAF6_ENST00000396124.4_Missense_Mutation_p.E175G|NDUFAF6_ENST00000286687.4_Missense_Mutation_p.E23G|NDUFAF6_ENST00000396111.2_Missense_Mutation_p.E83G			Q330K2	CH038_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	175					biosynthetic process	mitochondrion	transferase activity										AAGGAACTGGAAAATTATGCT	0.289000													18	106					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1261492	1261492	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1261492T>C	ENST00000447027.1	+	30	3924	c.3866T>C	c.(3865-3867)aTc>aCc	p.I1289T	MUC5B_ENST00000529681.1_Missense_Mutation_p.I1286T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1286					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCTGCTTGATCGCCATCTGC	0.612000													7	61					0	0	1	0	0
TAZ	6901	broad.mit.edu	37	X	153648397	153648397	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153648397C>T	ENST00000299328.5	+	8	899	c.610C>T	c.(610-612)Cat>Tat	p.H204Y	TAZ_ENST00000350743.4_Missense_Mutation_p.H174Y|TAZ_ENST00000351413.4_Missense_Mutation_p.H190Y|TAZ_ENST00000369790.4_Missense_Mutation_p.H160Y|TAZ_ENST00000498029.1_3'UTR|TAZ_ENST00000369776.4_Missense_Mutation_p.H135Y	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin	204					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCTGAGTGTCATCTCAACCC	0.627000													6	146					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49671539	49671539	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:49671539T>C	ENST00000252826.5	+	5	597	c.471T>C	c.(469-471)ggT>ggC	p.G157G	TRPM4_ENST00000355712.5_Intron|TRPM4_ENST00000427978.2_Silent_p.G157G	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	157					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TCACTGGGGGTCTGCACACGG	0.607000													48	119					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39564395	39564395	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:39564395T>C	ENST00000265707.5	+	18	2034	c.1989T>C	c.(1987-1989)agT>agC	p.S663S	ADAM18_ENST00000523755.1_3'UTR|ADAM18_ENST00000379866.1_Silent_p.S639S|ADAM18_ENST00000541111.1_Silent_p.S77S	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	663					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CAGGGGGTAGTATTGATGATG	0.313000													9	51					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152939660	152939660	+	Translation_Start_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:152939660C>T	ENST00000393831.2	-	0	156				PNCK_ENST00000370142.1_Intron|PNCK_ENST00000447676.2_De_novo_Start_InFrame	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase							cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAACCCTGCACCACAGCTCTG	0.637000													12	17					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53302978	53302978	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53302978A>G	ENST00000438150.2	-	2	2854	c.1961T>C	c.(1960-1962)gTa>gCa	p.V654A	ZNF28_ENST00000457749.2_Missense_Mutation_p.V707A|ZNF28_ENST00000360272.4_Missense_Mutation_p.V654A|ZNF28_ENST00000414252.2_Missense_Mutation_p.V654A			P17035	ZNF28_HUMAN	zinc finger protein 28	707					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		ATGATGGTATACAAGGTTTGA	0.418000													47	131					0	0	1	0	0
PDHB	5162	broad.mit.edu	37	3	58419401	58419401	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:58419401A>G	ENST00000302746.6	-	2	95	c.53T>C	c.(52-54)cTg>cCg	p.L18P	PDHB_ENST00000485460.1_Missense_Mutation_p.L18P|PDHB_ENST00000474765.1_Intron	NM_000925.3|NM_001173468.1	NP_000916.2|NP_001166939.1	P11177	ODPB_HUMAN	pyruvate dehydrogenase (lipoamide) beta	18					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)	9				BRCA - Breast invasive adenocarcinoma(55;0.000179)|Kidney(10;0.00231)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.187)	NADH(DB00157)|Pyruvic acid(DB00119)	CCTCTTCAGCAGCCCGGAGAC	0.711000													3	19					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904329	73904329	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:73904329A>G	ENST00000342056.2	+	15	2446	c.2048A>G	c.(2047-2049)aAa>aGa	p.K683R	KCNQ5_ENST00000414165.2_Missense_Mutation_p.K554R|KCNQ5_ENST00000355194.4_Missense_Mutation_p.K664R|KCNQ5_ENST00000402622.2_Missense_Mutation_p.K674R|KCNQ5_ENST00000370398.1_Missense_Mutation_p.K664R|KCNQ5_ENST00000355635.3_Missense_Mutation_p.K665R|KCNQ5_ENST00000403813.2_Missense_Mutation_p.K655R	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	664					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GTGGATAGCAAAGATCTTTCG	0.493000													7	135					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115595055	115595055	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:115595055T>C	ENST00000361384.2	-	9	3896	c.2979A>G	c.(2977-2979)gaA>gaG	p.E993E	DCLRE1A_ENST00000369305.1_Silent_p.E993E	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	993					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		AGCTGCTGTGTTCACTGTAAG	0.353000								Other identified genes with known or suspected DNA repair function					17	49					0	0	1	0	0
C15orf57	90416	broad.mit.edu	37	15	40855200	40855200	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:40855200C>G	ENST00000358005.3	-	2	288	c.15G>C	c.(13-15)gaG>gaC	p.E5D	C15orf57_ENST00000560305.1_Missense_Mutation_p.E5D|C15orf57_ENST00000560109.1_5'UTR|C15orf57_ENST00000561011.1_Missense_Mutation_p.E5D|C15orf57_ENST00000559911.1_Missense_Mutation_p.E5D|C15orf57_ENST00000558871.1_Missense_Mutation_p.E5D|C15orf57_ENST00000558750.1_Missense_Mutation_p.E14D|C15orf57_ENST00000558113.1_Missense_Mutation_p.E5D|C15orf57_ENST00000416810.2_Missense_Mutation_p.E5D	NM_001080791.1|NM_052849.2	NP_001074260.1|NP_443081.1	Q9BV29	CO057_HUMAN	chromosome 15 open reading frame 57	5										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	9						AGTCAGCGCTCTCAAACATTT	0.443000													51	175					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72267523	72267523	+	RNA	SNP	G	G	A	rs138229913	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:72267523G>A	ENST00000438125.1	-	0	350							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										TGGAGCTCTCGAAGGGTTCTT	0.448000													4	82					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26534142	26534142	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:26534142G>A	ENST00000333478.6	-	8	2439	c.1857C>T	c.(1855-1857)tgC>tgT	p.C619C	GPR113_ENST00000541401.1_Silent_p.C421C|GPR113_ENST00000421160.2_Silent_p.C749C|GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000311519.1_Silent_p.C818C	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	818					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGGCCAGCAAGCAGAACACCA	0.612000													8	32					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35936545	35936545	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35936545G>A	ENST00000325722.3	-	6	1266	c.1032C>T	c.(1030-1032)taC>taT	p.Y344Y		NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	344	PKD 1.					cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCTGCCAGTCGTAGGTGTAGG	0.433000													30	94					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146807025	146807025	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:146807025A>G	ENST00000508784.1	-	4	1779	c.1552T>C	c.(1552-1554)Tcg>Ccg	p.S518P	ZNF827_ENST00000379448.4_Missense_Mutation_p.S518P|ZNF827_ENST00000513320.1_Missense_Mutation_p.S168P			Q17R98	ZN827_HUMAN	zinc finger protein 827	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					AGCAAAGGCGAGACGCCAGCC	0.587000													23	92					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238280912	238280912	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:238280912A>G	ENST00000295550.4	-	9	4200	c.3748T>C	c.(3748-3750)Tac>Cac	p.Y1250H	COL6A3_ENST00000472056.1_Missense_Mutation_p.Y643H|COL6A3_ENST00000353578.4_Missense_Mutation_p.Y1044H|COL6A3_ENST00000346358.4_Missense_Mutation_p.Y1050H|COL6A3_ENST00000392003.2_Missense_Mutation_p.Y843H|COL6A3_ENST00000392004.3_Missense_Mutation_p.Y1044H|COL6A3_ENST00000409809.1_Missense_Mutation_p.Y1044H|COL6A3_ENST00000347401.3_Missense_Mutation_p.Y1049H	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1250	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTGCGAACGTACTGGAACTCA	0.567000													5	88					0	0	1	0	0
ZBTB26	57684	broad.mit.edu	37	9	125681684	125681684	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:125681684T>C	ENST00000373656.3	-	2	603	c.530A>G	c.(529-531)gAc>gGc	p.D177G	ZBTB26_ENST00000373654.1_Missense_Mutation_p.D177G	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						AATATCACTGTCCTCCATATC	0.433000													27	89					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8807057	8807057	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:8807057T>A	ENST00000359478.2	-	6	380	c.193A>T	c.(193-195)Att>Ttt	p.I65F	MFAP5_ENST00000396549.2_Missense_Mutation_p.I65F|MFAP5_ENST00000538107.1_5'UTR|MFAP5_ENST00000540087.1_Missense_Mutation_p.I65F|MFAP5_ENST00000535336.1_Missense_Mutation_p.I65F|MFAP5_ENST00000433590.2_Intron|MFAP5_ENST00000543369.1_Missense_Mutation_p.I53F	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	65						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					GAAGGTGCAATATCAGCCAAA	0.493000													3	18					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36774272	36774272	+	Silent	SNP	A	A	G	rs148618747		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:36774272A>G	ENST00000280527.2	+	16	3259	c.2892A>G	c.(2890-2892)aaA>aaG	p.K964K	AC007401.2_ENST00000406220.1_Intron	NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	964					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				ATCAGAAGAAACAGTGGATAC	0.383000													21	69					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30639032	30639032	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30639032A>G	ENST00000376442.3	-	2	422	c.227T>C	c.(226-228)gTa>gCa	p.V76A		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	76					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						TGGCTTTTCTACCACTGCCTT	0.537000													108	306					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46795724	46795724	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46795724G>A	ENST00000262738.3	-	10	5301	c.5302C>T	c.(5302-5304)Cgg>Tgg	p.R1768W		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1768	Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCGGTCACCCGCAACCCGGAC	0.587000													18	75					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130265101	130265101	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:130265101T>C	ENST00000323301.4	+	25	2699	c.2095T>C	c.(2095-2097)Tgc>Cgc	p.C699R	LRSAM1_ENST00000300417.6_Missense_Mutation_p.C699R|LRSAM1_ENST00000373322.1_Missense_Mutation_p.C699R|LRSAM1_ENST00000483302.1_3'UTR|LRSAM1_ENST00000373324.4_Missense_Mutation_p.C672R	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	699					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						CTGCCAGCAGTGCTGCCAGCC	0.682000													3	21					0	0	1	0	0
C1orf198	84886	broad.mit.edu	37	1	230979560	230979560	+	Missense_Mutation	SNP	G	G	C	rs150666760	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:230979560G>C	ENST00000366663.5	-	3	607	c.467C>G	c.(466-468)tCc>tGc	p.S156C	C1orf198_ENST00000523410.1_Missense_Mutation_p.S26C|C1orf198_ENST00000470540.1_Missense_Mutation_p.S118C|C1orf198_ENST00000427697.2_5'UTR	NM_032800.2	NP_116189.1	Q9H425	CA198_HUMAN	chromosome 1 open reading frame 198	156										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	17	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GGAAGCTTTGGACAGTGGTCT	0.642000													10	287					0	0	1	0	0
TRIP4	9325	broad.mit.edu	37	15	64710846	64710846	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:64710846A>G	ENST00000261884.3	+	9	1337	c.1277A>G	c.(1276-1278)gAa>gGa	p.E426G		NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	426					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						CAGGATCAAGAATTTCAGGAA	0.468000													19	49					0	0	1	0	0
ZNF252P	286101	broad.mit.edu	37	8	146220894	146220894	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:146220894G>A	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						TCTTCTACCTGTGATGCTTCT	0.473000													5	54					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016236	38016236	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:38016236T>A	ENST00000261439.4	+	3	879	c.524T>A	c.(523-525)gTg>gAg	p.V175E	TBC1D1_ENST00000508802.1_Missense_Mutation_p.V175E	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	175						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						AAGTTCGAGGTGCTCTTCTGC	0.637000													52	177					0	0	1	0	0
KRTAP12-1	353332	broad.mit.edu	37	21	46101779	46101779	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:46101779G>T	ENST00000391617.1	-	1	299	c.260C>A	c.(259-261)cCc>cAc	p.P87H	TSPEAR_ENST00000323084.4_Intron	NM_181686.1	NP_859014.1	P59990	KR121_HUMAN	keratin associated protein 12-1	87	14 X 5 AA approximate repeats.					keratin filament				kidney(1)|large_intestine(1)|lung(1)|skin(2)	5						GCAGGAGATGGGTCTGCAGAG	0.642000													4	115					0.150653	0.150988	1	1	0
SEC16A	9919	broad.mit.edu	37	9	139371345	139371345	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:139371345C>T	ENST00000313050.7	-	1	796	c.723G>A	c.(721-723)gtG>gtA	p.V241V	SEC16A_ENST00000431893.2_Silent_p.V63V|SEC16A_ENST00000371706.3_Silent_p.V63V|SEC16A_ENST00000290037.6_Silent_p.V63V	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	63					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TGGCACAGGGCACCCCGCTGG	0.657000													12	28					0	0	1	0	0
LCOR	84458	broad.mit.edu	37	10	98715513	98715513	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98715513A>G	ENST00000540664.1	+	8	1679	c.1136A>G	c.(1135-1137)cAc>cGc	p.H379R	LCOR_ENST00000498444.1_Intron|LCOR_ENST00000371103.3_Missense_Mutation_p.H379R|LCOR_ENST00000356016.3_Missense_Mutation_p.H379R|LCOR_ENST00000371097.4_Missense_Mutation_p.H379R	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		GGGATTCCCCACAGTACACTG	0.428000													4	89					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138378335	138378335	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:138378335G>A	ENST00000356818.2	+	4	2528	c.1979G>A	c.(1978-1980)cGc>cAc	p.R660H	PPP1R26_ENST00000605660.1_Missense_Mutation_p.R660H|PPP1R26_ENST00000604351.1_Missense_Mutation_p.R660H|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Missense_Mutation_p.R660H|PPP1R26_ENST00000605286.1_Missense_Mutation_p.R660H	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	660						nucleolus	protein binding										GGCGACACTCGCATGTCACAG	0.642000													10	72					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123912683	123912683	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:123912683G>A	ENST00000373855.1	+	25	4145	c.3885G>A	c.(3883-3885)ggG>ggA	p.G1295G	CNTRL_ENST00000238341.5_Silent_p.G1295G|CNTRL_ENST00000373847.1_Silent_p.G743G|CNTRL_ENST00000373850.1_Silent_p.G743G			Q7Z7A1	CNTRL_HUMAN	centriolin	1295	Pro-rich.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						TGGTGTATGGGCCTCCACCCC	0.547000													28	78					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19651094	19651094	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19651094T>C	ENST00000586018.1	+	3	365	c.263T>C	c.(262-264)tTc>tCc	p.F88S	CILP2_ENST00000291495.4_Missense_Mutation_p.F82S			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	82						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GCCATCCGCTTCTACTACGGG	0.731000													6	19					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49400019	49400019	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49400019G>C	ENST00000418115.1	-	4	702	c.318C>G	c.(316-318)ttC>ttG	p.F106L	RHOA_ENST00000422781.1_Missense_Mutation_p.F106L|RHOA_ENST00000454011.2_Missense_Mutation_p.S66C	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	106					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding	p.F106L(1)		cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	CGTTGGGACAGAAATGCTTGA	0.443000													22	115					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37107713	37107713	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:37107713A>G	ENST00000421307.1	-	23	1989		c.e23+1		LRRFIP2_ENST00000396428.2_Intron|LRRFIP2_ENST00000336686.4_Splice_Site|LRRFIP2_ENST00000354379.4_Intron|LRRFIP2_ENST00000440230.1_Intron|LRRFIP2_ENST00000421276.2_Intron	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2						Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						ATGCTAACATACCTCTCCCGT	0.458000													39	109					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72997953	72997953	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:72997953C>T	ENST00000322038.5	+	2	1040	c.456C>T	c.(454-456)taC>taT	p.Y152Y	TSHZ1_ENST00000580243.1_Silent_p.Y197Y	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	197	Ser-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		gctccggGTACGACTGGCACC	0.662000													6	17					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10549118	10549118	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10549118C>G	ENST00000583535.1	-	12	1134	c.1047G>C	c.(1045-1047)ggG>ggC	p.G349G	MYH3_ENST00000226209.7_Silent_p.G349G	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	349	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GCTTGTAGAGCCCAGATTTCT	0.572000													19	70					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074457	106074457	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:106074457C>T	ENST00000278071.2	-	3	1805	c.1353G>A	c.(1351-1353)gcG>gcA	p.A451A	ITPRIP_ENST00000358187.2_Silent_p.A451A|ITPRIP_ENST00000337478.1_Silent_p.A451A	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	451						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						CCAGCTGCCCCGCCTTCCAGT	0.642000													5	103					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123984603	123984603	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:123984603C>T	ENST00000306315.5	-	4	1909	c.1474G>A	c.(1474-1476)Gcc>Acc	p.A492T	ZNF608_ENST00000504926.1_Missense_Mutation_p.A65T	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	492						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GAAGGGCTGGCTTTGATATCC	0.557000													28	95					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066456	168066456	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:168066456A>G	ENST00000367838.1	-	5	702	c.389T>C	c.(388-390)cTg>cCg	p.L130P	GPR161_ENST00000271357.5_Missense_Mutation_p.L130P|GPR161_ENST00000361697.2_Missense_Mutation_p.L130P|GPR161_ENST00000537209.1_Missense_Mutation_p.L150P|GPR161_ENST00000367836.1_5'UTR|GPR161_ENST00000546300.1_Missense_Mutation_p.L16P|GPR161_ENST00000367835.1_Missense_Mutation_p.L130P|GPR161_ENST00000539777.1_Missense_Mutation_p.L52P	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	130					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CATGGGGTACAGGACAGCATA	0.572000													29	83					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116931125	116931125	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:116931125G>A	ENST00000356083.3	+	3	1681	c.1290G>A	c.(1288-1290)ccG>ccA	p.P430P		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	430	Pro-rich.				cell adhesion		extracellular matrix structural constituent	p.P430P(1)		central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						AGAGGAACCCGGGAATGCCCA	0.617000													124	290					0	0	1	0	0
RPL31	6160	broad.mit.edu	37	2	101620626	101620626	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:101620626C>A	ENST00000409711.1	+	2	125	c.114C>A	c.(112-114)ttC>ttA	p.F38L	RPL31_ENST00000409650.1_Missense_Mutation_p.F38L|RPL31_ENST00000409038.1_Missense_Mutation_p.F38L|RPL31_ENST00000409320.3_Missense_Mutation_p.F38L|RPL31_ENST00000409000.1_Missense_Mutation_p.F38L|RPL31_ENST00000409028.4_Missense_Mutation_p.F38L|RPL31_ENST00000409733.1_Missense_Mutation_p.F38L|RPL31_ENST00000264258.3_Missense_Mutation_p.F38L			P62899	RL31_HUMAN	ribosomal protein L31	38					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(3)	8						GTAGGGGCTTCAAGAAGCGTG	0.448000													11	35					6.42651e-13	6.69979e-13	1	1	0
TSHZ1	10194	broad.mit.edu	37	18	72999677	72999677	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:72999677C>T	ENST00000322038.5	+	2	2764	c.2180C>T	c.(2179-2181)gCg>gTg	p.A727V	TSHZ1_ENST00000580243.1_Missense_Mutation_p.A772V	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	772						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		GACCCGCTGGCGATGCTGTAC	0.587000													5	41					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36597916	36597916	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:36597916C>A	ENST00000299440.5	+	2	3174	c.3062C>A	c.(3061-3063)cCt>cAt	p.P1021H		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	1021					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ACCATGAACCCTCAGGCAAGC	0.428000									Familial Hemophagocytic Lymphohistiocytosis				4	94					0.150653	0.150988	1	1	0
MPST	4357	broad.mit.edu	37	22	37420635	37420635	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:37420635C>A	ENST00000397225.2	+	2	1294	c.379C>A	c.(379-381)Ctg>Atg	p.L127M	MPST_ENST00000429360.2_Missense_Mutation_p.L127M|MPST_ENST00000401419.3_Missense_Mutation_p.L127M|MPST_ENST00000404802.3_Missense_Mutation_p.L127M|MPST_ENST00000341116.3_Missense_Mutation_p.L127M|MPST_ENST00000397129.1_Missense_Mutation_p.L147M|MPST_ENST00000404393.1_Missense_Mutation_p.L127M			P25325	THTM_HUMAN	mercaptopyruvate sulfurtransferase	127	Rhodanese 1.				cyanate catabolic process|response to toxin		3-mercaptopyruvate sulfurtransferase activity|thiosulfate sulfurtransferase activity			central_nervous_system(2)|kidney(1)|lung(2)|prostate(1)|skin(1)	7						CGCCGTGTCACTGCTTGATGG	0.701000													6	20					0.00198382	0.00200201	1	1	0
SLIT3	6586	broad.mit.edu	37	5	168244337	168244337	+	Missense_Mutation	SNP	G	G	A	rs148711550	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:168244337G>A	ENST00000519560.1	-	8	1180	c.761C>T	c.(760-762)gCg>gTg	p.A254V	SLIT3_ENST00000404867.3_Missense_Mutation_p.A254V|SLIT3_ENST00000332966.8_Missense_Mutation_p.A254V	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	254	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGCACATCCGCCACGTTGAA	0.592000													18	57					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616454	248616454	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248616454T>C	ENST00000342927.3	+	1	378	c.356T>C	c.(355-357)aTg>aCg	p.M119T		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGGGTCTCATGGCCTATGAC	0.547000													8	211					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10475301	10475301	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10475301G>A	ENST00000525621.1	-	9	1837	c.1356C>T	c.(1354-1356)caC>caT	p.H452H	TYK2_ENST00000524462.1_Silent_p.H267H|TYK2_ENST00000529370.1_Silent_p.H452H|TYK2_ENST00000264818.6_Silent_p.H452H	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	452	SH2; atypical.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCAGGGGTCCGTGGATCCCAT	0.667000													40	117					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128150963	128150963	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:128150963T>C	ENST00000368250.1	-	4	628	c.130A>G	c.(130-132)Ata>Gta	p.I44V	THEMIS_ENST00000368248.2_Missense_Mutation_p.I123V|THEMIS_ENST00000543064.1_Missense_Mutation_p.I123V|THEMIS_ENST00000537166.1_Missense_Mutation_p.I88V			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	123	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						TCTAGTTTTATATCCTTCTGA	0.408000													15	57					0	0	1	0	0
CRYAA	1409	broad.mit.edu	37	21	44589244	44589244	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:44589244G>A	ENST00000291554.2	+	1	127	c.35G>A	c.(34-36)cGc>cAc	p.R12H	CRYAA_ENST00000482775.1_3'UTR	NM_000394.2	NP_000385.1	P02489	CRYAA_HUMAN	crystallin, alpha A	12					anti-apoptosis|negative regulation of intracellular transport|protein homooligomerization|response to heat|visual perception	cytoplasm|nucleus	structural constituent of eye lens|unfolded protein binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						TGGTTCAAGCGCACCCTGGGG	0.632000													39	101					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915308	119915308	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:119915308C>T	ENST00000331113.4	+	1	1587	c.622C>T	c.(622-624)Ccg>Tcg	p.P208S		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	208					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GGAAACAGTGCCGTGCGGATC	0.552000													31	59					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	437625	437625	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:437625A>G	ENST00000338977.5	-	2	643	c.595T>C	c.(595-597)Tat>Cat	p.Y199H	ZNF721_ENST00000511833.2_Missense_Mutation_p.Y211H|ZNF721_ENST00000507078.1_Intron|ZNF721_ENST00000506646.1_Intron|ABCA11P_ENST00000451020.2_RNA					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						ATTTTCTTATATTCATTCAGG	0.373000													17	47					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	547673	547673	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:547673T>C	ENST00000239830.4	+	10	1173	c.994T>C	c.(994-996)Ttg>Ctg	p.L332L	CCDC77_ENST00000540180.1_Silent_p.L300L|CCDC77_ENST00000422000.1_Silent_p.L300L|CCDC77_ENST00000412006.2_Silent_p.L300L	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	332						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			TGGAAAAGTGTTGCCCGTTAT	0.348000													21	105					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100675253	100675253	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100675253A>G	ENST00000306151.4	+	3	620	c.556A>G	c.(556-558)Aca>Gca	p.T186A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	186	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TGATATGAGCACACCTCTGAC	0.428000													83	264					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45462020	45462020	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:45462020A>G	ENST00000303230.4	-	3	996	c.939T>C	c.(937-939)ggT>ggC	p.G313G		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	313						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ACTGAAGACAACCATCCCAGT	0.423000													12	26					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160968927	160968927	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:160968927G>A	ENST00000447678.1	-	33	5318	c.5198C>T	c.(5197-5199)gCa>gTa	p.A1733V	LPA_ENST00000316300.5_Missense_Mutation_p.A1733V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4241	Kringle 16.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AACAGTGGTTGCCTTCTTGCC	0.483000													21	125					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11001615	11001615	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:11001615C>T	ENST00000324288.8	+	11	2399	c.2266C>T	c.(2266-2268)Cgc>Tgc	p.R756C	CIITA_ENST00000537380.1_Intron|CIITA_ENST00000381835.5_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	756					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						GGGCGTGCCACGCTTTCTGGC	0.632000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								37	114					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951392	46951392	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:46951392T>C	ENST00000311124.4	-	3	1012	c.860A>G	c.(859-861)tAc>tGc	p.Y287C	SLC19A1_ENST00000567670.1_Missense_Mutation_p.Y287C|SLC19A1_ENST00000485649.2_Missense_Mutation_p.Y247C|SLC19A1_ENST00000380010.4_Missense_Mutation_p.Y287C	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	287					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GATGTGCACGTAGTAGACCAC	0.667000													18	161					0	0	1	0	0
KCNK12	56660	broad.mit.edu	37	2	47748557	47748557	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:47748557T>C	ENST00000327876.3	-	2	1389	c.782A>G	c.(781-783)gAc>gGc	p.D261G	MSH2_ENST00000461394.1_Intron	NM_022055.1	NP_071338.1	Q9HB15	KCNKC_HUMAN	potassium channel, subfamily K, member 12	261						integral to membrane	potassium channel activity|voltage-gated ion channel activity	p.0?(2)|p.?(2)		NS(1)|endometrium(1)|lung(3)|ovary(1)	6		all_hematologic(82;0.0495)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GCTCACCAGGTCCCCGAAGCC	0.632000													3	24					0	0	1	0	0
CPNE2	221184	broad.mit.edu	37	16	57153532	57153532	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:57153532G>A	ENST00000535318.2	+	8	1012	c.651G>A	c.(649-651)ctG>ctA	p.L217L	CPNE2_ENST00000537605.1_Silent_p.L115L|CPNE2_ENST00000290776.8_Silent_p.L217L|CPNE2_ENST00000565874.1_Silent_p.L217L			Q96FN4	CPNE2_HUMAN	copine II	217	C2 2.									central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				TGGTGTCCCTGTGTGATGGGG	0.627000													3	26					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88910239	88910239	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:88910239T>C	ENST00000347404.5	-	5	964	c.392A>G	c.(391-393)gAa>gGa	p.E131G	KITLG_ENST00000228280.5_Missense_Mutation_p.E131G|KITLG_ENST00000357116.4_Intron|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	131					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						GAGCCTGGGTTCTGGGCTCTT	0.343000									Testicular Cancer, Familial Clustering of				19	55					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448713	89448713	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:89448713T>C	ENST00000399794.2	-	3	1512	c.797A>G	c.(796-798)tAt>tGt	p.Y266C	CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000260508.4_Intron|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000446900.2_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.Y266C	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	266							nucleotide binding|RNA binding										ATCACGACCATATCCATCTCT	0.448000													22	241					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111965594	111965594	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:111965594A>G	ENST00000369732.3	-	6	618	c.563T>C	c.(562-564)gTc>gCc	p.V188A	OVGP1_ENST00000540696.1_Missense_Mutation_p.V128A|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	188					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		GATGTGTGGGACCCCAGAAAC	0.542000													24	334					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45295429	45295429	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:45295429C>G	ENST00000447098.2	-	8	951	c.940G>C	c.(940-942)Gag>Cag	p.E314Q	PTCH2_ENST00000372192.3_Missense_Mutation_p.E314Q	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	314					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					TGCAGGGCCTCTGCCCTGGTG	0.592000									Basal Cell Nevus syndrome				16	47					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55846878	55846878	+	Silent	SNP	A	A	G	rs142672064	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:55846878A>G	ENST00000422046.2	-	9	1301	c.1020T>C	c.(1018-1020)aaT>aaC	p.N340N	CES1_ENST00000361503.4_Silent_p.N340N|CES1_ENST00000360526.3_Silent_p.N341N			P23141	EST1_HUMAN	carboxylesterase 1	340					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CAGTGTGGAAATTCCTTTCAG	0.512000													36	79					0	0	1	0	0
CNKSR3	154043	broad.mit.edu	37	6	154763422	154763422	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:154763422A>G	ENST00000607772.1	-	3	763	c.219T>C	c.(217-219)aaT>aaC	p.N73N	CNKSR3_ENST00000479339.1_5'UTR	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	73					negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CGAGGCCATAATTCTGTGGAA	0.423000													33	85					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163057115	163057115	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:163057115T>C	ENST00000188790.4	-	15	1445	c.1238A>G	c.(1237-1239)aAt>aGt	p.N413S	FAP_ENST00000443424.1_Missense_Mutation_p.N388S	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	413					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TTCAAATTCATTGCTAGAATA	0.234000													9	18					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11022950	11022950	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11022950A>G	ENST00000327064.4	+	5	839	c.649A>G	c.(649-651)Acc>Gcc	p.T217A	CARM1_ENST00000344150.4_Missense_Mutation_p.T217A	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	217					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						GGAGGCCAGCACCATGGCCCA	0.632000													7	275					0	0	1	0	0
COPS4	51138	broad.mit.edu	37	4	83978433	83978433	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:83978433A>T	ENST00000509093.1	+	6	1365	c.587A>T	c.(586-588)gAt>gTt	p.D196V	COPS4_ENST00000503682.1_Missense_Mutation_p.D196V|COPS4_ENST00000264389.2_Missense_Mutation_p.D196V|COPS4_ENST00000511653.1_Missense_Mutation_p.D196V	NM_001258006.1	NP_001244935.1	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	196					cullin deneddylation	cytoplasm|signalosome	protein binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|urinary_tract(2)	13		Hepatocellular(203;0.114)				CGTGTTCTTGATTATAGAAGA	0.348000													6	73					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95799391	95799391	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:95799391A>G	ENST00000416240.2	-	13	1470	c.1280T>C	c.(1279-1281)gTc>gCc	p.V427A	SLC25A13_ENST00000542654.1_Missense_Mutation_p.V318A|SLC25A13_ENST00000265631.5_Missense_Mutation_p.V426A	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	426					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TGCAAGTGGGACCGAACCATC	0.353000													35	139					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2813199	2813199	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:2813199G>A	ENST00000520002.1	-	65	10464	c.9909C>T	c.(9907-9909)tgC>tgT	p.C3303C	CSMD1_ENST00000602557.1_Silent_p.C3303C|CSMD1_ENST00000602723.1_Silent_p.C3126C|CSMD1_ENST00000542608.1_Silent_p.C3125C|CSMD1_ENST00000537824.1_Silent_p.C3302C|CSMD1_ENST00000400186.3_Silent_p.C3126C			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3303	Sushi 28.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGCCTGGATGGCAGGTGTACA	0.502000													53	113					0	0	1	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512579	68512579	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:68512579G>A	ENST00000370981.1	-	4	1038	c.402C>T	c.(400-402)atC>atT	p.I134I	GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000420587.1_RNA|DIRAS3_ENST00000395201.1_Silent_p.I134I			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	134					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGATCTTGCAGATCAGCTCAT	0.547000													45	192					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	40012818	40012818	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:40012818A>G	ENST00000308666.3	-	1	735	c.600T>C	c.(598-600)gaT>gaC	p.D200D		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	200	ABC transmembrane type-1.|Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						CCAGCCTCCCATCCATATTGA	0.413000													18	138					0	0	1	0	0
ASF1B	55723	broad.mit.edu	37	19	14231467	14231467	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14231467T>C	ENST00000263382.3	-	4	912	c.413A>G	c.(412-414)aAc>aGc	p.N138S	ASF1B_ENST00000592798.1_Missense_Mutation_p.N79S	NM_018154.2	NP_060624.1	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B histone chaperone	138	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus				endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7						GGCCAAGATGTTCCGCTGGAG	0.607000													6	49					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122928453	122928453	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:122928453C>G	ENST00000534624.1	-	9	2206	c.1930G>C	c.(1930-1932)Gag>Cag	p.E644Q	HSPA8_ENST00000453788.2_Missense_Mutation_p.E491Q|HSPA8_ENST00000227378.3_Missense_Mutation_p.E644Q|HSPA8_ENST00000526110.1_Missense_Mutation_p.E625Q|HSPA8_ENST00000534319.1_Missense_Mutation_p.E408Q|HSPA8_ENST00000533540.1_Missense_Mutation_p.E498Q|HSPA8_ENST00000532636.1_Missense_Mutation_p.E644Q	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	644					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TAATCAACCTCTTCAATGGTG	0.483000													21	88					0	0	1	0	0
FZD9	8326	broad.mit.edu	37	7	72849113	72849113	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:72849113G>A	ENST00000344575.3	+	1	1005	c.776G>A	c.(775-777)cGc>cAc	p.R259H		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	259					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				GAGCCCCACCGCTTCCAGTAC	0.637000													5	234					0	0	1	0	0
CNPY4	245812	broad.mit.edu	37	7	99722182	99722182	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99722182T>C	ENST00000262932.3	+	5	643	c.511T>C	c.(511-513)Tac>Cac	p.Y171H	CNPY4_ENST00000480692.1_3'UTR|RP11-506M12.1_ENST00000494221.1_RNA	NM_152755.1	NP_689968.1	Q8N129	CNPY4_HUMAN	canopy FGF signaling regulator 4	171	Glu-rich.					extracellular region				breast(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGAGACTGGTACTTCCACCA	0.507000													27	77					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6380415	6380415	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:6380415G>A	ENST00000394456.5	-	13	1895	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F	GTF2F1_ENST00000429701.2_Silent_p.F392F	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	477					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						TCTTGGTCTGGAACTTTTTCA	0.577000													5	260					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83810446	83810446	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:83810446A>G	ENST00000349129.2	+	4	421	c.161A>G	c.(160-162)tAc>tGc	p.Y54C	DOPEY1_ENST00000237163.5_Missense_Mutation_p.Y54C|DOPEY1_ENST00000536812.1_Missense_Mutation_p.Y54C|DOPEY1_ENST00000369739.3_Missense_Mutation_p.Y54C	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	54					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AATGCAAAGTACCAAGTAGTA	0.358000													45	151					0	0	1	0	0
NT5DC3	51559	broad.mit.edu	37	12	104186974	104186974	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:104186974A>G	ENST00000392876.3	-	9	1027	c.987T>C	c.(985-987)gcT>gcC	p.A329A		NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	329							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						TTGGCTTCTCAGCCTGAACAA	0.428000													109	187					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241700726	241700726	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:241700726T>C	ENST00000498729.2	-	24	2431	c.2185A>G	c.(2185-2187)Acg>Gcg	p.T729A	KIF1A_ENST00000320389.7_Missense_Mutation_p.T720A	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	720					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CGCAGAGACGTGAACTGGTAC	0.612000													5	115					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86265261	86265261	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:86265261G>A	ENST00000394518.2	+	24	6387	c.6292G>A	c.(6292-6294)Ggc>Agc	p.G2098S	AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Missense_Mutation_p.G2102S|AKAP13_ENST00000394510.2_Missense_Mutation_p.G343S	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2098	DH.|Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GAAGACATATGGCAAGTTTTG	0.383000													6	100					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6636694	6636694	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:6636694C>T	ENST00000533371.1	-	9	1314	c.516G>A	c.(514-516)gtG>gtA	p.V172V	TPP1_ENST00000299427.6_Silent_p.V415V			O14773	TPP1_HUMAN	tripeptidyl peptidase I	415					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		GCCGTGGGAACACATTGCTGA	0.527000													16	50					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159188024	159188024	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:159188024G>A	ENST00000367075.3	-	14	1851	c.1683C>T	c.(1681-1683)ggC>ggT	p.G561G	EZR_ENST00000337147.7_Silent_p.G561G|EZR_ENST00000392177.4_Silent_p.G529G	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	561	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		ACTTGTCCCGGCCTTGCCTCA	0.582000			T	ROS1	NSCLC								59	142					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235966293	235966293	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:235966293A>G	ENST00000389794.3	-	8	3801	c.3627T>C	c.(3625-3627)tgT>tgC	p.C1209C	LYST_ENST00000536965.1_Silent_p.C1209C|LYST_ENST00000389793.2_Silent_p.C1209C			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1209					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TAAAACTACAACACTGAGAAT	0.373000													7	40					0	0	1	0	0
EGR2	1959	broad.mit.edu	37	10	64573155	64573155	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:64573155G>A	ENST00000242480.3	-	2	1568	c.1243C>T	c.(1243-1245)Cgc>Tgc	p.R415C	EGR2_ENST00000439032.1_Missense_Mutation_p.R415C|EGR2_ENST00000411732.1_Missense_Mutation_p.R365C	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	415					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					TTGGTGTGGCGCTTCCTCTCA	0.612000													23	124					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65342330	65342330	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:65342330C>T	ENST00000284037.5	+	18	2141	c.1752C>T	c.(1750-1752)aaC>aaT	p.N584N	ERBB2IP_ENST00000380936.1_Silent_p.N584N|ERBB2IP_ENST00000380939.2_Silent_p.N584N|ERBB2IP_ENST00000416865.2_Intron|ERBB2IP_ENST00000380938.2_Silent_p.N584N|ERBB2IP_ENST00000511297.1_Silent_p.N580N|ERBB2IP_ENST00000380943.2_Silent_p.N584N|ERBB2IP_ENST00000506030.1_Silent_p.N584N|ERBB2IP_ENST00000508515.1_Silent_p.N584N|ERBB2IP_ENST00000380935.1_Silent_p.N584N	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	584					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		CCTCTGAGAACTTGAAGCATA	0.333000													8	226					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643959	37643959	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:37643959T>C	ENST00000356958.4	-	5	1100	c.842A>G	c.(841-843)cAg>cGg	p.Q281R	ZNF585A_ENST00000355533.2_Missense_Mutation_p.Q226R|ZNF585A_ENST00000292841.5_Missense_Mutation_p.Q226R|ZNF585A_ENST00000392157.2_Missense_Mutation_p.Q226R|ZNF585A_ENST00000588723.1_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATGGGTCTTCTGGATGAAGGC	0.433000													6	229					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63548661	63548661	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:63548661T>C	ENST00000374852.3	-	12	1539	c.1472A>G	c.(1471-1473)tAc>tGc	p.Y491C	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	491	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						CTGAATGTTGTAGGGCACAGT	0.463000													20	21					0	0	1	0	0
GREM1	26585	broad.mit.edu	37	15	33023168	33023168	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:33023168T>C	ENST00000300177.4	+	2	466	c.277T>C	c.(277-279)Tgg>Cgg	p.W93R	GREM1_ENST00000322805.4_Missense_Mutation_p.W52R|GREM1_ENST00000560830.1_Missense_Mutation_p.W52R|GREM1_ENST00000560677.1_3'UTR	NM_001191322.1|NM_001191323.1|NM_013372.6	NP_001178251.1|NP_001178252.1|NP_037504.1	O60565	GREM1_HUMAN	gremlin 1, DAN family BMP antagonist	93					negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)	10		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		GAAGCGAGACTGGTGCAAAAC	0.607000													15	52					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47043455	47043455	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:47043455G>A	ENST00000450053.3	+	31	5007	c.4828G>A	c.(4828-4830)Gca>Aca	p.A1610T	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Missense_Mutation_p.A1426T	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1610							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GCTACAGACTGCAGTGCCAGC	0.622000													13	35					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400612	85400612	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:85400612G>A	ENST00000258888.5	+	6	3416	c.3249G>A	c.(3247-3249)gcG>gcA	p.A1083A		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1083					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCCAAAGGCGGGGCCGTGTA	0.617000													19	56					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78710237	78710237	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:78710237A>G	ENST00000436010.2	-	14	3143	c.2146T>C	c.(2146-2148)Ttt>Ctt	p.F716L	ROBO1_ENST00000467549.1_Missense_Mutation_p.F719L|ROBO1_ENST00000464233.1_Missense_Mutation_p.F755L|ROBO1_ENST00000495273.1_Missense_Mutation_p.F719L			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	755	Fibronectin type-III 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AATTCATTAAAAAAAGGGCGA	0.403000													11	26					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75078569	75078569	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75078569C>A	ENST00000261978.4	-	1	465	c.79G>T	c.(79-81)Gct>Tct	p.A27S	LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Missense_Mutation_p.A27S	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	27					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ACGAAGAGAGCCAGGGTGAGC	0.721000													7	23					8.12818e-05	8.26188e-05	1	1	0
UEVLD	55293	broad.mit.edu	37	11	18587996	18587996	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18587996T>C	ENST00000396197.3	-	5	419	c.391A>G	c.(391-393)Atg>Gtg	p.M131V	UEVLD_ENST00000540666.1_5'UTR|UEVLD_ENST00000541984.1_Intron|UEVLD_ENST00000543987.1_Missense_Mutation_p.M131V|UEVLD_ENST00000535484.1_Missense_Mutation_p.M93V|UEVLD_ENST00000320750.6_Missense_Mutation_p.M109V|UEVLD_ENST00000379387.4_Missense_Mutation_p.M109V|UEVLD_ENST00000300038.7_Missense_Mutation_p.M131V	NM_001040697.2|NM_001261384.1	NP_001035787.1|NP_001248313.1	Q8IX04	UEVLD_HUMAN	UEV and lactate/malate dehyrogenase domains	131	UEV.				cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						TTGGCAATCATTTCTTTAATT	0.353000													14	45					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877191	27877191	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:27877191G>A	ENST00000374011.2	-	6	2404	c.1436C>T	c.(1435-1437)gCc>gTc	p.A479V	AHDC1_ENST00000247087.5_Missense_Mutation_p.A479V|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	479							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGGGATCTTGGCCATCTTCAC	0.622000													9	27					0	0	1	0	0
EPDR1	54749	broad.mit.edu	37	7	37989894	37989894	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:37989894T>C	ENST00000199448.4	+	3	950	c.571T>C	c.(571-573)Ttt>Ctt	p.F191L	EPDR1_ENST00000559325.1_Missense_Mutation_p.F311L|EPDR1_ENST00000476620.1_Missense_Mutation_p.F89L|EPDR1_ENST00000425345.1_Missense_Mutation_p.F130L	NM_017549.4	NP_060019.2	Q9UM22	EPDR1_HUMAN	ependymin related 1	191					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						GTCTACGCGGTTTTTTGACAT	0.468000													9	36					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35870045	35870045	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35870045C>A	ENST00000377981.2	-	1	416	c.354G>T	c.(352-354)acG>acT	p.T118T		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GGTCATAGGCCGTGATGGCCA	0.617000													24	70					6.44725e-10	6.67513e-10	1	1	0
SCN9A	6335	broad.mit.edu	37	2	167055439	167055439	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:167055439G>A	ENST00000303354.6	-	27	6053	c.5713C>T	c.(5713-5715)Cgc>Tgc	p.R1905C	SCN9A_ENST00000409672.1_Missense_Mutation_p.R1893C|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1904C|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000375387.4_Missense_Mutation_p.R1905C			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1904	IQ.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCCTTAAGCGGTAACGTCTA	0.353000													30	135					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152419202	152419202	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:152419202A>G	ENST00000397345.3	-	120	19016	c.18814T>C	c.(18814-18816)Tat>Cat	p.Y6272H	NEB_ENST00000409198.1_Missense_Mutation_p.Y4571H|NEB_ENST00000172853.10_Missense_Mutation_p.Y4571H|NEB_ENST00000427231.2_Missense_Mutation_p.Y6272H|NEB_ENST00000603639.1_Missense_Mutation_p.Y6272H|NEB_ENST00000604864.1_Missense_Mutation_p.Y6272H	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6281					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGGTGGAAATAGTGTCGATAC	0.473000													8	22					0	0	1	0	0
SPOCK1	6695	broad.mit.edu	37	5	136324330	136324330	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:136324330A>G	ENST00000394945.1	-	8	878	c.709T>C	c.(709-711)Ttt>Ctt	p.F237L	SPOCK1_ENST00000282223.7_Missense_Mutation_p.F237L|SPOCK1_ENST00000509978.1_5'UTR	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	237					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTAGTGTCAAACCCTGCCAAA	0.532000													12	32					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207460793	207460793	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:207460793A>G	ENST00000264377.3	+	24	2594	c.2266A>G	c.(2266-2268)Acc>Gcc	p.T756A	ADAM23_ENST00000374416.1_Missense_Mutation_p.T756A|ADAM23_ENST00000374415.3_Missense_Mutation_p.T756A	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	756	EGF-like.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TAATGAAGCCACCTGCATTTG	0.453000													7	28					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5208367	5208367	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:5208367G>A	ENST00000372412.4	-	36	5759	c.5526C>T	c.(5524-5526)ttC>ttT	p.F1842F	PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Silent_p.F1394F|PTPRS_ENST00000588012.1_Silent_p.F1803F|PTPRS_ENST00000357368.4_Silent_p.F1841F|PTPRS_ENST00000587303.1_Silent_p.F1841F|PTPRS_ENST00000348075.2_Silent_p.F1803F|PTPRS_ENST00000262963.6_Silent_p.F1821F|PTPRS_ENST00000592099.1_Silent_p.F1394F			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1841	Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GCCAGTCTGTGAACTGGAACT	0.577000													6	28					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15740180	15740180	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:15740180A>G	ENST00000441682.2	+	0	1636							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						GCCTGCAGTGACCCACCCACC	0.582000													3	21					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559417	140559417	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140559417C>T	ENST00000239444.2	+	1	2047	c.1802C>T	c.(1801-1803)gCc>gTc	p.A601V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		601	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCCAGAACGCCTGGCTGTCG	0.721000													6	285					0	0	1	0	0
RHBDL2	54933	broad.mit.edu	37	1	39384785	39384785	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:39384785C>T	ENST00000289248.2	-	2	1108	c.100G>A	c.(100-102)Ggg>Agg	p.G34R	RHBDL2_ENST00000538156.1_Missense_Mutation_p.G101R|RHBDL2_ENST00000540558.1_Missense_Mutation_p.G34R|RP5-864K19.4_ENST00000433671.2_RNA|RHBDL2_ENST00000372985.3_Missense_Mutation_p.G114R|RHBDL2_ENST00000372990.1_Missense_Mutation_p.G34R			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)	34					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTACCTCCCCCATCCTCTCTC	0.473000													37	130					0	0	1	0	0
TLDC1	57707	broad.mit.edu	37	16	84529368	84529368	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84529368T>C	ENST00000343629.6	-	3	487	c.305A>G	c.(304-306)aAc>aGc	p.N102S	RP11-517C16.4_ENST00000568771.1_RNA|TLDC1_ENST00000561807.1_5'UTR|TLDC1_ENST00000535580.1_Missense_Mutation_p.N75S	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		CTCCTCGGAGTTTCCTTTCAA	0.547000													35	111					0	0	1	0	0
UPP1	7378	broad.mit.edu	37	7	48147071	48147071	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48147071T>C	ENST00000331803.4	+	9	1383	c.760T>C	c.(760-762)Ttt>Ctt	p.F254L	UPP1_ENST00000341253.4_Missense_Mutation_p.F254L|UPP1_ENST00000429491.2_Missense_Mutation_p.F117L|UPP1_ENST00000395564.4_Missense_Mutation_p.F254L|UPP1_ENST00000482015.1_3'UTR			Q16831	UPP1_HUMAN	uridine phosphorylase 1	254					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	18						GTCCTCGGTGTTTGCCGCCAT	0.637000													19	87					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124427915	124427915	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124427915G>A	ENST00000545135.1	-	1	3405	c.109C>T	c.(109-111)Cgg>Tgg	p.R37W	CCDC92_ENST00000544798.1_5'UTR|CCDC92_ENST00000545891.1_Missense_Mutation_p.R37W|CCDC92_ENST00000238156.3_Missense_Mutation_p.R54W			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	54										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		TGCTGCAGCCGCCTGATCTCG	0.657000													34	129					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100343222	100343222	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:100343222A>G	ENST00000294724.4	+	12	1927	c.1449A>G	c.(1447-1449)gaA>gaG	p.E483E	AGL_ENST00000361522.4_Silent_p.E466E|AGL_ENST00000361915.3_Silent_p.E483E|AGL_ENST00000361302.3_Silent_p.E467E|AGL_ENST00000370161.2_Silent_p.E467E|AGL_ENST00000370165.3_Silent_p.E483E|AGL_ENST00000370163.3_Silent_p.E483E	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	483					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAAGGAGAGAACTTATTTGCT	0.363000													15	48					0	0	1	0	0
SNX25	83891	broad.mit.edu	37	4	186185657	186185657	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:186185657G>A	ENST00000504273.1	+	4	599	c.305G>A	c.(304-306)aGa>aAa	p.R102K	SNX25_ENST00000264694.8_Missense_Mutation_p.R102K			Q9H3E2	SNX25_HUMAN	sorting nexin 25	102	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		GATGAAGTAAGATTTCTACAA	0.413000													6	98					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394269	164394269	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:164394269G>A	ENST00000280605.3	-	1	778	c.618C>T	c.(616-618)tgC>tgT	p.C206C		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	206						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AGGCTTCACAGCAATTCTGGT	0.507000													24	75					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100410812	100410812	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100410812T>G	ENST00000358173.3	-	11	2243	c.1775A>C	c.(1774-1776)gAc>gCc	p.D592A	EPHB4_ENST00000360620.3_Missense_Mutation_p.D592A	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	592					cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					AGTGAAGGGGTCGATGTAGAC	0.507000													9	65					0	0	1	0	0
TBX5	6910	broad.mit.edu	37	12	114841573	114841573	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:114841573G>A	ENST00000310346.4	-	2	797	c.131C>T	c.(130-132)gCc>gTc	p.A44V	TBX5_ENST00000552726.1_5'UTR|TBX5_ENST00000405440.2_Missense_Mutation_p.A44V|TBX5_ENST00000349716.5_Intron|TBX5_ENST00000526441.1_Missense_Mutation_p.A44V	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	44				GFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFT QQ -> ALAGAHLWSLTQKTCLRFEPRARSGPPASPPGRPR SRLHPA (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GGTGAAGGCGGCCTGCGGGGA	0.647000													28	125					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72440846	72440846	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:72440846G>C	ENST00000305425.4	-	1	484	c.62C>G	c.(61-63)tCc>tGc	p.S21C	DACH1_ENST00000354591.4_Missense_Mutation_p.S21C|DACH1_ENST00000359684.2_Missense_Mutation_p.S21C|DACH1_ENST00000313174.7_Missense_Mutation_p.S21C	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	21					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGCAGACGTGGAGATTGGGGG	0.632000													12	24					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112779062	112779062	+	Silent	SNP	C	C	T	rs149178674		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:112779062C>T	ENST00000295408.4	+	17	2510	c.2253C>T	c.(2251-2253)ggC>ggT	p.G751G	MERTK_ENST00000409780.1_Silent_p.G575G|MERTK_ENST00000421804.2_Silent_p.G751G			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	751	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.G751G(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TTTACAGTGGCGATTATTACC	0.478000													40	100					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36169867	36169867	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:36169867T>C	ENST00000335119.2	+	1	479	c.368T>C	c.(367-369)tTc>tCc	p.F123S		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	123	BTB.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TGTAACGACTTCCTTATTAAG	0.502000													8	120					0	0	1	0	0
GSK3A	2931	broad.mit.edu	37	19	42744142	42744142	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42744142C>T	ENST00000398249.4	-	1	1903	c.190G>A	c.(190-192)Gcc>Acc	p.A64T	GSK3A_ENST00000222330.3_Missense_Mutation_p.A146T|AC006486.9_ENST00000594664.1_Missense_Mutation_p.A59T			P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	146	Gly-rich.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity	p.A146T(1)		endometrium(3)|large_intestine(3)|lung(6)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	19		Prostate(69;0.00682)				TTCTTGATGGCGACTAGTTCC	0.572000													21	34					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5405138	5405138	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:5405138T>C	ENST00000262467.5	-	16	4697	c.4124A>G	c.(4123-4125)tAc>tGc	p.Y1375C		NM_001033053.2	NP_001028225.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	0	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TGGGCACTAGTATCTCCTGGC	0.557000													4	62					0	0	1	0	0
ZNF230	7773	broad.mit.edu	37	19	44513052	44513052	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:44513052G>A	ENST00000429154.2	+	3	354	c.126G>A	c.(124-126)acG>acA	p.T42T	ZNF230_ENST00000585632.1_Silent_p.T42T	NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				AGAACTTCACGAACCTGCTGT	0.517000													62	185					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183774697	183774697	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:183774697G>A	ENST00000318351.1	+	5	458	c.424G>A	c.(424-426)Gcc>Acc	p.A142T		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	142						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CGGTCTCACTGCCTATATCAG	0.493000													33	121					0	0	1	0	0
NTPCR	84284	broad.mit.edu	37	1	233113938	233113938	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:233113938G>A	ENST00000366628.4	+	5	621	c.534G>A	c.(532-534)ctG>ctA	p.L178L	NTPCR_ENST00000490098.1_3'UTR	NM_032324.1	NP_115700.1	Q9BSD7	NTPCR_HUMAN	nucleoside-triphosphatase, cancer-related	178							ATP binding|nucleoside-triphosphatase activity|nucleotide phosphatase activity|transferase activity			large_intestine(2)|lung(1)|ovary(1)	4						ACCACCTTCTGCCAGATATCG	0.517000													6	36					0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55790030	55790030	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:55790030C>T	ENST00000321149.3	-	3	518	c.151G>A	c.(151-153)Gca>Aca	p.A51T	DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000380679.1_Missense_Mutation_p.A51T|DYX1C1_ENST00000448430.2_Missense_Mutation_p.A51T|DYX1C1_ENST00000348518.3_Missense_Mutation_p.A51T|DYX1C1_ENST00000457155.2_Missense_Mutation_p.A51T	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	51	CS.|Mediates interaction with ESR1 and STUB1.				neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		TAAAGAAATGCCTCAAATAAA	0.393000													30	74					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49775950	49775950	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:49775950A>G	ENST00000492622.2	+	24	3307	c.3002A>G	c.(3001-3003)tAc>tGc	p.Y1001C	FNDC3A_ENST00000398316.3_Missense_Mutation_p.Y945C|FNDC3A_ENST00000541916.1_Missense_Mutation_p.Y1001C	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1001	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GTATCCCTATACAGAGGACCA	0.328000													4	40					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183909867	183909867	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:183909867A>T	ENST00000361927.4	-	11	1823	c.1452T>A	c.(1450-1452)aaT>aaA	p.N484K	COLGALT2_ENST00000367520.3_Missense_Mutation_p.N221K|COLGALT2_ENST00000546159.1_Missense_Mutation_p.N484K|COLGALT2_ENST00000367521.1_Missense_Mutation_p.N92K	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		GGTTTGCCACATTGGGCACTG	0.483000													28	80					0	0	1	0	0
EEPD1	80820	broad.mit.edu	37	7	36338672	36338672	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:36338672T>C	ENST00000242108.4	+	8	2285	c.1567T>C	c.(1567-1569)Tct>Cct	p.S523P	EEPD1_ENST00000534978.1_Missense_Mutation_p.S523P	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	523					DNA repair		DNA binding			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						GGATAACTGGTCTTGGGGCGG	0.592000													7	130					0	0	1	0	0
CRAT	1384	broad.mit.edu	37	9	131862173	131862173	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131862173T>C	ENST00000318080.2	-	8	1351	c.1057A>G	c.(1057-1059)Acc>Gcc	p.T353A	RP11-247A12.1_ENST00000434250.1_RNA	NM_000755.3|NM_001257363.1	NP_000746.2|NP_001244292.1	P43155	CACP_HUMAN	carnitine O-acetyltransferase	353					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	TCCAGAAGGGTGACAATAGGG	0.562000													4	120					0	0	1	0	0
ATP6V1E1	529	broad.mit.edu	37	22	18111367	18111367	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:18111367A>G	ENST00000253413.5	-	1	216		c.e1+1		ATP6V1E1_ENST00000399796.2_Splice_Site|ATP6V1E1_ENST00000478963.1_Splice_Site|ATP6V1E1_ENST00000399798.2_Splice_Site	NM_001696.3	NP_001687.1	P36543	VATE1_HUMAN	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1						cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|cytosol|endosome|proton-transporting two-sector ATPase complex, catalytic domain	protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|urinary_tract(1)	10		all_epithelial(15;0.206)		Lung(27;0.19)		CAAGCCCCTCACCTGCTTTTG	0.632000													49	266					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58461018	58461018	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:58461018C>T	ENST00000357552.3	-	26	2719	c.2492_splice	c.e26-1	p.G832_splice	SYCP2_ENST00000371001.2_Splice_Site_p.G832_splice			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	832					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TTTGAAAAACCACTGTAAAAA	0.269000													4	23					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765359	18765359	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:18765359C>T	ENST00000304081.4	-	5	986	c.886G>A	c.(886-888)Gtc>Atc	p.V296I	NT5C1B_ENST00000600945.1_Missense_Mutation_p.V356I|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.V356I|NT5C1B_ENST00000359846.2_Missense_Mutation_p.V356I	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AATACCTTGACGAAGCGGAAC	0.572000													30	107					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23240212	23240212	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:23240212A>G	ENST00000400191.3	+	17	3035	c.3017A>G	c.(3016-3018)gAc>gGc	p.D1006G	EPHB2_ENST00000374627.1_3'UTR|EPHB2_ENST00000374632.3_3'UTR|EPHB2_ENST00000374630.3_3'UTR	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	1006					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CAGCCACGAGACGTCACCAAG	0.562000													5	23					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133729579	133729579	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:133729579T>C	ENST00000318560.5	+	2	589	c.208T>C	c.(208-210)Tat>Cat	p.Y70H		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	70	SH3.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CGTTGCACTGTATGATTTTGT	0.478000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								62	164					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104831813	104831813	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:104831813T>A	ENST00000507740.1	+	1	314	c.78T>A	c.(76-78)aaT>aaA	p.N26K	RIMS2_ENST00000262231.10_Missense_Mutation_p.N26K|RIMS2_ENST00000522174.1_3'UTR|RIMS2_ENST00000406091.3_Intron	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1018	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCCCACCAAATATCTTACAAA	0.323000										HNSCC(12;0.0054)			8	70					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9364867	9364867	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:9364867G>A	ENST00000378501.2	+	11	888	c.873G>A	c.(871-873)ggG>ggA	p.G291G	PLCB4_ENST00000278655.4_Silent_p.G291G|PLCB4_ENST00000414679.2_Silent_p.G291G|PLCB4_ENST00000378493.1_Silent_p.G291G|PLCB4_ENST00000378473.3_Silent_p.G291G|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000334005.3_Silent_p.G291G	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	291					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CAAGTGATGGGTTTTGCAGAT	0.418000													23	86					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173961102	173961102	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:173961102C>A	ENST00000506823.1	+	13	2314	c.1657C>A	c.(1657-1659)Cct>Act	p.P553T	GALNTL6_ENST00000508122.1_Missense_Mutation_p.P536T	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	553	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						ATTATTCCATCCTGTGAGCAA	0.428000													15	60					1.45105e-14	1.51837e-14	1	1	0
IPO4	79711	broad.mit.edu	37	14	24650800	24650800	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24650800G>T	ENST00000354464.6	-	28	3140	c.2964C>A	c.(2962-2964)gcC>gcA	p.A988A	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	988					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		TCAGTGGCAGGGCATGCAGTA	0.622000													4	27					0.00024832	0.000251724	1	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274132	39274132	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39274132G>A	ENST00000391413.2	-	1	474	c.436C>T	c.(436-438)Cgc>Tgc	p.R146C		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	146	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			caagaggggcggcagcagctg	0.657000													12	54					0	0	1	0	0
EXOC6B	23233	broad.mit.edu	37	2	72740281	72740281	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:72740281C>T	ENST00000272427.6	-	11	1277	c.1147G>A	c.(1147-1149)Gca>Aca	p.A383T	EXOC6B_ENST00000410104.1_Missense_Mutation_p.A383T	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	383					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						CGGAGTGCTGCGATGGTTTTT	0.383000													15	32					0	0	1	0	0
PLAC8	51316	broad.mit.edu	37	4	84026117	84026117	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:84026117T>C	ENST00000426923.2	-	3	253	c.175A>G	c.(175-177)Aat>Gat	p.N59D	PLAC8_ENST00000311507.4_Missense_Mutation_p.N59D|PLAC8_ENST00000411416.2_Missense_Mutation_p.N59D|PLAC8_ENST00000505406.1_Missense_Mutation_p.N59D|PLAC8_ENST00000509973.1_Missense_Mutation_p.N2D|PLAC8_ENST00000515389.1_Intron	NM_001130715.1	NP_001124187.1	Q9NZF1	PLAC8_HUMAN	placenta-specific 8	59										large_intestine(2)|lung(3)|ovary(1)	6		Hepatocellular(203;0.114)				CAGCATTCATTCATATCAGCT	0.488000													38	67					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149949445	149949445	+	Translation_Start_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:149949445T>C	ENST00000369135.3	-	2	295	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	1					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TCCAGGGTCATGTGATCCTCA	0.468000													25	57					0	0	1	0	0
POLD3	10714	broad.mit.edu	37	11	74347277	74347277	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:74347277C>A	ENST00000263681.2	+	11	1284	c.1155C>A	c.(1153-1155)cgC>cgA	p.R385R	POLD3_ENST00000527458.1_Silent_p.R346R|POLD3_ENST00000532497.1_Silent_p.R279R	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	385					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					AACGAAAACGCGTACTAAAAT	0.368000													19	36					3.62473e-10	3.7563e-10	1	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110457059	110457059	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:110457059G>A	ENST00000378402.5	+	38	5065	c.4961G>A	c.(4960-4962)cGa>cAa	p.R1654Q		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1654					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTGATAGGCGATTTGTACTT	0.433000										HNSCC(38;0.096)			80	270					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97917855	97917855	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:97917855T>C	ENST00000534948.1	+	0	2633							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AGGTATTAGGTACCACCATTA	0.383000													16	43					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112097135	112097135	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112097135A>G	ENST00000419234.4	-	8	1180	c.987T>C	c.(985-987)tgT>tgC	p.C329C	BRAP_ENST00000539060.1_Silent_p.C150C|BRAP_ENST00000327551.6_Silent_p.C299C	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	329					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						CGCATATTAAACAAATCCAAA	0.463000													4	110					0	0	1	0	0
VLDLR	7436	broad.mit.edu	37	9	2648271	2648271	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:2648271T>C	ENST00000382100.2	+	13	2242	c.1886T>C	c.(1885-1887)tTg>tCg	p.L629S	VLDLR_ENST00000382099.2_Missense_Mutation_p.L629S	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor	629					cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		AGCGTGGACTTGAATGGCCAA	0.403000													4	120					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136905384	136905384	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:136905384G>C	ENST00000303407.7	-	9	1600	c.1415C>G	c.(1414-1416)gCc>gGc	p.A472G	BRD3_ENST00000371834.2_Missense_Mutation_p.A472G|BRD3_ENST00000357885.2_Missense_Mutation_p.A472G|BRD3_ENST00000473349.1_Intron	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	472						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		CTCGTGCACGGCCTTCAGCTG	0.617000			T	C15orf55	lethal midline carcinoma of young people								3	14					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3641708	3641708	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:3641708G>A	ENST00000335312.3	-	15	1870	c.1782C>T	c.(1780-1782)gaC>gaT	p.D594D	PIP5K1C_ENST00000589578.1_Silent_p.D594D|PIP5K1C_ENST00000539785.1_Silent_p.D594D|PIP5K1C_ENST00000537021.1_Silent_p.D594D	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	594					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CTCACCCTGCGTCCTCCTCTT	0.652000													16	49					0	0	1	0	0
ENO3	2027	broad.mit.edu	37	17	4859899	4859899	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:4859899G>A	ENST00000323997.6	+	10	1231	c.1099G>A	c.(1099-1101)Gtg>Atg	p.V367M	ENO3_ENST00000518175.1_Missense_Mutation_p.V367M|ENO3_ENST00000519584.1_Missense_Mutation_p.V324M	NM_001976.4|NM_053013.3	NP_001967.3|NP_443739.3	P13929	ENOB_HUMAN	enolase 3 (beta, muscle)	367					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)	15						TGGCTGGGGGGTGATGGTGAG	0.562000													47	125					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9576380	9576380	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:9576380A>G	ENST00000460593.1	+	7	1677	c.539A>G	c.(538-540)gAg>gGg	p.E180G	CPSF3_ENST00000238112.3_Missense_Mutation_p.E217G			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	217					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		AAACGTGAAGAGCGAGAAGCA	0.433000													35	94					0	0	1	0	0
SBNO2	22904	broad.mit.edu	37	19	1108811	1108811	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1108811G>A	ENST00000361757.3	-	31	3820	c.3583C>T	c.(3583-3585)Cgg>Tgg	p.R1195W	SBNO2_ENST00000587024.1_Missense_Mutation_p.R1185W|SBNO2_ENST00000438103.2_Missense_Mutation_p.R1138W	NM_014963.2	NP_055778.2	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 (Drosophila)	1195					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent					NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCTTCAGCCGCACGATCTGC	0.716000													9	20					0	0	1	0	0
LRRC2	79442	broad.mit.edu	37	3	46574323	46574323	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:46574323A>G	ENST00000395905.3	-	5	959	c.567T>C	c.(565-567)tgT>tgC	p.C189C	LRRC2_ENST00000296144.3_Silent_p.C189C	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	189										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		CTAGATTTTCACAATCTCCCA	0.368000													19	79					0	0	1	0	0
FAM86C1	55199	broad.mit.edu	37	11	71507071	71507071	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:71507071T>C	ENST00000359244.4	+	4	293	c.270T>C	c.(268-270)tgT>tgC	p.C90C	FAM86C1_ENST00000426628.2_Silent_p.C83C|FAM86C1_ENST00000528685.1_Silent_p.C56C|FAM86C1_ENST00000346333.6_Silent_p.C56C	NM_018172.2	NP_060642.2	Q9NVL1	FA86C_HUMAN	family with sequence similarity 86, member C1	90										lung(1)	1						AGACGTGCTGTATTGCCCAGA	0.617000													30	99					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739180	15739180	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:15739180T>C	ENST00000441682.2	+	0	1245							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CATCCCCCAATCCCTACATTC	0.622000													31	125					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38512091	38512091	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:38512091G>C	ENST00000332509.3	-	13	2053	c.1870C>G	c.(1870-1872)Cag>Gag	p.Q624E	PLA2G6_ENST00000335539.3_Missense_Mutation_p.Q570E|PLA2G6_ENST00000402064.1_Missense_Mutation_p.Q570E	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	624					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	CCTGAGGGCTGAGCTGGAGGC	0.592000													21	62					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66463372	66463372	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:66463372C>A	ENST00000383703.3	-	6	1317	c.714G>T	c.(712-714)gaG>gaT	p.E238D	LRIG1_ENST00000273261.3_Missense_Mutation_p.E238D			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	238						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCTTCAGCACCTCCAAGCTGT	0.542000													8	43					1.06961e-07	1.09985e-07	1	1	0
C15orf39	56905	broad.mit.edu	37	15	75501025	75501025	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:75501025C>T	ENST00000360639.2	+	2	2956	c.2636C>T	c.(2635-2637)tCg>tTg	p.S879L	C15orf39_ENST00000567617.1_Missense_Mutation_p.S879L|C15orf39_ENST00000394987.4_Missense_Mutation_p.S879L			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	879										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						ACCACGCTGTCGGAGGAGCGG	0.657000													6	16					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30732158	30732158	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30732158C>A	ENST00000262518.4	+	20	3497	c.3112C>A	c.(3112-3114)Cct>Act	p.P1038T	SRCAP_ENST00000395059.2_Missense_Mutation_p.P1038T|SRCAP_ENST00000344771.4_Missense_Mutation_p.P1038T	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1038	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCAGCCCACCCCTGGCCCAGT	0.667000													31	138					2.08457e-15	2.18432e-15	1	1	0
MUC13	56667	broad.mit.edu	37	3	124641065	124641065	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:124641065C>T	ENST00000311075.3	-	4	758	c.720G>A	c.(718-720)ttG>ttA	p.L240L		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	240	SEA.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						TTTCACTATGCAAGTCTTGAT	0.393000													14	49					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348957	89348957	+	Silent	SNP	G	G	A	rs141054850		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:89348957G>A	ENST00000301030.4	-	9	4453	c.3993C>T	c.(3991-3993)gaC>gaT	p.D1331D	ANKRD11_ENST00000378330.2_Silent_p.D1331D	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1331	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCGGCTTGTCGTCTCCAGGTG	0.592000													17	52					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15696932	15696932	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:15696932A>G	ENST00000281513.5	-	3	209	c.184T>C	c.(184-186)Ttt>Ctt	p.F62L	NBAS_ENST00000441750.1_Missense_Mutation_p.F62L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	62										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TGGCGTAAAAATAATAAACGA	0.274000													14	55					0	0	1	0	0
QTRTD1	79691	broad.mit.edu	37	3	113804627	113804627	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:113804627C>T	ENST00000281273.4	+	10	1381	c.1124C>T	c.(1123-1125)gCc>gTc	p.A375V	QTRTD1_ENST00000493014.1_Missense_Mutation_p.A269V|QTRTD1_ENST00000485050.1_Missense_Mutation_p.A387V|QTRTD1_ENST00000479882.1_Missense_Mutation_p.A252V	NM_024638.3	NP_078914.1	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain containing 1	375					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|skin(2)	10						GAGCTGCTGGCCGGAGTCCTG	0.478000													54	148					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2831230	2831230	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:2831230G>A	ENST00000442312.2	+	8	860	c.681G>A	c.(679-681)atG>atA	p.M227I	SH3BP2_ENST00000511747.1_Missense_Mutation_p.M199I|SH3BP2_ENST00000435136.2_Missense_Mutation_p.M199I|SH3BP2_ENST00000515183.1_3'UTR|SH3BP2_ENST00000503393.2_Missense_Mutation_p.M256I|SH3BP2_ENST00000356331.5_Missense_Mutation_p.M199I|SH3BP2_ENST00000452765.2_Missense_Mutation_p.M199I	NM_001145855.1	NP_001139327.1	P78314	3BP2_HUMAN	SH3-domain binding protein 2	199					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		ATGCCCTGATGCACCCACCGG	0.647000									Cherubism				40	115					0	0	1	0	0
LOC148709	148709	broad.mit.edu	37	1	202842810	202842810	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:202842810G>A	ENST00000456105.2	+	0	762					NR_002929.2																						CCCCAGCAAGGTACACAGCCA	0.577000													21	76					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7869267	7869267	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:7869267C>T	ENST00000264668.2	+	1	51	c.21C>T	c.(19-21)cgC>cgT	p.R7R	MTRR_ENST00000502509.1_Intron|MTRR_ENST00000341013.6_5'UTR	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	7					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CGTCAGTGCGCGCTGGCGCAA	0.672000													35	172					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32163578	32163578	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:32163578G>A	ENST00000373672.3	-	6	1102	c.586C>T	c.(586-588)Ccc>Tcc	p.P196S	COL16A1_ENST00000373668.3_Missense_Mutation_p.P196S|COL16A1_ENST00000271069.6_Missense_Mutation_p.P196S	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	196	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGTCGTCGGGGCCCCAGAGGC	0.622000													16	65					0	0	1	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71163099	71163099	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:71163099A>G	ENST00000234396.4	+	1	88	c.15A>G	c.(13-15)atA>atG	p.I5M	ATP6V1B1_ENST00000412314.1_Missense_Mutation_p.I5M	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	5					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						CCATGGAGATAGACAGCAGGC	0.637000													21	50					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87636213	87636213	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:87636213C>T	ENST00000376214.1	+	21	3316	c.2378C>T	c.(2377-2379)aCg>aTg	p.T793M	NTRK2_ENST00000277120.3_Missense_Mutation_p.T793M|NTRK2_ENST00000323115.4_Missense_Mutation_p.T777M|NTRK2_ENST00000376213.1_Missense_Mutation_p.T777M	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	777	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						CGACCCCGCACGTGCCCCCAG	0.552000										TSP Lung(25;0.17)			18	50					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135038213	135038213	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:135038213A>G	ENST00000304613.3	+	30	5090	c.5069A>G	c.(5068-5070)tAc>tGc	p.Y1690C	KNDC1_ENST00000368572.2_Missense_Mutation_p.Y1692C			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1690	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GAGAACCCTTACACCTTCAGC	0.602000													9	52					0	0	1	0	0
CXCL17	284340	broad.mit.edu	37	19	42933037	42933037	+	Nonstop_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42933037T>C	ENST00000601181.1	-	4	574	c.359A>G	c.(358-360)tAg>tGg	p.*120W	LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000457234.2_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000593740.2_RNA	NM_198477.1	NP_940879.1	Q6UXB2	VCC1_HUMAN	chemokine (C-X-C motif) ligand 17	0					angiogenesis|cell differentiation|chemotaxis	extracellular region				large_intestine(2)|skin(1)	3		Prostate(69;0.00899)				TCAGAGCTCCTACAAAGGCAG	0.493000													86	304					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231298757	231298757	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:231298757T>C	ENST00000444294.3	+	1	900	c.42T>C	c.(40-42)ttT>ttC	p.F14F	TRIM67_ENST00000366652.2_Silent_p.F14F|TRIM67_ENST00000366653.5_Silent_p.F14F|TRIM67_ENST00000449018.3_Silent_p.F14F	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	14						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GCTCTCTGTTTCGGGAGCCTA	0.667000													8	25					0	0	1	0	0
BHLHB9	80823	broad.mit.edu	37	X	102005445	102005445	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:102005445G>A	ENST00000372735.1	+	4	2107	c.1522G>A	c.(1522-1524)Gcc>Acc	p.A508T	BHLHB9_ENST00000457056.1_Missense_Mutation_p.A508T|BHLHB9_ENST00000361229.4_Missense_Mutation_p.A508T|BHLHB9_ENST00000447531.1_Missense_Mutation_p.A508T|BHLHB9_ENST00000448867.1_Missense_Mutation_p.A508T			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	508						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TAGTGGTGTGGCCATATTTAT	0.378000													4	103					0	0	1	0	0
TBC1D7	51256	broad.mit.edu	37	6	13307955	13307955	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:13307955A>G	ENST00000607658.1	-	5	611	c.461T>C	c.(460-462)tTg>tCg	p.L154S	TBC1D7_ENST00000356436.4_Missense_Mutation_p.L181S|TBC1D7_ENST00000379307.2_Missense_Mutation_p.L154S|TBC1D7_ENST00000379300.3_Missense_Mutation_p.L181S|TBC1D7_ENST00000343141.4_Missense_Mutation_p.L135S|TBC1D7_ENST00000607532.1_5'UTR			Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7	181	Rab-GAP TBC.				positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			TTCCAGATTCAAGTATTGTTC	0.408000													12	61					0	0	1	0	0
LAT2	7462	broad.mit.edu	37	7	73638350	73638350	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:73638350G>A	ENST00000460943.1	+	12	1340	c.451G>A	c.(451-453)Gcc>Acc	p.A151T	LAT2_ENST00000344995.5_Missense_Mutation_p.A151T|LAT2_ENST00000275635.7_Missense_Mutation_p.A151T|LAT2_ENST00000398475.1_Missense_Mutation_p.A151T	NM_032464.2	NP_115853.2	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family, member 2	151					B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6						CTCTGCAGGTGCCCAGCAGGA	0.637000													9	21					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31600487	31600487	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:31600487T>A	ENST00000389082.5	-	6	2110	c.1846A>T	c.(1846-1848)Act>Tct	p.T616S	DENND5B_ENST00000354285.4_Missense_Mutation_p.T638S|DENND5B_ENST00000306833.6_Missense_Mutation_p.T651S|DENND5B_ENST00000536562.1_Missense_Mutation_p.T651S	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	616						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TCTTTTAAAGTGCTGCATTTC	0.378000													7	37					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101750762	101750762	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:101750762G>T	ENST00000261637.4	+	43	5767	c.5593G>T	c.(5593-5595)Gca>Tca	p.A1865S		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1865					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CAGAGACATTGCACGCAGCAC	0.388000													15	78					2.32078e-09	2.39896e-09	1	1	0
MBP	4155	broad.mit.edu	37	18	74728931	74728931	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:74728931C>T	ENST00000397860.3	-	4	647	c.433G>A	c.(433-435)Gga>Aga	p.G145R	MBP_ENST00000355994.2_Missense_Mutation_p.G145R|MBP_ENST00000578193.1_Missense_Mutation_p.G12R|MBP_ENST00000528160.1_Missense_Mutation_p.G12R|MBP_ENST00000580402.1_Missense_Mutation_p.G145R|MBP_ENST00000354542.4_Missense_Mutation_p.G12R|MBP_ENST00000359645.3_Missense_Mutation_p.G12R|MBP_ENST00000526111.1_Intron|MBP_ENST00000397869.3_Missense_Mutation_p.G12R|MBP_ENST00000397866.4_Missense_Mutation_p.G12R|MBP_ENST00000397865.5_Missense_Mutation_p.G12R|MBP_ENST00000397863.1_Missense_Mutation_p.G145R|MBP_ENST00000382582.3_Missense_Mutation_p.G12R|MBP_ENST00000579129.1_Missense_Mutation_p.G145R|MBP_ENST00000397875.3_Missense_Mutation_p.G12R|MBP_ENST00000527041.1_Missense_Mutation_p.G12R	NM_001025100.1	NP_001020271.1	P02686	MBP_HUMAN	myelin basic protein	145					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		TACTTGGATCCGTGCCTCTGG	0.597000													37	67					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55238214	55238214	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:55238214A>T	ENST00000344576.2	+	16	2340	c.2095A>T	c.(2095-2097)Atc>Ttc	p.I699F	EGFR_ENST00000275493.2_Intron|EGFR_ENST00000454757.2_Intron|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Intron	NM_201284.1	NP_958441.1	P00533	EGFR_HUMAN	epidermal growth factor receptor	0	Important for dimerization, phosphorylation and activation.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATCTGTGATCATCACGGCCTC	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			39	100					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117849399	117849399	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:117849399T>C	ENST00000350763.4	-	3	1022	c.611A>G	c.(610-612)cAg>cGg	p.Q204R	TNC_ENST00000341037.4_Missense_Mutation_p.Q204R|TNC_ENST00000340094.3_Missense_Mutation_p.Q204R|TNC_ENST00000537320.1_Missense_Mutation_p.Q204R|TNC_ENST00000535648.1_Missense_Mutation_p.Q204R|TNC_ENST00000542877.1_Missense_Mutation_p.Q204R|TNC_ENST00000423613.2_Missense_Mutation_p.Q204R|TNC_ENST00000345230.3_Missense_Mutation_p.Q204R|TNC_ENST00000346706.3_Missense_Mutation_p.Q204R	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	204	EGF-like 2.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						ACAGATGCACTGCCCATCAAT	0.607000													38	108					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109629715	109629715	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:109629715T>C	ENST00000338432.7	+	15	2478	c.2359T>C	c.(2359-2361)Ttc>Ctc	p.F787L	ACACB_ENST00000377848.3_Missense_Mutation_p.F787L|ACACB_ENST00000377854.5_Missense_Mutation_p.F787L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	787					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CGATGCGATGTTCAGAACGTG	0.527000													4	114					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182631660	182631660	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:182631660A>G	ENST00000323116.5	+	29	3590	c.3330A>G	c.(3328-3330)acA>acG	p.T1110T		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	1110					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TTACTGAAACAAATGCAGGTA	0.423000													133	350					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41957354	41957354	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:41957354A>G	ENST00000298919.7	+	8	978	c.590A>G	c.(589-591)aAt>aGt	p.N197S	PDZRN4_ENST00000539469.2_Missense_Mutation_p.N199S|PDZRN4_ENST00000402685.2_Missense_Mutation_p.N457S			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	457							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTCTAGATAAATGGGGAAGAT	0.418000													5	62					0	0	1	0	0
IGHV1-46	28465	broad.mit.edu	37	14	106967567	106967567	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:106967567T>C	ENST00000390622.2	-	0	221																											GATGTATCCATATTTACCTCA	0.433000													13	21					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203059	140203059	+	Missense_Mutation	SNP	C	C	T	rs17844296		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140203059C>T	ENST00000529859.1	+	1	1699	c.1699C>T	c.(1699-1701)Cct>Tct	p.P567S	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.P567S|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.P567S|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCTGGTGCCTCGAGTGGG	0.716000													15	233					0	0	1	0	0
CCDC78	124093	broad.mit.edu	37	16	774151	774151	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:774151T>C	ENST00000293889.6	-	10	1113	c.1008A>G	c.(1006-1008)ccA>ccG	p.P336P		NM_001031737.2	NP_001026907.2	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	336										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(2)|skin(3)	9		Hepatocellular(780;0.0218)				GCACGGGCAATGGTTCCAGGT	0.627000													32	68					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49415624	49415624	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49415624T>C	ENST00000301067.7	-	54	16552	c.16553A>G	c.(16552-16554)gAc>gGc	p.D5518G		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GTGCTGATCGTCCTCAAAATC	0.507000													24	103					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545479	186545479	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:186545479G>A	ENST00000431808.1	-	14	1655	c.1092C>T	c.(1090-1092)aaC>aaT	p.N364N	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Silent_p.N268N|SORBS2_ENST00000284776.7_Silent_p.N364N|SORBS2_ENST00000355634.5_Silent_p.N464N|SORBS2_ENST00000449407.2_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	364						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGATTTCTGCGTTTTGCCGGG	0.517000													13	55					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149523280	149523280	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:149523280G>A	ENST00000378016.2	+	0	14366							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGCGACATCGGACTTGTGAG	0.657000													17	61					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5427892	5427892	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:5427892C>T	ENST00000399537.4	-	5	1911	c.1563G>A	c.(1561-1563)acG>acA	p.T521T	TNRC18_ENST00000430969.1_Silent_p.T521T			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	521							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGGCCATCTGCGTGGCGGCGA	0.701000													6	27					0	0	1	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313539	1313539	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:1313539C>T	ENST00000296839.2	+	1	865	c.600C>T	c.(598-600)agC>agT	p.S200S		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	200					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ACCCCAACAGCGAGTACACCT	0.716000													19	55					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99711975	99711975	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99711975G>T	ENST00000472509.1	-	1	206	c.29C>A	c.(28-30)cCc>cAc	p.P10H	TAF6_ENST00000453269.2_Intron|TAF6_ENST00000452041.1_Intron|TAF6_ENST00000437822.2_Intron|TAF6_ENST00000344095.4_Intron|TAF6_ENST00000418432.2_Intron|TAF6_ENST00000497233.1_Intron			P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	0					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGGAGACAGGGGAGGAACTC	0.567000													5	6					0.000602214	0.000609374	1	1	0
TRIO	7204	broad.mit.edu	37	5	14487613	14487613	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:14487613G>C	ENST00000344204.4	+	48	6900	c.6876G>C	c.(6874-6876)ggG>ggC	p.G2292G	TRIO_ENST00000537187.1_Silent_p.G2292G	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2292	Poly-Gly.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					ACCACAgcgggggcggcggcg	0.756000													9	24					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96437210	96437210	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:96437210T>C	ENST00000359246.4	+	19	2995	c.2626_splice	c.e19-1	p.V876_splice	PHF2_ENST00000375376.4_Splice_Site_p.V107_splice	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	876					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		TCCCTCTAGTTTACCCCTCAC	0.612000													24	79					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137328392	137328392	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:137328392C>T	ENST00000540193.1	+	9	1953	c.1030C>T	c.(1030-1032)Ctc>Ttc	p.L344F	RXRA_ENST00000481739.1_Missense_Mutation_p.L441F|RXRA_ENST00000356384.4_3'UTR			P19793	RXRA_HUMAN	retinoid X receptor, alpha	441	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CTTCTTCAAGCTCATCGGGGA	0.587000													7	144					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915701	119915701	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:119915701G>A	ENST00000331113.4	+	1	1980	c.1015G>A	c.(1015-1017)Gct>Act	p.A339T		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	339					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CATCATCTTCGCTACAGTTAT	0.517000													27	89					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88753124	88753124	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:88753124A>G	ENST00000444431.1	+	0	70				RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										AATAGGACTCAGGATTTGAAG	0.348000													20	56					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36221448	36221448	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:36221448G>T	ENST00000420124.1	+	25	5207	c.5207G>T	c.(5206-5208)cGc>cTc	p.R1736L	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.R1736L																							GGTTCCATCCGCATTGACTCC	0.612000													6	553					3.59834e-05	3.66827e-05	1	1	0
BOD1L1	259282	broad.mit.edu	37	4	13578511	13578511	+	Missense_Mutation	SNP	C	C	T	rs140860052		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:13578511C>T	ENST00000040738.5	-	25	9124	c.8989G>A	c.(8989-8991)Gag>Aag	p.E2997K		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2997	Poly-Glu.						DNA binding										CCTGAAGGctcgtcctcttcc	0.527000													8	173					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46931225	46931225	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46931225C>T	ENST00000262738.3	-	1	1842	c.1843G>A	c.(1843-1845)Ggc>Agc	p.G615S	CELSR1_ENST00000395964.1_Missense_Mutation_p.G615S	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	615	Cadherin 4.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCAGCGCTGCCGCCCCCCAGA	0.652000													9	57					0	0	1	0	0
VIPR2	7434	broad.mit.edu	37	7	158829514	158829514	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:158829514T>G	ENST00000262178.2	-	7	862	c.677A>C	c.(676-678)tAc>tCc	p.Y226S	VIPR2_ENST00000377633.3_Missense_Mutation_p.Y210S|VIPR2_ENST00000402066.1_Missense_Mutation_p.Y367S	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	226					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		GGTGTGGAGGTAGAGCCCCTC	0.602000													5	57					0	0	1	0	0
HSF1	3297	broad.mit.edu	37	8	145533482	145533482	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145533482A>G	ENST00000528838.1	+	4	548	c.388A>G	c.(388-390)Ata>Gta	p.I130V	HSF1_ENST00000400780.4_Missense_Mutation_p.I65V	NM_005526.2	NP_005517.1	Q00613	HSF1_HUMAN	heat shock transcription factor 1	130	Hydrophobic repeat HR-A/B.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)|urinary_tract(2)	11	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			GAGTGAAGACATAAAGATCCG	0.592000													10	137					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271697	164271697	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:164271697T>C	ENST00000515560.1	+	4	1794	c.272T>C	c.(271-273)gTg>gCg	p.V91A	NPY5R_ENST00000338566.3_Missense_Mutation_p.V91A|NPY5R_ENST00000506953.1_Missense_Mutation_p.V91A			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	91					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ATCTTGGTTGTGCTGTTTTGC	0.413000													65	225					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123318930	123318930	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:123318930A>G	ENST00000275162.4	+	2	1343	c.8A>G	c.(7-9)cAt>cGt	p.H3R	CLVS2_ENST00000368438.1_Intron	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	3					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						ACAATGACTCATTTGCAAGCC	0.557000													21	62					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52159635	52159635	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52159635A>C	ENST00000354534.5	+	16	2903	c.2725A>C	c.(2725-2727)Aac>Cac	p.N909H	SCN8A_ENST00000545061.1_Missense_Mutation_p.N909H|SCN8A_ENST00000550891.1_Missense_Mutation_p.N909H	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	909					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CTGCAAGATCAACCAGGACTG	0.493000													4	191					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	75					0	0	1	0	0
ELMSAN1	91748	broad.mit.edu	37	14	74206218	74206218	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:74206218A>G	ENST00000286523.5	-	2	1276	c.494T>C	c.(493-495)cTg>cCg	p.L165P	ELMSAN1_ENST00000394071.2_Missense_Mutation_p.L165P	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		CTCCCGCTTCAGTGCCTCAGG	0.617000													39	161					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81205381	81205381	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:81205381T>A	ENST00000552864.1	-	5	767	c.565A>T	c.(565-567)Acc>Tcc	p.T189S		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	189	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						ACTTTTGGGGTGTATCGCACC	0.493000													7	70					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58256134	58256134	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:58256134C>G	ENST00000249750.4	-	9	1802	c.1035G>C	c.(1033-1035)aaG>aaC	p.K345N	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.K324N|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.K307N|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.K316N|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.K249N	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	345					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CTACGCGCCTCTTGGCCCGCT	0.522000													22	110					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47408411	47408411	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:47408411A>G	ENST00000398879.1	-	17	2198	c.1832T>C	c.(1831-1833)cTg>cCg	p.L611P	TNS3_ENST00000311160.9_Missense_Mutation_p.L611P|TNS3_ENST00000355730.3_Missense_Mutation_p.L371P			Q68CZ2	TENS3_HUMAN	tensin 3	611						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GCGGCTCACCAGCCGGGCCTC	0.657000													4	107					0	0	1	0	0
RPL32P3	132241	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													7	211					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767872	77767872	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:77767872G>A	ENST00000521891.2	+	10	9163	c.8715G>A	c.(8713-8715)gcG>gcA	p.A2905A	ZFHX4_ENST00000518282.1_Silent_p.A2879A|ZFHX4_ENST00000455469.2_Silent_p.A2860A|ZFHX4_ENST00000050961.6_Silent_p.A2860A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2860						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAGCATAGCGGACCCGAGCT	0.507000										HNSCC(33;0.089)			36	66					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149360191	149360191	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:149360191A>G	ENST00000286298.4	+	3	1303	c.1035A>G	c.(1033-1035)ttA>ttG	p.L345L		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	345						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CAGCCACATTAGCCTCTCATT	0.383000													4	92					0	0	1	0	0
C11orf84	144097	broad.mit.edu	37	11	63581183	63581183	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:63581183G>A	ENST00000294244.4	+	1	324	c.25G>A	c.(25-27)Gca>Aca	p.A9T		NM_138471.1	NP_612480.1	Q9BUA3	CK084_HUMAN	chromosome 11 open reading frame 84	9										endometrium(3)|kidney(1)|lung(3)|skin(1)	8						CGAGGGCGCCGCACTCGACTG	0.701000													3	14					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61412691	61412691	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:61412691T>C	ENST00000395348.3	-	6	2005	c.1369A>G	c.(1369-1371)Acc>Gcc	p.T457A	SLC16A9_ENST00000395347.1_Missense_Mutation_p.T457A	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	457					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						TAGGTCTGGGTCCAGTCATAA	0.398000													9	86					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44428821	44428821	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:44428821A>G	ENST00000378551.2	+	2	895	c.483A>G	c.(481-483)caA>caG	p.Q161Q	PPM1B_ENST00000409432.3_Silent_p.Q161Q|PPM1B_ENST00000409895.4_Silent_p.Q161Q|PPM1B_ENST00000345249.4_Intron|PPM1B_ENST00000282412.4_Silent_p.Q161Q|PPM1B_ENST00000378540.4_3'UTR	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	161					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGAATGGACAAGTCTGCTTTT	0.438000													40	104					0	0	1	0	0
SMG6	23293	broad.mit.edu	37	17	2090120	2090120	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:2090120G>A	ENST00000544865.1	-	12	3409	c.2899C>T	c.(2899-2901)Ctg>Ttg	p.L967L	SMG6_ENST00000536871.2_Silent_p.L90L|SMG6_ENST00000263073.5_Silent_p.L998L|SMG6_ENST00000354901.4_Silent_p.L90L			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor	998					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GGAGAGGACAGCTGAGCTGCA	0.597000													7	35					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24791326	24791326	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24791326G>A	ENST00000310677.4	-	21	2645	c.2532C>T	c.(2530-2532)aaC>aaT	p.N844N	ADCY4_ENST00000418030.2_Silent_p.N844N|ADCY4_ENST00000554068.2_Silent_p.N844N	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	844					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		CAGGGAGCACGTTCTCCAAGA	0.612000													5	190					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59544957	59544957	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:59544957G>A	ENST00000393853.4	+	5	651	c.488G>A	c.(487-489)cGg>cAg	p.R163Q	TBX4_ENST00000240335.1_Missense_Mutation_p.R163Q			P57082	TBX4_HUMAN	T-box 4	163					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CACTGGATGCGGCAGCTGGTC	0.612000													27	73					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726367	168726367	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:168726367G>A	ENST00000305861.1	+	2	1169	c.818G>A	c.(817-819)cGa>cAa	p.R273Q	AC016723.4_ENST00000430546.1_RNA|AC016723.4_ENST00000436982.2_RNA|B3GALT1_ENST00000392690.2_Missense_Mutation_p.R273Q	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	273					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						CTGTGTCTTCGAAAGCTGGGC	0.468000													19	67					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123301398	123301398	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:123301398T>C	ENST00000296513.2	+	3	357		c.e3+2		ADAD1_ENST00000388725.2_Splice_Site|ADAD1_ENST00000388724.2_Splice_Site	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)						multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						AAGTAACGGGTACGACTTTTT	0.438000													26	62					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64067503	64067503	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:64067503A>T	ENST00000443617.2	-	2	407	c.320T>A	c.(319-321)cTg>cAg	p.L107Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	107					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GAGTACAAGCAGTCGTTTTCT	0.478000													14	70					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32221928	32221928	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:32221928C>T	ENST00000373658.3	-	4	851	c.510G>A	c.(508-510)ccG>ccA	p.P170P	BAI2_ENST00000398556.3_Silent_p.P173P|BAI2_ENST00000398542.1_Silent_p.P158P|BAI2_ENST00000373655.2_Silent_p.P170P|BAI2_ENST00000398538.1_Silent_p.P158P|BAI2_ENST00000257070.4_Silent_p.P170P|BAI2_ENST00000398547.1_Silent_p.P158P|BAI2_ENST00000527361.1_Silent_p.P170P	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	170					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CCAGCAGGCGCGGGGCCTCGG	0.622000													27	79					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49712931	49712931	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:49712931T>C	ENST00000492622.2	+	7	1114	c.809T>C	c.(808-810)gTc>gCc	p.V270A	FNDC3A_ENST00000398316.3_Missense_Mutation_p.V214A|FNDC3A_ENST00000541916.1_Missense_Mutation_p.V270A	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	270	Fibronectin type-III 1.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TCCAACATTGTCAAACCAGTG	0.229000													7	39					0	0	1	0	0
