Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TUBGCP6	85378	broad.mit.edu	37	22	50682173	50682173	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr22:50682173G>A	ENST00000439308.2	-	1	1208	c.716C>T	c.(715-717)gCg>gTg	p.A239V	TUBGCP6_ENST00000248846.5_Missense_Mutation_p.A239V	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	239					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGAGAGGTCCGCATTGTCTGG	0.542000													4	74					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228505307	228505307	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:228505307G>T	ENST00000570156.2	+	63	16649	c.16575G>T	c.(16573-16575)caG>caT	p.Q5525H	OBSCN_ENST00000284548.11_Missense_Mutation_p.Q4568H|OBSCN_ENST00000422127.1_Missense_Mutation_p.Q4568H|OBSCN_ENST00000366707.4_Missense_Mutation_p.Q2202H|OBSCN_ENST00000366709.4_Missense_Mutation_p.Q1687H	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4568					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCACAGGCCAGTGGCGGCTGT	0.677000													21	34					2.27731e-05	2.38161e-05	1	1	0
RALGAPA2	57186	broad.mit.edu	37	20	20618015	20618015	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr20:20618015G>A	ENST00000202677.6	-	8	939	c.797C>T	c.(796-798)cCt>cTt	p.P266L		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	266					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						ACCAAGTACAGGTTTGTAGAT	0.303000													3	15					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667777	49667777	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:49667777C>T	ENST00000249601.4	-	5	905	c.609G>A	c.(607-609)gtG>gtA	p.V203V	ARHGAP22_ENST00000435790.2_Silent_p.V209V|ARHGAP22_ENST00000374172.1_Silent_p.V94V|ARHGAP22_ENST00000374170.1_Silent_p.V113V|ARHGAP22_ENST00000417912.2_Silent_p.V219V|ARHGAP22_ENST00000417247.2_Silent_p.V113V	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	203	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCAGGTCCCTCACCAGGTTGG	0.627000													85	170					0	0	1	0	0
CST9L	128821	broad.mit.edu	37	20	23546710	23546710	+	Silent	SNP	A	A	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr20:23546710A>T	ENST00000376979.3	-	2	553	c.255T>A	c.(253-255)acT>acA	p.T85T		NM_080610.2	NP_542177.1	Q9H4G1	CST9L_HUMAN	cystatin 9-like	85						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8	Colorectal(13;0.0431)|Lung NSC(19;0.235)					TTGAGAATACAGTCTTGGACT	0.458000													45	166					0	0	1	0	0
PEX11B	8799	broad.mit.edu	37	1	145522769	145522769	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:145522769C>T	ENST00000369306.3	+	4	779	c.630C>T	c.(628-630)gaC>gaT	p.D210D	PEX11B_ENST00000537888.1_Silent_p.D196D	NM_003846.2	NP_003837.1	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	210					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCTGCTAGACGTGGTCAGAA	0.582000													45	93					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172674530	172674530	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr3:172674530T>A	ENST00000351008.3	-	6	1201	c.1018A>T	c.(1018-1020)Ata>Tta	p.I340L		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	340					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			ACTTTTTCTATTTTATCAGCT	0.358000													14	38					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44324289	44324289	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr21:44324289C>T	ENST00000354250.2	+	3	1236	c.1167C>T	c.(1165-1167)caC>caT	p.H389H	NDUFV3_ENST00000340344.3_Intron|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AGAATAACCACGGTTTCCATG	0.572000													8	31					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33956091	33956091	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr9:33956091G>C	ENST00000379238.1	-	11	969	c.852C>G	c.(850-852)atC>atG	p.I284M	UBAP2_ENST00000539807.1_Missense_Mutation_p.I39M|UBAP2_ENST00000418786.2_Missense_Mutation_p.I231M|UBAP2_ENST00000449054.1_Missense_Mutation_p.I284M|UBAP2_ENST00000379239.4_Intron|UBAP2_ENST00000360802.1_Missense_Mutation_p.I284M			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	284										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GCCCAGGTAAGATGTGATTCT	0.338000													18	187					0	0	1	0	0