LHFPL2	10184	broad.mit.edu	37	5	77805875	77805875	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:77805875C>T	ENST00000380345.2	-	4	837	c.162G>A	c.(160-162)ccG>ccA	p.P54P	LHFPL2_ENST00000515007.2_Silent_p.P54P	NM_005779.2	NP_005770.1	Q6ZUX7	LHPL2_HUMAN	lipoma HMGIC fusion partner-like 2	54						integral to membrane				endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	6		all_lung(232;0.000409)|Lung NSC(167;0.00108)|Ovarian(174;0.0107)|Prostate(461;0.218)		OV - Ovarian serous cystadenocarcinoma(54;6.48e-46)|Epithelial(54;8.43e-42)|all cancers(79;1.42e-36)		GGTAGGGCTCCGGGGAgcccc	0.706000													9	24					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15694557	15694557	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:15694557A>G	ENST00000396368.3	-	24	4834	c.4626_splice	c.e24-1	p.V1543_splice	KIAA0430_ENST00000344181.3_Intron|KIAA0430_ENST00000540441.2_Splice_Site_p.V1378_splice|KIAA0430_ENST00000548025.1_Splice_Site_p.V1540_splice|KIAA0430_ENST00000551742.1_Splice_Site_p.V1543_splice|KIAA0430_ENST00000602337.1_Splice_Site_p.V1540_splice	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1542						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TATCCAGACCACCTGCACACA	0.458000													4	178					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23635670	23635670	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23635670G>A	ENST00000316902.7	-	2	956	c.231C>T	c.(229-231)atC>atT	p.I77I	SLC7A8_ENST00000469263.1_Silent_p.I77I	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	77					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CAATCCAGACGATGAGAGCAA	0.542000													91	346					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116299133	116299133	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:116299133T>C	ENST00000374140.2	+	20	2181	c.1972T>C	c.(1972-1974)Tgc>Cgc	p.C658R	RGS3_ENST00000343817.5_Missense_Mutation_p.C377R|RGS3_ENST00000317613.6_Missense_Mutation_p.C546R|RGS3_ENST00000462143.1_5'UTR|RGS3_ENST00000350696.5_Missense_Mutation_p.C658R|RGS3_ENST00000394646.3_Missense_Mutation_p.C377R|RGS3_ENST00000374136.1_Missense_Mutation_p.C284R	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	658					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GAAGAGAGTGTGCTGGTGCCT	0.582000													8	157					0	0	1	0	0
MIR101-1	406893	broad.mit.edu	37	1	65524139	65524139	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:65524139T>C	ENST00000362265.1	-	0	52					NR_029516.1																						GTTATCACAGTACTGTACCTT	0.507000													3	65					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131371248	131371248	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131371248C>T	ENST00000358161.5	+	35	4700	c.4587C>T	c.(4585-4587)gtC>gtT	p.V1529V	SPTAN1_ENST00000372731.4_Silent_p.V1529V|SPTAN1_ENST00000372739.3_Silent_p.V1529V			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1529					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GCAATGAGGTCTTGGACAGGT	0.582000													5	275					0	0	1	0	0
TTC38	55020	broad.mit.edu	37	22	46685777	46685777	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46685777G>A	ENST00000381031.3	+	13	1373	c.1297G>A	c.(1297-1299)Gtc>Atc	p.V433I	TTC38_ENST00000445282.2_Missense_Mutation_p.V375I	NM_017931.2	NP_060401.2	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	433							binding			endometrium(4)|large_intestine(3)|lung(4)|ovary(1)	12						CACCTCCAGCGTCCATAAGAA	0.597000													29	74					0	0	1	0	0
ACTL6B	51412	broad.mit.edu	37	7	100244703	100244703	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100244703G>A	ENST00000160382.5	-	10	933	c.827C>T	c.(826-828)gCt>gTt	p.A276V		NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B	276					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CATTTGTGCAGCCACCCTACC	0.627000													18	56					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397539	125397539	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:125397539T>C	ENST00000536769.1	-	1	2355	c.779A>G	c.(778-780)gAc>gGc	p.D260G	UBC_ENST00000546120.1_Missense_Mutation_p.D184G|UBC_ENST00000538617.1_Intron|UBC_ENST00000339647.5_Missense_Mutation_p.D260G			P0CG48	UBC_HUMAN	ubiquitin C	260	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GCCTTCCTTGTCTTGGATCTT	0.517000													55	356					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52637555	52637555	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52637555G>A	ENST00000356770.4	-	16	2667	c.2665C>T	c.(2665-2667)Cga>Tga	p.R889*	PBRM1_ENST00000296302.7_Nonsense_Mutation_p.R921*|PBRM1_ENST00000409767.1_Nonsense_Mutation_p.R936*|PBRM1_ENST00000394830.3_Nonsense_Mutation_p.R921*|PBRM1_ENST00000409114.3_Nonsense_Mutation_p.R936*|PBRM1_ENST00000409057.1_Nonsense_Mutation_p.R921*|PBRM1_ENST00000410007.1_Nonsense_Mutation_p.R921*|PBRM1_ENST00000337303.4_Nonsense_Mutation_p.R921*			Q86U86	PB1_HUMAN	polybromo 1	921					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.R921*(2)|p.R889*(1)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCTTCTTCTCGTTTTAGTTTA	0.343000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								8	19					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810721	65810721	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65810721G>A	ENST00000312006.4	-	3	834	c.553C>T	c.(553-555)Cgc>Tgc	p.R185C	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.R185C	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	185					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						TCGGGCGCGCGCAGGAAGGCC	0.682000													23	55					0	0	1	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40639195	40639195	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:40639195A>G	ENST00000343619.4	+	10	956	c.833A>G	c.(832-834)cAc>cGc	p.H278R	ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.H278R|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.H278R|ATP6V0A1_ENST00000544137.1_Intron|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.H235R|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.H235R|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.H285R	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	278					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		ACGGAGGATCACCGCCAGAGG	0.493000													43	105					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126715969	126715969	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:126715969T>C	ENST00000309035.6	-	1	490	c.360A>G	c.(358-360)gtA>gtG	p.V120V	CTBP2_ENST00000494626.2_Intron|CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000337195.5_Intron|CTBP2_ENST00000411419.2_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GCTCTTTGGGTACCCTAGCAG	0.612000													9	107					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117822164	117822164	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:117822164A>G	ENST00000350763.4	-	14	4562	c.4151T>C	c.(4150-4152)gTc>gCc	p.V1384A	TNC_ENST00000341037.4_Missense_Mutation_p.V1293A|TNC_ENST00000340094.3_Intron|TNC_ENST00000537320.1_Intron|TNC_ENST00000535648.1_Intron|TNC_ENST00000542877.1_Intron|TNC_ENST00000423613.2_Missense_Mutation_p.V1384A|TNC_ENST00000345230.3_Intron|TNC_ENST00000346706.3_Intron	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1384	Fibronectin type-III 9.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CACTTTGTTGACCTCCTGCAC	0.582000													43	66					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098605	78098605	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:78098605T>C	ENST00000370801.3	-	5	910	c.435A>G	c.(433-435)gaA>gaG	p.E145E	ZZZ3_ENST00000370798.1_Intron	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						TACTCCTCTGTTCTACTGACT	0.368000													23	183					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201437985	201437985	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:201437985T>C	ENST00000357799.4	+	7	3014	c.2916T>C	c.(2914-2916)agT>agC	p.S972S		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	972					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						AAAAGGAAAGTTGTGATCAAA	0.279000													16	58					0	0	1	0	0
KLRK1	22914	broad.mit.edu	37	12	10531151	10531151	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:10531151A>G	ENST00000240618.6	-	6	570		c.e6+1		KLRC4-KLRK1_ENST00000539300.1_Splice_Site|KLRK1_ENST00000540818.1_Splice_Site|RP11-277P12.20_ENST00000500682.1_RNA	NM_001199805.1|NM_007360.3	NP_001186734.1|NP_031386.2	P26718	NKG2D_HUMAN	killer cell lectin-like receptor subfamily K, member 1						natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)	9						TAAATACTCAACCTGGTCCTC	0.378000													10	62					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458064	248458064	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248458064A>G	ENST00000317996.1	-	1	816	c.817T>C	c.(817-819)Tca>Cca	p.S273P		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TAGAAGGCTGACACAACCTTA	0.488000													33	150					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24835045	24835045	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:24835045G>A	ENST00000395799.3	+	25	5935	c.5806G>A	c.(5806-5808)Gac>Aac	p.D1936N	TNRC6A_ENST00000315183.7_Missense_Mutation_p.D1887N|TNRC6A_ENST00000432286.2_Missense_Mutation_p.D414N	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1936	Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		AAGCAGCAGCGACCCCCGAGG	0.567000													53	157					0	0	1	0	0
FAM211A	388341	broad.mit.edu	37	17	16347048	16347048	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:16347048T>C	ENST00000470794.1	-	4	916	c.889A>G	c.(889-891)Acc>Gcc	p.T297A	C17orf76-AS1_ENST00000579473.1_RNA|C17orf76-AS1_ENST00000478103.2_RNA|C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|C17orf76-AS1_ENST00000472367.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA|FAM211A_ENST00000409083.3_3'UTR	NM_001113567.2	NP_001107039.1	Q8NAA5	CQ076_HUMAN	family with sequence similarity 211, member A	297										lung(1)	1						TCCAGGATGGTGGGTAGGTGG	0.667000													10	37					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917503	26917503	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:26917503T>C	ENST00000539517.2	-	5	1503	c.1186A>G	c.(1186-1188)Aat>Gat	p.N396D	NOVA1_ENST00000267422.7_Missense_Mutation_p.N274D|NOVA1_ENST00000465357.2_Missense_Mutation_p.N372D	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	399	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		AAATATCCATTGGTTGCAGCA	0.537000													14	45					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	236959026	236959026	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:236959026T>C	ENST00000366577.5	+	1	417	c.23T>C	c.(22-24)cTg>cCg	p.L8P	MTR_ENST00000418145.2_Missense_Mutation_p.C136R|MTR_ENST00000535889.1_Missense_Mutation_p.L8P	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	8					nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CTCCAAGACCTGTCGCAACCC	0.627000													20	70					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21721179	21721179	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21721179A>G	ENST00000328843.6	+	31	5390	c.5359A>G	c.(5359-5361)Aca>Gca	p.T1787A	DNAH11_ENST00000409508.3_Missense_Mutation_p.T1782A			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1787	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCAGCTGAATACACTGATTAC	0.393000									Kartagener syndrome				3	33					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28218619	28218619	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:28218619C>T	ENST00000344423.5	-	2	154	c.23G>A	c.(22-24)cGc>cAc	p.R8H	ZNF395_ENST00000523202.1_Missense_Mutation_p.R8H|ZNF395_ENST00000523095.1_Missense_Mutation_p.R8H	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	8					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		CTTTCCAAGGCGTCGGGACAG	0.677000													34	60					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30675572	30675572	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30675572G>A	ENST00000376406.3	-	8	3431	c.2784C>T	c.(2782-2784)tgC>tgT	p.C928C	MDC1_ENST00000376405.2_Intron|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	928				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CGGCTGGATCGCACTCTCTGT	0.507000								Other conserved DNA damage response genes					36	121					0	0	1	0	0
THAP9	79725	broad.mit.edu	37	4	83839815	83839815	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:83839815T>C	ENST00000302236.5	+	5	2501	c.2450T>C	c.(2449-2451)gTg>gCg	p.V817A	LIN54_ENST00000505905.1_Intron	NM_024672.4	NP_078948.3	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	817							DNA binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(13)|lung(5)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(3)	33		Hepatocellular(203;0.114)				TTTGTAGATGTGAATAAGCAT	0.308000													25	54					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18743175	18743175	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18743175T>C	ENST00000513874.1	-	4	424	c.285A>G	c.(283-285)aaA>aaG	p.K95K	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	95	Ig-like 1.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						AGATGTGGGGTTTGGCGTTCC	0.597000											OREG0020822	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	136					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64524953	64524953	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:64524953C>T	ENST00000498707.1	-	37	5881	c.5539G>A	c.(5539-5541)Gca>Aca	p.A1847T	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.A1819T	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1847	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CTTGTCCTTGCAAACTGTAAG	0.552000													15	52					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24247074	24247074	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:24247074A>G	ENST00000338315.4	+	13	1423	c.1423A>G	c.(1423-1425)Atc>Gtc	p.I475V	MFSD2B_ENST00000406420.3_Missense_Mutation_p.I475V			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	475					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						TGGGCTCTGCATCCTCATGGT	0.642000													6	33					0	0	1	0	0
PI3	5266	broad.mit.edu	37	20	43804535	43804535	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:43804535G>A	ENST00000243924.3	+	2	160	c.113G>A	c.(112-114)cGt>cAt	p.R38H		NM_002638.3	NP_002629.1	P19957	ELAF_HUMAN	peptidase inhibitor 3, skin-derived	38	2 X tandem repeats of SVP-1 like motif.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity			large_intestine(1)|lung(5)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				GTCAAAGGCCGTGTTCCATTC	0.443000													42	130					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117222548	117222548	+	Silent	SNP	C	C	T	rs149281923		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:117222548C>T	ENST00000278935.3	+	5	384	c.237C>T	c.(235-237)aaC>aaT	p.N79N		NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	79	Interaction with ATRIP.|WW.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		ACTTCGCCAACGGGCAGTCTA	0.478000													26	102					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130647821	130647821	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:130647821C>T	ENST00000229030.4	+	1	818	c.334C>T	c.(334-336)Cag>Tag	p.Q112*	FZD10_ENST00000539839.1_Missense_Mutation_p.A79V			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	112	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CATGTGCGAGCAGGCCCGGCT	0.632000													33	207					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129907004	129907004	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:129907004C>A	ENST00000368654.3	-	13	3475	c.3100G>T	c.(3100-3102)Gtg>Ttg	p.V1034L	MKI67_ENST00000368653.3_Missense_Mutation_p.V674L	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1034	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTTCTTTCACACCTACTTTC	0.507000													11	672					0.00010058	0.000102188	1	1	0
FMN2	56776	broad.mit.edu	37	1	240370643	240370643	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:240370643C>G	ENST00000319653.9	+	5	2761	c.2531C>G	c.(2530-2532)tCt>tGt	p.S844C		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	844	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CACGAACACTCTGTTTCCTCT	0.562000													32	113					0	0	1	0	0
EN1	2019	broad.mit.edu	37	2	119600542	119600542	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:119600542G>A	ENST00000295206.6	-	2	1661	c.1151C>T	c.(1150-1152)aCg>aTg	p.T384M		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	384					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						GTCCTGGACCGTGGTGGTGGA	0.687000													13	56					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815131	43815131	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43815131A>G	ENST00000382031.1	+	5	2205	c.2174A>G	c.(2173-2175)gAc>gGc	p.D725G	MAP1A_ENST00000300231.5_Missense_Mutation_p.D487G|MAP1A_ENST00000399453.1_Missense_Mutation_p.D487G			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	487						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GTCAAAATAGACAGGAGCCGT	0.542000													5	33					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184930607	184930607	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:184930607G>A	ENST00000308497.4	+	3	2051	c.616G>A	c.(616-618)Gtg>Atg	p.V206M	STOX2_ENST00000438269.1_Missense_Mutation_p.V206M	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	206					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CAGAGAAGACGTGCACAGCAC	0.592000													28	92					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3629040	3629040	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:3629040A>G	ENST00000325418.4	+	1	1830	c.1811A>G	c.(1810-1812)gAa>gGa	p.E604G	ITGAE_ENST00000571185.1_Intron|ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	604	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										ATTGTGCTGGAATTTGAGTTT	0.473000													49	105					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247014460	247014460	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:247014460T>C	ENST00000366508.1	-	33	5089	c.4953A>G	c.(4951-4953)aaA>aaG	p.K1651K	AHCTF1_ENST00000326225.3_Silent_p.K1625K|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Silent_p.K1616K			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1616	Mediates transcriptional activity (By similarity).|Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGTTAGCTGCTTTAGGTAACA	0.403000													23	81					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	55999741	55999741	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:55999741C>T	ENST00000313264.4	-	1	996	c.921G>A	c.(919-921)tcG>tcA	p.S307S		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S307S(1)		endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TGTCATGGTCCGAAGCATAGC	0.408000													6	191					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89927085	89927085	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:89927085C>T	ENST00000389297.4	+	16	2049	c.1798C>T	c.(1798-1800)Ccc>Tcc	p.P600S	C7orf63_ENST00000316089.8_Missense_Mutation_p.P600S|C7orf63_ENST00000497910.1_Missense_Mutation_p.P582S	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	600							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						GGGATGTTATCCCTCAGAGGA	0.289000													14	66					0	0	1	0	0
YY1	7528	broad.mit.edu	37	14	100706061	100706061	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:100706061C>T	ENST00000262238.4	+	1	740	c.480C>T	c.(478-480)ggC>ggT	p.G160G		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	160	Gly/Ser-rich.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				gcaagagcggcggcggcggct	0.716000													7	18					0	0	1	0	0
HYAL2	8692	broad.mit.edu	37	3	50355698	50355698	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:50355698C>T	ENST00000447092.1	-	3	3576	c.1284G>A	c.(1282-1284)caG>caA	p.Q428Q	HYAL2_ENST00000357750.4_Silent_p.Q428Q|HYAL2_ENST00000395139.3_Silent_p.Q428Q|HYAL2_ENST00000442581.1_Silent_p.Q428Q			Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2	428	EGF-like.					anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			breast(1)|endometrium(2)|kidney(1)|ovary(1)|prostate(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	CCAAGTAGCACTGGCAGCGGA	0.647000													18	63					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47429119	47429119	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:47429119C>T	ENST00000285039.7	-	21	2955	c.2656G>A	c.(2656-2658)Gca>Aca	p.A886T	MYO5B_ENST00000324581.6_Missense_Mutation_p.A27T	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	886	Arg-rich.|IQ 5.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		ACAATGGCTGCATCCCGCAGC	0.627000													22	46					0	0	1	0	0
BDKRB2	624	broad.mit.edu	37	14	96707261	96707261	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:96707261A>G	ENST00000542454.2	+	3	3603	c.515A>G	c.(514-516)aAg>aGg	p.K172R	BDKRB2_ENST00000539359.1_Missense_Mutation_p.K172R|BDKRB2_ENST00000554311.1_Missense_Mutation_p.K199R|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000306005.3_Missense_Mutation_p.K199R			P30411	BKRB2_HUMAN	bradykinin receptor B2	199					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		CGGACCATGAAGGAGTACAGC	0.602000													25	74					0	0	1	0	0
SLC35D3	340146	broad.mit.edu	37	6	137245154	137245154	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:137245154T>C	ENST00000331858.4	+	2	736	c.571T>C	c.(571-573)Tac>Cac	p.Y191H		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	191					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		CACCGCGCAGTACGTCATCGC	0.682000													3	23					0	0	1	0	0
TAP2	6891	broad.mit.edu	37	6	32797232	32797232	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32797232C>T	ENST00000374897.2	-	11	2008	c.1877G>A	c.(1876-1878)cGg>cAg	p.R626Q	TAP2_ENST00000374899.4_Missense_Mutation_p.R626Q|TAP2_ENST00000452392.2_Missense_Mutation_p.R626Q	NM_000544.3	NP_000535.3	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	626	ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										GATGAGGACCCGCGGGTCTCG	0.617000													5	19					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121106804	121106804	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:121106804G>A	ENST00000295228.3	+	2	624	c.578G>A	c.(577-579)aGc>aAc	p.S193N		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	193					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				GAGAAGGGCAGCCGGCGGAAG	0.592000													29	89					0	0	1	0	0
RNF41	10193	broad.mit.edu	37	12	56601481	56601481	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56601481T>C	ENST00000345093.4	-	6	920	c.551A>G	c.(550-552)aAc>aGc	p.N184S	RNF41_ENST00000552656.1_Missense_Mutation_p.N184S|RNF41_ENST00000394013.2_Missense_Mutation_p.N113S|RNF41_ENST00000552244.1_Missense_Mutation_p.N184S	NM_005785.3|NM_194359.2	NP_005776.1|NP_919340.1	Q9H4P4	RNF41_HUMAN	ring finger protein 41	184					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	11						AAGGTTGGGGTTGACACTGCG	0.488000													4	335					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131940675	131940675	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:131940675T>C	ENST00000378823.3	+	16	3103	c.2285T>C	c.(2284-2286)tTg>tCg	p.L762S	RAD50_ENST00000265335.6_Missense_Mutation_p.L901S	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	901					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTCAGTCTTTGTACAGAGAG	0.318000								Homologous recombination					15	26					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19470408	19470408	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:19470408G>A	ENST00000270570.4	+	14	1262		c.e14-1		RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000575023.1_Intron|SLC47A1_ENST00000436810.2_Splice_Site|SLC47A1_ENST00000395585.1_Splice_Site|SLC47A1_ENST00000571335.1_Splice_Site|SLC47A1_ENST00000457293.1_Splice_Site	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1							integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TCTGCCTGCAGTGCACGAGTG	0.517000													22	323					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64067489	64067489	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:64067489G>A	ENST00000443617.2	-	2	421	c.334C>T	c.(334-336)Cgt>Tgt	p.R112C		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	112					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TAAAAGACACGCTGGAGTACA	0.473000													37	58					0	0	1	0	0
DHFRL1	200895	broad.mit.edu	37	3	93780281	93780281	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:93780281C>T	ENST00000394221.2	-	2	524	c.75G>A	c.(73-75)agG>agA	p.R25R	DHFRL1_ENST00000481631.1_5'UTR|DHFRL1_ENST00000314636.2_Silent_p.R25R	NM_001195643.1	NP_001182572.1	Q86XF0	DYRL1_HUMAN	dihydrofolate reductase-like 1	25	DHFR.				glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process		dihydrofolate reductase activity|NADP binding			kidney(1)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	8						TGAGCGGCGGCCTGGGCAGGT	0.502000													12	162					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620598	7620598	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:7620598A>T	ENST00000486284.1	+	8	2279	c.2005A>T	c.(2005-2007)Agt>Tgt	p.S669C	GRM7_ENST00000389336.4_Missense_Mutation_p.S669C|GRM7_ENST00000402647.2_Missense_Mutation_p.S669C|GRM7_ENST00000403881.1_Missense_Mutation_p.S669C|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000357716.4_Missense_Mutation_p.S669C	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	669					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TATGTGCATCAGTTATGCAGC	0.448000													25	80					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32774849	32774849	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:32774849C>T	ENST00000265074.8	+	4	1438	c.1095C>T	c.(1093-1095)atC>atT	p.I365I	NPR3_ENST00000415685.2_Silent_p.I149I|NPR3_ENST00000415167.2_Silent_p.I365I|NPR3_ENST00000434067.2_Silent_p.I149I	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	365					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	ACGATGCCATCCTCCTCTACG	0.433000													67	178					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128411046	128411046	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:128411046C>T	ENST00000368227.3	-	8	1620	c.1254G>A	c.(1252-1254)acG>acA	p.T418T	PTPRK_ENST00000368215.3_Silent_p.T418T|PTPRK_ENST00000368207.3_Silent_p.T418T|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Silent_p.T418T|PTPRK_ENST00000368226.4_Silent_p.T418T|PTPRK_ENST00000368210.3_Silent_p.T418T|PTPRK_ENST00000532331.1_Silent_p.T418T			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	418	Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TGTGGCAACGCGTAATGTTGT	0.463000													19	74					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	863782	863782	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:863782G>T	ENST00000316157.3	-	14	1618	c.1578C>A	c.(1576-1578)agC>agA	p.S526R		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	526							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						CCAGCTCGAAGCTTGGCGACG	0.542000													50	136					1.19451e-25	1.26519e-25	1	1	0
FBXO44	93611	broad.mit.edu	37	1	11718437	11718437	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:11718437G>A	ENST00000376770.1	+	4	877	c.379G>A	c.(379-381)Gtt>Att	p.V127I	FBXO44_ENST00000376768.1_Intron|FBXO44_ENST00000376760.1_Intron|FBXO44_ENST00000376762.4_Intron|FBXO44_ENST00000251547.5_Missense_Mutation_p.V127I|FBXO44_ENST00000251546.4_Intron	NM_001014765.1	NP_001014765.1	Q9H4M3	FBX44_HUMAN	F-box protein 44	127	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GAAATACTTCGTTACTTCATA	0.532000													34	112					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26507049	26507049	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:26507049T>C	ENST00000244513.6	+	4	914	c.848T>C	c.(847-849)tTc>tCc	p.F283S		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	283						extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						AGGAATGAATTCAGCTCTAAA	0.448000													10	259					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98205478	98205478	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:98205478A>G	ENST00000284049.3	-	29	4236	c.4087T>C	c.(4087-4089)Tct>Cct	p.S1363P	CHD1_ENST00000511067.1_5'UTR	NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1363					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TCTTCATCAGACTTCTCTGAA	0.323000													3	52					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711055	41711055	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:41711055T>C	ENST00000400454.1	-	7	1975	c.1498A>G	c.(1498-1500)Aac>Gac	p.N500D		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	500	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCTCTTACGTTTATTCGAGCC	0.517000													20	52					0	0	1	0	0
STYX	6815	broad.mit.edu	37	14	53235559	53235559	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:53235559A>G	ENST00000354586.4	+	10	799	c.504_splice	c.e10-1	p.E169_splice	STYX_ENST00000556861.1_Intron|STYX_ENST00000442123.2_Splice_Site_p.E169_splice	NM_145251.3	NP_660294.1	Q8WUJ0	STYX_HUMAN	serine/threonine/tyrosine interacting protein	169					protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(41;0.176)					tttttttaGGAATATGAAGCC	0.303000													34	47					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46341722	46341722	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:46341722A>G	ENST00000245934.7	-	10	1483	c.1239T>C	c.(1237-1239)aaT>aaC	p.N413N		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	413					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		TCCTCACCAGATTAGCCACAT	0.597000													6	34					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42583151	42583151	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42583151C>T	ENST00000600245.1	+	2	1048	c.393C>T	c.(391-393)tgC>tgT	p.C131C	CTB-59C6.3_ENST00000594531.1_RNA|ZNF574_ENST00000222339.7_Silent_p.C221C|ZNF574_ENST00000359044.4_Silent_p.C131C			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				GTGTGGATTGCAAGGCTCTCT	0.632000													24	81					0	0	1	0	0
POLR2F	5435	broad.mit.edu	37	22	38349816	38349816	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:38349816T>C	ENST00000442738.2	+	1	145		c.e1+2		POLR2F_ENST00000407936.1_Splice_Site|POLR2F_ENST00000606538.1_Splice_Site|POLR2F_ENST00000405557.1_Splice_Site|POLR2F_ENST00000488684.1_Splice_Site|POLR2F_ENST00000484894.1_Intron|POLR2F_ENST00000470701.1_5'UTR|POLR2F_ENST00000460648.1_Splice_Site	NM_021974.3	NP_068809.1	P61218	RPAB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide F						mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)|urinary_tract(2)	3	Melanoma(58;0.045)					CGAGGACAAGTGAGTGCGGGA	0.667000													10	29					0	0	1	0	0
CAPRIN1	4076	broad.mit.edu	37	11	34074146	34074146	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:34074146T>C	ENST00000341394.4	+	2	368	c.179T>C	c.(178-180)gTg>gCg	p.V60A	CAPRIN1_ENST00000389645.3_Missense_Mutation_p.V60A|CAPRIN1_ENST00000530820.1_Missense_Mutation_p.V60A|CAPRIN1_ENST00000532820.1_Missense_Mutation_p.V60A	NM_005898.4	NP_005889.3	Q14444	CAPR1_HUMAN	cell cycle associated protein 1	60					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)	18		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				ATTCTCGGGGTGATCGACAAG	0.701000													9	19					0	0	1	0	0
TSC22D4	81628	broad.mit.edu	37	7	100065214	100065214	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100065214T>C	ENST00000300181.2	-	4	1693	c.939A>G	c.(937-939)ggA>ggG	p.G313G	TSC22D4_ENST00000393991.1_Silent_p.G74G|TSC22D4_ENST00000496728.1_5'UTR	NM_030935.3	NP_112197.1	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	313					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAACCAGGCTTCCGGAGCCAC	0.602000													19	68					0	0	1	0	0
MOGS	7841	broad.mit.edu	37	2	74689730	74689730	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:74689730T>C	ENST00000233616.4	-	4	1348	c.1186A>G	c.(1186-1188)Agc>Ggc	p.S396G	MOGS_ENST00000409065.1_3'UTR|MOGS_ENST00000452063.2_Missense_Mutation_p.S290G	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	396					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						AGGAGGCCGCTGAGGGCAGCC	0.582000													9	310					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155654227	155654227	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:155654227T>C	ENST00000496455.1	+	15	2243	c.1908T>C	c.(1906-1908)gtT>gtC	p.V636V	GMPS_ENST00000295920.7_Silent_p.V537V	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	636					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GATCTGTGGTTATTCGAACCT	0.418000			T	MLL	AML								19	150					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662998	99662998	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:99662998T>C	ENST00000373034.4	-	1	2273	c.598A>G	c.(598-600)Acg>Gcg	p.T200A	PCDH19_ENST00000255531.7_Missense_Mutation_p.T200A|PCDH19_ENST00000420881.2_Missense_Mutation_p.T200A	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	200	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						TGCGACTGCGTCTCGCGGTCC	0.637000													29	34					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48717525	48717525	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:48717525G>A	ENST00000294129.2	-	6	1349	c.1230C>T	c.(1228-1230)atC>atT	p.I410I	NCKIPSD_ENST00000416649.2_Silent_p.I403I|NCKIPSD_ENST00000341520.4_Silent_p.I410I	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	410					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTAGCAGCGGATGACACCCT	0.602000													37	65					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19628077	19628077	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:19628077T>C	ENST00000438132.3	+	14	1486	c.1438T>C	c.(1438-1440)Tac>Cac	p.Y480H	C16orf62_ENST00000448695.1_Missense_Mutation_p.Y241H|C16orf62_ENST00000417362.2_Intron|C16orf62_ENST00000251143.5_Missense_Mutation_p.Y391H|C16orf62_ENST00000542263.1_Intron|C16orf62_ENST00000543152.1_Missense_Mutation_p.Y140H	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	391						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						CCTCCCCTTGTACCCGCCTGC	0.552000													19	45					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145771072	145771072	+	Silent	SNP	G	G	A	rs139243141	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145771072G>A	ENST00000276826.5	-	5	2283	c.2082C>T	c.(2080-2082)atC>atT	p.I694I	ARHGAP39_ENST00000377307.2_Silent_p.I694I|ARHGAP39_ENST00000540274.1_Silent_p.I694I			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	694					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CCCAGTTCTCGATGTCCGTCT	0.642000													53	51					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33790497	33790497	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:33790497T>C	ENST00000257118.5	-	14	2599	c.2546A>G	c.(2545-2547)tAc>tGc	p.Y849C	PHC2_ENST00000419414.2_Missense_Mutation_p.Y850C|PHC2_ENST00000373422.3_Missense_Mutation_p.Y455C|PHC2_ENST00000431992.1_Missense_Mutation_p.Y820C|RP11-415J8.3_ENST00000588828.1_RNA|RP11-415J8.3_ENST00000587696.1_RNA|PHC2_ENST00000485928.1_5'UTR|RP11-415J8.3_ENST00000457957.2_RNA|PHC2_ENST00000373418.3_Missense_Mutation_p.Y314C	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	849	SAM.				multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GATGCGGGCGTAGATCTTCAG	0.627000													22	74					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77758181	77758181	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:77758181C>T	ENST00000310942.4	+	5	1043	c.939C>T	c.(937-939)agC>agT	p.S313S		NM_005189.2	NP_005180.1	Q14781	CBX2_HUMAN	chromobox homolog 2	313					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding	p.S313S(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AGGCCCCCAGCGGTGGGGCTG	0.677000													8	35					0	0	1	0	0
CDYL	9425	broad.mit.edu	37	6	4937972	4937972	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:4937972G>A	ENST00000328908.5	+	6	1414		c.e6+1		CDYL_ENST00000449732.2_Splice_Site|CDYL_ENST00000397588.3_Splice_Site|CDYL_ENST00000343762.5_Splice_Site|CDYL_ENST00000472453.1_Splice_Site			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like						regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		AAGCTATCAGGTATGTAAAAA	0.373000													18	47					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30107747	30107747	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:30107747A>G	ENST00000331968.5	-	6	1162	c.933T>C	c.(931-933)cgT>cgC	p.R311R	PRKD1_ENST00000415220.2_Silent_p.R319R|PRKD1_ENST00000551644.1_5'UTR	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	311					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCGGTGCACAACGTTTATGGC	0.373000													23	90					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49139697	49139697	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49139697A>G	ENST00000306125.6	-	7	909	c.570_splice	c.e7-1	p.V191_splice	QARS_ENST00000420147.2_Splice_Site_p.V209_splice|QARS_ENST00000470225.1_5'UTR|QARS_ENST00000414533.1_Splice_Site_p.V180_splice			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	191					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGCTTTTGCCACCTGAAAGAA	0.517000													103	330					0	0	1	0	0
FZD6	8323	broad.mit.edu	37	8	104341955	104341955	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:104341955A>G	ENST00000358755.4	+	6	1931	c.1614A>G	c.(1612-1614)aaA>aaG	p.K538K	FZD6_ENST00000523739.1_Silent_p.K506K|FZD6_ENST00000540287.1_Silent_p.K233K|FZD6_ENST00000522566.1_Silent_p.K538K	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	538					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			CTAAAGTTAAACACAAAAAGA	0.378000													13	66					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46659966	46659966	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:46659966T>C	ENST00000544460.1	+	1	4355	c.4101T>C	c.(4099-4101)aaT>aaC	p.N1367N	TDRD6_ENST00000316081.6_Silent_p.N1367N	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1367	Tudor 6.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			CAGAAGATAATTTATGGTATC	0.378000													88	209					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60503711	60503711	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:60503711T>C	ENST00000371201.3	-	6	923	c.816A>G	c.(814-816)gcA>gcG	p.A272A	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	272							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GGTCTGCAGCTGCTTTATTTT	0.388000													16	29					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62191955	62191955	+	Silent	SNP	G	G	A	rs141657913	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62191955G>A	ENST00000467148.1	-	16	7446	c.7377C>T	c.(7375-7377)caC>caT	p.H2459H	HELZ2_ENST00000427522.2_Silent_p.H1890H	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CCTTGCCAGCGTGGCCCAGGA	0.632000													43	116					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46929670	46929670	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46929670T>C	ENST00000262738.3	-	1	3397	c.3398A>G	c.(3397-3399)gAc>gGc	p.D1133G	CELSR1_ENST00000497509.1_5'UTR|CELSR1_ENST00000395964.1_Missense_Mutation_p.D1133G	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1133	Cadherin 9.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GTCTGACACGTCGGGGTCATG	0.622000													10	168					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17758091	17758091	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17758091G>A	ENST00000428389.2	-	18	2290	c.2291C>T	c.(2290-2292)gCc>gTc	p.A764V	UNC13A_ENST00000552293.1_Missense_Mutation_p.A676V|UNC13A_ENST00000519716.2_Missense_Mutation_p.A676V|UNC13A_ENST00000551649.1_Missense_Mutation_p.A676V|UNC13A_ENST00000252773.7_Missense_Mutation_p.A676V|UNC13A_ENST00000550896.1_Missense_Mutation_p.A674V			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	676	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GCTGATCTTGGCGGACCACTT	0.647000													6	9					0	0	1	0	0
EPHX4	253152	broad.mit.edu	37	1	92518158	92518158	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:92518158T>C	ENST00000370383.4	+	6	898	c.800T>C	c.(799-801)gTc>gCc	p.V267A		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	267						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TATATTTATGTCTTTTCTCAG	0.328000													11	23					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226446754	226446754	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:226446754C>T	ENST00000272907.6	+	4	1034	c.621C>T	c.(619-621)ttC>ttT	p.F207F	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	207																	GCACATCTTTCGATGAAACGT	0.567000													65	225					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71036435	71036435	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:71036435T>C	ENST00000272367.2	-	7	1814	c.1738A>G	c.(1738-1740)Acc>Gcc	p.T580A	CLEC4F_ENST00000426626.1_Intron	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	580	C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						CAGGGAGGGGTGTCTATGAAG	0.542000													16	30					0	0	1	0	0
PIK3R2	5296	broad.mit.edu	37	19	18279334	18279334	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:18279334G>T	ENST00000593731.1	+	14	2346	c.1786G>T	c.(1786-1788)Ggg>Tgg	p.G596W	PIK3R2_ENST00000222254.7_Missense_Mutation_p.G596W			O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	596					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(3)|pancreas(1)|stomach(1)	24						cgagtggctggggattaaaaa	0.572000											OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	24					5.18039e-06	5.29904e-06	1	1	0
ASH2L	9070	broad.mit.edu	37	8	37967961	37967961	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:37967961A>G	ENST00000343823.6	+	4	775	c.466A>G	c.(466-468)Acc>Gcc	p.T156A	ASH2L_ENST00000250635.7_Missense_Mutation_p.T62A|ASH2L_ENST00000545394.1_Missense_Mutation_p.T17A|ASH2L_ENST00000428278.2_Missense_Mutation_p.T62A|ASH2L_ENST00000521652.1_Missense_Mutation_p.T62A	NM_004674.4	NP_004665.2	Q9UBL3	ASH2L_HUMAN	ash2 (absent, small, or homeotic)-like (Drosophila)	156					hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)	19	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				CAGTGGGAATACCTATTTCCT	0.423000													21	81					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23453903	23453903	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:23453903T>C	ENST00000307149.5	-	4	684	c.499A>G	c.(499-501)Aca>Gca	p.T167A		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	167					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		TAGTCTGGTGTATCAACAAGC	0.443000													10	107					0	0	1	0	0
IRS2	8660	broad.mit.edu	37	13	110436629	110436629	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:110436629G>A	ENST00000375856.3	-	1	2286	c.1772C>T	c.(1771-1773)tCc>tTc	p.S591F		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	591					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			CGAGGCAGAGGAGGGCTGGGG	0.736000													8	24					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156957825	156957825	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:156957825G>A	ENST00000257527.4	-	5	475	c.397C>T	c.(397-399)Cga>Tga	p.R133*	ADAM19_ENST00000394020.1_Nonsense_Mutation_p.R135*|ADAM19_ENST00000517905.1_Nonsense_Mutation_p.R133*|ADAM19_ENST00000430702.2_5'UTR	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	133			R -> Q (in a colorectal cancer sample; somatic mutation).		proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTAATTCCTCGGCAAGTGCTG	0.557000													23	49					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160803891	160803891	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:160803891A>G	ENST00000368034.4	-	7	1087	c.910T>C	c.(910-912)Tca>Cca	p.S304P	CD244_ENST00000481677.1_5'UTR|CD244_ENST00000368033.3_Missense_Mutation_p.S309P|CD244_ENST00000322302.7_Missense_Mutation_p.S212P|CD244_ENST00000368032.2_Missense_Mutation_p.S304P	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	309					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GGTTCTTGTGACGTGGGAGCA	0.428000													11	58					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25715941	25715941	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25715941G>T	ENST00000520164.1	-	14	1959	c.1422C>A	c.(1420-1422)acC>acA	p.T474T	EBF2_ENST00000408929.3_Silent_p.T326T|EBF2_ENST00000535548.1_Silent_p.T205T	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	474	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TGTTGCTGGAGGTACTGTAAT	0.517000													9	135					0.000442599	0.000448264	1	1	0
KRT77	374454	broad.mit.edu	37	12	53097133	53097133	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:53097133C>T	ENST00000341809.3	-	1	114	c.86G>A	c.(85-87)gGt>gAt	p.G29D	KRT77_ENST00000537195.1_De_novo_Start_InFrame	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	29	Head.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CGGACTCCCACCACCAGAGCC	0.542000													20	73					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43173691	43173691	+	RNA	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:43173691A>T	ENST00000522175.2	+	0	977							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GTGATGGTGGATTAGTTCCAC	0.413000													13	154					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236881176	236881176	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:236881176A>G	ENST00000366578.4	+	2	311	c.145A>G	c.(145-147)Aac>Gac	p.N49D	ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000542672.1_Missense_Mutation_p.N49D	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	49	Actin-binding.|CH 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGCCTGGTGTAACTCCCACCT	0.493000													14	30					0	0	1	0	0
CHMP2B	25978	broad.mit.edu	37	3	87302561	87302561	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:87302561T>A	ENST00000263780.4	+	5	670	c.432T>A	c.(430-432)gaT>gaA	p.D144E	CHMP2B_ENST00000494980.1_Missense_Mutation_p.D114E|CHMP2B_ENST00000471660.1_Missense_Mutation_p.D103E|CHMP2B_ENST00000472024.1_3'UTR	NM_014043.3	NP_054762.2	Q9UQN3	CHM2B_HUMAN	charged multivesicular body protein 2B	144					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane|mitochondrion|nucleus	protein domain specific binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	12	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		TAGTCAATGATACACTTGATG	0.368000													14	40					0	0	1	0	0
VPS18	57617	broad.mit.edu	37	15	41195445	41195445	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:41195445A>T	ENST00000220509.5	+	5	3167	c.2828A>T	c.(2827-2829)gAg>gTg	p.E943V		NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	943					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GTGGCCGCTGAGTGTGTGTAC	0.657000													11	23					0	0	1	0	0
FAM84B	157638	broad.mit.edu	37	8	127569449	127569449	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:127569449A>G	ENST00000304916.3	-	2	641	c.186T>C	c.(184-186)ggT>ggC	p.G62G	RP11-103H7.5_ENST00000524320.1_RNA	NM_174911.4	NP_777571.1	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	62	Pro-rich.					cytoplasm|plasma membrane	protein binding			lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			GCCCGTCCCCACCGTCGGGCA	0.677000													8	25					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43690520	43690520	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:43690520A>G	ENST00000404580.1	-	1	126	c.38T>C	c.(37-39)aTc>aCc	p.I13T	PSG5_ENST00000401992.1_5'UTR|PSG5_ENST00000599812.1_Missense_Mutation_p.I13T|PSG5_ENST00000407356.1_Missense_Mutation_p.I13T|PSG5_ENST00000366175.3_Missense_Mutation_p.I13T|PSG5_ENST00000407568.1_Missense_Mutation_p.I13T|PSG5_ENST00000342951.6_Missense_Mutation_p.I13T			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	13					female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CTTCCAGGTGATGTGCTGTGT	0.597000													57	160					0	0	1	0	0
HOXC12	3228	broad.mit.edu	37	12	54348916	54348916	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:54348916A>G	ENST00000243103.3	+	1	299	c.203A>G	c.(202-204)tAc>tGc	p.Y68C		NM_173860.1	NP_776272.1	P31275	HXC12_HUMAN	homeobox C12	68					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	12						CCGCAGCCCTACCTCGGCAGC	0.701000													6	31					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80382759	80382759	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:80382759G>A	ENST00000265080.4	+	9	1444	c.1377G>A	c.(1375-1377)acG>acA	p.T459T	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	459					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CCAGCCAAACGTTCATCCGCC	0.537000													30	87					0	0	1	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013786	149013786	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:149013786A>G	ENST00000535454.1	+	4	1289	c.740A>G	c.(739-741)aAg>aGg	p.K247R	MAGEA8_ENST00000542674.1_Missense_Mutation_p.K247R|MAGEA8_ENST00000286482.1_Missense_Mutation_p.K247R	NM_001166400.1	NP_001159872.1	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	247	MAGE.									NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCTCAGGAAGCTGCTCACC	0.617000													4	128					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171146	150171146	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150171146G>A	ENST00000307271.3	+	4	1303	c.729G>A	c.(727-729)ccG>ccA	p.P243P		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	243						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AGCAGAATCCGGGGACATCAG	0.552000													56	129					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669627	234669627	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:234669627A>G	ENST00000360418.3	+	1	694	c.694A>G	c.(694-696)Acc>Gcc	p.T232A	UGT1A5_ENST00000373414.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A1_ENST00000305208.5_Missense_Mutation_p.T232A			P22309	UD11_HUMAN		232					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCCGTATGCAACCCTTGCCTC	0.483000													20	188					0	0	1	0	0
DDX3Y	8653	broad.mit.edu	37	Y	15016853	15016853	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrY:15016853T>C	ENST00000336079.3	+	1	112	c.6T>C	c.(4-6)agT>agC	p.S2S	DDX3Y_ENST00000360160.4_Silent_p.S2S	NM_001122665.1|NM_004660.3	NP_001116137.1|NP_004651.2	O15523	DDX3Y_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	2						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding			kidney(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	5						CAGGGATGAGTCATGTGGTGG	0.507000													31	26					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68179674	68179674	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:68179674A>G	ENST00000262215.3	-	11	1965	c.1576T>C	c.(1576-1578)Ttc>Ctc	p.F526L	ARFGEF1_ENST00000520381.1_5'UTR	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	526					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCTTTAAAGAACACCTGTGAT	0.333000													24	60					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40054250	40054250	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:40054250C>T	ENST00000336649.4	+	14	2104	c.2104C>T	c.(2104-2106)Ctc>Ttc	p.L702F	CACNA1I_ENST00000402142.3_Missense_Mutation_p.L696F|CACNA1I_ENST00000401624.1_Missense_Mutation_p.L696F|CACNA1I_ENST00000400164.3_Missense_Mutation_p.L661F|CACNA1I_ENST00000404898.1_Missense_Mutation_p.L661F|CACNA1I_ENST00000407673.1_Missense_Mutation_p.L661F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	696					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TGCATTTGGGCTCTTCGACTA	0.572000													32	86					0	0	1	0	0
VDR	7421	broad.mit.edu	37	12	48238538	48238538	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:48238538C>T	ENST00000229022.3	-	11	1556	c.1275G>A	c.(1273-1275)gaG>gaA	p.E425E	VDR_ENST00000549336.1_Silent_p.E425E|VDR_ENST00000535672.1_Silent_p.E393E|VDR_ENST00000550325.1_Silent_p.E475E|VDR_ENST00000395324.2_Silent_p.E425E	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	425	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GTCAGGAGATCTCATTGCCAA	0.637000													6	105					0	0	1	0	0
CD97	976	broad.mit.edu	37	19	14517264	14517264	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:14517264A>C	ENST00000242786.5	+	15	2023	c.1943A>C	c.(1942-1944)cAg>cCg	p.Q648P	CTC-548K16.5_ENST00000590626.1_RNA|CD97_ENST00000357355.3_Missense_Mutation_p.Q599P|CD97_ENST00000358600.3_Missense_Mutation_p.Q555P	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	648					cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TTCCAAGGCCAGGGCCTGAGT	0.652000											OREG0025312	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43378792	43378792	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:43378792T>C	ENST00000372861.3	+	2	437	c.306T>C	c.(304-306)ggT>ggC	p.G102G		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	102						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				CCGCGCCGGGTACGGACTCCG	0.682000													13	44					0	0	1	0	0
SNX13	23161	broad.mit.edu	37	7	17930068	17930068	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:17930068A>G	ENST00000409389.1	-	5	530	c.358T>C	c.(358-360)Tat>Cat	p.Y120H	SNX13_ENST00000428135.3_Missense_Mutation_p.Y120H|SNX13_ENST00000409604.1_Missense_Mutation_p.Y120H			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	120	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					AGTGTATAATACCAATACTGG	0.328000													17	61					0	0	1	0	0
RXRB	6257	broad.mit.edu	37	6	33168031	33168031	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:33168031C>T	ENST00000374680.3	-	1	434	c.223G>A	c.(223-225)Gac>Aac	p.D75N	RXRB_ENST00000544186.1_Intron|RXRB_ENST00000374685.4_Missense_Mutation_p.D75N|RXRB_ENST00000413614.2_Silent_p.A61A	NM_001270401.1|NM_021976.4	NP_001257330.1|NP_068811.1	P28702	RXRB_HUMAN	retinoid X receptor, beta	75	Modulating (By similarity).|Pro-rich.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(1)|skin(2)	15					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CGCCCGCTGTCGCCCATCCCG	0.716000													12	18					0	0	1	0	0
ZNF398	57541	broad.mit.edu	37	7	148876542	148876542	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:148876542G>A	ENST00000420008.2	+	6	1853	c.1065G>A	c.(1063-1065)ctG>ctA	p.L355L	ZNF398_ENST00000475153.1_Silent_p.L526L|ZNF398_ENST00000426851.2_Silent_p.L355L|ZNF398_ENST00000483892.1_Silent_p.L355L|ZNF398_ENST00000335901.4_Silent_p.L355L|ZNF398_ENST00000540950.1_Silent_p.L531L|ZNF398_ENST00000491174.1_Silent_p.L355L	NM_170686.2	NP_733787.1	Q8TD17	ZN398_HUMAN	zinc finger protein 398	526					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			AGGAGCACCTGCTGAACCACC	0.607000													36	111					0	0	1	0	0
CDR2	1039	broad.mit.edu	37	16	22385621	22385621	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:22385621C>T	ENST00000268383.2	-	1	317	c.10G>A	c.(10-12)Gaa>Aaa	p.E4K	CDR2_ENST00000569045.1_Intron	NM_001802.1	NP_001793.1	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2, 62kDa	4						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		ACCAGGTTTTCCGCCAGCATC	0.731000													38	97					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148431758	148431758	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:148431758A>G	ENST00000515425.1	-	2	199	c.98T>C	c.(97-99)aTa>aCa	p.I33T	SH3TC2_ENST00000394358.2_5'UTR|SH3TC2_ENST00000512049.1_Missense_Mutation_p.I33T	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	33							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATGAGGCTATACACTCACT	0.388000													4	172					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44467254	44467254	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:44467254A>G	ENST00000372310.3	-	9	1173	c.1008T>C	c.(1006-1008)taT>taC	p.Y336Y	SLC6A9_ENST00000372306.3_Silent_p.Y336Y|SLC6A9_ENST00000360584.2_Silent_p.Y409Y|SLC6A9_ENST00000475075.2_Silent_p.Y225Y|SLC6A9_ENST00000372307.3_Silent_p.Y271Y|SLC6A9_ENST00000537678.1_Silent_p.Y271Y|SLC6A9_ENST00000357730.2_Silent_p.Y355Y	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	409						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CGAAGCCAGCATAGACGCTGG	0.587000													6	290					0	0	1	0	0
TERF1	7013	broad.mit.edu	37	8	73937154	73937154	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:73937154A>G	ENST00000276602.6	+	5	745	c.722A>G	c.(721-723)aAg>aGg	p.K241R	TERF1_ENST00000276603.5_Missense_Mutation_p.K241R	NM_003218.3	NP_003209.2	P54274	TERF1_HUMAN	telomeric repeat binding factor (NIMA-interacting) 1	241	TRFH dimerization.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9	Breast(64;0.218)		Epithelial(68;0.0984)			GAGAAAATTAAGAGTTATGTG	0.303000													4	40					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52562241	52562241	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52562241G>A	ENST00000307076.4	-	6	1018	c.618C>T	c.(616-618)caC>caT	p.H206H	NT5DC2_ENST00000307092.4_Silent_p.H147H|NT5DC2_ENST00000422318.2_Silent_p.H243H|NT5DC2_ENST00000459839.1_Silent_p.H218H	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	206							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		ACTCCAGGCTGTGGCCCAGAA	0.587000													30	78					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945255	119945255	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:119945255G>A	ENST00000297350.4	-	2	693	c.315C>T	c.(313-315)tgC>tgT	p.C105C		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	105					apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CCTTGCATTCGCACACGCGGT	0.552000													19	70					0	0	1	0	0
ZNF879	345462	broad.mit.edu	37	5	178454545	178454545	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:178454545G>A	ENST00000519896.1	+	3	275	c.139G>A	c.(139-141)Gag>Aag	p.E47K	ZNF879_ENST00000444149.2_Silent_p.Q35Q			B4DU55	ZN879_HUMAN	zinc finger protein 879	184	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|pancreas(1)|stomach(1)	7						ACTCTGCCCAGAGAGCCTTGT	0.562000													18	30					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84531732	84531732	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:84531732T>C	ENST00000527857.1	+	0	1754					NR_026851.1																						TGCCCAGAGGTCAGTCCCCAC	0.517000													18	52					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339883	55339883	+	Missense_Mutation	SNP	G	G	A	rs150706012	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:55339883G>A	ENST00000314634.3	+	1	280	c.280G>A	c.(280-282)Gag>Aag	p.E94K		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E94K(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				CTCCTTCAGCGAGTGCATGAT	0.458000													48	209					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143425546	143425546	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:143425546A>G	ENST00000524325.1	-	4	701	c.526T>C	c.(526-528)Tac>Cac	p.Y176H	TSNARE1_ENST00000519651.1_Intron|TSNARE1_ENST00000520166.1_Missense_Mutation_p.Y176H|TSNARE1_ENST00000307180.3_Missense_Mutation_p.Y176H			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	176					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGGCGACAGTAGCCCAGCGCA	0.692000													16	149					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52672031	52672031	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:52672031C>T	ENST00000399231.3	-	17	2330	c.2087G>A	c.(2086-2088)gGt>gAt	p.G696D	MYO5A_ENST00000553916.1_Missense_Mutation_p.G696D|MYO5A_ENST00000356338.6_Missense_Mutation_p.G696D|MYO5A_ENST00000399233.2_Missense_Mutation_p.G696D|MYO5A_ENST00000358212.6_Missense_Mutation_p.G696D	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	696	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TGAGGGGAAACCGGCCGCACT	0.448000													18	136					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113673937	113673937	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:113673937C>T	ENST00000003302.4	-	23	2873	c.2805G>A	c.(2803-2805)ggG>ggA	p.G935G	USP28_ENST00000545540.1_Silent_p.G778G|USP28_ENST00000260188.5_Silent_p.G903G|USP28_ENST00000544967.1_Silent_p.G611G	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	935					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CCCGGCGGGGCCCCTTCATCA	0.458000													7	144					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90346715	90346715	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:90346715G>T	ENST00000300060.6	-	9	1774	c.1461C>A	c.(1459-1461)ctC>ctA	p.L487L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	487	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ggaagctGGAGAGCATCCTGA	0.667000													6	11					5.9392e-07	6.09457e-07	1	1	0
CDC42BPG	55561	broad.mit.edu	37	11	64599131	64599131	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64599131G>A	ENST00000342711.5	-	28	3149	c.3150C>T	c.(3148-3150)agC>agT	p.S1050S	CDC42BPG_ENST00000491280.1_5'UTR	NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1050	PH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCTCCCCCTCGCTCTCTGCCA	0.697000											OREG0004016	type=REGULATORY REGION|Gene=CDC42BPG|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	16					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41798870	41798870	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:41798870A>G	ENST00000396930.3	-	16	3072	c.2529T>C	c.(2527-2529)tcT>tcC	p.S843S	KAT6A_ENST00000406337.1_Silent_p.S843S|KAT6A_ENST00000265713.2_Silent_p.S843S	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	843					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCAAACGTGTAGAACTGACTG	0.453000													23	77					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120594296	120594296	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120594296G>A	ENST00000300648.6	-	28	3293	c.3281C>T	c.(3280-3282)cCg>cTg	p.P1094L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1094					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGGCACACGGGGACTGCAA	0.597000													5	85					0	0	1	0	0
ARHGAP1	392	broad.mit.edu	37	11	46700995	46700995	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:46700995G>A	ENST00000311956.4	-	12	1148	c.1051C>T	c.(1051-1053)Cca>Tca	p.P351S		NM_004308.2	NP_004299.1	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	351	Rho-GAP.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		AGTGTCGCTGGCACCCTCTGG	0.597000													23	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073349	9073349	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9073349T>C	ENST00000397910.4	-	3	14300	c.14097A>G	c.(14095-14097)tcA>tcG	p.S4699S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4701	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTCCAAGGTTGATGTGTCTA	0.478000													19	207					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625709	111625709	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:111625709C>T	ENST00000333999.3	+	1	1107	c.1107C>T	c.(1105-1107)ggC>ggT	p.G369G		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	369						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TGCTCAGTGGCTTCCCTAACC	0.582000													6	105					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67058494	67058494	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:67058494T>C	ENST00000295568.4	+	4	1544	c.1413T>C	c.(1411-1413)ttT>ttC	p.F471F	KBTBD8_ENST00000460576.1_Silent_p.F55F|KBTBD8_ENST00000417314.2_Silent_p.F497F	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	497										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AACGTATGTTTACTGTAGAAG	0.403000													16	115					0	0	1	0	0
MT1A	4489	broad.mit.edu	37	16	56672672	56672672	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:56672672G>A	ENST00000290705.8	+	1	95	c.22G>A	c.(22-24)Gcc>Acc	p.A8T		NM_005946.2	NP_005937.2	P04731	MT1A_HUMAN	metallothionein 1A	8	Beta.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(1)	3						CTGCTCCTGCGCCACTGGTAA	0.537000													39	143					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15935734	15935734	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:15935734G>A	ENST00000268712.3	-	46	7456	c.7199C>T	c.(7198-7200)cCg>cTg	p.P2400L	NCOR1_ENST00000395851.1_Missense_Mutation_p.P2297L|NCOR1_ENST00000395857.3_Missense_Mutation_p.P984L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2400	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ACATGCAATCGGTGTTGGTGG	0.507000													4	136					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14763990	14763990	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:14763990G>A	ENST00000358984.4	+	7	1306	c.1126G>A	c.(1126-1128)Gca>Aca	p.A376T	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Missense_Mutation_p.A376T	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	376										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGAATGCGTGGCAGGAGTAAC	0.353000													7	26					0	0	1	0	0
STRN3	29966	broad.mit.edu	37	14	31420119	31420119	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:31420119T>C	ENST00000355683.5	-	4	707	c.492A>G	c.(490-492)gcA>gcG	p.A164A	STRN3_ENST00000357479.5_Silent_p.A164A	NM_014574.3	NP_055389.3	Q13033	STRN3_HUMAN	striatin, calmodulin binding protein 3	164					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TATTCTGAGGTGCTGTGGGAG	0.348000													24	91					0	0	1	0	0
H2AFY	9555	broad.mit.edu	37	5	134705782	134705782	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:134705782G>A	ENST00000511689.1	-	3	816	c.223C>T	c.(223-225)Cgg>Tgg	p.R75W	H2AFY_ENST00000423969.2_Intron|H2AFY_ENST00000510038.1_Missense_Mutation_p.R75W|H2AFY_ENST00000304332.4_Missense_Mutation_p.R75W|H2AFY_ENST00000312469.4_Missense_Mutation_p.R75W	NM_001040158.1|NM_138610.2	NP_001035248.1|NP_613258.2	O75367	H2AY_HUMAN	H2A histone family, member Y	75	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGTGACCCGTCCCTTCTTG	0.562000													8	28					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30797914	30797914	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:30797914G>T	ENST00000375749.3	+	2	227	c.165G>T	c.(163-165)ctG>ctT	p.L55L	POFUT1_ENST00000375730.3_Silent_p.L55L|POFUT1_ENST00000539210.1_Intron|POFUT1_ENST00000486717.1_Intron	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	55					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGGGCTCTCTGGCATTTGCAA	0.552000													50	154					1.07234e-20	1.13075e-20	1	1	0
ZNF761	388561	broad.mit.edu	37	19	53945669	53945669	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53945669G>A	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AGACAAATGTGAGGAAGAGAT	0.448000													29	66					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39617741	39617741	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:39617741G>A	ENST00000262039.4	+	17	2011	c.1925G>A	c.(1924-1926)cGt>cAt	p.R642H	PIK3C3_ENST00000587402.1_5'UTR|PIK3C3_ENST00000593098.1_Missense_Mutation_p.R127H|PIK3C3_ENST00000589056.1_5'UTR|PIK3C3_ENST00000398870.3_Missense_Mutation_p.R579H	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	642	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						GATGATTTACGTCAAGATCAA	0.368000										TSP Lung(28;0.18)			53	169					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648188	112648188	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:112648188A>G	ENST00000471858.1	-	3	532	c.300T>C	c.(298-300)tgT>tgC	p.C100C	CD200R1_ENST00000490004.1_Silent_p.C100C|CD200R1_ENST00000295863.4_Silent_p.C78C|CD200R1_ENST00000308611.3_Silent_p.C123C|CD200R1_ENST00000440122.2_Silent_p.C123C	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	100	Ig-like V-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TCTCATCAGTACAGTTGGTTT	0.433000													37	101					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50918137	50918137	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:50918137C>A	ENST00000442544.2	+	17	3184	c.2568C>A	c.(2566-2568)acC>acA	p.T856T	DCC_ENST00000581580.1_Silent_p.T491T|DCC_ENST00000412726.1_Silent_p.T684T	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	856	Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGGCTCTTACCCATGATGCTG	0.527000													35	121					3.21399e-22	3.39778e-22	1	1	0
SLC18A3	6572	broad.mit.edu	37	10	50819857	50819857	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:50819857G>T	ENST00000374115.3	+	1	1511	c.1071G>T	c.(1069-1071)tgG>tgT	p.W357C	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	357					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						ACCTGCAGTGGCTGTACGGCG	0.692000													37	108					2.19358e-23	2.3201e-23	1	1	0
DPP9	91039	broad.mit.edu	37	19	4683620	4683620	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:4683620G>T	ENST00000262960.9	-	19	2477	c.2200C>A	c.(2200-2202)Cag>Aag	p.Q734K	DPP9_ENST00000598800.1_Missense_Mutation_p.Q705K|AC005594.3_ENST00000381796.1_RNA|DPP9_ENST00000601173.1_5'UTR|DPP9_ENST00000594671.1_Missense_Mutation_p.Q705K	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	705					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CCCTCCACCTGGTCCTCGATC	0.627000													4	110					0.150653	0.150988	1	1	0
TOX	9760	broad.mit.edu	37	8	59851965	59851965	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:59851965T>C	ENST00000361421.1	-	3	527	c.307A>G	c.(307-309)Aat>Gat	p.N103D		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	103						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				AGCAGGCCATTATGGTTCATG	0.483000													24	120					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23156368	23156368	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:23156368C>T	ENST00000389131.3	-	13	2595	c.2226G>A	c.(2224-2226)tgG>tgA	p.W742*		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	742	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		AGTTGTACATCCAGATGCGGT	0.542000													21	141					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74360281	74360281	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:74360281T>C	ENST00000377044.4	-	4	1226	c.687A>G	c.(685-687)acA>acG	p.T229T	TMEM2_ENST00000377066.5_Silent_p.T229T	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	229	G8.					integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GTAACTCCAGTGTCCCGCCAG	0.473000													7	124					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346399	89346399	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:89346399G>A	ENST00000301030.4	-	9	7011	c.6551C>T	c.(6550-6552)gCt>gTt	p.A2184V	ANKRD11_ENST00000378330.2_Missense_Mutation_p.A2184V	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2184	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGGCTCCTCAGCCACTACGGT	0.647000													10	55					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486951	125486951	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:125486951G>T	ENST00000259466.1	+	1	683	c.683G>T	c.(682-684)aGa>aTa	p.R228I		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						ACTGTGCTCAGAATCCCCTCT	0.517000													57	408					8.72158e-25	9.23113e-25	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72828213	72828213	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:72828213T>C	ENST00000268489.5	-	9	9040	c.8368A>G	c.(8368-8370)Aaa>Gaa	p.K2790E	ZFHX3_ENST00000397992.5_Missense_Mutation_p.K1876E	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2790					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TCCATGGTTTTACTCACAGGT	0.483000													9	118					0	0	1	0	0
XPNPEP1	7511	broad.mit.edu	37	10	111647813	111647813	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:111647813A>G	ENST00000502935.1	-	7	765	c.646T>C	c.(646-648)Tac>Cac	p.Y216H	XPNPEP1_ENST00000369683.1_Missense_Mutation_p.Y102H|XPNPEP1_ENST00000322238.8_Missense_Mutation_p.Y216H|XPNPEP1_ENST00000369680.4_Missense_Mutation_p.Y173H|XPNPEP1_ENST00000430337.1_5'UTR			Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	173					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			endometrium(2)|kidney(9)|large_intestine(4)|lung(9)|ovary(3)|pancreas(2)|skin(1)|urinary_tract(1)	31		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		TGACCTGTGTAATCCAGGCCC	0.572000													4	44					0	0	1	0	0
EZH2	2146	broad.mit.edu	37	7	148515124	148515124	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:148515124C>T	ENST00000320356.2	-	10	1206	c.1085G>A	c.(1084-1086)cGg>cAg	p.R362Q	EZH2_ENST00000476773.1_Missense_Mutation_p.R348Q|EZH2_ENST00000460911.1_Missense_Mutation_p.R357Q|EZH2_ENST00000350995.2_Missense_Mutation_p.R318Q|EZH2_ENST00000541220.1_Missense_Mutation_p.R348Q|EZH2_ENST00000483967.1_Missense_Mutation_p.R348Q|EZH2_ENST00000478654.1_Missense_Mutation_p.R348Q	NM_001203247.1|NM_001203248.1|NM_004456.4	NP_001190176.1|NP_001190177.1|NP_004447.2	Q15910	EZH2_HUMAN	enhancer of zeste homolog 2 (Drosophila)	357					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(313)|kidney(3)|large_intestine(8)|liver(1)|lung(23)|parathyroid(2)|skin(3)|upper_aerodigestive_tract(3)	359	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			ATTGGGAAGCCGTCCTCTTCT	0.537000			Mis		DLBCL								4	137					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577514	7577514	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:7577514G>A	ENST00000420246.2	-	7	899	c.767C>T	c.(766-768)aCa>aTa	p.T256I	TP53_ENST00000359597.4_Missense_Mutation_p.T256I|TP53_ENST00000455263.2_Missense_Mutation_p.T256I|TP53_ENST00000445888.2_Missense_Mutation_p.T256I|TP53_ENST00000269305.4_Missense_Mutation_p.T256I|TP53_ENST00000413465.2_Missense_Mutation_p.T256I	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	256	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		T -> I (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).|T -> P (in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.T256I(2)|p.T256K(2)|p.?(1)|p.T256fs*8(1)|p.I254fs*7(1)|p.T256fs*90(1)|p.T256fs*89(1)|p.T256del(1)|p.R249_T256delRPILTIIT(1)|p.T256fs*87(1)|p.I254_T256del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCTTCCAGTGTGATGATGGT	0.592000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	55					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18703432	18703432	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:18703432A>G	ENST00000251296.1	+	8	1623	c.1240A>G	c.(1240-1242)Acc>Gcc	p.T414A		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	414	Ig-like 2.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GTATCGCTGCACCGCCCAGAA	0.662000													7	50					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224824585	224824585	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:224824585A>G	ENST00000258383.3	+	2	583	c.514A>G	c.(514-516)Aac>Gac	p.N172D		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	172	RNase III.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		CGTGGCTAGAAACTTGGCTGT	0.473000													16	199					0	0	1	0	0
SLMAP	7871	broad.mit.edu	37	3	57850536	57850536	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:57850536C>T	ENST00000383718.3	+	11	1236	c.1138C>T	c.(1138-1140)Cgg>Tgg	p.R380W	SLMAP_ENST00000416870.1_Intron|SLMAP_ENST00000449503.2_Intron|SLMAP_ENST00000295951.3_Intron|SLMAP_ENST00000295952.3_Intron|SLMAP_ENST00000428312.1_Missense_Mutation_p.R380W			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	380					muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		ATTTACAGTACGGTTAGAACA	0.289000													10	25					0	0	1	0	0
PTPN18	26469	broad.mit.edu	37	2	131129859	131129859	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:131129859A>G	ENST00000175756.5	+	13	1144	c.1043A>G	c.(1042-1044)cAc>cGc	p.H348R	PTPN18_ENST00000347849.3_Missense_Mutation_p.H241R	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	348						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					TCCCCGGGCCACGCCATGGCT	0.756000													3	20					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18892440	18892440	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:18892440A>G	ENST00000380548.4	+	26	5036	c.4697A>G	c.(4696-4698)cAg>cGg	p.Q1566R	ADAMTSL1_ENST00000380545.5_Missense_Mutation_p.Q267R	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1566	TSP type-1 8.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GGAGGTGTCCAGACCCGCAGG	0.617000													3	21					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38655419	38655419	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:38655419C>T	ENST00000222345.6	+	15	4590	c.4081C>T	c.(4081-4083)Cgg>Tgg	p.R1361W		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1361					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGACAGGCGGCGGGAGGTCTC	0.721000													8	32					0	0	1	0	0
EIF2B2	8892	broad.mit.edu	37	14	75475775	75475775	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:75475775G>A	ENST00000266126.5	+	8	1020	c.940G>A	c.(940-942)Gac>Aac	p.D314N		NM_014239.3	NP_055054.1	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	314					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(234;0.00661)		CCCTGTGTTTGACTACGTTCC	0.483000													88	229					0	0	1	0	0
PCGF1	84759	broad.mit.edu	37	2	74733873	74733873	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:74733873G>T	ENST00000233630.6	-	3	1249	c.338C>A	c.(337-339)cCt>cAt	p.P113H	PCGF1_ENST00000480844.2_5'UTR	NM_032673.2	NP_116062.2	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1	113	Necessary for repressor activity.|No repressor activity.				histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(2)	12						TTGCAAGCCAGGCACCAGCTT	0.532000													26	74					3.28513e-13	3.42641e-13	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72828177	72828177	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:72828177G>T	ENST00000268489.5	-	9	9076	c.8404C>A	c.(8404-8406)Cct>Act	p.P2802T	ZFHX3_ENST00000397992.5_Missense_Mutation_p.P1888T	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2802					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ATGGAGGAAGGGCTTAGAAGA	0.478000													7	123					0.0293803	0.0295309	1	1	0
IL23R	149233	broad.mit.edu	37	1	67635261	67635261	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:67635261G>A	ENST00000347310.5	+	3	478	c.307G>A	c.(307-309)Gct>Act	p.A103T	C1orf141_ENST00000371007.2_Intron|IL23R_ENST00000371002.1_Missense_Mutation_p.A103T	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	103					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						GTACTGCACTGCTGAATGTCC	0.373000													9	128					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256700	140256700	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140256700A>G	ENST00000398631.2	+	1	1643	c.1643A>G	c.(1642-1644)aAc>aGc	p.N548S	PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGGCAGCAACGTGACGCTG	0.682000													79	252					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13098206	13098206	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:13098206A>G	ENST00000399002.2	+	8	1260	c.986A>G	c.(985-987)tAc>tGc	p.Y329C	SPTLC3_ENST00000378194.4_Intron	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	329					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	AAGAAGAAATACAAGGCTTAC	0.502000													58	184					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42554538	42554538	+	Nonsense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:42554538A>T	ENST00000381668.5	-	17	1734	c.1503T>A	c.(1501-1503)taT>taA	p.Y501*	ATP8A1_ENST00000264449.10_Nonsense_Mutation_p.Y486*	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	501					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	ATGCTGCTTGATAAATAATCT	0.348000													5	60					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43738703	43738703	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43738703C>T	ENST00000263801.3	-	14	3159	c.2907G>A	c.(2905-2907)ggG>ggA	p.G969G	TP53BP1_ENST00000382044.4_Silent_p.G974G|TP53BP1_ENST00000382039.3_Silent_p.G974G|TP53BP1_ENST00000450115.2_Silent_p.G974G	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	969					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CTTTTCCACTCCCAAGTATGG	0.468000								Other conserved DNA damage response genes					15	144					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33697065	33697065	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:33697065T>C	ENST00000253193.7	+	5	1591	c.1389T>C	c.(1387-1389)ggT>ggC	p.G463G		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	463	LDL-receptor class A 4.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					TCCACTGCGGTACCAACCTGT	0.657000													7	21					0	0	1	0	0
FZD4	8322	broad.mit.edu	37	11	86662997	86662997	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:86662997A>G	ENST00000531380.1	-	2	1106	c.801T>C	c.(799-801)atT>atC	p.I267I	PRSS23_ENST00000533902.2_3'UTR	NM_012193.3	NP_036325.2	Q9ULV1	FZD4_HUMAN	frizzled family receptor 4	267					canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(6)|skin(1)	21		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAATATAAGCAATGCTATAAA	0.438000													12	27					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114174334	114174334	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:114174334G>A	ENST00000259335.4	-	22	2707	c.2708C>T	c.(2707-2709)tCa>tTa	p.S903L	KIAA0368_ENST00000338205.5_Missense_Mutation_p.S725L	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						TTCTATCATTGATTTCAACTC	0.358000													3	21					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39047852	39047852	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:39047852A>G	ENST00000331366.5	-	20	1623	c.1527T>C	c.(1525-1527)taT>taC	p.Y509Y	CPNE8_ENST00000360449.3_Silent_p.Y497Y|CPNE8_ENST00000538596.2_Silent_p.Y178Y|CPNE8_ENST00000546603.1_5'UTR	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	509	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				TTCTGTCAATATAATCCCTGA	0.403000													3	53					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13222506	13222506	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:13222506T>C	ENST00000378694.1	+	6	904	c.829T>C	c.(829-831)Tct>Cct	p.S277P	MCM10_ENST00000484800.2_Missense_Mutation_p.S278P|MCM10_ENST00000378714.3_Missense_Mutation_p.S277P			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	278					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						GATCAGACTGTCTCAGATCAA	0.438000													41	113					0	0	1	0	0
JAM2	58494	broad.mit.edu	37	21	27078352	27078352	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:27078352T>C	ENST00000480456.1	+	7	1309	c.759T>C	c.(757-759)gtT>gtC	p.V253V	JAM2_ENST00000400532.1_Silent_p.V253V|JAM2_ENST00000312957.5_Silent_p.V253V|JAM2_ENST00000425221.2_Silent_p.V217V	NM_001270407.1|NM_021219.3	NP_001257336.1|NP_067042.1	P57087	JAM2_HUMAN	junctional adhesion molecule 2	253					blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|urinary_tract(1)	19						TGATTTCCGTTTGTGGCCTTG	0.388000													21	62					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100038070	100038070	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:100038070T>C	ENST00000258428.3	-	11	1950	c.1722A>G	c.(1720-1722)gtA>gtG	p.V574V	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Silent_p.V573V	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	574	UmuC.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CGGTAATGTCTACCAGCGCTT	0.453000								Direct reversal of damage					25	81					0	0	1	0	0
HNRNPUL2	221092	broad.mit.edu	37	11	62490360	62490360	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:62490360G>A	ENST00000301785.5	-	5	1099	c.907C>T	c.(907-909)Cca>Tca	p.P303S	RP11-831H9.16_ENST00000403734.2_Missense_Mutation_p.P303S	NM_001079559.2	NP_001073027.1	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 2	303	B30.2/SPRY.				cell killing	nucleus	ATP binding|nucleic acid binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCTTTCATTGGGAGATTCTGG	0.428000													15	41					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77944601	77944601	+	Missense_Mutation	SNP	C	C	A	rs140615876	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:77944601C>A	ENST00000493585.1	-	5	858	c.836G>T	c.(835-837)cGg>cTg	p.R279L	ISM2_ENST00000393684.3_Silent_p.T306T|ISM2_ENST00000412904.1_Silent_p.T313T|ISM2_ENST00000429906.1_Silent_p.T313T|ISM2_ENST00000342219.4_Silent_p.T394T	NM_182509.3	NP_872315.2	Q6H9L7	ISM2_HUMAN	isthmin 2	0						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						CATGCATGTCCGTAGCATTGC	0.607000													5	302					0.0215528	0.0216729	1	1	0
PTGS2	5743	broad.mit.edu	37	1	186648239	186648239	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:186648239C>T	ENST00000367468.5	-	3	400	c.264G>A	c.(262-264)gtG>gtA	p.V88V	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	88					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GAATGTTATTCACAACGTTCC	0.353000													12	51					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101749621	101749621	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:101749621G>A	ENST00000375001.3	+	4	1117	c.694G>A	c.(694-696)Gag>Aag	p.E232K		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	232	Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CAGGACTCCCGAGGAGCTGTG	0.647000													55	170					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54793706	54793706	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:54793706T>A	ENST00000293379.4	-	26	2930	c.2669A>T	c.(2668-2670)cAc>cTc	p.H890L	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	890					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						TTTTTGCTGGTGGTGCAGGGA	0.537000											OREG0021897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	219					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171405176	171405176	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:171405176T>C	ENST00000356327.5	-	15	1808	c.1738A>G	c.(1738-1740)Att>Gtt	p.I580V	PLD1_ENST00000351298.4_Missense_Mutation_p.I580V|PLD1_ENST00000342215.6_Intron|PLD1_ENST00000340989.4_Missense_Mutation_p.I580V	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	580	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GTGCTGTCAATGCTGCTGATG	0.433000													27	68					0	0	1	0	0
PLA2G5	5322	broad.mit.edu	37	1	20417069	20417069	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:20417069C>A	ENST00000375108.3	+	5	569	c.301C>A	c.(301-303)Ccc>Acc	p.P101T	PLA2G5_ENST00000486277.1_3'UTR	NM_000929.2	NP_000920.1	P39877	PA2G5_HUMAN	phospholipase A2, group V	101					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			NS(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		AGAGCCCGGGCCCTTCTGCCA	0.552000													6	153					0.0215528	0.0216729	1	1	0
GLDC	2731	broad.mit.edu	37	9	6588634	6588634	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:6588634T>C	ENST00000321612.6	-	13	1799	c.1649A>G	c.(1648-1650)cAc>cGc	p.H550R		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	550					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AATCATGCTGTGAACAAGGGA	0.433000													18	42					0	0	1	0	0
FBXO25	26260	broad.mit.edu	37	8	385615	385615	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:385615A>G	ENST00000352684.2	+	4	505	c.87_splice	c.e4-1	p.R30_splice	FBXO25_ENST00000276326.5_Splice_Site_p.R97_splice|FBXO25_ENST00000350302.3_Splice_Site_p.R97_splice|FBXO25_ENST00000382824.1_Splice_Site_p.R30_splice	NM_012173.3	NP_036305.2	Q8TCJ0	FBX25_HUMAN	F-box protein 25	97	Interaction with beta-actin.					nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		GCTTTTCCAGAGGCATGGCTA	0.358000													5	93					0	0	1	0	0
TMEM80	283232	broad.mit.edu	37	11	700633	700633	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:700633C>A	ENST00000397512.3	+	4	313	c.203C>A	c.(202-204)cCt>cAt	p.P68H	TMEM80_ENST00000397510.2_Missense_Mutation_p.P76H	NM_001042463.1|NM_174940.2	NP_001035928.1|NP_777600.2	Q96HE8	TMM80_HUMAN	transmembrane protein 80	76						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	5		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTCAGCTATCCTCACCGCTAC	0.517000													155	437					1.57643e-78	1.67363e-78	1	1	0
TENM2	57451	broad.mit.edu	37	5	167671662	167671662	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:167671662C>T	ENST00000519204.1	+	25	5513	c.5395C>T	c.(5395-5397)Cgc>Tgc	p.R1799C	TENM2_ENST00000520394.1_Missense_Mutation_p.R1681C|TENM2_ENST00000403607.2_Missense_Mutation_p.R1744C|TENM2_ENST00000518659.1_Missense_Mutation_p.R1920C|TENM2_ENST00000545108.1_Missense_Mutation_p.R1919C					teneurin transmembrane protein 2																		CAAGCAAGGCCGCATCGTGTC	0.577000													20	78					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94039109	94039109	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:94039109C>T	ENST00000553484.1	+	16	2171	c.2017C>T	c.(2017-2019)Cgg>Tgg	p.R673W	UNC79_ENST00000555664.1_Missense_Mutation_p.R673W|UNC79_ENST00000256339.4_Missense_Mutation_p.R496W|UNC79_ENST00000393151.2_Missense_Mutation_p.R673W			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	673						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TATTAGTTGTCGGTTTACAGG	0.393000													4	163					0	0	1	0	0
ZC3H14	79882	broad.mit.edu	37	14	89037460	89037460	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:89037460T>C	ENST00000251038.5	+	4	452	c.227T>C	c.(226-228)gTt>gCt	p.V76A	ZC3H14_ENST00000557607.1_5'UTR|ZC3H14_ENST00000555755.1_Missense_Mutation_p.V76A|ZC3H14_ENST00000336693.4_Missense_Mutation_p.V42A|ZC3H14_ENST00000556945.1_Missense_Mutation_p.V76A|ZC3H14_ENST00000393514.5_Missense_Mutation_p.V76A|ZC3H14_ENST00000359301.3_Missense_Mutation_p.V42A|ZC3H14_ENST00000302216.8_Missense_Mutation_p.V76A	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	76						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						CTTCGCTCTGTTACAACTGGT	0.313000													14	32					0	0	1	0	0
MRPS15	64960	broad.mit.edu	37	1	36926325	36926325	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:36926325T>C	ENST00000373116.5	-	5	514	c.353A>G	c.(352-354)aAc>aGc	p.N118S		NM_031280.3	NP_112570.2	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15	118					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)	14		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTCCTCTGGGTTTGCAACAAT	0.517000													6	84					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29649501	29649501	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:29649501T>C	ENST00000318184.5	-	2	170	c.171A>G	c.(169-171)ggA>ggG	p.G57G		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	57	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GCCATGGATGTCCAGTCACTG	0.393000													23	77					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30569889	30569889	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30569889C>T	ENST00000376511.2	-	19	3089	c.2537G>A	c.(2536-2538)cGt>cAt	p.R846H		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	846	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TTCATGGGGACGATGTCCACC	0.672000													40	123					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113933601	113933601	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:113933601A>G	ENST00000348367.4	-	7	613	c.416T>C	c.(415-417)gTa>gCa	p.V139A	GPAM_ENST00000423155.1_Missense_Mutation_p.V139A|GPAM_ENST00000369425.1_Missense_Mutation_p.V139A			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	139					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TGCCTCTTGTACTCTGGTATG	0.358000													15	54					0	0	1	0	0
APCDD1L	164284	broad.mit.edu	37	20	57036286	57036286	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:57036286T>C	ENST00000371149.3	-	4	1296	c.1066A>G	c.(1066-1068)Aca>Gca	p.T356A	APCDD1L_ENST00000491015.1_5'UTR|APCDD1L_ENST00000439429.1_Missense_Mutation_p.T367A	NM_153360.1	NP_699191.1	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated 1-like	356						integral to membrane				large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(1)	18	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			TGGGCCCGTGTGACCTCAAAC	0.687000													4	66					0	0	1	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679168	37679168	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:37679168T>C	ENST00000379800.3	-	1	635	c.226A>G	c.(226-228)Atg>Gtg	p.M76V		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	76	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity	p.M76V(1)		NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		TACCAGTGCATGTGGGGGATG	0.493000													32	110					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50280302	50280302	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:50280302C>T	ENST00000216268.4	+	2	3469	c.2992C>T	c.(2992-2994)Cac>Tac	p.H998Y		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	998						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TGCCACCCTCCACGACCCGCG	0.597000													6	27					0	0	1	0	0
MIPEP	4285	broad.mit.edu	37	13	24444256	24444256	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:24444256T>C	ENST00000382172.3	-	6	780	c.682A>G	c.(682-684)Aag>Gag	p.K228E		NM_005932.3	NP_005923.2	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase	228					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(12)|prostate(2)|skin(1)	27		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		TTCTCAATCTTGTTGGGAAAA	0.403000													7	102					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150529726	150529726	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:150529726G>A	ENST00000271643.4	+	12	2198	c.1962G>A	c.(1960-1962)ccG>ccA	p.P654P	ADAMTSL4_ENST00000369041.5_Silent_p.P654P|ADAMTSL4_ENST00000369038.2_Silent_p.P654P|RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369039.5_Silent_p.P677P	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	654	Pro-rich.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGCCCGCCCCGCCCCATCCCA	0.672000													3	23					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135771891	135771891	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:135771891T>C	ENST00000298552.3	-	23	3447	c.3226A>G	c.(3226-3228)Acc>Gcc	p.T1076A	TSC1_ENST00000440111.2_Missense_Mutation_p.T1076A|TSC1_ENST00000545250.1_Missense_Mutation_p.T1025A	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	1076					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CCCACAGTGGTGGGGATGCTG	0.557000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				22	88					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53722996	53722996	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:53722996C>G	ENST00000306052.6	-	15	2451	c.2350G>C	c.(2350-2352)Gtc>Ctc	p.V784L	LRP8_ENST00000354412.3_Intron|LRP8_ENST00000465675.1_Missense_Mutation_p.V337L|LRP8_ENST00000371454.2_Missense_Mutation_p.V784L|LRP8_ENST00000347547.2_Missense_Mutation_p.V614L|LRP8_ENST00000460214.1_5'UTR	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	784	Clustered O-linked oligosaccharides.				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						GAGCTTGGGACTGCAGCTGTC	0.592000													24	49					0	0	1	0	0
SLC25A48	153328	broad.mit.edu	37	5	135188294	135188294	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:135188294A>G	ENST00000274513.5	+	4	377	c.205A>G	c.(205-207)Att>Gtt	p.I69V	SLC25A48_ENST00000420621.1_Missense_Mutation_p.I69V|SLC25A48_ENST00000412661.2_Missense_Mutation_p.I69V|SLC25A48_ENST00000433282.2_Missense_Mutation_p.I15V|SLC25A48_ENST00000425402.1_Intron			Q6ZT89	S2548_HUMAN	solute carrier family 25, member 48	69					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						CCTCGCCAGCATTGCCGTCTA	0.627000													20	264					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110131623	110131623	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:110131623C>G	ENST00000518632.1	+	3	1487	c.1136C>G	c.(1135-1137)gCc>gGc	p.A379G	TRHR_ENST00000311762.2_Missense_Mutation_p.A379G			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	379						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TACCTGTCTGCCACAAAAGTG	0.418000													14	140					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112177340	112177340	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:112177340A>G	ENST00000457016.1	+	16	6429	c.6049A>G	c.(6049-6051)Acc>Gcc	p.T2017A	APC_ENST00000508376.2_Missense_Mutation_p.T2017A|APC_ENST00000257430.4_Missense_Mutation_p.T2017A|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	2017	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		tgttgaagataccccagtttg	0.418000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			33	90					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56497784	56497784	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:56497784A>T	ENST00000370754.5	-	27	3573	c.3574T>A	c.(3574-3576)Tct>Act	p.S1192T	DST_ENST00000370769.4_Missense_Mutation_p.S1014T|DST_ENST00000312431.6_Missense_Mutation_p.S1014T|DST_ENST00000421834.2_Missense_Mutation_p.S1014T|DST_ENST00000370788.2_Missense_Mutation_p.S1014T|DST_ENST00000446842.2_Missense_Mutation_p.S688T|DST_ENST00000361203.3_Missense_Mutation_p.S1014T|DST_ENST00000370765.6_Missense_Mutation_p.S688T|DST_ENST00000244364.6_Missense_Mutation_p.S688T|DST_ENST00000518935.1_Missense_Mutation_p.S688T			Q03001	DYST_HUMAN	dystonin	1014					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCAAAACGAGATTGTAGATTA	0.358000													12	54					0	0	1	0	0
WBSCR27	155368	broad.mit.edu	37	7	73254873	73254873	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:73254873C>T	ENST00000297873.4	-	4	308	c.259G>A	c.(259-261)Gct>Act	p.A87T		NM_152559.2	NP_689772.2	Q8N6F8	WBS27_HUMAN	Williams Beuren syndrome chromosome region 27	87										NS(1)|central_nervous_system(1)|lung(2)|prostate(1)	5		Lung NSC(55;0.159)				AAGCCTGGAGCCCGCAGCTGG	0.662000													10	24					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141551423	141551423	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:141551423T>C	ENST00000220592.5	-	15	1986	c.1874A>G	c.(1873-1875)tAc>tGc	p.Y625C	AGO2_ENST00000519980.1_Missense_Mutation_p.Y625C	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		GGTGGCGCAGTAGCGATTGGG	0.622000													7	40					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37650864	37650864	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:37650864G>A	ENST00000447079.4	+	5	2369	c.2336G>A	c.(2335-2337)cGt>cAt	p.R779H	CDK12_ENST00000430627.2_Missense_Mutation_p.R779H	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	779	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AAAATCCTTCGTCAGTTAatc	0.408000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			9	26					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70594434	70594434	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:70594434A>G	ENST00000260126.3	-	7	2473	c.1767T>C	c.(1765-1767)ggT>ggC	p.G589G	SLCO5A1_ENST00000524945.1_Silent_p.G589G|SLCO5A1_ENST00000530307.1_Silent_p.G534G	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	589	Kazal-like.					integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGCTAAGATTACCACTATTAA	0.408000													57	117					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419195	123419195	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:123419195G>A	ENST00000360772.3	-	19	3498	c.3120C>T	c.(3118-3120)aaC>aaT	p.N1040N	MYLK_ENST00000346322.5_Silent_p.N971N|MYLK_ENST00000360304.3_Silent_p.N1040N|MYLK_ENST00000475616.1_Silent_p.N1040N|MYLK_ENST00000359169.1_Silent_p.N1040N			Q15746	MYLK_HUMAN	myosin light chain kinase	1040	6 X 12 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAGGCTTGGCGTTGCCCATTG	0.557000													90	267					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56091548	56091548	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56091548A>G	ENST00000257880.7	-	10	1691	c.1472T>C	c.(1471-1473)tTg>tCg	p.L491S	ITGA7_ENST00000257879.6_Missense_Mutation_p.L447S|ITGA7_ENST00000347027.6_Missense_Mutation_p.L447S|ITGA7_ENST00000394229.2_Missense_Mutation_p.L447S|ITGA7_ENST00000452168.2_Missense_Mutation_p.L354S|ITGA7_ENST00000555728.1_Missense_Mutation_p.L491S|ITGA7_ENST00000394230.2_Missense_Mutation_p.L451S|ITGA7_ENST00000553804.1_Missense_Mutation_p.L451S			Q13683	ITA7_HUMAN	integrin, alpha 7	491					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						ATCCATATCCAAGCTGCCTGA	0.607000													6	190					0	0	1	0	0
SAE1	10055	broad.mit.edu	37	19	47712512	47712512	+	Nonsense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:47712512C>G	ENST00000413379.3	+	7	932	c.830C>G	c.(829-831)tCa>tGa	p.S277*	SAE1_ENST00000270225.7_3'UTR|SAE1_ENST00000392776.3_3'UTR|SAE1_ENST00000540850.1_3'UTR|SAE1_ENST00000598840.1_3'UTR	NM_001145713.1	NP_001139185.1	Q9UBE0	SAE1_HUMAN	SUMO1 activating enzyme subunit 1	0					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			endometrium(3)|large_intestine(5)|lung(4)|ovary(1)	13		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		CAAGTGAACTCAAGATTTGGC	0.547000													19	53					0	0	1	0	0
DDO	8528	broad.mit.edu	37	6	110734649	110734649	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:110734649A>G	ENST00000368924.3	-	2	116	c.101T>C	c.(100-102)aTt>aCt	p.I34T	DDO_ENST00000368925.1_Missense_Mutation_p.I6T|DDO_ENST00000368923.3_Missense_Mutation_p.I34T	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	6					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GACAACTGCAATCCGTGCTGT	0.507000													55	155					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480729	57480729	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:57480729G>A	ENST00000371236.2	-	12	1534	c.1271C>T	c.(1270-1272)cCg>cTg	p.P424L	DAB1_ENST00000439789.2_Missense_Mutation_p.P338L|DAB1_ENST00000414851.2_Missense_Mutation_p.P406L|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371231.1_Missense_Mutation_p.P457L|DAB1_ENST00000420954.2_Missense_Mutation_p.P422L|DAB1_ENST00000371234.4_Missense_Mutation_p.P424L			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	457					cell differentiation|nervous system development			p.P424L(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GGGCACGGGCGGAGGCTGGGC	0.582000													24	65					0	0	1	0	0
MOBP	4336	broad.mit.edu	37	3	39543701	39543701	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:39543701T>C	ENST00000311042.6	+	3	290	c.141T>C	c.(139-141)tgT>tgC	p.C47C	MOBP_ENST00000420739.1_Silent_p.C47C|MOBP_ENST00000396228.1_Silent_p.C47C|MOBP_ENST00000415443.1_Silent_p.C47C|MOBP_ENST00000383754.3_Silent_p.C47C|MOBP_ENST00000428261.1_Silent_p.C47C|MOBP_ENST00000354668.4_Silent_p.C47C|MOBP_ENST00000447324.1_Silent_p.C47C|MOBP_ENST00000441980.2_Silent_p.C47C	NM_001278322.1	NP_001265251.1	Q13875	MOBP_HUMAN	myelin-associated oligodendrocyte basic protein	47					nervous system development	nucleolus|perinuclear region of cytoplasm|soluble fraction		p.C47W(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.082)|Kidney(284;0.0998)		ACAGCATCTGTAAGAGCGGCT	0.557000													19	71					0	0	1	0	0
C3orf62	375341	broad.mit.edu	37	3	49311557	49311557	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49311557C>G	ENST00000343010.3	-	2	1499	c.463G>C	c.(463-465)Gat>Cat	p.D155H	MIR4271_ENST00000582451.1_RNA	NM_198562.2	NP_940964.1	Q6ZUJ4	CC062_HUMAN	chromosome 3 open reading frame 62	155										breast(1)|kidney(1)|large_intestine(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCTTCAAATCTCTCTCCATA	0.448000													25	58					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2143020	2143020	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2143020G>A	ENST00000262304.4	-	38	11299	c.11091C>T	c.(11089-11091)caC>caT	p.H3697H	RP11-304L19.1_ENST00000570072.1_RNA|PKD1_ENST00000423118.1_Silent_p.H3696H	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3697					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GACGGTAGGCGTGCCCATGGC	0.642000													49	148					0	0	1	0	0
TMEM209	84928	broad.mit.edu	37	7	129813778	129813778	+	Splice_Site	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:129813778A>T	ENST00000397622.2	-	12	1468	c.1344_splice	c.e12-1	p.I449_splice	RP11-775D22.3_ENST00000483283.1_RNA|TMEM209_ENST00000462753.1_Splice_Site_p.I448_splice|TMEM209_ENST00000336804.8_Splice_Site_p.I406_splice|TMEM209_ENST00000473456.1_Splice_Site_p.I407_splice	NM_032842.3	NP_116231.2	Q96SK2	TM209_HUMAN	transmembrane protein 209	449						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	12	Melanoma(18;0.0435)					ATGCATGATGATCTGAGGATG	0.353000													6	207					0	0	1	0	0
CEP76	79959	broad.mit.edu	37	18	12674619	12674619	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:12674619G>A	ENST00000262127.2	-	11	1982	c.1757C>T	c.(1756-1758)gCt>gTt	p.A586V	CEP76_ENST00000423709.2_Missense_Mutation_p.A511V|RP11-973H7.2_ENST00000585331.1_RNA	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	586					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ATCAGGTACAGCCCTTCTTAT	0.398000													33	76					0	0	1	0	0
ISL2	64843	broad.mit.edu	37	15	76633580	76633580	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:76633580T>C	ENST00000290759.4	+	5	1061	c.901T>C	c.(901-903)Tgg>Cgg	p.W301R	RP11-685G9.2_ENST00000559539.1_RNA	NM_145805.1	NP_665804.1	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	301						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6						CCAGCCGCCGTGGAAGGCGCT	0.687000													6	18					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409581	59409581	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:59409581C>T	ENST00000301645.3	-	3	627	c.490G>A	c.(490-492)Gct>Act	p.A164T		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	164					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ACCCAGGCAGCGGTCTTTGAG	0.488000									Neonatal Giant Cell Hepatitis				18	263					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39818098	39818098	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:39818098C>A	ENST00000553728.1	+	27	3983	c.3770C>A	c.(3769-3771)cCt>cAt	p.P1257H	CTAGE5_ENST00000557038.1_Missense_Mutation_p.P642H|CTAGE5_ENST00000396158.2_Missense_Mutation_p.P727H|CTAGE5_ENST00000348007.3_Missense_Mutation_p.P679H|CTAGE5_ENST00000341749.3_Missense_Mutation_p.P710H|CTAGE5_ENST00000553352.1_Missense_Mutation_p.P693H|CTAGE5_ENST00000396165.4_Missense_Mutation_p.P693H|CTAGE5_ENST00000341502.5_Missense_Mutation_p.P722H|CTAGE5_ENST00000280083.3_Missense_Mutation_p.P722H|CTAGE5_ENST00000553383.1_3'UTR|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.P693H|CTAGE5_ENST00000556148.1_Missense_Mutation_p.P647H																							TTCCCCCCACCTCCTCCAGGA	0.507000													15	269					2.32078e-09	2.39896e-09	1	1	0
C1orf131	128061	broad.mit.edu	37	1	231376829	231376829	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:231376829G>A	ENST00000318906.2	-	1	87	c.59C>T	c.(58-60)tCc>tTc	p.S20F	C1orf131_ENST00000366649.2_Missense_Mutation_p.S20F|C1orf131_ENST00000366651.3_Missense_Mutation_p.S20F|C1orf131_ENST00000471936.1_5'UTR			Q8NDD1	CA131_HUMAN	chromosome 1 open reading frame 131	20										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	8	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				GGGAGGCGTGGAGGACCCCGG	0.627000													17	167					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32032761	32032761	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32032761G>A	ENST00000375244.3	-	19	6879	c.6678C>T	c.(6676-6678)gtC>gtT	p.V2226V	TNXB_ENST00000375247.2_Silent_p.V2226V			P22105	TENX_HUMAN	tenascin XB	2298	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCTTAAACTGGACCAAGAAAT	0.607000													5	24					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140297593	140297593	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:140297593T>C	ENST00000296543.5	+	16	2345	c.2022T>C	c.(2020-2022)acT>acC	p.T674T	NAA15_ENST00000398947.1_Silent_p.T674T	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	674					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AGATAGAGACTCATCTTTTTG	0.348000													5	77					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160093055	160093055	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:160093055C>T	ENST00000361216.3	+	4	319	c.230C>T	c.(229-231)gCc>gTc	p.A77V	ATP1A2_ENST00000392233.3_Missense_Mutation_p.A77V|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	77					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGGCCCAACGCCCTCACACCA	0.632000													60	184					0	0	1	0	0
ACCS	84680	broad.mit.edu	37	11	44089200	44089200	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:44089200A>T	ENST00000263776.8	+	2	457	c.23A>T	c.(22-24)gAc>gTc	p.D8V	ACCS_ENST00000533208.1_3'UTR|ACCS_ENST00000432284.2_Missense_Mutation_p.D8V	NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	8							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						CCTCAAAAGGACTTCAGGGCT	0.537000													24	90					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595075	140595075	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140595075C>T	ENST00000341948.4	+	1	1567	c.1380C>T	c.(1378-1380)gtC>gtT	p.V460V		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		460	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGTTCGTCCGCGAGAACA	0.607000													6	355					0	0	1	0	0
DCP1A	55802	broad.mit.edu	37	3	53326391	53326391	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:53326391C>T	ENST00000607628.1	-	7	1200	c.1091G>A	c.(1090-1092)aGc>aAc	p.S364N	DCP1A_ENST00000294241.6_Missense_Mutation_p.S364N|DCP1A_ENST00000606822.1_Missense_Mutation_p.S326N|DCP1A_ENST00000480258.1_5'UTR	NM_018403.5	NP_060873.4	Q9NPI6	DCP1A_HUMAN	decapping mRNA 1A	364					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		ACTGGCATGGCTTAGCTCAGG	0.567000													32	89					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136402990	136402990	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:136402990A>G	ENST00000264160.4	+	16	1886	c.1516A>G	c.(1516-1518)Aat>Gat	p.N506D	R3HDM1_ENST00000443537.2_3'UTR|R3HDM1_ENST00000409606.1_Missense_Mutation_p.N506D|R3HDM1_ENST00000410054.1_Missense_Mutation_p.N450D|R3HDM1_ENST00000409478.1_Missense_Mutation_p.N377D|R3HDM1_ENST00000329971.3_Missense_Mutation_p.N377D	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	506							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		AGTTGTGTATAATCCTCCTAT	0.448000													9	123					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40035067	40035067	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:40035067C>T	ENST00000352035.2	-	21	2506	c.2376G>A	c.(2374-2376)gaG>gaA	p.E792E	ACLY_ENST00000537919.1_Silent_p.E521E|ACLY_ENST00000590151.1_Silent_p.E792E|ACLY_ENST00000393896.2_Silent_p.E782E|ACLY_ENST00000353196.1_Silent_p.E782E	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	792					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				TCTCTCCAAGCTCATCAAAGC	0.567000													18	132					0	0	1	0	0
EIF1AX	1964	broad.mit.edu	37	X	20153883	20153883	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:20153883A>G	ENST00000379607.5	-	3	380	c.177T>C	c.(175-177)tgT>tgC	p.C59C	EIF1AX_ENST00000379593.1_Silent_p.C31C	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	59	S1-like.					cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						CTCTGATGTGACATAACCTCT	0.383000													4	87					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877213	27877213	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:27877213G>A	ENST00000374011.2	-	6	2382	c.1414C>T	c.(1414-1416)Cgg>Tgg	p.R472W	AHDC1_ENST00000247087.5_Missense_Mutation_p.R472W|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	472							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		ACCATGCGCCGCACGCCCCGG	0.627000													9	28					0	0	1	0	0
UNC50	25972	broad.mit.edu	37	2	99226389	99226389	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99226389T>C	ENST00000409975.1	+	1	1348	c.218T>C	c.(217-219)cTg>cCg	p.L73P	UNC50_ENST00000409347.1_Missense_Mutation_p.L73P|UNC50_ENST00000357765.2_Missense_Mutation_p.L56P			Q53HI1	UNC50_HUMAN	unc-50 homolog (C. elegans)	56					protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding			breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)	10						ATGCTCTACCTGTTCACATCC	0.473000													4	124					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	459895	459895	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:459895G>A	ENST00000399788.2	-	10	1562	c.1200C>T	c.(1198-1200)agC>agT	p.S400S	KDM5A_ENST00000382815.4_Silent_p.S400S	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	400					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						CTTCTTCAATGCTGCTTACCA	0.398000			T	NUP98	AML								13	78					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89616155	89616155	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:89616155T>C	ENST00000294671.2	-	6	867	c.729A>G	c.(727-729)aaA>aaG	p.K243K		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	243						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GTAAGAGTTTTTTGTCATTTA	0.388000													16	78					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	31983619	31983619	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:31983619C>A	ENST00000438447.1	+	3	1223	c.835C>A	c.(835-837)Ccc>Acc	p.P279T	PDZD2_ENST00000282493.3_Missense_Mutation_p.P279T			O15018	PDZD2_HUMAN	PDZ domain containing 2	279					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GGTGGCTGGACCCCATCTAGA	0.527000													4	137					2.56e-06	2.6216e-06	1	1	0
DTX1	1840	broad.mit.edu	37	12	113496126	113496126	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:113496126C>T	ENST00000257600.3	+	1	632	c.129C>T	c.(127-129)acC>acT	p.T43T		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	43	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						ACACGGCCACCGTGTGCCACC	0.652000													23	133					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136573485	136573485	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:136573485G>A	ENST00000371872.4	-	11	1651	c.1394C>T	c.(1393-1395)gCc>gTc	p.A465V	SARDH_ENST00000422262.2_Missense_Mutation_p.A297V|SARDH_ENST00000439388.1_Missense_Mutation_p.A465V	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	465					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GTAGTTCTTGGCGTAGGACTC	0.652000													20	190					0	0	1	0	0
PEX3	8504	broad.mit.edu	37	6	143795986	143795986	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:143795986T>C	ENST00000367591.4	+	9	874	c.811T>C	c.(811-813)Ttg>Ctg	p.L271L		NM_003630.2	NP_003621.1	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	271					protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			endometrium(1)|large_intestine(9)|lung(4)|ovary(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		TAGAGACATGTTGGAAAGGTA	0.338000													5	104					0	0	1	0	0
CCT5	22948	broad.mit.edu	37	5	10258521	10258521	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:10258521A>G	ENST00000280326.4	+	6	1167	c.747A>G	c.(745-747)gcA>gcG	p.A249A	CCT5_ENST00000503026.1_Silent_p.A228A|CCT5_ENST00000506600.1_Silent_p.A156A|CCT5_ENST00000515676.1_Silent_p.A211A|CCT5_ENST00000515390.1_Silent_p.A194A	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	249					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						CGAAGATTGCAATTCTCACAT	0.403000													49	110					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671444	31671444	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:31671444T>C	ENST00000375483.3	+	3	441	c.441T>C	c.(439-441)ctT>ctC	p.L147L		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	147	Gly-rich.					cytoplasm|extracellular region	lipid binding										TGGGCAGGCTTCACCGGCGAG	0.647000													29	85					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18710432	18710432	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:18710432G>A	ENST00000392386.3	-	2	533	c.340C>T	c.(340-342)Ctc>Ttc	p.L114F		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	114	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						TGGCACACGAGGTTGTCCCCC	0.672000													14	44					0	0	1	0	0
CBWD6	644019	broad.mit.edu	37	9	69247573	69247573	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:69247573C>T	ENST00000377457.5	-	5	544	c.439G>A	c.(439-441)Gct>Act	p.A147T	CBWD6_ENST00000382399.4_Intron|CBWD6_ENST00000377449.1_Missense_Mutation_p.A111T	NM_001085457.1	NP_001078926.1	Q4V339	CBWD6_HUMAN	COBW domain containing 6	147							ATP binding			lung(4)	4						AACATAGAAGCCACTGCACGT	0.269000													4	27					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102808375	102808375	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:102808375A>G	ENST00000262236.5	+	8	2656	c.2301A>G	c.(2299-2301)ttA>ttG	p.L767L	ZNF839_ENST00000442396.2_Silent_p.L881L|ZNF839_ENST00000420933.2_3'UTR|ZNF839_ENST00000559185.1_Silent_p.L765L|ZNF839_ENST00000558850.1_Silent_p.L765L	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	765						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GCCATGAGTTACTGTCTCAGG	0.512000													11	64					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95825905	95825905	+	Silent	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:95825905T>A	ENST00000524717.1	-	2	2574	c.1290A>T	c.(1288-1290)gtA>gtT	p.V430V		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	430					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				GGGCATGGGATACTTCCTGCC	0.607000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								6	78					0	0	1	0	0
TCEB1	6921	broad.mit.edu	37	8	74868286	74868286	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:74868286C>T	ENST00000602840.1	-	3	202	c.8G>A	c.(7-9)gGa>gAa	p.G3E	TCEB1_ENST00000523815.1_Missense_Mutation_p.G3E|TCEB1_ENST00000519487.1_Missense_Mutation_p.G3E|TCEB1_ENST00000520210.1_5'UTR|TCEB1_ENST00000520242.1_Missense_Mutation_p.G3E|TCEB1_ENST00000284811.8_Missense_Mutation_p.G3E|TCEB1_ENST00000518127.1_Missense_Mutation_p.G3E|TCEB1_ENST00000522337.1_Missense_Mutation_p.G3E			Q15369	ELOC_HUMAN	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	3					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding			endometrium(2)|kidney(3)|lung(1)|prostate(1)	7	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)			TTTCTCCTCTCCATCTAAAGT	0.408000													15	99					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674247	167674247	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:167674247A>G	ENST00000519204.1	+	26	6058	c.5940A>G	c.(5938-5940)gcA>gcG	p.A1980A	TENM2_ENST00000520394.1_Silent_p.A1862A|TENM2_ENST00000403607.2_Silent_p.A1925A|TENM2_ENST00000518659.1_Silent_p.A2101A|TENM2_ENST00000545108.1_Silent_p.A2100A					teneurin transmembrane protein 2																		TCCGCATCGCAAGCATCAAGC	0.517000													20	223					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39422641	39422641	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:39422641A>G	ENST00000280481.7	+	8	6429	c.6213A>G	c.(6211-6213)gcA>gcG	p.A2071A	FREM2_ENST00000482551.1_3'UTR	NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2071	Calx-beta 3.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TAGATTTTGCACCTGGAGTCA	0.413000													19	182					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96136711	96136711	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:96136711C>T	ENST00000324765.8	+	5	928	c.581C>T	c.(580-582)cCg>cTg	p.P194L	DIAPH2_ENST00000373049.4_Missense_Mutation_p.P194L|DIAPH2_ENST00000373061.3_Missense_Mutation_p.P194L|DIAPH2_ENST00000355827.4_Missense_Mutation_p.P194L|DIAPH2_ENST00000373054.4_Missense_Mutation_p.P190L			O60879	DIAP2_HUMAN	diaphanous-related formin 2	194	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding	p.P194L(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						ACCAGCAATCCGGTCAGGTAA	0.343000													20	24					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67305080	67305080	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67305080G>A	ENST00000299798.11	+	16	2723	c.2658G>A	c.(2656-2658)tgG>tgA	p.W886*		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	886					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CCTCCCACTGGTGCATCCAGT	0.642000													18	36					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228394	142228394	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:142228394T>C	ENST00000519067.1	-	4	1495	c.1192A>G	c.(1192-1194)Atc>Gtc	p.I398V	SLC45A4_ENST00000024061.3_Missense_Mutation_p.I398V|SLC45A4_ENST00000433583.2_Missense_Mutation_p.I391V|SLC45A4_ENST00000517878.1_Missense_Mutation_p.I449V			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	449					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GACGGCTTGATCAGCACCACG	0.687000													20	80					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22211843	22211843	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:22211843A>G	ENST00000356766.6	+	22	2865	c.2717A>G	c.(2716-2718)tAt>tGt	p.Y906C	PIWIL2_ENST00000521356.1_Intron|PIWIL2_ENST00000454009.2_Missense_Mutation_p.Y906C	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	906	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CCTACGCATTATGTCTGTGTT	0.458000													5	119					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161737	43161737	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:43161737G>A	ENST00000352483.2	-	9	1824	c.1760C>T	c.(1759-1761)aCg>aTg	p.T587M	RIPK4_ENST00000332512.3_Missense_Mutation_p.T539M|RIPK4_ENST00000544709.1_Missense_Mutation_p.T476M|RIPK4_ENST00000542057.1_Missense_Mutation_p.T476M			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	539						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GTGCATGGGCGTCCGGCCCTC	0.647000													10	55					0	0	1	0	0
IQCG	84223	broad.mit.edu	37	3	197639589	197639589	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:197639589C>T	ENST00000265239.6	-	9	1344	c.920G>A	c.(919-921)cGg>cAg	p.R307Q	IQCG_ENST00000455191.1_Missense_Mutation_p.R307Q	NM_032263.3	NP_115639.1	Q9H095	IQCG_HUMAN	IQ motif containing G	307										autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TGTATGAGTCCGGGCCTCTTC	0.448000													68	218					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62634740	62634740	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:62634740T>C	ENST00000337910.5	-	9	2124	c.1787A>G	c.(1786-1788)gAa>gGa	p.E596G	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.E596G|RHOBTB1_ENST00000490827.1_5'UTR	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	596					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGAGAGCACTTCTCCGTCAAT	0.463000													26	96					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759038	6759038	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:6759038A>G	ENST00000378827.4	+	3	1712	c.493A>G	c.(493-495)Agc>Ggc	p.S165G		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	165					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	AGGAAACAATAGCAGTTTCCA	0.408000													20	52					0	0	1	0	0
LSAMP	4045	broad.mit.edu	37	3	116163801	116163801	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:116163801T>C	ENST00000539563.1	-	2	68	c.67_splice	c.e2-1	p.G23_splice	LSAMP_ENST00000490035.1_Silent_p.G26G			Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	26					cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GAACAGGCAGTCCTGTGGGAA	0.587000													20	48					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52882330	52882330	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52882330G>A	ENST00000330722.6	-	7	1274	c.1206C>T	c.(1204-1206)tgC>tgT	p.C402C		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	402	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCAGGTTGGCGCACTGGAAGA	0.562000													40	75					0	0	1	0	0
ACADL	33	broad.mit.edu	37	2	211085431	211085431	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:211085431T>A	ENST00000233710.3	-	2	400	c.173A>T	c.(172-174)gAc>gTc	p.D58V	AC006994.2_ENST00000412065.1_RNA	NM_001608.3	NP_001599.1	P28330	ACADL_HUMAN	acyl-CoA dehydrogenase, long chain	58					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	14		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		CCGGAAAATGTCATGCTCTGG	0.378000													16	37					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	96971092	96971092	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:96971092A>G	ENST00000369278.4	+	2	214	c.148A>G	c.(148-150)Aca>Gca	p.T50A		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	50	Required for E3 UFM1-protein ligase activity.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										AGTAGTTCATACACTCGATGG	0.363000													27	93					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28601232	28601232	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:28601232T>C	ENST00000380982.4	-	17	2281	c.2200A>G	c.(2200-2202)Aat>Gat	p.N734D	FLT3_ENST00000537084.1_Missense_Mutation_p.N734D|FLT3_ENST00000241453.7_Missense_Mutation_p.N734D			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	734	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TACCTGGAATTTGGATGTGAT	0.393000			"""Mis, O"""		"""AML, ALL"""								53	147					0	0	1	0	0
IQCK	124152	broad.mit.edu	37	16	19775178	19775178	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:19775178A>G	ENST00000320394.6	+	6	1182	c.483A>G	c.(481-483)agA>agG	p.R161R	CTD-2380F24.1_ENST00000568843.1_RNA|IQCK_ENST00000564186.1_Silent_p.R161R|IQCK_ENST00000433597.2_Silent_p.R73R|IQCK_ENST00000562762.1_3'UTR|CTD-2380F24.1_ENST00000564490.1_RNA|CTD-2380F24.1_ENST00000565817.1_RNA|IQCK_ENST00000541926.1_Silent_p.R161R	NM_153208.1	NP_694940.1	Q8N0W5	IQCK_HUMAN	IQ motif containing K	161										kidney(1)|large_intestine(2)|lung(2)|skin(1)	6						AGAGGAAAAGAACCAAATTCA	0.343000													17	53					0	0	1	0	0
SCO1	6341	broad.mit.edu	37	17	10600695	10600695	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10600695A>G	ENST00000255390.5	-	1	190	c.130T>C	c.(130-132)Ttc>Ctc	p.F44L	SCO1_ENST00000577427.1_Missense_Mutation_p.F44L	NM_004589.2	NP_004580.1	O75880	SCO1_HUMAN	SCO1 cytochrome c oxidase assembly protein	44					cellular copper ion homeostasis|copper ion transport|generation of precursor metabolites and energy|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	10						CGCGCGCAGAACTGCCTCAGC	0.692000													6	12					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416334	86416334	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:86416334G>A	ENST00000361669.2	+	3	2325	c.1226G>A	c.(1225-1227)cGc>cAc	p.R409H	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.R407H|GRM3_ENST00000439827.1_Missense_Mutation_p.R409H|GRM3_ENST00000536043.1_Missense_Mutation_p.R281H	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	409					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AAAATGCAGCGCACCCTCTGT	0.498000													63	145					0	0	1	0	0
TTLL1	25809	broad.mit.edu	37	22	43465725	43465725	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:43465725T>C	ENST00000331018.7	-	4	479	c.239A>G	c.(238-240)aAc>aGc	p.N80S	TTLL1_ENST00000266254.7_Missense_Mutation_p.N80S			O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	80	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		TCTTTTGATGTTCTTCACCAT	0.453000													52	170					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	667687	667687	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:667687T>A	ENST00000266383.5	+	18	2634	c.2621T>A	c.(2620-2622)aTc>aAc	p.I874N		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	874						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CCGCACAGCATCATCTTCCTC	0.592000													50	230					0	0	1	0	0
SNORD89	692205	broad.mit.edu	37	2	101889484	101889484	+	RNA	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:101889484C>T	ENST00000390981.1	-	0	27					NR_003070.1																						CACTGCAATTCGGCCTTTTCT	0.483000													27	71					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42236721	42236721	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:42236721T>C	ENST00000541110.1	-	5	1176	c.608A>G	c.(607-609)cAg>cGg	p.Q203R	TRERF1_ENST00000372922.4_Missense_Mutation_p.Q203R|TRERF1_ENST00000372917.4_Missense_Mutation_p.Q203R|TRERF1_ENST00000340840.2_Missense_Mutation_p.Q203R|TRERF1_ENST00000354325.2_Missense_Mutation_p.Q203R			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	203	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGGGGCACCTGCTGGTAGCG	0.617000													35	88					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8752085	8752085	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:8752085T>A	ENST00000534127.1	-	6	1137	c.752A>T	c.(751-753)gAc>gTc	p.D251V	ST5_ENST00000526757.1_Intron|ST5_ENST00000530438.1_Intron|ST5_ENST00000357665.1_Missense_Mutation_p.D251V|ST5_ENST00000313726.6_Missense_Mutation_p.D251V	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	251					positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		GTAGAAAGAGTCCCGGACAGG	0.627000													37	107					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134942243	134942243	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:134942243T>A	ENST00000607359.1	+	16	3068	c.3068T>A	c.(3067-3069)aTc>aAc	p.I1023N	GPR123_ENST00000392606.2_Missense_Mutation_p.I207N|GPR123_ENST00000392607.3_Missense_Mutation_p.I304N			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	304						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TTCGTGCTCATCCACCACTGC	0.687000													4	55					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40265842	40265842	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:40265842A>G	ENST00000263791.5	+	11	1753	c.1710A>G	c.(1708-1710)ctA>ctG	p.L570L	EIF2AK4_ENST00000559624.1_Silent_p.L570L|EIF2AK4_ENST00000382727.2_Silent_p.L570L	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	570					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GCAACCGGCTACCCAGTGCTG	0.418000													4	159					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53058337	53058337	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53058337T>C	ENST00000359798.4	+	5	2348	c.2168T>C	c.(2167-2169)gTa>gCa	p.V723A		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	723					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TCATCCCTTGTATGCCATCGT	0.433000													77	261					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917426	2917426	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2917426A>G	ENST00000306908.5	+	4	955	c.807A>G	c.(805-807)agA>agG	p.R269R	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Silent_p.R237R	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	269					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		CATTTCAAAGACACATGACAA	0.453000													7	107					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542754	187542754	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:187542754G>A	ENST00000441802.2	-	10	5195	c.4986C>T	c.(4984-4986)aaC>aaT	p.N1662N		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1662	Cadherin 14.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCGGAGAGGCGTTGTCAGCAA	0.408000										HNSCC(5;0.00058)			12	65					0	0	1	0	0
HSD3B7	80270	broad.mit.edu	37	16	30997480	30997480	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30997480T>C	ENST00000262520.6	+	3	567	c.277T>C	c.(277-279)Ttt>Ctt	p.F93L	HSD3B7_ENST00000353250.5_Missense_Mutation_p.F93L|AC135048.1_ENST00000602217.1_Silent_p.K18K|HSD3B7_ENST00000297679.5_Missense_Mutation_p.F93L	NM_001142777.1	NP_001136249.1	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	93					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GGTAGACGTGTTTGGCAGGGC	0.622000													18	33					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25260936	25260936	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:25260936T>C	ENST00000354454.3	+	21	2271	c.1442T>C	c.(1441-1443)cTa>cCa	p.L481P	LRMP_ENST00000548766.1_Missense_Mutation_p.L481P|LRMP_ENST00000547044.1_Missense_Mutation_p.L481P	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	537					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					TGGACGTCTCTAGAACATATC	0.463000													7	137					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45745855	45745855	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45745855A>G	ENST00000403390.1	+	21	2142	c.2142A>G	c.(2140-2142)ccA>ccG	p.P714P	PFKL_ENST00000349048.4_Silent_p.P667P			P17858	K6PL_HUMAN	phosphofructokinase, liver	667					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GTGGCGCTCCAACCCCCTTTG	0.652000													10	23					0	0	1	0	0
ATP5G2	517	broad.mit.edu	37	12	54063664	54063664	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:54063664C>T	ENST00000338662.5	-	3	1361	c.156G>A	c.(154-156)ctG>ctA	p.L52L	ATP5G2_ENST00000602871.1_Silent_p.L36L|ATP5G2_ENST00000394349.3_Silent_p.L93L|ATP5G2_ENST00000549164.1_Silent_p.L36L	NM_001002031.2	NP_001002031.1	Q06055	AT5G2_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)	36					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding			kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6						CCTCATCTGTCAGTATCTCCG	0.557000													39	54					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123888058	123888058	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:123888058A>C	ENST00000373855.1	+	14	2129	c.1869A>C	c.(1867-1869)gaA>gaC	p.E623D	CNTRL_ENST00000238341.5_Missense_Mutation_p.E623D|CNTRL_ENST00000373847.1_Missense_Mutation_p.E71D|CNTRL_ENST00000373850.1_Missense_Mutation_p.E71D			Q7Z7A1	CNTRL_HUMAN	centriolin	623					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GGTTGCAAGAATACCTGGGGA	0.453000													4	218					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99077025	99077025	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:99077025C>A	ENST00000357310.1	+	15	2728	c.2151C>A	c.(2149-2151)gcC>gcA	p.A717A	APAF1_ENST00000551964.1_Silent_p.A717A|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000550527.1_Silent_p.A706A|APAF1_ENST00000549007.1_Silent_p.A717A|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000547045.1_Silent_p.A717A|APAF1_ENST00000339433.3_Silent_p.A717A|APAF1_ENST00000359972.2_Silent_p.A706A	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	717					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TTCTCTTAGCCACTGGGTCAA	0.398000													34	159					2.75727e-19	2.90337e-19	1	1	0
MPRIP	23164	broad.mit.edu	37	17	17045965	17045965	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:17045965T>C	ENST00000395811.5	+	8	1010	c.921T>C	c.(919-921)ttT>ttC	p.F307F	MPRIP_ENST00000444976.1_Silent_p.F307F|MPRIP_ENST00000341712.4_Silent_p.F307F|MPRIP_ENST00000395804.3_Silent_p.F307F	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	307	Interaction with F-actin (By similarity).					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						TTGAAAAGTTTGAGGCCTTGG	0.607000													33	85					0	0	1	0	0
IL22RA2	116379	broad.mit.edu	37	6	137466909	137466909	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:137466909T>C	ENST00000296980.2	-	7	944	c.642_splice	c.e7-1	p.E215_splice	IL22RA2_ENST00000349184.4_Splice_Site_p.E183_splice|IL22RA2_ENST00000339602.3_Splice_Site_p.R126_splice	NM_052962.2	NP_443194.1	Q969J5	I22R2_HUMAN	interleukin 22 receptor, alpha 2	215	Fibronectin type-III 3.				regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity			endometrium(1)|large_intestine(1)|lung(3)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		AACCTTTTGCTCCTACACACG	0.413000													13	34					0	0	1	0	0
KRIT1	889	broad.mit.edu	37	7	91870364	91870364	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:91870364A>G	ENST00000394507.1	-	6	988	c.205T>C	c.(205-207)Ttg>Ctg	p.L69L	KRIT1_ENST00000412043.2_Silent_p.L69L|KRIT1_ENST00000394503.2_Silent_p.L69L|KRIT1_ENST00000340022.2_Silent_p.L69L|KRIT1_ENST00000394505.2_Silent_p.L69L	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	69					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACGTAATCCAATATGCCTTGT	0.338000													6	88					0	0	1	0	0
TEX29	121793	broad.mit.edu	37	13	111995122	111995122	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:111995122A>G	ENST00000283547.1	+	5	388	c.259A>G	c.(259-261)Aaa>Gaa	p.K87E		NM_152324.1	NP_689537.1	Q8N6K0	CM016_HUMAN	testis expressed 29	87						integral to membrane											GGAGAGCAGGAAAGAAAAGGC	0.547000													4	36					0	0	1	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86067278	86067278	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:86067278G>A	ENST00000377332.3	-	7	1354	c.1246C>T	c.(1246-1248)Cgt>Tgt	p.R416C	ST3GAL5_ENST00000393805.1_Missense_Mutation_p.R388C|ST3GAL5_ENST00000393808.3_Missense_Mutation_p.R393C	NM_003896.3	NP_003887.3	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	416					ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15						CAAAATTCACGATCAATGCCT	0.413000													22	72					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9068952	9068952	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:9068952G>A	ENST00000457346.2	-	16	2027	c.1953C>T	c.(1951-1953)cgC>cgT	p.R651R	SCUBE2_ENST00000520467.1_Silent_p.R651R|SCUBE2_ENST00000450649.2_Silent_p.R496R|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000309263.3_Silent_p.R622R			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	622						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ACTCTGCCTGGCGTTCAGATG	0.557000													5	85					0	0	1	0	0
GSG1	83445	broad.mit.edu	37	12	13243713	13243713	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:13243713G>T	ENST00000337630.6	-	2	116	c.49C>A	c.(49-51)Cta>Ata	p.L17I	GSG1_ENST00000396302.3_Missense_Mutation_p.L17I|GSG1_ENST00000537302.1_Missense_Mutation_p.L17I|GSG1_ENST00000324458.8_Missense_Mutation_p.L30I|GSG1_ENST00000457134.2_Missense_Mutation_p.L17I|GSG1_ENST00000432710.2_Missense_Mutation_p.L30I|GSG1_ENST00000396310.2_Missense_Mutation_p.L14I|GSG1_ENST00000351606.6_Missense_Mutation_p.L30I	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	17						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		ATGGCAGATAGGAGTGTCCGC	0.562000													22	105					2.70639e-06	2.77089e-06	1	1	0
XAB2	56949	broad.mit.edu	37	19	7692197	7692197	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7692197A>G	ENST00000358368.4	-	4	491	c.454T>C	c.(454-456)Tat>Cat	p.Y152H	XAB2_ENST00000534844.1_Missense_Mutation_p.Y149H	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	152					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						AAGCGCAGATACAGGGGCCAA	0.647000								Direct reversal of damage;Nucleotide excision repair (NER)					12	41					0	0	1	0	0
GREM2	64388	broad.mit.edu	37	1	240656306	240656306	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:240656306C>T	ENST00000318160.4	-	2	736	c.470G>A	c.(469-471)tGc>tAc	p.C157Y		NM_022469.3	NP_071914.3	Q9H772	GREM2_HUMAN	gremlin 2, DAN family BMP antagonist	157	CTCK.				BMP signaling pathway	extracellular space	cytokine activity			endometrium(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	10		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CACGGACATGCACCGGCACTG	0.711000													5	107					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76455109	76455109	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:76455109G>T	ENST00000389840.5	-	61	9917	c.9793C>A	c.(9793-9795)Ctg>Atg	p.L3265M	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.L3274M					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATCCGGGACAGCTTCTCTTGT	0.587000													4	140					0.150653	0.150988	1	1	0
DVL1	1855	broad.mit.edu	37	1	1277865	1277865	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1277865C>T	ENST00000378888.5	-	3	525		c.e3-1		DVL1_ENST00000378891.5_Splice_Site			O14640	DVL1_HUMAN	dishevelled segment polarity protein 1						canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCAGGACCAGCTGTGGAGGGA	0.701000													11	17					0	0	1	0	0
CRK	1398	broad.mit.edu	37	17	1340185	1340185	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1340185C>T	ENST00000300574.2	-	2	646	c.506G>A	c.(505-507)tGg>tAg	p.W169*	CRK_ENST00000574295.1_Intron|CRK_ENST00000398970.5_Nonsense_Mutation_p.W169*|CRK_ENST00000572145.1_5'UTR	NM_016823.3	NP_058431.2	P46108	CRK_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog	169	SH3 1.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)	9				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		CGCATTCCACCACTGCTCTTC	0.502000													54	136					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48596173	48596173	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:48596173C>A	ENST00000262384.3	-	2	617	c.381G>T	c.(379-381)gtG>gtT	p.V127V	RP11-44I10.3_ENST00000563994.1_RNA	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	127					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TAGCCATGACCACAGCCTCAG	0.438000													16	53					1.5739e-10	1.63252e-10	1	1	0
CELSR3	1951	broad.mit.edu	37	3	48698495	48698495	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:48698495G>A	ENST00000544264.1	-	1	1853	c.1573C>T	c.(1573-1575)Cgc>Tgc	p.R525C	CELSR3_ENST00000164024.4_Missense_Mutation_p.R525C			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	525	Cadherin 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGGCCGAGCGCGGCCCGGGT	0.637000													16	45					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	129064949	129064949	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:129064949A>G	ENST00000325006.3	+	15	1729	c.1675A>G	c.(1675-1677)Aag>Gag	p.K559E	AHCYL2_ENST00000446544.2_Missense_Mutation_p.K558E|AHCYL2_ENST00000490911.1_Missense_Mutation_p.K456E|AHCYL2_ENST00000446212.1_Missense_Mutation_p.K457E|AHCYL2_ENST00000474594.1_Missense_Mutation_p.K456E|AHCYL2_ENST00000531335.2_Missense_Mutation_p.K478E	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	559					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GGGTCGCTATAAGCAGGATGT	0.448000													29	81					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149839965	149839965	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:149839965G>A	ENST00000370396.2	+	15	1763	c.1709G>A	c.(1708-1710)cGg>cAg	p.R570Q	MTM1_ENST00000413012.2_Missense_Mutation_p.R533Q|MTM1_ENST00000542741.1_3'UTR|MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000543350.1_Missense_Mutation_p.R455Q	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	570					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					TACATAAAGCGGCTTGAGGAA	0.512000													37	19					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107449632	107449632	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:107449632T>C	ENST00000394872.2	-	11	839	c.608A>G	c.(607-609)cAa>cGa	p.Q203R	COL4A6_ENST00000545689.1_Intron|COL4A6_ENST00000372216.4_Intron|COL4A6_ENST00000334504.7_Intron|COL4A6_ENST00000538570.1_Intron			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	206	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						GAATGGAGGTTGCCCTTGCTC	0.433000									Alport syndrome with Diffuse Leiomyomatosis				14	12					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14105421	14105421	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:14105421T>C	ENST00000235372.7	+	8	1987	c.1131T>C	c.(1129-1131)cgT>cgC	p.R377R	PRDM2_ENST00000311066.5_Silent_p.R377R|PRDM2_ENST00000343137.4_Silent_p.R176R|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Silent_p.R176R	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	377						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GGCTTGAGCGTCACATGCATA	0.453000													5	102					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17257070	17257070	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17257070C>T	ENST00000375541.5	+	7	899	c.830C>T	c.(829-831)gCg>gTg	p.A277V	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	277					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CGGGAGGCGGCGTGGAGGCGC	0.662000													9	40					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957582	49957582	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:49957582T>C	ENST00000376056.2	-	5	1905	c.1755A>G	c.(1753-1755)aaA>aaG	p.K585K	AKAP4_ENST00000358526.2_Silent_p.K594K|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Silent_p.K211K|AKAP4_ENST00000376064.3_Silent_p.K585K			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	594					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					CTGAAAGTGCTTTGGCACTTT	0.468000													36	30					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96394781	96394781	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:96394781A>G	ENST00000228740.2	-	19	1963	c.1822T>C	c.(1822-1824)Tta>Cta	p.L608L	LTA4H_ENST00000413268.2_3'UTR|LTA4H_ENST00000552789.1_Silent_p.L584L|RP11-256L6.3_ENST00000551849.1_RNA	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	608					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						TCCACTTTTAAGTCTTTCCCC	0.388000													17	110					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6173014	6173014	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:6173014G>C	ENST00000262450.3	-	34	5056	c.4957C>G	c.(4957-4959)Ctg>Gtg	p.L1653V	CHD5_ENST00000378021.1_Missense_Mutation_p.L510V	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1653					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ATCAAGCTCAGCTCCAGCTTG	0.582000													20	75					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145106259	145106259	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145106259A>G	ENST00000426825.1	-	28	3916	c.3835T>C	c.(3835-3837)Tat>Cat	p.Y1279H	OPLAH_ENST00000534424.1_5'UTR|CTD-3065J16.6_ENST00000528912.1_RNA	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1279							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CGATACTCATAGACGCTGCCG	0.692000													21	78					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12977561	12977561	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:12977561G>A	ENST00000273221.4	-	3	1213	c.997C>T	c.(997-999)Cgg>Tgg	p.R333W		NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	333					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCCCGTAGCCGCAGGTCCGAC	0.682000													28	73					0	0	1	0	0
IL9R	3581	broad.mit.edu	37	X	155233458	155233458	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:155233458A>G	ENST00000424344.3	+	5	675	c.308A>G	c.(307-309)cAc>cGc	p.H103R	IL9R_ENST00000540897.1_Missense_Mutation_p.T159A|IL9R_ENST00000369423.2_Missense_Mutation_p.T169A|IL9R_ENST00000244174.5_Missense_Mutation_p.H124R			Q01113	IL9R_HUMAN	interleukin 9 receptor	124					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACTTTCCACCACTGCATGTCT	0.622000													15	56					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1268602	1268602	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1268602A>G	ENST00000447027.1	+	31	10559	c.10501A>G	c.(10501-10503)Acc>Gcc	p.T3501A	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.T3498A			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3498	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCAGCAGCAACCACCAGTAC	0.662000													4	266					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201534320	201534320	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:201534320T>A	ENST00000374700.2	+	34	4062	c.3821T>A	c.(3820-3822)tTc>tAc	p.F1274Y	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	1274					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TCGGGGGTGTTCCTGGGGTGT	0.498000													88	266					0	0	1	0	0
CHUK	1147	broad.mit.edu	37	10	101969541	101969541	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:101969541T>C	ENST00000370397.7	-	10	1025	c.939A>G	c.(937-939)gtA>gtG	p.V313V		NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	313					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		TTAGGATGTGTACTATCTGTA	0.328000													7	24					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37267572	37267572	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:37267572A>G	ENST00000233099.5	-	20	3041	c.2946T>C	c.(2944-2946)ctT>ctC	p.L982L	HEATR5B_ENST00000354531.2_Silent_p.L982L	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	982							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				ACAGCAAGGTAAGAACTAGAG	0.423000													25	87					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070150	114070150	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:114070150G>A	ENST00000462705.1	-	11	1377	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C	ZBTB20_ENST00000357258.3_Missense_Mutation_p.R186C|ZBTB20_ENST00000471418.1_Missense_Mutation_p.R186C|ZBTB20_ENST00000464560.1_Missense_Mutation_p.R186C|ZBTB20_ENST00000474710.1_Missense_Mutation_p.R259C|ZBTB20_ENST00000393785.2_Missense_Mutation_p.R186C|ZBTB20_ENST00000481632.1_Missense_Mutation_p.R186C	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TAAAAAGAGCGCTCGCCGCTG	0.642000													4	101					0	0	1	0	0
DCAF5	8816	broad.mit.edu	37	14	69520911	69520911	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:69520911T>C	ENST00000341516.5	-	9	2639	c.2492A>G	c.(2491-2493)aAc>aGc	p.N831S	DCAF5_ENST00000554215.1_Missense_Mutation_p.N749S|DCAF5_ENST00000556847.1_Missense_Mutation_p.N749S|DCAF5_ENST00000557386.1_Missense_Mutation_p.N830S	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	831						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						ATTGTTGTGGTTGGCACAGAT	0.592000													14	57					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024150	55024150	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:55024150A>G	ENST00000324000.3	+	3	2343	c.309A>G	c.(307-309)gaA>gaG	p.E103E		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	103					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TTAGGCAAGAAATTCTTCAGC	0.323000													3	27					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127669070	127669070	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:127669070C>T	ENST00000249363.3	-	2	1881	c.1624G>A	c.(1624-1626)Gcc>Acc	p.A542T	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	542						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		ATCAACATGGCGGCAGCTAGC	0.517000													9	20					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122612505	122612505	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:122612505G>A	ENST00000319080.6	+	3	728	c.596G>A	c.(595-597)cGc>cAc	p.R199H				Q9HAP2	MLXIP_HUMAN	MLX interacting protein	199	Required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GACGAGCACCGCCGGCCGGAG	0.607000													7	239					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85401778	85401778	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:85401778T>C	ENST00000258888.5	+	6	4582	c.4415T>C	c.(4414-4416)cTg>cCg	p.L1472P		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1472					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCAAAGACCTGCTGAAAGGT	0.617000													5	18					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11903761	11903761	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:11903761T>C	ENST00000405977.1	+	5	1641	c.1016T>C	c.(1015-1017)gTa>gCa	p.V339A	BTBD3_ENST00000378226.2_Missense_Mutation_p.V339A|BTBD3_ENST00000399006.2_Missense_Mutation_p.V278A|BTBD3_ENST00000254977.3_Missense_Mutation_p.V278A			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	339										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						CAGTCCGGGGTATTAACTCTC	0.473000													6	151					0	0	1	0	0
SLC22A3	6581	broad.mit.edu	37	6	160858095	160858095	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:160858095T>C	ENST00000392145.1	+	7	1167	c.1140T>C	c.(1138-1140)taT>taC	p.Y380Y	SLC22A3_ENST00000275300.2_Silent_p.Y380Y			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	380						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GCAACCTCTATATAGACTTTT	0.507000													10	199					0	0	1	0	0
DOLPP1	57171	broad.mit.edu	37	9	131846992	131846992	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131846992T>G	ENST00000372546.4	+	2	154	c.122T>G	c.(121-123)gTa>gGa	p.V41G	DOLPP1_ENST00000540102.1_5'UTR|DOLPP1_ENST00000406974.3_Missense_Mutation_p.V41G	NM_020438.4	NP_065171.2	Q86YN1	DOPP1_HUMAN	dolichyldiphosphatase 1	41					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			endometrium(3)|kidney(2)|lung(7)|skin(1)	13						CTCAGCCCTGTATTTGTCATC	0.577000													7	630					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67562997	67562997	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:67562997A>G	ENST00000280200.4	-	4	935	c.667T>C	c.(667-669)Tac>Cac	p.Y223H	CD226_ENST00000577287.1_Missense_Mutation_p.Y68H|CD226_ENST00000582621.1_Missense_Mutation_p.Y223H|CD226_ENST00000581982.1_Missense_Mutation_p.Y68H	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	223	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				GCCTGCAAGTAGCAGCGGTAA	0.527000													50	188					0	0	1	0	0
SPDEF	25803	broad.mit.edu	37	6	34506121	34506121	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:34506121T>C	ENST00000374037.3	-	6	1352	c.938A>G	c.(937-939)tAc>tGc	p.Y313C	SPDEF_ENST00000544425.1_Missense_Mutation_p.Y297C	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	313					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						GCCCTTCTTGTAATACTGGCG	0.612000													46	156					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116607106	116607106	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:116607106A>T	ENST00000369503.4	+	10	1472	c.1342A>T	c.(1342-1344)Att>Ttt	p.I448F		NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	448					ion transport	integral to membrane	transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGGTGGGATTATTGCTCCCTT	0.398000													12	29					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123314804	123314804	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:123314804T>C	ENST00000296513.2	+	6	775	c.590T>C	c.(589-591)gTa>gCa	p.V197A	ADAD1_ENST00000492454.1_3'UTR|ADAD1_ENST00000388725.2_Missense_Mutation_p.V179A|ADAD1_ENST00000388724.2_Missense_Mutation_p.V197A	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	197					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						GTTTCAAAAGTACATTATGGT	0.318000													8	44					0	0	1	0	0
CCDC151	115948	broad.mit.edu	37	19	11541547	11541547	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:11541547T>C	ENST00000356392.4	-	3	503	c.416A>G	c.(415-417)aAg>aGg	p.K139R	CCDC151_ENST00000586836.1_5'UTR|CCDC151_ENST00000545100.1_Missense_Mutation_p.K85R|CCDC151_ENST00000591179.1_Intron	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	139										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						CAGGTATGGCTTCTCCCACTT	0.577000													48	134					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437837	120437837	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:120437837A>G	ENST00000369400.1	-	1	1281	c.1123T>C	c.(1123-1125)Tat>Cat	p.Y375H		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	375	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AAAGAGATATAACTGCAATTG	0.398000													48	147					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48921859	48921859	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:48921859G>A	ENST00000310194.1	+	2	1053	c.1053G>A	c.(1051-1053)ctG>ctA	p.L351L	OR8S1_ENST00000551654.1_3'UTR	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	351					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						GCTCCGCGCTGCGCGCGGCGC	0.662000													4	26					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111679848	111679848	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:111679848G>T	ENST00000374647.5	-	9	1150	c.843C>A	c.(841-843)ccC>ccA	p.P281P	IKBKAP_ENST00000537196.1_5'UTR	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	281					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CTTTAAGGAAGGGAAGTGTAA	0.378000													27	86					6.36457e-07	6.52959e-07	1	1	0
TMEM62	80021	broad.mit.edu	37	15	43461855	43461855	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:43461855G>A	ENST00000260403.2	+	11	1640	c.1361G>A	c.(1360-1362)cGa>cAa	p.R454Q	TMEM62_ENST00000569369.1_3'UTR	NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	454						integral to membrane				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		TTTAGATATCGAGGATACCCA	0.378000													7	45					0	0	1	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33058778	33058778	+	Silent	SNP	C	C	T	rs144529739		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:33058778C>T	ENST00000373510.4	+	3	475	c.246C>T	c.(244-246)ttC>ttT	p.F82F	ZBTB8A_ENST00000316459.4_Silent_p.F82F|RP1-27O5.3_ENST00000480336.1_3'UTR	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	82	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F82F(1)		cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						TCTTGGACTTCGTATATTCTG	0.413000													35	129					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48517166	48517166	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:48517166G>A	ENST00000358350.4	-	56	8420	c.7816C>T	c.(7816-7818)Cca>Tca	p.P2606S	FRYL_ENST00000503238.1_Missense_Mutation_p.P2606S|FRYL_ENST00000264319.7_Missense_Mutation_p.P2S|FRYL_ENST00000537810.1_Missense_Mutation_p.P2606S|FRYL_ENST00000507873.2_Missense_Mutation_p.P2S	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	2606					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AGAGGCTCTGGCATTTCAGTT	0.403000													49	147					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40345097	40345097	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:40345097T>C	ENST00000280871.4	-	4	1046	c.996A>G	c.(994-996)ctA>ctG	p.L332L	SLC2A13_ENST00000380858.1_Silent_p.L332L	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	332						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				GGAACATTTGTAGGCCACAAC	0.368000										HNSCC(50;0.14)			11	90					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114133184	114133184	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:114133184A>G	ENST00000369615.1	+	5	904	c.842A>G	c.(841-843)gAc>gGc	p.D281G	MAGI3_ENST00000369617.4_Missense_Mutation_p.D281G|MAGI3_ENST00000369611.4_Missense_Mutation_p.D281G|MAGI3_ENST00000307546.9_Missense_Mutation_p.D281G	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	281	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCTCCATGGACTTTAGAAAT	0.408000													28	57					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140885038	140885038	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140885038G>A	ENST00000252085.3	+	3	2704	c.2562G>A	c.(2560-2562)gcG>gcA	p.A854A	PCDHGB4_ENST00000519479.1_Silent_p.A845A|PCDHGA7_ENST00000518325.1_Silent_p.A854A|PCDHGA11_ENST00000398587.2_Silent_p.A857A|PCDHGA5_ENST00000518069.1_Silent_p.A853A|PCDHGB6_ENST00000520790.1_Silent_p.A852A|PCDHGA10_ENST00000398610.2_Silent_p.A858A|PCDHGA1_ENST00000517417.1_Silent_p.A853A|PCDHGA8_ENST00000398604.2_Silent_p.A854A|PCDHGA11_ENST00000518882.1_Silent_p.A672A|PCDHGB7_ENST00000398594.2_Silent_p.A851A|PCDHGC5_ENST00000252087.1_Silent_p.A866A|PCDHGB3_ENST00000576222.1_Silent_p.A851A|PCDHGA2_ENST00000394576.2_Silent_p.A854A|PCDHGA9_ENST00000573521.1_Silent_p.A854A|PCDHGB1_ENST00000523390.1_Silent_p.A849A|PCDHGA4_ENST00000571252.1_Silent_p.A853A|PCDHGB2_ENST00000522605.1_Silent_p.A853A|PCDHGA3_ENST00000253812.6_Silent_p.A854A|PCDHGC4_ENST00000306593.1_Silent_p.A860A|PCDHGC3_ENST00000308177.3_Silent_p.A856A|PCDHGA6_ENST00000517434.1_Silent_p.A854A	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCTTGGCGTCCGCCAGTG	0.572000													38	152					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286262	48286262	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:48286262A>G	ENST00000320048.1	+	1	850	c.850A>G	c.(850-852)Att>Gtt	p.I284V		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						AAACCCTGTGATTTACTCCTT	0.408000													25	64					0	0	1	0	0
SIX2	10736	broad.mit.edu	37	2	45235822	45235822	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:45235822T>C	ENST00000303077.6	-	1	747	c.428A>G	c.(427-429)tAc>tGc	p.Y143C		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	143						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTTGTGCGCGTACCACTCGCG	0.657000													16	111					0	0	1	0	0
HOXC4	3221	broad.mit.edu	37	12	54448943	54448943	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:54448943C>T	ENST00000430889.2	+	2	795	c.749C>T	c.(748-750)gCc>gTc	p.A250V	HOXC4_ENST00000303406.4_Missense_Mutation_p.A250V	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	250						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						TCCCAGAGCGCCACGCCGCCG	0.647000													13	17					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103060455	103060455	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:103060455T>C	ENST00000375735.2	+	45	7491	c.7347T>C	c.(7345-7347)gtT>gtC	p.V2449V	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Silent_p.V2449V	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2449	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGGAACCAGTTCTACATAAAA	0.318000													5	102					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176218	8176218	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:8176218T>C	ENST00000520004.1	-	6	3931	c.3667A>G	c.(3667-3669)Acc>Gcc	p.T1223A	SGK223_ENST00000330777.4_Missense_Mutation_p.T1223A			Q86YV5	SG223_HUMAN		1223	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity										AGGTTTGGGGTGCCGCCCGGC	0.657000													11	60					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474737	120474737	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:120474737G>A	ENST00000355622.6	+	3	432	c.331G>A	c.(331-333)Gga>Aga	p.G111R	TLR4_ENST00000394487.4_Missense_Mutation_p.G71R|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	111					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity	p.G111*(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AATATTGACAGGAAACCCCAT	0.428000													14	45					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46500250	46500250	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:46500250C>T	ENST00000361297.2	+	29	4192	c.3909C>T	c.(3907-3909)agC>agT	p.S1303S	MAST2_ENST00000372009.2_Intron|MAST2_ENST00000372008.1_Intron	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1303					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CCAGCTCCAGCGTGCCCAGTT	0.597000													32	87					0	0	1	0	0
B4GALT5	9334	broad.mit.edu	37	20	48260136	48260136	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:48260136T>C	ENST00000371711.4	-	4	603	c.416A>G	c.(415-417)gAa>gGa	p.E139G		NM_004776.3	NP_004767.1	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	139					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			GGAGAAGAGTTCATGAATGTA	0.458000													25	90					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131149240	131149240	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:131149240T>C	ENST00000357668.1	-	13	1152	c.1125A>G	c.(1123-1125)gtA>gtG	p.V375V	ASAP1_ENST00000518721.1_Silent_p.V375V			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	375	PH.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						CATTAGGTTTTACTTGGCAGG	0.428000													36	166					0	0	1	0	0
DLL1	28514	broad.mit.edu	37	6	170597815	170597815	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:170597815A>G	ENST00000366756.3	-	3	746		c.e3+1			NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)						cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TTTTGTTTTTACCTGTTGCGA	0.498000													59	155					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	695069	695069	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:695069T>C	ENST00000304478.4	+	4	1129	c.1023T>C	c.(1021-1023)agT>agC	p.S341S		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	341					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		AGGTTCAGAGTTACGACTCGG	0.562000													10	107					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1045192	1045192	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:1045192C>T	ENST00000263094.6	+	12	1638	c.1407C>T	c.(1405-1407)gaC>gaT	p.D469D	ABCA7_ENST00000433129.1_Silent_p.D469D|ABCA7_ENST00000435683.2_Silent_p.D331D	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	469					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGCATGGACATTGACGTGG	0.652000													23	96					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28935292	28935292	+	Missense_Mutation	SNP	G	G	A	rs140838956		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:28935292G>A	ENST00000257192.4	+	15	3345	c.3133G>A	c.(3133-3135)Gtg>Atg	p.V1045M	DSG1_ENST00000462981.2_Missense_Mutation_p.V404M|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	1045					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GTATAGTACCGTGCAATATAG	0.438000													14	36					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10583449	10583449	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:10583449T>C	ENST00000304501.1	-	2	1044	c.966A>G	c.(964-966)gaA>gaG	p.E322E	SOX7_ENST00000554914.1_Silent_p.E374E|SOX7_ENST00000553390.1_Silent_p.E374E	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	322	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		CCCCCAGGAGTTCCACCTGGC	0.617000													17	60					0	0	1	0	0
PSMD1	5707	broad.mit.edu	37	2	231948419	231948419	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:231948419T>C	ENST00000308696.6	+	14	1826	c.1664T>C	c.(1663-1665)gTa>gCa	p.V555A	PSMD1_ENST00000409643.1_Missense_Mutation_p.V555A|PSMD1_ENST00000373635.4_Missense_Mutation_p.V555A	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	555					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	ATAGCTTTAGTAATGTATGGG	0.453000													24	67					0	0	1	0	0
ELK3	2004	broad.mit.edu	37	12	96640943	96640943	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:96640943T>C	ENST00000228741.3	+	3	759	c.433T>C	c.(433-435)Tcc>Ccc	p.S145P	ELK3_ENST00000552142.1_Intron	NM_005230.2	NP_005221.2	P41970	ELK3_HUMAN	ELK3, ETS-domain protein (SRF accessory protein 2)	145					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(5)|ovary(2)|prostate(1)|stomach(2)	20	all_cancers(2;0.00173)					CCTGTACTCGTCCTTCACCAT	0.627000													6	54					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72440247	72440247	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:72440247G>A	ENST00000305425.4	-	1	1083	c.661C>T	c.(661-663)Ctg>Ttg	p.L221L	DACH1_ENST00000354591.4_Silent_p.L221L|DACH1_ENST00000359684.2_Silent_p.L221L|DACH1_ENST00000313174.7_Silent_p.L221L	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	219	DACHbox-N.|Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AAGTGCTTCAGGAACAGGTCG	0.577000													4	109					0	0	1	0	0
DECR2	26063	broad.mit.edu	37	16	460246	460246	+	Missense_Mutation	SNP	C	C	T	rs141151070	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:460246C>T	ENST00000219481.5	+	5	479	c.341C>T	c.(340-342)gCg>gTg	p.A114V	DECR2_ENST00000424398.2_Missense_Mutation_p.A102V|DECR2_ENST00000461947.1_3'UTR|DECR2_ENST00000397710.1_Silent_p.C176C	NM_020664.3	NP_065715.1	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2, peroxisomal	114						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)	9		Hepatocellular(16;0.00015)				TCTGCAGGTGCGGCCGGGAAC	0.642000													6	21					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3980975	3980975	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:3980975A>G	ENST00000309311.6	-	8	1102	c.1014T>C	c.(1012-1014)gcT>gcC	p.A338A		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	338						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGCATCACAGCCTGCGGGG	0.647000													3	8					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179271879	179271879	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:179271879T>C	ENST00000367619.3	+	2	203	c.60T>C	c.(58-60)ccT>ccC	p.P20P	SOAT1_ENST00000540564.1_5'UTR|SOAT1_ENST00000535686.1_Intron|SOAT1_ENST00000539888.1_Intron	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	20					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	GGGAAAATCCTGAGGAAGATG	0.398000													10	87					0	0	1	0	0
ADD1	118	broad.mit.edu	37	4	2906672	2906672	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:2906672T>C	ENST00000355842.3	+	11	2206	c.1343T>C	c.(1342-1344)cTg>cCg	p.L448P	ADD1_ENST00000503455.2_Missense_Mutation_p.L448P|ADD1_ENST00000513328.2_Missense_Mutation_p.L448P|ADD1_ENST00000398129.1_Missense_Mutation_p.L448P|ADD1_ENST00000446856.1_Missense_Mutation_p.L448P|ADD1_ENST00000264758.7_Missense_Mutation_p.L448P|ADD1_ENST00000398123.2_Missense_Mutation_p.L448P|ADD1_ENST00000398125.1_Missense_Mutation_p.L448P			P35611	ADDA_HUMAN	adducin 1 (alpha)	448					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACAAGATGGCTGAACTCTGGC	0.542000													19	62					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	66980290	66980290	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:66980290T>C	ENST00000340001.4	-	35	4617	c.4406A>G	c.(4405-4407)aAc>aGc	p.N1469S	ABCA9_ENST00000453985.2_Missense_Mutation_p.N1431S|ABCA9_ENST00000370732.2_3'UTR	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1469	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					CCTCTCCGTGTTTCTAAAGGT	0.512000													4	99					0	0	1	0	0
GUCA1B	2979	broad.mit.edu	37	6	42153509	42153509	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:42153509G>A	ENST00000230361.3	-	3	479	c.384C>T	c.(382-384)tgC>tgT	p.C128C		NM_002098.5	NP_002089.4	Q9UMX6	GUC1B_HUMAN	guanylate cyclase activator 1B (retina)	128					body fluid secretion|cell-cell signaling|receptor guanylyl cyclase signaling pathway|visual perception	plasma membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			large_intestine(3)|lung(3)|skin(2)	8	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00154)|STAD - Stomach adenocarcinoma(11;0.00177)			GCTCTCGCCGGCAGGCTTTCT	0.562000													15	49					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87967022	87967022	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:87967022T>C	ENST00000369577.3	+	8	3718	c.3675T>C	c.(3673-3675)ggT>ggC	p.G1225G	ZNF292_ENST00000339907.4_Silent_p.G1220G	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AACAAGGTGGTATGTTATGTT	0.378000													8	26					0	0	1	0	0
NCF1	653361	broad.mit.edu	37	7	74197366	74197366	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:74197366C>T	ENST00000289473.4	+	6	606	c.536C>T	c.(535-537)aCg>aTg	p.T179M	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	179	SH3 1.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						GCTCTGTCCACGGGGGACGTG	0.637000													19	40					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71653961	71653961	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:71653961C>T	ENST00000409544.1	+	24	5592	c.4962C>T	c.(4960-4962)tgC>tgT	p.C1654C	ZNF638_ENST00000264447.4_Silent_p.C1654C|ZNF638_ENST00000355812.3_3'UTR|ZNF638_ENST00000409407.1_Silent_p.C594C	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1654					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AAGATGATTGCATTTCCCACA	0.348000													22	62					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18846122	18846122	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:18846122G>A	ENST00000412938.1	+	0	3480																											ACGCACTGGCGCACGATGTAG	0.617000													5	58					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172631485	172631485	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:172631485T>C	ENST00000351008.3	-	10	1736	c.1553A>G	c.(1552-1554)aAc>aGc	p.N518S		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	518					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TTCATTATTGTTTCTTCTTCC	0.363000													3	31					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038472	131038472	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131038472C>T	ENST00000320188.4	+	1	48	c.48C>T	c.(46-48)tgC>tgT	p.C16C		NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)	16					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										ACAAAAGCTGCGCACGCAACC	0.632000													33	98					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187372	123187372	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123187372G>A	ENST00000328880.5	-	1	518	c.459C>T	c.(457-459)ggC>ggT	p.G153G	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	153					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	CAATAGTGATGCCCCACAGAA	0.547000													5	147					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4833691	4833691	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:4833691C>T	ENST00000268231.8	-	6	852	c.589G>A	c.(589-591)Gac>Aac	p.D197N	SEPT12_ENST00000396693.5_Missense_Mutation_p.D151N	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	197					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						GTCAGGCTGTCGGCCCTGGCA	0.687000													22	69					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100190934	100190934	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:100190934G>A	ENST00000325103.6	-	7	855	c.622C>T	c.(622-624)Cat>Tat	p.H208Y	HPS1_ENST00000361490.4_Missense_Mutation_p.H208Y|HPS1_ENST00000467246.1_5'UTR|HPS1_ENST00000338546.5_Missense_Mutation_p.H208Y	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	208					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		AGGAAGGCATGCAGGGCCTCC	0.622000									Hermansky-Pudlak syndrome				11	31					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81654580	81654580	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:81654580C>G	ENST00000558726.1	-	4	510	c.375G>C	c.(373-375)atG>atC	p.M125I	TMC3_ENST00000359440.5_Missense_Mutation_p.M125I			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	125						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						TCTTTATCCTCATTTCCCAGG	0.483000													3	18					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33564173	33564173	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:33564173C>T	ENST00000321505.4	+	1	353	c.173C>T	c.(172-174)tCt>tTt	p.S58F	KIAA1549L_ENST00000265654.5_Missense_Mutation_p.S58F|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.S58F					KIAA1549-like																		TCCCATCCGTCTCCCCCTCCC	0.562000													5	112					0	0	1	0	0
HLCS	3141	broad.mit.edu	37	21	38308878	38308878	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:38308878G>A	ENST00000399120.1	-	5	2097	c.867C>T	c.(865-867)tgC>tgT	p.C289C	HLCS_ENST00000336648.3_Silent_p.C289C	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	289					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	CCTGGTACCTGCAGCCACTGC	0.582000													43	99					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109801625	109801625	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:109801625G>A	ENST00000271332.3	+	2	3943	c.3882G>A	c.(3880-3882)tcG>tcA	p.S1294S		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1294	EGF-like 2; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCTGCTACTCGCGGCCCTGTG	0.711000													9	25					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765467	47765467	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:47765467A>G	ENST00000273857.4	-	4	545	c.546T>C	c.(544-546)agT>agC	p.S182S	CORIN_ENST00000504584.1_Silent_p.S182S|CORIN_ENST00000502252.1_Silent_p.S115S|CORIN_ENST00000508498.1_Silent_p.S43S|CORIN_ENST00000505909.1_Silent_p.S182S	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	182	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GTTGATAGCAACTGAGGCGAT	0.473000													15	38					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27243970	27243970	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:27243970C>T	ENST00000429845.2	-	25	2531	c.2169G>A	c.(2167-2169)gcG>gcA	p.A723A	NEK10_ENST00000295720.6_Silent_p.A35A|NEK10_ENST00000383770.3_Silent_p.A35A|NEK10_ENST00000357467.2_Silent_p.A120A|NEK10_ENST00000383771.4_Silent_p.A35A			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	723							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GACTCAAAGTCGCCATCTGAT	0.488000													13	43					0	0	1	0	0
UBL4A	8266	broad.mit.edu	37	X	153713958	153713958	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153713958G>A	ENST00000369660.4	-	4	479	c.394C>T	c.(394-396)Ctg>Ttg	p.L132L	UBL4A_ENST00000369653.4_Silent_p.L132L|UBL4A_ENST00000477777.1_5'UTR	NM_014235.3	NP_055050.1	P11441	UBL4A_HUMAN	ubiquitin-like 4A	132					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity			endometrium(5)|lung(1)|urinary_tract(1)	7	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGTCGTCCAGCGTCAGGCGA	0.587000													61	43					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52966367	52966367	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52966367T>G	ENST00000549343.1	-	2	594	c.556A>C	c.(556-558)Aac>Cac	p.N186H	KRT74_ENST00000305620.2_Missense_Mutation_p.N186H			Q7RTS7	K2C74_HUMAN	keratin 74	186	Linker 1.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		GGCTCCAGGTTCTTCTTGCAG	0.557000													39	158					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24515341	24515341	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:24515341C>T	ENST00000398319.2	+	28	4693	c.4308C>T	c.(4306-4308)aaC>aaT	p.N1436N	CABIN1_ENST00000263119.5_Silent_p.N1436N|CABIN1_ENST00000405822.2_Silent_p.N1357N	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1436					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TAGGAAAAAACGAGGAGTCAT	0.547000													12	56					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120354158	120354158	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:120354158T>C	ENST00000239032.2	-	2	737	c.599A>G	c.(598-600)cAc>cGc	p.H200R	PRLHR_ENST00000369169.1_Missense_Mutation_p.H200R	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	200					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GAGCTCCACGTGATAGGTGTG	0.716000													3	23					0	0	1	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101576014	101576014	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:101576014T>C	ENST00000326172.5	+	10	2037	c.1922T>C	c.(1921-1923)tTt>tCt	p.F641S	NFKBIZ_ENST00000394054.2_Missense_Mutation_p.F541S|NFKBIZ_ENST00000326151.5_Missense_Mutation_p.F519S	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	641	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						TGCCTGTCTTTTGTGAATGCA	0.478000													15	74					0	0	1	0	0
DQX1	165545	broad.mit.edu	37	2	74750494	74750494	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:74750494G>A	ENST00000404568.3	-	5	1206	c.987C>T	c.(985-987)ttC>ttT	p.F329F	DQX1_ENST00000393951.2_Silent_p.F329F|DQX1_ENST00000495597.1_5'UTR	NM_133637.2	NP_598376.2	Q8TE96	DQX1_HUMAN	DEAQ box RNA-dependent ATPase 1	329	Helicase C-terminal.					nucleus	ATP binding|helicase activity|nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	18						GGGAGAAGGAGAAGTCAGCCA	0.547000													87	302					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45457779	45457779	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45457779T>C	ENST00000291574.4	+	3	431	c.256T>C	c.(256-258)Ttc>Ctc	p.F86L	TRAPPC10_ENST00000380221.3_Missense_Mutation_p.F86L	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	86					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						CACGTTTCCCTTCCTCCATAT	0.522000													44	114					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154515221	154515221	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:154515221G>A	ENST00000368482.4	+	8	1265	c.427G>A	c.(427-429)Gct>Act	p.A143T	TDRD10_ENST00000479937.1_3'UTR|TDRD10_ENST00000368480.3_Missense_Mutation_p.A143T	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	143							nucleotide binding|RNA binding	p.A143T(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TATACAGCTCGCTCCTAAAGC	0.512000													7	70					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67264368	67264368	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67264368G>A	ENST00000258201.4	-	19	3147	c.2900C>T	c.(2899-2901)gCg>gTg	p.A967V	FHOD1_ENST00000567687.1_Missense_Mutation_p.A546V	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	967	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TTCACGGGCCGCCTGCGGGGT	0.592000													34	99					0	0	1	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27834914	27834914	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:27834914T>C	ENST00000331442.3	-	1	445	c.394A>G	c.(394-396)Aag>Gag	p.K132E		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	132					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						GCGGGCTTCTTAGCTTTAGCG	0.612000													68	202					0	0	1	0	0
PKD2L2	27039	broad.mit.edu	37	5	137241900	137241900	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:137241900T>C	ENST00000508638.1	+	6	807	c.752T>C	c.(751-753)gTg>gCg	p.V251A	PKD2L2_ENST00000502810.1_Missense_Mutation_p.V251A|PKD2L2_ENST00000508883.1_Missense_Mutation_p.V251A|PKD2L2_ENST00000350250.4_Missense_Mutation_p.V217A|PKD2L2_ENST00000290431.5_Missense_Mutation_p.V251A	NM_001258449.1	NP_001245378.1	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	251						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TACAGATTGGTGGCAGAATTC	0.343000													27	60					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42477017	42477017	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:42477017G>A	ENST00000434000.1	-	9	2476	c.2194C>T	c.(2194-2196)Cgg>Tgg	p.R732W	GPATCH8_ENST00000591680.1_Missense_Mutation_p.R810W			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	810						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GGTTGGCTCCGATGGCTAGAC	0.552000													31	87					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35555441	35555441	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35555441C>T	ENST00000455600.1	+	3	2968	c.2399C>T	c.(2398-2400)tCg>tTg	p.S800L		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	800						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCCTCCACTTCGTGCTCCCCT	0.667000													86	199					0	0	1	0	0
FASTKD3	79072	broad.mit.edu	37	5	7863000	7863000	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:7863000A>G	ENST00000264669.5	-	4	1771	c.1635T>C	c.(1633-1635)acT>acC	p.T545T	FASTKD3_ENST00000513658.1_5'UTR|MTRR_ENST00000502509.1_Intron	NM_024091.3	NP_076996.2	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	545					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CTAAAAGGTTAGTCAGCCCAA	0.373000													8	253					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62865264	62865264	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:62865264A>G	ENST00000584306.1	-	8	3457	c.2927T>C	c.(2926-2928)cTg>cCg	p.L976P	LRRC37A3_ENST00000339474.5_Missense_Mutation_p.L94P|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.L14P|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.L976P	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	976						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						AACAGTTGTCAGAGGATTGTG	0.299000													32	131					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180952	168180952	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:168180952G>A	ENST00000519560.1	-	17	2165	c.1746C>T	c.(1744-1746)agC>agT	p.S582S	SLIT3_ENST00000404867.3_Silent_p.S582S|SLIT3_ENST00000332966.8_Silent_p.S582S	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	582					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTCCTGCACGCTGGCTGCTC	0.552000													10	31					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26778441	26778441	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:26778441C>T	ENST00000345317.2	-	6	755	c.442G>A	c.(442-444)Gta>Ata	p.V148I	SKAP2_ENST00000489977.1_5'UTR|SKAP2_ENST00000539623.1_5'UTR	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	148	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						TAATAGAATACCGTTTTACTG	0.383000													15	79					0	0	1	0	0
TRMU	55687	broad.mit.edu	37	22	46752902	46752902	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46752902G>A	ENST00000290846.4	+	11	1605	c.1265G>A	c.(1264-1266)tGa>tAa	p.*422*	TRMU_ENST00000381019.3_3'UTR	NM_018006.4	NP_060476.2	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	0						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)	10		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		CCCTTGCTCTGACAGAGATGG	0.627000													17	49					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56698986	56698986	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:56698986A>G	ENST00000260129.5	+	4	1006	c.529A>G	c.(529-531)Act>Gct	p.T177A		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	177					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CAAAAAAGATACTGAGACAGA	0.343000													21	88					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79360054	79360054	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:79360054A>G	ENST00000264895.6	+	40	5806		c.e40-1		FRAS1_ENST00000325942.6_Splice_Site	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1						cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GTTTTTTTATAGATACTCAGC	0.363000													17	84					0	0	1	0	0
NDUFA3	4696	broad.mit.edu	37	19	54611747	54611747	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54611747C>T	ENST00000391764.3	+	4	174	c.163_splice	c.e4-1	p.A55_splice	TFPT_ENST00000391758.1_Intron|TFPT_ENST00000391757.1_Intron|TFPT_ENST00000391759.1_Intron			O95167	NDUA3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	55					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)	2	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)				NADH(DB00157)	TATCTCCTAGCGGCTGGGGAA	0.597000													13	42					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140911612	140911612	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:140911612T>C	ENST00000277550.3	+	3	162	c.162T>C	c.(160-162)ggT>ggC	p.G54G	CACNA1B_ENST00000371357.1_Intron|CACNA1B_ENST00000277551.2_Intron|CACNA1B_ENST00000277549.5_Intron|CACNA1B_ENST00000371363.1_Intron|CACNA1B_ENST00000371372.1_Intron|CACNA1B_ENST00000371355.4_Intron			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	761					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AAGCTCGAGGTACTGTATCTC	0.473000													4	37					0	0	1	0	0
ING1	3621	broad.mit.edu	37	13	111371616	111371616	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:111371616T>C	ENST00000375774.3	+	2	1068	c.606T>C	c.(604-606)agT>agC	p.S202S	ING1_ENST00000464141.1_3'UTR|ING1_ENST00000338450.7_Silent_p.S15S|ING1_ENST00000333219.7_Silent_p.S59S|ING1_ENST00000375775.3_5'UTR	NM_005537.4	NP_005528.3	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1	202					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			endometrium(4)|large_intestine(6)|lung(1)|ovary(1)	12	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			AGCGCTTCAGTCGCGAGACAG	0.647000													35	89					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108032395	108032395	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:108032395T>C	ENST00000278612.8	-	17	3523	c.3418A>G	c.(3418-3420)Acc>Gcc	p.T1140A		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	1140					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TCTCTTATGGTGGTATGCCGG	0.373000													8	95					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144124506	144124506	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144124506T>C	ENST00000395172.1	+	2	438		c.e2+2		C8orf31_ENST00000517653.1_Intron	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31											breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GGACAGAGGGTAGGCCTGCGG	0.612000													23	108					0	0	1	0	0
HSPBAP1	79663	broad.mit.edu	37	3	122487712	122487712	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:122487712T>C	ENST00000383659.1	-	3	390	c.268A>G	c.(268-270)Aca>Gca	p.T90A	HSPBAP1_ENST00000306103.2_Missense_Mutation_p.T90A|HSPBAP1_ENST00000465044.1_5'UTR			Q96EW2	HBAP1_HUMAN	HSPB (heat shock 27kDa) associated protein 1	90	Interaction with HSPB1 (By similarity).					cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(114;0.0531)		TAATTACATGTAGTTTCAAAC	0.318000													9	32					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23225645	23225645	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:23225645C>T	ENST00000389131.3	-	2	589	c.220G>A	c.(220-222)Gtg>Atg	p.V74M		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	74	SRCR 1.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TCATAGTACACCTCCACCCGG	0.657000													33	113					0	0	1	0	0
WNT9B	7484	broad.mit.edu	37	17	44954067	44954067	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:44954067T>C	ENST00000290015.2	+	4	1110	c.1057T>C	c.(1057-1059)Tac>Cac	p.Y353H	WNT9B_ENST00000393461.2_Intron	NM_003396.1	NP_003387.1	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	353					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GGAGCTTGTGTACACCTGCAA	0.632000													6	33					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137501707	137501707	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:137501707A>G	ENST00000254900.5	-	11	1459	c.1088T>C	c.(1087-1089)aTc>aCc	p.I363T	BRD8_ENST00000230901.5_Missense_Mutation_p.I436T|BRD8_ENST00000455658.2_Missense_Mutation_p.I322T|BRD8_ENST00000411594.2_Missense_Mutation_p.I366T|BRD8_ENST00000402931.1_Missense_Mutation_p.I363T	NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	363					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AGAATTGATGATCATGGATAT	0.468000													6	157					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57256751	57256751	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:57256751G>T	ENST00000278426.3	-	12	1663	c.1308C>A	c.(1306-1308)acC>acA	p.T436T	SLC43A1_ENST00000528450.1_Silent_p.T436T	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	436					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						TGATGAGACAGGTGATGCCAA	0.552000													36	84					4.62619e-21	4.88158e-21	1	1	0
TAF9	6880	broad.mit.edu	37	5	68660866	68660866	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:68660866T>C	ENST00000328663.4	-	3	1165	c.699A>G	c.(697-699)tcA>tcG	p.S233S	TAF9_ENST00000380818.3_Intron|TAF9_ENST00000506736.1_Silent_p.S233S|TAF9_ENST00000502819.1_Intron|TAF9_ENST00000380822.4_Intron|TAF9_ENST00000217893.5_Silent_p.S233S|TAF9_ENST00000512561.1_Intron	NM_001015892.1	NP_001015892.1	Q9Y3D8	KAD6_HUMAN	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	0						Cajal body	adenylate kinase activity|ATP binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	8		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		CAGTATTTTGTGATGACATCA	0.338000													16	56					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79661856	79661856	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:79661856G>A	ENST00000329138.4	+	12	1083	c.948G>A	c.(946-948)gcG>gcA	p.A316A		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	316	Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			ACTCGTCGGCGCCTCTGGCTG	0.612000													4	117					0	0	1	0	0
ERAP1	51752	broad.mit.edu	37	5	96112181	96112181	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:96112181A>G	ENST00000296754.3	-	19	3002	c.2745T>C	c.(2743-2745)atT>atC	p.I915I	ERAP1_ENST00000443439.2_Silent_p.I915I	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	915					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		TGTTTTCTTCAATGGTTTCAA	0.383000													13	95					0	0	1	0	0
SLC44A1	23446	broad.mit.edu	37	9	108123609	108123609	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:108123609A>G	ENST00000374720.3	+	8	1145	c.898A>G	c.(898-900)Aca>Gca	p.T300A	SLC44A1_ENST00000374723.1_Missense_Mutation_p.T300A|SLC44A1_ENST00000343170.7_Missense_Mutation_p.T92A|SLC44A1_ENST00000374724.1_Missense_Mutation_p.T300A	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	300						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	TACAGTGTTCACAGTGAGTTT	0.428000													30	101					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18149520	18149520	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:18149520T>C	ENST00000375406.1	+	2	233	c.17T>C	c.(16-18)gTt>gCt	p.V6A		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	6						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GCAAGAACCGTTATCATTGAC	0.577000													8	32					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151128335	151128335	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:151128335T>C	ENST00000370325.1	-	6	813	c.760A>G	c.(760-762)Act>Gct	p.T254A	GABRE_ENST00000393914.3_Missense_Mutation_p.T61A|GABRE_ENST00000370328.3_Missense_Mutation_p.T254A			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	254					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					ATTATTTCAGTTTTGTTGCTC	0.443000													44	44					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140752069	140752069	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140752069T>A	ENST00000576222.1	+	1	2239	c.2108T>A	c.(2107-2109)tTc>tAc	p.F703Y	PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGTGCTCTTCCTCCTCGCG	0.582000													6	165					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241808594	241808594	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:241808594A>G	ENST00000307503.3	+	2	560	c.173A>G	c.(172-174)gAc>gGc	p.D58G		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	58					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CAGATCATGGACGAGATCAAG	0.622000													5	119					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41364187	41364187	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:41364187T>C	ENST00000361937.3	-	12	1889	c.1465A>G	c.(1465-1467)Act>Gct	p.T489A	INO80_ENST00000401393.3_Missense_Mutation_p.T489A			Q9ULG1	INO80_HUMAN	INO80 complex subunit	489	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CCAAACCCAGTGCCAGACTTG	0.423000													11	128					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160098602	160098602	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:160098602A>T	ENST00000361216.3	+	9	1267	c.1178A>T	c.(1177-1179)aAc>aTc	p.N393I	ATP1A2_ENST00000392233.3_Missense_Mutation_p.N393I|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	393					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGGTTCGACAACCAAATCCAT	0.612000													27	67					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90322130	90322130	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:90322130G>A	ENST00000469640.2	+	27	4594	c.4219G>A	c.(4219-4221)Gag>Aag	p.E1407K	DAPK1_ENST00000472284.1_Missense_Mutation_p.E1382K|DAPK1_ENST00000408954.3_Missense_Mutation_p.E1382K|DAPK1_ENST00000358077.5_Missense_Mutation_p.E1382K|DAPK1_ENST00000491893.1_Missense_Mutation_p.E1316K			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1382					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						CAAACTGAGGGAGCTGGGTCG	0.607000									Chronic Lymphocytic Leukemia, Familial Clustering of				9	35					0	0	1	0	0
DCAF16	54876	broad.mit.edu	37	4	17805713	17805713	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:17805713C>A	ENST00000382247.1	-	3	1112	c.52G>T	c.(52-54)Gaa>Taa	p.E18*	DCAF16_ENST00000536863.1_Nonsense_Mutation_p.E18*	NM_017741.3	NP_060211.3	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	18	Poly-Glu.					CUL4 RING ubiquitin ligase complex				cervix(1)|endometrium(1)|lung(2)|ovary(1)	5						TTTTCTTCTTCCTCACTTTCT	0.423000													7	38					0.00307968	0.00310584	1	1	0
CMYA5	202333	broad.mit.edu	37	5	79033127	79033127	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:79033127A>G	ENST00000446378.2	+	2	8570	c.8539A>G	c.(8539-8541)Aca>Gca	p.T2847A		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2847						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAAGGCATACAGTTCATAC	0.423000													34	78					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233408002	233408002	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233408002A>G	ENST00000389494.3	+	8	844	c.823A>G	c.(823-825)Acc>Gcc	p.T275A	CHRNG_ENST00000389492.3_Missense_Mutation_p.T223A	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	275					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCAGAAGTGTACCGTCGCCAT	0.597000													14	50					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143185960	143185960	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:143185960G>A	ENST00000316549.6	-	12	1596	c.1388C>T	c.(1387-1389)aCc>aTc	p.T463I		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	463					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						CAGCGTAGTGGTAAACATCAT	0.478000													18	39					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318466	48318466	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48318466T>C	ENST00000435803.1	+	18	7699	c.7675T>C	c.(7675-7677)Tat>Cat	p.Y2559H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2559					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGACACTCTGTATTCCATCAT	0.318000													41	115					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711277	192711277	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:192711277C>T	ENST00000304141.4	-	1	704	c.375G>A	c.(373-375)acG>acA	p.T125T	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	125						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGACCGCGCGCGTGTGGGCGC	0.602000													27	50					0	0	1	0	0
RBM38	55544	broad.mit.edu	37	20	55982757	55982757	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:55982757A>G	ENST00000356208.5	+	4	750	c.575A>G	c.(574-576)tAc>tGc	p.Y192C	RBM38_ENST00000371219.2_Missense_Mutation_p.Y111C|RBM38_ENST00000440234.2_3'UTR	NM_017495.5	NP_059965.2	Q9H0Z9	RBM38_HUMAN	RNA binding motif protein 38	192					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding			large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			CAGTACCCATACGCCGCCTCG	0.706000													14	47					0	0	1	0	0
CMIP	80790	broad.mit.edu	37	16	81730216	81730216	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:81730216C>T	ENST00000537098.3	+	14	1654	c.1582C>T	c.(1582-1584)Ctc>Ttc	p.L528F	CMIP_ENST00000539778.2_Missense_Mutation_p.L434F|CMIP_ENST00000566513.1_3'UTR|CMIP_ENST00000398040.4_Missense_Mutation_p.L375F	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	494						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						CTGGTTCCAGCTCTACAGCCC	0.652000													4	52					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132527055	132527055	+	Silent	SNP	G	G	A	rs144949245		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:132527055G>A	ENST00000331898.7	-	2	905	c.327C>T	c.(325-327)gaC>gaT	p.D109D	OPCML_ENST00000524381.1_Silent_p.D102D|OPCML_ENST00000374778.4_Silent_p.D68D|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000541867.1_Silent_p.D109D	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	109	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ACGGACCTTCGTCATACACAT	0.507000													25	64					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27216987	27216987	+	Missense_Mutation	SNP	G	G	A	rs145240806		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:27216987G>A	ENST00000230582.3	+	4	461	c.446G>A	c.(445-447)cGc>cAc	p.R149H	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	149					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GCCCAGCTCCGCTTCTTGTCC	0.562000													30	117					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235403679	235403679	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:235403679A>G	ENST00000264183.3	-	8	1031	c.534T>C	c.(532-534)tgT>tgC	p.C178C	ARID4B_ENST00000349213.3_Silent_p.C178C|ARID4B_ENST00000366603.2_Silent_p.C178C	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TGTAATCTACACATACAACTT	0.368000													12	23					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77379267	77379267	+	Nonsense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:77379267T>A	ENST00000334955.7	+	3	1257	c.1230T>A	c.(1228-1230)taT>taA	p.Y410*	RSBN1L_ENST00000445288.1_Nonsense_Mutation_p.Y140*	NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	410						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CAGCTACTTATTTACCTGACT	0.378000													40	146					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603663	138603663	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:138603663G>A	ENST00000440172.1	-	2	757	c.709C>T	c.(709-711)Cgc>Tgc	p.R237C	KIAA1549_ENST00000242365.4_Missense_Mutation_p.R187C|KIAA1549_ENST00000422774.1_Missense_Mutation_p.R237C	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	237						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCAGAGGTGCGAAAAGCTGAC	0.502000			O	BRAF	pilocytic astrocytoma								36	118					0	0	1	0	0
MTMR10	54893	broad.mit.edu	37	15	31253111	31253111	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:31253111A>G	ENST00000435680.1	-	7	828	c.731T>C	c.(730-732)aTt>aCt	p.I244T	MTMR10_ENST00000314404.8_5'UTR|MTMR10_ENST00000563714.1_Missense_Mutation_p.I162T|MTMR10_ENST00000425768.1_Silent_p.L214L	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	244	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		ACCCTCGTTAATAGAACAAAC	0.423000													5	22					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891802	44891802	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:44891802T>C	ENST00000330997.4	-	4	669	c.605A>G	c.(604-606)gAc>gGc	p.D202G	ZNF285_ENST00000591679.1_Missense_Mutation_p.D209G|ZNF285_ENST00000544719.2_Missense_Mutation_p.D202G|CTC-512J12.6_ENST00000588212.1_Intron	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TCTACCAGGGTCCTCTCCTTT	0.443000													27	95					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35786521	35786521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:35786521C>T	ENST00000361922.4	+	4	202	c.52C>T	c.(52-54)Cga>Tga	p.R18*	MAG_ENST00000537831.2_5'UTR|MAG_ENST00000597035.1_Nonsense_Mutation_p.R18*|MAG_ENST00000392213.3_Nonsense_Mutation_p.R18*	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	18					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CGCAGCCTCCCGAGGGGGTCA	0.687000													37	75					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138260997	138260997	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:138260997G>A	ENST00000302763.7	+	13	1890	c.1800G>A	c.(1798-1800)tcG>tcA	p.S600S	CTNNA1_ENST00000355078.5_Silent_p.S497S|CTNNA1_ENST00000540387.1_Silent_p.S230S|CTNNA1_ENST00000518825.1_Silent_p.S600S	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	600					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding	p.S600S(1)		NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCCTCAGCTCGGACCCTGCCC	0.537000													31	54					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145304609	145304609	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:145304609A>G	ENST00000342960.5	+	10	1577	c.1542A>G	c.(1540-1542)tcA>tcG	p.S514S	NBPF10_ENST00000369339.2_Silent_p.S243S|NBPF10_ENST00000369338.1_Silent_p.S243S|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	514										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCATTGGCTCATCCTCTCATG	0.428000													7	485					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72840621	72840621	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:72840621A>G	ENST00000293190.5	-	12	2523	c.2377T>C	c.(2377-2379)Tgg>Cgg	p.W793R	GRIN2C_ENST00000347612.4_Missense_Mutation_p.W793R	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	793					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CCTGAGAGCCACACTGTCTCC	0.542000													34	76					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56362809	56362809	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:56362809C>T	ENST00000370754.5	-	81	19845	c.19846G>A	c.(19846-19848)Gcc>Acc	p.A6616T	DST_ENST00000370769.4_Missense_Mutation_p.A6438T|DST_ENST00000312431.6_3'UTR|DST_ENST00000421834.2_Missense_Mutation_p.A4350T|DST_ENST00000370788.2_Missense_Mutation_p.A4241T|DST_ENST00000446842.2_Missense_Mutation_p.A6112T|DST_ENST00000361203.3_Missense_Mutation_p.A6327T|DST_ENST00000244364.6_Missense_Mutation_p.A4024T|DST_ENST00000340834.4_5'UTR			Q03001	DYST_HUMAN	dystonin	6436					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTATTAACGGCTTCCACTGTG	0.368000													35	142					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10415172	10415172	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10415172C>T	ENST00000226207.5	-	14	1494	c.1400G>A	c.(1399-1401)gGc>gAc	p.G467D	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	467	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GATCTCAAAGCCAGCAATGTC	0.458000													53	167					0	0	1	0	0
PIGK	10026	broad.mit.edu	37	1	77685039	77685039	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:77685039C>T	ENST00000370812.3	-	1	72	c.49G>A	c.(49-51)Gtg>Atg	p.V17M	PIGK_ENST00000445065.1_Missense_Mutation_p.V17M|PIGK_ENST00000478391.1_5'UTR|PIGK_ENST00000370813.5_Missense_Mutation_p.V17M|PIGK_ENST00000359130.1_Missense_Mutation_p.V17M	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	17					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						AAGAGCAACACAGTTGCCAAG	0.622000													11	46					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35582000	35582000	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:35582000T>C	ENST00000353139.5	-	27	3868	c.3387A>G	c.(3385-3387)tcA>tcG	p.S1129S	ACACA_ENST00000394406.2_Silent_p.S1092S|ACACA_ENST00000360679.3_Silent_p.S1034S|ACACA_ENST00000335166.5_Silent_p.S1014S	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1092					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAAGCTCATATGATGGCAAAT	0.398000													6	71					0	0	1	0	0
RAD18	56852	broad.mit.edu	37	3	8955357	8955357	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:8955357G>A	ENST00000264926.2	-	8	1053	c.937C>T	c.(937-939)Cgt>Tgt	p.R313C		NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	313					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		GCTTCAAGACGCATCCTAGTC	0.308000								Rad6 pathway					5	27					0	0	1	0	0
ASTE1	28990	broad.mit.edu	37	3	130744027	130744027	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:130744027T>C	ENST00000264992.3	-	3	565	c.124A>G	c.(124-126)Agt>Ggt	p.S42G	ASTE1_ENST00000514044.1_Missense_Mutation_p.S42G	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	42					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						AAGTTTGAACTGAAGCAAAGA	0.373000													36	138					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17292528	17292528	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17292528G>A	ENST00000375541.5	+	29	4679	c.4610G>A	c.(4609-4611)cGc>cAc	p.R1537H		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1537					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCCCTGAATCGCCAGCTGGCC	0.632000													21	73					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	8989584	8989584	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:8989584A>G	ENST00000344836.4	-	27	3032	c.2834T>C	c.(2833-2835)gTa>gCa	p.V945A	USP7_ENST00000535863.1_Missense_Mutation_p.V846A|USP7_ENST00000381886.4_Missense_Mutation_p.V929A	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	945					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						TTTGTAGCTTACAATTTCTAG	0.338000													9	27					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554213	140554213	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140554213C>T	ENST00000231137.3	+	1	1971	c.1797C>T	c.(1795-1797)aaC>aaT	p.N599N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		599	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGGCCAGAACGCCTGGCTGT	0.711000													42	492					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160394995	160394995	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:160394995G>A	ENST00000368061.2	+	8	1867	c.1393G>A	c.(1393-1395)Gag>Aag	p.E465K		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	465					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane		p.E465K(1)		biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATTGGTGAGCGAGGAGCCGGT	0.552000													9	45					0	0	1	0	0
IFRD2	7866	broad.mit.edu	37	3	50330103	50330103	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:50330103T>C	ENST00000336089.4	-	2	201	c.202A>G	c.(202-204)Acc>Gcc	p.T68A	IFRD2_ENST00000436390.1_5'UTR			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	0							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGCACGGTGGTTAACTCCGAA	0.672000													5	101					0	0	1	0	0
ACAD11	84129	broad.mit.edu	37	3	132360899	132360899	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:132360899T>C	ENST00000264990.6	-	4	1425	c.454A>G	c.(454-456)Aca>Gca	p.T152A	ACAD11_ENST00000355458.3_Missense_Mutation_p.T152A|ACAD11_ENST00000481970.2_Missense_Mutation_p.T152A|ACAD11_ENST00000545291.1_5'UTR|ACAD11_ENST00000489991.1_Intron	NM_032169.4	NP_115545.3			acyl-CoA dehydrogenase family, member 11											breast(2)|endometrium(6)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	36						TGAGCCAATGTTTCTACCGTG	0.443000													33	110					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186113680	186113680	+	Missense_Mutation	SNP	C	C	T	rs41317503	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:186113680C>T	ENST00000271588.4	+	91	14340	c.14111C>T	c.(14110-14112)gCg>gTg	p.A4704V	HMCN1_ENST00000367492.2_Missense_Mutation_p.A4704V	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4704	TSP type-1 4.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGCAAGTGGGCGACTTGGGCC	0.517000													9	232					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735666	140735666	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140735666A>G	ENST00000571252.1	+	1	899	c.899A>G	c.(898-900)gAt>gGt	p.D300G	PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAGTGGGGATATAACAATA	0.438000													12	34					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84900593	84900593	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:84900593C>T	ENST00000262424.5	+	7	1024	c.800C>T	c.(799-801)cCg>cTg	p.P267L	CRISPLD2_ENST00000567845.1_Missense_Mutation_p.P266L|CRISPLD2_ENST00000564567.1_Missense_Mutation_p.P267L	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	267						extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						TGGCTCCAACCGAGGGTGATG	0.537000													24	77					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241534605	241534605	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:241534605C>T	ENST00000391984.2	+	7	1358	c.1162C>T	c.(1162-1164)Cac>Tac	p.H388Y	CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Missense_Mutation_p.H388Y|CAPN10_ENST00000404753.3_Missense_Mutation_p.H388Y|CAPN10_ENST00000391982.2_Missense_Mutation_p.H388Y	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	388	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		ATCCAGGCTGCACGCGGCGGA	0.647000													30	93					0	0	1	0	0
SPDEF	25803	broad.mit.edu	37	6	34512036	34512036	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:34512036A>G	ENST00000374037.3	-	2	611	c.197T>C	c.(196-198)cTg>cCg	p.L66P	SPDEF_ENST00000544425.1_Missense_Mutation_p.L66P	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	66					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						CTCAGGGTACAGCATGTCAAA	0.667000													23	77					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027420	37027420	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:37027420T>C	ENST00000358047.3	+	1	989	c.937T>C	c.(937-939)Tca>Cca	p.S313P		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	313										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GCCTCCCAAGTCACGCGTATC	0.602000													48	36					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79741121	79741121	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:79741121A>G	ENST00000338008.5	+	6	2801	c.2621A>G	c.(2620-2622)gAt>gGt	p.D874G	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.D874G|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.D874G	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	874					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TGGTTTGCAGATGGTATATTG	0.358000													19	65					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33631336	33631336	+	Nonsense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:33631336T>G	ENST00000321505.4	+	14	4392	c.4212T>G	c.(4210-4212)taT>taG	p.Y1404*	KIAA1549L_ENST00000389726.3_Nonsense_Mutation_p.Y1410*					KIAA1549-like																		TCGAGCACTATCGGAACAAGC	0.547000													6	25					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18523805	18523805	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:18523805C>T	ENST00000336714.3	+	14	2086	c.1654C>T	c.(1654-1656)Ctc>Ttc	p.L552F	SEC23B_ENST00000262544.2_Missense_Mutation_p.L552F|SEC23B_ENST00000377475.3_Missense_Mutation_p.L552F|SEC23B_ENST00000377465.1_Missense_Mutation_p.L552F	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	552					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						GGACCGACAACTCATCCGACT	0.502000													37	137					0	0	1	0	0
MTFR2	113115	broad.mit.edu	37	6	136564004	136564004	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:136564004T>A	ENST00000420702.1	-	4	665	c.276A>T	c.(274-276)agA>agT	p.R92S	MTFR2_ENST00000451457.2_Missense_Mutation_p.R92S	NM_001099286.1	NP_001092756.1			mitochondrial fission regulator 2																		ATTACCGAAATCTGAGATAAC	0.358000													9	46					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64643562	64643562	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:64643562A>G	ENST00000371079.1	+	9	2213	c.1838A>G	c.(1837-1839)cAc>cGc	p.H613R	ROR1_ENST00000545203.1_Missense_Mutation_p.H64R	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	613	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						TTCTTTGTCCACAAGGACCTT	0.448000													23	54					0	0	1	0	0
RND3	390	broad.mit.edu	37	2	151328152	151328152	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:151328152A>T	ENST00000375734.2	-	4	721	c.472T>A	c.(472-474)Tcc>Acc	p.S158T	RND3_ENST00000409557.1_Missense_Mutation_p.S29T|RND3_ENST00000472416.1_5'UTR|RND3_ENST00000263895.4_Missense_Mutation_p.S158T	NM_001254738.1	NP_001241667.1	P61587	RND3_HUMAN	Rho family GTPase 3	158					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.106)		TGGTCATAGGACACTGGCGTC	0.403000													22	89					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712134	140712134	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140712134C>T	ENST00000517417.1	+	1	1883	c.1883C>T	c.(1882-1884)aCg>aTg	p.T628M	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.T628M	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGTGCGCACGGCGCGAGCC	0.697000													31	91					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149677774	149677774	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:149677774A>G	ENST00000328668.7	-	2	1292	c.713T>C	c.(712-714)gTa>gCa	p.V238A		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	238						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTGTGTGTACTGCCTGGAA	0.622000													16	61					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800482	27800482	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27800482C>T	ENST00000408964.2	+	1	1094	c.1043C>T	c.(1042-1044)tCa>tTa	p.S348L		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	348										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GATTCTGCTTCAGGGATGACA	0.443000													25	83					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69874094	69874094	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:69874094G>A	ENST00000359154.2	+	5	507	c.406G>A	c.(406-408)Gag>Aag	p.E136K	WWP2_ENST00000356003.2_Missense_Mutation_p.E136K|WWP2_ENST00000569174.1_Missense_Mutation_p.E136K|WWP2_ENST00000448661.1_Missense_Mutation_p.E136K|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000542271.1_Missense_Mutation_p.E20K	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	136				E -> K (in Ref. 1; AAC51325).	entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTCAGGCGGAGAGCTGACAAT	0.552000													4	137					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144747450	144747450	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:144747450T>C	ENST00000367545.3	+	6	433	c.433T>C	c.(433-435)Tcg>Ccg	p.S145P		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	145	Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGATGTCATGTCGGACCTGCA	0.478000													24	80					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174130844	174130844	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:174130844G>A	ENST00000375213.3	+	20	1847	c.1769G>A	c.(1768-1770)cGt>cAt	p.R590H	MLTK_ENST00000409176.2_Missense_Mutation_p.R590H|MLK7-AS1_ENST00000423106.2_RNA|MLK7-AS1_ENST00000422703.1_RNA	NM_016653.2	NP_057737.2												p.R590H(1)									TCTTTACAGCGTTCCCAGAGC	0.512000													6	19					0	0	1	0	0
TAS2R8	50836	broad.mit.edu	37	12	10958702	10958702	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:10958702C>A	ENST00000240615.2	-	1	1190	c.878G>T	c.(877-879)aGg>aTg	p.R293M		NM_023918.1	NP_076407.1	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	293					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						AAATGTCTGCCTCAGTTTATT	0.333000													21	36					1.96895e-08	2.03015e-08	1	1	0
SKOR1	390598	broad.mit.edu	37	15	68118741	68118741	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:68118741G>A	ENST00000380035.2	+	2	633	c.575G>A	c.(574-576)cGt>cAt	p.R192H	SKOR1_ENST00000554054.1_Missense_Mutation_p.R164H|SKOR1_ENST00000341418.5_Missense_Mutation_p.R378H|SKOR1_ENST00000554240.1_Missense_Mutation_p.R153H|SKOR1_ENST00000389002.1_Missense_Mutation_p.R183H			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	192					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						TGGGGCTCGCGTGGTAGCTTC	0.592000													36	104					0	0	1	0	0
SLC35B1	10237	broad.mit.edu	37	17	47780584	47780584	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:47780584A>G	ENST00000240333.6	-	7	849	c.728T>C	c.(727-729)aTc>aCc	p.I243T	SLC35B1_ENST00000415270.2_Missense_Mutation_p.I280T			P78383	S35B1_HUMAN	solute carrier family 35, member B1	243						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(1)	7						AAAGAGCAGGATGTTATAGAT	0.522000													9	116					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127760131	127760131	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:127760131G>A	ENST00000368679.4	-	12	1556	c.1247C>T	c.(1246-1248)cCg>cTg	p.P416L	ADAM12_ENST00000368676.4_Missense_Mutation_p.P416L	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	416	Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CCTGACTTCCGGCAGGTTAAA	0.542000													5	174					0	0	1	0	0
MANEAL	149175	broad.mit.edu	37	1	38265637	38265637	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:38265637T>C	ENST00000373045.6	+	4	1517	c.1136T>C	c.(1135-1137)gTc>gCc	p.V379A	RP11-109P14.9_ENST00000433474.1_RNA|MANEAL_ENST00000329006.5_Missense_Mutation_p.V157A|MANEAL_ENST00000525897.1_Missense_Mutation_p.V185A|MANEAL_ENST00000397631.3_3'UTR	NM_001113482.1	NP_001106954.1	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like	379						Golgi membrane|integral to membrane	hydrolase activity			endometrium(1)|large_intestine(1)|liver(1)|lung(1)|prostate(3)	7	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CGCAACAGGGTCAATGGCAAG	0.562000													20	98					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182852455	182852455	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:182852455T>C	ENST00000367549.3	+	25	3206	c.3096T>C	c.(3094-3096)agT>agC	p.S1032S	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	1032					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GTCCTTTTAGTAGCCAAGACA	0.358000													13	29					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155699	103155699	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:103155699G>A	ENST00000424685.2	-	50	8211	c.8052C>T	c.(8050-8052)cgC>cgT	p.R2684R	RELN_ENST00000343529.5_Silent_p.R2684R|RELN_ENST00000428762.1_Silent_p.R2684R			P78509	RELN_HUMAN	reelin	2684					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCAGGGGAGCGCTCATGCT	0.532000													17	49					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156618588	156618588	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156618588T>C	ENST00000329117.4	+	6	1334	c.998T>C	c.(997-999)tTc>tCc	p.F333S	BCAN_ENST00000361588.5_Missense_Mutation_p.F333S|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	333	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AAGACTCTCTTCCTCTTCCCC	0.607000													4	224					0	0	1	0	0
IL1RAP	3556	broad.mit.edu	37	3	190347252	190347252	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:190347252G>A	ENST00000412504.2	+	8	1268	c.1016G>A	c.(1015-1017)gGc>gAc	p.G339D	IL1RAP_ENST00000072516.3_Missense_Mutation_p.G339D|IL1RAP_ENST00000443369.2_Missense_Mutation_p.G339D|IL1RAP_ENST00000422485.1_Missense_Mutation_p.G339D|IL1RAP_ENST00000447382.1_Missense_Mutation_p.G339D|IL1RAP_ENST00000439062.1_Missense_Mutation_p.G339D|IL1RAP_ENST00000422940.1_Missense_Mutation_p.G339D|IL1RAP_ENST00000434491.1_Missense_Mutation_p.G198D|IL1RAP_ENST00000317757.3_Missense_Mutation_p.G339D			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	339	Ig-like C2-type 3.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		AGTGCCAAAGGCGAAGTTGCC	0.428000													9	44					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83520084	83520084	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:83520084A>G	ENST00000566620.1	+	7	1074	c.784A>G	c.(784-786)Acc>Gcc	p.T262A	CDH13_ENST00000569454.1_3'UTR|CDH13_ENST00000428848.3_Missense_Mutation_p.T223A|CDH13_ENST00000268613.10_Missense_Mutation_p.T309A	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	262	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CCCGGTAGGCACCACAGTGAT	0.567000													16	38					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93567810	93567810	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:93567810C>T	ENST00000394196.4	+	39	6430	c.5362C>T	c.(5362-5364)Cgc>Tgc	p.R1788C		NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1788					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTCAGATCCTCGCTCACCCCC	0.502000													4	74					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13699253	13699253	+	Missense_Mutation	SNP	G	G	A	rs139853925		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:13699253G>A	ENST00000357447.2	-	22	2704	c.2336C>T	c.(2335-2337)gCg>gTg	p.A779V	FRMD4A_ENST00000378503.1_Missense_Mutation_p.A779V|FRMD4A_ENST00000358621.4_Missense_Mutation_p.A764V	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	779						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						CCTCTGGCGCGCCTTGGACGG	0.731000													3	11					0	0	1	0	0
LETMD1	25875	broad.mit.edu	37	12	51449704	51449704	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:51449704G>A	ENST00000418425.2	+	5	618	c.599G>A	c.(598-600)cGg>cAg	p.R200Q	LETMD1_ENST00000380123.2_3'UTR|LETMD1_ENST00000262055.4_Missense_Mutation_p.R187Q|LETMD1_ENST00000550929.1_Missense_Mutation_p.R131Q|LETMD1_ENST00000548516.1_Intron|LETMD1_ENST00000552739.1_Missense_Mutation_p.R70Q|LETMD1_ENST00000547008.1_Intron	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	187	LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						CATGCTTTCCGGAAGCAGTCC	0.448000													4	148					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48608657	48608657	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:48608657G>A	ENST00000354276.3	-	3	380	c.53C>T	c.(52-54)gCg>gTg	p.A18V	PLA2G4C_ENST00000599921.1_Missense_Mutation_p.A18V|PLA2G4C_ENST00000413144.2_Missense_Mutation_p.A18V|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.A28V	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	18	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding	p.A18V(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CTCCACGGCCGCCTTTTCTTC	0.483000													6	152					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58145234	58145234	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58145234A>G	ENST00000544273.1	+	2	375	c.48A>G	c.(46-48)acA>acG	p.T16T	ZNF211_ENST00000254182.7_Intron|ZNF211_ENST00000420680.1_Intron|ZNF211_ENST00000240731.4_Intron|ZNF211_ENST00000391703.3_Intron|ZNF211_ENST00000541801.1_Intron|ZNF211_ENST00000299871.5_Intron|ZNF211_ENST00000347302.3_Intron			Q13398	ZN211_HUMAN	zinc finger protein 211	0						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ccaaggccacacaactggtga	0.522000													5	27					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8824861	8824861	+	Missense_Mutation	SNP	A	A	G	rs112747828		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:8824861A>G	ENST00000359865.3	+	15	3495	c.3353A>G	c.(3352-3354)tAc>tGc	p.Y1118C	SOGA2_ENST00000400050.3_Missense_Mutation_p.Y1077C|SOGA2_ENST00000518815.1_Missense_Mutation_p.Y443C|SOGA2_ENST00000306329.11_Missense_Mutation_p.Y1437C|SOGA2_ENST00000517570.1_Missense_Mutation_p.Y1077C|SOGA2_ENST00000306285.7_Missense_Mutation_p.Y443C	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1428																	AGCTGGGACTACACACCCAAC	0.642000													42	119					0	0	1	0	0
FAM175A	84142	broad.mit.edu	37	4	84390289	84390289	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:84390289T>C	ENST00000321945.7	-	6	600	c.492A>G	c.(490-492)gtA>gtG	p.V164V	FAM175A_ENST00000506553.1_Silent_p.V115V|MRPS18C_ENST00000509571.1_Intron|FAM175A_ENST00000505489.1_5'UTR	NM_139076.2	NP_620775.2	Q6UWZ7	F175A_HUMAN	family with sequence similarity 175, member A	164					chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	13						CCACTAAAGGTACCCTGTGAA	0.383000													35	99					0	0	1	0	0
TMEM25	84866	broad.mit.edu	37	11	118404221	118404221	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118404221A>G	ENST00000313236.5	+	5	813	c.760A>G	c.(760-762)Acc>Gcc	p.T254A	TMEM25_ENST00000411589.2_Intron|TMEM25_ENST00000524725.1_Intron|TMEM25_ENST00000442938.2_Intron|TMEM25_ENST00000354064.7_Intron|TMEM25_ENST00000354284.4_Missense_Mutation_p.T254A|TMEM25_ENST00000529001.1_3'UTR|TMEM25_ENST00000544878.1_Missense_Mutation_p.T157A|TMEM25_ENST00000533102.1_Missense_Mutation_p.T254A|TMEM25_ENST00000359862.4_Intron	NM_032780.3	NP_116169.2	Q86YD3	TMM25_HUMAN	transmembrane protein 25	254						extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|stomach(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		GGGGTTCAGCACCTTGGTGGC	0.607000													24	62					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265497	3265497	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:3265497G>A	ENST00000520002.1	-	15	2553	c.1998C>T	c.(1996-1998)agC>agT	p.S666S	CSMD1_ENST00000602557.1_Silent_p.S666S|CSMD1_ENST00000602723.1_Silent_p.S666S|CSMD1_ENST00000539096.1_Silent_p.S665S|CSMD1_ENST00000542608.1_Silent_p.S665S|CSMD1_ENST00000537824.1_Silent_p.S665S|CSMD1_ENST00000400186.3_Silent_p.S666S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	666	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATGCCCACTGCTGGCCAGCT	0.488000													20	33					0	0	1	0	0
CNTLN	54875	broad.mit.edu	37	9	17340896	17340896	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:17340896C>T	ENST00000380647.3	+	11	1800	c.1716C>T	c.(1714-1716)aaC>aaT	p.N572N	CNTLN_ENST00000425824.1_Silent_p.N572N|CNTLN_ENST00000262360.5_Silent_p.N572N			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	572						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		TACAGACCAACTACAGAGCAG	0.388000													7	42					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73461507	73461507	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:73461507A>G	ENST00000377110.2	-	4	706	c.462_splice	c.e4-1	p.Y155_splice	TRPM3_ENST00000357533.2_Splice_Site_p.Y157_splice|TRPM3_ENST00000396292.4_Splice_Site_p.Y2_splice|TRPM3_ENST00000396285.1_Splice_Site_p.Y2_splice|TRPM3_ENST00000396283.1_Splice_Site_p.Y2_splice|TRPM3_ENST00000377097.3_Splice_Site_p.Y2_splice|TRPM3_ENST00000396280.5_Splice_Site_p.Y2_splice|TRPM3_ENST00000360823.2_Splice_Site_p.Y2_splice|TRPM3_ENST00000408909.2_Splice_Site_p.Y2_splice|TRPM3_ENST00000377101.1_Splice_Site_p.Y2_splice|TRPM3_ENST00000423814.3_Splice_Site_p.Y157_splice|TRPM3_ENST00000377111.2_Splice_Site_p.Y155_splice|TRPM3_ENST00000377106.1_Splice_Site_p.Y2_splice|TRPM3_ENST00000358082.3_Splice_Site_p.Y2_splice|TRPM3_ENST00000361823.5_Splice_Site_p.Y2_splice|TRPM3_ENST00000377105.1_Splice_Site_p.Y2_splice	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	155						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						ACTCGCACATACTGGAAGAAG	0.428000													15	52					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31255934	31255934	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:31255934G>A	ENST00000407793.2	+	24	2688	c.2437G>A	c.(2437-2439)Gcc>Acc	p.A813T	DDX11_ENST00000542838.1_Missense_Mutation_p.A813T|DDX11_ENST00000350437.4_Missense_Mutation_p.A763T|DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000228264.6_Missense_Mutation_p.A787T|DDX11_ENST00000545668.1_Missense_Mutation_p.A813T	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	813					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GGAGAAGATGGCCTACTTGGA	0.607000										Multiple Myeloma(12;0.14)			14	68					0	0	1	0	0
LINS	55180	broad.mit.edu	37	15	101120735	101120735	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:101120735A>G	ENST00000314742.8	-	2	535	c.313T>C	c.(313-315)Tct>Cct	p.S105P	LINS_ENST00000560133.1_Intron|LINS_ENST00000559149.1_5'UTR|LINS_ENST00000561308.1_Missense_Mutation_p.S105P	NM_001040616.2	NP_001035706.1	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	105										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						GTTTTGACAGACAATATCCGG	0.403000													19	53					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95590838	95590838	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:95590838T>C	ENST00000526495.1	-	10	1362	c.1071A>G	c.(1069-1071)gcA>gcG	p.A357A	DICER1_ENST00000343455.3_Silent_p.A357A|DICER1_ENST00000541352.1_Silent_p.A357A|DICER1_ENST00000393063.1_Silent_p.A357A|DICER1_ENST00000527414.1_Silent_p.A357A			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	357	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CTTCACATAGTGCATGTATTT	0.368000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				29	103					0	0	1	0	0
PNKD	25953	broad.mit.edu	37	2	219204794	219204794	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:219204794G>A	ENST00000273077.4	+	4	446	c.395G>A	c.(394-396)aGc>aAc	p.S132N	PNKD_ENST00000258362.3_Missense_Mutation_p.S108N|AC021016.8_ENST00000411433.1_RNA|PNKD_ENST00000436005.2_Missense_Mutation_p.S72N	NM_015488.4	NP_056303.3	Q8N490	PNKD_HUMAN	paroxysmal nonkinesigenic dyskinesia	132						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACAACTACAGCTACCTCATC	0.662000													19	83					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10429085	10429085	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10429085C>T	ENST00000245503.5	-	31	4680	c.4296G>A	c.(4294-4296)gaG>gaA	p.E1432E	MYH2_ENST00000397183.2_Silent_p.E1432E|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1432					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCATGAGGTCCTCGACCTCAT	0.537000													29	107					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	429622	429622	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:429622T>C	ENST00000332826.6	-	11	947	c.863A>G	c.(862-864)cAg>cGg	p.Q288R		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	288						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						GCGGGCGCGCTGCCGCTTCCA	0.687000													16	68					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52400777	52400777	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52400777C>T	ENST00000420323.2	+	36	5900	c.5639C>T	c.(5638-5640)aCg>aTg	p.T1880M		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1880	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCTGCCATGACGTCACTGAAA	0.612000													29	87					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077629	19077629	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:19077629A>G	ENST00000329773.2	-	2	408	c.321T>C	c.(319-321)acT>acC	p.T107T		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	107					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						AGGTCATCACAGTGGTGAAGA	0.547000													19	110					0	0	1	0	0
AS3MT	57412	broad.mit.edu	37	10	104660390	104660390	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:104660390A>T	ENST00000369880.3	+	11	1138	c.1061A>T	c.(1060-1062)gAc>gTc	p.D354V	C10ORF32_ENST00000299353.6_3'UTR	NM_020682.3	NP_065733.2	Q9HBK9	AS3MT_HUMAN	arsenic (+3 oxidation state) methyltransferase	354					arsonoacetate metabolic process|toxin metabolic process	cytosol	arsenite methyltransferase activity|methylarsonite methyltransferase activity			large_intestine(1)|lung(6)	7		Colorectal(252;0.122)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;5.87e-09)|all cancers(201;1.58e-07)|BRCA - Breast invasive adenocarcinoma(275;0.223)		GAAGAGTCTGACAGTATGAAG	0.443000													27	96					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149492408	149492408	+	RNA	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:149492408C>A	ENST00000378016.2	+	0	6297							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCTCCCACCCAGGGGCCCA	0.672000													14	37					1.49906e-05	1.53131e-05	1	1	0
SGSM1	129049	broad.mit.edu	37	22	25308672	25308672	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:25308672G>A	ENST00000400358.4	+	22	2938	c.2881G>A	c.(2881-2883)Gga>Aga	p.G961R	SGSM1_ENST00000400359.4_Missense_Mutation_p.G1016R	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1016	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						CTTCCCCCACGGAGGCGCCAT	0.512000													5	21					0	0	1	0	0
ZNF749	388567	broad.mit.edu	37	19	57955220	57955220	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:57955220A>G	ENST00000334181.4	+	3	954	c.704A>G	c.(703-705)tAc>tGc	p.Y235C	AC004076.9_ENST00000596831.1_Intron	NM_001023561.2	NP_001018855.2	O43361	ZN749_HUMAN	zinc finger protein 749	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|lung(3)|prostate(1)	13		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TTGTTTAGGTACAACTCCAAC	0.418000													17	67					0	0	1	0	0
PIAS4	51588	broad.mit.edu	37	19	4033130	4033130	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:4033130G>A	ENST00000262971.2	+	8	1055	c.940G>A	c.(940-942)Gag>Aag	p.E314K		NM_015897.2	NP_056981.2	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	314					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(3)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTGACAGCGAGATCGCCAC	0.682000													29	96					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828508	18828508	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:18828508A>T	ENST00000396576.2	+	13	2174	c.1673A>T	c.(1672-1674)gAt>gTt	p.D558V	CACNB2_ENST00000377331.2_Missense_Mutation_p.D561V|CACNB2_ENST00000377329.4_Missense_Mutation_p.D559V|CACNB2_ENST00000377319.3_Missense_Mutation_p.D520V|CACNB2_ENST00000282343.8_Missense_Mutation_p.D585V|CACNB2_ENST00000377328.1_Missense_Mutation_p.D363V|CACNB2_ENST00000377315.4_Missense_Mutation_p.D565V|RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000324631.7_Missense_Mutation_p.D613V|CACNB2_ENST00000352115.6_Missense_Mutation_p.D589V	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	613					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CGGGACGTGGATCGAGAGCAG	0.557000													20	85					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32266051	32266051	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:32266051A>G	ENST00000343380.5	-	4	820	c.681T>C	c.(679-681)tgT>tgC	p.C227C		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	227	Dimerization (Potential).|Required for interaction with TRIM28.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						GCTGCGTAGTACAGATATTCA	0.622000													20	36					0	0	1	0	0
BLOC1S1	2647	broad.mit.edu	37	12	56112959	56112959	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56112959G>C	ENST00000550412.1	+	3	319	c.303G>C	c.(301-303)caG>caC	p.Q101H	RP11-644F5.10_ENST00000549424.1_Missense_Mutation_p.Q23H|BLOC1S1_ENST00000548556.1_Missense_Mutation_p.Q23H|BLOC1S1_ENST00000548925.1_Missense_Mutation_p.Q101H|BLOC1S1_ENST00000547076.1_Missense_Mutation_p.Q23H|BLOC1S1_ENST00000551926.1_Missense_Mutation_p.Q23H|BLOC1S1_ENST00000549147.1_Missense_Mutation_p.Q101H|BLOC1S1_ENST00000257899.2_Missense_Mutation_p.Q73H																endometrium(1)|lung(1)	2						TTGCCAAGCAGACAGGCCAGT	0.592000													25	77					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52430695	52430695	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52430695G>A	ENST00000420323.2	+	72	11753	c.11492G>A	c.(11491-11493)cGc>cAc	p.R3831H		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3896	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCCCTGGAGCGCCATAAGTTT	0.577000													5	159					0	0	1	0	0
MEMO1	51072	broad.mit.edu	37	2	32108519	32108519	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:32108519C>T	ENST00000295065.4	-	7	902	c.593G>A	c.(592-594)cGt>cAt	p.R198H	MEMO1_ENST00000426310.2_Missense_Mutation_p.R175H|DPY30_ENST00000446765.1_5'UTR|MEMO1_ENST00000490459.1_Intron|MEMO1_ENST00000404530.1_Missense_Mutation_p.R198H|MEMO1_ENST00000379383.3_Missense_Mutation_p.R201H	NM_015955.2	NP_057039.1	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1	198					regulation of microtubule-based process	cytosol|nucleus				NS(1)|breast(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	17	Acute lymphoblastic leukemia(172;0.155)					GTAACTGTAACGGAACCTTTG	0.338000													63	209					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8701401	8701401	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:8701401A>G	ENST00000329805.4	-	1	1266	c.1038T>C	c.(1036-1038)tgT>tgC	p.C346C		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	346						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						CCCACTGCTGACAGATGGGAA	0.577000													18	61					0	0	1	0	0
ETFA	2108	broad.mit.edu	37	15	76580213	76580213	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:76580213T>G	ENST00000557943.1	-	5	505	c.425A>C	c.(424-426)gAc>gCc	p.D142A	ETFA_ENST00000560726.1_5'UTR|ETFA_ENST00000433983.2_Missense_Mutation_p.D93A|ETFA_ENST00000559602.1_Missense_Mutation_p.D38A	NM_000126.3	NP_000117.1	P13804	ETFA_HUMAN	electron-transfer-flavoprotein, alpha polypeptide	142					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9						CACAAATGTGTCAGGTGACTT	0.353000													20	44					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41122815	41122815	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41122815T>A	ENST00000308370.7	+	23	3034	c.3034T>A	c.(3034-3036)Tat>Aat	p.Y1012N	LTBP4_ENST00000396819.3_Missense_Mutation_p.Y945N|LTBP4_ENST00000204005.9_Missense_Mutation_p.Y975N|LTBP4_ENST00000243562.9_Intron|LTBP4_ENST00000545697.1_Intron|LTBP4_ENST00000602240.1_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1012	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTGCCAAGAATATGGTCCCGA	0.567000													18	36					0	0	1	0	0
NXPH3	11248	broad.mit.edu	37	17	47656067	47656067	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:47656067C>A	ENST00000328741.5	+	2	526	c.164C>A	c.(163-165)cCt>cAt	p.P55H	NXPH3_ENST00000513748.1_Missense_Mutation_p.P55H	NM_007225.2	NP_009156.2	O95157	NXPH3_HUMAN	neurexophilin 3	55	II.				neuropeptide signaling pathway	extracellular region				endometrium(2)|large_intestine(3)|lung(4)|pancreas(1)|skin(2)	12	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CACATCTCACCTAAGTCCCGC	0.697000													31	66					8.16721e-17	8.58394e-17	1	1	0
FAM47B	170062	broad.mit.edu	37	X	34962126	34962126	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:34962126G>A	ENST00000329357.5	+	1	1214	c.1178G>A	c.(1177-1179)cGg>cAg	p.R393Q		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	393								p.R393Q(1)		breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TTTGAGAGTCGGATGCCCCAT	0.587000													19	29					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74695112	74695112	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:74695112T>C	ENST00000361070.4	-	2	333	c.236A>G	c.(235-237)gAc>gGc	p.D79G	RFWD3_ENST00000571750.1_Missense_Mutation_p.D79G	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	79					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						TTCTGTCAGGTCAACAGACAG	0.547000													35	110					0	0	1	0	0
IGLV5-52	28779	broad.mit.edu	37	22	22673463	22673463	+	RNA	SNP	C	C	T	rs150977964	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:22673463C>T	ENST00000390289.2	+	0	261				LL22NC03-80A10.6_ENST00000426066.1_RNA																							AGTTCCCAGCCGCTTCTCTGG	0.542000													47	154					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228495962	228495962	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:228495962A>G	ENST00000570156.2	+	58	15562	c.15488A>G	c.(15487-15489)gAg>gGg	p.E5163G	OBSCN_ENST00000366707.4_Missense_Mutation_p.E1840G|OBSCN_ENST00000284548.11_Missense_Mutation_p.E4206G|OBSCN_ENST00000422127.1_Missense_Mutation_p.E4206G|OBSCN_ENST00000366709.4_Missense_Mutation_p.E1325G	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4206	Ig-like 49.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAGGTGACAGAGGTGGCTGTG	0.617000													3	52					0	0	1	0	0
FBXL8	55336	broad.mit.edu	37	16	67195837	67195837	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67195837T>A	ENST00000258200.3	+	2	326	c.149T>A	c.(148-150)aTc>aAc	p.I50N	FBXL8_ENST00000521920.1_Missense_Mutation_p.I50N|FBXL8_ENST00000518148.1_Missense_Mutation_p.I50N|FBXL8_ENST00000519917.1_Missense_Mutation_p.I50N			Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	50							protein binding			endometrium(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		GACACAAAAATCAGGTGAGCC	0.632000													5	15					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29301191	29301191	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:29301191T>C	ENST00000378993.1	+	3	892	c.219T>C	c.(217-219)agT>agC	p.S73S	IL1RAPL1_ENST00000302196.4_Silent_p.S73S	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	73	Ig-like C2-type 1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						CTGGACTCAGTTTGATGTGGT	0.428000													18	35					0	0	1	0	0
TERF2IP	54386	broad.mit.edu	37	16	75681828	75681828	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:75681828T>C	ENST00000300086.4	+	1	145	c.48T>C	c.(46-48)caT>caC	p.H16H		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	16					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						GGCCCACCCATTCCTCGACTC	0.652000													18	57					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43606836	43606836	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:43606836A>G	ENST00000355710.3	+	7	1677	c.1445A>G	c.(1444-1446)cAc>cGc	p.H482R	RET_ENST00000340058.5_Missense_Mutation_p.H482R	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	482					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GCCGAACTTCACTACATGGTG	0.632000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				4	76					0	0	1	0	0
HYOU1	10525	broad.mit.edu	37	11	118916308	118916308	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118916308T>C	ENST00000404233.3	-	26	3121	c.2997A>G	c.(2995-2997)ctA>ctG	p.L999L	HYOU1_ENST00000529972.1_Silent_p.L937L|HYOU1_ENST00000525859.1_Silent_p.L937L	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	999						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GTGGGGGTTATAGTTCGTCGT	0.522000													7	182					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105201725	105201725	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:105201725A>G	ENST00000369797.3	+	31	4794	c.4700A>G	c.(4699-4701)cAa>cGa	p.Q1567R		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1567					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AAGCCACACCAAGCCACGGTG	0.557000													12	57					0	0	1	0	0
ZIC2	7546	broad.mit.edu	37	13	100635069	100635069	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:100635069T>C	ENST00000376335.3	+	1	1044	c.751T>C	c.(751-753)Tgc>Cgc	p.C251R		NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	251	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCGGCAGCAGTGCATCAAGCA	0.557000													5	154					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170058296	170058296	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:170058296T>C	ENST00000263816.3	-	44	8579	c.8294A>G	c.(8293-8295)gAc>gGc	p.D2765G		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2765	LDL-receptor class A 17.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCACCACAGTCATTGTAGTA	0.498000													26	60					0	0	1	0	0
CCZ1B	221960	broad.mit.edu	37	7	6864105	6864105	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:6864105T>C	ENST00000316731.8	-	3	865	c.293A>G	c.(292-294)gAa>gGa	p.E98G	CCZ1B_ENST00000538180.1_Intron	NM_198097.3	NP_932765.1	P86790	CCZ1L_HUMAN	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	98						lysosomal membrane											CCAGAAATTTTCTTCTGGTTC	0.338000													28	90					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97185296	97185296	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:97185296C>T	ENST00000514100.1	+	4	282	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F	EPHA6_ENST00000389672.5_Intron|EPHA6_ENST00000502694.1_Missense_Mutation_p.L14F|EPHA6_ENST00000442602.2_Intron	NM_001278300.1	NP_001265229.1	Q9UF33	EPHA6_HUMAN	EPH receptor A6	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						actgtactggcttaatgaaaa	0.433000													11	54					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27528642	27528642	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27528642C>T	ENST00000296098.4	+	6	1196	c.926C>T	c.(925-927)gCc>gTc	p.A309V	TRIM54_ENST00000380075.2_Missense_Mutation_p.A267V	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	267	COS.				cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGGAGTCTGCCATCCAGTCC	0.642000													7	13					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53574192	53574192	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:53574192T>A	ENST00000025008.5	-	9	1784	c.1261A>T	c.(1261-1263)Atg>Ttg	p.M421L	RB1CC1_ENST00000539297.1_Missense_Mutation_p.M421L|RB1CC1_ENST00000435644.2_Missense_Mutation_p.M421L|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	421					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AACATAATCATCAACTGATTT	0.348000													5	138					0	0	1	0	0
IGF2	3481	broad.mit.edu	37	11	2154836	2154836	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:2154836G>A	ENST00000416167.2	-	3	1383	c.217C>T	c.(217-219)Cgc>Tgc	p.R73C	IGF2_ENST00000418738.2_Missense_Mutation_p.R73C|IGF2_ENST00000434045.2_Missense_Mutation_p.R129C|IGF2_ENST00000381406.4_Missense_Mutation_p.R76C|IGF2_ENST00000337883.6_Missense_Mutation_p.R73C|IGF2_ENST00000381392.1_Missense_Mutation_p.R76C|IGF2_ENST00000381395.1_Missense_Mutation_p.R73C|IGF2_ENST00000300632.5_Missense_Mutation_p.R73C|IGF2_ENST00000381389.1_Missense_Mutation_p.R73C			P01344	IGF2_HUMAN	insulin-like growth factor 2 (somatomedin A)	73	A.				glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)|kidney(1)|lung(1)|pancreas(1)|skin(1)|urinary_tract(1)	6		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		TCACAGCTGCGGAAACAGCAC	0.657000													17	33					0	0	1	0	0
SNRNP27	11017	broad.mit.edu	37	2	70123669	70123669	+	Missense_Mutation	SNP	G	G	A	rs139699067		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:70123669G>A	ENST00000244227.3	+	3	682	c.257G>A	c.(256-258)cGg>cAg	p.R86Q	SNRNP27_ENST00000409116.1_Missense_Mutation_p.R86Q|SNRNP27_ENST00000488986.1_3'UTR	NM_006857.2	NP_006848.1	Q8WVK2	SNR27_HUMAN	small nuclear ribonucleoprotein 27kDa (U4/U6.U5)	86					mRNA processing|RNA splicing	nucleus	nucleic acid binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	11						aGCAAAGAACGGCAGATTACT	0.328000													4	41					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42492485	42492485	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42492485G>T	ENST00000545399.1	-	3	330	c.177C>A	c.(175-177)aaC>aaA	p.N59K	ATP1A3_ENST00000302102.5_Missense_Mutation_p.N46K|ATP1A3_ENST00000543770.1_Missense_Mutation_p.N57K|ATP1A3_ENST00000468774.2_5'UTR|ATP1A3_ENST00000602133.1_Missense_Mutation_p.N16K	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	46					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CACAGTCTGTGTTGTATTTCC	0.617000													5	294					4.096e-09	4.23106e-09	1	1	0
HERC2	8924	broad.mit.edu	37	15	28502276	28502276	+	Silent	SNP	G	G	A	rs12903263	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:28502276G>A	ENST00000261609.7	-	17	2556	c.2448C>T	c.(2446-2448)tcC>tcT	p.S816S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	816					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCCAGTCCGCGGAACCATCCA	0.552000													33	92					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2377243	2377243	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:2377243A>G	ENST00000202625.2	+	4	577	c.516A>G	c.(514-516)atA>atG	p.I172M	TGM6_ENST00000477505.1_Intron|TGM6_ENST00000381423.1_Missense_Mutation_p.I172M	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	172					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	AGAAGCACATACGAGCCCAGG	0.617000													17	36					0	0	1	0	0
OSBPL11	114885	broad.mit.edu	37	3	125271230	125271230	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:125271230A>T	ENST00000296220.5	-	9	1738	c.1449T>A	c.(1447-1449)aaT>aaA	p.N483K		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	483					lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						AAGGAGCATGATTTGTGACTC	0.468000													28	39					0	0	1	0	0
B3GNT7	93010	broad.mit.edu	37	2	232262574	232262574	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:232262574C>A	ENST00000287590.5	+	2	405	c.144C>A	c.(142-144)gcC>gcA	p.A48A	B3GNT7_ENST00000479618.1_3'UTR	NM_145236.2	NP_660279.1	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	48					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)	17		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		CACAGAAGGCCCAGAAGCCAA	0.642000													19	56					3.32936e-07	3.41723e-07	1	1	0
IFI35	3430	broad.mit.edu	37	17	41166213	41166213	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:41166213T>C	ENST00000415816.2	+	7	981	c.758T>C	c.(757-759)aTc>aCc	p.I253T	IFI35_ENST00000438323.2_Missense_Mutation_p.I255T	NM_005533.4	NP_005524.2	P80217	IN35_HUMAN	interferon-induced protein 35	253					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		GTCCTGGAGATCCACTTCCAG	0.612000													31	89					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47635470	47635470	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:47635470C>G	ENST00000371917.4	+	34	4559	c.4559C>G	c.(4558-4560)tCt>tGt	p.S1520C		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1520					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AAAAATCCCTCTGAGAGGGGA	0.413000													14	37					0	0	1	0	0
RSL24D1	51187	broad.mit.edu	37	15	55484953	55484953	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:55484953C>T	ENST00000260443.4	-	2	336	c.160G>A	c.(160-162)Gca>Aca	p.A54T	RSL24D1_ENST00000565854.1_5'UTR	NM_016304.2	NP_057388.1	Q9UHA3	RLP24_HUMAN	ribosomal L24 domain containing 1	54					ribosome biogenesis|translation	nucleolus|ribosome	structural constituent of ribosome			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	7						TTCCGGAATGCTTTGGTCCAC	0.348000													23	75					0	0	1	0	0
RGS20	8601	broad.mit.edu	37	8	54866827	54866827	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:54866827G>T	ENST00000297313.3	+	5	1027	c.935G>T	c.(934-936)aGg>aTg	p.R312M	RGS20_ENST00000517405.1_3'UTR|RGS20_ENST00000522225.1_Missense_Mutation_p.R46M|RGS20_ENST00000276500.4_Missense_Mutation_p.R165M|RGS20_ENST00000344277.6_Missense_Mutation_p.R197M	NM_170587.2	NP_733466.1	O76081	RGS20_HUMAN	regulator of G-protein signaling 20	312	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			breast(2)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			GAGAAAGCAAGGATAATCTAT	0.388000													17	87					5.01169e-05	5.10218e-05	1	1	0
SLITRK5	26050	broad.mit.edu	37	13	88329395	88329395	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:88329395C>T	ENST00000325089.6	+	2	1971	c.1752C>T	c.(1750-1752)ggC>ggT	p.G584G	SLITRK5_ENST00000400028.3_Silent_p.G343G	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	584	LRRCT 2.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TCAAAGTGGGCGTCCTAGTGG	0.522000													64	218					0	0	1	0	0
NME4	4833	broad.mit.edu	37	16	450236	450236	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:450236G>A	ENST00000397722.1	+	5	722	c.248G>A	c.(247-249)aGc>aAc	p.S83N	NME4_ENST00000382940.4_Missense_Mutation_p.S161N|NME4_ENST00000219479.2_Missense_Mutation_p.S153N|NME4_ENST00000450036.1_Missense_Mutation_p.S83N			O00746	NDKM_HUMAN	NME/NM23 nucleoside diphosphate kinase 4	153					CTP biosynthetic process|GTP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|UTP biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			NS(1)|lung(1)|stomach(1)|urinary_tract(1)	4		Hepatocellular(16;0.00015)				ATCCACGCCAGCGACTCCGTG	0.637000													37	104					0	0	1	0	0
CD99	4267	broad.mit.edu	37	X	2644347	2644347	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:2644347C>T	ENST00000381192.3	+	8	590	c.408C>T	c.(406-408)gtC>gtT	p.V136V	CD99_ENST00000482405.2_3'UTR|CD99_ENST00000381184.1_Silent_p.V136V|CD99_ENST00000381187.3_Silent_p.V120V	NM_001277710.1|NM_002414.3	NP_001264639.1|NP_002405.1	P14209	CD99_HUMAN	CD99 molecule	136					cell adhesion	cytoplasm|integral to plasma membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11						CTGTCGTGGTCGCCGTGGCTG	0.562000													4	78					0	0	1	0	0
MROH6	642475	broad.mit.edu	37	8	144654310	144654310	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144654310A>G	ENST00000398882.3	-	2	596	c.340T>C	c.(340-342)Ttg>Ctg	p.L114L		NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		GCCGTGTACAACGCGAGGTCG	0.657000													4	113					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508556	106508556	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:106508556C>T	ENST00000359195.3	+	2	860	c.550C>T	c.(550-552)Cgc>Tgc	p.R184C	PIK3CG_ENST00000496166.1_Missense_Mutation_p.R184C|PIK3CG_ENST00000440650.2_Missense_Mutation_p.R184C	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	184					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GGTGACCCCGCGCATGGCGGA	0.647000													16	83					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45833830	45833830	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45833830A>G	ENST00000397928.1	+	20	3464	c.3019A>G	c.(3019-3021)Aag>Gag	p.K1007E	TRPM2_ENST00000300481.9_Missense_Mutation_p.K987E|TRPM2_ENST00000300482.5_Missense_Mutation_p.K1007E|TRPM2_ENST00000397932.2_Missense_Mutation_p.K1007E|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1007						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CTACAAGCCTAAGTGCCCCGA	0.612000													5	433					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45260945	45260945	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:45260945A>G	ENST00000164227.5	+	6	1100	c.856A>G	c.(856-858)Aac>Gac	p.N286D		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	286					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CGCCGTGGAAAACAACAGCCT	0.652000			T	IGH@	CLL								11	125					0	0	1	0	0
SGSM3	27352	broad.mit.edu	37	22	40804998	40804998	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:40804998G>A	ENST00000248929.9	+	19	2153	c.1964G>A	c.(1963-1965)cGc>cAc	p.R655H	SGSM3_ENST00000454798.2_Missense_Mutation_p.R588H	NM_015705.4	NP_056520.2	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	655	RUN.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)	19						GTGAAGCTCCGCTCACTGATC	0.612000													4	6					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50346906	50346906	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:50346906T>C	ENST00000394697.2	+	22	3050	c.2710T>C	c.(2710-2712)Tgc>Cgc	p.C904R	ADCY7_ENST00000254235.3_Missense_Mutation_p.C904R			P51828	ADCY7_HUMAN	adenylate cyclase 7	904	Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	AGGGCTGGAGTGCCTACGCCT	0.567000													12	61					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23745593	23745593	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23745593T>C	ENST00000357460.5	-	2	1008	c.844A>G	c.(844-846)Act>Gct	p.T282A	HOMEZ_ENST00000431326.2_Missense_Mutation_p.T284A|HOMEZ_ENST00000561013.1_Missense_Mutation_p.T284A	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	282						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GAAGAGGGAGTAACACTAGAT	0.527000													22	39					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52417474	52417474	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52417474G>A	ENST00000420323.2	+	51	8275	c.8014G>A	c.(8014-8016)Gcg>Acg	p.A2672T		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2672	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTGTATACTGCGGACGAGCA	0.557000													14	41					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25718726	25718726	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25718726C>T	ENST00000520164.1	-	13	1718	c.1181G>A	c.(1180-1182)cGa>cAa	p.R394Q	EBF2_ENST00000408929.3_Missense_Mutation_p.R246Q|EBF2_ENST00000535548.1_Missense_Mutation_p.R125Q	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	394					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GTCTGCGGCTCGCTTCAAAAT	0.488000													65	100					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112189315	112189315	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:112189315T>C	ENST00000412145.1	-	7	3076	c.523A>G	c.(523-525)Acg>Gcg	p.T175A	PTPN3_ENST00000374541.2_Missense_Mutation_p.T306A|PTPN3_ENST00000446349.1_Missense_Mutation_p.T175A|PTPN3_ENST00000262539.3_Missense_Mutation_p.T197A	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	306	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TGAAAGAACGTATGGTGCTCA	0.443000													33	76					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31437751	31437751	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:31437751T>C	ENST00000373747.3	-	14	2195	c.2096A>G	c.(2095-2097)aAc>aGc	p.N699S	PUM1_ENST00000440538.2_Missense_Mutation_p.N672S|PUM1_ENST00000257075.5_Missense_Mutation_p.N698S|PUM1_ENST00000426105.2_Missense_Mutation_p.N698S|PUM1_ENST00000424085.2_Missense_Mutation_p.N456S|PUM1_ENST00000423018.2_Missense_Mutation_p.N554S|PUM1_ENST00000373741.4_Missense_Mutation_p.N734S|PUM1_ENST00000373742.2_Missense_Mutation_p.N639S	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	698	Ser-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AGTGTTGGAGTTTGCAACTAA	0.483000													14	63					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95486519	95486519	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:95486519A>G	ENST00000343958.4	-	16	3926	c.3703T>C	c.(3703-3705)Ttc>Ctc	p.F1235L	FGD6_ENST00000546711.1_Missense_Mutation_p.F1235L	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1235					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						GTGAGAGTGAATTCGCTTGTG	0.488000													12	50					0	0	1	0	0
SYVN1	84447	broad.mit.edu	37	11	64897199	64897199	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:64897199A>G	ENST00000526060.1	-	14	1785		c.e14+1		SYVN1_ENST00000307289.6_Splice_Site|SYVN1_ENST00000377190.3_Splice_Site|SYVN1_ENST00000294256.8_Splice_Site			Q86TM6	SYVN1_HUMAN	synovial apoptosis inhibitor 1, synoviolin						ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						GTACAGACACACCCCAAGGAG	0.607000													18	63					0	0	1	0	0
ZNF442	79973	broad.mit.edu	37	19	12460905	12460905	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:12460905A>G	ENST00000242804.4	-	6	2076	c.1494T>C	c.(1492-1494)agT>agC	p.S498S	ZNF442_ENST00000438182.1_Silent_p.S429S	NM_030824.2	NP_110451.1	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	31						ATGTGAAACAACTGAATGCTT	0.363000													9	102					0	0	1	0	0
CCRL2	9034	broad.mit.edu	37	3	46449604	46449604	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:46449604T>A	ENST00000399036.3	+	2	386	c.34T>A	c.(34-36)Tat>Aat	p.Y12N	ACKR5_ENST00000400882.2_Missense_Mutation_p.Y12N|ACKR5_ENST00000400880.3_Missense_Mutation_p.Y12N|ACKR5_ENST00000357392.4_Missense_Mutation_p.Y24N	NM_003965.4	NP_003956.2																					AGAGGATGAATATGATGTCCT	0.532000													4	11					0	0	1	0	0
VGLL1	51442	broad.mit.edu	37	X	135618205	135618205	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:135618205T>A	ENST00000370634.3	+	2	196	c.26T>A	c.(25-27)aTc>aAc	p.I9N		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					AAGACTGCCATCCGGCTGCCC	0.488000													7	63					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80546021	80546021	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:80546021T>C	ENST00000265361.3	-	2	638	c.77A>G	c.(76-78)cAa>cGa	p.Q26R	SEMA3C_ENST00000419255.2_Missense_Mutation_p.Q26R|SEMA3C_ENST00000487621.1_5'UTR|SEMA3C_ENST00000544525.1_Missense_Mutation_p.Q44R|SEMA3C_ENST00000536800.1_5'UTR	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	26					immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AACTCTTGCTTGGGGCTGGGA	0.343000													27	61					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338636	13338636	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:13338636A>G	ENST00000602906.1	+	0	448																				kidney(3)|lung(1)	4						TGGTAGGGGTACCAAAGTGAT	0.478000													23	68					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72209691	72209691	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:72209691A>G	ENST00000438125.1	-	0	577							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GAATACTCCTACTAGTATCTG	0.368000													6	5					0	0	1	0	0
UTP6	55813	broad.mit.edu	37	17	30213066	30213066	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:30213066A>G	ENST00000261708.4	-	9	773	c.636T>C	c.(634-636)taT>taC	p.Y212Y	CTC-542B22.2_ENST00000583236.1_lincRNA|UTP6_ENST00000490218.2_5'UTR	NM_018428.2	NP_060898.2	Q9NYH9	UTP6_HUMAN	UTP6, small subunit (SSU) processome component, homolog (yeast)	212					rRNA processing	nucleolus	binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)	21		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				TTTCTTCAGAATAATCAGGAT	0.348000													20	55					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187540341	187540341	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:187540341T>C	ENST00000261023.3	+	27	2991	c.2717T>C	c.(2716-2718)gTt>gCt	p.V906A	ITGAV_ENST00000374907.3_Missense_Mutation_p.V870A|ITGAV_ENST00000433736.2_Missense_Mutation_p.V860A|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	906					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GGTTGTGGAGTTGCTCAGTGC	0.368000													27	92					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19744652	19744652	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19744652T>C	ENST00000203556.4	-	19	2569	c.2432A>G	c.(2431-2433)cAc>cGc	p.H811R	GMIP_ENST00000445806.2_Missense_Mutation_p.H782R|GMIP_ENST00000587238.1_Missense_Mutation_p.H785R	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	811	Pro-rich.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAGGGTACTGtggtgctgggg	0.637000													12	28					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47881256	47881256	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:47881256C>G	ENST00000396105.1	-	5	2394	c.2148G>C	c.(2146-2148)atG>atC	p.M716I	ZNFX1_ENST00000371754.4_Missense_Mutation_p.M716I|ZNFX1_ENST00000371752.1_Missense_Mutation_p.M716I	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	716							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GACTTACACTCATGTAGGCCC	0.537000													58	171					0	0	1	0	0
USP42	84132	broad.mit.edu	37	7	6182587	6182587	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:6182587T>C	ENST00000306177.5	+	8	978	c.820T>C	c.(820-822)Ttg>Ctg	p.L274L		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	274					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		CAACAAGGCATTGGAGCAGTT	0.532000													23	68					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23292926	23292926	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:23292926T>C	ENST00000358689.4	-	11	1674	c.1439A>G	c.(1438-1440)cAt>cGt	p.H480R	ENTPD4_ENST00000521321.1_5'UTR|ENTPD4_ENST00000356206.6_Missense_Mutation_p.H472R|ENTPD4_ENST00000417069.2_Missense_Mutation_p.H472R	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	480					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		GAGGTCAGCATGAGAGGCGTA	0.473000													4	70					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125047642	125047642	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:125047642T>C	ENST00000522917.1	+	19	2617	c.2411T>C	c.(2410-2412)aTg>aCg	p.M804T	FER1L6_ENST00000399018.1_Missense_Mutation_p.M804T|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	804						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAAGCAGAAATGTCCTCCAAA	0.552000													8	100					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14107943	14107943	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:14107943T>C	ENST00000235372.7	+	8	4509	c.3653T>C	c.(3652-3654)gTg>gCg	p.V1218A	PRDM2_ENST00000311066.5_Missense_Mutation_p.V1218A|PRDM2_ENST00000343137.4_Missense_Mutation_p.V1017A|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.V1017A	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	1218						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CCAGATAAGGTGTGCACACAT	0.463000													38	136					0	0	1	0	0
ADORA2B	136	broad.mit.edu	37	17	15878301	15878301	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:15878301G>A	ENST00000304222.2	+	2	976	c.644G>A	c.(643-645)cGc>cAc	p.R215H		NM_000676.2	NP_000667.1	P29275	AA2BR_HUMAN	adenosine A2b receptor	215					activation of MAPK activity|cellular defense response|excretion|JNK cascade	integral to plasma membrane				breast(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)	9				UCEC - Uterine corpus endometrioid carcinoma (92;0.0855)	Defibrotide(DB04932)|Enprofylline(DB00824)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CAGCTTCAGCGCACTGAGCTG	0.517000													27	60					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36922666	36922666	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:36922666C>T	ENST00000373674.3	+	1	458	c.130C>T	c.(130-132)Cgg>Tgg	p.R44W		NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	44						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CAACCTCTACCGGGCCCAGGT	0.627000													20	38					0	0	1	0	0
CHFR	55743	broad.mit.edu	37	12	133448979	133448979	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133448979T>C	ENST00000266880.7	-	4	298	c.233_splice	c.e4-1	p.T79_splice	CHFR_ENST00000432561.2_Splice_Site_p.T79_splice|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000315585.7_Splice_Site_p.T79_splice|CHFR_ENST00000450056.2_Splice_Site_p.T79_splice|CHFR_ENST00000443047.2_Splice_Site_p.T79_splice			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	79	FHA.				cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		GTTCCACTGGTGCTGTAAAAA	0.378000													7	104					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769676	140769676	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140769676G>A	ENST00000519479.1	+	1	2225	c.2225G>A	c.(2224-2226)aGc>aAc	p.S742N	PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAACTACAGCGAGGGGACT	0.512000													107	308					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233995270	233995270	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233995270G>A	ENST00000359570.5	+	5	577	c.577G>A	c.(577-579)Gcc>Acc	p.A193T	INPP5D_ENST00000474278.1_3'UTR|INPP5D_ENST00000538935.1_Missense_Mutation_p.A193T			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	193					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CACTCAGCTCGCCCAGGACTC	0.453000													12	42					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8738683	8738683	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:8738683T>C	ENST00000311434.9	-	8	791	c.552A>G	c.(550-552)acA>acG	p.T184T	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	184					platelet activation	cytosol											AGGTCTCTGGTGTCTGCTGCG	0.647000													11	24					0	0	1	0	0
ZBTB26	57684	broad.mit.edu	37	9	125682060	125682060	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:125682060C>T	ENST00000373656.3	-	2	227	c.154G>A	c.(154-156)Gct>Act	p.A52T	ZBTB26_ENST00000373654.1_Missense_Mutation_p.A52T	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	52	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						GAACCTGCAGCAAACACAATT	0.353000													9	28					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27335415	27335415	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:27335415T>C	ENST00000376087.4	-	18	2017	c.1852A>G	c.(1852-1854)Act>Gct	p.T618A	ANKRD26_ENST00000436985.2_Missense_Mutation_p.T634A|ANKRD26_ENST00000376070.3_Missense_Mutation_p.T175A	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	617						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TCTTTTTCAGTGCTCTTTACT	0.393000													16	44					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14290832	14290832	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:14290832T>C	ENST00000344204.4	+	5	572	c.548T>C	c.(547-549)aTg>aCg	p.M183T	TRIO_ENST00000509967.2_Missense_Mutation_p.M134T|TRIO_ENST00000537187.1_Missense_Mutation_p.M183T	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	183	CRAL-TRIO.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					AAGACAAATATGGTCTCTTTA	0.363000													5	31					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5969030	5969030	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:5969030G>A	ENST00000399933.3	-	3	1200	c.1201C>T	c.(1201-1203)Cct>Tct	p.P401S	KIAA2026_ENST00000381461.2_Missense_Mutation_p.P401S	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	401										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AAAAACTGAGGACACAACCCC	0.423000													10	21					0	0	1	0	0
ZNF426	79088	broad.mit.edu	37	19	9644626	9644626	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9644626T>C	ENST00000593003.1	-	3	497	c.20A>G	c.(19-21)gAc>gGc	p.D7G	ZNF426_ENST00000535489.1_Missense_Mutation_p.D45G|ZNF426_ENST00000253115.2_Missense_Mutation_p.D45G|ZNF426_ENST00000589289.1_Missense_Mutation_p.D45G			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						AGCCACATCGTCAAAGGTCAC	0.522000													11	140					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5541181	5541181	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:5541181C>T	ENST00000382368.3	-	3	842	c.719G>A	c.(718-720)gGc>gAc	p.G240D	FBXL18_ENST00000453700.3_Missense_Mutation_p.G240D	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	240									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GTTGATGTAGCCGGGGGCCAG	0.652000													13	32					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106850954	106850954	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:106850954A>G	ENST00000228347.4	+	21	2554	c.2332A>G	c.(2332-2334)Acg>Gcg	p.T778A	POLR3B_ENST00000539066.1_Missense_Mutation_p.T720A	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	778					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TGCTAAATGTACGTTGAAACG	0.408000													41	105					0	0	1	0	0
ANP32E	81611	broad.mit.edu	37	1	150201458	150201458	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:150201458C>T	ENST00000314136.8	-	4	809	c.440G>A	c.(439-441)gGa>gAa	p.G147E	ANP32E_ENST00000369114.5_Intron|ANP32E_ENST00000369119.3_Missense_Mutation_p.G99E|ANP32E_ENST00000369115.2_Intron|ANP32E_ENST00000436748.2_Missense_Mutation_p.G106E|ANP32E_ENST00000369116.4_Intron|ANP32E_ENST00000533654.1_Intron	NM_001136478.2|NM_030920.3	NP_001129950.1|NP_112182.1	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	147	LRRCT.					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity			breast(3)|endometrium(3)|lung(7)|skin(1)|urinary_tract(1)	15	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGATCAAATCCATCTAAGTA	0.378000													24	78					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140724107	140724107	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140724107C>A	ENST00000253812.6	+	1	507	c.507C>A	c.(505-507)aaC>aaA	p.N169K	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1												p.N169K(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTGCAGAACTACAAGCTTA	0.493000													41	151					1.7489e-18	1.84115e-18	1	1	0
CNOT11	55571	broad.mit.edu	37	2	101883179	101883179	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:101883179A>G	ENST00000289382.3	+	5	1239	c.1076A>G	c.(1075-1077)cAt>cGt	p.H359R		NM_017546.4	NP_060016.3			CCR4-NOT transcription complex, subunit 11																		CTTGTCTACCATATTGGCCTC	0.423000													6	175					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145558913	145558913	+	Nonsense_Mutation	SNP	C	C	T	rs151076205		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:145558913C>T	ENST00000355594.4	+	7	619	c.532C>T	c.(532-534)Cga>Tga	p.R178*	ANKRD35_ENST00000544626.1_3'UTR	NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	178										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGAGGCGCCCGAGTTAATGT	0.552000													35	141					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102074490	102074490	+	Silent	SNP	G	G	A	rs147153195		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:102074490G>A	ENST00000369138.1	+	3	1009	c.519G>A	c.(517-519)acG>acA	p.T173T	GRIK2_ENST00000369134.4_Silent_p.T124T|GRIK2_ENST00000413795.1_Silent_p.T173T|GRIK2_ENST00000421544.1_Silent_p.T173T|GRIK2_ENST00000358361.3_Silent_p.T173T|GRIK2_ENST00000318991.6_Silent_p.T173T|GRIK2_ENST00000369137.3_Silent_p.T173T	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	173					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AAACCGTCACGGTTGTGTATG	0.398000													13	59					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22843857	22843857	+	Silent	SNP	C	C	T	rs148077022	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22843857C>T	ENST00000404138.1	+	14	3244	c.2733C>T	c.(2731-2733)caC>caT	p.H911H	ZBTB40_ENST00000375647.4_Silent_p.H911H|ZBTB40_ENST00000374651.4_Silent_p.H799H	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	911					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TGTCCCGCCACGTGAGGACCC	0.532000													38	104					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33764535	33764535	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:33764535C>T	ENST00000216968.4	+	4	718	c.636C>T	c.(634-636)gtC>gtT	p.V212V	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	212					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CTTCGCTGGTCCTGGGCGTCC	0.547000													13	25					0	0	1	0	0
C7orf10	79783	broad.mit.edu	37	7	40228095	40228095	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:40228095A>G	ENST00000309930.5	+	4	273	c.247_splice	c.e4-1	p.G83_splice	C7orf10_ENST00000335693.4_Splice_Site_p.G83_splice|C7orf10_ENST00000540834.1_Splice_Site_p.G76_splice|C7orf10_ENST00000401647.2_Splice_Site_p.G83_splice	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	83							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						TATTTTCAGGAGCTGGTGATG	0.378000													9	22					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39087709	39087709	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:39087709A>G	ENST00000591517.1	-	25	1934	c.1906T>C	c.(1906-1908)Tgg>Cgg	p.W636R	MAP4K1_ENST00000586296.1_Intron|MAP4K1_ENST00000396857.2_Missense_Mutation_p.W636R|MAP4K1_ENST00000589130.1_Missense_Mutation_p.W632R|CTB-186G2.1_ENST00000589557.1_RNA	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	636	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCTGGTACCACTGAAGCAGG	0.597000													37	105					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10478977	10478977	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10478977C>T	ENST00000525621.1	-	4	792	c.311G>A	c.(310-312)cGc>cAc	p.R104H	TYK2_ENST00000524462.1_Intron|TYK2_ENST00000529370.1_Missense_Mutation_p.R104H|TYK2_ENST00000264818.6_Missense_Mutation_p.R104H	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	104	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.R104L(1)		breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCACCTTATGCGGAAATATAG	0.552000													5	238					0	0	1	0	0
KIAA0391	9692	broad.mit.edu	37	14	35742694	35742694	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:35742694A>G	ENST00000557565.1	+	8	2055	c.1674A>G	c.(1672-1674)atA>atG	p.I558M	KIAA0391_ENST00000604948.1_Missense_Mutation_p.I463M|KIAA0391_ENST00000534898.4_Missense_Mutation_p.I558M|KIAA0391_ENST00000605870.1_Missense_Mutation_p.I186M|KIAA0391_ENST00000603544.1_Missense_Mutation_p.I542M|KIAA0391_ENST00000250377.7_Missense_Mutation_p.I463M|KIAA0391_ENST00000321130.10_Missense_Mutation_p.I542M			O15091	MRRP3_HUMAN	KIAA0391	558					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CGTGGCACATACCATATGATG	0.408000													12	43					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	65983808	65983808	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:65983808T>C	ENST00000443035.3	-	23	3336	c.3121A>G	c.(3121-3123)Aca>Gca	p.T1041A	DENND4A_ENST00000431932.2_Missense_Mutation_p.T998A	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	998					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						GTTTCATTTGTATCTTCAAGA	0.338000													5	16					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769809	50769809	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:50769809T>C	ENST00000216923.4	-	6	1271	c.922A>G	c.(922-924)Atc>Gtc	p.I308V	ZFP64_ENST00000346617.4_Missense_Mutation_p.I254V|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.I306V|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371518.2_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						CTGTGCTTGATACGGATGTGC	0.572000													29	82					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637733	158637733	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:158637733A>G	ENST00000368148.3	-	15	2133	c.1953T>C	c.(1951-1953)ggT>ggC	p.G651G	SPTA1_ENST00000368147.3_Silent_p.G651G	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	651					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGGCATAGTGACCACCCTCAA	0.473000													24	97					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390427	45390427	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:45390427G>A	ENST00000371438.1	+	2	514	c.156G>A	c.(154-156)caG>caA	p.Q52Q	RUNX2_ENST00000541979.1_Silent_p.Q120Q|RUNX2_ENST00000371436.6_Silent_p.Q52Q|RUNX2_ENST00000465038.2_Silent_p.Q52Q|RUNX2_ENST00000359524.5_Silent_p.Q38Q|RUNX2_ENST00000576263.1_Silent_p.Q52Q|RUNX2_ENST00000371432.3_Silent_p.Q38Q|RUNX2_ENST00000352853.5_Silent_p.Q120Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	52	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						aacagcagcagcaacagcagc	0.716000													26	74					0	0	1	0	0
UCN3	114131	broad.mit.edu	37	10	5415734	5415734	+	Silent	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:5415734C>G	ENST00000380433.3	+	2	279	c.51C>G	c.(49-51)ggC>ggG	p.G17G		NM_053049.2	NP_444277.2	Q969E3	UCN3_HUMAN	urocortin 3	17						extracellular region	hormone activity			endometrium(1)|large_intestine(1)	2						TCCTGGGGGGCCCCAGGACAG	0.637000													5	87					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10670071	10670071	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10670071G>A	ENST00000312962.6	-	12	1195	c.1176C>T	c.(1174-1176)gaC>gaT	p.D392D	KRI1_ENST00000361821.5_Silent_p.D388D	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	392	Glu-rich.									NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGTCGAAGTCGTCTTCAAGGT	0.587000													24	60					0	0	1	0	0
DTX2	113878	broad.mit.edu	37	7	76112069	76112069	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:76112069C>T	ENST00000324432.5	+	5	1023	c.513C>T	c.(511-513)agC>agT	p.S171S	DTX2_ENST00000307569.8_Silent_p.S171S|DTX2_ENST00000413936.2_Silent_p.S171S|DTX2_ENST00000446600.1_Silent_p.S80S|DTX2_ENST00000446820.2_Silent_p.S171S|DTX2_ENST00000430490.2_Silent_p.S171S	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	171	WWE 2.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding	p.S171S(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						TCTGCCGCAGCGTGCGGCGCC	0.652000													23	52					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20073950	20073950	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:20073950A>G	ENST00000276390.2	+	11	1145	c.1105A>G	c.(1105-1107)Act>Gct	p.T369A		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	369					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		CCCAGACTTGACTGGCTACAT	0.498000													11	86					0	0	1	0	0
MPP1	4354	broad.mit.edu	37	X	154014572	154014572	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:154014572A>T	ENST00000413259.3	-	7	886	c.494T>A	c.(493-495)aTc>aAc	p.I165N	MPP1_ENST00000393531.1_Missense_Mutation_p.I175N|MPP1_ENST00000369534.3_Missense_Mutation_p.I195N|MPP1_ENST00000462825.1_5'UTR	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	195	SH3.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATCCTTGTTGATAATCTGGAT	0.517000													9	371					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6680033	6680033	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6680033A>G	ENST00000309577.6	-	38	5969		c.e38+1		CHD4_ENST00000544040.1_Splice_Site|CHD4_ENST00000544484.1_Splice_Site|CHD4_ENST00000357008.2_Splice_Site			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AAATGGTCCTACCTGCTGTGG	0.527000													57	228					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233406216	233406216	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233406216G>A	ENST00000389494.3	+	5	504	c.483G>A	c.(481-483)tgG>tgA	p.W161*	CHRNG_ENST00000389492.3_Intron	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	161					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCTTCGACTGGCAGAACTGCT	0.582000													6	181					0	0	1	0	0
ALDH3A1	218	broad.mit.edu	37	17	19645443	19645443	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:19645443C>T	ENST00000457500.2	-	4	892	c.563G>A	c.(562-564)gGc>gAc	p.G188D	ALDH3A1_ENST00000395555.3_Missense_Mutation_p.G188D|ALDH3A1_ENST00000225740.6_Missense_Mutation_p.G188D|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.G188D|ALDH3A1_ENST00000494157.2_Missense_Mutation_p.G115D	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	188					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	CCCCGTGCTGCCCGTGTACAG	0.587000													36	67					0	0	1	0	0
SERTAD3	29946	broad.mit.edu	37	19	40947495	40947495	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40947495G>A	ENST00000322354.3	-	2	989	c.493C>T	c.(493-495)Cgg>Tgg	p.R165W	SERTAD3_ENST00000392028.4_Missense_Mutation_p.R165W	NM_203344.2	NP_976219.1	Q9UJW9	SRTD3_HUMAN	SERTA domain containing 3	165					negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(4)|lung(2)	7			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGTGGGGCCCGTGCAGGCTCC	0.527000													60	142					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38406835	38406835	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:38406835C>T	ENST00000351773.3	+	8	1586	c.756C>T	c.(754-756)ttC>ttT	p.F252F	ZNF37A_ENST00000361085.4_Silent_p.F252F	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	252						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						GAACATTTTTCAGTGAAAAAT	0.358000													4	109					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45719118	45719118	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:45719118G>A	ENST00000216214.3	+	4	944	c.110G>A	c.(109-111)gGc>gAc	p.G37D	FAM118A_ENST00000441876.2_Missense_Mutation_p.G37D|FAM118A_ENST00000405673.1_Missense_Mutation_p.G37D	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	37						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		ATCGGGACTGGCGTCAGCGCA	0.552000													32	70					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121219311	121219311	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:121219311C>T	ENST00000297848.3	+	10	1439	c.1169C>T	c.(1168-1170)aCc>aTc	p.T390I	COL14A1_ENST00000537875.1_Missense_Mutation_p.T390I|COL14A1_ENST00000247781.3_Missense_Mutation_p.T295I|COL14A1_ENST00000309791.4_Missense_Mutation_p.T390I|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	390	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TATTATCCTACCAGGGGTGGA	0.398000													9	44					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890411	2890411	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:2890411A>G	ENST00000380698.4	-	7	1206	c.1117T>C	c.(1117-1119)Ttc>Ctc	p.F373L		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	373					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GGCGATGAGAACCTGCCACAG	0.537000													10	49					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	466859	466859	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:466859C>T	ENST00000512944.1	+	13	2273	c.2084C>T	c.(2083-2085)gCg>gTg	p.A695V	EXOC3_ENST00000315013.5_Missense_Mutation_p.A695V|CTD-2228K2.5_ENST00000510714.1_Intron	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	706					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CACATCGGTGCGCTGCTGGCT	0.657000													21	50					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3240680	3240680	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:3240680T>C	ENST00000355072.5	+	66	9335	c.9190T>C	c.(9190-9192)Tcc>Ccc	p.S3064P		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	3064					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TGTCAGCGCGTCCACCAGCCC	0.617000													7	22					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126133465	126133465	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:126133465G>A	ENST00000373631.3	+	8	2045	c.2044G>A	c.(2044-2046)Gct>Act	p.A682T	CRB2_ENST00000359999.3_Missense_Mutation_p.A682T|CRB2_ENST00000373629.2_Missense_Mutation_p.A350T	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	682	Laminin G-like 2.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						TCGGGAGTCCGCTGGCCTGTT	0.612000													72	231					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2737027	2737027	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:2737027G>A	ENST00000455372.2	-	2	434	c.229C>T	c.(229-231)Cta>Tta	p.L77L	SLC39A3_ENST00000545664.1_Intron|SLC39A3_ENST00000269740.4_Intron|AC006538.4_ENST00000586572.1_Intron	NM_213568.1	NP_998733.1	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	0						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCTGCTAGTGCCCAGGGA	0.557000													15	27					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6611559	6611559	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:6611559C>T	ENST00000285599.3	+	13	2077	c.2041C>T	c.(2041-2043)Cgc>Tgc	p.R681C	MAN2B2_ENST00000504248.1_Missense_Mutation_p.R630C|MAN2B2_ENST00000504960.1_3'UTR	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	681					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						GTATGCAATCCGCTCCCGGCT	0.572000													25	88					0	0	1	0	0
GPC2	221914	broad.mit.edu	37	7	99769416	99769416	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99769416T>C	ENST00000292377.2	-	7	1323	c.1156A>G	c.(1156-1158)Aac>Gac	p.N386D	GPC2_ENST00000471050.1_5'UTR	NM_152742.1	NP_689955.1	Q8N158	GPC2_HUMAN	glypican 2	386						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(3)	18	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGTGCAGGTTGGTGCCTGCG	0.771000													7	10					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40936504	40936504	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:40936504C>T	ENST00000246914.5	+	4	1098	c.1077C>T	c.(1075-1077)taC>taT	p.Y359Y		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	359	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TGGACGTGTACGCGTTCGGCA	0.587000													14	34					0	0	1	0	0
SEPT5	5413	broad.mit.edu	37	22	19709193	19709193	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:19709193A>G	ENST00000438754.2	+	8	1055	c.775A>G	c.(775-777)Aac>Gac	p.N259D	SEPT5_ENST00000406395.1_Missense_Mutation_p.N250D|SEPT5_ENST00000383045.3_Missense_Mutation_p.N259D|SEPT5_ENST00000455784.2_Missense_Mutation_p.N250D	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	250					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					TATAGGCAGCAACACGGTGGT	0.642000													7	117					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48429034	48429034	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:48429034C>T	ENST00000224605.2	-	2	1117	c.852G>A	c.(850-852)gcG>gcA	p.A284A		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	284					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CGCGGGGGTCCGCTGAGTTGT	0.726000													9	23					0	0	1	0	0
SCLY	51540	broad.mit.edu	37	2	238990440	238990440	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:238990440C>T	ENST00000254663.6	+	5	741	c.599C>T	c.(598-600)aCc>aTc	p.T200I	SCLY_ENST00000409736.2_Missense_Mutation_p.T192I|SCLY_ENST00000422984.2_Missense_Mutation_p.T98I|SCLY_ENST00000373332.3_Missense_Mutation_p.T110I|SCLY_ENST00000555827.1_Missense_Mutation_p.T192I|SCLY_ENST00000429612.2_Intron	NM_016510.5	NP_057594.4	Q96I15	SCLY_HUMAN	selenocysteine lyase	192					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	22		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		CGCCTCGTGACCATCATGCTG	0.572000													21	61					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21521706	21521706	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21521706G>A	ENST00000222584.3	+	5	2290	c.2072G>A	c.(2071-2073)aGt>aAt	p.S691N		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	691					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						TTCACACGGAGTGATGAGCTC	0.368000													6	150					0	0	1	0	0
MITF	4286	broad.mit.edu	37	3	69987103	69987103	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:69987103A>G	ENST00000352241.4	+	3	648	c.485A>G	c.(484-486)aAc>aGc	p.N162S	MITF_ENST00000394351.3_Missense_Mutation_p.N55S|MITF_ENST00000472437.1_Missense_Mutation_p.N110S|MITF_ENST00000394348.1_3'UTR|MITF_ENST00000314589.5_Missense_Mutation_p.N146S|MITF_ENST00000531774.1_Intron|MITF_ENST00000314557.6_Missense_Mutation_p.N55S|MITF_ENST00000328528.6_Missense_Mutation_p.N161S|MITF_ENST00000448226.2_Missense_Mutation_p.N162S|MITF_ENST00000394355.2_Missense_Mutation_p.N137S	NM_198159.2	NP_937802.1	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	162					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		CCATGTCCAAACCAGCCTGGC	0.522000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						21	76					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20403872	20403872	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20403872G>A	ENST00000285600.4	+	1	106	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTACTTTTGGGACTCTCTAAT	0.343000													60	452					0	0	1	0	0
NCOA4	8031	broad.mit.edu	37	10	51579242	51579242	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:51579242T>C	ENST00000452682.1	+	3	401	c.149T>C	c.(148-150)gTt>gCt	p.V50A	NCOA4_ENST00000438493.1_Missense_Mutation_p.V50A|NCOA4_ENST00000430396.2_Intron|NCOA4_ENST00000414907.2_Intron|NCOA4_ENST00000344348.6_Missense_Mutation_p.V34A|NCOA4_ENST00000443446.1_Missense_Mutation_p.V34A|NCOA4_ENST00000374082.1_Missense_Mutation_p.V34A|NCOA4_ENST00000498586.1_Intron|NCOA4_ENST00000374087.4_Missense_Mutation_p.V34A	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	34					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						ATTGGTGGAGTTCTCCGGGCT	0.478000			T	RET	papillary thyroid								49	163					0	0	1	0	0
TMEM66	51669	broad.mit.edu	37	8	29927269	29927269	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:29927269C>T	ENST00000256255.6	-	3	846	c.589G>A	c.(589-591)Ggg>Agg	p.G197R	TMEM66_ENST00000536273.1_Missense_Mutation_p.G25R|TMEM66_ENST00000545648.1_Missense_Mutation_p.G25R	NM_016127.4	NP_057211.4	Q96BY9	TMM66_HUMAN	transmembrane protein 66	197						integral to membrane				endometrium(2)|large_intestine(1)|lung(11)	14				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		GAATACTGCCCGTCACTCAGG	0.502000													59	99					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33195265	33195265	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:33195265G>A	ENST00000309558.3	-	5	1276	c.859C>T	c.(859-861)Cgg>Tgg	p.R287W		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	287					cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TGGAGCAGCCGTGATCCTGGT	0.532000													23	49					0	0	1	0	0
USP36	57602	broad.mit.edu	37	17	76803168	76803168	+	Missense_Mutation	SNP	G	G	A	rs143765903	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:76803168G>A	ENST00000312010.6	-	14	2282	c.1958C>T	c.(1957-1959)aCg>aTg	p.T653M	USP36_ENST00000449938.2_Missense_Mutation_p.T353M|USP36_ENST00000542802.2_Missense_Mutation_p.T653M	NM_025090.3	NP_079366.3	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	653					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			ACTTGGCGGCGTTTTGGAGTG	0.607000													23	61					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102981475	102981475	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:102981475T>A	ENST00000504592.1	+	16	2450	c.2032T>A	c.(2032-2034)Tct>Act	p.S678T	BANK1_ENST00000322953.4_Missense_Mutation_p.S693T|BANK1_ENST00000428908.1_Missense_Mutation_p.S560T|BANK1_ENST00000508653.1_Missense_Mutation_p.S560T|BANK1_ENST00000444316.2_Missense_Mutation_p.S663T			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	693					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TGGGAAAATGTCTATGGATGA	0.453000													26	84					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707482	50707482	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:50707482G>A	ENST00000330943.4	-	4	957	c.786C>T	c.(784-786)ggC>ggT	p.G262G	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	262					cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						AGTAGCGATGGCCCTCCCGGG	0.721000													14	45					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90028906	90028906	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:90028906T>C	ENST00000428670.3	-	4	985	c.529A>G	c.(529-531)Aag>Gag	p.K177E	ATP2B1_ENST00000348959.3_Missense_Mutation_p.K177E|ATP2B1_ENST00000359142.3_Missense_Mutation_p.K177E|ATP2B1_ENST00000261173.2_Missense_Mutation_p.K177E			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	177					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						TGTTTTTCCTTACTCCAGTCA	0.448000													34	137					0	0	1	0	0
ECI1	1632	broad.mit.edu	37	16	2290114	2290114	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2290114G>A	ENST00000301729.4	-	7	822	c.775C>T	c.(775-777)Cga>Tga	p.R259*	ECI1_ENST00000562238.1_Nonsense_Mutation_p.R242*|ECI1_ENST00000570258.1_Nonsense_Mutation_p.R200*	NM_001919.3	NP_001910.2	P42126	ECI1_HUMAN	enoyl-CoA delta isomerase 1	259					fatty acid beta-oxidation	mitochondrial matrix	dodecenoyl-CoA delta-isomerase activity			endometrium(1)|large_intestine(2)|lung(6)	9						GTGGCCTTTCGCATCATGGCC	0.557000													17	36					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77984303	77984303	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:77984303G>T	ENST00000310924.2	-	3	550	c.435C>A	c.(433-435)gcC>gcA	p.A145A		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	145						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GAACACTCTGGGCCACCACCA	0.701000													13	15					0.00185496	0.00187323	1	1	0
PCM1	5108	broad.mit.edu	37	8	17814832	17814832	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:17814832T>C	ENST00000325083.8	+	12	2145	c.1706T>C	c.(1705-1707)gTt>gCt	p.V569A	PCM1_ENST00000519253.1_Missense_Mutation_p.V569A|PCM1_ENST00000524226.1_Missense_Mutation_p.V569A	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	569					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		GCACAGTGTGTTTCTAATAAT	0.368000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								13	170					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2547000	2547000	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2547000A>G	ENST00000567020.1	+	2	991	c.851A>G	c.(850-852)aAg>aGg	p.K284R	TBC1D24_ENST00000434757.2_Missense_Mutation_p.K284R|TBC1D24_ENST00000293970.5_Missense_Mutation_p.K284R|RP11-20I23.1_ENST00000564543.1_Missense_Mutation_p.K284R	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	284					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						TCCCCTGAGAAGCTGCTGGAG	0.607000													26	96					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50332907	50332907	+	Nonsense_Mutation	SNP	C	C	A	rs142241553		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:50332907C>A	ENST00000394697.2	+	8	1381	c.1041C>A	c.(1039-1041)tgC>tgA	p.C347*	ADCY7_ENST00000537579.1_Nonsense_Mutation_p.C347*|ADCY7_ENST00000254235.3_Nonsense_Mutation_p.C347*|ADCY7_ENST00000538642.1_Nonsense_Mutation_p.C347*|ADCY7_ENST00000566433.2_Nonsense_Mutation_p.C347*|ADCY7_ENST00000564044.1_3'UTR			P51828	ADCY7_HUMAN	adenylate cyclase 7	347	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCCGGAACTGCGTGAAGATGG	0.657000													24	63					1.75199e-13	1.82818e-13	1	1	0
ZNF777	27153	broad.mit.edu	37	7	149152363	149152363	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:149152363G>A	ENST00000247930.4	-	2	1074	c.751C>T	c.(751-753)Ctg>Ttg	p.L251L		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CGCCTCTGCAGCAGCCCATAC	0.567000													17	186					0	0	1	0	0
PIK3R2	5296	broad.mit.edu	37	19	18271310	18271310	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:18271310T>C	ENST00000593731.1	+	3	912	c.352T>C	c.(352-354)Ttc>Ctc	p.F118L	PIK3R2_ENST00000222254.7_Missense_Mutation_p.F118L			O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	118	Rho-GAP.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(3)|pancreas(1)|stomach(1)	24						GCCCGAGCAGTTCTCCCCACC	0.612000													18	51					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120582208	120582208	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:120582208G>A	ENST00000300648.6	-	42	5409	c.5397C>T	c.(5395-5397)cgC>cgT	p.R1799R		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1799					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGGCCCGCGCGCAGGGCGG	0.622000													24	56					0	0	1	0	0
FBXO39	162517	broad.mit.edu	37	17	6683941	6683941	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:6683941C>T	ENST00000321535.4	+	2	884	c.754C>T	c.(754-756)Cgg>Tgg	p.R252W		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	252										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						CAGCACCCTCCGGACCATCAA	0.542000													32	99					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86697774	86697774	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:86697774C>T	ENST00000441037.2	+	3	333	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C	AGBL1_ENST00000421325.2_Missense_Mutation_p.R80C	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	80					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CTGGGCTCTGCGTGTGTTTGC	0.537000													8	27					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41552141	41552141	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:41552141G>A	ENST00000396942.1	-	28	3379	c.3296C>T	c.(3295-3297)gCc>gTc	p.A1099V	ANK1_ENST00000347528.4_Missense_Mutation_p.A1099V|ANK1_ENST00000396945.1_Missense_Mutation_p.A1099V|ANK1_ENST00000352337.4_Missense_Mutation_p.A1099V|ANK1_ENST00000265709.8_Missense_Mutation_p.A1140V|ANK1_ENST00000379758.2_Missense_Mutation_p.A1099V|ANK1_ENST00000289734.7_Missense_Mutation_p.A1099V			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1099					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTTGGTGACGGCATTCTCCGG	0.647000													11	44					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53276160	53276160	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:53276160T>C	ENST00000462138.1	-	2	294	c.206A>G	c.(205-207)gAc>gGc	p.D69G	TKT_ENST00000423516.1_Missense_Mutation_p.D69G|TKT_ENST00000296289.6_Missense_Mutation_p.D22G|TKT_ENST00000423525.2_Missense_Mutation_p.D69G			P29401	TKT_HUMAN	transketolase	69					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	CACAAAGCGGTCATTGTGCGG	0.602000													22	65					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67993103	67993103	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:67993103A>G	ENST00000397942.3	+	2	1515	c.1199A>G	c.(1198-1200)aAc>aGc	p.N400S	SOCS6_ENST00000582322.1_Missense_Mutation_p.N400S	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	400	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				AAGCTAGCAAACGTGCCAGAT	0.468000													5	100					0	0	1	0	0
GLO1	2739	broad.mit.edu	37	6	38670782	38670782	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:38670782G>T	ENST00000373365.4	-	1	135	c.49C>A	c.(49-51)Ctc>Atc	p.L17I		NM_006708.2	NP_006699.2	Q04760	LGUL_HUMAN	glyoxalase I	17					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	6					Glutathione(DB00143)	CAGCAACTGAGGGCGGCCTCG	0.697000													12	32					3.45872e-05	3.53152e-05	1	1	0
NPR3	4883	broad.mit.edu	37	5	32724858	32724858	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:32724858A>G	ENST00000265074.8	+	2	1167	c.824A>G	c.(823-825)cAc>cGc	p.H275R	NPR3_ENST00000415685.2_Missense_Mutation_p.H59R|NPR3_ENST00000415167.2_Missense_Mutation_p.H275R|NPR3_ENST00000434067.2_Missense_Mutation_p.H59R	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	275					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	CTGGTGGCGCACAGGCATGGC	0.537000													20	46					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47360108	47360108	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47360108C>T	ENST00000400314.1	+	15	1412	c.1074C>T	c.(1072-1074)aaC>aaT	p.N358N	PCBP3_ENST00000400304.1_Silent_p.N348N|PCBP3_ENST00000468429.1_3'UTR|PCBP3_ENST00000400310.1_Silent_p.N338N|PCBP3_ENST00000400309.1_Silent_p.N357N|PCBP3_ENST00000449640.1_Silent_p.N358N|PCBP3_ENST00000400308.1_Silent_p.N332N			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	358					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding	p.N326N(1)|p.N358N(1)		biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		ATCTCATCAACGCCAGGTGAG	0.627000													15	48					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119925634	119925634	+	Silent	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:119925634A>T	ENST00000361035.4	+	4	550	c.267A>T	c.(265-267)gcA>gcT	p.A89A	HAO2_ENST00000325945.3_Silent_p.A76A	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	76	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TTTGTATCGCACCCACAGGGT	0.567000													9	21					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95527004	95527004	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:95527004T>A	ENST00000356884.6	-	1	90	c.23A>T	c.(22-24)gAg>gTg	p.E8V	BICD2_ENST00000375512.3_Missense_Mutation_p.E8V	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	8					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CGCGTACTCCTCCTCCTCCGA	0.741000													4	15					0	0	1	0	0
NSMCE1	197370	broad.mit.edu	37	16	27238046	27238046	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27238046T>C	ENST00000361439.4	-	6	694	c.595A>G	c.(595-597)Atc>Gtc	p.I199V	NSMCE1_ENST00000565384.1_5'UTR	NM_145080.3	NP_659547.2	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog (S. cerevisiae)	199					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)	7						GGTACCTGGATGAGGAGGCTG	0.642000													21	50					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159636044	159636044	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:159636044G>A	ENST00000297267.9	+	5	728	c.528G>A	c.(526-528)gcG>gcA	p.A176A	FNDC1_ENST00000340366.6_Silent_p.A176A	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	176	Fibronectin type-III 2.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TGTCCGTTGCGTGGAAGGCAC	0.562000													15	66					0	0	1	0	0
HCN2	610	broad.mit.edu	37	19	615973	615973	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:615973C>T	ENST00000251287.2	+	8	2222	c.2169C>T	c.(2167-2169)gtC>gtT	p.V723V	AC005559.2_ENST00000591847.1_RNA	NM_001194.3	NP_001185.3	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	723	Pro-rich.				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			endometrium(5)|lung(4)	9		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		cgccgcAGGTCACCTCGGCCA	0.751000													9	11					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907860	77907860	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:77907860C>T	ENST00000355300.6	-	2	563	c.389G>A	c.(388-390)cGc>cAc	p.R130H	LINGO1_ENST00000561030.1_Missense_Mutation_p.R124H	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	130					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						GAGCTTCAGGCGGTTGCTGCG	0.582000													17	31					0	0	1	0	0
LZTS3	9762	broad.mit.edu	37	20	3146964	3146964	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:3146964C>T	ENST00000329152.3	-	2	1899	c.502G>A	c.(502-504)Gta>Ata	p.V168I	LZTS3_ENST00000360342.3_Missense_Mutation_p.V168I|LZTS3_ENST00000337576.5_Missense_Mutation_p.V168I	NM_014731.2	NP_055546.1																					TTCTTGGGTACGACAGGCTTG	0.627000													11	43					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33017615	33017615	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:33017615T>C	ENST00000357505.6	-	7	1118	c.1014A>G	c.(1012-1014)gaA>gaG	p.E338E	N4BP2L2_ENST00000504114.1_Silent_p.E338E|N4BP2L2_ENST00000446957.2_Intron|N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000399396.3_Silent_p.E353E	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	0										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TATACACTTGTTCCTCTCTTA	0.358000													4	22					0	0	1	0	0
OR6C2	341416	broad.mit.edu	37	12	55846907	55846907	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:55846907A>G	ENST00000322678.1	+	1	910	c.910A>G	c.(910-912)Aag>Gag	p.K304E	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA	NM_054105.1	NP_473446.1	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C, member 2	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(5)|lung(8)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	23						TGACTCTATAAAGAGGATTGC	0.393000													11	53					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	153001628	153001628	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153001628A>G	ENST00000218104.3	+	3	1543	c.1144A>G	c.(1144-1146)Aca>Gca	p.T382A	U52111.14_ENST00000434284.1_RNA	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	382	ABC transmembrane type-1.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGCGAGCGCACAGAAGCCTT	0.627000													47	43					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2376055	2376055	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:2376055G>A	ENST00000202625.2	+	3	458	c.397G>A	c.(397-399)Gtt>Att	p.V133I	TGM6_ENST00000477505.1_Intron|TGM6_ENST00000381423.1_Missense_Mutation_p.V133I	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	133					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	GGGCGAGTTTGTTCTCCTTTT	0.567000													49	142					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25227119	25227119	+	RNA	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:25227119T>A	ENST00000551631.2	+	0	422					NR_001293.1																						GAAATAAGCATATATTGCAGA	0.363000													7	292					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182347240	182347240	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:182347240G>A	ENST00000397033.2	+	9	1333		c.e9-1			NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)						blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TTTTGGGACAGCTTGGATCGT	0.473000													6	311					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43157136	43157136	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:43157136T>C	ENST00000522175.2	+	0	697							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ATACTTGCTGTACGTTGTGGA	0.318000													13	81					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34515747	34515747	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:34515747C>T	ENST00000374012.3	+	14	2179	c.2050C>T	c.(2050-2052)Ctg>Ttg	p.L684L	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	684					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					CATGGGATTACTGGAAGAAAA	0.438000													5	191					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30602795	30602795	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:30602795A>T	ENST00000358107.4	-	10	1881	c.1882T>A	c.(1882-1884)Ttt>Att	p.F628I	MTPAP_ENST00000488290.1_5'UTR|MTPAP_ENST00000263063.3_Missense_Mutation_p.F498I			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	498					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						AAATCTACAAATTTTTGCAGC	0.418000													29	80					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43534459	43534459	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:43534459T>C	ENST00000282041.5	-	2	943	c.909A>G	c.(907-909)caA>caG	p.Q303Q		NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	303					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						CCAGCAGCAGTTGCTTCCTAC	0.418000													6	163					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1580919	1580919	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1580919G>A	ENST00000572621.1	-	13	2189	c.1924C>T	c.(1924-1926)Cgt>Tgt	p.R642C	PRPF8_ENST00000304992.6_Missense_Mutation_p.R642C			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	642						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GTAATGCCACGCATGAAAAAG	0.532000													60	104					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35351777	35351777	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35351777C>T	ENST00000373347.1	-	6	1764	c.1496G>A	c.(1495-1497)cGg>cAg	p.R499Q	DLGAP3_ENST00000235180.4_Missense_Mutation_p.R499Q			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	499					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GCTGTGGCTCCGCATGCGGAA	0.697000													10	19					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96956475	96956475	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:96956475A>G	ENST00000323853.5	-	19	2577	c.2500T>C	c.(2500-2502)Tac>Cac	p.Y834H	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	834	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TCTGGACTGTACACCTGGGTG	0.488000													22	189					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48815311	48815311	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:48815311A>G	ENST00000314191.2	-	27	3143	c.3087T>C	c.(3085-3087)tgT>tgC	p.C1029C	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.C1029C	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	1029					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TACACCGACCACAAAAATCTC	0.393000								Non-homologous end-joining					5	69					0	0	1	0	0
GABRR3	200959	broad.mit.edu	37	3	97705720	97705720	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:97705720T>C	ENST00000472788.1	-	0	1212					NM_001105580.2	NP_001099050.1	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 3						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			large_intestine(2)|lung(1)	3						CATGAAGTCTTCTGAGTTTAG	0.433000													6	8					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9044645	9044645	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:9044645C>T	ENST00000382496.5	-	22	3610	c.2945G>A	c.(2944-2946)gGc>gAc	p.G982D	CTD-2215L10.1_ENST00000506519.1_RNA	NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	982					cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GAGGAGGCAGCCGAGGATGGA	0.557000													34	90					0	0	1	0	0
AE000661.37	0	broad.mit.edu	37	14	22933207	22933207	+	RNA	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:22933207A>G	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA|TRDC_ENST00000390477.2_RNA																							CATAGTTCATACCGAGAAGGT	0.453000													3	33					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46787171	46787171	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46787171G>A	ENST00000262738.3	-	16	6161	c.6162C>T	c.(6160-6162)ggC>ggT	p.G2054G		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2054					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTTTGGGACAGCCATTGTAGA	0.612000											OREG0026656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	39					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118621703	118621703	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:118621703T>C	ENST00000354673.2	-	9	1337	c.957A>G	c.(955-957)cgA>cgG	p.R319R	IGSF11_ENST00000441144.2_Silent_p.R295R|IGSF11_ENST00000491903.1_Silent_p.R292R|IGSF11_ENST00000393775.2_Silent_p.R320R|IGSF11_ENST00000425327.2_Silent_p.R319R|IGSF11_ENST00000489689.1_Silent_p.R296R	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	320					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGCTCCAGTATCGACTGTTGT	0.453000													4	155					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6524291	6524291	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:6524291G>T	ENST00000361413.3	-	7	1490	c.1132C>A	c.(1132-1134)Ctg>Atg	p.L378M	KIAA0753_ENST00000542606.1_Missense_Mutation_p.L79M|KIAA0753_ENST00000572370.1_Missense_Mutation_p.L79M	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	378						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TTTGGTGACAGTTTCTTTTCC	0.373000													8	54					0.0381472	0.0383256	1	1	0
PLCXD3	345557	broad.mit.edu	37	5	41313724	41313724	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:41313724T>G	ENST00000377801.3	-	3	1035	c.961A>C	c.(961-963)Act>Cct	p.T321P	PLCXD3_ENST00000328457.3_Missense_Mutation_p.T321P			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	321					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TGCTATCAAGTGTTGGCTTCT	0.398000													15	56					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16035644	16035644	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16035644A>G	ENST00000326742.7	-	5	575	c.574T>C	c.(574-576)Ttt>Ctt	p.F192L	CYP4F11_ENST00000248041.7_Missense_Mutation_p.F192L|CYP4F11_ENST00000402119.3_Missense_Mutation_p.F192L			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	192					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						ATGTGTTCAAACATGTCCAGT	0.537000													30	76					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107281	121107281	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:121107281C>T	ENST00000295228.3	+	2	1101	c.1055C>T	c.(1054-1056)aCg>aTg	p.T352M		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	352					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				TCCTTCCACACGGCTGTGGTG	0.622000													26	65					0	0	1	0	0
BIRC8	112401	broad.mit.edu	37	19	53793236	53793236	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:53793236A>T	ENST00000426466.1	-	1	1639	c.392T>A	c.(391-393)aTa>aAa	p.I131K		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	131					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		TTCCTCCATTATTTTCTTAAC	0.378000													4	194					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000439954.2_Silent_p.G100G|FRG1B_ENST00000358464.4_Silent_p.G95G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													6	103					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97715756	97715756	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:97715756A>G	ENST00000275053.4	-	8	1085	c.820T>C	c.(820-822)Tac>Cac	p.Y274H	MMS22L_ENST00000506256.1_5'UTR|MMS22L_ENST00000369251.2_Missense_Mutation_p.Y274H	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	274					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						ACCTTGTCGTACCTGTTGAGT	0.328000													3	15					0	0	1	0	0
CUL2	8453	broad.mit.edu	37	10	35351986	35351986	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:35351986T>C	ENST00000374748.1	-	4	437	c.124A>G	c.(124-126)Atc>Gtc	p.I42V	CUL2_ENST00000374742.1_Missense_Mutation_p.I42V|CUL2_ENST00000537177.1_Missense_Mutation_p.I61V|CUL2_ENST00000374751.3_Missense_Mutation_p.I42V|CUL2_ENST00000374749.3_Missense_Mutation_p.I42V|CUL2_ENST00000602371.1_De_novo_Start_InFrame|CUL2_ENST00000374746.1_Missense_Mutation_p.I42V			Q13617	CUL2_HUMAN	cullin 2	42					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|prostate(2)|skin(1)|urinary_tract(2)	31						AAAGCATAGATATCTCTAGTT	0.294000													10	40					0	0	1	0	0
SLC11A2	4891	broad.mit.edu	37	12	51390601	51390601	+	Splice_Site	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:51390601T>G	ENST00000394904.3	-	9	966	c.918_splice	c.e9+1	p.K306_splice	SLC11A2_ENST00000262052.5_Splice_Site_p.K277_splice|SLC11A2_ENST00000262051.7_Splice_Site_p.K277_splice|SLC11A2_ENST00000541174.2_Splice_Site_p.K277_splice|SLC11A2_ENST00000546743.1_Splice_Site_p.K198_splice|SLC11A2_ENST00000545993.2_Splice_Site_p.K273_splice|SLC11A2_ENST00000547198.1_Splice_Site_p.K277_splice|SLC11A2_ENST00000547688.1_Splice_Site_p.K306_splice	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	277					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						CTTGCTCACCTTGACTAAGGC	0.478000													8	96					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100893279	100893279	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:100893279G>A	ENST00000343933.5	-	7	1085	c.828C>T	c.(826-828)ccC>ccT	p.P276P	CORO2A_ENST00000375077.4_Silent_p.P276P	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	276					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				CGTCATAGAAGGGAAACAGCA	0.642000													5	43					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42169798	42169798	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:42169798A>G	ENST00000225983.6	-	8	1196	c.873T>C	c.(871-873)atT>atC	p.I291I	HDAC5_ENST00000586802.1_Silent_p.I290I|HDAC5_ENST00000393622.2_Silent_p.I290I|HDAC5_ENST00000336057.5_Silent_p.I290I			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	290					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		TAAAGGTGCTAATAACAGTCC	0.552000													15	32					0	0	1	0	0
TOP1	7150	broad.mit.edu	37	20	39729957	39729957	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:39729957T>C	ENST00000361337.2	+	13	1522	c.1272T>C	c.(1270-1272)atT>atC	p.I424I	RP1-1J6.2_ENST00000454626.1_RNA	NM_003286.2	NP_003277.1	P11387	TOP1_HUMAN	topoisomerase (DNA) I	424					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	AAGGTTCCATTAAATACATCA	0.433000			T	NUP98	AML*								18	48					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154315748	154315748	+	Missense_Mutation	SNP	A	A	G	rs148837394		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:154315748A>G	ENST00000368489.3	+	16	1712	c.1712A>G	c.(1711-1713)aAc>aGc	p.N571S		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	557					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGGACTTCAACAACATCCGC	0.577000													13	44					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16812423	16812423	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:16812423T>C	ENST00000355661.3	-	21	2984	c.2974A>G	c.(2974-2976)Acc>Gcc	p.T992A	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.T993A|PLEKHA7_ENST00000332954.4_5'UTR|PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.T992A			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	992					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						CCGCTGAGGGTCGCCAGCTCA	0.647000													5	17					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76091084	76091084	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:76091084T>C	ENST00000238667.4	+	3	1297	c.941T>C	c.(940-942)gTc>gCc	p.V314A	FLVCR2_ENST00000556856.1_Missense_Mutation_p.V62A|FLVCR2_ENST00000553587.1_Missense_Mutation_p.V62A|FLVCR2_ENST00000539311.1_Missense_Mutation_p.V109A|FLVCR2_ENST00000556241.1_3'UTR	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	314					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		GTGCTGCTTGTCATCACCTAT	0.453000													9	108					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28991197	28991197	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:28991197T>C	ENST00000359747.4	+	14	2227	c.2198T>C	c.(2197-2199)aTc>aCc	p.I733T	DSG4_ENST00000308128.4_Missense_Mutation_p.I714T|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	714					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTTTCAGAAATCTACACCAAC	0.607000													8	128					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185998	127185998	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:127185998T>C	ENST00000371124.3	-	1	384	c.188A>G	c.(187-189)tAc>tGc	p.Y63C		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	63						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CTCATACTTGTACAGGGCTTC	0.493000													67	74					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47536294	47536294	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47536294G>A	ENST00000300527.4	+	8	1008	c.904G>A	c.(904-906)Gtt>Att	p.V302I	COL6A2_ENST00000357838.4_Missense_Mutation_p.V302I|COL6A2_ENST00000310645.5_Missense_Mutation_p.V302I|COL6A2_ENST00000397763.1_Missense_Mutation_p.V302I|COL6A2_ENST00000409416.1_Missense_Mutation_p.V302I	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	302	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCCCCAGGGCGTTCCTGGCTT	0.667000													17	43					0	0	1	0	0
NT5C3B	115024	broad.mit.edu	37	17	39991346	39991346	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39991346G>A	ENST00000269534.8	-	4	281	c.180C>T	c.(178-180)atC>atT	p.I60I	NT5C3B_ENST00000521789.1_Silent_p.I35I|NT5C3B_ENST00000435506.2_Silent_p.I68I	NM_052935.4	NP_443167.4			5'-nucleotidase, cytosolic IIIB																		CCTCACTGATGATCTTGCTAT	0.428000													36	99					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72067080	72067080	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:72067080G>A	ENST00000265381.4	-	9	2148	c.1926C>T	c.(1924-1926)aaC>aaT	p.N642N		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	642	PID.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						TCAGGTCATCGTTGTACATGT	0.517000													47	164					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232601028	232601028	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:232601028T>C	ENST00000366630.1	-	8	2736	c.2378A>G	c.(2377-2379)aAa>aGa	p.K793R	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.K793R			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	793	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTTTTCTGATTTATGGGCTGC	0.483000													4	170					0	0	1	0	0
MIS12	79003	broad.mit.edu	37	17	5392753	5392753	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:5392753A>G	ENST00000381165.3	+	3	1124	c.571A>G	c.(571-573)Att>Gtt	p.I191V	MIS12_ENST00000573759.1_Missense_Mutation_p.I191V	NM_001258217.1|NM_001258219.1|NM_001258220.1|NM_024039.2	NP_001245146.1|NP_001245148.1|NP_001245149.1|NP_076944.1	Q9H081	MIS12_HUMAN	MIS12 kinetochore complex component	191					cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(2)	12						ACTACAGAACATTAGAGACAA	0.383000													4	174					0	0	1	0	0
SLC38A2	54407	broad.mit.edu	37	12	46764402	46764402	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:46764402A>G	ENST00000256689.5	-	4	651	c.207T>C	c.(205-207)ggT>ggC	p.G69G	SLC38A2_ENST00000547252.1_5'UTR	NM_018976.4	NP_061849.2	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	69	Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	18	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		AGGAAGTAGTACCTGGATGCT	0.378000													8	128					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68419112	68419112	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:68419112T>C	ENST00000297770.4	-	6	761	c.546A>G	c.(544-546)cgA>cgG	p.R182R	CPA6_ENST00000518549.1_Silent_p.R182R|CPA6_ENST00000297769.4_Silent_p.R34R	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	182					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TGAGTCGTGATCGTCTGCCCA	0.393000													4	63					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155023290	155023290	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:155023290G>A	ENST00000295542.1	+	17	2163	c.2067G>A	c.(2065-2067)gaG>gaA	p.E689E	DCST1_ENST00000423025.2_Silent_p.E664E	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	689						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCCGCGAAGAGCTCTCTTCCT	0.642000											OREG0013846	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	27					0	0	1	0	0
RNGTT	8732	broad.mit.edu	37	6	89554217	89554217	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:89554217A>G	ENST00000369485.4	-	11	1314	c.1128T>C	c.(1126-1128)gaT>gaC	p.D376D	RNGTT_ENST00000265607.6_Silent_p.D376D|RNGTT_ENST00000538899.1_Silent_p.D316D|RNGTT_ENST00000369475.3_Silent_p.D376D	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	376	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		GAACATTAAAATCACAATCTC	0.353000													37	83					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145580835	145580835	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:145580835C>T	ENST00000296575.3	+	4	1331	c.676C>T	c.(676-678)Ctg>Ttg	p.L226L	HHIP_ENST00000434550.2_Silent_p.L226L|HHIP_ENST00000511314.1_3'UTR|HHIP-AS1_ENST00000512359.1_RNA	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	226						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TGTGAGTGGGCTGCGGCAGCC	0.463000													5	211					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134131842	134131842	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:134131842T>C	ENST00000452510.2	+	15	2112		c.e15+2		DDX46_ENST00000354283.4_Splice_Site	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46						mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTCATGGAGGTAATTATTCAC	0.353000													5	53					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668030	59668030	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:59668030A>G	ENST00000521764.1	-	1	533	c.512T>C	c.(511-513)gTc>gCc	p.V171A		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	171					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					TGTTTCATCGACCTCTTCCTC	0.448000													8	297					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30198121	30198121	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:30198121T>C	ENST00000397771.2	-	15	1607	c.1430A>G	c.(1429-1431)gAc>gGc	p.D477G	ASCC2_ENST00000542393.1_Missense_Mutation_p.D401G|ASCC2_ENST00000307790.3_Missense_Mutation_p.D477G			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	477	CUE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			TGGCAGCAGGTCCTTCACTTG	0.597000													17	51					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145772613	145772613	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145772613C>T	ENST00000276826.5	-	4	2058	c.1857G>A	c.(1855-1857)agG>agA	p.R619R	ARHGAP39_ENST00000377307.2_Silent_p.R619R|ARHGAP39_ENST00000540274.1_Silent_p.R619R			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	619					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CGAAGGTGCCCCTCCTCCAGT	0.682000													10	37					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22414896	22414896	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:22414896C>T	ENST00000334304.5	-	14	2410	c.2141G>A	c.(2140-2142)gGc>gAc	p.G714D	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	714	GPS.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TGACTTCCAGCCTCCTTGTCC	0.468000													42	169					0	0	1	0	0
RIC3	79608	broad.mit.edu	37	11	8161645	8161645	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:8161645C>T	ENST00000343202.4	-	2	285	c.220G>A	c.(220-222)Gag>Aag	p.E74K	RIC3_ENST00000425599.2_Missense_Mutation_p.E74K|RIC3_ENST00000335425.7_Intron|RIC3_ENST00000309737.6_Missense_Mutation_p.E74K|RIC3_ENST00000539720.1_Missense_Mutation_p.E25K|RIC3_ENST00000419822.2_Missense_Mutation_p.E74K	NM_001206671.2|NM_024557.4	NP_001193600.1|NP_078833.3	Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	74						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		GCAAATGCCTCGGCAAGGTGA	0.537000													27	98					0	0	1	0	0
VPS26A	9559	broad.mit.edu	37	10	70922189	70922189	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:70922189A>G	ENST00000373382.1	+	7	1232	c.579A>G	c.(577-579)ggA>ggG	p.G193G	VPS26A_ENST00000263559.6_Silent_p.G193G|VPS26A_ENST00000395098.1_Silent_p.G193G|VPS26A_ENST00000490696.1_3'UTR|VPS26A_ENST00000546041.1_Silent_p.G176G|VPS26A_ENST00000541711.1_Silent_p.G82G|VPS26A_ENST00000489794.1_Silent_p.G168G			O75436	VP26A_HUMAN	vacuolar protein sorting 26 homolog A (S. pombe)	193					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)	8						TGATTGTTGGAAAAATTTACT	0.294000													9	28					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946358	16946358	+	RNA	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16946358G>A	ENST00000412962.1	-	0	1161																											TCTCGCTCTCGGCCAGGAGGA	0.662000													4	17					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112608228	112608228	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112608228G>A	ENST00000550722.1	-	69	11918	c.11523C>T	c.(11521-11523)acC>acT	p.T3841T	HECTD4_ENST00000430131.2_Silent_p.T3565T|HECTD4_ENST00000377560.5_Silent_p.T3815T	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GATTCATCACGGTCACCTTCG	0.582000											OREG0022132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	45					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92441051	92441051	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:92441051T>C	ENST00000267622.4	-	19	5867	c.5494A>G	c.(5494-5496)Atg>Gtg	p.M1832V		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1832					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CACCCAGTCATCCACCTGGTA	0.368000			T	PDGFRB	AML								12	22					0	0	1	0	0
RBMS1	5937	broad.mit.edu	37	2	161159980	161159980	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:161159980T>C	ENST00000348849.3	-	5	851	c.421A>G	c.(421-423)Acc>Gcc	p.T141A	RBMS1_ENST00000409289.2_Missense_Mutation_p.T108A|RBMS1_ENST00000409075.1_Missense_Mutation_p.T108A|RBMS1_ENST00000392753.3_Missense_Mutation_p.T141A|RBMS1_ENST00000474820.1_5'UTR|RBMS1_ENST00000409972.1_Missense_Mutation_p.T108A	NM_002897.4|NM_016836.3	NP_002888.1|NP_058520.1	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting protein 1	141	RRM 2.				DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding		PLA2R1/RBMS1(2)								TAGAGGTTGGTAGGATCTTGT	0.358000													25	95					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836112	12836112	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:12836112C>A	ENST00000357726.4	+	2	741	c.714C>A	c.(712-714)ttC>ttA	p.F238L		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	238										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGTTCTCTTCAACATCCATG	0.517000													36	132					4.65686e-17	4.89676e-17	1	1	0
PLEC	5339	broad.mit.edu	37	8	145024806	145024806	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145024806G>A	ENST00000322810.4	-	1	238	c.69C>T	c.(67-69)ggC>ggT	p.G23G	PLEC_ENST00000527096.1_Intron|PLEC_ENST00000356346.3_Intron|PLEC_ENST00000436759.2_Intron|PLEC_ENST00000354958.2_Intron	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	23	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCACCATCACGCCCTCGCGGA	0.701000													6	16					0	0	1	0	0
ATP6AP1	537	broad.mit.edu	37	X	153662660	153662660	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153662660C>T	ENST00000369762.2	+	7	852	c.791C>T	c.(790-792)gCt>gTt	p.A264V		NM_001183.4	NP_001174.2	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1	264					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(5)	14	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AATGACACCGCTCCCCGGATC	0.577000													30	113					0	0	1	0	0
ISOC1	51015	broad.mit.edu	37	5	128440948	128440948	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:128440948C>T	ENST00000173527.5	+	3	516	c.500C>T	c.(499-501)aCg>aTg	p.T167M		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	167						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		CTTGGGAGCACGGTTCAAGAA	0.388000													17	55					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	171956897	171956897	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:171956897A>G	ENST00000358155.4	+	3	513	c.337A>G	c.(337-339)Aaa>Gaa	p.K113E	DNM3_ENST00000520906.1_Missense_Mutation_p.K113E|DNM3_ENST00000367733.2_Missense_Mutation_p.K113E|DNM3_ENST00000355305.5_Missense_Mutation_p.K113E|DNM3_ENST00000367731.1_Missense_Mutation_p.K113E	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	113					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TGGAATGAATAAAGGCATTTC	0.353000													6	188					0	0	1	0	0
SUDS3	64426	broad.mit.edu	37	12	118841279	118841279	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:118841279G>A	ENST00000543473.1	+	10	1072	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	SUDS3_ENST00000541280.1_3'UTR|SUDS3_ENST00000397564.2_Missense_Mutation_p.E255K	NM_022491.2	NP_071936.2	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3 homolog (S. cerevisiae)	254					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding			breast(1)|lung(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAGAGGTTCGAAGCTCGGAT	0.463000													4	31					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975760	44975760	+	Missense_Mutation	SNP	T	T	C	rs34582231	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:44975760T>C	ENST00000340446.4	-	1	722	c.431A>G	c.(430-432)aAc>aGc	p.N144S		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	144						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AGGGGGGATGTTCATCATGGT	0.413000													18	243					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154223759	154223759	+	Nonsense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:154223759A>T	ENST00000428931.1	+	13	1623	c.1456A>T	c.(1456-1458)Aaa>Taa	p.K486*	UBAP2L_ENST00000271877.7_Nonsense_Mutation_p.K497*|UBAP2L_ENST00000361546.2_Nonsense_Mutation_p.K486*|UBAP2L_ENST00000343815.6_Nonsense_Mutation_p.K486*	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	486					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCAGAAACTGAAACAGCAGAA	0.473000													27	96					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586438	20586438	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20586438G>A	ENST00000315543.4	+	1	873	c.873G>A	c.(871-873)tgG>tgA	p.W291*		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TCTACATTTGGCCCTTCGGCA	0.423000													18	68					0	0	1	0	0
B3GNT8	374907	broad.mit.edu	37	19	41931841	41931841	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:41931841C>A	ENST00000321702.2	-	3	1296	c.843G>T	c.(841-843)atG>atT	p.M281I	CTC-435M10.6_ENST00000598887.1_RNA	NM_198540.2	NP_940942.1	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	281					poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity			cervix(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)	11						TCCGGAGAGGCATGGCCTGGG	0.642000													15	52					1.3612e-06	1.39554e-06	1	1	0
OR13D1	286365	broad.mit.edu	37	9	107457096	107457096	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:107457096C>T	ENST00000318763.5	+	1	437	c.394C>T	c.(394-396)Cag>Tag	p.Q132*		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	132					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						CTGTGCTCTGCAGATGGTTGT	0.483000													8	254					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48369218	48369218	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:48369218A>G	ENST00000380518.3	-	51	3932	c.3768T>C	c.(3766-3768)gaT>gaC	p.D1256D	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Silent_p.D1187D	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1256	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TGAGTGTGGCATCCACCTCGG	0.642000													10	128					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33021956	33021956	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:33021956T>C	ENST00000340811.4	-	4	1183	c.1075A>G	c.(1075-1077)Atg>Gtg	p.M359V	PKP2_ENST00000070846.6_Missense_Mutation_p.M359V	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	359					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GCCTCGAGCATACTCACTGCT	0.527000													4	188					0	0	1	0	0
SLC35B2	347734	broad.mit.edu	37	6	44224080	44224080	+	Splice_Site	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:44224080T>A	ENST00000393812.3	-	3	502	c.360_splice	c.e3+1	p.Q120_splice	SLC35B2_ENST00000495706.1_5'UTR|SLC35B2_ENST00000538577.1_Intron|SLC35B2_ENST00000537814.1_Intron|SLC35B2_ENST00000393810.1_Intron	NM_178148.2	NP_835361.1	Q8TB61	S35B2_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2	120					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	15	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCTACCCACCTGGAGCCCTGT	0.617000													23	210					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52825376	52825376	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52825376A>G	ENST00000252245.5	-	4	1041	c.821T>C	c.(820-822)gTc>gCc	p.V274A		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	274	Coil 1B.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CAGAGATTTGACCTTGGCTTC	0.498000													28	118					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126059447	126059447	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:126059447A>G	ENST00000318410.7	-	20	2854		c.e20+1		KIAA0196_ENST00000517845.1_Splice_Site	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196						cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGGTACACCTACTTTGGGTCT	0.517000													17	75					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29820065	29820065	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:29820065A>G	ENST00000569978.1	+	2	376	c.85A>G	c.(85-87)Aca>Gca	p.T29A	MAZ_ENST00000322945.6_Intron|MAZ_ENST00000563402.1_Intron|AC009133.14_ENST00000569981.1_RNA|MAZ_ENST00000568282.1_Intron|MAZ_ENST00000566906.2_Intron|MAZ_ENST00000568544.1_Intron|MAZ_ENST00000219782.6_Intron|MAZ_ENST00000562337.1_Intron|AC009133.14_ENST00000563806.1_RNA|MAZ_ENST00000545521.1_Intron			P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	428					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						CAACAAAGGTACATGCCGAGG	0.607000													5	29					0	0	1	0	0
FBXL8	55336	broad.mit.edu	37	16	67197515	67197515	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67197515T>C	ENST00000258200.3	+	3	1094	c.917T>C	c.(916-918)cTc>cCc	p.L306P	HSF4_ENST00000264009.8_5'UTR|RP11-5A19.5_ENST00000580114.1_Silent_p.A76A|HSF4_ENST00000421453.1_5'UTR|FBXL8_ENST00000519917.1_Missense_Mutation_p.L306P			Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	306							protein binding			endometrium(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		CTGTGCGCGCTCGAGGTGCGC	0.721000													8	15					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245851965	245851965	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:245851965G>A	ENST00000366518.4	+	9	4641	c.4537G>A	c.(4537-4539)Ggc>Agc	p.G1513S	KIF26B_ENST00000407071.2_Missense_Mutation_p.G1894S			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1894					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CCACAGCGGCGGCAGCAGCGG	0.721000													3	23					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129905653	129905653	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:129905653G>A	ENST00000368654.3	-	13	4826	c.4451C>T	c.(4450-4452)aCg>aTg	p.T1484M	MKI67_ENST00000368653.3_Missense_Mutation_p.T1124M	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1484	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTCGTGAGTCGTGGGCTTGTC	0.507000													109	351					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44488161	44488161	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:44488161G>A	ENST00000425708.2	-	7	3343	c.3002C>T	c.(3001-3003)aCt>aTt	p.T1001I	ZNF445_ENST00000396077.2_Missense_Mutation_p.T1001I			P59923	ZN445_HUMAN	zinc finger protein 445	1001					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CCTCTCTCGAGTATGAAATCT	0.443000													5	182					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566157	136566157	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:136566157G>A	ENST00000264162.2	-	8	3770	c.3760C>T	c.(3760-3762)Cga>Tga	p.R1254*		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1254	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCAGCCTTCGCGTCCCCCAG	0.572000													33	116					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88472781	88472781	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:88472781T>C	ENST00000324166.5	+	1	1803	c.112T>C	c.(112-114)Ttg>Ctg	p.L38L	THNSL2_ENST00000358591.2_Silent_p.L38L|THNSL2_ENST00000402102.1_Silent_p.L38L|THNSL2_ENST00000377254.3_Silent_p.L38L|THNSL2_ENST00000449349.1_Silent_p.L6L|THNSL2_ENST00000343544.4_Silent_p.L38L	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	38					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						GCTCCCACAGTTGGACAGAGG	0.597000													29	73					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16465396	16465396	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:16465396C>T	ENST00000308683.2	-	1	505	c.379G>A	c.(379-381)Gcc>Acc	p.A127T		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	127						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GCGTTCATGGCATCCTTGTCC	0.587000													33	110					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62290595	62290595	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:62290595A>G	ENST00000378024.4	-	5	11568	c.11294T>C	c.(11293-11295)gTt>gCt	p.V3765A	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3765					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGGCAGAGAAACATCCACATC	0.468000													8	281					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3169916	3169916	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3169916C>T	ENST00000382192.3	+	7	1460	c.1255C>T	c.(1255-1257)Ccg>Tcg	p.P419S	ZNF205_ENST00000219091.4_Missense_Mutation_p.P419S|RP11-473M20.14_ENST00000575139.1_RNA|RP11-473M20.14_ENST00000576490.1_RNA	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						GGGCGCCAAGCCGCACAAGTG	0.682000													34	129					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19744755	19744755	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19744755G>T	ENST00000203556.4	-	19	2466	c.2329C>A	c.(2329-2331)Cct>Act	p.P777T	GMIP_ENST00000445806.2_Missense_Mutation_p.P748T|GMIP_ENST00000587238.1_Missense_Mutation_p.P751T	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	777	Pro-rich.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						aggggcccaggggctgggctg	0.672000													9	18					3.86212e-05	3.93362e-05	1	1	0
CSPP1	79848	broad.mit.edu	37	8	68089926	68089926	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:68089926G>A	ENST00000262210.5	+	25	3137	c.3106G>A	c.(3106-3108)Gcc>Acc	p.A1036T	CSPP1_ENST00000412460.1_Missense_Mutation_p.A691T|CSPP1_ENST00000521168.1_3'UTR|ARFGEF1_ENST00000520381.1_Intron	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	1071						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TGACTTAGATGCCATCCCAAG	0.313000													24	112					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9582061	9582061	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:9582061G>A	ENST00000460593.1	+	9	2078	c.940G>A	c.(940-942)Ggt>Agt	p.G314S	CPSF3_ENST00000238112.3_Missense_Mutation_p.G351S			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	351					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TAAGAGGAATGGTGTCATTAT	0.453000													63	153					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1537432	1537432	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:1537432C>T	ENST00000447419.2	-	2	706	c.681G>A	c.(679-681)tcG>tcA	p.S227S	PTX4_ENST00000440447.2_Intron|PTX4_ENST00000293922.1_Silent_p.S222S			Q96A99	PTX4_HUMAN	pentraxin 4, long	227						extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GGAGAGGGGCCGAGGAGTCCT	0.692000													16	39					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38816315	38816315	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:38816315A>G	ENST00000310301.4	-	11	900	c.846T>C	c.(844-846)gtT>gtC	p.V282V	VPS41_ENST00000395969.2_Silent_p.V257V|VPS41_ENST00000466017.1_5'UTR	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	282					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						ACGAAAGTACAACAAGCTGAT	0.413000													13	35					0	0	1	0	0
HOXD12	3238	broad.mit.edu	37	2	176964654	176964654	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:176964654T>C	ENST00000406506.2	+	1	197	c.125T>C	c.(124-126)aTc>aCc	p.I42T	HOXD12_ENST00000404162.2_Missense_Mutation_p.I42T			P35452	HXD12_HUMAN	homeobox D12	42				GGQLAALPPISYPRG -> AASLAFPLSPTRA (in Ref. 1; AAF79044).		nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(7)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CTTCCCCCTATCTCCTACCCG	0.711000													10	92					0	0	1	0	0
VPS37D	155382	broad.mit.edu	37	7	73085543	73085543	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:73085543T>C	ENST00000324941.4	+	4	727	c.593T>C	c.(592-594)gTc>gCc	p.V198A	VPS37D_ENST00000451519.1_Missense_Mutation_p.V113A	NM_001077621.1	NP_001071089.1	Q86XT2	VP37D_HUMAN	vacuolar protein sorting 37 homolog D (S. cerevisiae)	198					cellular membrane organization|endosome transport|protein transport	late endosome membrane				central_nervous_system(1)|ovary(1)	2		Lung NSC(55;0.0908)|all_lung(88;0.198)				GCTGCAGCTGTCCTGCCCACT	0.741000													3	18					0	0	1	0	0
HRH2	3274	broad.mit.edu	37	5	175110408	175110408	+	Missense_Mutation	SNP	G	G	A	rs145250724		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:175110408G>A	ENST00000231683.2	+	1	1945	c.172G>A	c.(172-174)Gtg>Atg	p.V58M	HRH2_ENST00000377291.2_Missense_Mutation_p.V58M	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	58					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	TTGTTTCATCGTGTCCTTGGC	0.587000													39	112					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100732416	100732416	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100732416C>T	ENST00000306085.6	+	3	2120	c.1823C>T	c.(1822-1824)gCg>gTg	p.A608V		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	608					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCGTGGCGGGCCACGTG	0.701000													56	132					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128060	147128060	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:147128060A>G	ENST00000282928.4	+	1	890	c.161A>G	c.(160-162)cAc>cGc	p.H54R		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	54					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CCCAGTTCGCACGAGCTGGCT	0.721000													26	62					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95507106	95507106	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:95507106T>C	ENST00000297591.5	-	20	4698	c.4623A>G	c.(4621-4623)atA>atG	p.I1541M	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1541					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GATCTGTATCTATCTCTTCAG	0.323000													61	305					0	0	1	0	0
OXR1	55074	broad.mit.edu	37	8	107719358	107719358	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:107719358G>A	ENST00000445937.1	+	9	1870	c.1609G>A	c.(1609-1611)Gat>Aat	p.D537N	OXR1_ENST00000442977.2_Missense_Mutation_p.D538N|OXR1_ENST00000452423.2_Missense_Mutation_p.D27N|OXR1_ENST00000531443.1_Missense_Mutation_p.D537N|OXR1_ENST00000312046.6_Missense_Mutation_p.D530N|OXR1_ENST00000497705.1_Missense_Mutation_p.D470N|OXR1_ENST00000517566.2_Missense_Mutation_p.D537N	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	538					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TACATCTGCTGATGGACACAT	0.368000													11	71					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3627784	3627784	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:3627784T>C	ENST00000325418.4	+	1	574	c.555T>C	c.(553-555)agT>agC	p.S185S	ITGAE_ENST00000571185.1_5'UTR|ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	185					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										CAAGGGACAGTGTCATCTCGA	0.682000													6	96					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47848441	47848441	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:47848441C>T	ENST00000359568.5	+	35	7734	c.7627C>T	c.(7627-7629)Cgc>Tgc	p.R2543C	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2543					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding	p.R2543C(1)		NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GCAGCACTTGCGCACGGCGCT	0.692000													8	18					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62848555	62848555	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62848555T>C	ENST00000536311.1	+	11	2131	c.1767T>C	c.(1765-1767)agT>agC	p.S589S	MYT1_ENST00000328439.1_Silent_p.S589S|MYT1_ENST00000360149.4_Silent_p.S291S			Q01538	MYT1_HUMAN	myelin transcription factor 1	589					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ACTACGCAAGTTTCGATGCTC	0.532000													7	129					0	0	1	0	0
EFCAB4A	283229	broad.mit.edu	37	11	828642	828642	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:828642C>T	ENST00000450448.1	+	2	540	c.35C>T	c.(34-36)gCc>gTc	p.A12V	EFCAB4A_ENST00000528542.2_Missense_Mutation_p.A12V|EFCAB4A_ENST00000525077.1_Missense_Mutation_p.A12V|AP006621.8_ENST00000532946.1_RNA	NM_173584.3	NP_775855.3	Q8N4Y2	EFC4A_HUMAN	EF-hand calcium binding domain 4A	12					store-operated calcium entry		calcium ion binding			endometrium(1)|large_intestine(1)|lung(1)	3		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGATGAGGCCCAGGAGGAG	0.632000													14	46					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123485615	123485615	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:123485615G>A	ENST00000280562.5	-	8	1344	c.1139C>T	c.(1138-1140)cCg>cTg	p.P380L	PITPNM2_ENST00000320201.4_Missense_Mutation_p.P380L|PITPNM2_ENST00000546049.1_Missense_Mutation_p.P418L|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Missense_Mutation_p.P380L|PITPNM2_ENST00000392428.1_Missense_Mutation_p.P101L			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	380					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGTGTCTTCCGGCTCTGGGCT	0.592000													4	88					0	0	1	0	0
PGM2	55276	broad.mit.edu	37	4	37841857	37841857	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:37841857A>G	ENST00000381967.4	+	6	795	c.695A>G	c.(694-696)gAc>gGc	p.D232G	PGM2_ENST00000537241.1_Missense_Mutation_p.D72G|PGM2_ENST00000544359.1_Missense_Mutation_p.D93G	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	232					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						TACTTTGAAGACCTTAAAAAG	0.383000													24	75					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108593750	108593750	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:108593750G>A	ENST00000526794.1	+	13	1558	c.1526G>A	c.(1525-1527)cGc>cAc	p.R509H	DDX10_ENST00000322536.3_Missense_Mutation_p.R509H			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	509							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GTGGCACCACGCGTAAGATTT	0.423000			T	NUP98	AML*								13	38					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451630	55451630	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55451630G>A	ENST00000588756.1	-	6	1043	c.557C>T	c.(556-558)aCg>aTg	p.T186M	NLRP7_ENST00000328092.5_Missense_Mutation_p.T186M|NLRP7_ENST00000592784.1_Missense_Mutation_p.T186M|NLRP7_ENST00000590030.1_Missense_Mutation_p.T186M|NLRP7_ENST00000340844.2_Missense_Mutation_p.T186M|NLRP7_ENST00000448121.2_Missense_Mutation_p.T186M|NLRP7_ENST00000446217.1_Missense_Mutation_p.T214M			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	186	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTTGGCCAGCGTGGTTTTCCC	0.572000													34	125					0	0	1	0	0
ZDHHC6	64429	broad.mit.edu	37	10	114192220	114192220	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:114192220G>T	ENST00000369405.3	-	9	1428	c.1005C>A	c.(1003-1005)atC>atA	p.I335I	ZDHHC6_ENST00000369404.3_Silent_p.I331I|ZDHHC6_ENST00000482410.1_5'UTR	NM_022494.1	NP_071939.1	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	335						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		AGAAGGTTTTGATTCCTTTAT	0.413000													29	100					9.39395e-14	9.81155e-14	1	1	0
ZNF331	55422	broad.mit.edu	37	19	54081079	54081079	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54081079A>T	ENST00000253144.9	+	7	2598	c.1265A>T	c.(1264-1266)cAc>cTc	p.H422L	ZNF331_ENST00000513999.1_Missense_Mutation_p.H422L|ZNF331_ENST00000511593.2_Missense_Mutation_p.H422L|ZNF331_ENST00000512387.1_Missense_Mutation_p.H422L|ZNF331_ENST00000511154.1_Missense_Mutation_p.H422L|ZNF331_ENST00000449416.1_Missense_Mutation_p.H422L|ZNF331_ENST00000411977.2_Missense_Mutation_p.H422L	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		AGCTTTAGTCACGGCCATCAG	0.488000			T	?	follicular thyroid adenoma								21	46					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39815160	39815160	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:39815160T>C	ENST00000553728.1	+	25	3702	c.3489T>C	c.(3487-3489)tgT>tgC	p.C1163C	CTAGE5_ENST00000557038.1_Silent_p.C548C|CTAGE5_ENST00000396158.2_Silent_p.C633C|CTAGE5_ENST00000348007.3_Silent_p.C585C|CTAGE5_ENST00000341749.3_Silent_p.C616C|CTAGE5_ENST00000553352.1_Silent_p.C599C|CTAGE5_ENST00000396165.4_Silent_p.C599C|CTAGE5_ENST00000341502.5_Silent_p.C628C|CTAGE5_ENST00000280083.3_Silent_p.C628C|RP11-407N17.3_ENST00000603904.1_Silent_p.C599C|CTAGE5_ENST00000556148.1_Silent_p.C553C																							ACAGATTTTGTTCTAATTCTG	0.333000													8	95					0	0	1	0	0
WHAMMP3	339005	broad.mit.edu	37	15	23205102	23205102	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:23205102T>C	ENST00000400153.2	-	0	752					NR_003521.1																						AAGAACGTGGTTGCCACGGTA	0.378000													4	17					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93691984	93691984	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:93691984A>C	ENST00000343253.7	+	17	2769	c.2267A>C	c.(2266-2268)cAg>cCg	p.Q756P	CCDC18_ENST00000401026.3_Missense_Mutation_p.Q757P|CCDC18_ENST00000334652.5_Missense_Mutation_p.Q52P|CCDC18_ENST00000338949.4_Missense_Mutation_p.Q512P|CCDC18_ENST00000557479.1_Missense_Mutation_p.Q875P|CCDC18_ENST00000421014.2_3'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	756										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TTTGAAAAACAGTTAAAGAAG	0.289000													12	34					0	0	1	0	0
DLAT	1737	broad.mit.edu	37	11	111899652	111899652	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:111899652T>C	ENST00000280346.6	+	4	1302	c.643T>C	c.(643-645)Tat>Cat	p.Y215H	DLAT_ENST00000537636.1_Intron|DLAT_ENST00000393051.1_Missense_Mutation_p.Y215H	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	215					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	TGGTAGCTCATATCCCCCTCA	0.527000													27	95					0	0	1	0	0
SETDB2	83852	broad.mit.edu	37	13	50035241	50035241	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:50035241C>T	ENST00000354234.4	+	4	1057	c.151C>T	c.(151-153)Caa>Taa	p.Q51*	SETDB2_ENST00000317257.8_Nonsense_Mutation_p.Q51*|SETDB2_ENST00000258672.5_Nonsense_Mutation_p.Q51*	NM_001160308.1	NP_001153780.1	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2	51					cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	15		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		AGAATACATCCAAGCAATGAT	0.313000													29	104					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233392148	233392148	+	Missense_Mutation	SNP	T	T	C	rs121909509		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233392148T>C	ENST00000258385.3	+	3	268	c.236T>C	c.(235-237)aTa>aCa	p.I79T	CHRND_ENST00000536614.1_Missense_Mutation_p.I79T|CHRND_ENST00000457943.2_5'UTR|CHRND_ENST00000543200.1_Intron	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	79					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		AATGTGTGGATAGAGCACGTA	0.537000													32	89					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15496799	15496799	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:15496799A>G	ENST00000341776.2	+	7	1587	c.1343A>G	c.(1342-1344)cAc>cGc	p.H448R	JARID2_ENST00000541660.1_Missense_Mutation_p.H410R|JARID2_ENST00000397311.3_Missense_Mutation_p.H276R	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	448					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GAAGAGGCACACCAGGCGGAG	0.687000													11	27					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25271252	25271252	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:25271252G>A	ENST00000216962.4	+	16	2073	c.1963G>A	c.(1963-1965)Gag>Aag	p.E655K		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	655					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GTCCTTGGCTGAGAAAGGTAA	0.557000													37	166					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25376682	25376682	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:25376682A>T	ENST00000255324.5	+	14	1974	c.1922A>T	c.(1921-1923)gAt>gTt	p.D641V	RNF17_ENST00000381921.1_Missense_Mutation_p.D641V|RNF17_ENST00000255325.5_Missense_Mutation_p.D642V	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	641					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCTCTTAGAGATGCGCTAGTT	0.323000													10	97					0	0	1	0	0
ATAD3A	55210	broad.mit.edu	37	1	1458248	1458248	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1458248C>T	ENST00000378755.5	+	8	1113	c.1019C>T	c.(1018-1020)aCg>aTg	p.T340M	ATAD3A_ENST00000378756.3_Missense_Mutation_p.T292M|ATAD3A_ENST00000536055.1_Missense_Mutation_p.T213M	NM_018188.3	NP_060658.3	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	340							ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(4)|kidney(6)|large_intestine(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		TCCCGCATCACGGTGCTTGAG	0.662000													14	39					0	0	1	0	0
ZNF175	7728	broad.mit.edu	37	19	52076596	52076596	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:52076596T>C	ENST00000262259.2	+	2	372	c.14T>C	c.(13-15)gTg>gCg	p.V5A	ZNF175_ENST00000545217.1_Missense_Mutation_p.V5A|ZNF175_ENST00000596504.1_Missense_Mutation_p.V5A|ZNF175_ENST00000436511.2_Missense_Mutation_p.V5A	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	5					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		CCTGCTGATGTGAATTTATCC	0.527000													5	188					0	0	1	0	0
UPF2	26019	broad.mit.edu	37	10	11998356	11998356	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:11998356A>G	ENST00000356352.2	-	12	3010	c.2537T>C	c.(2536-2538)gTg>gCg	p.V846A	UPF2_ENST00000397053.2_Missense_Mutation_p.V846A|UPF2_ENST00000357604.5_Missense_Mutation_p.V846A			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	846	Binds to UPF3B.|MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.|Sufficient for interaction with UPF3A and UPF3B.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				CACTCCATCCACAACGTGGAT	0.378000													26	86					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43575936	43575936	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:43575936T>C	ENST00000406487.1	-	4	978	c.880A>G	c.(880-882)Aag>Gag	p.K294E		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	294	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				CCGCTATGCTTTGTAGTAATT	0.468000													9	403					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31803104	31803104	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:31803104C>T	ENST00000261592.5	-	1	411	c.114G>A	c.(112-114)caG>caA	p.Q38Q	RP11-379L18.1_ENST00000587528.1_RNA|NOL4_ENST00000589544.1_Silent_p.Q38Q|NOL4_ENST00000269185.4_5'UTR	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	38						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CATTGAGGAGCTGGACGATCC	0.577000													30	87					0	0	1	0	0
NRTN	4902	broad.mit.edu	37	19	5824275	5824275	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:5824275C>T	ENST00000303212.2	+	1	463	c.99C>T	c.(97-99)ctC>ctT	p.L33L		NM_004558.3	NP_004549.1	Q99748	NRTN_HUMAN	neurturin	33					axon guidance|MAPKKK cascade|neural crest cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region	growth factor activity	p.L33L(1)		large_intestine(1)	1						GCCACCGCCTCGGACCTGCGC	0.672000													6	17					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409225	56409225	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:56409225C>T	ENST00000544374.1	-	1	722	c.694G>A	c.(694-696)Gtc>Atc	p.V232I	OR5AP2_ENST00000302981.1_Missense_Mutation_p.V231I			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						ATCTTCAAGACGGCAATGAAG	0.443000													45	143					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927642	92927642	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:92927642T>C	ENST00000373079.3	-	1	925	c.662A>G	c.(661-663)aAg>aGg	p.K221R	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	221	Glu-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						AGGAACTTCCTTTTCTTCATC	0.398000													13	56					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101757406	101757406	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:101757406A>G	ENST00000261637.4	+	45	6017	c.5843A>G	c.(5842-5844)cAg>cGg	p.Q1948R		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1948					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GAAGTAAAGCAGATCCTCTCC	0.388000													19	62					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37879903	37879903	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:37879903A>G	ENST00000436120.2	+	5	1059	c.952A>G	c.(952-954)Agt>Ggt	p.S318G	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTCTTTCTCAGTGAACATCA	0.403000													26	129					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55914784	55914784	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:55914784A>G	ENST00000447944.2	-	2	304	c.218T>C	c.(217-219)gTa>gCa	p.V73A		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	73					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TTTTACCTGTACTACAGCAGA	0.323000													14	75					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19861847	19861847	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:19861847T>C	ENST00000225737.6	-	4	514	c.357A>G	c.(355-357)aaA>aaG	p.K119K	AKAP10_ENST00000572155.1_5'UTR|AKAP10_ENST00000395536.3_Silent_p.K119K	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	119					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					AAAGGCTTGATTTGGTCTCTT	0.403000													20	60					0	0	1	0	0
MARK3	4140	broad.mit.edu	37	14	103923477	103923477	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:103923477A>G	ENST00000429436.2	+	6	922		c.e6-1		MARK3_ENST00000561071.1_Intron|MARK3_ENST00000440884.3_Splice_Site|MARK3_ENST00000416682.2_Splice_Site|MARK3_ENST00000335102.5_Splice_Site|MARK3_ENST00000303622.9_Splice_Site|MARK3_ENST00000216288.7_Splice_Site|MARK3_ENST00000553942.1_Splice_Site	NM_001128918.1|NM_001128919.1	NP_001122390.1|NP_001122391.1	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3								ATP binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30		Melanoma(154;0.155)	Epithelial(46;0.241)			TCTCACCTATAGGTGAAGTAT	0.303000													21	42					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482920	20482920	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:20482920A>G	ENST00000573854.1	+	6	917	c.803A>G	c.(802-804)aAc>aGc	p.N268S	ACSM2A_ENST00000536134.1_Missense_Mutation_p.N40S|ACSM2A_ENST00000219054.6_Missense_Mutation_p.N268S|ACSM2A_ENST00000417235.2_Missense_Mutation_p.N189S|ACSM2A_ENST00000575690.1_Missense_Mutation_p.N268S|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000396104.2_Missense_Mutation_p.N268S	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	268					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TGGATACTGAACATCTTGTGC	0.433000													48	192					0	0	1	0	0
JAM2	58494	broad.mit.edu	37	21	27086964	27086964	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:27086964A>G	ENST00000480456.1	+	10	1427	c.877A>G	c.(877-879)Aca>Gca	p.T293A	JAM2_ENST00000477351.1_3'UTR|JAM2_ENST00000312957.5_Missense_Mutation_p.T293A|JAM2_ENST00000425221.2_Missense_Mutation_p.T257A	NM_001270407.1|NM_021219.3	NP_001257336.1|NP_067042.1	P57087	JAM2_HUMAN	junctional adhesion molecule 2	293				DFKHTKSFII -> VQWLTPVIPALWKAAAGGSRGQEF (in Ref. 4; AAQ88727).	blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|urinary_tract(1)	19						TTTCAAGCACACAAAATCCTT	0.279000													22	49					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34900476	34900476	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:34900476T>C	ENST00000381831.3	-	10	1326	c.1063A>G	c.(1063-1065)Aca>Gca	p.T355A	GART_ENST00000381815.4_Missense_Mutation_p.T355A|GART_ENST00000381839.3_Missense_Mutation_p.T355A|GART_ENST00000361093.5_Missense_Mutation_p.T355A	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	355					'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	CACTCACCTGTTATCTCTACA	0.512000													5	146					0	0	1	0	0
TRA2B	6434	broad.mit.edu	37	3	185636151	185636151	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:185636151A>G	ENST00000453386.2	-	8	1132		c.e8+1		TRA2B_ENST00000382191.4_Splice_Site	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)						nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						ATAAAAACTTACGAGGTGAGT	0.373000													22	71					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14940263	14940263	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:14940263A>G	ENST00000261167.2	-	12	1895	c.1662T>C	c.(1660-1662)atT>atC	p.I554I	WBP11_ENST00000537574.1_Silent_p.I520I	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	554					mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						CTTTCTTCTCAATGGTGGCTG	0.542000													26	996					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38462567	38462567	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:38462567T>C	ENST00000399017.2	+	6	3208	c.461T>C	c.(460-462)aTt>aCt	p.I154T	TTC3_ENST00000354749.2_Missense_Mutation_p.I154T|TTC3_ENST00000355666.1_Missense_Mutation_p.I154T|TTC3_ENST00000540756.1_Intron|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000399010.1_Missense_Mutation_p.I154T	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	154					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TTATTGAGAATTGGTTGTAAA	0.358000													15	34					0	0	1	0	0
NEMF	9147	broad.mit.edu	37	14	50295332	50295332	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:50295332A>G	ENST00000298310.5	-	14	1874		c.e14+1		NEMF_ENST00000556925.1_Splice_Site|NEMF_ENST00000546046.1_Splice_Site|NEMF_ENST00000545773.1_Splice_Site			O60524	NEMF_HUMAN	nuclear export mediator factor							cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						TAAATGACTTACTTTTTGGCA	0.313000													32	62					0	0	1	0	0
BRPF1	7862	broad.mit.edu	37	3	9782627	9782627	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:9782627T>C	ENST00000383829.2	+	4	2126		c.e4+2		BRPF1_ENST00000433861.2_Splice_Site|BRPF1_ENST00000424362.1_Splice_Site|BRPF1_ENST00000302054.3_Splice_Site|BRPF1_ENST00000457855.1_Splice_Site	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1						histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					CAAGTTGGGGTACTGTGTCCA	0.537000													8	25					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153039011	153039011	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153039011A>T	ENST00000538966.1	+	20	3462	c.3191A>T	c.(3190-3192)gAc>gTc	p.D1064V	PLXNB3_ENST00000361971.5_Missense_Mutation_p.D1041V|PLXNB3_ENST00000538282.1_Missense_Mutation_p.D651V|PLXNB3_ENST00000538776.1_Missense_Mutation_p.D694V	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1041	IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCGGCCTAGACGTGGTGCAG	0.687000													20	22					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31779499	31779499	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31779499A>T	ENST00000375654.4	-	2	440	c.251T>A	c.(250-252)gTt>gAt	p.V84D	HSPA1L_ENST00000417199.3_Missense_Mutation_p.V84D	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	84					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TGCTTGTACAACAGGATCATT	0.443000													9	173					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31860502	31860502	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:31860502T>A	ENST00000395728.3	-	5	847	c.848A>T	c.(847-849)aAa>aTa	p.K283I	EHMT2_ENST00000375528.4_Missense_Mutation_p.K283I|EHMT2_ENST00000375530.4_Missense_Mutation_p.K226I|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375537.4_Missense_Mutation_p.K226I			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	226					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						CTTCCTCCTTTTGGCCAGATC	0.602000													7	136					0	0	1	0	0
SPIRE2	84501	broad.mit.edu	37	16	89916916	89916916	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:89916916G>A	ENST00000378247.3	+	3	536	c.493G>A	c.(493-495)Gtg>Atg	p.V165M	SPIRE2_ENST00000393062.2_Missense_Mutation_p.V165M|SPIRE2_ENST00000564878.1_3'UTR	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	165	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CCCCCGCAGCGTGCGCACCTT	0.736000													5	7					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141889621	141889621	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:141889621A>G	ENST00000522684.1	-	4	540	c.311T>C	c.(310-312)gTc>gCc	p.V104A	PTK2_ENST00000340930.3_Missense_Mutation_p.V104A|PTK2_ENST00000517887.1_Missense_Mutation_p.V148A|PTK2_ENST00000521059.1_Missense_Mutation_p.V104A|PTK2_ENST00000519881.1_Missense_Mutation_p.V104A|PTK2_ENST00000535192.1_Missense_Mutation_p.V104A|PTK2_ENST00000395218.2_Missense_Mutation_p.V104A|PTK2_ENST00000519419.1_Missense_Mutation_p.V148A|PTK2_ENST00000520892.1_Missense_Mutation_p.V104A	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	104	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CACACTGGAGACGCCCATATC	0.502000													124	372					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145838817	145838817	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:145838817T>C	ENST00000296702.5	+	4	847	c.809T>C	c.(808-810)gTa>gCa	p.V270A	TCERG1_ENST00000394421.2_Missense_Mutation_p.V270A	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	270	Thr-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACCTGCAGTATCCACTTCA	0.557000													4	213					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17822142	17822142	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:17822142A>C	ENST00000325083.8	+	18	3159	c.2720A>C	c.(2719-2721)tAc>tCc	p.Y907S	PCM1_ENST00000519253.1_Missense_Mutation_p.Y907S|PCM1_ENST00000524226.1_Missense_Mutation_p.Y908S	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	907					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		GAAGACGGTTACCTTTCTGAA	0.428000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								5	89					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58090906	58090906	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:58090906C>A	ENST00000357272.4	+	11	1875	c.1710C>A	c.(1708-1710)ttC>ttA	p.F570L	FLNB_ENST00000348383.5_Missense_Mutation_p.F570L|FLNB_ENST00000429972.2_Missense_Mutation_p.F570L|FLNB_ENST00000358537.3_Missense_Mutation_p.F570L|FLNB_ENST00000493452.1_Missense_Mutation_p.F401L|FLNB_ENST00000295956.4_Missense_Mutation_p.F570L|FLNB_ENST00000490882.1_Missense_Mutation_p.F570L|FLNB_ENST00000419752.2_Missense_Mutation_p.F401L			O75369	FLNB_HUMAN	filamin B, beta	570					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CAGCGGACTTCGTGGTAGAAT	0.582000													29	98					6.07407e-21	6.40789e-21	1	1	0
ADSL	158	broad.mit.edu	37	22	40759036	40759036	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:40759036G>A	ENST00000216194.7	+	10	1118	c.1062G>A	c.(1060-1062)acG>acA	p.T354T	ADSL_ENST00000342312.6_Silent_p.T354T|ADSL_ENST00000454266.2_Silent_p.T368T	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	354					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						TATTGAATACGCTGCAGAACA	0.408000													38	132					0	0	1	0	0
FCGR3B	2215	broad.mit.edu	37	1	161600913	161600913	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:161600913A>G	ENST00000531221.1	-	1	83	c.80T>C	c.(79-81)tTg>tCg	p.L27S	FCGR2B_ENST00000367960.5_Intron|FCGR2B_ENST00000367962.4_Intron|FCGR2B_ENST00000428605.2_Intron|FCGR2B_ENST00000403078.3_Intron|FCGR3B_ENST00000367964.2_5'UTR|FCGR3B_ENST00000294800.3_5'UTR|FCGR3A_ENST00000540048.1_5'UTR			O75015	FCG3B_HUMAN	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	18	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACAAGTCACCAAAGATATCCG	0.552000													9	35					0	0	1	0	0
RENBP	5973	broad.mit.edu	37	X	153205600	153205600	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153205600C>T	ENST00000393700.3	-	9	1112	c.1032G>A	c.(1030-1032)gtG>gtA	p.V344V	RENBP_ENST00000412763.1_3'UTR|RENBP_ENST00000369997.3_Silent_p.V330V	NM_002910.5	NP_002901.2	P51606	RENBP_HUMAN	renin binding protein	344					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GGCGCAGCAGCACAGGGTCCC	0.597000													29	31					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47356682	47356682	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47356682C>T	ENST00000399249.2	-	26	2870	c.2816G>A	c.(2815-2817)cGg>cAg	p.R939Q	MYBPC3_ENST00000256993.4_Missense_Mutation_p.R938Q|MYBPC3_ENST00000545968.1_Missense_Mutation_p.R939Q			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	938	Fibronectin type-III 2.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GAAAAGCAGCCGGGCCCCCGT	0.672000													14	44					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48387850	48387850	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:48387850G>A	ENST00000224600.4	-	1	3141	c.3028C>T	c.(3028-3030)Cgc>Tgc	p.R1010C		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1010	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCAGGAATGCGGTCCTTGGCA	0.602000													30	107					0	0	1	0	0
NKIRAS1	28512	broad.mit.edu	37	3	23942526	23942526	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:23942526C>T	ENST00000443659.2	-	3	886	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	NKIRAS1_ENST00000415901.2_Missense_Mutation_p.E37K|NKIRAS1_ENST00000388759.3_Missense_Mutation_p.E37K|NKIRAS1_ENST00000412028.1_Missense_Mutation_p.E37K|NKIRAS1_ENST00000416026.2_Missense_Mutation_p.E37K|NKIRAS1_ENST00000425478.2_Missense_Mutation_p.E37K|NKIRAS1_ENST00000437230.1_Missense_Mutation_p.E37K|NKIRAS1_ENST00000421515.2_Missense_Mutation_p.E37K			Q9NYS0	KBRS1_HUMAN	NFKB inhibitor interacting Ras-like 1	37					I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	7						TCCATTGTTTCGCAATCTTCC	0.398000													43	146					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28848871	28848871	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:28848871G>A	ENST00000357727.2	+	9	1484	c.1094G>A	c.(1093-1095)cGc>cAc	p.R365H	CREB5_ENST00000396298.2_Missense_Mutation_p.R226H|CREB5_ENST00000396300.2_Missense_Mutation_p.R358H|CREB5_ENST00000409603.1_Missense_Mutation_p.R332H|CREB5_ENST00000396299.2_Missense_Mutation_p.R332H	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	365					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						ACAGGGGGGCGCCGGCGAAGG	0.632000													31	92					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101908	168101908	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:168101908A>G	ENST00000409195.1	+	9	4095	c.4006A>G	c.(4006-4008)Aca>Gca	p.T1336A	XIRP2_ENST00000409273.1_Missense_Mutation_p.T1114A|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.T1336A|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1161					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGAAGTGACCACAGTTAAAAA	0.388000													4	81					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212799452	212799452	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:212799452G>A	ENST00000294829.3	+	1	1664	c.1233G>A	c.(1231-1233)gaG>gaA	p.E411E	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	411										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		ATGGAAGGGAGCGAACCCAGG	0.622000													20	72					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362410	105362410	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:105362410C>T	ENST00000369774.4	-	15	2841	c.2565G>A	c.(2563-2565)caG>caA	p.Q855Q	SH3PXD2A_ENST00000540321.1_Silent_p.Q722Q|SH3PXD2A_ENST00000538130.1_Silent_p.Q690Q|SH3PXD2A_ENST00000355946.2_Silent_p.Q827Q|SH3PXD2A_ENST00000427662.2_Intron|SH3PXD2A_ENST00000315994.6_5'UTR			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	855	SH3 4.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TCTCCGAGTCCTGGACCTTCT	0.632000													32	78					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310215	57310215	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:57310215A>G	ENST00000457912.1	+	2	154	c.154A>G	c.(154-156)Acc>Gcc	p.T52A	SMTNL1_ENST00000399154.2_Missense_Mutation_p.T34A|SMTNL1_ENST00000527972.1_Missense_Mutation_p.T34A			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	34										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						TGCAGAGGAGACCAAAGGCAC	0.597000													13	28					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145001740	145001740	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145001740C>A	ENST00000322810.4	-	27	4174	c.4005G>T	c.(4003-4005)cgG>cgT	p.R1335R	PLEC_ENST00000527096.1_Silent_p.R1221R|PLEC_ENST00000356346.3_Silent_p.R1184R|PLEC_ENST00000436759.2_Silent_p.R1225R|PLEC_ENST00000357649.2_Silent_p.R1202R|PLEC_ENST00000354589.3_Silent_p.R1198R|PLEC_ENST00000398774.2_Silent_p.R1166R|PLEC_ENST00000345136.3_Silent_p.R1198R|PLEC_ENST00000354958.2_Silent_p.R1176R	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1335	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCTCGCGCTGCCGCACGTCGG	0.731000													3	26					0.004672	0.00470748	1	1	0
GPRIN2	9721	broad.mit.edu	37	10	46998978	46998978	+	Missense_Mutation	SNP	G	G	A	rs151134434	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:46998978G>A	ENST00000374314.4	+	1	1053	c.98G>A	c.(97-99)cGg>cAg	p.R33Q	GPRIN2_ENST00000374317.1_Missense_Mutation_p.R33Q			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	33										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GGTGAAGGCCGGGAACAGAGG	0.721000													24	84					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111217120	111217120	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:111217120C>T	ENST00000369769.2	-	1	535	c.312G>A	c.(310-312)gaG>gaA	p.E104E		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	104						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGACCACGCGCTCCCCGCAGC	0.726000													17	64					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10411938	10411938	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:10411938T>C	ENST00000226207.5	-	16	1733	c.1639A>G	c.(1639-1641)Aca>Gca	p.T547A	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	547	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GAGGTGTCTGTCGCCTTGGGG	0.463000													4	133					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152318798	152318798	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:152318798A>C	ENST00000243326.4	+	27	3753	c.3270A>C	c.(3268-3270)caA>caC	p.Q1090H	RIF1_ENST00000430328.2_Missense_Mutation_p.Q1090H|RIF1_ENST00000453091.2_Missense_Mutation_p.Q1090H|RIF1_ENST00000444746.2_Missense_Mutation_p.Q1090H|RIF1_ENST00000428287.2_Missense_Mutation_p.Q1090H			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1090					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATGTTTCCCAAGATACCTTAT	0.284000													14	45					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96293612	96293612	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:96293612T>C	ENST00000347108.3	-	3	966	c.534A>G	c.(532-534)aaA>aaG	p.K178K	DZIP1_ENST00000361396.2_Silent_p.K178K|DZIP1_ENST00000466027.1_5'UTR|DZIP1_ENST00000376829.2_Silent_p.K178K|DZIP1_ENST00000361156.3_Silent_p.K178K			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	178					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCTTCCGGCGTTTGCACTCTT	0.577000													5	59					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41058281	41058281	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:41058281C>T	ENST00000399564.4	-	7	1090	c.640G>A	c.(640-642)Ggg>Agg	p.G214R	MROH2B_ENST00000506092.2_5'UTR	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ACCGTGGGCCCGTGGGCCTTA	0.502000													16	35					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108636205	108636205	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:108636205A>G	ENST00000218006.2	-	13	2795	c.2504T>C	c.(2503-2505)tTg>tCg	p.L835S		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	835					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						CAAATCTTCCAAGTTGCTAGA	0.373000													25	104					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52280401	52280401	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:52280401A>G	ENST00000354831.7	-	14	1917	c.1728T>C	c.(1726-1728)atT>atC	p.I576I	NRD1_ENST00000539524.1_Silent_p.I444I|NRD1_ENST00000544028.1_Silent_p.I376I|NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000352171.7_Silent_p.I508I	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	507					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						CAGTCAATGTAATAGAAATGC	0.348000													7	29					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94155029	94155029	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:94155029T>C	ENST00000553484.1	+	46	7265	c.7111T>C	c.(7111-7113)Tcc>Ccc	p.S2371P	UNC79_ENST00000555664.1_Missense_Mutation_p.S2310P|UNC79_ENST00000256339.4_Missense_Mutation_p.S2172P|UNC79_ENST00000393151.2_Missense_Mutation_p.S2349P			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2349						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GAAGACATGTTCCCAGCCTCT	0.483000													8	84					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70253658	70253658	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:70253658C>G	ENST00000346329.3	+	4	430	c.122C>G	c.(121-123)gCc>gGc	p.A41G	CTTN_ENST00000527622.1_3'UTR|CTTN_ENST00000376561.3_Missense_Mutation_p.A41G|CTTN_ENST00000301843.8_Missense_Mutation_p.A41G	NM_138565.2	NP_612632.1	Q14247	SRC8_HUMAN	cortactin	41						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AGATGGGGTGCCAAGACGGTG	0.572000													4	125					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090570	91090570	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:91090570G>A	ENST00000373094.1	+	1	912	c.67G>A	c.(67-69)Gcc>Acc	p.A23T	PCDH11X_ENST00000298274.8_Missense_Mutation_p.A23T|PCDH11X_ENST00000504220.1_Missense_Mutation_p.A23T|PCDH11X_ENST00000406881.1_Missense_Mutation_p.A23T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.A23T|PCDH11X_ENST00000395337.2_Missense_Mutation_p.A23T|PCDH11X_ENST00000373088.1_Missense_Mutation_p.A23T|PCDH11X_ENST00000361724.1_Missense_Mutation_p.A23T|PCDH11X_ENST00000361655.2_Missense_Mutation_p.A23T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	23					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCACTCTGGCGCCCAGGAGAA	0.473000													24	33					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131669814	131669814	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:131669814A>G	ENST00000259324.5	+	3	894	c.371A>G	c.(370-372)tAc>tGc	p.Y124C	LRRC8A_ENST00000372600.4_Missense_Mutation_p.Y124C|LRRC8A_ENST00000372599.3_Missense_Mutation_p.Y124C	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	124					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						TTTGCCAAGTACTTCCCCTAC	0.567000													35	125					0	0	1	0	0
ZNF302	55900	broad.mit.edu	37	19	35175530	35175530	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:35175530T>C	ENST00000505242.1	+	5	1082	c.588T>C	c.(586-588)aaT>aaC	p.N196N	ZNF302_ENST00000505365.2_3'UTR|ZNF302_ENST00000457781.2_Silent_p.N196N|ZNF302_ENST00000446502.2_Silent_p.N240N|ZNF302_ENST00000423823.2_Silent_p.N196N			Q9NR11	ZN302_HUMAN	zinc finger protein 302	275					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AGACTTGTAATAGAGAGAAAA	0.413000													4	227					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12939677	12939677	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:12939677A>G	ENST00000218032.6	+	2	2605	c.2518A>G	c.(2518-2520)Acc>Gcc	p.T840A	TLR8_ENST00000311912.5_Missense_Mutation_p.T858A	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	840					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTTTATCACCACCATGGTTAT	0.403000													7	107					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64458997	64458997	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:64458997G>C	ENST00000355086.3	+	8	1647	c.1123G>C	c.(1123-1125)Gag>Cag	p.E375Q	RP11-196H14.2_ENST00000535594.1_RNA|SRGAP1_ENST00000543397.1_Missense_Mutation_p.E335Q|SRGAP1_ENST00000357825.3_Missense_Mutation_p.E375Q	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	375					axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CGAGAATGAAGAGGTGAGCAT	0.488000													8	17					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107115416	107115416	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:107115416G>A	ENST00000304402.4	+	3	2254	c.911G>A	c.(910-912)cGa>cAa	p.R304Q	COG5_ENST00000475638.2_Intron|COG5_ENST00000347053.3_Intron|COG5_ENST00000393603.2_Intron|COG5_ENST00000297135.3_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	304						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						CACCGTGAACGACGAGAAAGA	0.398000													16	71					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801644	67801644	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:67801644C>T	ENST00000544246.1	-	2	1620	c.929G>A	c.(928-930)gGg>gAg	p.G310E	PCDH9_ENST00000328454.5_Missense_Mutation_p.G310E|PCDH9_ENST00000456367.1_Missense_Mutation_p.G310E|PCDH9_ENST00000377861.3_Missense_Mutation_p.G310E|PCDH9_ENST00000377865.2_Missense_Mutation_p.G310E	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	310	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TGTAATCAGCCCAGTAGTATT	0.483000													35	103					0	0	1	0	0
LYSMD4	145748	broad.mit.edu	37	15	100272104	100272104	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:100272104T>C	ENST00000344791.2	-	3	285	c.13A>G	c.(13-15)Act>Gct	p.T5A	LYSMD4_ENST00000545021.1_5'UTR|LYSMD4_ENST00000409796.1_Missense_Mutation_p.D34G|LYSMD4_ENST00000604213.1_Intron|LYSMD4_ENST00000332728.4_Missense_Mutation_p.D34G	NM_152449.2	NP_689662.2	Q5XG99	LYSM4_HUMAN	LysM, putative peptidoglycan-binding, domain containing 4	0					cell wall macromolecule catabolic process	integral to membrane				breast(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)	10	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00162)|LUSC - Lung squamous cell carcinoma(107;0.17)|Lung(145;0.208)			GTCCCCCGAGTCCCCACTGCC	0.587000													7	30					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2082410	2082410	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:2082410A>T	ENST00000400921.2	+	6	1003	c.320A>T	c.(319-321)gAt>gTt	p.D107V	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Missense_Mutation_p.D107V	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	290	Interaction with SQSTM1 (By similarity).				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CTGGTGCATGATGACGAGGTA	0.597000													15	55					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8331712	8331712	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:8331712G>A	ENST00000381196.4	-	41	5947	c.5404C>T	c.(5404-5406)Cag>Tag	p.Q1802*	PTPRD_ENST00000355233.5_Nonsense_Mutation_p.Q1396*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.Q1802*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.Q1789*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.Q1392*|PTPRD_ENST00000358503.5_Nonsense_Mutation_p.Q1780*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.Q1395*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.Q1802*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.Q1395*|PTPRD_ENST00000397611.3_Nonsense_Mutation_p.Q1392*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.Q1395*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1802	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AACTGGAACTGCCTTACTGTT	0.507000										TSP Lung(15;0.13)			23	49					0	0	1	0	0
GPR63	81491	broad.mit.edu	37	6	97246427	97246427	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:97246427G>T	ENST00000229955.3	-	2	1526	c.1181C>A	c.(1180-1182)cCg>cAg	p.P394Q	GPR63_ENST00000417980.1_Missense_Mutation_p.P394Q	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	394						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AGGGAGCTGCGGCAAAAACTT	0.483000													24	80					4.72057e-08	4.86287e-08	1	1	0
C6orf165	154313	broad.mit.edu	37	6	88138459	88138459	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:88138459T>C	ENST00000507897.1	+	9	1159	c.1076T>C	c.(1075-1077)cTa>cCa	p.L359P	C6ORF165_ENST00000369562.4_Missense_Mutation_p.L359P			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	359										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		GCTCACGAACTATACTTTCCT	0.413000													5	129					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210558823	210558823	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:210558823T>C	ENST00000360351.4	+	7	2435	c.1929T>C	c.(1927-1929)agT>agC	p.S643S	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000447185.1_Silent_p.S639S	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	643					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TCGCACAGAGTTATCCATCAG	0.448000													21	59					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751974	140751974	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140751974A>G	ENST00000576222.1	+	1	2144	c.2013A>G	c.(2011-2013)atA>atG	p.I671M	PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAAGAGATACAACCTGACC	0.582000													7	163					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628301	29628301	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:29628301T>A	ENST00000278882.3	+	6	683	c.303T>A	c.(301-303)agT>agA	p.S101R	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106R|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101R																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AAGCAAAAAGTAAAACAGCAG	0.353000													4	90					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200954079	200954079	+	Silent	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:200954079T>A	ENST00000332129.2	-	27	4027	c.3711A>T	c.(3709-3711)acA>acT	p.T1237T	KIF21B_ENST00000461742.2_Silent_p.T1237T|KIF21B_ENST00000360529.5_Silent_p.T1237T|KIF21B_ENST00000422435.2_Silent_p.T1237T	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1237					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						ATGATGGGGGTGTGAATCCCA	0.607000													14	63					0	0	1	0	0
SUGP1	57794	broad.mit.edu	37	19	19414550	19414550	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:19414550C>A	ENST00000247001.5	-	5	992	c.645G>T	c.(643-645)aaG>aaT	p.K215N	SUGP1_ENST00000585763.1_Intron	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	215					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						CTGGGTTATCCTTGTAGTCCT	0.552000													104	322					7.59261e-44	8.05509e-44	1	1	0
ITFG2	55846	broad.mit.edu	37	12	2933264	2933264	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:2933264G>A	ENST00000228799.2	+	12	1388	c.1249G>A	c.(1249-1251)Gac>Aac	p.D417N	ITFG2_ENST00000542548.1_Missense_Mutation_p.D305N|ITFG2_ENST00000419778.2_Missense_Mutation_p.D240N	NM_018463.3	NP_060933.3	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	417										central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			AGATCCTGACGACCTCCCTGT	0.617000													7	219					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52109924	52109924	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52109924G>T	ENST00000394970.2	-	10	1376	c.1059C>A	c.(1057-1059)atC>atA	p.I353I	POC1A_ENST00000474012.1_Silent_p.I363I|POC1A_ENST00000296484.2_Silent_p.I401I	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	401						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						CTCTCTGCATGATTAGCTGCT	0.512000													46	171					9.22156e-22	9.73746e-22	1	1	0
CROCC	9696	broad.mit.edu	37	1	17265455	17265455	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17265455A>G	ENST00000375541.5	+	12	1495	c.1426A>G	c.(1426-1428)Acc>Gcc	p.T476A	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	476					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CTCTGAGCGCACCGCGGATGC	0.726000													14	70					0	0	1	0	0
THY1	7070	broad.mit.edu	37	11	119290893	119290893	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:119290893T>C	ENST00000284240.5	-	3	1280	c.241A>G	c.(241-243)Acc>Gcc	p.T81A	THY1_ENST00000527590.1_5'UTR|USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000498979.2_RNA|USP2-AS1_ENST00000500970.1_RNA|USP2-AS1_ENST00000578923.1_RNA|THY1_ENST00000580275.1_Missense_Mutation_p.T64A|THY1_ENST00000528522.1_Missense_Mutation_p.T81A	NM_006288.3	NP_006279.2	P04216	THY1_HUMAN	Thy-1 cell surface antigen	81	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		TATTTGCTGGTGAAGTTGGTT	0.557000													37	120					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43630657	43630657	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:43630657C>T	ENST00000332857.6	-	1	73	c.45G>A	c.(43-45)tcG>tcA	p.S15S		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		GGGCGTTTAGCGATGAGGCAC	0.483000													18	98					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585873	7585873	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:7585873T>C	ENST00000379802.3	+	24	8719	c.8378T>C	c.(8377-8379)aTg>aCg	p.M2793T	DSP_ENST00000418664.2_Missense_Mutation_p.M2194T	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2793	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AATCGCTCCATGGTAGAAGAT	0.542000													96	346					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139285288	139285288	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:139285288T>C	ENST00000406875.3	-	11	2404	c.2310A>G	c.(2308-2310)ctA>ctG	p.L770L	HIPK2_ENST00000428878.2_Silent_p.L743L|HIPK2_ENST00000342645.6_Silent_p.L770L	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	770	Interaction with POU4F1 (By similarity).|Interaction with SKI and SMAD1.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					GACCGGTCAATAGTGCAGGCT	0.542000													44	89					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													9	129					0	0	1	0	0
SP1	6667	broad.mit.edu	37	12	53804895	53804895	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:53804895T>C	ENST00000426431.2	+	6	2268	c.2208T>C	c.(2206-2208)ctT>ctC	p.L736L	SP1_ENST00000327443.4_Silent_p.L743L	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	743	Domain D.|VZV IE62-binding.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		CTTCAGCCCTTATTACCACCA	0.567000													4	165					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9275635	9275635	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:9275635C>T	ENST00000383440.2	+	10	6065	c.5808C>T	c.(5806-5808)gcC>gcT	p.A1936A	ANKRD12_ENST00000262126.3_Silent_p.A1959A|ANKRD12_ENST00000400020.3_Silent_p.A1936A	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1959						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						TGCTGGATGCCGAAGTATACA	0.363000													35	108					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740574	50740574	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:50740574C>T	ENST00000008391.3	+	8	1584	c.1356C>T	c.(1354-1356)gaC>gaT	p.D452D		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	452							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					AAAAGACAGACTAGCTACATC	0.448000													6	25					0	0	1	0	0
ZNF645	158506	broad.mit.edu	37	X	22291692	22291692	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:22291692A>G	ENST00000323684.1	+	1	628	c.584A>G	c.(583-585)cAt>cGt	p.H195R		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	195						intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						TCTGTGCAACATATGCTACAA	0.468000													6	79					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86806031	86806031	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:86806031T>C	ENST00000441037.2	+	9	949	c.854T>C	c.(853-855)gTg>gCg	p.V285A	AGBL1_ENST00000421325.2_Missense_Mutation_p.V285A|AGBL1_ENST00000389298.3_Missense_Mutation_p.V16A	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	285					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GAAACAGACGTGAACAAGCTG	0.433000													4	19					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182518	100182518	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:100182518G>A	ENST00000554176.1	+	4	1096	c.430G>A	c.(430-432)Gtc>Atc	p.V144I	CYP46A1_ENST00000261835.3_Missense_Mutation_p.V297I|CYP46A1_ENST00000423126.2_Missense_Mutation_p.V200I			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	297					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGACAACTTCGTCACCTTCTT	0.542000													21	69					0	0	1	0	0
AMFR	267	broad.mit.edu	37	16	56441904	56441904	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:56441904A>G	ENST00000290649.5	-	4	848	c.638T>C	c.(637-639)aTg>aCg	p.M213T		NM_001144.5	NP_001135.3	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor, E3 ubiquitin protein ligase	213					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17						CAAGGTGTGCATTCCGTGGGT	0.537000													21	43					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45814020	45814020	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:45814020G>T	ENST00000358525.4	-	5	785	c.670C>A	c.(670-672)Ctc>Atc	p.L224I	SLC6A20_ENST00000353278.4_Intron|SLC6A20_ENST00000456124.2_Missense_Mutation_p.L224I	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	224					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		ATGTACATGAGGCCATTGGTG	0.597000													12	28					2.80697e-09	2.90086e-09	1	1	0
SEC24A	10802	broad.mit.edu	37	5	133997209	133997209	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:133997209T>C	ENST00000398844.2	+	2	786	c.498T>C	c.(496-498)agT>agC	p.S166S	SEC24A_ENST00000322887.4_Silent_p.S166S	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	166	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAAATACAAGTTTAACCACAA	0.363000													24	74					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42880472	42880472	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42880472C>T	ENST00000334370.4	+	41	8517	c.7882C>T	c.(7882-7884)Cgc>Tgc	p.R2628C	MEGF8_ENST00000251268.6_Missense_Mutation_p.R2695C|MEGF8_ENST00000378073.4_Missense_Mutation_p.R289C	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2695						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GATGGCCAGCCGCCCCTTCGC	0.682000													20	41					0	0	1	0	0
COX11	1353	broad.mit.edu	37	17	53042129	53042129	+	Nonsense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:53042129T>A	ENST00000299335.3	-	2	589	c.451A>T	c.(451-453)Aaa>Taa	p.K151*	COX11_ENST00000571584.1_Nonsense_Mutation_p.K151*	NM_004375.3	NP_004366.1	Q9Y6N1	COX11_HUMAN	cytochrome c oxidase assembly homolog 11 (yeast)	151					respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|prostate(1)	9						AAGCTAATTTTAATGATTCGA	0.383000													4	71					0	0	1	0	0
MOCS3	27304	broad.mit.edu	37	20	49575406	49575406	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:49575406C>A	ENST00000244051.1	+	1	44	c.27C>A	c.(25-27)gcC>gcA	p.A9A		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	9					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						AGGTACTCGCCTTACAAGCTG	0.562000													26	92					1.55811e-20	1.6422e-20	1	1	0
D2HGDH	728294	broad.mit.edu	37	2	242680504	242680504	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:242680504A>G	ENST00000321264.4	+	3	558	c.350_splice	c.e3+1	p.R117_splice	D2HGDH_ENST00000403782.1_5'UTR|D2HGDH_ENST00000342518.6_Splice_Site_p.R117_splice|D2HGDH_ENST00000537090.1_Splice_Site_p.R117_splice	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	117	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CCACATCCTCAGGTGAGGTGG	0.637000													4	33					0	0	1	0	0
ARPC1A	10552	broad.mit.edu	37	7	98951628	98951628	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:98951628T>C	ENST00000432884.2	+	8	917	c.456T>C	c.(454-456)ggT>ggC	p.G152G	ARPC1A_ENST00000471960.1_3'UTR|ARPC1A_ENST00000262942.5_Silent_p.G199G			Q92747	ARC1A_HUMAN	actin related protein 2/3 complex, subunit 1A, 41kDa	199					actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			endometrium(3)|large_intestine(5)|liver(2)|lung(7)|ovary(1)|prostate(1)	19	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			CAGAGTTTGGTGGCAGTGGCA	0.582000													6	152					0	0	1	0	0
NAA35	60560	broad.mit.edu	37	9	88633297	88633297	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:88633297A>G	ENST00000361671.5	+	20	2034	c.1901A>G	c.(1900-1902)tAc>tGc	p.Y634C		NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	634					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						CCAGTGCACTACTTACAGTTC	0.423000													9	28					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29195914	29195914	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:29195914G>C	ENST00000240100.2	-	3	1073	c.684C>G	c.(682-684)gtC>gtG	p.V228V	DUSP4_ENST00000240101.2_Silent_p.V137V	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	228	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		AGTCCGAGGAGACATTCAACA	0.557000													4	111					0	0	1	0	0
KPNA2	3838	broad.mit.edu	37	17	66039096	66039096	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:66039096C>G	ENST00000537025.2	+	6	1267	c.647C>G	c.(646-648)cCt>cGt	p.P216R	KPNA2_ENST00000330459.3_Missense_Mutation_p.P216R			P52292	IMA2_HUMAN	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	216	NLS binding site (major) (By similarity).				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|kidney(2)|lung(9)|prostate(1)|urinary_tract(2)	22	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTTGCAGTTCCTGATATGTCA	0.398000													86	249					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144093396	144093396	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:144093396T>C	ENST00000427704.2	+	7	1331	c.1199_splice	c.e7-1	p.F401_splice	PHACTR2_ENST00000440869.2_Splice_Site_p.F412_splice|PHACTR2_ENST00000305766.6_Splice_Site_p.F321_splice|PHACTR2_ENST00000367584.4_Splice_Site_p.F389_splice|PHACTR2_ENST00000367582.3_Splice_Site_p.F332_splice	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	401							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CTTTAACAGTTTCACAACCAA	0.493000													10	75					0	0	1	0	0
WDR54	84058	broad.mit.edu	37	2	74650994	74650994	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:74650994G>C	ENST00000348227.4	+	6	507	c.419G>C	c.(418-420)gGc>gCc	p.G140A	WDR54_ENST00000409791.1_Missense_Mutation_p.G88A|WDR54_ENST00000461531.1_3'UTR	NM_032118.2	NP_115494.1	Q9H977	WDR54_HUMAN	WD repeat domain 54	140										breast(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9						ACGTGGTCAGGCCGGGTGCTG	0.552000													42	129					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220170409	220170409	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:220170409A>G	ENST00000366923.3	-	18	2726	c.2457T>C	c.(2455-2457)agT>agC	p.S819S		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	819	3 X 57 AA approximate repeats.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TTTCCAGAATACTTGCTGAGG	0.398000													5	116					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5653605	5653605	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5653605G>A	ENST00000354852.5	+	8	1279	c.1106G>A	c.(1105-1107)tGt>tAt	p.C369Y	TRIM34_ENST00000429814.2_Missense_Mutation_p.C15Y|TRIM6-TRIM34_ENST00000457787.2_Missense_Mutation_p.C15Y|HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000514226.1_Missense_Mutation_p.C15Y	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		369						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		GAGGTGACCTGTCCCATCTGC	0.537000											OREG0003725	type=REGULATORY REGION|Gene=TRIM34|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	34	117					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44177057	44177057	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:44177057C>T	ENST00000360029.3	-	2	1455	c.1172G>A	c.(1171-1173)cGc>cAc	p.R391H		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	391						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R391H(1)		central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TTTAGAGGGGCGATCCAATGT	0.507000										HNSCC(17;0.042)			54	158					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100027230	100027230	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:100027230T>C	ENST00000258428.3	-	14	2500	c.2272A>G	c.(2272-2274)Atg>Gtg	p.M758V	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Missense_Mutation_p.M757V	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	758					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTTCGTACCATGATTTTGAGA	0.428000								Direct reversal of damage					5	118					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508498	106508498	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:106508498C>T	ENST00000359195.3	+	2	802	c.492C>T	c.(490-492)gaC>gaT	p.D164D	PIK3CG_ENST00000496166.1_Silent_p.D164D|PIK3CG_ENST00000440650.2_Silent_p.D164D	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	164					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						ACGTCACTGACGTCAGCAACG	0.682000													5	37					0	0	1	0	0
PRC1	9055	broad.mit.edu	37	15	91512855	91512855	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:91512855T>C	ENST00000361188.5	-	13	2784		c.e13-2		PRC1_ENST00000361919.3_Splice_Site|PRC1-AS1_ENST00000556200.1_RNA|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000442656.2_Splice_Site|PRC1_ENST00000394249.3_Splice_Site			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1						cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					AGCGACTGGCTGCAGAGAAAG	0.502000													6	88					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124191394	124191394	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124191394A>G	ENST00000303372.5	+	16	2019	c.1891A>G	c.(1891-1893)Aca>Gca	p.T631A	TCTN2_ENST00000426174.2_Missense_Mutation_p.T630A	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	631					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		CCACCCCCTGACAAGGTACTC	0.428000													14	81					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107040176	107040176	+	Splice_Site	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:107040176C>A	ENST00000369063.3	-	6	1135		c.e6-1		RTN4IP1_ENST00000539449.1_Intron	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1							mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		CTTTCATTACCTGCCCCCCAC	0.383000													14	36					1.49906e-05	1.53131e-05	1	1	0
GPR98	84059	broad.mit.edu	37	5	89990217	89990217	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:89990217G>A	ENST00000405460.2	+	33	7740	c.7644G>A	c.(7642-7644)atG>atA	p.M2548I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2548					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCACCTCATGAACATTTCAG	0.393000													42	124					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152674485	152674485	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:152674485G>A	ENST00000367255.5	-	69	11767	c.11166C>T	c.(11164-11166)ggC>ggT	p.G3722G	SYNE1_ENST00000423061.1_Silent_p.G3707G|SYNE1_ENST00000448038.1_Silent_p.G3707G|SYNE1_ENST00000265368.4_Silent_p.G3722G|SYNE1_ENST00000341594.5_Silent_p.G3693G	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3722					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATGAGTAGAGCCATACCAAT	0.393000										HNSCC(10;0.0054)			42	132					0	0	1	0	0
TERC	7012	broad.mit.edu	37	3	169482478	169482478	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:169482478T>C	ENST00000602385.1	-	0	370					NR_001566.1																						CCGTTCCTCTTCCTGCGGCCT	0.672000									Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				6	31					0	0	1	0	0
TRIM16L	147166	broad.mit.edu	37	17	18638255	18638255	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:18638255C>T	ENST00000449552.2	+	7	2013	c.529C>T	c.(529-531)Cgc>Tgc	p.R177C	TRIM16L_ENST00000395671.4_Missense_Mutation_p.R177C|TRIM16L_ENST00000395672.2_Missense_Mutation_p.R177C|TRIM16L_ENST00000414850.2_Silent_p.T89T|TRIM16L_ENST00000395902.3_Missense_Mutation_p.R231C|TRIM16L_ENST00000572555.1_Missense_Mutation_p.R177C|TRIM16L_ENST00000571708.1_Missense_Mutation_p.R177C			Q309B1	TR16L_HUMAN	tripartite motif containing 16-like	177	B30.2/SPRY.					cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	9						GGAGGAGAACCGCAAGGTCAC	0.607000													11	80					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75889305	75889305	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:75889305G>T	ENST00000388802.4	+	4	626	c.417G>T	c.(415-417)gtG>gtT	p.V139V	SRRM3_ENST00000326382.8_Silent_p.V139V					serine/arginine repetitive matrix 3											NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						ACGGCCCAGTGGACTGTGACT	0.771000													7	9					0.000157383	0.00015972	1	1	0
SLC10A5	347051	broad.mit.edu	37	8	82606590	82606590	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:82606590A>G	ENST00000518568.1	-	1	1819	c.618T>C	c.(616-618)gcT>gcC	p.A206A		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	206						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CAACTCCAAAAGCTTGCGCCT	0.478000													59	220					0	0	1	0	0
PLA1A	51365	broad.mit.edu	37	3	119325767	119325767	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:119325767C>A	ENST00000273371.4	+	2	292	c.220C>A	c.(220-222)Caa>Aaa	p.Q74K	PLA1A_ENST00000494440.1_Missense_Mutation_p.Q58K|PLA1A_ENST00000495992.1_Missense_Mutation_p.Q74K|PLA1A_ENST00000488919.1_Intron	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A	74					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CAGTGACCTCCAAAACTCTGG	0.458000													65	187					3.07184e-27	3.25436e-27	1	1	0
CLPB	81570	broad.mit.edu	37	11	72114048	72114048	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:72114048C>T	ENST00000294053.3	-	3	677	c.504G>A	c.(502-504)tgG>tgA	p.W168*	CLPB_ENST00000340729.5_Intron|CLPB_ENST00000445069.2_Nonsense_Mutation_p.W64*|CLPB_ENST00000437826.2_Nonsense_Mutation_p.W123*|CLPB_ENST00000543042.1_5'UTR|CLPB_ENST00000538039.1_Nonsense_Mutation_p.W168*	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	168					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						TGAGTGCTGTCCAGCCAAGTC	0.498000													17	55					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421134	55421134	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:55421134G>A	ENST00000242994.3	+	2	1289	c.911G>A	c.(910-912)cGt>cAt	p.R304H		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	304					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R304H(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GGTACCCCCCGTTATGATGTT	0.458000													272	608					0	0	1	0	0
PARL	55486	broad.mit.edu	37	3	183585695	183585695	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:183585695A>G	ENST00000317096.4	-	2	339	c.279T>C	c.(277-279)taT>taC	p.Y93Y	PARL_ENST00000435888.1_Silent_p.Y93Y|PARL_ENST00000311101.5_Silent_p.Y93Y	NM_018622.5	NP_061092.3	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like	93					proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity			endometrium(2)|large_intestine(3)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	17	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCCTTATAGGATAGGGAGAAG	0.413000													14	119					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	494216	494216	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:494216A>G	ENST00000453061.2	+	2	292	c.186A>G	c.(184-186)ccA>ccG	p.P62P	PIGG_ENST00000502311.1_3'UTR|PIGG_ENST00000296306.7_5'UTR|PIGG_ENST00000310340.5_Silent_p.P62P|PIGG_ENST00000509768.1_5'UTR|PIGG_ENST00000383028.4_Silent_p.P62P|PIGG_ENST00000504346.1_5'UTR|PIGG_ENST00000536264.1_5'UTR|PIGG_ENST00000503111.1_5'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	62					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CGCTGCCACCACCTCTCTTCA	0.398000													9	45					0	0	1	0	0
BMP10	27302	broad.mit.edu	37	2	69092780	69092780	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:69092780C>T	ENST00000295379.1	-	2	1416	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	420					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						CAGCCACATTCGGAGACGGCC	0.408000													50	139					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123484353	123484353	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:123484353C>T	ENST00000529750.1	+	15	2112	c.1785C>T	c.(1783-1785)atC>atT	p.I595I	GRAMD1B_ENST00000456860.2_Silent_p.I602I|GRAMD1B_ENST00000322282.7_Silent_p.I595I|GRAMD1B_ENST00000450171.2_Silent_p.I286I	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	595						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GCCACAGGATCAAACATGTGG	0.612000													4	39					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73679470	73679470	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:73679470C>G	ENST00000339764.1	+	6	1438	c.687C>G	c.(685-687)aaC>aaG	p.N229K	DNAJB13_ENST00000537753.1_Missense_Mutation_p.N54K|DNAJB13_ENST00000543947.1_Missense_Mutation_p.N54K|RP11-167N4.2_ENST00000537019.1_RNA	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	229					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding	p.L230fs*5(1)		large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					AGAATGACAACCTCTTCTTCG	0.582000													11	44					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14508455	14508455	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:14508455G>A	ENST00000344204.4	+	57	9242	c.9218G>A	c.(9217-9219)cGc>cAc	p.R3073H	TRIO_ENST00000344135.5_Missense_Mutation_p.R572H|TRIO_ENST00000537187.1_Missense_Mutation_p.R2897H	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	3073					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.R3073H(1)		NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					ATTGAGCGGCGCAAACACCAG	0.547000													32	102					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34671726	34671726	+	Missense_Mutation	SNP	G	G	A	rs148582124		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:34671726G>A	ENST00000374789.3	-	9	1466	c.1141C>T	c.(1141-1143)Cgt>Tgt	p.R381C	PARD3_ENST00000374790.3_Missense_Mutation_p.R337C|PARD3_ENST00000545260.1_Missense_Mutation_p.R337C|PARD3_ENST00000374776.1_Missense_Mutation_p.R381C|PARD3_ENST00000374794.3_Missense_Mutation_p.R337C|PARD3_ENST00000374773.1_Missense_Mutation_p.R381C|PARD3_ENST00000350537.4_Missense_Mutation_p.R381C|PARD3_ENST00000346874.4_Missense_Mutation_p.R381C|PARD3_ENST00000545693.1_Missense_Mutation_p.R381C|PARD3_ENST00000340077.5_Missense_Mutation_p.R381C|PARD3_ENST00000374788.3_Missense_Mutation_p.R381C|PARD3_ENST00000544292.1_Missense_Mutation_p.R111C	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	381					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				GGGCTAAAACGGCTTGAATAG	0.488000													4	131					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25384061	25384061	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:25384061C>T	ENST00000405623.1	-	3	1148	c.693G>A	c.(691-693)ccG>ccA	p.P231P	POMC_ENST00000264708.3_Silent_p.P231P|POMC_ENST00000395826.2_Silent_p.P231P|POMC_ENST00000380794.1_Silent_p.P231P			P01189	COLI_HUMAN	proopiomelanocortin	231					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding	p.P231P(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TGTCCTTGGGCGGGCTGCCCC	0.642000													6	34					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115365940	115365940	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:115365940A>G	ENST00000369358.4	-	33	4072	c.3828T>C	c.(3826-3828)agT>agC	p.S1276S	NRAP_ENST00000369360.3_Silent_p.S1241S|NRAP_ENST00000360478.3_Silent_p.S1233S|NRAP_ENST00000359988.3_Silent_p.S1268S			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1268						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GGCTTACGTCACTCAGGTTGG	0.478000													19	53					0	0	1	0	0
FAM204A	63877	broad.mit.edu	37	10	120070376	120070376	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:120070376T>C	ENST00000369183.4	-	9	954	c.695A>G	c.(694-696)tAc>tGc	p.Y232C	FAM204A_ENST00000369172.4_Missense_Mutation_p.Y232C|FAM204A_ENST00000469758.1_5'UTR	NM_022063.2	NP_071346.1	Q9H8W3	F204A_HUMAN	family with sequence similarity 204, member A	232										kidney(1)|large_intestine(5)|lung(4)|ovary(1)	11						AAGTTACATGTATCCCATGTT	0.323000													22	62					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839124	62839124	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62839124C>A	ENST00000536311.1	+	7	939	c.575C>A	c.(574-576)cCt>cAt	p.P192H	MYT1_ENST00000328439.1_Missense_Mutation_p.P192H|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	192					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AAGCCAGGTCCTGGCATTGTG	0.592000													24	58					7.92952e-12	8.24765e-12	1	1	0
PVRL1	5818	broad.mit.edu	37	11	119535589	119535589	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:119535589G>A	ENST00000264025.3	-	6	1952	c.1422C>T	c.(1420-1422)gcC>gcT	p.A474A	PVRL1_ENST00000341398.2_Intron	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	474					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity	p.A474A(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GACGGGCCTCGGCCTCATCCA	0.657000													13	31					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111035	55111035	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:55111035G>A	ENST00000314721.2	+	1	409	c.359G>A	c.(358-360)cGc>cAc	p.R120H		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GCCTATGATCGCTATGTGGCT	0.468000													48	174					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90661409	90661409	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:90661409C>T	ENST00000257749.4	-	7	1123	c.416G>A	c.(415-417)gGc>gAc	p.G139D	BACH2_ENST00000537989.1_Missense_Mutation_p.G139D|RP3-512E2.2_ENST00000413986.1_RNA|BACH2_ENST00000343122.3_Missense_Mutation_p.G139D|RP3-512E2.2_ENST00000445838.1_RNA	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	139						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CACAAACAGGCCATCCTCACT	0.597000													16	77					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685673	248685673	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248685673G>A	ENST00000343414.4	+	1	758	c.726G>A	c.(724-726)tcG>tcA	p.S242S		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGACCTGTTCGTCTCACCTGG	0.463000													5	107					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231331885	231331885	+	Missense_Mutation	SNP	G	G	A	rs144727058		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:231331885G>A	ENST00000264052.5	+	13	1601	c.1246G>A	c.(1246-1248)Gca>Aca	p.A416T	SP100_ENST00000409112.1_Missense_Mutation_p.A416T|SP100_ENST00000427101.2_Missense_Mutation_p.A391T|SP100_ENST00000341950.4_Missense_Mutation_p.A416T|SP100_ENST00000409897.1_Missense_Mutation_p.A381T|SP100_ENST00000340126.4_Missense_Mutation_p.A416T|SP100_ENST00000409341.1_Missense_Mutation_p.A416T|SP100_ENST00000409824.1_Missense_Mutation_p.A391T	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	416					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GGAGGCGCCCGCAGAAGCCTC	0.527000													47	169					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12822153	12822153	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:12822153C>T	ENST00000425528.1	-	12	1431	c.1074G>A	c.(1072-1074)gcG>gcA	p.A358A	TNPO2_ENST00000356861.5_Silent_p.A358A|TNPO2_ENST00000450764.2_Silent_p.A358A|TNPO2_ENST00000592287.1_Silent_p.A358A|TNPO2_ENST00000589956.1_5'UTR|TNPO2_ENST00000441499.1_Silent_p.A358A|TNPO2_ENST00000588216.1_Silent_p.A358A			O14787	TNPO2_HUMAN	transportin 2	358					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGTCATCCTCCGCGTCCTCGG	0.627000													62	207					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19975431	19975431	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:19975431G>A	ENST00000295824.9	-	1	241	c.80C>T	c.(79-81)cCc>cTc	p.P27L	EFHB_ENST00000498089.1_5'UTR|EFHB_ENST00000344838.4_Intron	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	27					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						CAACTCCATGGGAAATTTTGT	0.483000													8	28					0	0	1	0	0
C1orf56	54964	broad.mit.edu	37	1	151021320	151021320	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:151021320A>T	ENST00000368926.5	+	1	1105	c.997A>T	c.(997-999)Atg>Ttg	p.M333L	C1orf56_ENST00000465135.1_3'UTR	NM_017860.3	NP_060330.2	Q9BUN1	CA056_HUMAN	chromosome 1 open reading frame 56	333						extracellular region				endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTTCACAGAGATGCAACCAGT	0.522000											OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	108					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47338931	47338931	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:47338931T>C	ENST00000505841.1	-	0	863					NR_002788.2																						CACTCAAAAGTATGTCCAGAA	0.383000													9	29					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52824429	52824429	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52824429T>C	ENST00000252245.5	-	5	1151	c.931A>G	c.(931-933)Aac>Gac	p.N311D		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	311	Linker 12.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		AGGTTGCGGTTGTTGTCCATG	0.572000													59	202					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153587512	153587512	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:153587512G>C	ENST00000422373.1	-	26	4562	c.4314C>G	c.(4312-4314)ttC>ttG	p.F1438L	FLNA_ENST00000369850.3_Missense_Mutation_p.F1438L|FLNA_ENST00000360319.4_Missense_Mutation_p.F1438L|FLNA_ENST00000344736.4_Missense_Mutation_p.F1438L	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1438					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGGGACCTTGAAAGGACTGC	0.632000													98	81					0	0	1	0	0
CCDC142	84865	broad.mit.edu	37	2	74702467	74702467	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:74702467A>G	ENST00000393965.3	-	7	2077	c.1681T>C	c.(1681-1683)Ttg>Ctg	p.L561L	CCDC142_ENST00000290418.4_Silent_p.L554L	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	561										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						AATCCTTGCAACACAGGCTCC	0.557000													38	104					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16973259	16973259	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:16973259A>G	ENST00000379803.1	+	9	1169	c.1155A>G	c.(1153-1155)atA>atG	p.I385M	SIN3B_ENST00000248054.5_Missense_Mutation_p.I385M	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	385	Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						GGGACGGGATAAGCCGGGAAA	0.552000													24	66					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27217744	27217744	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:27217744C>T	ENST00000380036.4	+	19	3492	c.3050C>T	c.(3049-3051)aCc>aTc	p.T1017I	TEK_ENST00000406359.4_Missense_Mutation_p.T974I|TEK_ENST00000519097.1_Missense_Mutation_p.T869I	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	1017	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GTGTACACAACCAACAGTGAT	0.428000													15	61					0	0	1	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42272027	42272027	+	Silent	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:42272027G>C	ENST00000389384.4	-	11	1061	c.753C>G	c.(751-753)gtC>gtG	p.V251V	ATXN7L3_ENST00000593073.1_5'UTR|ATXN7L3_ENST00000454077.2_Silent_p.V258V	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	251	SCA7.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GGGAGCTCTCGACCTCTGGAA	0.557000													19	46					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31583197	31583197	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:31583197T>C	ENST00000399332.1	-	32	6230	c.5742A>G	c.(5740-5742)atA>atG	p.I1914M	HECTD1_ENST00000553700.1_Missense_Mutation_p.I1914M	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1914					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCAGGTAGGTTATCAAGTCAT	0.423000													13	45					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60193834	60193834	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:60193834A>G	ENST00000267484.5	-	3	1903	c.1568T>C	c.(1567-1569)cTc>cCc	p.L523P		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	523					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGGGTAGTCGAGGAAGGAACC	0.701000													7	11					0	0	1	0	0
BORA	79866	broad.mit.edu	37	13	73318699	73318699	+	Splice_Site	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:73318699G>A	ENST00000390667.5	+	7	608	c.511_splice	c.e7+1	p.G171_splice	BORA_ENST00000377815.3_Splice_Site_p.G101_splice|BORA_ENST00000464754.1_3'UTR	NM_024808.2	NP_079084.2	Q6PGQ7	BORA_HUMAN	bora, aurora kinase A activator	171					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding										AAATATATTAGGTAAATACTG	0.318000													7	27					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67345062	67345062	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:67345062G>A	ENST00000382713.5	+	4	572	c.382G>A	c.(382-384)Gcc>Acc	p.A128T	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	128							insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				CGACCTTCTGGCCGCAGGAGT	0.527000													6	77					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27845536	27845536	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27845536G>A	ENST00000318304.8	+	28	3179	c.2896G>A	c.(2896-2898)Gaa>Aaa	p.E966K	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.E935K|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.E960K|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.E813K	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	966					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GGAAGATTCAGAAGGGACAGT	0.358000													20	170					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7521272	7521272	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7521272T>A	ENST00000359920.6	+	8	1853	c.1600T>A	c.(1600-1602)Tac>Aac	p.Y534N	ARHGEF18_ENST00000319670.9_Missense_Mutation_p.Y376N|CTD-2207O23.3_ENST00000593531.1_Missense_Mutation_p.N491K	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	534	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				AGATCAGAAATACGTCTTTGC	0.488000													16	607					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18022173	18022173	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:18022173A>G	ENST00000262608.8	+	15	2278	c.2278A>G	c.(2278-2280)Acg>Gcg	p.T760A	CECR2_ENST00000400585.2_Missense_Mutation_p.T618A|CECR2_ENST00000400573.4_Missense_Mutation_p.T759A	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	801					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CCATGGTGCTACGAACCAAGG	0.552000													14	55					0	0	1	0	0
TMED8	283578	broad.mit.edu	37	14	77809655	77809655	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:77809655G>A	ENST00000216468.7	-	5	681	c.626C>T	c.(625-627)gCg>gTg	p.A209V		NM_213601.1	NP_998766.1	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain containing 8	209	GOLD.				transport	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)	15			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		GTCATCGGTCGCAAACTCCCA	0.522000													22	55					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32157018	32157018	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:32157018C>T	ENST00000373672.3	-	19	1914	c.1398_splice	c.e19+1	p.P466_splice	COL16A1_ENST00000373668.3_Splice_Site_p.P466_splice|COL16A1_ENST00000271069.6_Splice_Site_p.P466_splice	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	466	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGTACTCACCGGGGTCCCAG	0.667000													19	51					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21136222	21136222	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:21136222T>C	ENST00000269228.5	-	8	1865	c.1311A>G	c.(1309-1311)atA>atG	p.I437M	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.I187M	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	437					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GCAGTATCTGTATGTCAAGCG	0.498000													24	84					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166571971	166571971	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:166571971G>A	ENST00000296946.2	-	9	1608	c.1140C>T	c.(1138-1140)ccC>ccT	p.P380P	T_ENST00000366871.3_Silent_p.P322P	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	380					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TGTAGTGCGCGGGGGAGCCCC	0.711000									Chordoma, Familial Clustering of				28	59					0	0	1	0	0
ZNF79	7633	broad.mit.edu	37	9	130206653	130206653	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:130206653A>G	ENST00000342483.5	+	5	1080	c.674A>G	c.(673-675)gAa>gGa	p.E225G	ZNF79_ENST00000543471.1_Missense_Mutation_p.E201G	NM_007135.2	NP_009066.2	Q15937	ZNF79_HUMAN	zinc finger protein 79	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|stomach(2)	28						GAGTGCAGTGAATGTGGGAAG	0.488000													34	114					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63230986	63230986	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:63230986T>C	ENST00000540857.1	-	6	931	c.799A>G	c.(799-801)Ata>Gta	p.I267V	HRASLS5_ENST00000301790.4_Missense_Mutation_p.I277V|HRASLS5_ENST00000539221.1_3'UTR	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201.1|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	277										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						CAGGCAGTTATTGGTTTGGGC	0.483000													56	158					0	0	1	0	0
PRKAA1	5562	broad.mit.edu	37	5	40765238	40765238	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:40765238A>G	ENST00000397128.2	-	7	932	c.924T>C	c.(922-924)tgT>tgC	p.C308C	PRKAA1_ENST00000354209.3_Silent_p.C323C	NM_006251.5|NM_206907.3	NP_006242.5|NP_996790.3	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic subunit	308					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	CAAACTTTTCACATACTTCTT	0.378000													13	133					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116617163	116617163	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:116617163A>G	ENST00000395715.3	-	4	1610	c.1033T>C	c.(1033-1035)Tat>Cat	p.Y345H	TRPS1_ENST00000519076.1_Missense_Mutation_p.Y286H|TRPS1_ENST00000520276.1_Missense_Mutation_p.Y336H|TRPS1_ENST00000519674.1_Missense_Mutation_p.Y332H|TRPS1_ENST00000220888.5_Missense_Mutation_p.Y332H	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	332					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CAGCGGAAATACTTGGTGTTC	0.408000									Langer-Giedion syndrome				35	110					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16378219	16378219	+	Missense_Mutation	SNP	C	C	T	rs121909133		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16378219C>T	ENST00000375679.4	+	14	1423	c.1312C>T	c.(1312-1314)Cgc>Tgc	p.R438C	CLCNKB_ENST00000375667.3_Missense_Mutation_p.R269C	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb									p.R438C(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTATCGGGCGCCTCTTTGG	0.617000													44	159					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1796224	1796224	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:1796224C>A	ENST00000399161.2	-	24	4036	c.3289G>T	c.(3289-3291)Gag>Tag	p.E1097*	MYT1L_ENST00000428368.2_Nonsense_Mutation_p.E1095*|MYT1L_ENST00000407844.1_Nonsense_Mutation_p.E95*	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1097					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		AGGTTGCTCTCCATCGTGGTA	0.562000													5	51					0.0381472	0.0383256	1	1	0
TMPRSS11B	132724	broad.mit.edu	37	4	69107494	69107494	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:69107494G>A	ENST00000332644.5	-	2	198	c.37C>T	c.(37-39)Cca>Tca	p.P13S		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	13					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						GTCCATAGTGGCCAAGATCTT	0.403000													8	44					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27687448	27687448	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:27687448G>A	ENST00000493901.1	-	15	2123	c.1884C>T	c.(1882-1884)ccC>ccT	p.P628P	MAP3K6_ENST00000374040.3_Silent_p.P620P|MAP3K6_ENST00000357582.2_Silent_p.P628P	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	628					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCTCCTCCGCGGGCGCCGTGG	0.721000													16	29					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102661201	102661201	+	Missense_Mutation	SNP	G	G	A	rs146623880		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:102661201G>A	ENST00000315274.6	-	10	1419	c.1352C>T	c.(1351-1353)aCg>aTg	p.T451M	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	451	Hemopexin-like 4.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		AATTCTCTTCGTTTTAGGATC	0.318000													6	24					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107155092	107155092	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:107155092T>C	ENST00000392842.1	+	18	2467	c.2053T>C	c.(2053-2055)Tac>Cac	p.Y685H	RFX4_ENST00000229387.5_Missense_Mutation_p.Y591H|RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000357881.4_Missense_Mutation_p.Y694H	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	685					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						CAACACGTGCTACACAAGCCC	0.537000													4	205					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8420636	8420636	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:8420636T>C	ENST00000337907.3	-	19	3565	c.2931A>G	c.(2929-2931)acA>acG	p.T977T	RERE_ENST00000400908.2_Silent_p.T977T|RERE_ENST00000476556.1_Silent_p.T423T|RERE_ENST00000400907.2_Intron|RERE_ENST00000377464.1_Silent_p.T709T	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	977	Pro-rich.			T -> K (in Ref. 2; no nucleotide entry).	multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGGGGTGATGTGTGGACAGGG	0.697000													9	41					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428793	48428793	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:48428793C>T	ENST00000224605.2	-	2	1358	c.1093G>A	c.(1093-1095)Gcc>Acc	p.A365T		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	365					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TTCCTCCGGGCTTTCTGCATC	0.597000													25	66					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838593	22838593	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22838593T>C	ENST00000404138.1	+	12	2938	c.2427T>C	c.(2425-2427)tgT>tgC	p.C809C	ZBTB40_ENST00000375647.4_Silent_p.C809C|ZBTB40_ENST00000374651.4_Silent_p.C697C	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	809					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CAGTGACATGTGACCTCTGTG	0.498000													19	68					0	0	1	0	0
SLC43A2	124935	broad.mit.edu	37	17	1486572	1486572	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1486572G>A	ENST00000571650.1	-	12	1594	c.1288C>T	c.(1288-1290)Cgg>Tgg	p.R430W	SLC43A2_ENST00000301335.4_Missense_Mutation_p.R426W|SLC43A2_ENST00000412517.3_Missense_Mutation_p.R289W|SLC43A2_ENST00000382147.4_Missense_Mutation_p.R430W			Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2	426					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		GCGAAGGCCCGCATGGCATTA	0.622000													47	98					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99023173	99023173	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99023173C>T	ENST00000292478.4	-	6	1232	c.982G>A	c.(982-984)Gca>Aca	p.A328T	ATP5J2-PTCD1_ENST00000413834.1_Missense_Mutation_p.A377T|PTCD1_ENST00000555673.1_Missense_Mutation_p.A377T	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCCCGAGCTGCCACCAACAGC	0.642000													14	33					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756211	248756211	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248756211G>A	ENST00000330500.2	-	1	889	c.859C>T	c.(859-861)Cct>Tct	p.P287S		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAAATGATAGGATTCAAGACA	0.388000													13	43					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105534990	105534990	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:105534990A>G	ENST00000332180.5	+	18	1840	c.1753A>G	c.(1753-1755)Aaa>Gaa	p.K585E		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	585					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						AGTAGTCATGAAAAAACTGGA	0.373000													7	134					0	0	1	0	0
IL11RA	3590	broad.mit.edu	37	9	34660857	34660857	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:34660857G>A	ENST00000555003.1	+	12	2532	c.1176G>A	c.(1174-1176)agG>agA	p.R392R	IL11RA_ENST00000441545.2_Silent_p.R392R|IL11RA_ENST00000318041.9_Silent_p.R392R			Q14626	I11RA_HUMAN	interleukin 11 receptor, alpha	392						integral to plasma membrane	cytokine receptor activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.174)	Oprelvekin(DB00038)	CCAGGCTGAGGCTGAGACGGG	0.532000													68	281					0	0	1	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13782163	13782163	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:13782163T>C	ENST00000378106.5	+	7	670	c.551T>C	c.(550-552)tTt>tCt	p.F184S	NDUFAF5_ENST00000475968.1_3'UTR|NDUFAF5_ENST00000463598.1_Missense_Mutation_p.F156S	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	184					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										GATGGAGTGTTTATCGGTGCA	0.308000													5	36					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890792	23890792	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:23890792G>A	ENST00000532292.1	-	1	383	c.289C>T	c.(289-291)Ccg>Tcg	p.P97S		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GCTGCTACCGGGGGTCCGGGC	0.637000													4	14					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25260900	25260900	+	Missense_Mutation	SNP	C	C	T	rs116094067	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:25260900C>T	ENST00000354454.3	+	21	2235	c.1406C>T	c.(1405-1407)gCc>gTc	p.A469V	LRMP_ENST00000548766.1_Missense_Mutation_p.A469V|LRMP_ENST00000547044.1_Missense_Mutation_p.A469V	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	525					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					TCTGTGGATGCCGCTCCCACA	0.498000													5	152					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24656326	24656326	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24656326T>A	ENST00000354464.6	-	7	795	c.619A>T	c.(619-621)Atc>Ttc	p.I207F	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	207					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		ATGGCCATGATCAGCTTGGGC	0.572000													34	377					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155534609	155534609	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:155534609T>A	ENST00000401878.3	+	13	2344	c.2146T>A	c.(2146-2148)Tca>Aca	p.S716T		NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	716							nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CATAGCGCCGTCACACGTGAT	0.567000													48	136					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202149997	202149997	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:202149997T>C	ENST00000358485.4	+	8	1634	c.1438T>C	c.(1438-1440)Tac>Cac	p.Y480H	CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000432109.2_Missense_Mutation_p.Y421H|CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000323492.7_Missense_Mutation_p.Y406H|CASP8_ENST00000264275.5_Missense_Mutation_p.Y438H|CASP8_ENST00000264274.9_Missense_Mutation_p.Y337H	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	421					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						GGGAACCTGGTACATCCAGTC	0.527000										HNSCC(4;0.00038)			14	75					0	0	1	0	0
GPN3	51184	broad.mit.edu	37	12	110893704	110893704	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:110893704G>A	ENST00000543199.1	-	5	683	c.599C>T	c.(598-600)gCc>gTc	p.A200V	GPN3_ENST00000228827.3_Missense_Mutation_p.A161V|GPN3_ENST00000537466.2_Missense_Mutation_p.A171V	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	161						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						AGAGATCATGGCACTCAGGGC	0.413000													16	60					0	0	1	0	0
H2BFM	286436	broad.mit.edu	37	X	103294917	103294917	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:103294917T>C	ENST00000243297.5	+	3	683	c.683T>C	c.(682-684)cTg>cCg	p.L228P	H2BFM_ENST00000355016.3_Missense_Mutation_p.L125P					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						CGACTGCTGCTGCCGGGGAAG	0.637000													4	2					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102522033	102522033	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:102522033C>T	ENST00000321521.9	+	27	3755	c.3182C>T	c.(3181-3183)gCg>gTg	p.A1061V	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.A1061V|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.A1061V			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	1061					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TCTCACTGTGCGGGCCTGTTT	0.488000													25	45					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71851566	71851566	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:71851566C>T	ENST00000373255.4	+	4	597	c.333C>T	c.(331-333)ccC>ccT	p.P111P		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	111	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						GAATTCACCCCGAACTGCTGG	0.557000													21	86					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501484	90501484	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:90501484C>T	ENST00000325643.5	+	4	2148	c.2082C>T	c.(2080-2082)acC>acT	p.T694T		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		TGCAGAAGACCGGGTTCAGGA	0.612000													35	83					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3702332	3702332	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:3702332A>G	ENST00000382622.3	+	10	1559	c.1169A>G	c.(1168-1170)gAc>gGc	p.D390G	PRMT8_ENST00000452611.2_Missense_Mutation_p.D381G|PRMT8_ENST00000261252.4_3'UTR	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	390					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			GTATCTAATGACTACAAAATG	0.502000													20	24					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143185939	143185939	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:143185939A>G	ENST00000316549.6	-	12	1617	c.1409T>C	c.(1408-1410)tTc>tCc	p.F470S		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	470					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						GACAGTGAAGAACACGAGGAG	0.483000													8	41					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10524744	10524744	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:10524744A>G	ENST00000396560.2	+	3	494	c.267A>G	c.(265-267)aaA>aaG	p.K89K	ATF7IP2_ENST00000356427.2_Silent_p.K89K|ATF7IP2_ENST00000324570.5_Silent_p.K89K|ATF7IP2_ENST00000396559.1_Silent_p.K89K|ATF7IP2_ENST00000543967.1_Intron	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						AGAAAAGTAAAGTATTCTCTC	0.338000													18	52					0	0	1	0	0
TRAP1	10131	broad.mit.edu	37	16	3712055	3712055	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3712055G>A	ENST00000575671.1	-	11	1975	c.1246C>T	c.(1246-1248)Cag>Tag	p.Q416*	DNASE1_ENST00000575152.1_3'UTR|DNASE1_ENST00000414110.2_Intron|TRAP1_ENST00000246957.5_Nonsense_Mutation_p.Q625*|TRAP1_ENST00000538171.1_Nonsense_Mutation_p.Q572*			Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	625					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				GCCAGCTGCTGCATGCGCAGG	0.672000													9	42					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44969463	44969463	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:44969463A>G	ENST00000377967.4	+	28	4186	c.4145A>G	c.(4144-4146)gAc>gGc	p.D1382G	KDM6A_ENST00000536777.1_Missense_Mutation_p.D1337G|KDM6A_ENST00000479423.1_3'UTR|KDM6A_ENST00000543216.1_Missense_Mutation_p.D1303G|KDM6A_ENST00000382899.4_Missense_Mutation_p.D1389G	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1382					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						AAAATGGAGGACCTGATGCAA	0.403000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								36	43					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104753006	104753006	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:104753006A>G	ENST00000334877.4	+	26	5211	c.4677A>G	c.(4675-4677)ggA>ggG	p.G1559G	KMT2E_ENST00000257745.4_Silent_p.G1601G|KMT2E_ENST00000311117.3_Silent_p.G1601G|SRPK2_ENST00000493638.1_Intron					lysine (K)-specific methyltransferase 2E																		CAGTTCCAGGACACCACGTGA	0.502000													4	195					0	0	1	0	0
TRAF6	7189	broad.mit.edu	37	11	36520057	36520057	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:36520057C>T	ENST00000526995.1	-	3	676	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	TRAF6_ENST00000348124.5_Missense_Mutation_p.E144K	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	144	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				TGTCTCAGTTCCATCTTGTGC	0.373000													22	66					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40392046	40392046	+	Silent	SNP	G	G	A	rs147841331		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40392046G>A	ENST00000221347.6	-	17	8347	c.8340C>T	c.(8338-8340)tgC>tgT	p.C2780C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2780	Cys-rich.|TIL 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGATGGGCACGCAGGCTTGGC	0.612000													15	46					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219563614	219563614	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:219563614G>A	ENST00000295709.3	+	26	3626	c.3347G>A	c.(3346-3348)aGc>aAc	p.S1116N	STK36_ENST00000392105.3_Missense_Mutation_p.S1095N|STK36_ENST00000440309.1_Missense_Mutation_p.S1116N|STK36_ENST00000392106.2_Missense_Mutation_p.S1095N	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1116					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CCCCTGCGCAGCCTCCTGGGC	0.602000													4	112					0	0	1	0	0
TRIM39	56658	broad.mit.edu	37	6	30308120	30308120	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30308120T>C	ENST00000376656.4	+	7	1187	c.875T>C	c.(874-876)tTa>tCa	p.L292S	TRIM39-RPP21_ENST00000513556.1_Intron|TRIM39_ENST00000396547.1_Missense_Mutation_p.L292S|TRIM39_ENST00000396548.1_Intron|TRIM39_ENST00000540416.1_Intron|TRIM39_ENST00000376659.5_Intron|TRIM39_ENST00000396551.3_Intron	NM_021253.3	NP_067076.2			tripartite motif containing 39											ovary(3)	3						CTCCTTGGATTAGTAAAAGAA	0.408000													12	55					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120176426	120176426	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:120176426C>T	ENST00000260264.4	+	8	741	c.707C>T	c.(706-708)gCc>gTc	p.A236V	POU2F3_ENST00000543440.2_Missense_Mutation_p.A234V	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	234	POU-specific.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		CGATTTGAGGCCCTCAACCTG	0.587000													8	139					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99630082	99630082	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:99630082C>T	ENST00000376460.1	-	1	162	c.82G>A	c.(82-84)Gca>Aca	p.A28T	DOCK9_ENST00000442173.1_Missense_Mutation_p.A28T|DOCK9_ENST00000339416.2_Intron|DOCK9_ENST00000448493.2_Intron	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	0					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCCTGAGCTGCATCCTTGTAT	0.517000													4	11					0	0	1	0	0
BRMS1L	84312	broad.mit.edu	37	14	36337211	36337211	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:36337211T>C	ENST00000216807.7	+	9	1026	c.827T>C	c.(826-828)aTt>aCt	p.I276T	BRMS1L_ENST00000543183.1_Missense_Mutation_p.I228T	NM_032352.3	NP_115728.2	Q5PSV4	BRM1L_HUMAN	breast cancer metastasis-suppressor 1-like	276					regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(36;0.137)|Hepatocellular(127;0.158)		Lung(8;1.7e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.00467)|all cancers(34;0.0157)|BRCA - Breast invasive adenocarcinoma(188;0.158)	GBM - Glioblastoma multiforme(112;0.0333)		ACAATATGTATTGATAAAAAA	0.353000													4	84					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102505386	102505386	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:102505386C>T	ENST00000413150.2	+	28	3425	c.3370C>T	c.(3370-3372)Cgc>Tgc	p.R1124C	MAP4K4_ENST00000347699.4_Missense_Mutation_p.R1209C|MAP4K4_ENST00000350878.4_Missense_Mutation_p.R1249C|MAP4K4_ENST00000302217.5_Missense_Mutation_p.R1012C|MAP4K4_ENST00000425019.1_Missense_Mutation_p.R1242C|MAP4K4_ENST00000456652.1_Missense_Mutation_p.R1008C|MAP4K4_ENST00000350198.4_Missense_Mutation_p.R1136C|MAP4K4_ENST00000324219.4_Missense_Mutation_p.R1290C	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	1209	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTTGTGTGAACGCAATGACAA	0.398000													9	19					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27480660	27480660	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27480660T>C	ENST00000356183.4	-	32	5041	c.5026A>G	c.(5026-5028)Aag>Gag	p.K1676E	GTF3C1_ENST00000561623.1_Missense_Mutation_p.K1676E	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1676						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						AGCTGGAACTTCATCTGGCAG	0.647000													3	8					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95822425	95822425	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:95822425G>A	ENST00000416240.2	-	6	729	c.539C>T	c.(538-540)gCc>gTc	p.A180V	SLC25A13_ENST00000542654.1_Missense_Mutation_p.A72V|SLC25A13_ENST00000265631.5_Missense_Mutation_p.A180V	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	180	EF-hand 4.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GAAGTCGATGGCTGTGACTCT	0.438000													24	75					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802539	54802539	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:54802539T>C	ENST00000391745.1	-	9	1269	c.953A>G	c.(952-954)tAc>tGc	p.Y318C	LILRA3_ENST00000391744.3_Missense_Mutation_p.Y237C|LILRA3_ENST00000251390.3_Missense_Mutation_p.Y301C					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGAGAGGTTGTATGCACCGGA	0.682000													20	30					0	0	1	0	0
ELMSAN1	91748	broad.mit.edu	37	14	74205363	74205363	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:74205363A>G	ENST00000286523.5	-	2	2131	c.1349T>C	c.(1348-1350)gTg>gCg	p.V450A	ELMSAN1_ENST00000394071.2_Missense_Mutation_p.V450A	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		GCTCTGGATCACTCCGCCCCG	0.667000													20	73					0	0	1	0	0
ELAC1	55520	broad.mit.edu	37	18	48510840	48510840	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:48510840T>C	ENST00000269466.3	+	3	639	c.532T>C	c.(532-534)Ttt>Ctt	p.F178L	ELAC1_ENST00000591429.1_Missense_Mutation_p.F178L|ELAC1_ENST00000588577.1_Intron|RP11-729L2.2_ENST00000590722.2_Intron|RP11-729L2.2_ENST00000588256.1_Intron|SMAD4_ENST00000452201.2_Intron	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	178					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		TGTAAAAGCATTTCGCCTCTT	0.403000													17	58					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33582100	33582100	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:33582100T>C	ENST00000262873.7	+	25	2814	c.2722T>C	c.(2722-2724)Ttg>Ctg	p.L908L		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	866						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GCTGCGGGGGTTGCGAGGGGC	0.657000													43	115					0	0	1	0	0
S100A7A	338324	broad.mit.edu	37	1	153390569	153390569	+	Missense_Mutation	SNP	C	C	A	rs148917755	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:153390569C>A	ENST00000368729.4	+	2	68	c.11C>A	c.(10-12)aCt>aAt	p.T4N	S100A7A_ENST00000329256.2_Missense_Mutation_p.T4N|S100A7A_ENST00000368728.2_Missense_Mutation_p.T4N	NM_176823.3	NP_789793.1	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7A	4						cytoplasm	calcium ion binding			cervix(1)|endometrium(3)|kidney(1)|lung(3)|prostate(1)|skin(2)|stomach(1)	12	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATGAGCAACACTCAAGCTGAG	0.423000													41	135					1.22674e-20	1.29326e-20	1	1	0
ARHGEF17	9828	broad.mit.edu	37	11	73021624	73021624	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:73021624C>T	ENST00000263674.3	+	1	2291	c.1941C>T	c.(1939-1941)ggC>ggT	p.G647G		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	647					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CAGATGAAGGCATTGGGGCAG	0.637000													22	54					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141537832	141537832	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:141537832G>A	ENST00000350549.3	-	3	629	c.258C>T	c.(256-258)gtC>gtT	p.V86V	PRSS37_ENST00000438520.1_Silent_p.V86V	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	86	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						TCCAGTAGCGGACGATCTGAA	0.517000													49	175					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173344436	173344436	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:173344436A>G	ENST00000375221.2	+	11	1776	c.1573A>G	c.(1573-1575)Aaa>Gaa	p.K525E	ITGA6_ENST00000409080.1_Missense_Mutation_p.K486E|ITGA6_ENST00000343713.4_Missense_Mutation_p.K481E|ITGA6_ENST00000264107.7_Missense_Mutation_p.K486E|ITGA6_ENST00000264106.6_Missense_Mutation_p.K525E|ITGA6_ENST00000409532.1_Missense_Mutation_p.K367E			P23229	ITA6_HUMAN	integrin, alpha 6	525					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CCTCCGCCAGAAAACAGCGTG	0.488000													71	234					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18054751	18054751	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:18054751C>T	ENST00000205890.5	+	40	8035	c.7697C>T	c.(7696-7698)tCt>tTt	p.S2566F		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2566	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					ACGCTCAACTCTGAGCACTTC	0.627000													14	109					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936691	15936691	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:15936691A>G	ENST00000504595.1	+	4	1353	c.872A>G	c.(871-873)cAc>cGc	p.H291R	FBXL7_ENST00000510662.1_Missense_Mutation_p.H244R|FBXL7_ENST00000329673.7_Missense_Mutation_p.H279R	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	291					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GAAGGCCTGCACACCATCGCG	0.627000													22	55					0	0	1	0	0
RINT1	60561	broad.mit.edu	37	7	105205728	105205728	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:105205728T>C	ENST00000257700.2	+	13	2122	c.1891T>C	c.(1891-1893)Ttg>Ctg	p.L631L	EFCAB10_ENST00000485614.1_3'UTR|EFCAB10_ENST00000480514.1_3'UTR	NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	631	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						TTCCAGATGGTTGTCCTTGCC	0.408000													11	51					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13679345	13679345	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:13679345A>G	ENST00000404922.3	+	18	3741	c.3622A>G	c.(3622-3624)Aag>Gag	p.K1208E	FBLN2_ENST00000535798.1_Missense_Mutation_p.K1187E|FBLN2_ENST00000295760.7_Missense_Mutation_p.K1161E|FBLN2_ENST00000492059.1_Missense_Mutation_p.K1208E	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	1161						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CGTGGAGATGAAGCTCTGGAG	0.642000													13	208					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45954196	45954196	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:45954196C>T	ENST00000260324.7	+	3	664	c.278C>T	c.(277-279)gCc>gTc	p.A93V	RP11-96O20.4_ENST00000564080.1_Missense_Mutation_p.A93V|SQRDL_ENST00000568606.1_Missense_Mutation_p.A93V	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	93							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		GGTGCTGGTGCCAAACAATTG	0.448000													19	29					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89981749	89981749	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:89981749A>G	ENST00000405460.2	+	29	6523	c.6427A>G	c.(6427-6429)Aca>Gca	p.T2143A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2143					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTGACTAGAACAGGAGGAGC	0.413000													9	29					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61777674	61777674	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:61777674G>A	ENST00000423902.2	+	38	8655	c.8176G>A	c.(8176-8178)Gcc>Acc	p.A2726T	CHD7_ENST00000524602.1_Missense_Mutation_p.A677T	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2726	Poly-Ala.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAGTGAGATCGCCAGAGCAGC	0.597000													5	25					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201779810	201779810	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:201779810A>C	ENST00000367296.4	+	24	5141	c.4721A>C	c.(4720-4722)tAc>tCc	p.Y1574S	NAV1_ENST00000367295.1_Missense_Mutation_p.Y1180S|NAV1_ENST00000367302.1_Missense_Mutation_p.Y1527S|NAV1_ENST00000367297.4_Missense_Mutation_p.Y1566S|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367300.3_Missense_Mutation_p.Y1514S|NAV1_ENST00000295624.6_Missense_Mutation_p.Y1571S	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1574					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						TTGGCCGAGTACCTGGTGGAG	0.642000													11	48					0	0	1	0	0
MARS2	92935	broad.mit.edu	37	2	198570956	198570956	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:198570956T>A	ENST00000282276.6	+	1	870	c.827T>A	c.(826-828)aTc>aAc	p.I276N	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	276					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	TCGCAGACCATCTATGTATGG	0.557000													24	68					0	0	1	0	0
DIABLO	56616	broad.mit.edu	37	12	122692969	122692969	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:122692969G>A	ENST00000464942.2	-	5	1913	c.520C>T	c.(520-522)Cgg>Tgg	p.R174W	B3GNT4_ENST00000546192.1_3'UTR|B3GNT4_ENST00000545141.1_Intron|DIABLO_ENST00000413918.1_Missense_Mutation_p.R183W|DIABLO_ENST00000267169.6_Missense_Mutation_p.R174W|RP11-512M8.5_ENST00000535844.1_3'UTR|DIABLO_ENST00000443649.3_Missense_Mutation_p.R227W|DIABLO_ENST00000353548.6_Missense_Mutation_p.R183W	NM_001278304.1	NP_001265233.1	Q9NR28	DBLOH_HUMAN	diablo, IAP-binding mitochondrial protein	227					activation of caspase activity by cytochrome c|induction of apoptosis via death domain receptors	CD40 receptor complex|cytosol|internal side of plasma membrane|mitochondrial intermembrane space	protein binding			breast(1)|endometrium(3)|large_intestine(1)|lung(1)|ovary(1)	7	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000302)|Epithelial(86;0.00051)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GACTCAGCCCGCTCCTCCCCT	0.607000													71	86					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22927162	22927162	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:22927162G>A	ENST00000166244.3	+	14	2469	c.2397G>A	c.(2395-2397)aaG>aaA	p.K799K		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	799	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGGGCGGGAAGATCCCCATCC	0.667000													22	65					0	0	1	0	0
CDC27	996	broad.mit.edu	37	17	45219268	45219268	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:45219268A>G	ENST00000066544.3	-	12	1595	c.1502T>C	c.(1501-1503)gTa>gCa	p.V501A	CDC27_ENST00000531206.1_Missense_Mutation_p.V507A|CDC27_ENST00000527547.1_Missense_Mutation_p.V500A|CDC27_ENST00000446365.2_Missense_Mutation_p.V440A	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	501					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TTGGCACAGTACCCAACCAGT	0.353000													39	153					0	0	1	0	0
TFAP2E	339488	broad.mit.edu	37	1	36056327	36056327	+	Missense_Mutation	SNP	G	G	A	rs142726594		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:36056327G>A	ENST00000373235.3	+	6	1205	c.997G>A	c.(997-999)Gct>Act	p.A333T		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	333	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CCGACAGCACGCTGACCCGGG	0.657000													7	17					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114294295	114294295	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:114294295A>G	ENST00000357077.4	+	44	11713	c.11660A>G	c.(11659-11661)tAc>tGc	p.Y3887C	ANK2_ENST00000510275.2_Missense_Mutation_p.Y485C|ANK2_ENST00000506722.1_Missense_Mutation_p.Y1793C|ANK2_ENST00000394537.3_Missense_Mutation_p.Y1802C|ANK2_ENST00000509550.1_Missense_Mutation_p.Y978C|ANK2_ENST00000264366.6_Missense_Mutation_p.Y3854C	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3854					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAAGAAGAATACATTGATGAG	0.403000													51	137					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78164614	78164614	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:78164614G>A	ENST00000573882.1	+	9	1541	c.1005G>A	c.(1003-1005)aaG>aaA	p.K335K	CARD14_ENST00000344227.2_Silent_p.K335K|CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000570421.1_Silent_p.K335K|CARD14_ENST00000392434.2_Silent_p.K98K			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	335					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGTTCCAGAAGAGTAAGATGG	0.587000													27	106					0	0	1	0	0
SH2D4B	387694	broad.mit.edu	37	10	82363435	82363435	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:82363435G>A	ENST00000339284.2	+	5	1174	c.744G>A	c.(742-744)acG>acA	p.T248T	SH2D4B_ENST00000470604.2_Silent_p.T247T|SH2D4B_ENST00000313455.4_Silent_p.T199T	NM_207372.2	NP_997255.2	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B	247										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)	13			Colorectal(32;0.229)			AGAAGGGCACGGTCGCTGGCC	0.692000													6	28					0	0	1	0	0
RBM15B	29890	broad.mit.edu	37	3	51430952	51430952	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:51430952C>T	ENST00000323686.4	+	1	2222	c.2122C>T	c.(2122-2124)Ctg>Ttg	p.L708L		NM_013286.4	NP_037418.3	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	708					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|large_intestine(5)|lung(3)	12				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GACCAAAAAGCTGAAGAATCT	0.527000													44	139					0	0	1	0	0
GZMK	3003	broad.mit.edu	37	5	54326335	54326335	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:54326335A>G	ENST00000231009.2	+	3	356	c.286A>G	c.(286-288)Aca>Gca	p.T96A	CTD-2313F11.1_ENST00000596137.1_RNA|CTD-2313F11.1_ENST00000595218.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	96	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTCCAAACAAACACTGGAGAT	0.398000													4	135					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327465	16327465	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:16327465C>T	ENST00000244769.4	-	8	2013	c.1077G>A	c.(1075-1077)agG>agA	p.R359R	ATXN1_ENST00000436367.1_Silent_p.R359R	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	359					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CCACCACGTGCCTGGACTCGT	0.677000													48	170					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98750336	98750336	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:98750336T>G	ENST00000477737.1	+	7	1126	c.922T>G	c.(922-924)Tcc>Gcc	p.S308A	VWA3B_ENST00000435344.1_Missense_Mutation_p.S308A|VWA3B_ENST00000451075.2_Missense_Mutation_p.S158A	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	308										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TCCTGCATTCTCCACAAAGGA	0.458000													6	247					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	15994655	15994655	+	Silent	SNP	T	T	C	rs79401318		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:15994655T>C	ENST00000352083.6	-	16	2264	c.2187A>G	c.(2185-2187)caA>caG	p.Q729Q	SOX6_ENST00000316399.6_Silent_p.Q709Q|SOX6_ENST00000528252.1_Silent_p.Q702Q|SOX6_ENST00000396356.3_Silent_p.Q709Q|SOX6_ENST00000527619.1_Silent_p.Q705Q|SOX6_ENST00000528429.1_Silent_p.Q729Q			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	729					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						TCTGAGGCTGTTGCCTATATA	0.423000													12	39					0	0	1	0	0
TMF1	7110	broad.mit.edu	37	3	69097622	69097622	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:69097622A>G	ENST00000543976.1	-	2	480	c.234T>C	c.(232-234)ccT>ccC	p.P78P	CTD-2013N24.2_ENST00000598783.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA|TMF1_ENST00000398559.2_Silent_p.P78P|CTD-2013N24.2_ENST00000596274.1_RNA|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000597950.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1	78					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TGATTGCTTTAGGAGAGGCTA	0.458000													62	168					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333606	28333606	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:28333606G>T	ENST00000377255.3	+	7	1458	c.1161G>T	c.(1159-1161)aaG>aaT	p.K387N	ZKSCAN3_ENST00000252211.2_Missense_Mutation_p.K387N|ZKSCAN3_ENST00000341464.5_Missense_Mutation_p.K239N	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	387					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						ACCTTATCAAGCATCAGAGAA	0.502000													4	113					0.150653	0.150988	1	1	0
RASGRF2	5924	broad.mit.edu	37	5	80419549	80419549	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:80419549C>A	ENST00000265080.4	+	16	2626	c.2559C>A	c.(2557-2559)ccC>ccA	p.P853P		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	853					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCAGATCCCCCTCAACTCCTC	0.527000													15	56					6.72482e-11	6.97693e-11	1	1	0
PAFAH1B1	5048	broad.mit.edu	37	17	2577392	2577392	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:2577392T>C	ENST00000397195.5	+	8	1161	c.710T>C	c.(709-711)gTa>gCa	p.V237A	PAFAH1B1_ENST00000397193.3_3'UTR|PAFAH1B1_ENST00000451360.2_Missense_Mutation_p.V66A	NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	237	Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						AGAGAATGGGTACGTATGGTA	0.448000													19	39					0	0	1	0	0
ACTR2	10097	broad.mit.edu	37	2	65480896	65480896	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:65480896T>C	ENST00000260641.5	+	5	640	c.483T>C	c.(481-483)gaT>gaC	p.D161D	ACTR2_ENST00000542850.1_Silent_p.D106D|ACTR2_ENST00000377982.4_Silent_p.D166D	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	161					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						ACTCTGGAGATGGTGTGACTC	0.423000													17	178					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57012089	57012089	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:57012089C>A	ENST00000370706.4	+	10	1450	c.1206C>A	c.(1204-1206)tgC>tgA	p.C402*	RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|ZNF451_ENST00000357489.3_Nonsense_Mutation_p.C402*|RP11-203B9.4_ENST00000586432.1_RNA|ZNF451_ENST00000491832.2_Nonsense_Mutation_p.C402*|RP11-203B9.4_ENST00000416069.2_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TACTCTATTGCCACAGCAGCG	0.378000													32	77					4.02929e-09	4.1631e-09	1	1	0
MUC17	140453	broad.mit.edu	37	7	100678334	100678334	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100678334A>G	ENST00000306151.4	+	3	3701	c.3637A>G	c.(3637-3639)Act>Gct	p.T1213A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1213	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCAACCTCAACTCCTGGAGA	0.512000													157	734					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102503397	102503397	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:102503397T>C	ENST00000369138.1	+	15	2994	c.2504T>C	c.(2503-2505)gTt>gCt	p.V835A	GRIK2_ENST00000369134.4_Missense_Mutation_p.V786A|GRIK2_ENST00000413795.1_Missense_Mutation_p.V835A|GRIK2_ENST00000421544.1_Missense_Mutation_p.V835A|GRIK2_ENST00000318991.6_Missense_Mutation_p.V835A|GRIK2_ENST00000369137.3_Missense_Mutation_p.V759A	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	835					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTGCTTTCAGTTTTTGTGGCA	0.403000													39	122					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10405307	10405307	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10405307G>T	ENST00000221980.4	+	9	2284	c.2221G>T	c.(2221-2223)Ggc>Tgc	p.G741C		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	741					cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGTCACTGTGGGCGTGGAATG	0.652000													20	88					4.26978e-12	4.44313e-12	1	1	0
NAP1L4	4676	broad.mit.edu	37	11	2975794	2975794	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:2975794A>G	ENST00000380542.4	-	12	1138	c.998T>C	c.(997-999)cTg>cCg	p.L333P	NAP1L4_ENST00000526115.1_Missense_Mutation_p.L333P	NM_005969.3	NP_005960.1	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	333					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)	13		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		AGTGAAGTACAGCACAGCCCG	0.507000													18	70					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745300	140745300	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140745300G>A	ENST00000518069.1	+	1	1403	c.1403G>A	c.(1402-1404)gGt>gAt	p.G468D	PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATCCCAGAGGTGTCTCTATC	0.542000													5	322					0	0	1	0	0
HHLA3	11147	broad.mit.edu	37	1	70820764	70820764	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:70820764A>G	ENST00000359875.5	+	1	270	c.130A>G	c.(130-132)Aca>Gca	p.T44A	HHLA3_ENST00000486110.1_3'UTR|HHLA3_ENST00000432224.1_Missense_Mutation_p.T44A|HHLA3_ENST00000531950.1_Missense_Mutation_p.T44A|HHLA3_ENST00000361764.4_Missense_Mutation_p.T44A|HHLA3_ENST00000370940.5_Missense_Mutation_p.T44A	NM_001036645.1	NP_001031722.1	Q9XRX5	HHLA3_HUMAN	HERV-H LTR-associating 3	44							protein binding			large_intestine(3)|lung(1)	4						cagtcaaccaacatttactga	0.507000													10	37					0	0	1	0	0
TRIM8	81603	broad.mit.edu	37	10	104404917	104404917	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:104404917C>T	ENST00000302424.6	+	1	665	c.543C>T	c.(541-543)gaC>gaT	p.D181D		NM_030912.2	NP_112174.2	Q9BZR9	TRIM8_HUMAN	tripartite motif containing 8	181						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CGGTGTGCGACGTGGAGATCC	0.642000													7	27					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228464950	228464950	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:228464950G>A	ENST00000570156.2	+	28	7889	c.7815G>A	c.(7813-7815)gcG>gcA	p.A2605A	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.A2230A|OBSCN_ENST00000359599.6_Silent_p.A1077A|OBSCN_ENST00000422127.1_Silent_p.A2230A|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1599	Ig-like 25.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding	p.A2230A(2)|p.A2414A(1)|p.A2513A(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCGAGTTCGCGGATCAGGGAG	0.642000													6	22					0	0	1	0	0
UBE2S	27338	broad.mit.edu	37	19	55915684	55915684	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55915684G>A	ENST00000264552.9	-	3	501	c.314C>T	c.(313-315)gCt>gTt	p.A105V	UBE2S_ENST00000589978.1_Silent_p.G79G	NM_014501.2	NP_055316.2	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	105					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity			lung(1)	1	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		GCCCAGCTCAGCCGTCCAGTC	0.637000													10	83					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123471338	123471338	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:123471338T>C	ENST00000360772.3	-	6	591	c.213A>G	c.(211-213)caA>caG	p.Q71Q	MYLK_ENST00000346322.5_Silent_p.Q71Q|MYLK_ENST00000359169.1_Silent_p.Q71Q|MYLK_ENST00000475616.1_Silent_p.Q71Q|MYLK_ENST00000360304.3_Silent_p.Q71Q			Q15746	MYLK_HUMAN	myosin light chain kinase	71	Ig-like C2-type 1.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGGTGATGGGTTGCCCGTTTC	0.542000													17	43					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95679679	95679679	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:95679679C>T	ENST00000298912.4	-	6	598	c.485G>A	c.(484-486)gGc>gAc	p.G162D		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	162	Actin-binding.					integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		TGAGTCTGTGCCCCCTGAGCC	0.552000													26	72					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90015943	90015943	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:90015943T>C	ENST00000268676.7	+	2	159	c.70T>C	c.(70-72)Ttg>Ctg	p.L24L	DEF8_ENST00000567874.1_Intron|DEF8_ENST00000563795.1_Intron|DEF8_ENST00000563594.1_Intron|DEF8_ENST00000570182.1_Intron|DEF8_ENST00000569453.1_Intron|DEF8_ENST00000418391.2_Intron	NM_207514.2	NP_997397.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	24					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CAGGACGCTGTTGACTCCGCA	0.677000													33	95					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76568831	76568831	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:76568831A>T	ENST00000389840.5	-	3	615	c.491T>A	c.(490-492)aTt>aAt	p.I164N	DNAH17_ENST00000585328.1_Missense_Mutation_p.I164N					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTGCTCCGGAATAGGCAGCAA	0.587000													4	18					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50906792	50906792	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50906792A>G	ENST00000440232.2	+	10	1233	c.1180A>G	c.(1180-1182)Acc>Gcc	p.T394A	POLD1_ENST00000595904.1_Missense_Mutation_p.T394A|POLD1_ENST00000599857.1_Missense_Mutation_p.T394A	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	394					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CGACGTGATCACCGGTTACAA	0.612000								DNA polymerases (catalytic subunits)					9	321					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229790109	229790109	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:229790109G>A	ENST00000258243.2	+	9	4487	c.4351G>A	c.(4351-4353)Gcc>Acc	p.A1451T		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1451						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						ATTTATGGTGGCCCAGTACGT	0.483000													5	87					0	0	1	0	0
PRC1	9055	broad.mit.edu	37	15	91522491	91522491	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:91522491T>C	ENST00000361188.5	-	8	2215	c.1004A>G	c.(1003-1005)gAt>gGt	p.D335G	PRC1_ENST00000361919.3_Missense_Mutation_p.D335G|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000442656.2_Missense_Mutation_p.D294G|PRC1_ENST00000394249.3_Missense_Mutation_p.D335G			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	335	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					AATCTCAGCATCGTGGAGCTG	0.403000													25	72					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23481613	23481613	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:23481613T>C	ENST00000376504.3	+	1	358	c.154T>C	c.(154-156)Ttc>Ctc	p.F52L		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	52					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CGAGGTGGAGTTCCTTAGCCA	0.697000													6	25					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21242616	21242616	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:21242616T>C	ENST00000233242.1	-	19	3105	c.2978A>G	c.(2977-2979)tAt>tGt	p.Y993C		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	993					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGTCAGCGGATAGTAGGAGGC	0.542000													10	35					0	0	1	0	0
ZXDA	7789	broad.mit.edu	37	X	57935379	57935379	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:57935379C>T	ENST00000358697.4	-	1	1688	c.1476G>A	c.(1474-1476)acG>acA	p.T492T		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	492	Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						GTTCGGCCCTCGTGAAAGATT	0.547000													3	46					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59895032	59895032	+	Missense_Mutation	SNP	C	C	T	rs150780889	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:59895032C>T	ENST00000265036.5	-	10	1365	c.1298G>A	c.(1297-1299)cGt>cAt	p.R433H	DEPDC1B_ENST00000545085.1_Intron|DEPDC1B_ENST00000453022.2_Intron	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	433					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				ACTAATTTGACGGCAAAATGA	0.393000													13	53					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62786084	62786084	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:62786084A>G	ENST00000280377.5	+	18	2395	c.2337A>G	c.(2335-2337)aaA>aaG	p.K779K	USP15_ENST00000393654.3_Silent_p.K754K|USP15_ENST00000353364.3_Silent_p.K750K	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	779					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TGGAGTATAAACCTCCTAAAA	0.308000													6	35					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22283690	22283690	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:22283690A>G	ENST00000324559.8	+	16	1963	c.1646A>G	c.(1645-1647)tAc>tGc	p.Y549C	CTD-3064C13.1_ENST00000526935.1_RNA	NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	549						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTCGAACATACCAGGAGTAT	0.348000													4	81					0	0	1	0	0
SNPH	9751	broad.mit.edu	37	20	1286147	1286147	+	Missense_Mutation	SNP	C	C	T	rs151069955		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:1286147C>T	ENST00000381867.1	+	7	1708	c.1066C>T	c.(1066-1068)Cgt>Tgt	p.R356C	SNPH_ENST00000381873.3_Missense_Mutation_p.R312C			O15079	SNPH_HUMAN	syntaphilin	312					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			endometrium(2)|large_intestine(4)|lung(10)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CATGCAGGAGCGTGCCATCCA	0.622000													25	103					0	0	1	0	0
STRBP	55342	broad.mit.edu	37	9	125890530	125890530	+	Silent	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:125890530T>A	ENST00000447404.2	-	17	2209	c.1905A>T	c.(1903-1905)ggA>ggT	p.G635G	STRBP_ENST00000348403.5_Silent_p.G635G|STRBP_ENST00000360998.3_Silent_p.G621G			Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	635					multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(6)|prostate(1)|skin(2)	26						CATATGGTGTTCCATAGCCTA	0.512000													17	49					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56355299	56355299	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:56355299C>T	ENST00000340482.3	-	6	1365	c.1189G>A	c.(1189-1191)Gtc>Atc	p.V397I	MPO_ENST00000225275.3_Missense_Mutation_p.V365I|MPO_ENST00000578493.1_5'UTR			P05164	PERM_HUMAN	myeloperoxidase	365					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	CGCTGGTTGACGGCCAGCAGC	0.657000													26	65					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139145030	139145030	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:139145030C>T	ENST00000395297.1	-	20	4197	c.4027G>A	c.(4027-4029)Gca>Aca	p.A1343T		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1343										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATCATTTCTGCATAAACTGGC	0.488000										HNSCC(54;0.14)			7	302					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116627929	116627929	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:116627929T>C	ENST00000260210.4	-	9	1722	c.1699A>G	c.(1699-1701)Agt>Ggt	p.S567G	BUD13_ENST00000375445.3_Missense_Mutation_p.S433G	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	567										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GCTGGACCACTGTAGCGAGGT	0.423000													12	31					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150936071	150936071	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:150936071A>G	ENST00000271640.5	+	20	3713	c.3523A>G	c.(3523-3525)Att>Gtt	p.I1175V	SETDB1_ENST00000368969.4_Missense_Mutation_p.I1175V	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	1175	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AACCCATGGGATTGCAATTAA	0.507000													71	287					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104341488	104341488	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:104341488T>C	ENST00000361820.3	-	7	3521	c.2921A>G	c.(2920-2922)cAc>cGc	p.H974R		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	974	PPP2CB binding site (By similarity).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTGGCTGGTGTGGAGCCAGTA	0.473000													22	73					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62328129	62328129	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:62328129G>A	ENST00000318100.4	+	36	4743	c.3916G>A	c.(3916-3918)Gct>Act	p.A1306T	RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.A1306T|TNFRSF6B_ENST00000369996.1_Silent_p.A3A			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	0					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CCATGAGGGCGCTGGAGGGGC	0.697000													6	7					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53189550	53189550	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:53189550A>G	ENST00000417996.2	-	1	351	c.277T>C	c.(277-279)Tat>Cat	p.Y93H	KRT3_ENST00000309505.3_Missense_Mutation_p.Y93H	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	93	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						ccacctccatagccacctgca	0.642000													14	238					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5330489	5330489	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:5330489A>G	ENST00000396872.2	+	3	457	c.296A>G	c.(295-297)tAc>tGc	p.Y99C	SLC29A4_ENST00000406453.3_Missense_Mutation_p.Y99C|SLC29A4_ENST00000297195.4_Missense_Mutation_p.Y99C	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	99					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CATCACAAGTACCCAGGTGGG	0.627000													31	89					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198916	20198916	+	Silent	SNP	C	C	T	rs28637443	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:20198916C>T	ENST00000400331.5	-	5	1376	c.1068G>A	c.(1066-1068)ccG>ccA	p.P356P	MACC1_ENST00000332878.4_Silent_p.P356P|MACC1_ENST00000589011.1_Silent_p.P356P	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	356					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						CAGCTGGTGACGGAAGAGCTT	0.403000													19	43					0	0	1	0	0
OR8B3	390271	broad.mit.edu	37	11	124266967	124266967	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:124266967T>C	ENST00000354597.3	-	1	297	c.281A>G	c.(280-282)tAt>tGt	p.Y94C		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GCACCCAACATAGGAGATAAT	0.368000													28	63					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196963354	196963354	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:196963354T>C	ENST00000367414.5	+	4	703	c.647T>C	c.(646-648)tTt>tCt	p.F216S	CFHR5_ENST00000256785.4_Missense_Mutation_p.F192S	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	192	Sushi 4.		N -> S (in a breast cancer sample; somatic mutation).		complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						TGTTACCAATTTGGGTGGTCA	0.323000													36	108					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133363304	133363304	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133363304C>T	ENST00000204726.3	-	14	3439	c.2881G>A	c.(2881-2883)Gaa>Aaa	p.E961K	GOLGA3_ENST00000545875.1_Missense_Mutation_p.E961K|GOLGA3_ENST00000456883.2_Missense_Mutation_p.E961K|GOLGA3_ENST00000450791.2_Missense_Mutation_p.E961K|GOLGA3_ENST00000537452.1_Missense_Mutation_p.E961K	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	961					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGCAACTCTTCGATTTGTTTC	0.637000													10	270					0	0	1	0	0
HOXA4	3201	broad.mit.edu	37	7	27170286	27170286	+	Missense_Mutation	SNP	A	A	G	rs144521145		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:27170286A>G	ENST00000360046.5	-	1	132	c.67T>C	c.(67-69)Tac>Cac	p.Y23H	HOXA-AS2_ENST00000521159.1_RNA|HOXA3_ENST00000467897.2_Intron|HOXA4_ENST00000428284.2_Missense_Mutation_p.Y23H|HOXA-AS3_ENST00000518848.1_RNA	NM_002141.4	NP_002132.3	Q00056	HXA4_HUMAN	homeobox A4	23	Pro-rich (part of the transcriptional activation domain).					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)	12						TGCTGCGCGTACTCCTCGAAG	0.607000													3	15					0	0	1	0	0
ZNF576	79177	broad.mit.edu	37	19	44103349	44103349	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:44103349A>G	ENST00000336564.4	+	3	606	c.452A>G	c.(451-453)gAc>gGc	p.D151G	SRRM5_ENST00000526798.1_Intron|ZNF576_ENST00000533118.1_Missense_Mutation_p.D151G|ZNF576_ENST00000391965.2_Missense_Mutation_p.D151G|ZNF576_ENST00000528387.1_Missense_Mutation_p.D151G|ZNF576_ENST00000529930.1_Missense_Mutation_p.D151G|SRRM5_ENST00000607544.1_Intron|ZNF576_ENST00000525771.1_Missense_Mutation_p.D151G	NM_001145347.1	NP_001138819.1	Q9H609	ZN576_HUMAN	zinc finger protein 576	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|prostate(1)	2		Prostate(69;0.0199)				TGCGGTCAGGACTTTGCTCAG	0.622000													17	49					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66223200	66223200	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:66223200T>C	ENST00000409699.2	-	11	1541	c.1369A>G	c.(1369-1371)Acc>Gcc	p.T457A	MEGF11_ENST00000288745.3_Missense_Mutation_p.T382A|MEGF11_ENST00000422354.1_Missense_Mutation_p.T457A|MEGF11_ENST00000360698.4_Missense_Mutation_p.T457A|MEGF11_ENST00000395625.2_Missense_Mutation_p.T382A|MEGF11_ENST00000395614.1_5'UTR			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	457	EGF-like 8.					basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						GGGGAGCAGGTGCCACCATTG	0.577000													13	93					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	100971111	100971111	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:100971111C>T	ENST00000375066.5	-	9	2080	c.1989G>A	c.(1987-1989)gaG>gaA	p.E663E	TBC1D2_ENST00000342112.5_Silent_p.E445E|TBC1D2_ENST00000375064.1_Silent_p.E663E|TBC1D2_ENST00000493589.2_5'UTR|TBC1D2_ENST00000375063.1_Silent_p.E203E	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	663	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CAGCAGGGTGCTCGCGGGCCT	0.662000													16	77					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3118981	3118981	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:3118981A>G	ENST00000078429.4	+	5	907	c.665A>G	c.(664-666)aAc>aGc	p.N222S	AC005262.3_ENST00000587701.1_RNA|GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	222					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		TGCTTTGAGAACGTGACATCC	0.627000			Mis		uveal melanoma								5	159					0	0	1	0	0
DONSON	29980	broad.mit.edu	37	21	34953747	34953747	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:34953747T>C	ENST00000453626.1	-	8	1215	c.1211A>G	c.(1210-1212)aAa>aGa	p.K404R	DONSON_ENST00000303071.5_Missense_Mutation_p.K404R|DONSON_ENST00000432378.1_Missense_Mutation_p.K404R|DONSON_ENST00000303113.6_Missense_Mutation_p.K390R			Q9NYP3	DONS_HUMAN	downstream neighbor of SON	404					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						GTTGATTCCTTTTACCAACAC	0.403000													16	42					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241658575	241658575	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:241658575G>A	ENST00000498729.2	-	47	5308	c.5062C>T	c.(5062-5064)Ccg>Tcg	p.P1688S	KIF1A_ENST00000320389.7_Missense_Mutation_p.P1587S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1587					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GACGTGTGCGGCTCCAGGAAG	0.647000													10	166					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962520	10962520	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:10962520G>A	ENST00000240691.2	-	1	247	c.155C>T	c.(154-156)gCc>gTc	p.A52V		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	52					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TCTGGAGATGGCCAAGCTGAT	0.408000													54	103					0	0	1	0	0
MRPL45	84311	broad.mit.edu	37	17	36476503	36476503	+	Splice_Site	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:36476503A>G	ENST00000312513.5	+	6	673	c.510_splice	c.e6-1	p.D171_splice		NM_032351.4	NP_115727.4	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45	171					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome			breast(3)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	13	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TGCCCTTAGGACATGACTTGG	0.468000													5	251					0	0	1	0	0
TRIP6	7205	broad.mit.edu	37	7	100468206	100468206	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:100468206T>C	ENST00000200457.4	+	6	1200	c.840T>C	c.(838-840)ggT>ggC	p.G280G		NM_003302.2	NP_003293.2	Q15654	TRIP6_HUMAN	thyroid hormone receptor interactor 6	280	LIM zinc-binding 1.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCCAGTGTGGTGGCTGCGGAG	0.612000													24	78					0	0	1	0	0
PRRT1	80863	broad.mit.edu	37	6	32117026	32117026	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:32117026C>T	ENST00000211413.5	-	4	1018	c.894G>A	c.(892-894)caG>caA	p.Q298Q	PRRT1_ENST00000375152.2_Silent_p.Q217Q|PRRT1_ENST00000375150.2_Silent_p.Q217Q|PRRT1_ENST00000467780.1_5'UTR	NM_030651.3	NP_085154.3	Q99946	PRRT1_HUMAN	proline-rich transmembrane protein 1	298					response to biotic stimulus	integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						TCTCGTGGTGCTGCGCGGCGA	0.632000													14	36					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22078939	22078939	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:22078939T>C	ENST00000261200.4	-	3	342	c.343A>G	c.(343-345)Act>Gct	p.T115A	ABCC9_ENST00000538350.1_Missense_Mutation_p.T115A|ABCC9_ENST00000345162.2_Missense_Mutation_p.T115A|ABCC9_ENST00000261201.4_Missense_Mutation_p.T115A|ABCC9_ENST00000326684.4_Missense_Mutation_p.T115A	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	115					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GATGTTGTAGTGGCAACGAAT	0.413000													9	152					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245849150	245849150	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:245849150G>A	ENST00000366518.4	+	9	1826	c.1722G>A	c.(1720-1722)ggG>ggA	p.G574G	KIF26B_ENST00000407071.2_Silent_p.G955G			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	955	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CTCAGTTTGGGCCAGAGCAGG	0.592000													13	42					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32198968	32198968	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:32198968A>G	ENST00000346541.3	+	4	811	c.274A>G	c.(274-276)Aat>Gat	p.N92D	CBFA2T2_ENST00000359606.3_Missense_Mutation_p.N102D|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.N63D|CBFA2T2_ENST00000342704.5_Missense_Mutation_p.N83D|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.N92D|CBFA2T2_ENST00000344201.3_Missense_Mutation_p.N63D|CBFA2T2_ENST00000397798.2_Missense_Mutation_p.N63D	NM_005093.3	NP_005084.1	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	92	Pro-rich.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						GAGATTCAGCAATGGTCCTGC	0.483000													7	148					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112665919	112665919	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:112665919A>G	ENST00000550722.1	-	43	6785	c.6390T>C	c.(6388-6390)gtT>gtC	p.V2130V	HECTD4_ENST00000430131.2_Silent_p.V1854V|HECTD4_ENST00000377560.5_Silent_p.V2104V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CAAGGAGCCGAACGACTGCCA	0.537000													24	128					0	0	1	0	0
PSMB5	5693	broad.mit.edu	37	14	23495455	23495455	+	Missense_Mutation	SNP	T	T	C	rs60224002		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23495455T>C	ENST00000361611.6	-	3	898	c.635A>G	c.(634-636)tAt>tGt	p.Y212C	PSMB5_ENST00000425762.2_Missense_Mutation_p.Y109C|PSMB5_ENST00000493471.2_3'UTR|PSMB5_ENST00000460922.2_3'UTR	NM_002797.3	NP_002788.1	P28074	PSB5_HUMAN	proteasome (prosome, macropain) subunit, beta type, 5	212					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	GGCCAGATCATAGGCCTGCTC	0.567000													28	227					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46790092	46790092	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:46790092T>C	ENST00000262738.3	-	14	5910	c.5911A>G	c.(5911-5913)Agc>Ggc	p.S1971G		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1971	EGF-like 7; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AAGCCTTTGCTGACGGCACAG	0.592000													23	63					0	0	1	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378346	31378346	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:31378346G>A	ENST00000297142.3	-	2	859	c.537C>T	c.(535-537)ggC>ggT	p.G179G		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	179					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						GCTGCAAGCAGCCTGCCACCA	0.517000													42	102					0	0	1	0	0
HAS2	3037	broad.mit.edu	37	8	122641078	122641078	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:122641078G>A	ENST00000303924.4	-	2	1040	c.503C>T	c.(502-504)tCg>tTg	p.S168L		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	168						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TACGTGTTGCGAGCTTTCTTT	0.448000													167	276					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27231984	27231984	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:27231984C>T	ENST00000286096.4	+	8	1357	c.1184C>T	c.(1183-1185)cCg>cTg	p.P395L	KDM8_ENST00000380948.2_Missense_Mutation_p.P199L|KDM8_ENST00000441782.2_Missense_Mutation_p.P433L|KDM8_ENST00000568965.1_Missense_Mutation_p.P199L|KDM8_ENST00000567785.1_3'UTR	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	395	JmjC.				G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										CTGTTCATCCCGGTGAAATAC	0.552000													47	175					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128180493	128180493	+	Splice_Site	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:128180493C>T	ENST00000453608.2	+	4	309	c.300_splice	c.e4-1	p.L101_splice	PROC_ENST00000409048.1_Splice_Site_p.L80_splice|PROC_ENST00000422777.3_Splice_Site_p.L80_splice|PROC_ENST00000234071.3_Splice_Site_p.L80_splice			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	80	EGF-like 1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	CTCTCCGCAGCTGGCCTTCTG	0.741000													3	6					0	0	1	0	0
CAP1	10487	broad.mit.edu	37	1	40535434	40535434	+	Missense_Mutation	SNP	G	G	A	rs35749351		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:40535434G>A	ENST00000372797.3	+	9	1442	c.881G>A	c.(880-882)cGc>cAc	p.R294H	CAP1_ENST00000372798.1_Missense_Mutation_p.R293H|CAP1_ENST00000479759.1_3'UTR|CAP1_ENST00000372805.3_Missense_Mutation_p.R294H|CAP1_ENST00000372792.2_Missense_Mutation_p.R294H|CAP1_ENST00000372802.1_Missense_Mutation_p.R293H|CAP1_ENST00000340450.3_Missense_Mutation_p.R293H	NM_001105530.1|NM_006367.3	NP_001099000.1|NP_006358.1	Q01518	CAP1_HUMAN	CAP, adenylate cyclase-associated protein 1 (yeast)	294					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGTCCAGTACGCAGTGGCCCC	0.522000													58	198					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56473886	56473886	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:56473886G>A	ENST00000370754.5	-	39	5440	c.5441C>T	c.(5440-5442)gCt>gTt	p.A1814V	DST_ENST00000370769.4_Missense_Mutation_p.A1636V|DST_ENST00000312431.6_Missense_Mutation_p.A1636V|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000446842.2_Missense_Mutation_p.A1310V|DST_ENST00000361203.3_Missense_Mutation_p.A1636V|DST_ENST00000244364.6_Intron			Q03001	DYST_HUMAN	dystonin	1636					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGGTGACGCAGCAGAAATAAT	0.408000													6	308					0	0	1	0	0
TRAV27	28655	broad.mit.edu	37	14	22616437	22616437	+	RNA	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:22616437G>T	ENST00000390457.2	+	0	275																											GCCTGGGGAAGGTCCTGTCCT	0.468000													17	55					1.15088e-07	1.18287e-07	1	1	0
ZEB1	6935	broad.mit.edu	37	10	31816166	31816166	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:31816166T>C	ENST00000446923.2	+	9	3692	c.3301T>C	c.(3301-3303)Tct>Cct	p.S1101P	ZEB1_ENST00000542815.3_Missense_Mutation_p.S1050P|ZEB1_ENST00000320985.10_Missense_Mutation_p.S1117P|ZEB1_ENST00000361642.5_Missense_Mutation_p.S1118P|ZEB1_ENST00000560721.2_Missense_Mutation_p.S1097P	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1117	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGAGCAAGTGTCTGAAGAAAA	0.373000													16	35					0	0	1	0	0
BBS1	582	broad.mit.edu	37	11	66281968	66281968	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66281968C>A	ENST00000419755.3	+	4	440	c.362C>A	c.(361-363)gCt>gAt	p.A121D	BBS1_ENST00000455748.2_Missense_Mutation_p.A84D|BBS1_ENST00000393994.2_Missense_Mutation_p.A84D|BBS1_ENST00000537537.1_5'UTR|BBS1_ENST00000529766.1_3'UTR|BBS1_ENST00000318312.7_Missense_Mutation_p.A84D																							CCGCTACCTGCTCTGCCAGCT	0.607000													8	368					0.000274275	0.00027791	1	1	0
FBXO46	23403	broad.mit.edu	37	19	46216140	46216140	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:46216140T>C	ENST00000317683.3	-	2	747	c.614A>G	c.(613-615)gAg>gGg	p.E205G		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	205							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		TCCACCTTGCTCGGCGGACAC	0.687000													21	22					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133306	47133306	+	RNA	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:47133306T>C	ENST00000422732.2	-	0	435					NR_033957.1																						TCTCTGGCTCTCCTCTCCTGC	0.483000													10	42					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146033465	146033465	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:146033465T>C	ENST00000296577.4	+	9	1300	c.785T>C	c.(784-786)cTa>cCa	p.L262P	ABCE1_ENST00000502803.1_Intron|OTUD4_ENST00000455611.2_Intron	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	262	ABC transporter 1.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					ATACGATCTCTAATAAATCCA	0.328000													8	13					0	0	1	0	0
M6PR	4074	broad.mit.edu	37	12	9098992	9098992	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:9098992A>G	ENST00000000412.3	-	2	477	c.9T>C	c.(7-9)ccT>ccC	p.P3P		NM_002355.3	NP_002346.1	P20645	MPRD_HUMAN	mannose-6-phosphate receptor (cation dependent)	3					endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(1)	11		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)		AGCTGTAGAAAGGGAACATCC	0.488000													14	71					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130949633	130949633	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:130949633A>G	ENST00000312988.7	-	5	1224	c.1124T>C	c.(1123-1125)gTg>gCg	p.V375A		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	375					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					CAGCATGCACACGGCCCGCTG	0.612000													5	128					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85991728	85991728	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:85991728G>T	ENST00000372105.3	-	4	1848	c.1827C>A	c.(1825-1827)gcC>gcA	p.A609A		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	609						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						TGACTCCAAAGGCCTGAAAGT	0.577000													8	28					0.000157383	0.00015972	1	1	0
CDCA2	157313	broad.mit.edu	37	8	25364677	25364677	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:25364677G>A	ENST00000330560.3	+	15	2972	c.2495G>A	c.(2494-2496)cGt>cAt	p.R832H	CDCA2_ENST00000521098.2_3'UTR|CDCA2_ENST00000380665.3_Missense_Mutation_p.R817H	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	832					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GATAGAAGACGTTCCATGTGT	0.398000													18	83					0	0	1	0	0
PTPN1	5770	broad.mit.edu	37	20	49197817	49197817	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:49197817T>C	ENST00000371621.3	+	9	1278	c.1104T>C	c.(1102-1104)acT>acC	p.T368T	PTPN1_ENST00000541713.1_Silent_p.T295T	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	368					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	GTCAAGACACTGAAGTTAGAA	0.552000													18	62					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49620945	49620945	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:49620945G>A	ENST00000371571.4	-	3	1458	c.1173C>T	c.(1171-1173)ttC>ttT	p.F391F	RP5-955M13.4_ENST00000424566.1_RNA|RP5-955M13.3_ENST00000506387.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	391						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCAGGGGCGCGAAGAGGGCGA	0.677000													14	32					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41938363	41938363	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:41938363A>G	ENST00000301831.4	-	15	1943	c.1481T>C	c.(1480-1482)gTg>gCg	p.V494A	ULK4_ENST00000420927.1_Missense_Mutation_p.V494A	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	494							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ACCAGCCACCACGCACAAATA	0.517000													31	97					0	0	1	0	0
CASP6	839	broad.mit.edu	37	4	110618836	110618836	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:110618836G>A	ENST00000265164.2	-	3	249	c.172C>T	c.(172-174)Cac>Tac	p.H58Y	CASP6_ENST00000505486.1_Missense_Mutation_p.H58Y|CASP6_ENST00000352981.3_Intron	NM_001226.3	NP_001217.2	P55212	CASP6_HUMAN	caspase 6, apoptosis-related cysteine peptidase	58					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		AGTGTTAAGTGCCAAAAGAAC	0.428000													14	55					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151787617	151787617	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:151787617G>T	ENST00000356728.6	-	4	674	c.520C>A	c.(520-522)Ctc>Atc	p.L174I	RORC_ENST00000392697.3_Missense_Mutation_p.L249I|RORC_ENST00000318247.6_Missense_Mutation_p.L195I	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	195	Hinge (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCCCATTGAGCCCTGCCTTG	0.622000													15	19					1.3612e-06	1.39554e-06	1	1	0
TRMT6	51605	broad.mit.edu	37	20	5924869	5924869	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:5924869T>C	ENST00000203001.2	-	4	527	c.397A>G	c.(397-399)Aca>Gca	p.T133A	TRMT6_ENST00000473131.1_5'UTR|TRMT6_ENST00000453074.2_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	133					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						CGGAATGTTGTACTATTTTCA	0.284000													5	24					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90190254	90190254	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:90190254A>G	ENST00000394412.3	-	7	1671	c.1595T>C	c.(1594-1596)gTg>gCg	p.V532A		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	532					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CCGCAGTTCCACCATCTCCTC	0.652000											OREG0023460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	22					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107576055	107576055	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:107576055T>C	ENST00000393561.1	-	25	4249	c.4065A>G	c.(4063-4065)gcA>gcG	p.A1355A	LAMB1_ENST00000222399.6_Silent_p.A1331A|LAMB1_ENST00000474380.1_5'UTR			P07942	LAMB1_HUMAN	laminin, beta 1	1331	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCTCTCCTCTGCCTCAAGAG	0.493000													36	133					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176895114	176895114	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:176895114T>C	ENST00000292385.5	-	4	865	c.256A>G	c.(256-258)Aac>Gac	p.N86D	DBN1_ENST00000309007.5_Missense_Mutation_p.N84D|DBN1_ENST00000393565.1_Missense_Mutation_p.N84D	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	84	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATACCCAGTTGATGAGCACG	0.617000													113	393					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2841160	2841160	+	Silent	SNP	C	C	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:2841160C>A	ENST00000380445.3	+	5	507	c.435C>A	c.(433-435)gcC>gcA	p.A145A	VPS16_ENST00000380469.3_Silent_p.A145A	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	145					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						CCGGAGTGGCCATCCTCACAG	0.607000													22	74					1.28384e-07	1.31923e-07	1	1	0
NAA16	79612	broad.mit.edu	37	13	41941733	41941733	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:41941733G>C	ENST00000379406.3	+	14	2022	c.1698G>C	c.(1696-1698)ttG>ttC	p.L566F	NAA16_ENST00000497143.1_3'UTR	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	566					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						AAATATACTTGAAATTGTATG	0.328000													8	24					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162902056	162902056	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:162902056A>G	ENST00000360534.3	-	5	912	c.352T>C	c.(352-354)Tac>Cac	p.Y118H		NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	118					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	ACGTAGTTGTATTCTAAGAGA	0.303000													12	53					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52697557	52697557	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:52697557C>T	ENST00000399231.3	-	9	1223	c.980G>A	c.(979-981)cGa>cAa	p.R327Q	MYO5A_ENST00000553916.1_Missense_Mutation_p.R327Q|MYO5A_ENST00000356338.6_Missense_Mutation_p.R327Q|MYO5A_ENST00000399233.2_Missense_Mutation_p.R327Q|MYO5A_ENST00000358212.6_Missense_Mutation_p.R327Q	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	327	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		AGCAAGTATTCGGAAAATTCC	0.378000													12	34					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139798694	139798694	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:139798694G>C	ENST00000397560.2	-	14	2000	c.1903C>G	c.(1903-1905)Caa>Gaa	p.Q635E	JHDM1D_ENST00000006967.5_Missense_Mutation_p.Q635E	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		635					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					AGTGGTTTTTGAGATTCTTCA	0.303000													6	39					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10386368	10386368	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:10386368G>T	ENST00000377086.1	+	27	3077	c.2875G>T	c.(2875-2877)Ggg>Tgg	p.G959W	KIF1B_ENST00000263934.6_Missense_Mutation_p.G913W|KIF1B_ENST00000377081.1_Missense_Mutation_p.G959W			O60333	KIF1B_HUMAN	kinesin family member 1B	959					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTTCAGTGACGGGCATGACCC	0.527000													34	101					3.11337e-16	3.26767e-16	1	1	0
APEX1	328	broad.mit.edu	37	14	20924986	20924986	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20924986C>T	ENST00000216714.3	+	4	674	c.406C>T	c.(406-408)Cgc>Tgc	p.R136C	APEX1_ENST00000555414.1_Missense_Mutation_p.R136C|APEX1_ENST00000557054.1_Intron|APEX1_ENST00000557365.1_3'UTR|APEX1_ENST00000398030.4_Missense_Mutation_p.R136C	NM_001244249.1|NM_001641.3	NP_001231178.1|NP_001632.2	P27695	APEX1_HUMAN	APEX nuclease (multifunctional DNA repair enzyme) 1	136					base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			breast(2)|endometrium(1)|large_intestine(4)|ovary(2)	9	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	CCTGCTTTCCCGCCAGTGCCC	0.507000								Other BER factors					3	31					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113189972	113189972	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:113189972A>G	ENST00000401783.2	-	36	6210	c.5874T>C	c.(5872-5874)tgT>tgC	p.C1958C	SVEP1_ENST00000297826.5_5'UTR|SVEP1_ENST00000374469.1_Silent_p.C1935C	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1958	Sushi 9.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AGACGAGGTGACAGGCAGGTG	0.498000											OREG0019389	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	108					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120388409	120388409	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:120388409T>A	ENST00000602047.1	+	20	2160	c.1048T>A	c.(1048-1050)Tca>Aca	p.S350T	PCDP1_ENST00000413369.3_Missense_Mutation_p.S636T			Q4G0U5	PCDP1_HUMAN		636						cilium	calmodulin binding					Colorectal(110;0.196)					TGGCAAAACATCAGTCTTGAG	0.458000													49	122					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451637	55451637	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:55451637T>C	ENST00000588756.1	-	6	1036	c.550A>G	c.(550-552)Aaa>Gaa	p.K184E	NLRP7_ENST00000328092.5_Missense_Mutation_p.K184E|NLRP7_ENST00000592784.1_Missense_Mutation_p.K184E|NLRP7_ENST00000590030.1_Missense_Mutation_p.K184E|NLRP7_ENST00000340844.2_Missense_Mutation_p.K184E|NLRP7_ENST00000448121.2_Missense_Mutation_p.K184E|NLRP7_ENST00000446217.1_Missense_Mutation_p.K212E			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	184	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGCGTGGTTTTCCCCACGCCT	0.567000													5	168					0	0	1	0	0
TRAF3	7187	broad.mit.edu	37	14	103372013	103372013	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:103372013C>T	ENST00000560371.1	+	11	1816	c.1599C>T	c.(1597-1599)ggC>ggT	p.G533G	TRAF3_ENST00000392745.2_Silent_p.G533G|TRAF3_ENST00000351691.5_Silent_p.G508G|TRAF3_ENST00000347662.4_Silent_p.G508G|TRAF3_ENST00000539721.1_Silent_p.G450G	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	533	MATH.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		TCGCCTCTGGCTGCCCAGTCT	0.468000													41	144					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156819090	156819090	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156819090A>G	ENST00000368195.3	-	6	1788	c.1392T>C	c.(1390-1392)ggT>ggC	p.G464G	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	464					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGTTCTGCCGACCTCGCGTGC	0.642000													15	104					0	0	1	0	0
CACNG4	27092	broad.mit.edu	37	17	65026608	65026608	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:65026608G>A	ENST00000262138.3	+	4	474	c.472G>A	c.(472-474)Gtc>Atc	p.V158I		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	158					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CGGTATCATCGTCTACATTTC	0.552000													60	165					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1961207	1961207	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:1961207C>T	ENST00000382895.3	+	19	3426	c.2995C>T	c.(2995-2997)Cct>Tct	p.P999S	WHSC1_ENST00000382888.3_Missense_Mutation_p.P347S|WHSC1_ENST00000382891.5_Missense_Mutation_p.P999S|WHSC1_ENST00000382892.2_Missense_Mutation_p.P999S|WHSC1_ENST00000508803.1_Missense_Mutation_p.P999S|WHSC1_ENST00000482415.2_3'UTR	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	999					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGTGAATAAGCCTTACGGGAA	0.512000			T	IGH@	MM								14	66					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126737183	126737183	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:126737183A>G	ENST00000393409.2	+	19	3707	c.3707A>G	c.(3706-3708)tAc>tGc	p.Y1236C	PLXNA1_ENST00000251772.4_Missense_Mutation_p.Y1213C	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1236	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CTGCAGGTGTACTCGGACAGC	0.637000													3	35					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128927038	128927038	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:128927038T>C	ENST00000356892.3	+	7	989	c.875T>C	c.(874-876)cTc>cCc	p.L292P		NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	292	SAM.									breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						GAAACACACCTCAATGAGCTG	0.582000													45	30					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38904532	38904532	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:38904532A>G	ENST00000274276.3	+	9	1614	c.1212A>G	c.(1210-1212)gtA>gtG	p.V404V		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	404	Fibronectin type-III 1.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TGGCGCGAGTACGGTGTGCTG	0.478000													25	77					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144944255	144944255	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144944255T>C	ENST00000525985.1	-	2	3238	c.3167A>G	c.(3166-3168)cAc>cGc	p.H1056R				P58107	EPIPL_HUMAN	epiplakin 1	1056						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGGAGGTGGTGGTGGCTGGT	0.612000													3	38					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604639	140604639	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140604639A>G	ENST00000239449.4	+	1	1562	c.1562A>G	c.(1561-1563)tAc>tGc	p.Y521C	PCDHB14_ENST00000515856.2_Missense_Mutation_p.Y368C	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		521	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGCTGGACTACGAGGCCCTA	0.687000													68	208					0	0	1	0	0
KRTAP9-4	85280	broad.mit.edu	37	17	39406206	39406206	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39406206A>G	ENST00000334109.2	+	1	268	c.234A>G	c.(232-234)acA>acG	p.T78T		NM_033191.2	NP_149461.2	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	78	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament				breast(1)|large_intestine(1)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCTGCAGCACACCCTGCTGCC	0.617000													9	201					0	0	1	0	0
BAG4	9530	broad.mit.edu	37	8	38066679	38066679	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:38066679C>T	ENST00000287322.4	+	4	1053	c.782C>T	c.(781-783)gCg>gTg	p.A261V	BAG4_ENST00000432471.2_Missense_Mutation_p.A225V	NM_004874.3	NP_004865.1	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	261					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|urinary_tract(1)	11	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				CCTTCATCAGCGCCCTCAGCA	0.572000													24	75					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62291660	62291660	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:62291660A>G	ENST00000378024.4	-	5	10503	c.10229T>C	c.(10228-10230)aTt>aCt	p.I3410T	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3410					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGGAGATGAAATACTCAGGAA	0.393000													35	68					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476615	120476615	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:120476615G>A	ENST00000355622.6	+	3	2310	c.2209G>A	c.(2209-2211)Gtg>Atg	p.V737M	TLR4_ENST00000394487.4_Missense_Mutation_p.V697M|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	737	TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GATTGTTGTGGTGTCCCAGCA	0.478000													16	65					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130827178	130827178	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:130827178C>T	ENST00000245255.3	+	2	314	c.42C>T	c.(40-42)cgC>cgT	p.R14R		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	14					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAAGGGCCCGCGGTCAGGAGA	0.527000													11	36					0	0	1	0	0
ZSCAN25	221785	broad.mit.edu	37	7	99217536	99217536	+	Missense_Mutation	SNP	C	C	T	rs145815306	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:99217536C>T	ENST00000394152.2	+	4	634	c.307C>T	c.(307-309)Cgg>Tgg	p.R103W	ZSCAN25_ENST00000262941.6_Missense_Mutation_p.R103W|ZSCAN25_ENST00000466948.1_3'UTR|ZSCAN25_ENST00000334715.3_Missense_Mutation_p.R103W	NM_145115.2	NP_660090.2			zinc finger and SCAN domain containing 25																		CGCCTGGATCCGGGAGCATGG	0.642000													21	54					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116579933	116579933	+	Silent	SNP	G	G	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:116579933G>T	ENST00000369503.4	+	8	1225	c.1095G>T	c.(1093-1095)cgG>cgT	p.R365R	SLC22A15_ENST00000481127.1_3'UTR	NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	365					ion transport	integral to membrane	transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GGTTTGGTCGGAAGCGAACAT	0.343000													40	138					4.16155e-14	4.34957e-14	1	1	0
CHFR	55743	broad.mit.edu	37	12	133438054	133438054	+	Splice_Site	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133438054T>A	ENST00000266880.7	-	7	849	c.787_splice	c.e7+1	p.G262_splice	CHFR_ENST00000432561.2_Splice_Site_p.G262_splice|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000315585.7_Splice_Site_p.G221_splice|CHFR_ENST00000450056.2_Splice_Site_p.G250_splice|CHFR_ENST00000443047.2_Splice_Site_p.G170_splice			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	262					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		GACACTAACCTCCTCTCATTT	0.577000													27	116					0	0	1	0	0
EMP1	2012	broad.mit.edu	37	12	13367596	13367596	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:13367596G>A	ENST00000256951.5	+	5	644	c.445G>A	c.(445-447)Gtt>Att	p.V149I	EMP1_ENST00000542289.1_Intron|EMP1_ENST00000537612.1_Intron|EMP1_ENST00000396301.3_Silent_p.A136A|EMP1_ENST00000544053.1_3'UTR|EMP1_ENST00000431267.2_Missense_Mutation_p.V82I	NM_001423.2	NP_001414.1	P54849	EMP1_HUMAN	epithelial membrane protein 1	149					cell growth|cell proliferation|epidermis development	integral to membrane|membrane fraction							Prostate(47;0.194)		BRCA - Breast invasive adenocarcinoma(232;0.153)		CATCATCGGCGTTCTCTATCT	0.532000													45	70					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17412171	17412171	+	Silent	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:17412171A>G	ENST00000494857.1	+	8	1376	c.1158A>G	c.(1156-1158)acA>acG	p.T386T	SLC7A2_ENST00000522656.1_Silent_p.T386T|SLC7A2_ENST00000398090.3_Intron|SLC7A2_ENST00000004531.10_Silent_p.T426T|SLC7A2_ENST00000470360.1_Intron	NM_001008539.3	NP_001008539.3	P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	386					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	AAACGAAGACACCAATAATTG	0.423000													35	247					0	0	1	0	0
IGF2BP2-AS1	646600	broad.mit.edu	37	3	185431246	185431246	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:185431246C>T	ENST00000296270.1	+	1	167	c.31C>T	c.(31-33)Ccc>Tcc	p.P11S	IGF2BP2_ENST00000346192.3_Intron|IGF2BP2_ENST00000457616.2_Intron|IGF2BP2_ENST00000382199.2_Intron|IGF2BP2_ENST00000421047.2_Intron																		all_cancers(143;1.5e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CTGTCTAAGGCCCTTTCCAGA	0.478000													7	65					0	0	1	0	0
ZNF543	125919	broad.mit.edu	37	19	57839316	57839316	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:57839316T>C	ENST00000321545.4	+	4	831	c.486T>C	c.(484-486)ggT>ggC	p.G162G		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CAGATGATGGTGTATGTACAA	0.443000													5	101					0	0	1	0	0
PPP1R18	170954	broad.mit.edu	37	6	30653575	30653575	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30653575T>A	ENST00000274853.3	-	1	2097	c.221A>T	c.(220-222)gAg>gTg	p.E74V	PPP1R18_ENST00000488324.1_Intron|PPP1R18_ENST00000399199.3_Missense_Mutation_p.E74V	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	74						cytoplasm|cytoskeleton	actin binding										GACCGCAGACTCATCCGGGTC	0.657000													17	63					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41385310	41385310	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:41385310T>C	ENST00000400454.1	-	33	6167	c.5690A>G	c.(5689-5691)gAc>gGc	p.D1897G		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1897				HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATGTATGAGGTCACCTAGAAG	0.488000													6	42					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29912358	29912358	+	Missense_Mutation	SNP	T	T	C	rs45584337		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:29912358T>C	ENST00000396634.1	+	7	1318	c.977T>C	c.(976-978)gTg>gCg	p.V326A	HLA-A_ENST00000376809.5_Missense_Mutation_p.V326A|HLA-A_ENST00000376802.2_Intron|HLA-A_ENST00000376806.5_Missense_Mutation_p.V326A			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	326					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						ACTGGAGCTGTGGTCGCTGCC	0.587000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			24	124					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236912	140236912	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140236912C>T	ENST00000307360.5	+	1	1279	c.1279C>T	c.(1279-1281)Cgg>Tgg	p.R427W	PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.R427W|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGACCGCGCGGGACGGGGG	0.647000													85	235					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80729848	80729848	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:80729848C>T	ENST00000458043.2	+	38	4507	c.4501C>T	c.(4501-4503)Cct>Tct	p.P1501S	OTOGL_ENST00000547103.1_Missense_Mutation_p.P1489S	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CGTGGAAATGCCTGACTGTGG	0.433000													7	62					0	0	1	0	0
WFIKKN1	117166	broad.mit.edu	37	16	683135	683135	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:683135T>C	ENST00000319070.2	+	2	1047	c.725T>C	c.(724-726)gTc>gCc	p.V242A		NM_053284.2	NP_444514.1	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	242	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|prostate(1)|upper_aerodigestive_tract(1)	4		Hepatocellular(780;0.00335)				AACGTGGTGGTCACCAGCATC	0.667000													17	29					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50815236	50815236	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:50815236T>C	ENST00000540145.1	+	10	2013	c.1598T>C	c.(1597-1599)tTt>tCt	p.F533S	CYLD_ENST00000427738.3_Missense_Mutation_p.F533S|CYLD_ENST00000398568.2_Missense_Mutation_p.F530S|CYLD_ENST00000311559.9_Missense_Mutation_p.F533S|CYLD_ENST00000569418.1_Missense_Mutation_p.F530S|CYLD_ENST00000568704.2_Intron|CYLD_ENST00000566206.1_Missense_Mutation_p.F530S|CYLD_ENST00000564326.1_Missense_Mutation_p.F530S			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	533	CAP-Gly 3.|Interaction with IKBKG/NEMO.|Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				AAGGCGCTGTTTGTGAAACTG	0.473000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				22	44					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097313	167097313	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:167097313A>G	ENST00000361200.2	+	6	3111	c.2945A>G	c.(2944-2946)aAa>aGa	p.K982R	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.K982R|DUSP27_ENST00000271385.5_Missense_Mutation_p.K982R			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	982	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AAGTTTTCCAAATCCCAGTCA	0.517000													9	108					0	0	1	0	0
RFPL3	10738	broad.mit.edu	37	22	32756465	32756465	+	Silent	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:32756465T>C	ENST00000249007.4	+	2	805	c.600T>C	c.(598-600)tcT>tcC	p.S200S	RFPL3S_ENST00000382084.4_3'UTR|RFPL3S_ENST00000400234.1_3'UTR|RFPL3_ENST00000382088.3_Silent_p.S171S|RFPL3_ENST00000397468.1_Silent_p.S171S	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	200	B30.2/SPRY.						zinc ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						GCAGAGAATCTGTTCACTGCA	0.577000													32	131					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954387	35954387	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:35954387G>A	ENST00000274278.3	-	7	1846	c.1489C>T	c.(1489-1491)Ctg>Ttg	p.L497L		NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	497						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATAGTGCCCAGAGTGAGCCCC	0.587000													10	46					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49753038	49753038	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49753038A>G	ENST00000327697.6	+	32	3185	c.3041A>G	c.(3040-3042)cAc>cGc	p.H1014R	RNF123_ENST00000433785.1_Missense_Mutation_p.H126R	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	1014						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CTGCAGCAGCACATGGCGGAC	0.607000													16	37					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72211461	72211461	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:72211461G>A	ENST00000340726.3	-	9	1286	c.647C>T	c.(646-648)cCg>cTg	p.P216L	EYA1_ENST00000419131.1_Missense_Mutation_p.P211L|EYA1_ENST00000388741.2_Missense_Mutation_p.P182L|EYA1_ENST00000388740.3_Missense_Mutation_p.P183L|EYA1_ENST00000303824.7_Missense_Mutation_p.P210L|EYA1_ENST00000388742.4_Missense_Mutation_p.P216L|EYA1_ENST00000388743.2_Missense_Mutation_p.P215L	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	216					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GGGATAAGACGGATAGTCCTA	0.423000													17	104					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72227104	72227104	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:72227104A>C	ENST00000269346.4	+	3	454	c.380A>C	c.(379-381)gAt>gCt	p.D127A	TTYH2_ENST00000529107.1_Missense_Mutation_p.D106A	NM_032646.5	NP_116035.5	Q9BSA4	TTYH2_HUMAN	tweety family member 2	127						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						TCCTTGGACGATGCCAACCAC	0.577000													22	80					0	0	1	0	0
PLEKHB1	58473	broad.mit.edu	37	11	73366910	73366910	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:73366910G>A	ENST00000354190.5	+	6	884	c.453G>A	c.(451-453)gtG>gtA	p.V151V	PLEKHB1_ENST00000398492.4_Intron|PLEKHB1_ENST00000535129.1_Intron|PLEKHB1_ENST00000227214.6_Intron|PLEKHB1_ENST00000543085.1_Intron|PLEKHB1_ENST00000398494.4_Silent_p.V132V	NM_021200.2	NP_067023.1	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B (evectins) member 1	151					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	7						TCAGGTGTGTGACCCGCTCGT	0.642000													21	68					0	0	1	0	0
KLHL21	9903	broad.mit.edu	37	1	6659379	6659379	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:6659379G>A	ENST00000377663.3	-	2	1338	c.1155C>T	c.(1153-1155)taC>taT	p.Y385Y	KLHL21_ENST00000467612.1_Silent_p.Y18Y|KLHL21_ENST00000463043.1_Silent_p.Y18Y|KLHL21_ENST00000377658.4_Silent_p.Y385Y			Q9UJP4	KLH21_HUMAN	kelch-like family member 21	385					anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|prostate(2)	8	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		CGGCCACCACGTACAGCAGTC	0.632000													16	66					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47810748	47810748	+	Splice_Site	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:47810748T>C	ENST00000285106.6	-	9	1919	c.1205_splice	c.e9+1	p.N402_splice	CXXC1_ENST00000412036.2_Splice_Site_p.N406_splice|CXXC1_ENST00000589940.1_Splice_Site_p.N402_splice	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	402					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						AATGACTCACTTGGCTGCCAG	0.592000													29	98					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56042676	56042676	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:56042676C>T	ENST00000413299.1	-	3	327	c.290G>A	c.(289-291)cGc>cAc	p.R97H	SBK2_ENST00000344158.3_Missense_Mutation_p.R97H	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	97	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						GAGGGACGTGCGGGGTTTCGG	0.672000													8	27					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164697201	164697201	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:164697201C>T	ENST00000264382.3	-	48	5495	c.5433G>A	c.(5431-5433)ctG>ctA	p.L1811L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1811	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTGTGTGGTCAGATCAATAC	0.284000										HNSCC(35;0.089)			8	71					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102445732	102445732	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:102445732A>G	ENST00000360184.4	+	3	585	c.421A>G	c.(421-423)Agt>Ggt	p.S141G		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	141	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CCTTACACTCAGTGAAGACTC	0.423000													7	141					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8722955	8722955	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:8722955A>G	ENST00000381920.3	+	3	760	c.502A>G	c.(502-504)Atc>Gtc	p.I168V	METTL22_ENST00000561758.1_Missense_Mutation_p.I112V	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	168							methyltransferase activity			large_intestine(5)|lung(4)	9						CCCGCACGATATCATCAGAAT	0.542000													119	363					0	0	1	0	0
TCEA3	6920	broad.mit.edu	37	1	23751109	23751109	+	Silent	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:23751109C>T	ENST00000450454.2	-	1	124	c.18G>A	c.(16-18)gaG>gaA	p.E6E	TCEA3_ENST00000374601.3_Silent_p.E6E	NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	6	TFIIS N-terminal.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TCCTCAGCAGCTCCTCTTCCT	0.721000													22	91					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52881710	52881710	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52881710A>G	ENST00000330722.6	-	9	1557	c.1489T>C	c.(1489-1491)Tat>Cat	p.Y497H		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	497	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCACCGCCATAGCCACTGGAG	0.602000													17	51					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33235683	33235683	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:33235683A>G	ENST00000445902.2	-	9	1110	c.892T>C	c.(892-894)Tct>Cct	p.S298P	VPS52_ENST00000436044.2_Missense_Mutation_p.S173P|VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000478934.1_5'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	298					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						CGGTAGTAAGACAGGTAAATC	0.532000													42	136					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98742051	98742051	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98742051A>G	ENST00000286067.2	+	1	1011	c.904A>G	c.(904-906)Aca>Gca	p.T302A		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	302										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGAGGAAACGACAGCCTCCAG	0.572000													7	94					0	0	1	0	0
SIRT7	51547	broad.mit.edu	37	17	79875959	79875959	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:79875959C>T	ENST00000328666.6	-	1	111	c.49G>A	c.(49-51)Gtc>Atc	p.V17I		NM_016538.2	NP_057622.1	Q9NRC8	SIRT7_HUMAN	sirtuin 7	17	Arg-rich.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			AACCTCCGGACCCGCTCCGCC	0.776000													14	33					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50861878	50861878	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50861878C>G	ENST00000253719.2	-	9	1403	c.1195G>C	c.(1195-1197)Gcg>Ccg	p.A399P	NR1H2_ENST00000600978.1_Intron|NR1H2_ENST00000542413.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	399					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		CGAGCGCGCGCCAGGCCCACC	0.697000													9	20					0	0	1	0	0
ZNF562	54811	broad.mit.edu	37	19	9767279	9767279	+	Translation_Start_Site	SNP	G	G	A	rs151017672	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:9767279G>A	ENST00000537617.1	-	0	360				ZNF562_ENST00000590155.1_Missense_Mutation_p.R98W|ZNF562_ENST00000453792.2_Missense_Mutation_p.R29W|ZNF562_ENST00000293648.4_Missense_Mutation_p.R26W|ZNF562_ENST00000587392.1_Intron|ZNF562_ENST00000453372.2_Missense_Mutation_p.R98W|ZNF562_ENST00000448622.1_Missense_Mutation_p.R98W|ZNF562_ENST00000541032.1_Missense_Mutation_p.R61W			Q6V9R5	ZN562_HUMAN	zinc finger protein 562						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	17						AGTGATGACCGTTTGGTTCTA	0.323000													32	110					0	0	1	0	0
ZDHHC5	25921	broad.mit.edu	37	11	57464277	57464277	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:57464277T>C	ENST00000287169.3	+	10	2416	c.1054T>C	c.(1054-1056)Tac>Cac	p.Y352H	ZDHHC5_ENST00000527985.1_Missense_Mutation_p.Y299H	NM_015457.2	NP_056272.2	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC-type containing 5	352						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(6)|kidney(3)|large_intestine(3)|lung(5)|skin(1)	18						ACCTACCATGTACAAGTATCG	0.502000													13	75					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33878260	33878260	+	Silent	SNP	G	G	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:33878260G>A	ENST00000389232.4	+	16	1801	c.1731G>A	c.(1729-1731)gcG>gcA	p.A577A	RYR3_ENST00000415757.3_Silent_p.A577A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	577					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCTGATAGCGGAGGGCCACA	0.448000													25	61					0	0	1	0	0
CPSF3L	54973	broad.mit.edu	37	1	1247409	1247411	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1247409_1247411delAGG	ENST00000540437.1	-	18	2197_2199	c.1742_1744delCCT	c.(1741-1746)tgg>t	p.SW581del	CPSF3L_ENST00000419704.1_In_Frame_Del_p.SW474del|CPSF3L_ENST00000435064.1_In_Frame_Del_p.SW575del|CPSF3L_ENST00000462432.1_5'UTR|CPSF3L_ENST00000421495.2_In_Frame_Del_p.SW317del|CPSF3L_ENST00000545578.1_In_Frame_Del_p.SW546del|CPSF3L_ENST00000450926.2_In_Frame_Del_p.SW553del|CPSF3L_ENST00000411962.1_In_Frame_Del_p.SW477del	NM_001256456.1	NP_001243385.1	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor 3-like	575						Golgi apparatus|nucleus	hydrolase activity			endometrium(4)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(3)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		TGGTAGGTCCAGGAGACCAGCAG	0.631													3	5	---	---	---	---					
MXRA8	54587	broad.mit.edu	37	1	1290110	1290110	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:1290110delG	ENST00000309212.6	-	5	931	c.901delC	c.(901-903)ggfs	p.R301fs	MXRA8_ENST00000445648.2_Frame_Shift_Del_p.R301fs|MXRA8_ENST00000342753.4_Frame_Shift_Del_p.R200fs	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	301						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGAGAGCCCCGGGGGGGCGGC	0.741													8	19	---	---	---	---					
RPL22	6146	broad.mit.edu	37	1	6257785	6257785	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:6257785delT	ENST00000234875.4	-	2	82	c.44delA	c.(43-45)agfs	p.K16fs	RPL22_ENST00000484532.1_5'UTR|RPL22_ENST00000497965.1_5'UTR	NM_000983.3	NP_000974.1	P35268	RL22_HUMAN	ribosomal protein L22	16					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome	p.K15fs*5(1)		kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AACTTGCTTCTTTTTTTTGCC	0.398			T	RUNX1	"""AML, CML"""								7	38	---	---	---	---					
TNFRSF9	3604	broad.mit.edu	37	1	7998254	7998254	+	Splice_Site	DEL	T	T	-	rs9657965	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:7998254delT	ENST00000377507.3	-	4	511	c.346_splice	c.e4+1	p.K115_splice		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	115			K -> N (in dbSNP:rs9657965).		induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		CAAACGTACCTTTTTTTGTCA	0.413													31	125	---	---	---	---					
SLC25A33	84275	broad.mit.edu	37	1	9627374	9627374	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:9627374delT	ENST00000302692.6	+	3	479	c.269delT	c.(268-270)ctfs	p.L90fs		NM_032315.2	NP_115691.1	Q9BSK2	S2533_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	90					transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|kidney(1)|lung(4)|prostate(1)|skin(1)	9	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CCAAAGTCACTTTTTAGAGGC	0.413													69	204	---	---	---	---					
PIK3CD	5293	broad.mit.edu	37	1	9777114	9777114	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:9777114delC	ENST00000377346.4	+	7	1073	c.878delC	c.(877-879)gcfs	p.A293fs	PIK3CD_ENST00000536656.1_Intron|PIK3CD_ENST00000361110.2_Intron	NM_005026.3	NP_005017.3	O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	293					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		AGCAACCCTGCCCCCCAGGTC	0.617													29	145	---	---	---	---					
EPHA2	1969	broad.mit.edu	37	1	16462199	16462199	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:16462199delG	ENST00000358432.5	-	6	1533	c.1379delC	c.(1378-1380)cgfs	p.P461fs		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	461	Fibronectin type-III 2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding	p.P460fs*33(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTGCTGCGGCGGGGGGATGCT	0.667													32	82	---	---	---	---					
MST1L	11223	broad.mit.edu	37	1	17084500	17084501	+	RNA	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17084500_17084501insC	ENST00000455405.2	-	0	388_389																											GGCTACTGGGACCCGCTGTAGG	0.599													7	178	---	---	---	---					
ARHGEF10L	55160	broad.mit.edu	37	1	17966735	17966735	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:17966735delC	ENST00000361221.3	+	21	2369	c.2210delC	c.(2209-2211)acfs	p.T737fs	ARHGEF10L_ENST00000452522.1_Frame_Shift_Del_p.T698fs|ARHGEF10L_ENST00000167825.4_Frame_Shift_Del_p.T440fs|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000434513.1_Frame_Shift_Del_p.T732fs|ARHGEF10L_ENST00000375415.1_Frame_Shift_Del_p.T698fs|ARHGEF10L_ENST00000375408.3_Frame_Shift_Del_p.T510fs	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	737					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GTTTTCATCACCCCCAACCCC	0.582													8	21	---	---	---	---					
IFNLR1	163702	broad.mit.edu	37	1	24484361	24484362	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:24484361_24484362delGT	ENST00000327535.1	-	7	833_834	c.821_822delAC	c.(820-822)cfs	p.H274fs	IFNLR1_ENST00000374421.3_Intron|IFNLR1_ENST00000327575.2_Frame_Shift_Del_p.TP230fs	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		TTGCCACAGGGTGTGTGTGTCC	0.495													33	133	---	---	---	---					
RHD	6007	broad.mit.edu	37	1	25599124	25599125	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:25599124_25599125insT	ENST00000328664.4	+	1	241_242	c.86_87insT	c.(85-87)tttfs	p.F29fs	RHD_ENST00000454452.2_Frame_Shift_Ins_p.F29fs|RHD_ENST00000423810.2_Frame_Shift_Ins_p.F29fs|RHD_ENST00000417538.2_Frame_Shift_Ins_p.F29fs|RHD_ENST00000342055.5_Frame_Shift_Ins_p.F29fs|RHD_ENST00000357542.4_Frame_Shift_Ins_p.F29fs|RHD_ENST00000423253.1_3'UTR|RHD_ENST00000568195.1_Frame_Shift_Ins_p.F29fs	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	29						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTCCTCTTCTATTTTTTTACCC	0.520													11	221	---	---	---	---					
RHCE	6006	broad.mit.edu	37	1	25747184	25747185	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:25747184_25747185insA	ENST00000294413.7	-	1	151_152	c.93_94insT	c.(91-96)ttcccafs	p.FP31fs	RHCE_ENST00000346452.4_Frame_Shift_Ins_p.FP31fs|RHCE_ENST00000349438.4_Frame_Shift_Ins_p.FP31fs|RHCE_ENST00000455194.1_Frame_Shift_Ins_p.FP31fs|RHCE_ENST00000413854.1_Frame_Shift_Ins_p.FP31fs|RHCE_ENST00000349320.3_Intron|RHCE_ENST00000495048.1_5'UTR|RHCE_ENST00000340849.4_Frame_Shift_Ins_p.FP31fs|RHCE_ENST00000243186.6_Frame_Shift_Ins_p.FP31fs|RHCE_ENST00000425135.1_Frame_Shift_Ins_p.FP31fs	NM_020485.4	NP_065231.3	P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	31						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		TCATAGTGGGTAAAAAAATAGA	0.535													28	98	---	---	---	---					
SLC9A1	6548	broad.mit.edu	37	1	27426906	27426906	+	Frame_Shift_Del	DEL	G	G	-	rs147891871		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:27426906delG	ENST00000263980.3	-	12	2915	c.2340delC	c.(2338-2340)ccfs	p.P780fs	SLC9A1_ENST00000545949.1_Frame_Shift_Del_p.P441fs	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	780					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	CACTGGGCGCGGGGGTGAAGA	0.637													31	131	---	---	---	---					
TMEM39B	55116	broad.mit.edu	37	1	32568241	32568241	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:32568241delC	ENST00000336294.5	+	9	1592	c.1446delC	c.(1444-1446)agfs	p.S482fs	TMEM39B_ENST00000373634.4_Frame_Shift_Del_p.S283fs|TMEM39B_ENST00000487305.1_3'UTR	NM_018056.2	NP_060526.2	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	482						integral to membrane				endometrium(2)|kidney(1)|lung(5)|ovary(1)|prostate(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				ACTCTGCTAGCCCCCAGAGAG	0.607													22	88	---	---	---	---					
KIAA1522	57648	broad.mit.edu	37	1	33233495	33233495	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:33233495delC	ENST00000401073.2	+	2	413	c.343delC	c.(343-345)ccfs	p.P116fs	KIAA1522_ENST00000373481.3_Frame_Shift_Del_p.P68fs|KIAA1522_ENST00000294521.3_Frame_Shift_Del_p.P57fs|KIAA1522_ENST00000373480.1_Frame_Shift_Del_p.P57fs	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	57										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CAGTGGGCGACCCCCCCACCT	0.612													74	82	---	---	---	---					
DLGAP3	58512	broad.mit.edu	37	1	35370731	35370732	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:35370731_35370732delCC	ENST00000373347.1	-	3	521_522	c.253_254delGG	c.(253-255)tfs	p.G85fs	DLGAP3_ENST00000235180.4_Frame_Shift_Del_p.G85fs			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	85					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GGTGCTGCTACCCCCCCCAACC	0.698													3	6	---	---	---	---					
ZFP69	339559	broad.mit.edu	37	1	40954809	40954809	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:40954809delG	ENST00000372706.1	+	4	1275	c.269delG	c.(268-270)tgfs	p.W90fs	ZFP69_ENST00000372705.3_Frame_Shift_Del_p.W90fs					ZFP69 zinc finger protein																		CAGGAAGAGTGGGGGCAGCTG	0.458													27	83	---	---	---	---					
PTCH2	8643	broad.mit.edu	37	1	45288255	45288257	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:45288255_45288257delGGA	ENST00000372192.3	-	22	3572_3574	c.3442_3444delTCC	c.(3442-3444)del	p.S1148del	PTCH2_ENST00000447098.2_Intron	NM_003738.4	NP_003729.3	Q9Y6C5	PTC2_HUMAN	patched 2	1148					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					TCTGGGGCAGGGAGGAGGATGCC	0.626									Basal Cell Nevus syndrome				38	130	---	---	---	---					
CYP4Z2P	163720	broad.mit.edu	37	1	47339125	47339125	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:47339125delC	ENST00000505841.1	-	0	775					NR_002788.2																						CCCCCTGGCACCCCCCCCATG	0.443													4	9	---	---	---	---					
FGGY	55277	broad.mit.edu	37	1	59812017	59812017	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:59812017delG	ENST00000371218.4	+	4	596	c.412delG	c.(412-414)ggfs	p.G139fs	FGGY_ENST00000371212.1_Intron|FGGY_ENST00000474476.1_3'UTR|FGGY_ENST00000303721.7_Frame_Shift_Del_p.G139fs	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	139					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					CCAGTACGTCGGGGGGGTGAT	0.502													14	68	---	---	---	---					
INADL	10207	broad.mit.edu	37	1	62267407	62267407	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:62267407delA	ENST00000371158.2	+	12	1629	c.1515delA	c.(1513-1515)ttfs	p.L505fs	INADL_ENST00000316485.6_Frame_Shift_Del_p.L505fs	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	505					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTGATACTTTAAAAAATGACA	0.353													23	88	---	---	---	---					
MIER1	57708	broad.mit.edu	37	1	67452114	67452114	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:67452114delT	ENST00000371018.3	+	16	1687	c.1371delT	c.(1369-1371)cafs	p.H457fs	MIER1_ENST00000355356.3_3'UTR|MIER1_ENST00000371016.1_Frame_Shift_Del_p.H437fs|MIER1_ENST00000401042.3_Frame_Shift_Del_p.H420fs|MIER1_ENST00000371014.1_Frame_Shift_Del_p.H473fs|MIER1_ENST00000357692.2_3'UTR|MIER1_ENST00000355977.6_Frame_Shift_Del_p.H357fs	NM_001077702.2|NM_001146111.1|NM_001146112.1|NM_020948.3	NP_001071170.2|NP_001139583.1|NP_001139584.1|NP_065999.2	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	0					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						TTCCAGTTCATTTTTCAGCCA	0.328													28	89	---	---	---	---					
ASB17	127247	broad.mit.edu	37	1	76387916	76387916	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:76387916delT	ENST00000284142.6	-	2	669	c.530delA	c.(529-531)acfs	p.N177fs		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	177					intracellular signal transduction			p.N177fs*21(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						GTTGATAGGGTTTTTTTCTCT	0.368													16	27	---	---	---	---					
IFI44L	10964	broad.mit.edu	37	1	79095512	79095513	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:79095512_79095513insT	ENST00000370751.4	+	4	814_815	c.635_636insT	c.(634-636)attfs	p.I212fs	IFI44L_ENST00000476521.1_3'UTR|IFI44L_ENST00000342282.3_5'UTR	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	212						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						GGAAAGTCCAGTTTTTTCAATT	0.450													16	64	---	---	---	---					
RPAP2	79871	broad.mit.edu	37	1	92846371	92846371	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:92846371delA	ENST00000370343.3	+	12	1888	c.1779delA	c.(1777-1779)ctfs	p.L593fs		NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	593						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		AATTACATCTAAAAAATGAAG	0.363													27	89	---	---	---	---					
RP11-435B5.5	0	broad.mit.edu	37	1	143391935	143391936	+	RNA	INS	-	-	TG			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:143391935_143391936insTG	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							ATATATATATATAAAGAGATTG	0.252													5	6	---	---	---	---					
CREB3L4	148327	broad.mit.edu	37	1	153941609	153941609	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:153941609delG	ENST00000368607.3	+	3	644	c.378delG	c.(376-378)cafs	p.Q126fs	CREB3L4_ENST00000405694.3_Intron|CREB3L4_ENST00000368601.1_Frame_Shift_Del_p.Q126fs|CREB3L4_ENST00000368600.3_Frame_Shift_Del_p.Q106fs|CREB3L4_ENST00000368603.1_Frame_Shift_Del_p.Q126fs|CREB3L4_ENST00000271889.4_Frame_Shift_Del_p.Q126fs	NM_001255978.1|NM_001255980.1|NM_130898.3	NP_001242907.1|NP_001242909.1|NP_570968.1	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like 4	126					response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(3)	13	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGAGGATGCAGGGGGAAACTG	0.587													44	176	---	---	---	---					
KIAA0907	22889	broad.mit.edu	37	1	155884009	155884009	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:155884009delT	ENST00000368321.3	-	14	1771	c.1748delA	c.(1747-1749)atfs	p.N583fs	KIAA0907_ENST00000368320.3_3'UTR	NM_014949.2	NP_055764.2	Q7Z7F0	K0907_HUMAN	KIAA0907	583										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			ACTACTTGCATTTTTATGACC	0.448													27	99	---	---	---	---					
PRCC	5546	broad.mit.edu	37	1	156761536	156761536	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:156761536delC	ENST00000271526.4	+	4	1403	c.1131delC	c.(1129-1131)gtfs	p.V377fs	PRCC_ENST00000491853.1_3'UTR|PRCC_ENST00000353233.3_Intron	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	377					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding	p.Q380fs*12(1)	PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CGGCCCTGGTCCCCCCCCAGG	0.527			T	TFE3	papillary renal								26	105	---	---	---	---					
CADM3	57863	broad.mit.edu	37	1	159166185	159166186	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:159166185_159166186insC	ENST00000368125.4	+	6	880_881	c.723_724insC	c.(721-726)cccccafs	p.PP241fs	CADM3_ENST00000368124.4_Frame_Shift_Ins_p.PP275fs|CTA-134P22.2_ENST00000415675.2_RNA	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	241	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					GGCCAGACCCTCCCCATCCTCG	0.520											OREG0013913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	49	---	---	---	---					
CCDC181	57821	broad.mit.edu	37	1	169366580	169366580	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:169366580delT	ENST00000545005.1	-	6	1769	c.1262delA	c.(1261-1263)agfs	p.K421fs	CCDC181_ENST00000367805.3_Frame_Shift_Del_p.K421fs|CCDC181_ENST00000367806.3_Frame_Shift_Del_p.K422fs					coiled-coil domain containing 181																		CTCTTCGTGCTTTTTTTTAAG	0.363													8	35	---	---	---	---					
CAMSAP2	23271	broad.mit.edu	37	1	200827020	200827020	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:200827020delA	ENST00000358823.2	+	17	4540	c.4270delA	c.(4270-4272)aafs	p.K1425fs	CAMSAP2_ENST00000413307.2_Frame_Shift_Del_p.K1409fs|CAMSAP2_ENST00000236925.4_Frame_Shift_Del_p.K1436fs	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	1436	CKK.					cytoplasm|microtubule	protein binding										ATCTATCACTAAAAAAATGAT	0.373													27	95	---	---	---	---					
CENPF	1063	broad.mit.edu	37	1	214830564	214830564	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:214830564delA	ENST00000366955.3	+	18	8942	c.8774delA	c.(8773-8775)cafs	p.Q2925fs		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	3021	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TCATCTGGCCAAAATAAAGCT	0.453													33	109	---	---	---	---					
TP53BP2	7159	broad.mit.edu	37	1	224001956	224001956	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:224001956delG	ENST00000343537.7	-	3	566	c.275delC	c.(274-276)ctfs	p.P92fs	TP53BP2_ENST00000391878.2_5'UTR	NM_001031685.2	NP_001026855.2	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	86					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		GTCCCTGCCAGGGGGGCGTTC	0.473													27	92	---	---	---	---					
CCSAP	126731	broad.mit.edu	37	1	229478194	229478194	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:229478194delC	ENST00000284617.2	-	2	143	c.19delG	c.(19-21)tgfs	p.V7fs	CCSAP_ENST00000452552.1_Frame_Shift_Del_p.V7fs|CCSAP_ENST00000366687.1_Frame_Shift_Del_p.V7fs|CCSAP_ENST00000483092.1_5'UTR	NM_145257.3	NP_660300.3			centriole, cilia and spindle-associated protein																		TCGCTCTTCACCCCGCTCCCC	0.721													12	35	---	---	---	---					
FMN2	56776	broad.mit.edu	37	1	240371608	240371608	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:240371608delC	ENST00000319653.9	+	5	3726	c.3496delC	c.(3496-3498)ccfs	p.P1167fs		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1167	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCCCCACCTCCCCCTCTACC	0.692													9	20	---	---	---	---					
OR2W3	343171	broad.mit.edu	37	1	248059733	248059733	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr1:248059733delC	ENST00000537741.1	+	3	1102	c.845delC	c.(844-846)acfs	p.T282fs	OR2W3_ENST00000360358.3_Frame_Shift_Del_p.T282fs			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L284fs*14(1)		breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AACATTGTCACCCCCCTCCTC	0.507													23	80	---	---	---	---					
ASAP2	8853	broad.mit.edu	37	2	9528643	9528643	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:9528643delC	ENST00000281419.3	+	22	2691	c.2351delC	c.(2350-2352)gcfs	p.A784fs	ASAP2_ENST00000315273.4_Frame_Shift_Del_p.A784fs|ASAP2_ENST00000491413.1_3'UTR	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	784	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						ACCACCAGCGCCCCCCCGCTT	0.577													22	56	---	---	---	---					
EMILIN1	11117	broad.mit.edu	37	2	27303108	27303108	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:27303108delG	ENST00000380320.4	+	2	759	c.260delG	c.(259-261)tgfs	p.W87fs		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	87	EMI.				cell adhesion	collagen				breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTGTGCCTGGGGCCAGCCC	0.612													57	175	---	---	---	---					
C2orf71	388939	broad.mit.edu	37	2	29294162	29294162	+	Frame_Shift_Del	DEL	G	G	-	rs113376827		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:29294162delG	ENST00000331664.5	-	1	2965	c.2966delC	c.(2965-2967)ctfs	p.P989fs		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	989					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TCTGCCCACAGGGGGGCTTCT	0.637													30	58	---	---	---	---					
RASGRP3	25780	broad.mit.edu	37	2	33752314	33752315	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:33752314_33752315insA	ENST00000403687.3	+	10	1658_1659	c.918_919insA	c.(916-921)ttaagafs	p.R307fs	RASGRP3_ENST00000407811.1_Frame_Shift_Ins_p.R307fs|RASGRP3_ENST00000402538.3_Frame_Shift_Ins_p.R307fs	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	307	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					GAGTACACTTGAAAGACTTGAT	0.470													14	50	---	---	---	---					
FOXN2	3344	broad.mit.edu	37	2	48600444	48600446	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:48600444_48600446delTGC	ENST00000340553.3	+	6	978_980	c.717_719delTGC	c.(715-720)gat>ga	p.DA239del		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	239					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			CTGATATTGATGCTGCTGCTGCA	0.305													15	108	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58688842	58688843	+	RNA	DEL	CT	CT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:58688842_58688843delCT	ENST00000452840.1	+	0	127																											TCTCTGCTAGCTCTCTCTCTCT	0.465													11	54	---	---	---	---					
OTX1	5013	broad.mit.edu	37	2	63282711	63282713	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:63282711_63282713delAAG	ENST00000366671.3	+	5	601_603	c.325_327delAAG	c.(325-327)del	p.K111del	OTX1_ENST00000282549.2_In_Frame_Del_p.K111del	NM_001199770.1	NP_001186699.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	111						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					CCGCCCAGCCAAGAAGAAGTCCT	0.655													22	82	---	---	---	---					
ZNF638	27332	broad.mit.edu	37	2	71650549	71650549	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:71650549delA	ENST00000409544.1	+	22	4535	c.3905delA	c.(3904-3906)gafs	p.E1302fs	ZNF638_ENST00000409407.1_Frame_Shift_Del_p.E242fs|ZNF638_ENST00000355812.3_Intron|ZNF638_ENST00000264447.4_Frame_Shift_Del_p.E1302fs	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1302	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AATATTTCTGAAAAAAAAGGT	0.368													11	48	---	---	---	---					
UNC50	25972	broad.mit.edu	37	2	99232795	99232795	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99232795delT	ENST00000409975.1	+	3	1708	c.578delT	c.(577-579)ctfs	p.L193fs	UNC50_ENST00000409347.1_Frame_Shift_Del_p.L193fs|UNC50_ENST00000357765.2_Frame_Shift_Del_p.L176fs			Q53HI1	UNC50_HUMAN	unc-50 homolog (C. elegans)	176					protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding			breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)	10						TTTATCCAGCTTTTTTTCATC	0.408													10	151	---	---	---	---					
MGAT4A	11320	broad.mit.edu	37	2	99242041	99242041	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:99242041delT	ENST00000393487.1	-	16	1909	c.1596delA	c.(1594-1596)aafs	p.K532fs	MGAT4A_ENST00000264968.2_Frame_Shift_Del_p.K532fs|MGAT4A_ENST00000409391.1_Frame_Shift_Del_p.K532fs|MGAT4A_ENST00000414521.2_Intron	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	532					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						AGTTGGTGGCTTTTTTAATAT	0.254													10	63	---	---	---	---					
MRPS9	64965	broad.mit.edu	37	2	105705511	105705512	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:105705511_105705512insA	ENST00000258455.3	+	6	669_670	c.559_560insA	c.(559-561)aaafs	p.K187fs		NM_182640.2	NP_872578.1	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9	187					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						TCTGCTCCCAGAAAAAACTGTA	0.317													17	61	---	---	---	---					
GCC2	9648	broad.mit.edu	37	2	109086477	109086477	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:109086477delA	ENST00000309863.6	+	6	1406	c.692delA	c.(691-693)cafs	p.Q231fs	GCC2_ENST00000485546.1_3'UTR	NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	231					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						CAGCATTACCAAAAAAATATT	0.353													35	150	---	---	---	---					
POLR1B	84172	broad.mit.edu	37	2	113332545	113332545	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:113332545delT	ENST00000263331.5	+	15	3227	c.2647delT	c.(2647-2649)ttfs	p.F883fs	POLR1B_ENST00000417433.2_Frame_Shift_Del_p.F827fs|POLR1B_ENST00000541869.1_Frame_Shift_Del_p.F921fs|POLR1B_ENST00000409894.3_Frame_Shift_Del_p.F700fs|POLR1B_ENST00000537335.1_Frame_Shift_Del_p.F672fs	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	883					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						CGGAGATAAATTTGCCAGTCG	0.473													45	144	---	---	---	---					
LOC101928553	101928553	broad.mit.edu	37	2	149627550	149627550	+	RNA	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:149627550delT	ENST00000601658.1	-	0	676																											cctttgcccattttttTTTAA	0.328													7	18	---	---	---	---					
NEB	4703	broad.mit.edu	37	2	152466344	152466345	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:152466344_152466345insT	ENST00000427231.2	-	81	12510_12511	c.12308_12309insA	c.(12307-12309)agcfs	p.S4103fs	NEB_ENST00000397345.3_Frame_Shift_Ins_p.S4103fs|NEB_ENST00000409198.1_Frame_Shift_Ins_p.S3860fs|NEB_ENST00000603639.1_Frame_Shift_Ins_p.S4103fs|NEB_ENST00000604864.1_Frame_Shift_Ins_p.S4103fs|NEB_ENST00000172853.10_Frame_Shift_Ins_p.S3860fs	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	4102					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGTCATAGGCCTTTTTTGCTTG	0.446													47	148	---	---	---	---					
NEB	4703	broad.mit.edu	37	2	152467061	152467062	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:152467061_152467062insT	ENST00000427231.2	-	80	12188_12189	c.11986_11987insA	c.(11986-11988)tgcfs	p.C3996fs	NEB_ENST00000397345.3_Frame_Shift_Ins_p.C3996fs|NEB_ENST00000409198.1_Frame_Shift_Ins_p.C3753fs|NEB_ENST00000603639.1_Frame_Shift_Ins_p.C3996fs|NEB_ENST00000604864.1_Frame_Shift_Ins_p.C3996fs|NEB_ENST00000172853.10_Frame_Shift_Ins_p.C3753fs	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3995					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGCCTTGGCACTTTTGATGGAA	0.490													61	177	---	---	---	---					
SLC4A10	57282	broad.mit.edu	37	2	162751202	162751202	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:162751202delT	ENST00000375514.5	+	11	1438	c.1151delT	c.(1150-1152)gtfs	p.V384fs	SLC4A10_ENST00000446997.1_Frame_Shift_Del_p.V403fs|SLC4A10_ENST00000272716.5_Frame_Shift_Del_p.V373fs|SLC4A10_ENST00000421911.1_Frame_Shift_Del_p.V403fs|SLC4A10_ENST00000415876.2_Frame_Shift_Del_p.V373fs|SLC4A10_ENST00000535165.1_Frame_Shift_Del_p.L374fs|SLC4A10_ENST00000493021.1_3'UTR	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	403					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTTCATGATGTTGCCTATAAA	0.318													15	23	---	---	---	---					
DYNC1I2	1781	broad.mit.edu	37	2	172549339	172549339	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:172549339delA	ENST00000534253.2	+	3	329	c.161delA	c.(160-162)gafs	p.E54fs	DYNC1I2_ENST00000508530.1_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000409197.1_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000409773.1_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000409453.1_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000409317.1_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000397119.3_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000358002.6_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000340296.4_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000263811.4_Frame_Shift_Del_p.E54fs|DYNC1I2_ENST00000410079.3_Frame_Shift_Del_p.E54fs			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	54					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity	p.R57fs*13(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			TCAGATCTTGAAAAAAAAAGG	0.353													8	31	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179486344	179486346	+	In_Frame_Del	DEL	CTC	CTC	-	rs114331773	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:179486344_179486346delCTC	ENST00000589042.1	-	245	45429_45431	c.45205_45207delGAG	c.(45205-45207)del	p.E15069del	TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_In_Frame_Del_p.E6196del|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_In_Frame_Del_p.E6129del|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_In_Frame_Del_p.E12501del|TTN_ENST00000591111.1_In_Frame_Del_p.E13428del|TTN_ENST00000460472.2_In_Frame_Del_p.E6004del	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13428	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAATGATCTCCTCATCCCCT	0.424													20	84	---	---	---	---					
ITGAV	3685	broad.mit.edu	37	2	187521085	187521085	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:187521085delG	ENST00000261023.3	+	17	1950	c.1676delG	c.(1675-1677)agfs	p.R559fs	AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000374907.3_Frame_Shift_Del_p.R523fs|ITGAV_ENST00000433736.2_Frame_Shift_Del_p.R513fs	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	559					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ACTATTTCAAGGGGGGGACTG	0.428													63	207	---	---	---	---					
BZW1	9689	broad.mit.edu	37	2	201683504	201683505	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:201683504_201683505insA	ENST00000409600.1	+	9	1301_1302	c.846_847insA	c.(844-849)ataaaafs	p.IK282fs	BZW1_ENST00000452790.2_Frame_Shift_Ins_p.IK314fs|BZW1_ENST00000409226.1_Frame_Shift_Ins_p.IK286fs	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	282	W2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						AGGAGGAGATGAAAAAAAACAA	0.371													15	57	---	---	---	---					
CASP8	841	broad.mit.edu	37	2	202151254	202151254	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:202151254delG	ENST00000358485.4	+	9	1750	c.1554delG	c.(1552-1554)atfs	p.M518fs	CASP8_ENST00000323492.7_Frame_Shift_Del_p.M444fs|CASP8_ENST00000432109.2_Frame_Shift_Del_p.M459fs|CASP8_ENST00000264275.5_Frame_Shift_Del_p.M476fs|CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000264274.9_Frame_Shift_Del_p.M375fs	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	459					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding	p.K520fs*19(1)|p.K478fs*19(1)		breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						AGAAAAACATGGGGAAACAGA	0.358										HNSCC(4;0.00038)			13	89	---	---	---	---					
TRAK2	66008	broad.mit.edu	37	2	202264170	202264171	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:202264170_202264171delAA	ENST00000332624.3	-	5	837_838	c.409_410delTT	c.(409-411)afs	p.L137fs	TRAK2_ENST00000430254.1_Frame_Shift_Del_p.L137fs	NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	137						early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						GTTCCGCTTTAAGAGAGCTTGT	0.426													33	75	---	---	---	---					
TNS1	7145	broad.mit.edu	37	2	218696257	218696258	+	Frame_Shift_Ins	INS	-	-	G	rs146820371		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:218696257_218696258insG	ENST00000171887.4	-	20	3370_3371	c.2918_2919insC	c.(2917-2919)cggfs	p.R973fs	TNS1_ENST00000430930.1_Frame_Shift_Ins_p.R973fs|TNS1_ENST00000419504.1_Frame_Shift_Ins_p.R973fs	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	973						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGCCAGACCCGGGGGGGACCG	0.634													8	22	---	---	---	---					
SPEG	10290	broad.mit.edu	37	2	220315987	220315988	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:220315987_220315988insC	ENST00000312358.7	+	5	2375_2376	c.2243_2244insC	c.(2242-2244)accfs	p.T748fs	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000396698.1_Frame_Shift_Ins_p.T644fs|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	748	Ig-like 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ATCACTGCCAACCCCCCGCCCC	0.629													26	101	---	---	---	---					
DIS3L2	129563	broad.mit.edu	37	2	233194612	233194613	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:233194612_233194613insC	ENST00000325385.7	+	15	2105_2106	c.1829_1830insC	c.(1828-1830)cccfs	p.P610fs	DIS3L2_ENST00000273009.6_Intron|DIS3L2_ENST00000409307.1_Frame_Shift_Ins_p.P610fs	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	610							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CTGCGCCGGCACCCCCCGCCCC	0.644													12	52	---	---	---	---					
ARL4C	10123	broad.mit.edu	37	2	235404658	235404660	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:235404658_235404660delCTT	ENST00000390645.2	-	1	1037_1039	c.571_573delAAG	c.(571-573)del	p.K191del	ARL4C_ENST00000339728.3_In_Frame_Del_p.K191del	NM_005737.3	NP_005728.2	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	191					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			endometrium(1)|ovary(1)|skin(1)|urinary_tract(1)	4		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		CGCATTACCGCTTCTTCTTCTGC	0.581													16	64	---	---	---	---					
NDUFA10	4705	broad.mit.edu	37	2	240954220	240954221	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:240954220_240954221insG	ENST00000252711.2	-	5	704_705	c.604_605insC	c.(604-606)cctfs	p.P202fs	NDUFA10_ENST00000404554.1_Frame_Shift_Ins_p.P202fs|NDUFA10_ENST00000307300.4_Frame_Shift_Ins_p.P242fs	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	202					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AATCACCAGGTGGGGGGGCAGG	0.535													23	137	---	---	---	---					
ING5	84289	broad.mit.edu	37	2	242650899	242650899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr2:242650899delA	ENST00000313552.6	+	4	410	c.384delA	c.(382-384)ttfs	p.L128fs	ING5_ENST00000482774.1_3'UTR|ING5_ENST00000406941.1_Frame_Shift_Del_p.L128fs	NM_032329.4	NP_115705.2	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	128					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			large_intestine(1)|lung(1)|skin(1)	3		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		GGCGAGGGTTAAAAAGCAAGT	0.398													27	99	---	---	---	---					
SRGAP3	9901	broad.mit.edu	37	3	9034600	9034600	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:9034600delC	ENST00000383836.3	-	20	2975	c.2548delG	c.(2548-2550)tgfs	p.V850fs	SRGAP3_ENST00000360413.3_Frame_Shift_Del_p.V826fs	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	850					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CGGCCCATCACCCCCCCAAAG	0.557			T	RAF1	pilocytic astrocytoma								7	167	---	---	---	---					
LRRC2	79442	broad.mit.edu	37	3	46580564	46580564	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:46580564delT	ENST00000395905.3	-	4	853	c.461delA	c.(460-462)acfs	p.N154fs	LRRC2_ENST00000296144.3_Frame_Shift_Del_p.N154fs	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	154										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		TGAGATTTGGTTTTTTGGCAG	0.438													19	72	---	---	---	---					
C3orf62	375341	broad.mit.edu	37	3	49314249	49314251	+	In_Frame_Del	DEL	TCT	TCT	-	rs145714914	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49314249_49314251delTCT	ENST00000343010.3	-	1	1091_1093	c.55_57delAGA	c.(55-57)del	p.R19del		NM_198562.2	NP_940964.1	Q6ZUJ4	CC062_HUMAN	chromosome 3 open reading frame 62	19										breast(1)|kidney(1)|large_intestine(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCTTTCTGCATCTTCTTAGTTTT	0.468													18	51	---	---	---	---					
APEH	327	broad.mit.edu	37	3	49719325	49719325	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:49719325delC	ENST00000296456.5	+	17	1928	c.1528delC	c.(1528-1530)ccfs	p.P510fs	APEH_ENST00000438011.1_Frame_Shift_Del_p.P510fs	NM_001640.3	NP_001631.3	P13798	ACPH_HUMAN	acylaminoacyl-peptide hydrolase	510					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGCAGGGGGGCCCCATTCATC	0.602													43	170	---	---	---	---					
RBM6	10180	broad.mit.edu	37	3	50005145	50005145	+	Frame_Shift_Del	DEL	G	G	-	rs141234052		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:50005145delG	ENST00000266022.4	+	3	546	c.287delG	c.(286-288)agfs	p.R96fs	RBM6_ENST00000443081.1_5'UTR|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000441115.1_Intron|RBM6_ENST00000539992.1_Intron|RBM6_ENST00000422955.1_Intron	NM_005777.2	NP_005768.1	P78332	RBM6_HUMAN	RNA binding motif protein 6	96					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CATGATTTCAGGGGGGGAGAT	0.493													52	151	---	---	---	---					
DOCK3	1795	broad.mit.edu	37	3	51417604	51417604	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:51417604delC	ENST00000266037.9	+	52	5572	c.5549delC	c.(5548-5550)acfs	p.T1850fs		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1850						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.P1852fs*45(1)		breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CTGGGTGATACCCCCCCAGCC	0.597													22	81	---	---	---	---					
GRM2	2912	broad.mit.edu	37	3	51743196	51743196	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:51743196delT	ENST00000395052.3	+	2	431	c.197delT	c.(196-198)ctfs	p.L66fs	GRM2_ENST00000442933.2_Frame_Shift_Del_p.L66fs|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	66					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GAGGCCATGCTTTTTGCACTG	0.637													49	145	---	---	---	---					
STAB1	23166	broad.mit.edu	37	3	52547908	52547908	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:52547908delC	ENST00000321725.6	+	32	3434	c.3358delC	c.(3358-3360)ccfs	p.P1121fs		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1121					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.R1122fs*37(1)		breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGTCTTACTGCCCCCCCGAGG	0.622													78	257	---	---	---	---					
IL17RB	55540	broad.mit.edu	37	3	53889347	53889347	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:53889347delA	ENST00000288167.3	+	6	517	c.508delA	c.(508-510)aafs	p.K172fs		NM_018725.3	NP_061195.2	Q9NRM6	I17RB_HUMAN	interleukin 17 receptor B	172					defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		AATGAAATATAAAAAAAAGTG	0.383													7	21	---	---	---	---					
ADAMTS9	56999	broad.mit.edu	37	3	64633651	64633652	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:64633651_64633652delGT	ENST00000498707.1	-	11	2016_2017	c.1674_1675delAC	c.(1672-1677)acccfs	p.TP558fs	ADAMTS9_ENST00000295903.4_Frame_Shift_Del_p.TP530fs	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	558	Disintegrin.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCGGCCCAGGGTGTGTGCTGAG	0.510													47	163	---	---	---	---					
OR5H15	403274	broad.mit.edu	37	3	97887844	97887844	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:97887844delT	ENST00000356526.2	+	1	301	c.301delT	c.(301-303)ttfs	p.F102fs		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CAAGATACAATTTTTTTCCAT	0.383													8	232	---	---	---	---					
OR5H6	79295	broad.mit.edu	37	3	97983477	97983477	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:97983477delT	ENST00000383696.2	+	1	390	c.349delT	c.(349-351)ttfs	p.F118fs	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CATGGTACAATTTTTTTCCCT	0.393													52	162	---	---	---	---					
CD96	10225	broad.mit.edu	37	3	111197863	111197868	+	RNA	DEL	CACACA	CACACA	-	rs71968470		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:111197863_111197868delCACACA	ENST00000497896.1	-	0	208																											CGAACAGCCTcacacacacacacaca	0.544													3	5	---	---	---	---					
ZBTB20	26137	broad.mit.edu	37	3	114058003	114058003	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:114058003delG	ENST00000462705.1	-	12	2677	c.1856delC	c.(1855-1857)ctfs	p.P619fs	ZBTB20_ENST00000357258.3_Frame_Shift_Del_p.P619fs|ZBTB20_ENST00000464560.1_Frame_Shift_Del_p.P619fs|ZBTB20_ENST00000474710.1_Frame_Shift_Del_p.P692fs|ZBTB20_ENST00000481632.1_Frame_Shift_Del_p.P619fs|ZBTB20_ENST00000393785.2_Frame_Shift_Del_p.P619fs|ZBTB20_ENST00000471418.1_Frame_Shift_Del_p.P619fs	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P619fs*43(1)		breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGTGCCTGCAGGGGGGGTCCC	0.632													28	95	---	---	---	---					
COL6A6	131873	broad.mit.edu	37	3	130318620	130318621	+	Frame_Shift_Ins	INS	-	-	C	rs112135798		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:130318620_130318621insC	ENST00000358511.6	+	19	4650_4651	c.4619_4620insC	c.(4618-4620)gccfs	p.A1540fs	COL6A6_ENST00000453409.2_Frame_Shift_Ins_p.A1540fs	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1540	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGCTGGCCAGGCCCCCCCGGGA	0.500													13	45	---	---	---	---					
DNAJC13	23317	broad.mit.edu	37	3	132209834	132209834	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:132209834delT	ENST00000260818.6	+	32	3810	c.3562delT	c.(3562-3564)ttfs	p.F1188fs		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1188							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						ACCTGAAAAGTTTTCTGAGAT	0.323													12	52	---	---	---	---					
PBX2P1	5088	broad.mit.edu	37	3	142895155	142895155	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:142895155delC	ENST00000560287.1	+	0	29																											GGCCTCAGGGCCCCCCCCCAG	0.746													4	7	---	---	---	---					
PLCH1	23007	broad.mit.edu	37	3	155199125	155199125	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:155199125delG	ENST00000460012.1	-	23	4957	c.4600delC	c.(4600-4602)ggfs	p.R1534fs	PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000414191.1_Frame_Shift_Del_p.R1534fs|PLCH1_ENST00000340059.7_Frame_Shift_Del_p.R1572fs|PLCH1_ENST00000334686.6_Frame_Shift_Del_p.R1534fs|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1572					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			ACCAGTGCCCGGGGGAGCTGA	0.512													20	92	---	---	---	---					
NLGN1	22871	broad.mit.edu	37	3	173525572	173525573	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:173525572_173525573insT	ENST00000457714.1	+	4	1025_1026	c.596_597insT	c.(595-597)atafs	p.I199fs	NLGN1_ENST00000401917.3_Frame_Shift_Ins_p.I239fs|NLGN1_ENST00000545397.1_Frame_Shift_Ins_p.I199fs|NLGN1_ENST00000361589.4_Frame_Shift_Ins_p.I199fs	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	216					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTCTTGGCAAGTTATGGCAATG	0.426													19	91	---	---	---	---					
YEATS2	55689	broad.mit.edu	37	3	183521949	183521949	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:183521949delG	ENST00000305135.5	+	27	3952	c.3757delG	c.(3757-3759)tgfs	p.V1253fs		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1253					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding	p.V1253M(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CATCGAGGACGTGCTGACCCA	0.612													42	147	---	---	---	---					
CPN2	1370	broad.mit.edu	37	3	194062731	194062731	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:194062731delG	ENST00000323830.3	-	2	790	c.701delC	c.(700-702)ctfs	p.P234fs	CPN2_ENST00000429275.1_Frame_Shift_Del_p.P234fs	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	234					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GAACACCTGAGGGGGCAGCTC	0.602													16	56	---	---	---	---					
LINC00969	440993	broad.mit.edu	37	3	195397934	195397934	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:195397934delA	ENST00000445430.1	+	0	919																											AATATCTTGTAAAAAAAAGTA	0.343													11	37	---	---	---	---					
TFRC	7037	broad.mit.edu	37	3	195796404	195796404	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:195796404delT	ENST00000360110.4	-	7	892	c.723delA	c.(721-723)aafs	p.K241fs	TFRC_ENST00000420415.1_Frame_Shift_Del_p.K160fs|TFRC_ENST00000392396.3_Frame_Shift_Del_p.K241fs|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_5'UTR	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	241	PA.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		CCTCAAAATCTTTTTTAGTAC	0.343			T	BCL6	NHL								13	27	---	---	---	---					
UBXN7	26043	broad.mit.edu	37	3	196088753	196088753	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:196088753delT	ENST00000296328.4	-	10	1344	c.1270delA	c.(1270-1272)ggfs	p.R424fs	UBXN7_ENST00000535858.1_Frame_Shift_Del_p.R276fs|UBXN7_ENST00000428095.1_Frame_Shift_Del_p.R262fs	NM_015562.1	NP_056377.1	O94888	UBXN7_HUMAN	UBX domain protein 7	424	UBX.						protein binding			NS(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						ATCTGTTCCCTTTTTCCATCT	0.408													15	44	---	---	---	---					
SMCO1	255798	broad.mit.edu	37	3	196234827	196234827	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:196234827delC	ENST00000397537.2	-	3	732	c.576delG	c.(574-576)ggfs	p.G192fs		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		TAACTGCTTTCCCCTTCTCAA	0.458													21	41	---	---	---	---					
PIGZ	80235	broad.mit.edu	37	3	196674360	196674360	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr3:196674360delG	ENST00000412723.1	-	3	1554	c.1408delC	c.(1408-1410)ggfs	p.R470fs		NM_025163.2	NP_079439.2	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Z	470					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			breast(1)|endometrium(1)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	14	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		AGGAGGTGCCGGGGGGGCATG	0.642													18	90	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2695394	2695394	+	Frame_Shift_Del	DEL	C	C	-	rs3208084		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:2695394delC	ENST00000324666.5	+	14	2363	c.2012delC	c.(2011-2013)gcfs	p.A671fs	FAM193A_ENST00000545951.1_Frame_Shift_Del_p.A671fs|FAM193A_ENST00000505311.1_Frame_Shift_Del_p.A671fs|FAM193A_ENST00000382839.3_Frame_Shift_Del_p.A671fs|FAM193A_ENST00000502458.1_Frame_Shift_Del_p.A693fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	671								p.A671V(1)		NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						ACGGGCTTGGCCCCCCTCCCA	0.627													73	243	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19815895	19815896	+	RNA	DEL	AA	AA	-	rs145239076		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:19815895_19815896delAA	ENST00000511431.1	+	0	288																											TCTGGGCTGTaaaaaaaaaaaa	0.411													3	3	---	---	---	---					
CENPC	1060	broad.mit.edu	37	4	68355753	68355753	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:68355753delA	ENST00000273853.6	-	17	2852	c.2602delT	c.(2602-2604)ctfs	p.S868fs		NM_001812.2	NP_001803.2			centromere protein C																		TTCCCAGTAGAAAAAAAGGGT	0.343													8	18	---	---	---	---					
THAP6	152815	broad.mit.edu	37	4	76442067	76442067	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:76442067delA	ENST00000311638.3	+	3	234	c.166delA	c.(166-168)aafs	p.K57fs	THAP6_ENST00000502620.1_Frame_Shift_Del_p.K16fs|THAP6_ENST00000508105.1_Frame_Shift_Del_p.K16fs|THAP6_ENST00000507557.1_Frame_Shift_Del_p.K16fs|THAP6_ENST00000504190.1_Frame_Shift_Del_p.K16fs|THAP6_ENST00000507556.1_Frame_Shift_Del_p.K57fs|THAP6_ENST00000507885.1_Frame_Shift_Del_p.K16fs|THAP6_ENST00000380837.3_Frame_Shift_Del_p.K57fs|THAP6_ENST00000514480.1_Frame_Shift_Del_p.K57fs	NM_144721.4	NP_653322.1	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	57						microtubule cytoskeleton	DNA binding|metal ion binding			lung(5)	5			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TTGGGAGCCTAAAAAAGGAGA	0.378													9	121	---	---	---	---					
SCD5	79966	broad.mit.edu	37	4	83719663	83719664	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:83719663_83719664insC	ENST00000319540.4	-	1	346_347	c.27_28insG	c.(25-30)ggagatfs	p.D10fs	SCD5_ENST00000273908.4_Frame_Shift_Ins_p.D10fs|SCD5_ENST00000282709.4_Frame_Shift_Ins_p.D10fs	NM_001037582.2	NP_001032671.2	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5	10					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	13		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				AAAGGGATCTTCCCCGCGTCGG	0.752													7	19	---	---	---	---					
LARP7	51574	broad.mit.edu	37	4	113570754	113570754	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:113570754delA	ENST00000509061.1	+	11	1530	c.1227delA	c.(1225-1227)ttfs	p.L409fs	MIR302B_ENST00000510655.1_RNA|LARP7_ENST00000324052.6_Frame_Shift_Del_p.L402fs|LARP7_ENST00000344442.5_Frame_Shift_Del_p.L402fs	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	402					RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding	p.T405fs*5(2)		endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TGGCTTCTTTAAAAAAAACAA	0.333													10	14	---	---	---	---					
TNIP3	79931	broad.mit.edu	37	4	122068279	122068280	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:122068279_122068280delTC	ENST00000454328.1	-	9	886_887	c.659_660delGA	c.(658-660)afs	p.R220fs	TNIP3_ENST00000057513.3_Frame_Shift_Del_p.R220fs|TNIP3_ENST00000509841.1_Frame_Shift_Del_p.R297fs|TNIP3_ENST00000507879.1_Frame_Shift_Del_p.R290fs|TNIP3_ENST00000511909.1_5'UTR			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	220										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						CTTGATTAAGTCTCTCTCGATC	0.376													18	108	---	---	---	---					
SCLT1	132320	broad.mit.edu	37	4	129869675	129869675	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:129869675delT	ENST00000281142.5	-	15	1772	c.1269delA	c.(1267-1269)aafs	p.K423fs	SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Intron|SCLT1_ENST00000502495.1_5'UTR	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	423						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						CTTCCACTGCTTTTTTTTCCT	0.328													12	54	---	---	---	---					
NAA15	80155	broad.mit.edu	37	4	140291445	140291445	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:140291445delA	ENST00000296543.5	+	15	2157	c.1834delA	c.(1834-1836)aafs	p.K613fs	NAA15_ENST00000398947.1_Frame_Shift_Del_p.K613fs	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	613					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						agaagaagagaaaaaaaatgc	0.358													7	7	---	---	---	---					
OTUD4	54726	broad.mit.edu	37	4	146059009	146059010	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:146059009_146059010delTC	ENST00000454497.2	-	21	2859_2860	c.2722_2723delGA	c.(2722-2724)afs	p.E908fs	OTUD4_ENST00000447906.2_Frame_Shift_Del_p.E973fs|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	972							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					AGGCACAGTTTCTCTCTCTCTG	0.455													60	208	---	---	---	---					
TMA16	55319	broad.mit.edu	37	4	164428284	164428285	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:164428284_164428285insA	ENST00000358572.5	+	2	444_445	c.103_104insA	c.(103-105)aaafs	p.K35fs	TMA16_ENST00000511562.1_3'UTR|TMA16_ENST00000513134.1_Frame_Shift_Ins_p.K35fs|TMA16_ENST00000508268.1_Frame_Shift_Ins_p.K35fs|TMA16_ENST00000513272.1_Frame_Shift_Ins_p.K35fs	NM_018352.2	NP_060822.2	Q96EY4	CD043_HUMAN	translation machinery associated 16 homolog (S. cerevisiae)	35								p.K37fs*4(1)									CCACAAACAAGAAAAAAAGGAA	0.356													6	8	---	---	---	---					
TMA16	55319	broad.mit.edu	37	4	164435265	164435265	+	Frame_Shift_Del	DEL	A	A	-	rs2304802	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:164435265delA	ENST00000358572.5	+	4	535	c.194delA	c.(193-195)cafs	p.Q65fs	TMA16_ENST00000511562.1_3'UTR|TMA16_ENST00000513134.1_Frame_Shift_Del_p.Q65fs|TMA16_ENST00000508268.1_Frame_Shift_Del_p.Q65fs|TMA16_ENST00000513272.1_Frame_Shift_Del_p.Q65fs	NM_018352.2	NP_060822.2	Q96EY4	CD043_HUMAN	translation machinery associated 16 homolog (S. cerevisiae)	65			Q -> P (in dbSNP:rs2304802).					p.Q65P(2)									CTTGATCCCCAAAAAAAGAGA	0.358													17	61	---	---	---	---					
DDX60L	91351	broad.mit.edu	37	4	169325133	169325133	+	Splice_Site	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:169325133delA	ENST00000511577.1	-	25	3585	c.3338_splice	c.e25+1	p.L1113_splice	DDX60L_ENST00000260184.7_Splice_Site_p.L1113_splice|DDX60L_ENST00000505890.1_Splice_Site_p.L1113_splice			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1113							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AGTTACTTACAAAAAAAATAT	0.274													8	14	---	---	---	---					
LINC01098	285501	broad.mit.edu	37	4	178897081	178897082	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr4:178897081_178897082delTT	ENST00000507870.1	+	5	746_747	c.284_285delTT	c.(283-285)afs	p.I95fs																	lung(8)|prostate(1)	9						CTGAAGTATATTTTTTCTAAAT	0.376													55	145	---	---	---	---					
C5orf34	375444	broad.mit.edu	37	5	43487070	43487070	+	Frame_Shift_Del	DEL	T	T	-	rs142072137		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:43487070delT	ENST00000306862.2	-	13	2239	c.1864delA	c.(1864-1866)ccfs	p.T622fs	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968.1	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	622										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					ATTTCAGAGGTTTTTTTCAAT	0.289													8	33	---	---	---	---					
IL6ST	3572	broad.mit.edu	37	5	55247869	55247869	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:55247869delT	ENST00000381298.2	-	13	1899	c.1587delA	c.(1585-1587)aafs	p.K529fs	IL6ST_ENST00000381286.3_Intron|IL6ST_ENST00000381294.3_Frame_Shift_Del_p.K468fs|IL6ST_ENST00000536319.1_3'UTR|IL6ST_ENST00000502326.3_Frame_Shift_Del_p.K529fs|IL6ST_ENST00000336909.5_Frame_Shift_Del_p.K529fs|IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000522633.2_3'UTR|IL6ST_ENST00000381287.4_3'UTR	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	529	Fibronectin type-III 5.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity	p.V530fs*1(1)		breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				TTTTCCCTACTTTTTTTGTCC	0.348			O		hepatocellular ca								11	38	---	---	---	---					
MARVELD2	153562	broad.mit.edu	37	5	68737375	68737375	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:68737375delA	ENST00000325631.5	+	7	1645	c.1571delA	c.(1570-1572)gafs	p.E524fs	MARVELD2_ENST00000413223.2_Frame_Shift_Del_p.E408fs	NM_001038603.2|NM_001244734.1	NP_001033692.2|NP_001231663.1	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2	524					sensory perception of sound	integral to membrane|tight junction				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(4)|skin(1)|urinary_tract(1)	15		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		ACATTTCTGGAAAAAAAAGAA	0.323													7	32	---	---	---	---					
HAPLN1	1404	broad.mit.edu	37	5	82937358	82937358	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:82937358delT	ENST00000274341.4	-	5	1872	c.1022delA	c.(1021-1023)agfs	p.K341fs		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	341	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CAGCTTATGCTTTTTATCTGG	0.493													52	204	---	---	---	---					
ERAP1	51752	broad.mit.edu	37	5	96117518	96117518	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:96117518delC	ENST00000296754.3	-	16	2583	c.2326delG	c.(2326-2328)ccfs	p.A776fs	ERAP1_ENST00000443439.2_Frame_Shift_Del_p.A776fs|ERAP1_ENST00000514604.1_5'UTR	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	776					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		GTGCTCTGGGCCCCCACAGCA	0.458													14	66	---	---	---	---					
LVRN	206338	broad.mit.edu	37	5	115335468	115335468	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:115335468delT	ENST00000357872.4	+	7	1508	c.1384delT	c.(1384-1386)ttfs	p.F463fs	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		463					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										GAATGAGATCTTTTTTTCTAA	0.363													7	33	---	---	---	---					
TXNDC15	79770	broad.mit.edu	37	5	134210145	134210145	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:134210145delC	ENST00000358387.4	+	1	653	c.28delC	c.(28-30)ccfs	p.P10fs		NM_024715.3	NP_078991.3	Q96J42	TXD15_HUMAN	thioredoxin domain containing 15	10					cell redox homeostasis	integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCGACGACCGCCCCGCGTCAT	0.716													31	72	---	---	---	---					
PCDHB14	56122	broad.mit.edu	37	5	140604247	140604247	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140604247delT	ENST00000239449.4	+	1	1170	c.1170delT	c.(1168-1170)ccfs	p.P390fs	PCDHB14_ENST00000515856.2_Frame_Shift_Del_p.P237fs	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		390	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAACCTCCCTTTTTTCCTGA	0.443													8	223	---	---	---	---					
PCDHGB2	56103	broad.mit.edu	37	5	140741839	140741840	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140741839_140741840insA	ENST00000522605.1	+	1	2137_2138	c.2137_2138insA	c.(2137-2139)gcgfs	p.A713fs	PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1												p.L713L(1)		endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCAATCTCCCTGCGCCTGCGA	0.569													33	152	---	---	---	---					
PCDHGC3	5098	broad.mit.edu	37	5	140857741	140857742	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:140857741_140857742insA	ENST00000308177.3	+	1	2162_2163	c.2058_2059insA	c.(2056-2061)caaaaafs	p.QK686fs	PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGGGAGCAGAAAAAAAATCT	0.500											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	400	---	---	---	---					
PANK3	79646	broad.mit.edu	37	5	167986153	167986156	+	Frame_Shift_Del	DEL	TGTT	TGTT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:167986153_167986156delTGTT	ENST00000239231.6	-	6	1259_1262	c.943_946delAACA	c.(943-948)gafs	p.NR315fs	PANK3_ENST00000520504.1_5'UTR	NM_024594.3	NP_078870.1	Q9H999	PANK3_HUMAN	pantothenate kinase 3	315					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			NS(1)|cervix(2)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		AAGACAACTCTGTTTATTTTCTAA	0.250													8	29	---	---	---	---					
DOCK2	1794	broad.mit.edu	37	5	169116296	169116296	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:169116296delA	ENST00000256935.8	+	9	882	c.802delA	c.(802-804)agfs	p.K268fs		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	268					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGCTTCCCTAAGGAGATTGA	0.527													11	48	---	---	---	---					
MXD3	83463	broad.mit.edu	37	5	176738407	176738408	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:176738407_176738408insG	ENST00000427908.2	-	2	215_216	c.148_149insC	c.(148-150)ggcfs	p.G50fs	MXD3_ENST00000439742.2_Frame_Shift_Ins_p.G50fs|MXD3_ENST00000513063.1_Frame_Shift_Ins_p.G50fs|MXD3_ENST00000423571.2_Frame_Shift_Ins_p.G50fs	NM_001142935.1	NP_001136407.1	Q9BW11	MAD3_HUMAN	MAX dimerization protein 3	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding					all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCAGGAGCCTGGGGGGGTCGC	0.748													3	5	---	---	---	---					
PDLIM7	9260	broad.mit.edu	37	5	176916445	176916445	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:176916445delC	ENST00000355841.2	-	9	884	c.818delG	c.(817-819)gcfs	p.G273fs	PDLIM7_ENST00000393551.1_Frame_Shift_Del_p.G252fs|PDLIM7_ENST00000356618.4_Frame_Shift_Del_p.G252fs|PDLIM7_ENST00000359895.2_Frame_Shift_Del_p.G239fs	NM_005451.3	NP_005442.2	Q9NR12	PDLI7_HUMAN	PDZ and LIM domain 7 (enigma)	273					cell differentiation|multicellular organismal development|ossification|receptor-mediated endocytosis	cytoplasm|focal adhesion	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	10	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTGTTGCTGCCCCCTCCTGG	0.677													8	17	---	---	---	---					
FLT4	2324	broad.mit.edu	37	5	180053023	180053023	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr5:180053023delG	ENST00000261937.6	-	10	1345	c.1267delC	c.(1267-1269)agfs	p.Q423fs	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Frame_Shift_Del_p.Q423fs|FLT4_ENST00000502649.1_Frame_Shift_Del_p.Q423fs	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	423	Ig-like C2-type 5.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity	p.Q423fs*4(2)|p.Q233fs*4(1)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCATGTATCTGGGGGGGCACT	0.672													45	118	---	---	---	---					
DEK	7913	broad.mit.edu	37	6	18264188	18264188	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:18264188delC	ENST00000397239.3	-	2	478	c.31delG	c.(31-33)agfs	p.E11fs	DEK_ENST00000244776.7_Frame_Shift_Del_p.E11fs	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene	11					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			GGGGTTCCCTCCCCCTCCGCA	0.677			T	NUP214	AML								13	40	---	---	---	---					
PPP1R10	5514	broad.mit.edu	37	6	30572457	30572459	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30572457_30572459delGAA	ENST00000376511.2	-	12	1560_1562	c.1008_1010delTTC	c.(1006-1011)tcc>tc	p.SS336del		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	336	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TGGTTCTGGGGAAGAAGGTTTGG	0.522													93	449	---	---	---	---					
ATAT1	79969	broad.mit.edu	37	6	30613721	30613721	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:30613721delG	ENST00000330083.5	+	11	1300	c.982delG	c.(982-984)ggfs	p.G329fs	ATAT1_ENST00000468713.1_3'UTR|ATAT1_ENST00000376478.2_Frame_Shift_Del_p.G318fs|ATAT1_ENST00000376485.4_Frame_Shift_Del_p.G341fs	NM_001031722.2	NP_001026892.1	Q5SQI0	ATAT_HUMAN	alpha tubulin acetyltransferase 1	341							tubulin N-acetyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	9						CAGCCGCCATGGGGGGGTGAA	0.537													11	14	---	---	---	---					
RNF8	9025	broad.mit.edu	37	6	37344706	37344708	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:37344706_37344708delAGA	ENST00000373479.4	+	6	1326_1328	c.1133_1135delAGA	c.(1132-1137)gag>g	p.EK380del	RNF8_ENST00000469731.1_In_Frame_Del_p.EK380del	NM_003958.3|NM_183078.2	NP_003949.1|NP_898901.1	O76064	RNF8_HUMAN	ring finger protein 8, E3 ubiquitin protein ligase	380					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	13						TTGCAGGAAGAGAAGGAGAAGAT	0.404													10	65	---	---	---	---					
DNAH8	1769	broad.mit.edu	37	6	38810477	38810478	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:38810477_38810478insT	ENST00000359357.3	+	33	4246_4247	c.3992_3993insT	c.(3991-3993)gttfs	p.V1331fs	DNAH8_ENST00000441566.1_Frame_Shift_Ins_p.V1331fs|DNAH8_ENST00000449981.2_Frame_Shift_Ins_p.V1548fs					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GATTGGCAAGCTTTTTTGGATC	0.356													18	66	---	---	---	---					
GLP1R	2740	broad.mit.edu	37	6	39047367	39047367	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:39047367delC	ENST00000373256.4	+	11	1114	c.1071delC	c.(1069-1071)atfs	p.I357fs		NM_002062.3	NP_002053.3	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor	357					activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			breast(5)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	31					Exenatide(DB01276)|Glucagon recombinant(DB00040)	TGACACTCATCCCCCTGCTGG	0.567													23	53	---	---	---	---					
TREM1	54210	broad.mit.edu	37	6	41248876	41248876	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:41248876delG	ENST00000591620.1	-	3	448	c.422delC	c.(421-423)ctfs	p.P141fs	TREM1_ENST00000244709.4_Frame_Shift_Del_p.P141fs|TREM1_ENST00000589614.1_Frame_Shift_Del_p.P141fs|TREM1_ENST00000334475.6_Intron	NM_001242589.1	NP_001229518.1	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	141					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			NS(1)|breast(2)|endometrium(2)|large_intestine(5)|lung(5)|skin(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	ATTGGAGCCAGGGGTCCCTGA	0.488													13	50	---	---	---	---					
MUT	4594	broad.mit.edu	37	6	49427151	49427151	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:49427151delA	ENST00000274813.3	-	2	156	c.29delT	c.(28-30)tafs	p.L11fs		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	11					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGTGAAAGTAAAAAAAGCTG	0.413													14	68	---	---	---	---					
TFAP2D	83741	broad.mit.edu	37	6	50712845	50712845	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:50712845delT	ENST00000008391.3	+	6	1137	c.909delT	c.(907-909)gafs	p.D303fs	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	303	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TGGCTCGGGATTTTGGCTACA	0.433													14	54	---	---	---	---					
GCM1	8521	broad.mit.edu	37	6	52996817	52996817	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:52996817delA	ENST00000259803.7	-	4	640	c.429delT	c.(427-429)ttfs	p.F143fs		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	143						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					GGAAAAATATAAAGCGTCCGT	0.507													14	47	---	---	---	---					
EYS	346007	broad.mit.edu	37	6	66094366	66094367	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:66094366_66094367insT	ENST00000503581.1	-	8	1748_1749	c.1211_1212insA	c.(1210-1212)atgfs	p.M404fs	EYS_ENST00000393380.2_Frame_Shift_Ins_p.M404fs|EYS_ENST00000370618.3_Frame_Shift_Ins_p.M404fs|EYS_ENST00000342421.5_Frame_Shift_Ins_p.M404fs|EYS_ENST00000370616.2_Frame_Shift_Ins_p.M404fs|EYS_ENST00000370621.3_Frame_Shift_Ins_p.M404fs	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	404	EGF-like 5.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CTTTCTCACAGTTTTTTTCAGT	0.282													14	37	---	---	---	---					
RPF2	84154	broad.mit.edu	37	6	111306297	111306297	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:111306297delG	ENST00000441448.2	+	2	204	c.112delG	c.(112-114)ggfs	p.G39fs		NM_032194.1	NP_115570.1	Q9H7B2	RPF2_HUMAN	ribosome production factor 2 homolog (S. cerevisiae)	39	Brix.					nucleolus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|ovary(2)	7						GCTGATTAAAGGGGGAAATGC	0.328													26	219	---	---	---	---					
TNFAIP3	7128	broad.mit.edu	37	6	138199945	138199945	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:138199945delG	ENST00000237289.4	+	7	1429	c.1363delG	c.(1363-1365)ggfs	p.G456fs		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	456	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.P450fs*21(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		GGAGTCCACTGGGGGGCCTCA	0.657			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								15	75	---	---	---	---					
THBS2	7058	broad.mit.edu	37	6	169632254	169632255	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr6:169632254_169632255delTG	ENST00000366787.3	-	14	2220_2221	c.1971_1972delCA	c.(1969-1974)caacfs	p.HN657fs	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	657	EGF-like 3.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTGTGGCAGTTGTGTGTCTTGT	0.629													20	136	---	---	---	---					
DNAH11	8701	broad.mit.edu	37	7	21778377	21778378	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21778377_21778378insA	ENST00000328843.6	+	48	7756_7757	c.7725_7726insA	c.(7723-7728)aaaaaafs	p.KK2575fs	DNAH11_ENST00000409508.3_Frame_Shift_Ins_p.KK2568fs			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2575	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTGGAGGAAATAAAAAATTGAT	0.391									Kartagener syndrome				3	5	---	---	---	---					
DNAH11	8701	broad.mit.edu	37	7	21939669	21939669	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:21939669delA	ENST00000328843.6	+	82	13286	c.13255delA	c.(13255-13257)aafs	p.K4420fs	DNAH11_ENST00000409508.3_Frame_Shift_Del_p.K4413fs			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4420					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGATGTTACCAAAAAAACAAA	0.468									Kartagener syndrome				16	36	---	---	---	---					
IGF2BP3	10643	broad.mit.edu	37	7	23353164	23353165	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:23353164_23353165delCT	ENST00000258729.3	-	13	1859_1860	c.1503_1504delAG	c.(1501-1506)agttfs	p.RV501fs		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	501	KH 4.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						TTTCCAATAACTCTGCCAGCAG	0.416													36	133	---	---	---	---					
ANLN	54443	broad.mit.edu	37	7	36464330	36464331	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:36464330_36464331insA	ENST00000265748.2	+	17	2909_2910	c.2688_2689insA	c.(2686-2691)aaaaaafs	p.KK896fs	ANLN_ENST00000396068.2_Frame_Shift_Ins_p.KK859fs	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	896	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						TTGATAAGAAGAAAAAAACATC	0.297													12	37	---	---	---	---					
TRGC1	6966	broad.mit.edu	37	7	38305256	38305256	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:38305256delA	ENST00000443402.2	-	0	23					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					GGCTTGGGGGAAACATCTGCA	0.383													63	263	---	---	---	---					
ABCA13	154664	broad.mit.edu	37	7	48313595	48313595	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:48313595delA	ENST00000435803.1	+	17	4356	c.4332delA	c.(4330-4332)atfs	p.I1444fs		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1444					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGTTAAATATAAAAAAACCTC	0.269													14	51	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72236591	72236591	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:72236591delA	ENST00000438125.1	-	0	577							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										AAAAACAAACAAAAAAAACCT	0.333													8	25	---	---	---	---					
ASB15	142685	broad.mit.edu	37	7	123269113	123269113	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:123269113delT	ENST00000451558.1	+	12	1586	c.1065delT	c.(1063-1065)tafs	p.Y355fs	ASB15_ENST00000540573.1_Frame_Shift_Del_p.Y355fs|ASB15_ENST00000275699.3_Frame_Shift_Del_p.Y355fs|ASB15_ENST00000451215.1_Frame_Shift_Del_p.Y355fs|ASB15_ENST00000434204.1_Frame_Shift_Del_p.Y355fs			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	355					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						CTGCGCTGTATTTTGGCGTTT	0.448													36	102	---	---	---	---					
TNPO3	23534	broad.mit.edu	37	7	128610312	128610313	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:128610312_128610313insA	ENST00000393245.1	-	20	2962_2963	c.2589_2590insT	c.(2587-2592)ctgacafs	p.T864fs	TNPO3_ENST00000471166.1_Frame_Shift_Ins_p.T864fs|TNPO3_ENST00000471234.1_Frame_Shift_Ins_p.T766fs|TNPO3_ENST00000265388.5_Frame_Shift_Ins_p.T830fs|TNPO3_ENST00000482320.1_Frame_Shift_Ins_p.T764fs	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	830					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						AGCTGCTGTCCAAGCTGGTTCA	0.485													109	281	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131189175	131189177	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:131189175_131189177delCTC	ENST00000541194.1	-	9	1833_1835	c.1576_1578delGAG	c.(1576-1578)del	p.E526del	PODXL_ENST00000537928.1_In_Frame_Del_p.E492del|PODXL_ENST00000378555.3_In_Frame_Del_p.E524del|PODXL_ENST00000322985.9_In_Frame_Del_p.E492del	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	524					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.E524Q(1)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					CCACCTTCTTCTCCTGCATCTCA	0.567													24	144	---	---	---	---					
TRBV7-8	28590	broad.mit.edu	37	7	142099832	142099833	+	RNA	DEL	CA	CA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:142099832_142099833delCA	ENST00000390359.3	-	0	88																											accactctctcacacacacaca	0.455													22	65	---	---	---	---					
REPIN1	29803	broad.mit.edu	37	7	150069439	150069439	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150069439delC	ENST00000397281.2	+	4	1598	c.1109delC	c.(1108-1110)gcfs	p.A370fs	RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000489432.2_Frame_Shift_Del_p.A427fs|REPIN1_ENST00000425389.2_Frame_Shift_Del_p.A370fs|REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000540729.1_Frame_Shift_Del_p.A370fs|REPIN1_ENST00000444957.1_Frame_Shift_Del_p.A370fs	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	370	Pro-rich.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCGATCGAAGCCCCCCCCTCC	0.751													3	4	---	---	---	---					
SLC4A2	6522	broad.mit.edu	37	7	150764061	150764061	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:150764061delC	ENST00000485713.1	+	7	1987	c.947delC	c.(946-948)gcfs	p.A316fs	SLC4A2_ENST00000392826.2_Frame_Shift_Del_p.A307fs|SLC4A2_ENST00000413384.2_Frame_Shift_Del_p.A316fs|SLC4A2_ENST00000461735.1_Frame_Shift_Del_p.A302fs|SLC4A2_ENST00000310317.5_Frame_Shift_Del_p.A234fs	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	316	Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGACCCCGGGCCCCCCACAAG	0.637													38	136	---	---	---	---					
NUB1	51667	broad.mit.edu	37	7	151064135	151064135	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:151064135delA	ENST00000568733.1	+	9	1049	c.983delA	c.(982-984)gafs	p.E328fs	NUB1_ENST00000566856.1_Frame_Shift_Del_p.E304fs|NUB1_ENST00000355851.4_Frame_Shift_Del_p.E304fs|NUB1_ENST00000413040.2_Frame_Shift_Del_p.E328fs			Q9Y5A7	NUB1_HUMAN	negative regulator of ubiquitin-like proteins 1	304					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding			endometrium(1)|large_intestine(7)|lung(3)	11			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		GATGATGCAGAAAAAAAATTA	0.423													16	57	---	---	---	---					
GALNT11	63917	broad.mit.edu	37	7	151791468	151791468	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr7:151791468delA	ENST00000434507.1	+	4	593	c.156delA	c.(154-156)ccfs	p.P52fs	GALNT11_ENST00000415421.1_Frame_Shift_Del_p.P52fs|GALNT11_ENST00000482812.1_3'UTR|GALNT11_ENST00000452146.2_Intron|GALNT11_ENST00000320311.2_Frame_Shift_Del_p.P52fs|GALNT11_ENST00000430044.2_Frame_Shift_Del_p.P52fs|GALNT11_ENST00000422997.2_Frame_Shift_Del_p.P52fs			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	52						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		GACCATCTCCAAAAAAATTCT	0.473													44	159	---	---	---	---					
FBXO25	26260	broad.mit.edu	37	8	381399	381399	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:381399delA	ENST00000352684.2	+	3	459	c.42delA	c.(40-42)cgfs	p.R14fs	FBXO25_ENST00000350302.3_Frame_Shift_Del_p.K66fs|FBXO25_ENST00000276326.5_Frame_Shift_Del_p.K66fs|FBXO25_ENST00000382824.1_Frame_Shift_Del_p.R14fs	NM_012173.3	NP_036305.2	Q8TCJ0	FBX25_HUMAN	F-box protein 25	0	Interaction with beta-actin.					nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		ATATGCATCGAAAAAAAGGAA	0.259													17	100	---	---	---	---					
ERICH1	157697	broad.mit.edu	37	8	623865	623865	+	Frame_Shift_Del	DEL	T	T	-	rs145266372		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:623865delT	ENST00000262109.7	-	4	564	c.487delA	c.(487-489)ggfs	p.R163fs	ERICH1_ENST00000522706.1_Frame_Shift_Del_p.R69fs|ERICH1_ENST00000518277.1_5'UTR	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	163										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		TTCAGTTTCCTTTTTTTATTT	0.433													36	62	---	---	---	---					
SPAG11A	653423	broad.mit.edu	37	8	7718228	7718228	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:7718228delT	ENST00000326558.5	+	3	298	c.275delT	c.(274-276)ctfs	p.L92fs	SPAG11A_ENST00000454911.2_3'UTR|SPAG11A_ENST00000351436.4_Intron|SPAG11A_ENST00000434307.2_3'UTR|SPAG11A_ENST00000326625.5_Frame_Shift_Del_p.L39fs	NM_001081552.2	NP_001075021.2			sperm associated antigen 11A									p.L92H(1)		central_nervous_system(1)|lung(2)	3				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		ATCTGCAGACTTTTTTTCTGC	0.413													30	93	---	---	---	---					
TNKS	8658	broad.mit.edu	37	8	9567543	9567544	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:9567543_9567544insA	ENST00000310430.6	+	10	1683_1684	c.1657_1658insA	c.(1657-1659)aaafs	p.K553fs	TNKS_ENST00000518281.1_Frame_Shift_Ins_p.K316fs|TNKS_ENST00000520408.1_Frame_Shift_Ins_p.K553fs	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	553					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		AAATGTTAATGAAAAAAATAAA	0.342													7	39	---	---	---	---					
TNFRSF10D	8793	broad.mit.edu	37	8	22995432	22995432	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:22995432delT	ENST00000312584.3	-	9	1206	c.1112delA	c.(1111-1113)agfs	p.K371fs		NM_003840.4	NP_003831.2	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	371					anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		ATAAAAGAGCTTTTCGGAGCC	0.483													26	81	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28210819	28210819	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:28210819delG	ENST00000344423.5	-	5	821	c.690delC	c.(688-690)ccfs	p.P230fs	ZNF395_ENST00000523202.1_Frame_Shift_Del_p.P230fs|ZNF395_ENST00000523095.1_Frame_Shift_Del_p.P230fs	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	230					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGGGGGGCGAGGGGGTGGAGA	0.622													20	41	---	---	---	---					
RB1CC1	9821	broad.mit.edu	37	8	53586705	53586705	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:53586705delC	ENST00000025008.5	-	7	1225	c.702delG	c.(700-702)atfs	p.M234fs	RB1CC1_ENST00000435644.2_Frame_Shift_Del_p.M234fs|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000539297.1_Frame_Shift_Del_p.M234fs	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	234			M -> T (in dbSNP:rs17337252).		autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TGGATCTTTTCATCTCAGCTT	0.428													20	321	---	---	---	---					
TGS1	96764	broad.mit.edu	37	8	56711599	56711599	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:56711599delA	ENST00000260129.5	+	8	2146	c.1669delA	c.(1669-1671)aafs	p.K558fs		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	558					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CATGTCTGTTAAAAAAGGTGA	0.403													32	123	---	---	---	---					
LYN	4067	broad.mit.edu	37	8	56863054	56863054	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:56863054delA	ENST00000520220.2	+	5	532	c.258delA	c.(256-258)acfs	p.T86fs	LYN_ENST00000519728.1_Frame_Shift_Del_p.T107fs	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	107	SH3.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			CCCTTTTAACAAAAAAAGAAG	0.378													167	306	---	---	---	---					
SGK3	23678	broad.mit.edu	37	8	67752238	67752239	+	Splice_Site	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:67752238_67752239insT	ENST00000396596.1	+	11	956_957	c.741_splice	c.e11-1	p.F248_splice	SGK3_ENST00000520976.1_Splice_Site_p.F248_splice|SGK3_ENST00000521435.1_3'UTR|SGK3_ENST00000522398.1_Splice_Site_p.F248_splice|C8orf44-SGK3_ENST00000519289.1_Splice_Site_p.F248_splice|SGK3_ENST00000345714.4_Splice_Site_p.F248_splice|SGK3_ENST00000521198.2_Splice_Site_p.F248_splice	NM_013257.4	NP_037389.4	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase family, member 3	248	Protein kinase.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	18	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AATTTGACAGCTTTTTTTCCAC	0.401													18	111	---	---	---	---					
SLCO5A1	81796	broad.mit.edu	37	8	70744246	70744246	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:70744246delG	ENST00000260126.3	-	2	1369	c.663delC	c.(661-663)ccfs	p.P221fs	SLCO5A1_ENST00000530307.1_Frame_Shift_Del_p.P221fs|SLCO5A1_ENST00000524945.1_Frame_Shift_Del_p.P221fs|SLCO5A1_ENST00000528658.1_5'UTR	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	221						integral to membrane|plasma membrane	transporter activity	p.Y222fs*6(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGATCTGGTAGGGGGGCGAGA	0.677													18	46	---	---	---	---					
ZBTB10	65986	broad.mit.edu	37	8	81431473	81431473	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:81431473delA	ENST00000430430.1	+	7	3105	c.2326delA	c.(2326-2328)aafs	p.K777fs	ZBTB10_ENST00000426744.2_Frame_Shift_Del_p.K753fs|ZBTB10_ENST00000379091.4_Frame_Shift_Del_p.K485fs|ZBTB10_ENST00000455036.3_Frame_Shift_Del_p.K777fs	NM_001277145.1	NP_001264074.1	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10	777					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(4)	20	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			TAAAAAGGATAAAAAATACAA	0.338													17	62	---	---	---	---					
SLC7A13	157724	broad.mit.edu	37	8	87229783	87229784	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:87229783_87229784insA	ENST00000297524.3	-	3	1197_1198	c.1094_1095insT	c.(1093-1095)tacfs	p.Y365fs	SLC7A13_ENST00000419776.2_Frame_Shift_Ins_p.Y356fs	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	365						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						ATGAACCCGTGAAAAAAATATA	0.337													31	68	---	---	---	---					
KIAA1429	25962	broad.mit.edu	37	8	95531563	95531563	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:95531563delA	ENST00000297591.5	-	9	2238	c.2163delT	c.(2161-2163)ttfs	p.F721fs	KIAA1429_ENST00000421249.2_Frame_Shift_Del_p.F721fs|KIAA1429_ENST00000437199.1_Frame_Shift_Del_p.F721fs	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	721					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ATTCCGACATAAAAAAAAGAA	0.403													25	77	---	---	---	---					
PKHD1L1	93035	broad.mit.edu	37	8	110476892	110476892	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:110476892delT	ENST00000378402.5	+	49	7935	c.7831delT	c.(7831-7833)ttfs	p.F2612fs		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2612					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCTTGGCGAATTTTTTAACAA	0.443										HNSCC(38;0.096)			60	184	---	---	---	---					
TRPS1	7227	broad.mit.edu	37	8	116631857	116631857	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:116631857delG	ENST00000395715.3	-	3	1045	c.468delC	c.(466-468)ccfs	p.P156fs	TRPS1_ENST00000520276.1_Frame_Shift_Del_p.P147fs|TRPS1_ENST00000519674.1_Frame_Shift_Del_p.P143fs|TRPS1_ENST00000519076.1_Frame_Shift_Del_p.P97fs|TRPS1_ENST00000220888.5_Frame_Shift_Del_p.P143fs	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	143					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGTCCCCTGAGGGGGTGCAGG	0.532									Langer-Giedion syndrome				35	103	---	---	---	---					
COL14A1	7373	broad.mit.edu	37	8	121259922	121259922	+	Frame_Shift_Del	DEL	C	C	-	rs61738288	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:121259922delC	ENST00000297848.3	+	21	2820	c.2550delC	c.(2548-2550)gafs	p.D850fs	COL14A1_ENST00000309791.4_Frame_Shift_Del_p.D850fs|COL14A1_ENST00000247781.3_Frame_Shift_Del_p.D755fs|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	850	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTACGTGGGACCCCCCATCTT	0.463													46	128	---	---	---	---					
FAM91A1	157769	broad.mit.edu	37	8	124796763	124796767	+	Frame_Shift_Del	DEL	ACTCT	ACTCT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:124796763_124796767delACTCT	ENST00000334705.7	+	9	1003_1007	c.757_761delACTCT	c.(757-762)afs	p.TL253fs	FAM91A1_ENST00000521166.1_Frame_Shift_Del_p.TL253fs	NM_144963.2	NP_659400.2	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	253										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			TTATTTTGAAACTCTACTCTATAAG	0.317													10	65	---	---	---	---					
PUF60	22827	broad.mit.edu	37	8	144899293	144899295	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:144899293_144899295delAGG	ENST00000526683.1	-	11	1720_1722	c.1165_1167delCCT	c.(1165-1167)del	p.P389del	PUF60_ENST00000453551.2_In_Frame_Del_p.P346del|PUF60_ENST00000527197.1_In_Frame_Del_p.P343del|PUF60_ENST00000349157.6_In_Frame_Del_p.P372del|PUF60_ENST00000313352.7_In_Frame_Del_p.P329del|PUF60_ENST00000524570.1_5'UTR|PUF60_ENST00000456095.2_In_Frame_Del_p.P360del	NM_001271098.1|NM_078480.1	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	389	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGACCGGGATAGGAGGACGGGCT	0.631													11	24	---	---	---	---					
PLEC	5339	broad.mit.edu	37	8	145006691	145006692	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145006691_145006692insA	ENST00000322810.4	-	16	2433_2434	c.2264_2265insT	c.(2263-2265)tcafs	p.S755fs	PLEC_ENST00000356346.3_Frame_Shift_Ins_p.S604fs|PLEC_ENST00000354589.3_Frame_Shift_Ins_p.S618fs|PLEC_ENST00000357649.2_Frame_Shift_Ins_p.S622fs|PLEC_ENST00000354958.2_Frame_Shift_Ins_p.S596fs|PLEC_ENST00000436759.2_Frame_Shift_Ins_p.S645fs|PLEC_ENST00000527096.1_Frame_Shift_Ins_p.S641fs|PLEC_ENST00000345136.3_Frame_Shift_Ins_p.S618fs|PLEC_ENST00000398774.2_Frame_Shift_Ins_p.S586fs	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	755	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CAAAGCTGTGCAAGCTCTCCAG	0.644													76	122	---	---	---	---					
PLEC	5339	broad.mit.edu	37	8	145024532	145024532	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145024532delG	ENST00000322810.4	-	1	512	c.343delC	c.(343-345)acfs	p.H115fs	PLEC_ENST00000356346.3_Intron|PLEC_ENST00000354958.2_Intron|PLEC_ENST00000436759.2_Intron|PLEC_ENST00000527096.1_Intron	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	115	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCTGCACGTGGGGGGTGCGG	0.731													16	15	---	---	---	---					
ARHGAP39	80728	broad.mit.edu	37	8	145806259	145806277	+	Frame_Shift_Del	DEL	CGCCGCGGGCCGCCCGGCC	CGCCGCGGGCCGCCCGGCC	-	rs117042905	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr8:145806259_145806277delCGCCGCGGGCCGCCCGGCC	ENST00000276826.5	-	2	666_684	c.465_483delGGCCGGGCGGCCCGCGGCG	c.(463-483)agfs	p.RAGRPAA155fs	ARHGAP39_ENST00000377307.2_Frame_Shift_Del_p.RAGRPAA155fs|ARHGAP39_ENST00000540274.1_Frame_Shift_Del_p.RAGRPAA155fs			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	155					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CTGTCCCAAACGCCGCGGGCCGCCCGGCCCTCGCTGGCA	0.726													7	46	---	---	---	---					
CNTLN	54875	broad.mit.edu	37	9	17462981	17462983	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:17462981_17462983delAAG	ENST00000380647.3	+	20	3458_3460	c.3374_3376delAAG	c.(3373-3378)aaa>a	p.KE1125del	CNTLN_ENST00000262360.5_In_Frame_Del_p.KE1125del|CNTLN_ENST00000425824.1_In_Frame_Del_p.KE1125del			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	1125						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		CTCCTAGCAAAAGAAGAACACAT	0.320													9	56	---	---	---	---					
DENND4C	55667	broad.mit.edu	37	9	19296163	19296164	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:19296163_19296164insT	ENST00000380432.2	+	2	284_285	c.251_252insT	c.(250-252)cttfs	p.L84fs	DENND4C_ENST00000602925.1_Frame_Shift_Ins_p.L320fs|DENND4C_ENST00000307015.9_5'UTR|DENND4C_ENST00000434457.2_Frame_Shift_Ins_p.L320fs	NM_017925.4	NP_060395.5	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	84	DENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TCACACTGGCCTTTTTTTGAAG	0.366													28	133	---	---	---	---					
FOCAD	54914	broad.mit.edu	37	9	20758147	20758147	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:20758147delT	ENST00000380249.1	+	8	815	c.451delT	c.(451-453)ttfs	p.F151fs	FOCAD_ENST00000338382.6_Frame_Shift_Del_p.F151fs	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	151						integral to membrane	binding										CTGGCCAGTGTTTTTGCAGCA	0.408													16	56	---	---	---	---					
PTENP1	11191	broad.mit.edu	37	9	33675365	33675365	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:33675365delA	ENST00000532280.1	-	0	2132					NR_023917.1																						TATTGCCATTAAAAAAAAAGG	0.323													4	8	---	---	---	---					
C9orf131	138724	broad.mit.edu	37	9	35043650	35043650	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:35043650delC	ENST00000312292.5	+	2	1071	c.1024delC	c.(1024-1026)ccfs	p.P343fs	C9orf131_ENST00000421362.2_Frame_Shift_Del_p.P295fs|C9orf131_ENST00000354479.5_Frame_Shift_Del_p.P270fs	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	343										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TCCGATGCCACCCCCCTGCCA	0.527													133	634	---	---	---	---					
ZCCHC7	84186	broad.mit.edu	37	9	37357250	37357250	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:37357250delA	ENST00000336755.5	+	9	1723	c.1617delA	c.(1615-1617)agfs	p.R539fs	ZCCHC7_ENST00000534928.1_Frame_Shift_Del_p.R249fs|ZCCHC7_ENST00000461038.1_3'UTR	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	539			R -> K (in dbSNP:rs1051465).				nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		TTAAGCAGAGAAAAAAAAAGT	0.408													20	49	---	---	---	---					
SPATA31D5P	347127	broad.mit.edu	37	9	84531279	84531279	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:84531279delA	ENST00000527857.1	+	0	1301					NR_026851.1																						GAGACAAGTCAAAAAAAGGAG	0.393													4	9	---	---	---	---					
KIF27	55582	broad.mit.edu	37	9	86523470	86523470	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:86523470delT	ENST00000297814.2	-	3	539	c.396delA	c.(394-396)aafs	p.K132fs	KIF27_ENST00000413982.1_Frame_Shift_Del_p.K132fs|KIF27_ENST00000334204.2_Frame_Shift_Del_p.K132fs	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	132	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TATAAGATACTTTTACATTAA	0.378													46	127	---	---	---	---					
FGD3	89846	broad.mit.edu	37	9	95738900	95738900	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:95738900delC	ENST00000375482.3	+	3	858	c.362delC	c.(361-363)acfs	p.T121fs	FGD3_ENST00000468206.1_3'UTR|FGD3_ENST00000416701.2_Frame_Shift_Del_p.T121fs|FGD3_ENST00000337352.6_Frame_Shift_Del_p.T121fs	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	121					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.Q123fs*10(2)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						CCGAAGGTCACCCCCCAGGAG	0.662													18	45	---	---	---	---					
ERCC6L2	375748	broad.mit.edu	37	9	98774880	98774880	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:98774880delT	ENST00000407474.3	+	4	1504	c.991delT	c.(991-993)ttfs	p.F332fs				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	67	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										AGAAGAGGTGTTTTTTAATGA	0.348													12	62	---	---	---	---					
FKTN	2218	broad.mit.edu	37	9	108382270	108382270	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:108382270delT	ENST00000223528.2	+	9	1224	c.1100delT	c.(1099-1101)gtfs	p.V367fs	FKTN_ENST00000357998.5_Frame_Shift_Del_p.V367fs|FKTN_ENST00000448551.2_Frame_Shift_Del_p.V367fs|FKTN_ENST00000602661.1_Frame_Shift_Del_p.V367fs|FKTN_ENST00000540160.1_Intron	NM_006731.2	NP_006722.2	O75072	FKTN_HUMAN	fukutin	367					muscle organ development|negative regulation of cell proliferation|negative regulation of JNK cascade|nervous system development|regulation of protein glycosylation	cis-Golgi network|endoplasmic reticulum|extracellular space|Golgi membrane|integral to membrane|nucleus	transferase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	25						AAACTTGATGTTTTTTTCTTC	0.348													12	36	---	---	---	---					
CNTRL	11064	broad.mit.edu	37	9	123921184	123921184	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:123921184delA	ENST00000373855.1	+	31	5076	c.4816delA	c.(4816-4818)aafs	p.K1607fs	CNTRL_ENST00000238341.5_Frame_Shift_Del_p.K1607fs|CNTRL_ENST00000373844.1_Frame_Shift_Del_p.K52fs|CNTRL_ENST00000373850.1_Frame_Shift_Del_p.K1055fs|CNTRL_ENST00000373845.2_3'UTR			Q7Z7A1	CNTRL_HUMAN	centriolin	1607					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GTTAGGGCATAAAAAGGAGGA	0.493													47	161	---	---	---	---					
TTF1	7270	broad.mit.edu	37	9	135277541	135277541	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:135277541delT	ENST00000334270.2	-	2	707	c.668delA	c.(667-669)agfs	p.K225fs		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	225	Poly-Lys.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GGACTTTTTCTTTTTTTTCTT	0.493													13	46	---	---	---	---					
TSC1	7248	broad.mit.edu	37	9	135786806	135786808	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:135786806_135786808delGAG	ENST00000403810.1	-	10	1294_1296	c.1061_1063delCTC	c.(1060-1065)ctg>c	p.PL354del	TSC1_ENST00000440111.2_Intron|TSC1_ENST00000298552.3_Intron|TSC1_ENST00000545250.1_Intron			Q92574	TSC1_HUMAN	tuberous sclerosis 1	359					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CCAGAAAGCAGAGGAGAGAGCAG	0.468			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				29	95	---	---	---	---					
COL5A1	1289	broad.mit.edu	37	9	137642390	137642390	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr9:137642390delC	ENST00000371817.3	+	12	1911	c.1497delC	c.(1495-1497)ggfs	p.G499fs		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	499	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.P501fs*57(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GTCTTCAGGGCCCCCCTGGAC	0.667													27	79	---	---	---	---					
TUBB8	347688	broad.mit.edu	37	10	93252	93252	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:93252delC	ENST00000447903.2	-	4	1179	c.864delG	c.(862-864)ggfs	p.G288fs	TUBB8_ENST00000309812.4_Frame_Shift_Del_p.G360fs			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	360					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		ACATTTTTAGCCCCCGGGGTG	0.478													10	205	---	---	---	---					
UPF2	26019	broad.mit.edu	37	10	12021070	12021070	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:12021070delC	ENST00000356352.2	-	8	2412	c.1939delG	c.(1939-1941)atfs	p.D647fs	UPF2_ENST00000357604.5_Frame_Shift_Del_p.D647fs|UPF2_ENST00000397053.2_Frame_Shift_Del_p.D647fs			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	647	MIF4G 2.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				AATCTGAAATCCCCCCTCAGC	0.353													14	62	---	---	---	---					
OPTN	10133	broad.mit.edu	37	10	13151192	13151192	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:13151192delC	ENST00000378748.3	+	4	432	c.70delC	c.(70-72)ccfs	p.P25fs	OPTN_ENST00000378764.2_Frame_Shift_Del_p.P25fs|OPTN_ENST00000263036.5_Frame_Shift_Del_p.P25fs|OPTN_ENST00000378757.2_Frame_Shift_Del_p.P25fs|OPTN_ENST00000378752.3_Frame_Shift_Del_p.P25fs|OPTN_ENST00000378747.3_Frame_Shift_Del_p.P25fs|OPTN_ENST00000482140.1_3'UTR	NM_001008211.1|NM_001008213.1	NP_001008212.1|NP_001008214.1	Q96CV9	OPTN_HUMAN	optineurin	25					cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22						AGGAAATGGACCCCCCCACCT	0.557													57	199	---	---	---	---					
PTPLA	9200	broad.mit.edu	37	10	17636370	17636370	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:17636370delA	ENST00000361271.3	-	6	655	c.618delT	c.(616-618)ttfs	p.F206fs		NM_014241.3	NP_055056.3	B0YJ81	HACD1_HUMAN	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A	206					fatty acid biosynthetic process|multicellular organismal development|signal transduction	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	13						ATAAGATGATAAAAAAATTAT	0.313													13	52	---	---	---	---					
PARD3	56288	broad.mit.edu	37	10	34666942	34666942	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:34666942delC	ENST00000374789.3	-	10	1817	c.1492delG	c.(1492-1494)cgfs	p.A499fs	PARD3_ENST00000374776.1_Frame_Shift_Del_p.A499fs|PARD3_ENST00000350537.4_Frame_Shift_Del_p.A499fs|PARD3_ENST00000346874.4_Frame_Shift_Del_p.A499fs|PARD3_ENST00000374773.1_Frame_Shift_Del_p.A499fs|PARD3_ENST00000545693.1_Frame_Shift_Del_p.A499fs|PARD3_ENST00000340077.5_Frame_Shift_Del_p.A499fs|PARD3_ENST00000545260.1_Frame_Shift_Del_p.A455fs|PARD3_ENST00000374788.3_Frame_Shift_Del_p.A499fs|PARD3_ENST00000374790.3_Frame_Shift_Del_p.A455fs|PARD3_ENST00000544292.1_Frame_Shift_Del_p.A229fs|PARD3_ENST00000374794.3_Frame_Shift_Del_p.A455fs	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	499	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TGAATGGCCGCCCCCCGGGGG	0.483													49	177	---	---	---	---					
FAM21EP	100421577	broad.mit.edu	37	10	51821328	51821328	+	RNA	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:51821328delG	ENST00000456967.1	-	0	1306					NR_038275.1																						CGGTCAGCTTGGGGGGTGCGA	0.517													10	229	---	---	---	---					
FAM21EP	100421577	broad.mit.edu	37	10	51822385	51822385	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:51822385delA	ENST00000456967.1	-	0	1278					NR_038275.1																						GAATTCAGGGAAAAGGCCCAC	0.428													28	81	---	---	---	---					
ZSWIM8	23053	broad.mit.edu	37	10	75553466	75553466	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:75553466delC	ENST00000604729.1	+	11	2731	c.2434delC	c.(2434-2436)ccfs	p.P813fs	ZSWIM8_ENST00000431225.1_3'UTR|ZSWIM8_ENST00000603114.1_Frame_Shift_Del_p.P780fs|ZSWIM8_ENST00000398706.2_Frame_Shift_Del_p.P813fs|ZSWIM8_ENST00000604524.1_Frame_Shift_Del_p.P813fs|ZSWIM8_ENST00000605216.1_Frame_Shift_Del_p.P813fs					zinc finger, SWIM-type containing 8																		GGTAGAGCCGCCCCCTGCCAA	0.632													22	92	---	---	---	---					
PLAU	5328	broad.mit.edu	37	10	75673438	75673438	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:75673438delG	ENST00000446342.1	+	6	1033	c.551delG	c.(550-552)cgfs	p.R184fs	C10orf55_ENST00000409178.1_Intron|PLAU_ENST00000494287.1_3'UTR|PLAU_ENST00000372764.3_Frame_Shift_Del_p.R201fs|PLAU_ENST00000372762.4_Frame_Shift_Del_p.R165fs|C10orf55_ENST00000412307.2_Intron	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	201	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	AGGAGGCACCGGGGGGGCTCT	0.587													48	191	---	---	---	---					
STAMBPL1	57559	broad.mit.edu	37	10	90682146	90682146	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:90682146delA	ENST00000371927.3	+	10	2165	c.1207delA	c.(1207-1209)aafs	p.K405fs	STAMBPL1_ENST00000371926.3_Frame_Shift_Del_p.K405fs|STAMBPL1_ENST00000371924.1_Frame_Shift_Del_p.K405fs|STAMBPL1_ENST00000371922.1_Frame_Shift_Del_p.K239fs			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	405							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTCTGCTTGTAAAAAAAAGGG	0.423													45	46	---	---	---	---					
HTR7	3363	broad.mit.edu	37	10	92502258	92502258	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:92502258delT	ENST00000371721.3	-	4	1663	c.1421delA	c.(1420-1422)agfs	p.K474fs	HTR7_ENST00000277874.6_Frame_Shift_Del_p.K441fs|HTR7_ENST00000336152.3_Frame_Shift_Del_p.K474fs|HTR7_ENST00000371719.2_3'UTR			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	474					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	AATCATGACCTTTTTTTCTAC	0.328													13	46	---	---	---	---					
TM9SF3	56889	broad.mit.edu	37	10	98292810	98292810	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:98292810delT	ENST00000371142.4	-	10	1539	c.1323delA	c.(1321-1323)aafs	p.K441fs		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	441						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		CTCTTTACCATTTTTTCTCCG	0.378													41	129	---	---	---	---					
PAX2	5076	broad.mit.edu	37	10	102587324	102587324	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:102587324delC	ENST00000428433.1	+	11	1752	c.1202delC	c.(1201-1203)gcfs	p.A401fs	PAX2_ENST00000556085.1_Frame_Shift_Del_p.A377fs|PAX2_ENST00000355243.3_Frame_Shift_Del_p.A378fs|PAX2_ENST00000370296.2_3'UTR|PAX2_ENST00000361791.3_3'UTR	NM_003987.3|NM_003990.3	NP_003978.2|NP_003981.2	Q02962	PAX2_HUMAN	paired box 2	401					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		TATAGTGCCGCCCCCCGGGGC	0.572													31	122	---	---	---	---					
NT5C2	22978	broad.mit.edu	37	10	104857078	104857081	+	Frame_Shift_Del	DEL	AAGA	AAGA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:104857078_104857081delAAGA	ENST00000343289.5	-	10	825_828	c.738_741delTCTT	c.(736-741)ttfs	p.FL246fs	NT5C2_ENST00000369857.4_5'UTR|NT5C2_ENST00000423468.2_Frame_Shift_Del_p.FL217fs|NT5C2_ENST00000404739.3_Frame_Shift_Del_p.FL246fs	NM_001134373.2|NM_012229.4	NP_001127845.1|NP_036361.1	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	246					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|urinary_tract(1)	16		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	TGTTGGTAGCAAGAAATACTTTCC	0.343													24	106	---	---	---	---					
SH3PXD2A	9644	broad.mit.edu	37	10	105363391	105363391	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:105363391delG	ENST00000369774.4	-	15	1860	c.1584delC	c.(1582-1584)ccfs	p.P528fs	SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000538130.1_Frame_Shift_Del_p.P363fs|SH3PXD2A_ENST00000355946.2_Frame_Shift_Del_p.P500fs|SH3PXD2A_ENST00000427662.2_Intron|SH3PXD2A_ENST00000540321.1_Frame_Shift_Del_p.P395fs			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	528					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding	p.S501fs*43(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TGGGCTTGCTGGGGGGTGCTG	0.667													27	62	---	---	---	---					
ADD3	120	broad.mit.edu	37	10	111893350	111893350	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:111893350delA	ENST00000277900.8	+	14	2364	c.1999delA	c.(1999-2001)aafs	p.K669fs	ADD3_ENST00000356080.4_Frame_Shift_Del_p.K701fs|ADD3_ENST00000360162.3_Frame_Shift_Del_p.K669fs	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	701						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GAAAAAGAACAAAAAAAAGGA	0.333													34	125	---	---	---	---					
TECTB	6975	broad.mit.edu	37	10	114045891	114045891	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:114045891delA	ENST00000369422.3	+	3	330	c.330delA	c.(328-330)gtfs	p.V110fs		NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	110	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		CAGTGATTGTAAAAAACCAGC	0.473													20	115	---	---	---	---					
CASP7	840	broad.mit.edu	37	10	115485283	115485285	+	In_Frame_Del	DEL	TCT	TCT	-	rs141266925	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:115485283_115485285delTCT	ENST00000369321.2	+	6	958_960	c.638_640delTCT	c.(637-642)ctc>c	p.LF213del	CASP7_ENST00000369331.4_Intron|CASP7_ENST00000452490.2_In_Frame_Del_p.LF155del|CASP7_ENST00000369318.3_In_Frame_Del_p.LF180del|CASP7_ENST00000345633.4_In_Frame_Del_p.LF180del|CASP7_ENST00000369315.1_In_Frame_Del_p.LF180del	NM_033338.5	NP_203124.1	P55210	CASP7_HUMAN	caspase 7, apoptosis-related cysteine peptidase	180					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		AAACCCAAACTCTTCTTCATTCA	0.394													19	51	---	---	---	---					
DCLRE1A	9937	broad.mit.edu	37	10	115609831	115609832	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:115609831_115609832insA	ENST00000361384.2	-	2	1949_1950	c.1032_1033insT	c.(1030-1035)ttaaaafs	p.L344fs	DCLRE1A_ENST00000369305.1_Frame_Shift_Ins_p.L344fs	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	344					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGTCGTTTTTTAAAAAAACCAC	0.406								Other identified genes with known or suspected DNA repair function					29	129	---	---	---	---					
BAG3	9531	broad.mit.edu	37	10	121431867	121431867	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:121431867delG	ENST00000369085.3	+	3	914	c.608delG	c.(607-609)cgfs	p.R203fs		NM_004281.3	NP_004272.2	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	203					anti-apoptosis|apoptosis|protein folding	cytosol				endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(5)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	20		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		CAGCTCCCGCGGGGGTACATC	0.652													35	121	---	---	---	---					
GPR26	2849	broad.mit.edu	37	10	125447486	125447486	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr10:125447486delG	ENST00000284674.1	+	3	877	c.824delG	c.(823-825)tgfs	p.W275fs		NM_153442.3	NP_703143.1	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	275					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	20		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				GGCTCCCACTGGGGGGTGCTG	0.582													26	112	---	---	---	---					
PKP3	11187	broad.mit.edu	37	11	404002	404002	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:404002delC	ENST00000331563.2	+	11	2213	c.2137delC	c.(2137-2139)ccfs	p.P714fs		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	714					cell adhesion	desmosome|nucleus	binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGAGAAGTCGCCCCCAGCCGA	0.642													25	63	---	---	---	---					
MUC5B	727897	broad.mit.edu	37	11	1268066	1268066	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1268066delC	ENST00000447027.1	+	31	10023	c.9965delC	c.(9964-9966)acfs	p.T3322fs	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Frame_Shift_Del_p.T3319fs			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3319	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TTCACAGCCACCCCCTCCTCC	0.647													45	107	---	---	---	---					
CTSD	1509	broad.mit.edu	37	11	1780830	1780830	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1780830delG	ENST00000236671.2	-	3	400	c.268delC	c.(268-270)agfs	p.Q90fs		NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	90					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity	p.Q90fs*50(1)		endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTGAAGCACTGGGGGGGCGTC	0.647													19	81	---	---	---	---					
TNNI2	7136	broad.mit.edu	37	11	1862091	1862093	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:1862091_1862093delGAG	ENST00000381906.1	+	6	298_300	c.229_231delGAG	c.(229-231)del	p.E78del	TNNI2_ENST00000381911.1_In_Frame_Del_p.E78del|TNNI2_ENST00000252898.7_In_Frame_Del_p.E78del|TNNI2_ENST00000381905.3_In_Frame_Del_p.E78del	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	78					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCGGCTGAAGAGGAGAAGTACG	0.680													17	47	---	---	---	---					
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5653492	5653492	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:5653492delG	ENST00000354852.5	+	8	1166	c.993delG	c.(991-993)cafs	p.Q331fs	TRIM34_ENST00000514226.1_5'UTR|TRIM34_ENST00000429814.2_5'UTR|HBG2_ENST00000380259.2_Intron	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		331						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CAGCCATCCAGGGGTCTTTAA	0.438											OREG0003725	type=REGULATORY REGION|Gene=TRIM34|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	124	---	---	---	---					
RIC3	79608	broad.mit.edu	37	11	8161539	8161539	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:8161539delA	ENST00000343202.4	-	2	391	c.326delT	c.(325-327)tafs	p.L109fs	RIC3_ENST00000425599.2_Frame_Shift_Del_p.L109fs|RIC3_ENST00000309737.6_Frame_Shift_Del_p.L109fs|RIC3_ENST00000539720.1_Frame_Shift_Del_p.L60fs|RIC3_ENST00000335425.7_Intron|RIC3_ENST00000419822.2_Frame_Shift_Del_p.L109fs	NM_001206671.2|NM_024557.4	NP_001193600.1|NP_078833.3	Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	109						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		CAGTATATATAAAAAAATCCC	0.353													13	74	---	---	---	---					
SPTY2D1	144108	broad.mit.edu	37	11	18636367	18636367	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:18636367delG	ENST00000336349.5	-	3	1689	c.1454delC	c.(1453-1455)cgfs	p.P485fs		NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	485	Ser-rich.									breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						AGACCGCCCCGGGGGGCCCAA	0.597													17	69	---	---	---	---					
API5	8539	broad.mit.edu	37	11	43364020	43364020	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:43364020delG	ENST00000455725.2	+	15	1747	c.1502delG	c.(1501-1503)tgfs	p.W501fs	API5_ENST00000420461.2_3'UTR|API5_ENST00000534695.1_Intron|API5_ENST00000378852.3_3'UTR|API5_ENST00000531273.1_Frame_Shift_Del_p.W512fs|RP11-484D2.2_ENST00000526220.1_RNA			Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	0					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						GGCCGAGGTTGGGGCACACGA	0.463													22	98	---	---	---	---					
CHRM4	1132	broad.mit.edu	37	11	46407278	46407278	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:46407278delG	ENST00000433765.2	-	1	829	c.830delC	c.(829-831)cgfs	p.P278fs		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	278					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	CAGCGCTGGCGGGGGGGCCTC	0.672													11	31	---	---	---	---					
AGBL2	79841	broad.mit.edu	37	11	47684631	47684631	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:47684631delG	ENST00000525123.1	-	18	2767	c.2482delC	c.(2482-2484)tgfs	p.L828fs	AGBL2_ENST00000357610.3_Frame_Shift_Del_p.L830fs|AGBL2_ENST00000298861.4_Frame_Shift_Del_p.L828fs	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	828					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						GATGGGTCCAGGGGGGTGTCT	0.358													48	165	---	---	---	---					
OR4D10	390197	broad.mit.edu	37	11	59245082	59245082	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:59245082delT	ENST00000530162.1	+	1	237	c.180delT	c.(178-180)tafs	p.Y60fs		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CGCCCATGTATTTTTTGCTCC	0.438													59	231	---	---	---	---					
MTA2	9219	broad.mit.edu	37	11	62362913	62362914	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:62362913_62362914delGA	ENST00000278823.2	-	14	1694_1695	c.1305_1306delTC	c.(1303-1308)tcctfs	p.SP435fs	MTA2_ENST00000527204.1_Frame_Shift_Del_p.SP262fs|MTA2_ENST00000524902.1_Frame_Shift_Del_p.SP262fs	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	435					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						GTTGTGTAAGGAGAGAGACTTT	0.505													37	108	---	---	---	---					
INTS5	80789	broad.mit.edu	37	11	62415151	62415151	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:62415151delC	ENST00000330574.2	-	2	2453	c.2401delG	c.(2401-2403)cafs	p.A801fs		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	801					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AAGATGGGTGCCCCCCAGCAT	0.607													57	180	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65268677	65268678	+	RNA	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:65268677_65268678insG	ENST00000534336.1	+	0	3445_3446					NR_002819.2																						GTAACTGAGGCGGGGGGGAGTT	0.396													7	53	---	---	---	---					
YIF1A	10897	broad.mit.edu	37	11	66055346	66055346	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66055346delA	ENST00000376901.4	-	3	469	c.285delT	c.(283-285)ttfs	p.F95fs	YIF1A_ENST00000471387.2_Intron|YIF1A_ENST00000359461.6_Frame_Shift_Del_p.F95fs	NM_020470.2	NP_065203.2	O95070	YIF1A_HUMAN	Yip1 interacting factor homolog A (S. cerevisiae)	95					protein transport|vesicle-mediated transport	centrosome|endoplasmic reticulum membrane|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)|stomach(1)	9						TGTCCACAGCAAAAAAATACT	0.592													8	303	---	---	---	---					
KDM2A	22992	broad.mit.edu	37	11	66983411	66983412	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:66983411_66983412insG	ENST00000529006.2	+	8	1124_1125	c.678_679insG	c.(676-681)caggggfs	p.QG226fs	KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_Frame_Shift_Ins_p.QG226fs	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	226	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						ACATCCATCAAGGGGGAAAGGT	0.421													10	318	---	---	---	---					
PITPNM1	9600	broad.mit.edu	37	11	67267648	67267649	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:67267648_67267649insG	ENST00000356404.3	-	6	1109_1110	c.884_885insC	c.(883-885)cggfs	p.R295fs	PITPNM1_ENST00000436757.2_Frame_Shift_Ins_p.R295fs|PITPNM1_ENST00000534749.1_Frame_Shift_Ins_p.R295fs	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	295					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						CATCTGGGCCTGGGGGGGCCTC	0.693													34	95	---	---	---	---					
RELT	84957	broad.mit.edu	37	11	73101867	73101868	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:73101867_73101868insC	ENST00000064780.2	+	4	449_450	c.188_189insC	c.(187-189)accfs	p.T63fs	RELT_ENST00000393580.2_Frame_Shift_Ins_p.T63fs	NM_152222.1	NP_689408.1	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor	63						cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	12						TGGGGCTCCAGCCCATGCCAGC	0.649													11	132	---	---	---	---					
POLD3	10714	broad.mit.edu	37	11	74336609	74336609	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:74336609delA	ENST00000263681.2	+	8	1019	c.890delA	c.(889-891)gafs	p.E297fs	POLD3_ENST00000527458.1_Frame_Shift_Del_p.E258fs|POLD3_ENST00000532497.1_Frame_Shift_Del_p.E191fs	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	297					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					CTGCAGAAGGAAAAAAAAAGG	0.458													30	24	---	---	---	---					
SLCO2B1	11309	broad.mit.edu	37	11	74915461	74915463	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:74915461_74915463delTTC	ENST00000289575.5	+	14	2361_2363	c.1966_1968delTTC	c.(1966-1968)del	p.F658del	SLCO2B1_ENST00000454962.2_In_Frame_Del_p.F431del|SLCO2B1_ENST00000532236.1_In_Frame_Del_p.F542del|SLCO2B1_ENST00000341411.4_In_Frame_Del_p.F431del|SLCO2B1_ENST00000525650.1_In_Frame_Del_p.F514del|SLCO2B1_ENST00000428359.2_In_Frame_Del_p.F636del	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	658					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CGGCCTCCAGTTCTTCTTCAAAA	0.527													27	139	---	---	---	---					
GAB2	9846	broad.mit.edu	37	11	77934490	77934490	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:77934490delG	ENST00000361507.4	-	6	1620	c.1535delC	c.(1534-1536)ctfs	p.P512fs	GAB2_ENST00000340149.2_Frame_Shift_Del_p.P474fs	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	512					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			GCGGTTGACAGGGGGTGGCTG	0.552													53	120	---	---	---	---					
C11orf54	28970	broad.mit.edu	37	11	93486913	93486914	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:93486913_93486914insA	ENST00000528288.1	+	4	455_456	c.220_221insA	c.(220-222)aaafs	p.K74fs	C11orf54_ENST00000331239.4_Frame_Shift_Ins_p.K74fs|C11orf54_ENST00000540113.1_Frame_Shift_Ins_p.K55fs|C11orf54_ENST00000528099.1_Frame_Shift_Ins_p.K74fs|C11orf54_ENST00000354421.3_Frame_Shift_Ins_p.K74fs	NM_014039.2	NP_054758.2	Q9H0W9	CK054_HUMAN	chromosome 11 open reading frame 54	74						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(5)	8		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TCTTGTAAACCAAAAAAAAGTA	0.356													10	48	---	---	---	---					
CUL5	8065	broad.mit.edu	37	11	107965658	107965658	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:107965658delA	ENST00000393094.2	+	15	2303	c.1687delA	c.(1687-1689)aafs	p.K564fs		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	564					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		AGAATTCTACAAAAAAAATCA	0.373													17	49	---	---	---	---					
CD3G	917	broad.mit.edu	37	11	118220583	118220583	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118220583delA	ENST00000532917.1	+	3	273	c.205delA	c.(205-207)aafs	p.K71fs	CD3G_ENST00000392883.2_Frame_Shift_Del_p.K11fs|CD3G_ENST00000532903.1_3'UTR	NM_000073.2	NP_000064.1	P09693	CD3G_HUMAN	CD3g molecule, gamma (CD3-TCR complex)	71	Ig-like.				establishment or maintenance of cell polarity|protein complex assembly|protein transport|regulation of apoptosis|T cell activation|T cell costimulation|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	protein heterodimerization activity|receptor signaling complex scaffold activity|T cell receptor binding|transmembrane receptor activity			breast(2)|kidney(1)|large_intestine(2)|skin(1)	6	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		AACTGAAGATAAAAAAAAATG	0.403													30	118	---	---	---	---					
KMT2A	4297	broad.mit.edu	37	11	118369199	118369199	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118369199delA	ENST00000534358.1	+	22	5940	c.5917delA	c.(5917-5919)aafs	p.K1974fs	KMT2A_ENST00000389506.5_Frame_Shift_Del_p.K1971fs|KMT2A_ENST00000354520.4_Frame_Shift_Del_p.K1933fs	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		TCTGGATGATAAAAAAGTATA	0.418													91	241	---	---	---	---					
BCL9L	283149	broad.mit.edu	37	11	118773010	118773010	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:118773010delC	ENST00000334801.3	-	6	2406	c.1442delG	c.(1441-1443)gcfs	p.G481fs	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	481	Necessary for interaction with CTNNB1 (By similarity).|Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CAGCGGGGGGCCCCCTAGGCT	0.647													66	190	---	---	---	---					
CBL	867	broad.mit.edu	37	11	119149355	119149356	+	In_Frame_Ins	INS	-	-	ATG			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:119149355_119149356insATG	ENST00000264033.4	+	9	1739_1740	c.1363_1364insATG	c.(1363-1365)tga>ATGtga	p.454_455insM		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	454	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.E366_K477del(1)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTCCCCAAATTATGATGATGAT	0.475			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				23	86	---	---	---	---					
NFRKB	4798	broad.mit.edu	37	11	129752378	129752378	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:129752378delG	ENST00000446488.3	-	9	1153	c.1050delC	c.(1048-1050)ccfs	p.P350fs	NFRKB_ENST00000524746.1_Frame_Shift_Del_p.P350fs|NFRKB_ENST00000524794.1_Frame_Shift_Del_p.P375fs|NFRKB_ENST00000304521.5_Frame_Shift_Del_p.P350fs	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	350					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CCAGCGGAGAGGGGGCCTGTG	0.512													35	190	---	---	---	---					
NCAPD3	23310	broad.mit.edu	37	11	134048586	134048586	+	Frame_Shift_Del	DEL	G	G	-	rs138442478		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr11:134048586delG	ENST00000534548.2	-	22	2789	c.2725delC	c.(2725-2727)agfs	p.Q909fs		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	909					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding	p.Q909fs*12(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CCTCTGACCTGGGGGGGTGGC	0.522													8	118	---	---	---	---					
LTBR	4055	broad.mit.edu	37	12	6497628	6497630	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:6497628_6497630delCTC	ENST00000228918.4	+	7	1058_1060	c.732_734delCTC	c.(730-735)ttc>tt	p.FS244del	LTBR_ENST00000541102.1_Intron|LTBR_ENST00000539925.1_In_Frame_Del_p.FS225del|LTBR_ENST00000543190.1_3'UTR	NM_002342.1	NP_002333.1	P36941	TNR3_HUMAN	lymphotoxin beta receptor (TNFR superfamily, member 3)	244					apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			breast(1)|cervix(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15						CCACCGTCTTCTCCTGCATCTGG	0.576													50	96	---	---	---	---					
RECQL	5965	broad.mit.edu	37	12	21623985	21623986	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:21623985_21623986insTT	ENST00000444129.2	-	14	2182_2183	c.1714_1715insAA	c.(1714-1716)aggfs	p.R572fs	RECQL_ENST00000421138.2_Frame_Shift_Ins_p.R572fs	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	572					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						TTTAGGTCCTATTTTCAAATAC	0.366								Other identified genes with known or suspected DNA repair function					10	61	---	---	---	---					
MRPS35	60488	broad.mit.edu	37	12	27908288	27908288	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:27908288delA	ENST00000081029.3	+	8	948	c.877delA	c.(877-879)aafs	p.K294fs	MRPS35_ENST00000538315.1_3'UTR	NM_021821.3	NP_068593.2	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35	294					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				breast(1)|endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	6	Lung SC(9;0.0873)					TGAAGAGTACAAAAAGTCTGT	0.323													44	163	---	---	---	---					
BICD1	636	broad.mit.edu	37	12	32487496	32487496	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:32487496delA	ENST00000548411.1	+	6	2328	c.2147delA	c.(2146-2148)gafs	p.E716fs	BICD1_ENST00000281474.5_Frame_Shift_Del_p.E716fs	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	716	Interacts with RAB6A.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			TATGAAAATGAAAAAGCAATG	0.388													28	84	---	---	---	---					
ALG10	84920	broad.mit.edu	37	12	34179308	34179308	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:34179308delT	ENST00000266483.2	+	3	1199	c.880delT	c.(880-882)ttfs	p.F295fs	RP11-847H18.2_ENST00000501954.2_RNA|ALG10_ENST00000538927.1_Intron	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	295					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				ACTATTCTACTTTTTTTCATT	0.348													7	222	---	---	---	---					
SLC2A13	114134	broad.mit.edu	37	12	40153972	40153972	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:40153972delT	ENST00000280871.4	-	10	1853	c.1803delA	c.(1801-1803)aafs	p.K601fs		NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	601						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				TTTCCTCTAATTTTTTGCCTT	0.403										HNSCC(50;0.14)			21	58	---	---	---	---					
CNTN1	1272	broad.mit.edu	37	12	41365259	41365259	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:41365259delA	ENST00000547849.1	+	16	2147	c.1828delA	c.(1828-1830)aafs	p.K610fs	CNTN1_ENST00000551295.2_Intron|CNTN1_ENST00000547702.1_Frame_Shift_Del_p.K610fs|CNTN1_ENST00000347616.1_Intron|CNTN1_ENST00000348761.2_Intron|CNTN1_ENST00000360099.3_Frame_Shift_Del_p.K610fs	NM_001256064.1	NP_001242993.1	Q12860	CNTN1_HUMAN	contactin 1	0	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AGGTGGAGAGAAAAACATGGT	0.468													20	32	---	---	---	---					
RP11-478B9.1	0	broad.mit.edu	37	12	45466507	45466508	+	RNA	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:45466507_45466508insA	ENST00000548424.1	+	0	448																											GTTTCAAGGTTAAAAAAAAACC	0.381													5	11	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49440430	49440431	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49440430_49440431insG	ENST00000301067.7	-	15	4378_4379	c.4379_4380insC	c.(4378-4380)cctfs	p.P1460fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CGGTGAGCAGTGGGGGGTCCAG	0.564													43	224	---	---	---	---					
TUBA1A	7846	broad.mit.edu	37	12	49580268	49580268	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:49580268delG	ENST00000546918.1	-	2	438	c.352delC	c.(352-354)tgfs	p.L120fs	TUBA1A_ENST00000295766.5_Intron|TUBA1A_ENST00000550767.1_Intron|TUBA1A_ENST00000301071.7_Intron			Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	0					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						gggaggagcaggggggaggag	0.627													29	125	---	---	---	---					
COX14	84987	broad.mit.edu	37	12	50513902	50513902	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:50513902delG	ENST00000550487.1	+	2	407	c.76delG	c.(76-78)ggfs	p.G27fs	COX14_ENST00000548985.1_Frame_Shift_Del_p.G27fs|COX14_ENST00000550654.1_Frame_Shift_Del_p.G27fs|RP4-605O3.4_ENST00000552815.1_RNA|COX14_ENST00000317943.2_Frame_Shift_Del_p.G27fs	NM_001257134.1|NM_032901.3	NP_001244063.1|NP_116290.1	Q96I36	CL062_HUMAN	cytochrome c oxidase assembly homolog 14 (S. cerevisiae)	27						integral to membrane		p.G26W(1)									CACTGTGTATGGGGGGTACCT	0.522													45	94	---	---	---	---					
NR4A1	3164	broad.mit.edu	37	12	52448248	52448249	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52448248_52448249insC	ENST00000545748.1	+	3	1293_1294	c.298_299insC	c.(298-300)cccfs	p.P100fs	NR4A1_ENST00000243050.1_Frame_Shift_Ins_p.P46fs|NR4A1_ENST00000550082.1_Frame_Shift_Ins_p.P59fs|NR4A1_ENST00000360284.3_Frame_Shift_Ins_p.P59fs|NR4A1_ENST00000394824.2_Frame_Shift_Ins_p.P46fs|NR4A1_ENST00000548232.1_Frame_Shift_Ins_p.P46fs|NR4A1_ENST00000394825.1_Frame_Shift_Ins_p.P46fs|NR4A1_ENST00000547206.1_3'UTR			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	46					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		AGCCCCCGCTGCCCCCACTGCC	0.653													29	128	---	---	---	---					
KRT82	3888	broad.mit.edu	37	12	52799891	52799891	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:52799891delC	ENST00000257974.2	-	1	248	c.171delG	c.(169-171)ctfs	p.L57fs		NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	57	Head.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		CCACGTTGCACAGGCTCCGTG	0.687													13	40	---	---	---	---					
TENC1	23371	broad.mit.edu	37	12	53452903	53452903	+	Frame_Shift_Del	DEL	C	C	-	rs142183380		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:53452903delC	ENST00000314250.6	+	18	1768	c.1478delC	c.(1477-1479)acfs	p.T493fs	TENC1_ENST00000546602.1_Frame_Shift_Del_p.T493fs|TENC1_ENST00000379902.3_Frame_Shift_Del_p.T369fs|TENC1_ENST00000314276.3_Frame_Shift_Del_p.T503fs|TENC1_ENST00000451358.1_Frame_Shift_Del_p.T493fs|TENC1_ENST00000552570.1_Frame_Shift_Del_p.T493fs|TENC1_ENST00000549700.1_Frame_Shift_Del_p.T493fs	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	493	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding	p.A496fs*31(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CCCCGGCAGACCCCCCCGGCA	0.677													24	115	---	---	---	---					
OR6C65	403282	broad.mit.edu	37	12	55795221	55795222	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:55795221_55795222insA	ENST00000379665.2	+	1	1008_1009	c.909_910insA	c.(907-912)acaaaafs	p.TK303fs		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						GGGAATTCACCAAAAAAATATT	0.351													22	44	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56563405	56563405	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:56563405delC	ENST00000394023.3	-	25	2728	c.2623delG	c.(2623-2625)aafs	p.E875fs	SMARCC2_ENST00000347471.4_Frame_Shift_Del_p.E875fs|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000267064.4_Frame_Shift_Del_p.E844fs|SMARCC2_ENST00000550164.1_Frame_Shift_Del_p.E875fs	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	844					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			gtcttcctttccccctcagac	0.617													16	53	---	---	---	---					
RP11-74M13.4	0	broad.mit.edu	37	12	57255300	57255300	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:57255300delA	ENST00000557452.1	+	0	720																											TGGAAGAAGGAAaaaaaaata	0.423													24	35	---	---	---	---					
MGAT4C	25834	broad.mit.edu	37	12	86374168	86374168	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:86374168delT	ENST00000604798.1	-	8	1540	c.336delA	c.(334-336)aafs	p.K112fs	MGAT4C_ENST00000393205.2_Frame_Shift_Del_p.K141fs|MGAT4C_ENST00000548651.1_Frame_Shift_Del_p.K112fs|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000549405.2_Frame_Shift_Del_p.K112fs|MGAT4C_ENST00000332156.1_Frame_Shift_Del_p.K112fs|MGAT4C_ENST00000552808.2_Frame_Shift_Del_p.K112fs			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	112					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						AATAGTTTCCTTTTTTTCGCT	0.328													10	57	---	---	---	---					
CHPT1	56994	broad.mit.edu	37	12	102108338	102108338	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:102108338delT	ENST00000549872.1	+	3	668	c.478delT	c.(478-480)ttfs	p.F162fs	CHPT1_ENST00000550385.1_3'UTR|CHPT1_ENST00000229266.3_Frame_Shift_Del_p.F162fs			Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	162			F -> S (in dbSNP:rs3205421).		platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						TCCTGACTGGTTTTTTTTCTG	0.343													39	60	---	---	---	---					
CCDC63	160762	broad.mit.edu	37	12	111311659	111311659	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:111311659delA	ENST00000308208.5	+	5	625	c.383delA	c.(382-384)gafs	p.E128fs	CCDC63_ENST00000552694.1_Frame_Shift_Del_p.E49fs|CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000545036.1_Frame_Shift_Del_p.E88fs	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	128										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						CTTCAGATGGAAAAAAAAATC	0.413													43	79	---	---	---	---					
KSR2	283455	broad.mit.edu	37	12	117977605	117977605	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:117977605delG	ENST00000425217.1	-	10	1573	c.1519delC	c.(1519-1521)tcfs	p.L507fs	KSR2_ENST00000339824.5_Frame_Shift_Del_p.L536fs|KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000302438.5_Frame_Shift_Del_p.L233fs	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	536					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAGGAGGGAGGGGGGGTGCT	0.632													70	46	---	---	---	---					
HPD	3242	broad.mit.edu	37	12	122277894	122277895	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:122277894_122277895insT	ENST00000543163.1	-	14	1342_1343	c.897_898insA	c.(895-900)aacggtfs	p.NG299fs	HPD_ENST00000289004.4_Frame_Shift_Ins_p.NG338fs	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	338					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TCCTGCACCGGTTTGGTGAAGA	0.629													25	164	---	---	---	---					
ATP6V0A2	23545	broad.mit.edu	37	12	124229156	124229156	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124229156delT	ENST00000330342.3	+	12	1587	c.1339delT	c.(1339-1341)ttfs	p.F448fs		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	448					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		CATGAGGATGTTTTTTAATGG	0.532													25	102	---	---	---	---					
DNAH10	196385	broad.mit.edu	37	12	124265628	124265628	+	Splice_Site	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124265628delT	ENST00000409039.3	+	6	465	c.438_splice	c.e6-1	p.V147_splice		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	147	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCATTTCAGGTTTTTTTGCCA	0.368													23	57	---	---	---	---					
DNAH10	196385	broad.mit.edu	37	12	124274577	124274577	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124274577delC	ENST00000409039.3	+	11	1566	c.1541delC	c.(1540-1542)acfs	p.T514fs		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	514	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGCCTAGTCACCCCCATGGAA	0.473													59	305	---	---	---	---					
DNAH10	196385	broad.mit.edu	37	12	124415103	124415103	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124415103delA	ENST00000409039.3	+	72	12438	c.12413delA	c.(12412-12414)gafs	p.E4138fs	CCDC92_ENST00000544798.1_Intron|DNAH10OS_ENST00000514254.2_Intron	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4138					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GTTGGTGATGAAAAGGAGAAA	0.428													7	44	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124832801	124832801	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:124832801delG	ENST00000356219.3	-	30	4080	c.3925delC	c.(3925-3927)atfs	p.H1309fs	NCOR2_ENST00000429285.2_Frame_Shift_Del_p.H1292fs|NCOR2_ENST00000405201.1_Frame_Shift_Del_p.H1302fs|NCOR2_ENST00000404621.1_Frame_Shift_Del_p.H1292fs|NCOR2_ENST00000404121.2_Frame_Shift_Del_p.H863fs|NCOR2_ENST00000397355.1_Frame_Shift_Del_p.H1293fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1310					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCCGTCTCATGGGGGGGTCCT	0.632											OREG0022238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	161	---	---	---	---					
POLE	5426	broad.mit.edu	37	12	133245023	133245024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr12:133245023_133245024insG	ENST00000320574.5	-	19	2134_2135	c.2091_2092insC	c.(2089-2094)cctgttfs	p.V698fs	POLE_ENST00000535270.1_Frame_Shift_Ins_p.V671fs	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	698					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCTGGGAACAAGGGGGGGAACT	0.599								DNA polymerases (catalytic subunits)					119	222	---	---	---	---					
BRCA2	675	broad.mit.edu	37	13	32907421	32907421	+	Frame_Shift_Del	DEL	A	A	-	rs80359307		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:32907421delA	ENST00000544455.1	+	10	2033	c.1806delA	c.(1804-1806)ggfs	p.G602fs	BRCA2_ENST00000380152.3_Frame_Shift_Del_p.G602fs	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	602					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTTATAAAGGAAAAAAAATAC	0.303			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			12	46	---	---	---	---					
RFC3	5983	broad.mit.edu	37	13	34399981	34399982	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:34399981_34399982insA	ENST00000380071.3	+	4	479_480	c.349_350insA	c.(349-351)atcfs	p.I117fs	RFC3_ENST00000434425.1_Frame_Shift_Ins_p.I117fs	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	117					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		AACAGTGGCACAATCACAACAA	0.356													19	63	---	---	---	---					
NBEA	26960	broad.mit.edu	37	13	35672513	35672513	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:35672513delT	ENST00000400445.3	+	11	2185	c.1651delT	c.(1651-1653)ttfs	p.F551fs	NBEA_ENST00000379939.2_Frame_Shift_Del_p.F551fs|NBEA_ENST00000310336.4_Frame_Shift_Del_p.F551fs|NBEA_ENST00000540320.1_Frame_Shift_Del_p.F551fs	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	551						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGGAAAAGGCTTTTTAGTCAT	0.378													4	5	---	---	---	---					
DZIP1	22873	broad.mit.edu	37	13	96293851	96293853	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr13:96293851_96293853delAGA	ENST00000347108.3	-	3	725_727	c.293_295delTCT	c.(292-297)tgc>t	p.FC98del	DZIP1_ENST00000361156.3_In_Frame_Del_p.FC98del|DZIP1_ENST00000376829.2_In_Frame_Del_p.FC98del|DZIP1_ENST00000466027.1_5'UTR|DZIP1_ENST00000361396.2_In_Frame_Del_p.FC98del			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	98					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCCAGCTTGCAGAAGGTGATGTT	0.616													47	162	---	---	---	---					
LOC642426	642426	broad.mit.edu	37	14	19408019	19408019	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:19408019delA	ENST00000548050.1	-	0	279					NR_046104.1																						CTGTGGAGCCAAAAAAAAAAT	0.393													3	2	---	---	---	---					
OR4Q3	441669	broad.mit.edu	37	14	20215772	20215772	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20215772delT	ENST00000331723.1	+	1	186	c.186delT	c.(184-186)tafs	p.Y62fs		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTATGTATTATTTTTTAGGTC	0.408													66	373	---	---	---	---					
OR4K5	79317	broad.mit.edu	37	14	20389265	20389266	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20389265_20389266insT	ENST00000315915.4	+	1	525_526	c.500_501insT	c.(499-501)cttfs	p.L167fs		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGAACCTGCCTTTTTGTGGAC	0.441													7	768	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20858878	20858879	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20858878_20858879insA	ENST00000262715.5	-	15	2335_2336	c.2295_2296insT	c.(2293-2298)ttggaafs	p.LE765fs	TEP1_ENST00000556935.1_Frame_Shift_Ins_p.LE657fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	765					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGGTATTTCCCAAAAGTATTCA	0.455													11	76	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20876232	20876233	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:20876232_20876233delAC	ENST00000262715.5	-	2	406_407	c.366_367delGT	c.(364-369)gtctfs	p.VS122fs	TEP1_ENST00000556935.1_Frame_Shift_Del_p.VS122fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	122					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGGCTGGCAGACACAGTGCTCT	0.525													58	150	---	---	---	---					
ARHGEF40	55701	broad.mit.edu	37	14	21546604	21546604	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:21546604delG	ENST00000298694.4	+	10	2330	c.2203delG	c.(2203-2205)ggfs	p.G736fs	ARHGEF40_ENST00000298693.3_Frame_Shift_Del_p.G736fs			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	736					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GCAGAGGGATGGGGGGGCCAT	0.627													18	142	---	---	---	---					
C14orf93	60686	broad.mit.edu	37	14	23457145	23457145	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23457145delT	ENST00000299088.6	-	6	1593	c.1164delA	c.(1162-1164)aafs	p.K388fs	RP11-298I3.4_ENST00000555294.1_RNA|C14orf93_ENST00000406429.2_Frame_Shift_Del_p.K388fs|C14orf93_ENST00000397377.1_Frame_Shift_Del_p.K208fs|RP11-298I3.4_ENST00000556503.1_RNA|C14orf93_ENST00000397379.3_Frame_Shift_Del_p.K388fs|RP11-298I3.4_ENST00000557615.1_RNA|C14orf93_ENST00000397382.4_Frame_Shift_Del_p.K388fs|C14orf93_ENST00000341470.4_Frame_Shift_Del_p.K388fs	NM_001130708.1|NM_021944.2	NP_001124180.1|NP_068763.2	Q9H972	CN093_HUMAN	chromosome 14 open reading frame 93	388						extracellular region				kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	17	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		TCTTCTCCTCTTTTTCCTTCA	0.507													47	114	---	---	---	---					
CDH24	64403	broad.mit.edu	37	14	23523833	23523835	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:23523833_23523835delCTC	ENST00000397359.3	-	5	923_925	c.664_666delGAG	c.(664-666)del	p.E222del	CDH24_ENST00000554034.1_In_Frame_Del_p.E222del|CDH24_ENST00000487137.2_In_Frame_Del_p.E222del|CDH24_ENST00000267383.5_In_Frame_Del_p.E222del	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	222	Cadherin 2.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCACCAAGAACTCCTCCTGTGTC	0.626											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	98	---	---	---	---					
REC8	9985	broad.mit.edu	37	14	24648626	24648628	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:24648626_24648628delGAG	ENST00000311457.3	+	17	1872_1874	c.1273_1275delGAG	c.(1273-1275)del	p.E426del	REC8_ENST00000559919.1_In_Frame_Del_p.E426del			O95072	REC8_HUMAN	REC8 meiotic recombination protein	427	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(265;0.00839)		GGCAGCTGAAGAGGAGAAGTCCC	0.616													59	185	---	---	---	---					
NEMF	9147	broad.mit.edu	37	14	50272836	50272836	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:50272836delG	ENST00000298310.5	-	19	2209	c.1760delC	c.(1759-1761)cafs	p.P587fs	NEMF_ENST00000546046.1_Frame_Shift_Del_p.P566fs|NEMF_ENST00000545773.1_Frame_Shift_Del_p.P545fs|NEMF_ENST00000556925.1_5'UTR			O60524	NEMF_HUMAN	nuclear export mediator factor	587						cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						CAAGGTCCGTGGGGGGATGGG	0.468													10	40	---	---	---	---					
FBXO34	55030	broad.mit.edu	37	14	55817580	55817580	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:55817580delA	ENST00000313833.4	+	2	717	c.472delA	c.(472-474)aafs	p.K159fs	FBXO34_ENST00000440021.1_Frame_Shift_Del_p.K159fs	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	159										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						AGGGGATCTTAAAAAAGCCAA	0.438													27	50	---	---	---	---					
MTHFD1	4522	broad.mit.edu	37	14	64916254	64916254	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:64916254delG	ENST00000555709.1	+	24	2758	c.2371delG	c.(2371-2373)ggfs	p.G792fs	MTHFD1_ENST00000556284.1_3'UTR|ZBTB25_ENST00000555424.1_3'UTR|ZBTB25_ENST00000555220.1_3'UTR|MTHFD1_ENST00000216605.7_Frame_Shift_Del_p.G848fs|MTHFD1_ENST00000545908.1_Frame_Shift_Del_p.G848fs	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	792	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTGGGCAGAAGGGGGCAAGGG	0.567													33	110	---	---	---	---					
ADAM21	8747	broad.mit.edu	37	14	70925553	70925553	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:70925553delG	ENST00000603540.1	+	2	1595	c.1337delG	c.(1336-1338)ttfs	p.C446fs	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Frame_Shift_Del_p.C446fs	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	446	Disintegrin.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GGGGCTGCCTGTGCTTTTGGG	0.498													27	86	---	---	---	---					
PAPLN	89932	broad.mit.edu	37	14	73731295	73731295	+	Splice_Site	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:73731295delG	ENST00000427855.1	+	22	3088		c.e22-1		PAPLN_ENST00000555445.1_Splice_Site|PAPLN_ENST00000340738.5_Splice_Site|PAPLN_ENST00000381166.3_Splice_Site|PAPLN_ENST00000554301.1_Splice_Site			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein							proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CCTCATGACAGGGGGTGACAT	0.627													74	181	---	---	---	---					
NUMB	8650	broad.mit.edu	37	14	73759555	73759558	+	Frame_Shift_Del	DEL	TCTC	TCTC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:73759555_73759558delTCTC	ENST00000554546.1	-	7	657_660	c.301_304delGAGA	c.(301-306)aafs	p.EK101fs	NUMB_ENST00000454166.4_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000359560.3_Frame_Shift_Del_p.EK101fs|NUMB_ENST00000559312.1_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000556772.1_5'UTR|NUMB_ENST00000555238.1_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000555394.1_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000355058.3_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000356296.4_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000560335.1_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000557597.1_Frame_Shift_Del_p.EK101fs|NUMB_ENST00000554521.2_Frame_Shift_Del_p.EK101fs|NUMB_ENST00000544991.3_Frame_Shift_Del_p.EK112fs|NUMB_ENST00000535282.1_Frame_Shift_Del_p.EK101fs|NUMB_ENST00000555738.2_Frame_Shift_Del_p.EK101fs	NM_001005745.1	NP_001005745.1	P49757	NUMB_HUMAN	numb homolog (Drosophila)	112	PID.				axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		AAAGAAACTTTCTCTATCGTCTGG	0.441													29	76	---	---	---	---					
CLMN	79789	broad.mit.edu	37	14	95662949	95662949	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:95662949delT	ENST00000298912.4	-	10	2707	c.2594delA	c.(2593-2595)agfs	p.K865fs		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	865						integral to membrane	actin binding	p.K865fs*10(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		CCTTTTTTCCTTTTTTTTACT	0.408													24	44	---	---	---	---					
BCL11B	64919	broad.mit.edu	37	14	99642353	99642353	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:99642353delC	ENST00000345514.2	-	3	873	c.607delG	c.(607-609)tgfs	p.V203fs	BCL11B_ENST00000443726.2_Frame_Shift_Del_p.V80fs|BCL11B_ENST00000357195.3_Frame_Shift_Del_p.V274fs	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	274						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GACTGCGCCACGGCCTCCGGC	0.716			T	TLX3	T-ALL								7	15	---	---	---	---					
IGHA2	3494	broad.mit.edu	37	14	106054633	106054633	+	RNA	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:106054633delG	ENST00000390539.2	-	0	99																											AGTGGCTCCTGGGGGAAGAAG	0.637													29	94	---	---	---	---					
IGHV3-53	28420	broad.mit.edu	37	14	107048915	107048915	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr14:107048915delC	ENST00000390627.2	-	0	325																											gtctcagggaccccccaggct	0.587													7	133	---	---	---	---					
RTF1	23168	broad.mit.edu	37	15	41750018	41750019	+	Frame_Shift_Del	DEL	AG	AG	-	rs28645240		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:41750018_41750019delAG	ENST00000389629.4	+	4	618_619	c.606_607delAG	c.(604-609)aaagfs	p.KE202fs		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	202	Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		TGACAGAGAAAGAGAGAGAGCA	0.515													22	136	---	---	---	---					
EIF3J	8669	broad.mit.edu	37	15	44843099	44843099	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:44843099delA	ENST00000261868.5	+	3	311	c.173delA	c.(172-174)gafs	p.E58fs	EIF3J_ENST00000424492.3_Intron|EIF3J_ENST00000535391.1_Frame_Shift_Del_p.E58fs	NM_003758.2	NP_003749.2	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3, subunit J	58	Sufficient for interaction with EIF3B.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity	p.K60fs*36(1)		endometrium(1)|large_intestine(5)|liver(2)|skin(1)	9		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		GATGATGATGAAAAAAAAGAG	0.358													16	98	---	---	---	---					
PRTG	283659	broad.mit.edu	37	15	55912892	55912892	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:55912892delA	ENST00000389286.4	-	19	3214	c.3167delT	c.(3166-3168)tcfs	p.F1056fs		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1056					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TGAGTCTTGGAAAAAAAACCA	0.318													15	36	---	---	---	---					
RNF111	54778	broad.mit.edu	37	15	59376343	59376343	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:59376343delC	ENST00000348370.4	+	9	2746	c.2313delC	c.(2311-2313)cgfs	p.R771fs	RNF111_ENST00000434298.1_Frame_Shift_Del_p.R780fs|RNF111_ENST00000559209.1_Frame_Shift_Del_p.R780fs|RNF111_ENST00000557998.1_Frame_Shift_Del_p.R771fs|RNF111_ENST00000561186.1_Frame_Shift_Del_p.R780fs	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	771	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		CACATGAACGCCCCCCACCCC	0.443													16	57	---	---	---	---					
TM6SF1	53346	broad.mit.edu	37	15	83776522	83776525	+	Splice_Site	DEL	TGAG	TGAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:83776522_83776525delTGAG	ENST00000322019.9	+	1	364_366	c.92_splice	c.e1+1	p.Q30_splice	TM6SF1_ENST00000379386.4_Splice_Site_p.Q30_splice|TM6SF1_ENST00000565774.1_Splice_Site_p.Q30_splice|TM6SF1_ENST00000379390.6_Splice_Site_p.Q30_splice|TM6SF1_ENST00000564988.1_3'UTR			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	30						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CGGCCCAGCATGAGTGAGTGAgcc	0.721													7	33	---	---	---	---					
TICRR	90381	broad.mit.edu	37	15	90168411	90168411	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:90168411delC	ENST00000268138.7	+	20	4975	c.4870delC	c.(4870-4872)ccfs	p.P1625fs	KIF7_ENST00000558928.1_Intron|TICRR_ENST00000560985.1_Frame_Shift_Del_p.P1624fs					TOPBP1-interacting checkpoint and replication regulator																		CTATGTGTCACCCCCCTGCCC	0.627													13	60	---	---	---	---					
KIF7	374654	broad.mit.edu	37	15	90190140	90190140	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:90190140delC	ENST00000394412.3	-	7	1785	c.1709delG	c.(1708-1710)gtfs	p.G570fs		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	570					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GGCGTGGGCACCCCCCAGGGG	0.687											OREG0023460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	67	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320301	90320301	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr15:90320301delG	ENST00000341735.3	+	1	713	c.713delG	c.(712-714)agfs	p.R238fs	MESP2_ENST00000558723.1_Intron|MESP2_ENST00000560219.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	238					Notch signaling pathway	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			CGCCTGGGGAGGGGGGTCCAC	0.716													16	25	---	---	---	---					
MSLN	10232	broad.mit.edu	37	16	815293	815293	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:815293delC	ENST00000566549.1	+	8	1111	c.694delC	c.(694-696)ccfs	p.P233fs	MSLN_ENST00000545450.2_Frame_Shift_Del_p.P233fs|MSLN_ENST00000382862.3_Frame_Shift_Del_p.P233fs|MSLN_ENST00000563941.1_Frame_Shift_Del_p.P233fs			Q13421	MSLN_HUMAN	mesothelin	233					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				GGGCGGGGGACCCCCCTACGG	0.687													8	16	---	---	---	---					
RPUSD1	113000	broad.mit.edu	37	16	836088	836088	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:836088delG	ENST00000561734.1	-	5	1044	c.801delC	c.(799-801)ccfs	p.P267fs	RPUSD1_ENST00000007264.2_Frame_Shift_Del_p.P267fs|RPUSD1_ENST00000567114.1_Frame_Shift_Del_p.P138fs|RPUSD1_ENST00000565809.1_3'UTR			Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing 1	267	Pro-rich.				pseudouridine synthesis		pseudouridine synthase activity|RNA binding			endometrium(3)|lung(2)|skin(2)	7		Hepatocellular(780;0.00335)				TGCCTGGCCTGGGGCCCCTAT	0.731													21	40	---	---	---	---					
PKD1	5310	broad.mit.edu	37	16	2140883	2140886	+	Splice_Site	DEL	ACCT	ACCT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2140883_2140886delACCT	ENST00000262304.4	-	43	12210_12212	c.12003_splice	c.e43+1	p.I4001_splice	PKD1_ENST00000423118.1_Splice_Site_p.I4000_splice	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	4001					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCCAGCCCTCACCTTGACCAAAAG	0.711													10	32	---	---	---	---					
C16orf59	80178	broad.mit.edu	37	16	2510684	2510684	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:2510684delC	ENST00000569496.1	+	3	245	c.186delC	c.(184-186)gafs	p.D62fs	C16orf59_ENST00000483320.1_5'UTR|C16orf59_ENST00000361837.4_Frame_Shift_Del_p.D62fs|C16orf59_ENST00000563531.1_Frame_Shift_Del_p.D62fs			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	62										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				ATGGAGAGGACCCCCTTCCAG	0.642													13	49	---	---	---	---					
CLDN6	9074	broad.mit.edu	37	16	3065456	3065456	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3065456delC	ENST00000396925.1	-	3	995	c.567delG	c.(565-567)ggfs	p.G189fs	CLDN6_ENST00000572154.1_Intron|CLDN6_ENST00000328796.4_Frame_Shift_Del_p.G189fs			P56747	CLD6_HUMAN	claudin 6	189					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GGCCCTGGGACCCCCCCGAGG	0.642													23	68	---	---	---	---					
HCFC1R1	54985	broad.mit.edu	37	16	3073266	3073266	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3073266delG	ENST00000248089.3	-	3	553	c.249delC	c.(247-249)ccfs	p.P83fs	HCFC1R1_ENST00000574151.1_Frame_Shift_Del_p.P64fs|HCFC1R1_ENST00000354679.3_Frame_Shift_Del_p.P81fs|HCFC1R1_ENST00000574980.1_Frame_Shift_Del_p.P83fs|HCFC1R1_ENST00000396916.1_Frame_Shift_Del_p.P83fs|HCFC1R1_ENST00000572355.1_Frame_Shift_Del_p.P43fs	NM_017885.2	NP_060355.1	Q9NWW0	HPIP_HUMAN	host cell factor C1 regulator 1 (XPO1 dependent)	83						cytoplasm|nucleus		p.M65fs*1(1)		breast(1)|large_intestine(1)|upper_aerodigestive_tract(1)	3						AGAAGGTCATGGGGGGGCTGC	0.617													28	95	---	---	---	---					
CREBBP	1387	broad.mit.edu	37	16	3790495	3790496	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3790495_3790496insA	ENST00000262367.5	-	24	4846_4847	c.4037_4038insT	c.(4036-4038)tcgfs	p.S1346fs	CREBBP_ENST00000382070.3_Frame_Shift_Ins_p.S1308fs	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1346	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCTGGCGCCGCAAAAATTTGTT	0.569			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						23	73	---	---	---	---					
CREBBP	1387	broad.mit.edu	37	16	3820641	3820641	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3820641delG	ENST00000262367.5	-	14	3619	c.2810delC	c.(2809-2811)cgfs	p.P937fs	CREBBP_ENST00000382070.3_Frame_Shift_Del_p.P899fs	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	937					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGCCACAGACGGGGGCTGAAC	0.647			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						91	296	---	---	---	---					
CREBBP	1387	broad.mit.edu	37	16	3830807	3830809	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:3830807_3830809delAGG	ENST00000262367.5	-	8	2556_2558	c.1747_1749delCCT	c.(1747-1749)del	p.P583del	CREBBP_ENST00000382070.3_In_Frame_Del_p.P545del	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	583					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CGGTGCTAGAAGGAGGAGCTGCT	0.478			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						22	76	---	---	---	---					
NUDT16L1	84309	broad.mit.edu	37	16	4745140	4745142	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:4745140_4745142delAGA	ENST00000304301.6	+	3	629_631	c.596_598delAGA	c.(595-600)cag>c	p.QK199del	NUDT16L1_ENST00000586536.1_3'UTR|NUDT16L1_ENST00000586252.1_In_Frame_Del_p.QK159del|NUDT16L1_ENST00000405142.1_3'UTR	NM_032349.3	NP_115725.1	Q9BRJ7	SDOS_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	199	Interaction with PXN (By similarity).					cytoplasm	hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4						ACCGAGAAGCAGAAGAAGGCCCT	0.616													27	92	---	---	---	---					
ZC3H7A	29066	broad.mit.edu	37	16	11855799	11855799	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:11855799delT	ENST00000396516.2	-	17	2377	c.2180delA	c.(2179-2181)acfs	p.N727fs	ZC3H7A_ENST00000355758.4_Frame_Shift_Del_p.N727fs			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	727						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						ATATTTTCTGTTTTTGTCTGG	0.338													19	47	---	---	---	---					
NDE1	54820	broad.mit.edu	37	16	15785048	15785049	+	Frame_Shift_Ins	INS	-	-	C	rs113493697	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:15785048_15785049insC	ENST00000396355.1	+	7	1397_1398	c.571_572insC	c.(571-573)cccfs	p.P191fs	NDE1_ENST00000396354.1_Frame_Shift_Ins_p.P191fs|NDE1_ENST00000342673.5_Frame_Shift_Ins_p.P191fs|NDE1_ENST00000396353.2_Frame_Shift_Ins_p.P191fs	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	191	Interaction with CENPF (By similarity).			T -> I (in Ref. 3; AAH33900).	cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						GAAACCCAGGACCCCCATGCCC	0.609													20	108	---	---	---	---					
ARHGAP17	55114	broad.mit.edu	37	16	24942336	24942337	+	Frame_Shift_Ins	INS	-	-	G	rs144991183		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:24942336_24942337insG	ENST00000289968.6	-	19	2352_2353	c.2283_2284insC	c.(2281-2286)ccgtacfs	p.Y762fs	ARHGAP17_ENST00000303665.5_Frame_Shift_Ins_p.Y684fs|ARHGAP17_ENST00000441763.2_3'UTR	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	762	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GGCGGAGTACTGGGGGGCGTTG	0.609													29	261	---	---	---	---					
ZNF768	79724	broad.mit.edu	37	16	30536854	30536855	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:30536854_30536855insA	ENST00000380412.5	-	2	781_782	c.606_607insT	c.(604-609)ttgggafs	p.L202fs	ZNF768_ENST00000562803.1_Frame_Shift_Ins_p.L171fs	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	202					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						GGCTGCTCCCCAAACCCCTGAG	0.564													58	176	---	---	---	---					
RP11-19N8.4	0	broad.mit.edu	37	16	33070233	33070233	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:33070233delC	ENST00000561541.1	-	0	291																											CGGCTTTTTGCCCCCCCTGCC	0.637													4	3	---	---	---	---					
TOX3	27324	broad.mit.edu	37	16	52473205	52473206	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:52473205_52473206delGA	ENST00000219746.9	-	7	1946_1947	c.1662_1663delTC	c.(1660-1665)tcagfs	p.SQ554fs	TOX3_ENST00000407228.3_Frame_Shift_Del_p.SQ549fs	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	554	Gln-rich.				apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						TGGTGCTGCTGAGAGGCTGGCT	0.550													7	52	---	---	---	---					
RSPRY1	89970	broad.mit.edu	37	16	57255241	57255241	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:57255241delG	ENST00000537866.1	+	10	1948	c.1075delG	c.(1075-1077)ggfs	p.G359fs	RSPRY1_ENST00000394420.4_Frame_Shift_Del_p.G359fs			Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	359	B30.2/SPRY.					extracellular region	zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|urinary_tract(3)	27						TGTGGATGCCGGGGTATGGTA	0.488													46	144	---	---	---	---					
CMTM1	113540	broad.mit.edu	37	16	66603929	66603930	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:66603929_66603930insT	ENST00000379500.2	+	2	590_591	c.523_524insT	c.(523-525)tttfs	p.F175fs	CMTM1_ENST00000528324.1_Frame_Shift_Ins_p.F58fs|CKLF-CMTM1_ENST00000527729.1_Intron|CMTM1_ENST00000531885.1_Intron|CMTM1_ENST00000533666.1_Intron|CMTM1_ENST00000533953.1_Intron|CMTM1_ENST00000457188.2_Frame_Shift_Ins_p.F58fs|CMTM1_ENST00000535705.1_Intron|CMTM1_ENST00000328020.6_Frame_Shift_Ins_p.F175fs|CMTM1_ENST00000336328.6_Intron|CMTM1_ENST00000332695.7_Intron	NM_052999.3|NM_181268.2	NP_443725.3|NP_851785.2	Q8IZ96	CKLF1_HUMAN	CKLF-like MARVEL transmembrane domain containing 1	58					chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		CTGCATTGTCGTTTTTTTTATT	0.347													44	157	---	---	---	---					
CTCF	10664	broad.mit.edu	37	16	67645338	67645339	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:67645338_67645339insA	ENST00000264010.4	+	3	1047_1048	c.603_604insA	c.(601-606)gcaaaafs	p.AK201fs	CTCF_ENST00000401394.1_Intron	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	201					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGCCACCAGCCAAAAAAACAAA	0.475													22	76	---	---	---	---					
DDX19B	11269	broad.mit.edu	37	16	70365775	70365776	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:70365775_70365776delGT	ENST00000288071.6	+	10	1419_1420	c.1174_1175delGT	c.(1174-1176)gfs	p.V392fs	RP11-529K1.3_ENST00000567706.1_Intron|DDX19B_ENST00000563206.1_Frame_Shift_Del_p.V397fs|DDX19B_ENST00000355992.3_Frame_Shift_Del_p.V361fs|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000451014.3_Frame_Shift_Del_p.V366fs|DDX19B_ENST00000568625.1_Frame_Shift_Del_p.V283fs|DDX19B_ENST00000393657.2_Frame_Shift_Del_p.V283fs|DDX19B_ENST00000563392.1_Frame_Shift_Del_p.V283fs	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	392	Helicase C-terminal.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				GACCACCAACGTGTGTGCCCGC	0.599											OREG0023914	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	75	---	---	---	---					
RP11-77K12.5	0	broad.mit.edu	37	16	75538613	75538613	+	RNA	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:75538613delG	ENST00000571737.1	-	0	408																											ACAGCTCAGCGGCTGCTTCTG	0.537													28	152	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81155069	81155069	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:81155069delA	ENST00000534142.1	-	0	1000				PKD1L2_ENST00000533478.1_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						actccatctcaaaaaaaaaaa	0.527													3	6	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81187706	81187707	+	RNA	DEL	CT	CT	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:81187706_81187707delCT	ENST00000533478.1	-	0	2320_2321				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GGTGGTGGGGCTCTCTCTCTCC	0.604													11	27	---	---	---	---					
JPH3	57338	broad.mit.edu	37	16	87678537	87678537	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr16:87678537delC	ENST00000284262.2	+	2	1298	c.1056delC	c.(1054-1056)atfs	p.I352fs		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	352					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		AGAACCTCATCCCCCTGCGGG	0.662													21	66	---	---	---	---					
PITPNA	5306	broad.mit.edu	37	17	1456400	1456400	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:1456400delT	ENST00000313486.7	-	3	350	c.95delA	c.(94-96)atfs	p.N32fs	PITPNA_ENST00000539476.1_Frame_Shift_Del_p.N32fs	NM_006224.3	NP_006215.1	Q00169	PIPNA_HUMAN	phosphatidylinositol transfer protein, alpha	32					axon guidance|lipid metabolic process|visual perception	cytoplasm	phosphatidylcholine transmembrane transporter activity|phosphatidylinositol transporter activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7				UCEC - Uterine corpus endometrioid carcinoma (25;0.0845)		ACCCGTTTCATTTTTACTGGC	0.517													42	145	---	---	---	---					
LOC100130950	100130950	broad.mit.edu	37	17	5096766	5096766	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:5096766delA	ENST00000571689.1	+	0	60				RP11-333E1.1_ENST00000575601.1_RNA	NR_034082.1																						tcaaaaaaataaaaaaaaaaa	0.507													3	5	---	---	---	---					
EPN2	22905	broad.mit.edu	37	17	19232949	19232950	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:19232949_19232950insA	ENST00000314728.5	+	9	1884_1885	c.1400_1401insA	c.(1399-1401)taafs	p.*467fs	EPN2_ENST00000571254.1_Frame_Shift_Ins_p.*403fs|EPN2_ENST00000395626.1_Frame_Shift_Ins_p.*467fs|EPN2_ENST00000347697.2_Frame_Shift_Ins_p.*410fs|EPN2_ENST00000575595.1_Frame_Shift_Ins_p.*175fs|EPN2_ENST00000395620.2_Frame_Shift_Ins_p.*410fs|EPN2_ENST00000395618.3_Frame_Shift_Ins_p.*182fs	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	467	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding	p.T470fs*19(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CTTCGGACTTCAAAAAAAACAG	0.396													28	86	---	---	---	---					
KCNJ12	3768	broad.mit.edu	37	17	21319454	21319459	+	In_Frame_Del	DEL	CCATCA	CCATCA	-	rs140687028	byFrequency	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:21319454_21319459delCCATCA	ENST00000583088.1	+	3	1695_1700	c.800_805delCCATCA	c.(799-807)ccc>c	p.PIT267del	KCNJ12_ENST00000331718.5_In_Frame_Del_p.PIT267del	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.P267H(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CTGGTGTCGCCCATCACCATCTTGCA	0.607										Prostate(3;0.18)			9	124	---	---	---	---					
CRYBA1	1411	broad.mit.edu	37	17	27579135	27579137	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:27579135_27579137delGAG	ENST00000225387.3	+	4	270_272	c.269_271delGAG	c.(268-273)aga>a	p.RG90del		NM_005208.4	NP_005199.2	P05813	CRBA1_HUMAN	crystallin, beta A1	90	Beta/gamma crystallin 'Greek key' 2.				visual perception	soluble fraction	structural constituent of eye lens			breast(1)|large_intestine(2)|lung(1)|prostate(1)	5			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			ATCCTGGAGAGAGGAGAATACCC	0.493											OREG0024293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	112	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29553477	29553478	+	Frame_Shift_Ins	INS	-	-	C	rs145092683		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:29553477_29553478insC	ENST00000358273.4	+	18	2409_2410	c.2026_2027insC	c.(2026-2028)cccfs	p.P676fs	NF1_ENST00000356175.3_Frame_Shift_Ins_p.P676fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	676					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)|p.P678fs*10(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGCAGCGGAACCCCCCCGATT	0.460			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			14	67	---	---	---	---					
EVI2A	2123	broad.mit.edu	37	17	29645893	29645893	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:29645893delT	ENST00000247270.3	-	3	544	c.208delA	c.(208-210)ttfs	p.I70fs	NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron|NF1_ENST00000581113.2_Intron|EVI2A_ENST00000462804.2_Frame_Shift_Del_p.I47fs|EVI2A_ENST00000461237.1_Frame_Shift_Del_p.I47fs	NM_001003927.2	NP_001003927.1	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A	47						integral to membrane	transmembrane receptor activity	p.0?(8)|p.?(3)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		TTGTTTTGAATAACTGAATCC	0.373													58	150	---	---	---	---					
CDK12	51755	broad.mit.edu	37	17	37687472	37687472	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:37687472delG	ENST00000447079.4	+	14	4409	c.4376delG	c.(4375-4377)tgfs	p.W1459fs	CDK12_ENST00000430627.2_Frame_Shift_Del_p.W1450fs	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1459					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						GGCCTTCACTGGGGGGGCCCA	0.562			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			28	117	---	---	---	---					
CCR7	1236	broad.mit.edu	37	17	38715180	38715180	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:38715180delT	ENST00000246657.2	-	2	87	c.25delA	c.(25-27)gcfs	p.S9fs	CCR7_ENST00000579344.1_Frame_Shift_Del_p.S3fs	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	9					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				ACCAGCACGCTTTTCATTGGT	0.507													15	74	---	---	---	---					
KRT28	162605	broad.mit.edu	37	17	38953467	38953467	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:38953467delC	ENST00000306658.7	-	4	822	c.757delG	c.(757-759)tafs	p.V253fs		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	253	Linker 12.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				GCGAGGTCTACCCCCGGGGCC	0.597													12	143	---	---	---	---					
KRT14	3861	broad.mit.edu	37	17	39742887	39742887	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:39742887delC	ENST00000167586.6	-	1	286	c.200delG	c.(199-201)gcfs	p.G68fs		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	68	Head.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				GCCATAGCCGCCCCCCAGCCC	0.682													7	22	---	---	---	---					
HOXB3	3213	broad.mit.edu	37	17	46628440	46628440	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:46628440delC	ENST00000470495.1	-	2	1999	c.552delG	c.(550-552)ggfs	p.G184fs	HOXB3_ENST00000311626.4_Frame_Shift_Del_p.G184fs|HOXB3_ENST00000472863.1_Frame_Shift_Del_p.G111fs|HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000490677.1_Frame_Shift_Del_p.G50fs|HOXB3_ENST00000489475.1_Frame_Shift_Del_p.G111fs|HOXB3_ENST00000460160.1_Frame_Shift_Del_p.G52fs|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000485909.2_Frame_Shift_Del_p.G52fs|HOXB3_ENST00000498678.1_Frame_Shift_Del_p.G184fs|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000476342.1_Frame_Shift_Del_p.G184fs			P14651	HXB3_HUMAN	homeobox B3	184					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						ACGCCGCCGACCCCGGGGGGC	0.761													19	74	---	---	---	---					
TMEM92	162461	broad.mit.edu	37	17	48356598	48356598	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:48356598delC	ENST00000300433.3	+	6	519	c.409delC	c.(409-411)ccfs	p.P139fs	TMEM92_ENST00000507382.1_Frame_Shift_Del_p.P139fs	NM_001168215.1	NP_001161687.1	Q6UXU6	TMM92_HUMAN	transmembrane protein 92	139	Pro-rich.					integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(1)	7						CACAGAGCCACCCCCTCCCTA	0.597													91	384	---	---	---	---					
XYLT2	64132	broad.mit.edu	37	17	48433967	48433967	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:48433967delC	ENST00000017003.2	+	8	1627	c.1578delC	c.(1576-1578)tafs	p.Y526fs	XYLT2_ENST00000507602.1_Frame_Shift_Del_p.Y526fs	NM_022167.2	NP_071450.2	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	526					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity	p.G529fs*17(1)		endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(2)|urinary_tract(1)	12	Breast(11;7.18e-19)					ATGGCAGCTACCCCCCCGGCA	0.602													39	90	---	---	---	---					
LUC7L3	51747	broad.mit.edu	37	17	48819046	48819046	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:48819046delA	ENST00000505658.1	+	5	569	c.380delA	c.(379-381)gafs	p.E127fs	LUC7L3_ENST00000393227.2_Frame_Shift_Del_p.E127fs|LUC7L3_ENST00000544170.1_Frame_Shift_Del_p.E51fs|LUC7L3_ENST00000240304.1_Frame_Shift_Del_p.E127fs			O95232	LC7L3_HUMAN	LUC7-like 3 (S. cerevisiae)	127					apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	12						AAAAATGAAGAAAAAATTCAG	0.363													15	63	---	---	---	---					
WFIKKN2	124857	broad.mit.edu	37	17	48917825	48917825	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:48917825delG	ENST00000311378.4	+	2	1704	c.1176delG	c.(1174-1176)cafs	p.Q392fs	WFIKKN2_ENST00000426127.1_Frame_Shift_Del_p.Q299fs|RP11-506D12.5_ENST00000572491.2_RNA	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	392	BPTI/Kunitz inhibitor 2.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CCGCCCTGCAGGGGCCCTGCA	0.647													19	68	---	---	---	---					
HSF5	124535	broad.mit.edu	37	17	56557547	56557548	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:56557547_56557548insG	ENST00000323777.3	-	2	740_741	c.631_632insC	c.(631-633)cgafs	p.R211fs		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	211						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTGTGGTCGTGGGATGGAGTT	0.475													37	87	---	---	---	---					
MED13	9969	broad.mit.edu	37	17	60033826	60033826	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:60033826delT	ENST00000397786.2	-	24	5573	c.5497delA	c.(5497-5499)gtfs	p.S1834fs		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1834					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CTAGCAGAACTTTTTTTCCGA	0.363													20	83	---	---	---	---					
LRRC37A16P	651250	broad.mit.edu	37	17	66131476	66131476	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:66131476delC	ENST00000590019.1	-	0	298																											CGCCCAGGAGCCCCCCTGACT	0.652													8	22	---	---	---	---					
CDC42EP4	23580	broad.mit.edu	37	17	71281934	71281934	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:71281934delC	ENST00000335793.3	-	2	1100	c.706delG	c.(706-708)agfs	p.E236fs	CDC42EP4_ENST00000581014.1_Intron|CDC42EP4_ENST00000439510.2_Frame_Shift_Del_p.E166fs			Q9H3Q1	BORG4_HUMAN	CDC42 effector protein (Rho GTPase binding) 4	236					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(7)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			TAACCACCCTCCCCCTCCTCG	0.672													11	56	---	---	---	---					
SDK2	54549	broad.mit.edu	37	17	71344855	71344855	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:71344855delG	ENST00000392650.3	-	44	6048	c.6048delC	c.(6046-6048)ccfs	p.P2016fs	SDK2_ENST00000388726.3_Frame_Shift_Del_p.P1997fs|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2016					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGCTGGGCCTGGGGGGAGACC	0.657													18	68	---	---	---	---					
ATP5H	10476	broad.mit.edu	37	17	73038718	73038718	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:73038718delT	ENST00000301587.4	-	2	75	c.28delA	c.(28-30)ccfs	p.T10fs	ATP5H_ENST00000344546.4_Frame_Shift_Del_p.T10fs|KCTD2_ENST00000581589.1_Intron|KCTD2_ENST00000584767.1_Intron	NM_006356.2	NP_006347.1	O75947	ATP5H_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	10					ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			lung(1)|skin(1)	2	all_lung(278;0.226)					CAGTCAATGGTTTTTAGAGCA	0.418													59	166	---	---	---	---					
ITGB4	3691	broad.mit.edu	37	17	73725372	73725373	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:73725372_73725373insC	ENST00000200181.3	+	7	780_781	c.593_594insC	c.(592-594)gccfs	p.A198fs	ITGB4_ENST00000579662.1_Frame_Shift_Ins_p.A198fs|ITGB4_ENST00000450894.3_Frame_Shift_Ins_p.A198fs|ITGB4_ENST00000449880.2_Frame_Shift_Ins_p.A198fs|ITGB4_ENST00000339591.3_Frame_Shift_Ins_p.A198fs|ITGB4_ENST00000584558.1_3'UTR	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	198	VWFA.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity	p.D198D(1)|p.F201fs*9(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCAACAGTGACCCCCCCTTCT	0.599													32	63	---	---	---	---					
ZACN	353174	broad.mit.edu	37	17	74077706	74077707	+	Frame_Shift_Ins	INS	-	-	G	rs146722649		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr17:74077706_74077707insG	ENST00000334586.5	+	7	833_834	c.750_751insG	c.(748-753)tgggggfs	p.WG250fs	EXOC7_ENST00000332065.5_3'UTR|EXOC7_ENST00000589210.1_3'UTR|EXOC7_ENST00000607838.1_3'UTR|EXOC7_ENST00000591724.1_Intron	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	250	Leu-rich.				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						CTGACGTGTGCGGGGGGTTGCT	0.614													59	199	---	---	---	---					
RNMT	8731	broad.mit.edu	37	18	13746253	13746253	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:13746253delA	ENST00000383314.2	+	9	1414	c.1174delA	c.(1174-1176)aafs	p.K393fs	RNMT_ENST00000592764.1_Frame_Shift_Del_p.K393fs|RNMT_ENST00000535051.1_Frame_Shift_Del_p.K151fs|RNMT_ENST00000262173.3_Frame_Shift_Del_p.K393fs|RNMT_ENST00000543302.2_Frame_Shift_Del_p.K393fs|RNMT_ENST00000589866.1_Frame_Shift_Del_p.K393fs			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	393					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding	p.T394fs*19(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						ACTAGTCTACAAAAAAACATT	0.308													22	74	---	---	---	---					
TTC39C	125488	broad.mit.edu	37	18	21705516	21705517	+	Splice_Site	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:21705516_21705517insA	ENST00000540918.2	+	5	749		c.e5+2		TTC39C_ENST00000304621.6_Splice_Site|TTC39C_ENST00000317571.3_Splice_Site			Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C								binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	19						TGAGTCAAGGTAAAAAATTTAA	0.431													41	110	---	---	---	---					
OSBPL1A	114876	broad.mit.edu	37	18	21751417	21751417	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:21751417delA	ENST00000319481.3	-	23	2453	c.2247delT	c.(2245-2247)ttfs	p.F749fs	OSBPL1A_ENST00000399443.3_Frame_Shift_Del_p.F236fs|OSBPL1A_ENST00000357041.4_Frame_Shift_Del_p.F367fs	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	749					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					ATTCCTTACCAAAAAGGCCAC	0.308													37	106	---	---	---	---					
DSC2	1824	broad.mit.edu	37	18	28673608	28673609	+	Splice_Site	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:28673608_28673609insA	ENST00000280904.6	-	2	513		c.e2-2		DSC2_ENST00000251081.6_Splice_Site	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2						homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TATTAAGATCTAAAAAATGAAA	0.262													22	89	---	---	---	---					
TCEB3C	162699	broad.mit.edu	37	18	44555282	44555282	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:44555282delA	ENST00000330682.2	-	1	1167	c.932delT	c.(931-933)tcfs	p.F311fs	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	311	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GCGTCCAGGGAAAGCAGCTTC	0.642													43	1006	---	---	---	---					
ZBTB7C	201501	broad.mit.edu	37	18	45567085	45567085	+	Frame_Shift_Del	DEL	C	C	-	rs115080210	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:45567085delC	ENST00000588982.1	-	3	895	c.394delG	c.(394-396)acfs	p.D132fs	ZBTB7C_ENST00000535628.2_Frame_Shift_Del_p.D132fs|ZBTB7C_ENST00000332053.2_Frame_Shift_Del_p.D132fs|ZBTB7C_ENST00000590800.1_Frame_Shift_Del_p.D132fs|ZBTB7C_ENST00000586438.1_Frame_Shift_Del_p.D132fs			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	132	Asp-rich.|Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						tcccccccgtcccccCCAGGC	0.582													12	37	---	---	---	---					
LOC100287225	100287225	broad.mit.edu	37	18	48960171	48960171	+	RNA	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:48960171delG	ENST00000578152.1	+	0	216					NR_040075.1																						CTTGTTTCATGGGGGGCACTC	0.403													3	3	---	---	---	---					
RP11-795H16.3	0	broad.mit.edu	37	18	57817640	57817640	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:57817640delA	ENST00000588794.1	+	0	346																											TGCTATTTGTaaaaaaaataa	0.294													7	20	---	---	---	---					
TMX3	54495	broad.mit.edu	37	18	66367677	66367677	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:66367677delT	ENST00000299608.2	-	6	673	c.357delA	c.(355-357)aafs	p.K119fs	TMX3_ENST00000443099.2_Intron|TMX3_ENST00000562706.1_Frame_Shift_Del_p.K119fs	NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	119	Thioredoxin.				cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						TAATATCATCTTTTGTTCGTG	0.249													49	132	---	---	---	---					
SOCS6	9306	broad.mit.edu	37	18	67992095	67992096	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr18:67992095_67992096insA	ENST00000397942.3	+	2	507_508	c.191_192insA	c.(190-192)gaafs	p.E64fs	SOCS6_ENST00000582322.1_Frame_Shift_Ins_p.E64fs	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	64					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GAAAAAGGCGGAAAAAACAGAT	0.470													22	157	---	---	---	---					
PRSS57	400668	broad.mit.edu	37	19	694923	694923	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:694923delG	ENST00000329267.7	-	2	156	c.127delC	c.(127-129)acfs	p.H43fs		NM_214710.3	NP_999875.1	Q6UWY2	PRS57_HUMAN	protease, serine, 57	43	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|lung(5)	6						GGCCTGGAGTGGGGGGTCACC	0.701													5	11	---	---	---	---					
UHRF1	29128	broad.mit.edu	37	19	4944201	4944202	+	RNA	DEL	GA	GA	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:4944201_4944202delGA	ENST00000592666.1	+	0	1707_1708							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GAGAGCGGCTGAGAGAGAGCAA	0.653													8	28	---	---	---	---					
VAV1	7409	broad.mit.edu	37	19	6850745	6850746	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:6850745_6850746insG	ENST00000304076.2	+	23	2222_2223	c.2128_2129insG	c.(2128-2130)aaafs	p.K710fs	VAV1_ENST00000599806.1_Frame_Shift_Ins_p.K677fs|VAV1_ENST00000602142.1_Frame_Shift_Ins_p.K732fs|VAV1_ENST00000596764.1_Frame_Shift_Ins_p.K700fs|VAV1_ENST00000539284.1_Frame_Shift_Ins_p.K635fs	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	732	SH2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GATCACAGAGAAAAAGGCTTTC	0.559													21	71	---	---	---	---					
ZNF557	79230	broad.mit.edu	37	19	7083661	7083662	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7083661_7083662insA	ENST00000414706.1	+	8	1672_1673	c.1199_1200insA	c.(1198-1200)gaafs	p.E400fs	ZNF557_ENST00000439035.2_Frame_Shift_Ins_p.E393fs|ZNF557_ENST00000252840.6_Frame_Shift_Ins_p.E400fs	NM_001044387.1|NM_001044388.1|NM_024341.2	NP_001037852.1|NP_001037853.1|NP_077317.2	Q8N988	ZN557_HUMAN	zinc finger protein 557	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17				Lung(535;0.179)		ACTCACACTGGAAAAAAACCCT	0.366													22	56	---	---	---	---					
CAMSAP3	57662	broad.mit.edu	37	19	7676687	7676687	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:7676687delC	ENST00000446248.2	+	13	1490	c.1389delC	c.(1387-1389)ggfs	p.G463fs	CAMSAP3_ENST00000160298.4_Frame_Shift_Del_p.G436fs	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	436	Pro-rich.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						ACAGCCTGGGCCCCCCGCGTC	0.682													21	21	---	---	---	---					
COL5A3	50509	broad.mit.edu	37	19	10088132	10088132	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10088132delG	ENST00000264828.3	-	43	3228	c.3143delC	c.(3142-3144)ctfs	p.P1048fs		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1048	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGTGGGGCCAGGGGGGCCACG	0.662													44	151	---	---	---	---					
CTD-2369P2.5	0	broad.mit.edu	37	19	10377498	10377498	+	RNA	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:10377498delT	ENST00000592893.1	-	0	141																											TCCATAGCCCTTTTTTTTTCC	0.428													8	18	---	---	---	---					
IER2	9592	broad.mit.edu	37	19	13264483	13264484	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:13264483_13264484insC	ENST00000588173.1	+	1	1695_1696	c.483_484insC	c.(481-486)caccccfs	p.HP161fs	CTC-250I14.6_ENST00000586483.1_RNA|IER2_ENST00000292433.3_Frame_Shift_Ins_p.HP161fs|IER2_ENST00000587885.1_Frame_Shift_Ins_p.HP161fs|CTC-250I14.6_ENST00000592882.1_RNA			Q9BTL4	IER2_HUMAN	immediate early response 2	161										kidney(1)|lung(1)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			ATCGCCTGCAGCCCCCTCCGGC	0.693											OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	58	---	---	---	---					
CACNA1A	773	broad.mit.edu	37	19	13373574	13373574	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:13373574delT	ENST00000360228.5	-	25	4062	c.4063delA	c.(4063-4065)ccfs	p.T1355fs	CACNA1A_ENST00000573710.2_Frame_Shift_Del_p.T1356fs	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1356					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGCTTGATGGTTTTAAGAGGT	0.517											OREG0025294	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	26	---	---	---	---					
BRD4	23476	broad.mit.edu	37	19	15376248	15376248	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:15376248delG	ENST00000263377.2	-	5	987	c.766delC	c.(766-768)agfs	p.Q256fs	BRD4_ENST00000371835.4_Frame_Shift_Del_p.Q256fs|BRD4_ENST00000360016.5_Frame_Shift_Del_p.Q256fs	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	256					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GGTTGTGGCTGGGGGGGCACT	0.687			T	C15orf55	lethal midline carcinoma of young people								10	30	---	---	---	---					
UNC13A	23025	broad.mit.edu	37	19	17766809	17766809	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:17766809delG	ENST00000428389.2	-	11	1429	c.1430delC	c.(1429-1431)cafs	p.P477fs	UNC13A_ENST00000552293.1_Frame_Shift_Del_p.P389fs|UNC13A_ENST00000252773.7_Frame_Shift_Del_p.P389fs|UNC13A_ENST00000551649.1_Frame_Shift_Del_p.P389fs|UNC13A_ENST00000519716.2_Frame_Shift_Del_p.P389fs|UNC13A_ENST00000550896.1_Frame_Shift_Del_p.P389fs			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	389					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GGGTGCCACTGGGGCCTTGTC	0.662													9	18	---	---	---	---					
ZNF254	9534	broad.mit.edu	37	19	24310632	24310633	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:24310632_24310633insT	ENST00000357002.4	+	4	1945_1946	c.1830_1831insT	c.(1828-1833)gcttttfs	p.AF610fs	ZNF254_ENST00000342944.6_Frame_Shift_Ins_p.AF525fs	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	610					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GTGGCAAAGCATTTTTCTGGTC	0.376													18	82	---	---	---	---					
ZNF507	22847	broad.mit.edu	37	19	32843909	32843909	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:32843909delA	ENST00000311921.3	+	2	365	c.173delA	c.(172-174)gafs	p.E58fs	ZNF507_ENST00000587084.1_3'UTR|ZNF507_ENST00000355898.5_Frame_Shift_Del_p.E58fs|ZNF507_ENST00000544431.1_Frame_Shift_Del_p.E58fs	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					GTGGAAAATGAAAAGTCACAA	0.368													15	52	---	---	---	---					
ZNF792	126375	broad.mit.edu	37	19	35450469	35450470	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:35450469_35450470insA	ENST00000404801.1	-	4	675_676	c.289_290insT	c.(289-291)ccafs	p.P97fs	ZNF792_ENST00000605484.1_Frame_Shift_Ins_p.P30fs	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGTTCCATGGCAAAAATCTGAA	0.480													17	51	---	---	---	---					
KMT2B	9757	broad.mit.edu	37	19	36222938	36222938	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:36222938delC	ENST00000222270.7	+	27	5567	c.5567delC	c.(5566-5568)gcfs	p.A1856fs	WBP7_ENST00000420124.1_Frame_Shift_Del_p.A1856fs|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					CCTCCTCCAGCCCCCCGTTCT	0.642													10	20	---	---	---	---					
RYR1	6261	broad.mit.edu	37	19	39025414	39025415	+	Frame_Shift_Ins	INS	-	-	G			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:39025414_39025415insG	ENST00000355481.4	+	78	11430_11431	c.11299_11300insG	c.(11299-11301)gggfs	p.G3767fs	RYR1_ENST00000359596.3_Frame_Shift_Ins_p.G3772fs|RYR1_ENST00000360985.3_Frame_Shift_Ins_p.G3772fs	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3772					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGCACACCCGGGGGGCGGCC	0.589													21	44	---	---	---	---					
LGALS17A	400696	broad.mit.edu	37	19	40172017	40172017	+	RNA	DEL	G	G	-	rs28457128	by1000genomes	TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:40172017delG	ENST00000412609.1	+	0	61																											AATCTGTTACGGGGGGGAGGC	0.587													8	10	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42794869	42794869	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:42794869delC	ENST00000572681.2	+	11	4744	c.4676delC	c.(4675-4677)gcfs	p.A1559fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.A650fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.A650fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	650	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GTGCCCTCCGCCCCCGCCCCA	0.682			"""Mis, F, S"""		oligodendroglioma								13	37	---	---	---	---					
GLTSCR1	29998	broad.mit.edu	37	19	48197891	48197891	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:48197891delC	ENST00000396720.3	+	8	2997	c.2803delC	c.(2803-2805)ccfs	p.P940fs	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	940	Poly-Pro.						protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GCCGGCAGCACCCCCCCCACC	0.672													9	29	---	---	---	---					
BCL2L12	83596	broad.mit.edu	37	19	50173670	50173670	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50173670delG	ENST00000246785.3	+	6	1137	c.879delG	c.(877-879)ctfs	p.L293fs	BCL2L12_ENST00000441864.2_Frame_Shift_Del_p.L292fs|BCL2L12_ENST00000246784.3_3'UTR	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)	293					apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		TGGCCGGGCTGGGGGGCACCC	0.751													4	8	---	---	---	---					
SIGLEC16	400709	broad.mit.edu	37	19	50475431	50475431	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:50475431delC	ENST00000602139.1	+	0	1304									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						TCCCACAGAGCCCCCCCAGCT	0.682													9	33	---	---	---	---					
ZNF880	400713	broad.mit.edu	37	19	52877717	52877717	+	Frame_Shift_Del	DEL	T	T	-	rs77187934		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:52877717delT	ENST00000597976.1	+	3	325	c.305delT	c.(304-306)atfs	p.I102fs	ZNF880_ENST00000424032.2_Intron|ZNF880_ENST00000422689.2_Intron|ZNF880_ENST00000600321.1_Intron|ZNF880_ENST00000344085.5_Intron			Q6PDB4	ZN880_HUMAN	zinc finger protein 880	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						GGCCCCATAAttttttttttt	0.473													9	12	---	---	---	---					
ZNF264	9422	broad.mit.edu	37	19	57705383	57705384	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:57705383_57705384insC	ENST00000599653.1	+	2	551_552	c.174_175insC	c.(172-177)ctccccfs	p.LP58fs	ZNF264_ENST00000536056.1_Intron|ZNF264_ENST00000600531.1_Intron|ZNF264_ENST00000263095.6_Intron			O43296	ZN264_HUMAN	zinc finger protein 264	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	27		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		AGGCCTTCCTTCCCCCTCCACC	0.579													22	105	---	---	---	---					
ZNF749	388567	broad.mit.edu	37	19	57954687	57954687	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:57954687delG	ENST00000334181.4	+	3	421	c.171delG	c.(169-171)gafs	p.E57fs	AC004076.9_ENST00000596831.1_Intron	NM_001023561.2	NP_001018855.2	O43361	ZN749_HUMAN	zinc finger protein 749	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|lung(3)|prostate(1)	13		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		AGGATGAGGAGGTACCTTCCA	0.512													17	59	---	---	---	---					
ZNF773	374928	broad.mit.edu	37	19	58018055	58018055	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58018055delA	ENST00000282292.4	+	4	732	c.592delA	c.(592-594)aafs	p.K198fs	ZNF773_ENST00000593916.1_Intron|ZNF773_ENST00000599847.1_Intron|ZNF773_ENST00000598770.1_Frame_Shift_Del_p.K197fs	NM_198542.1	NP_940944.1	Q6PK81	ZN773_HUMAN	zinc finger protein 773	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		TGAATGTGGGAAAGCCTTTGG	0.453													29	74	---	---	---	---					
ZNF417	147687	broad.mit.edu	37	19	58420945	58420945	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr19:58420945delA	ENST00000312026.5	-	3	865	c.701delT	c.(700-702)tcfs	p.F234fs	ZNF417_ENST00000595559.1_Frame_Shift_Del_p.F233fs|ZNF417_ENST00000536263.1_Frame_Shift_Del_p.F35fs|CTD-2583A14.9_ENST00000602124.1_Intron	NM_152475.2	NP_689688.2	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|stomach(3)|upper_aerodigestive_tract(1)	18		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		ATCTCTAGTGAAAAGTTTCTG	0.428													24	114	---	---	---	---					
SLC23A2	9962	broad.mit.edu	37	20	4864378	4864378	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:4864378delA	ENST00000379333.1	-	9	1126	c.734delT	c.(733-735)tgfs	p.L245fs	SLC23A2_ENST00000424750.2_Intron|SLC23A2_ENST00000468355.1_5'UTR|SLC23A2_ENST00000338244.1_Frame_Shift_Del_p.L245fs	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	245					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGTAATGGTCAAGGGACCGAT	0.577													20	93	---	---	---	---					
ZNF133	7692	broad.mit.edu	37	20	18287008	18287008	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:18287008delA	ENST00000377671.3	+	6	747	c.188delA	c.(187-189)gafs	p.E63fs	ZNF133_ENST00000538547.1_Intron|ZNF133_ENST00000535822.1_5'UTR|ZNF133_ENST00000316358.4_Frame_Shift_Del_p.E63fs|ZNF133_ENST00000402618.2_5'UTR|ZNF133_ENST00000396026.3_Frame_Shift_Del_p.E66fs|ZNF133_ENST00000401790.1_Frame_Shift_Del_p.E63fs	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	63	KRAB.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						TGGAGAGAGGAAAAAAAATGT	0.473													10	21	---	---	---	---					
TP53INP2	58476	broad.mit.edu	37	20	33296605	33296606	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:33296605_33296606insC	ENST00000374810.3	+	3	451_452	c.62_63insC	c.(61-63)tccfs	p.S21fs	NCOA6_ENST00000593786.1_Intron|TP53INP2_ENST00000374809.2_Frame_Shift_Ins_p.S21fs	NM_021202.1	NP_067025.1	Q8IXH6	T53I2_HUMAN	tumor protein p53 inducible nuclear protein 2	21						nucleus				endometrium(1)|urinary_tract(1)	2						GACCCCGACTGCCCCCGCGCCT	0.668													11	32	---	---	---	---					
RALGAPB	57148	broad.mit.edu	37	20	37177336	37177336	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:37177336delT	ENST00000262879.6	+	20	3191	c.2907delT	c.(2905-2907)gafs	p.D969fs	RALGAPB_ENST00000397042.3_Frame_Shift_Del_p.D965fs|RALGAPB_ENST00000397038.1_Frame_Shift_Del_p.D747fs|RALGAPB_ENST00000397040.1_Frame_Shift_Del_p.D969fs			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	969					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.F971fs*53(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTCTAGATGATTTTTTCCCCT	0.378													17	40	---	---	---	---					
ZNF334	55713	broad.mit.edu	37	20	45131105	45131106	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:45131105_45131106delTC	ENST00000457685.2	-	6	2081_2082	c.758_759delGA	c.(757-759)afs	p.R253fs	ZNF334_ENST00000347606.4_Frame_Shift_Del_p.R291fs|ZNF334_ENST00000593880.1_Frame_Shift_Del_p.R314fs			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ATTCATAGGGTCTCTCTCCAGT	0.416													34	126	---	---	---	---					
DIDO1	11083	broad.mit.edu	37	20	61513712	61513713	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr20:61513712_61513713insT	ENST00000266070.4	-	16	3920_3921	c.3595_3596insA	c.(3595-3597)caafs	p.Q1199fs	DIDO1_ENST00000395343.1_Frame_Shift_Ins_p.Q1199fs	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1199					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GGGACGTTTGATTTTTTGGCAG	0.431													27	92	---	---	---	---					
DOPEY2	9980	broad.mit.edu	37	21	37660372	37660372	+	Frame_Shift_Del	DEL	T	T	-	rs34641375		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:37660372delT	ENST00000399151.3	+	33	6306	c.6221delT	c.(6220-6222)ctfs	p.L2074fs		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	2074					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CAGATGTTTCTTTTTTTCAGA	0.373													7	137	---	---	---	---					
C21orf33	8209	broad.mit.edu	37	21	45555967	45555967	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45555967delG	ENST00000291577.6	+	3	313	c.220delG	c.(220-222)ggfs	p.G74fs	C21orf33_ENST00000493883.1_3'UTR|C21orf33_ENST00000427803.2_Frame_Shift_Del_p.G74fs|C21orf33_ENST00000348499.5_Frame_Shift_Del_p.G74fs	NM_004649.6	NP_004640.3	P30042	ES1_HUMAN	chromosome 21 open reading frame 33	74						mitochondrion				NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8				STAD - Stomach adenocarcinoma(101;0.168)|Colorectal(79;0.191)		GAGCCGTGGAGGGGCTGAAGT	0.552													9	30	---	---	---	---					
KRTAP10-5	386680	broad.mit.edu	37	21	45999955	45999955	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr21:45999955delG	ENST00000400372.1	-	1	526	c.501delC	c.(499-501)ccfs	p.P167fs	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	167	22 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						ACTGCTGGCAGGGGGAGGAGG	0.597													103	359	---	---	---	---					
CCT8L2	150160	broad.mit.edu	37	22	17071787	17071787	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:17071787delT	ENST00000359963.3	-	1	1913	c.1654delA	c.(1654-1656)tcfs	p.I552fs		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	552					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AATCCAAGGATTTTTTTTGTT	0.408													24	95	---	---	---	---					
P2RX6P	440799	broad.mit.edu	37	22	21399221	21399221	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:21399221delC	ENST00000439119.1	-	0	51					NR_002829.1																						CTGCAGGGCGCCCCCCCACCA	0.597													62	165	---	---	---	---					
GGT5	2687	broad.mit.edu	37	22	24622210	24622210	+	Frame_Shift_Del	DEL	C	C	-	rs144862235		TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:24622210delC	ENST00000327365.4	-	8	1479	c.1063delG	c.(1063-1065)agfs	p.E355fs	GGT5_ENST00000263112.7_Frame_Shift_Del_p.E323fs|GGT5_ENST00000398292.3_Frame_Shift_Del_p.E355fs|GGT5_ENST00000418439.2_Frame_Shift_Del_p.E278fs	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	355					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						GCCAGGGTCTCCCCCAGCAGG	0.677													33	55	---	---	---	---					
GAS2L1	10634	broad.mit.edu	37	22	29707852	29707852	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:29707852delC	ENST00000471961.1	+	5	2459	c.1411delC	c.(1411-1413)ccfs	p.P472fs	GAS2L1_ENST00000407854.1_Frame_Shift_Del_p.P472fs|GAS2L1_ENST00000407647.2_Frame_Shift_Del_p.P472fs|GAS2L1_ENST00000406549.3_Intron|GAS2L1_ENST00000403764.1_Frame_Shift_Del_p.P472fs|GAS2L1_ENST00000360113.2_3'UTR|GAS2L1_ENST00000341313.6_3'UTR			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	475					cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						GGCAGGAGCACCCCCCAGACT	0.711													8	24	---	---	---	---					
SUN2	25777	broad.mit.edu	37	22	39135892	39135893	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:39135892_39135893insC	ENST00000405510.1	-	14	1770_1771	c.1412_1413insG	c.(1411-1413)gcgfs	p.A471fs	SUN2_ENST00000406622.1_Frame_Shift_Ins_p.A471fs|SUN2_ENST00000216064.4_Frame_Shift_Ins_p.A471fs|SUN2_ENST00000411587.2_Frame_Shift_Ins_p.A460fs|RP3-508I15.14_ENST00000416406.1_RNA|SUN2_ENST00000405018.1_Frame_Shift_Ins_p.A492fs	NM_001199580.1	NP_001186509.1	Q9UH99	SUN2_HUMAN	Sad1 and UNC84 domain containing 2	471	Poly-Gly.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)|stomach(1)	15						GCCCCACGCGGCCCCCTCCACC	0.619													48	247	---	---	---	---					
ZC3H7B	23264	broad.mit.edu	37	22	41752381	41752382	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:41752381_41752382insA	ENST00000352645.4	+	21	2675_2676	c.2418_2419insA	c.(2416-2421)ctaaaafs	p.LK806fs	ZC3H7B_ENST00000351589.4_Frame_Shift_Ins_p.LK806fs	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	822					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACATGTGGCTGAAAAAACACAA	0.589													58	231	---	---	---	---					
PHF5A	84844	broad.mit.edu	37	22	41856422	41856423	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:41856422_41856423insT	ENST00000216252.3	-	4	383_384	c.312_313insA	c.(310-315)aaacggfs	p.R105fs		NM_032758.3	NP_116147.1	Q7RTV0	PHF5A_HUMAN	PHD finger protein 5A	105					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent	nuclear speck|U12-type spliceosomal complex|U2 snRNP	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(1)	4						TTGAAGCCGTATTTTTTGCGTT	0.485													18	146	---	---	---	---					
XRCC6	2547	broad.mit.edu	37	22	42024155	42024155	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:42024155delT	ENST00000359308.4	+	2	771	c.116delT	c.(115-117)atfs	p.I39fs	XRCC6_ENST00000405506.1_Intron|XRCC6_ENST00000360079.3_Frame_Shift_Del_p.I39fs|XRCC6_ENST00000405878.1_Frame_Shift_Del_p.I39fs|XRCC6_ENST00000402580.3_Frame_Shift_Del_p.I39fs|XRCC6_ENST00000428575.2_Intron			P12956	XRCC6_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 6	39	Ser-rich (potentially targets for phosphorylation).				DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	31						GATAGTTTGATTTTTTTGGTT	0.333								Non-homologous end-joining					20	88	---	---	---	---					
SERHL	94009	broad.mit.edu	37	22	42898666	42898666	+	RNA	DEL	C	C	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chr22:42898666delC	ENST00000359906.2	+	0	409					NR_027786.1				serine hydrolase-like											endometrium(1)|large_intestine(1)	2						CCATATGGTGCCCCCCCCCCA	0.592													7	9	---	---	---	---					
SLC25A6	293	broad.mit.edu	37	X	1508487	1508487	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:1508487delA	ENST00000381401.5	-	2	959	c.245delT	c.(244-246)tcfs	p.F82fs	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	82					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	TTGAGTGGGGAAGTAGCGAAT	0.572													10	364	---	---	---	---					
OFD1	8481	broad.mit.edu	37	X	13764946	13764946	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:13764946delA	ENST00000380567.1	+	9	1154	c.282delA	c.(280-282)gcfs	p.A94fs	OFD1_ENST00000340096.6_Frame_Shift_Del_p.A234fs|OFD1_ENST00000380550.3_Frame_Shift_Del_p.A234fs|OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000398395.3_Frame_Shift_Del_p.A234fs			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	234	LisH.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						AAATGGAAGCAAAAAAAAAGT	0.299													31	29	---	---	---	---					
NHS	4810	broad.mit.edu	37	X	17746019	17746019	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:17746019delA	ENST00000380060.3	+	6	4068	c.3730delA	c.(3730-3732)aafs	p.K1244fs	NHS_ENST00000398097.3_Frame_Shift_Del_p.K1088fs	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1244						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CACGCCAACCAAAAACTGTGC	0.443													46	55	---	---	---	---					
XK	7504	broad.mit.edu	37	X	37587562	37587562	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:37587562delT	ENST00000378616.3	+	3	1385	c.1182delT	c.(1180-1182)tgfs	p.C394fs	TM4SF2_ENST00000465127.1_Intron	NM_021083.2	NP_066569.1	P51811	XK_HUMAN	X-linked Kx blood group (McLeod syndrome)	394					amino acid transport	integral to membrane	protein binding|transporter activity			breast(1)|endometrium(4)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		all_lung(315;0.175)				GGCTCAGGTGTTTTTGCTGGG	0.458													24	30	---	---	---	---					
CLCN5	1184	broad.mit.edu	37	X	49840518	49840518	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:49840518delG	ENST00000376088.3	+	7	1125	c.484delG	c.(484-486)ggfs	p.G163fs	CLCN5_ENST00000307367.2_Frame_Shift_Del_p.G93fs|CLCN5_ENST00000376108.3_Frame_Shift_Del_p.G93fs|CLCN5_ENST00000376091.3_Frame_Shift_Del_p.G163fs	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	93					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					TATATGCACAGGGGGATTCTG	0.458													34	38	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73045191	73045191	+	RNA	DEL	T	T	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:73045191delT	ENST00000604411.1	+	0	33152				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GAAAGAGCACTTTTTTATGCT	0.328													16	16	---	---	---	---					
XIST	7503	broad.mit.edu	37	X	73071846	73071846	+	RNA	DEL	A	A	-			TCGA-F7-A624-01A-22D-A30E-08	TCGA-F7-A624-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e11fa84c-c4e9-41bc-8b46-48be0444880a	91726c6b-a3b7-4cbc-9e8f-990a0824147e	g.chrX:73071846delA	ENST00000429829.1	-	0	742					NR_001564.2																						ATGGGCGATGAAAAAAAAAAA	0.413													6	10	---	---	---	---