HPR	3250	broad.mit.edu	37	16	72110962	72110962	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr16:72110962G>T	ENST00000540303.2	+	5	1061	c.1029G>T	c.(1027-1029)aaG>aaT	p.K343N	HPR_ENST00000561690.1_3'UTR|HPR_ENST00000228226.8_Missense_Mutation_p.K380N|HPR_ENST00000356967.5_Missense_Mutation_p.K343N	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	343	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				GGGTTCAGAAGACCATAGCTG	0.537000													9	60					0.000673444	0.000688521	1	1	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	58					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240601385	240601385	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:240601385C>G	ENST00000319653.9	+	16	5165	c.4935C>G	c.(4933-4935)ttC>ttG	p.F1645L	FMN2_ENST00000545751.1_Missense_Mutation_p.F241L	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1645	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGGCATATTTCTTCATGAAAC	0.383000													37	90					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50280430	50280430	+	Silent	SNP	C	C	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr2:50280430C>G	ENST00000404971.1	-	22	5566	c.4227G>C	c.(4225-4227)ccG>ccC	p.P1409P	NRXN1_ENST00000342183.5_Silent_p.P304P|NRXN1_ENST00000406316.2_Silent_p.P1339P|NRXN1_ENST00000401669.2_Silent_p.P1369P|NRXN1_ENST00000402717.3_Silent_p.P1361P|NRXN1_ENST00000401710.1_Silent_p.P357P|NRXN1_ENST00000406859.3_Silent_p.P1339P|NRXN1_ENST00000405472.3_Silent_p.P1361P	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1339	Poly-Ala.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GTTCTTTTGTCGGGGGCTTTC	0.453000													32	83					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62551060	62551060	+	Silent	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr14:62551060C>A	ENST00000430451.2	+	5	1778	c.1581C>A	c.(1579-1581)atC>atA	p.I527I		NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	527	C2 2.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TGGAAATGATCAAAGGCAGCC	0.547000													18	35					3.52763e-06	3.71758e-06	1	1	0
MNX1	3110	broad.mit.edu	37	7	156798412	156798412	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:156798412C>T	ENST00000252971.6	-	3	1308	c.1008G>A	c.(1006-1008)ccG>ccA	p.P336P	MNX1_ENST00000543409.1_Silent_p.P124P|MNX1_ENST00000469500.1_Intron	NM_005515.3	NP_005506.3	P50219	MNX1_HUMAN	motor neuron and pancreas homeobox 1	336					humoral immune response|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(4)|skin(1)	7	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGGCGCTGGCGGCCCCAGCA	0.731000													3	22					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013323	107013323	+	RNA	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr14:107013323C>T	ENST00000390625.2	-	0	126																											TCCCCTCACACTCAGTATCTC	0.463000													21	88					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68864658	68864658	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr8:68864658G>A	ENST00000288368.4	+	1	306	c.29G>A	c.(28-30)cGc>cAc	p.R10H	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	10					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GGAGACAGCCGCGCCGAGAGC	0.736000													10	7					0	0	1	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26671444	26671444	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:26671444G>A	ENST00000226225.2	+	7	1036	c.769G>A	c.(769-771)Gag>Aag	p.E257K	TNFAIP1_ENST00000544907.2_Missense_Mutation_p.E153K|TNFAIP1_ENST00000583213.1_3'UTR	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	257					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CCTACTCTATGAGACTCCCCG	0.562000													22	49					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835454	247835454	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:247835454C>T	ENST00000359688.2	-	1	911	c.890G>A	c.(889-891)gGa>gAa	p.G297E	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTTCCTAATTCCTGCCTGCAT	0.423000													26	55					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62647983	62647983	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:62647983C>T	ENST00000337910.5	-	6	1780	c.1443G>A	c.(1441-1443)aaG>aaA	p.K481K	RHOBTB1_ENST00000357917.4_Silent_p.K481K	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	481					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGAACGTTCCCTTGCTGAGAC	0.473000													3	35					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	4					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148703001	148703001	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:148703001C>A	ENST00000286091.4	-	8	1508	c.1276G>T	c.(1276-1278)Gat>Tat	p.D426Y		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	426					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			GCTCTGTAATCAAAGCTGAAG	0.627000											OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	20					3.32936e-07	3.56345e-07	1	1	0
KIF13A	63971	broad.mit.edu	37	6	17764436	17764436	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr6:17764436C>T	ENST00000378814.5	-	37	5178	c.5179G>A	c.(5179-5181)Gat>Aat	p.D1727N	KIF13A_ENST00000259711.6_Missense_Mutation_p.D1775N|KIF13A_ENST00000378816.5_Missense_Mutation_p.D1740N|KIF13A_ENST00000378843.2_Missense_Mutation_p.D1727N|KIF13A_ENST00000378826.2_Missense_Mutation_p.D1740N	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1775					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TGGAGCCCATCGGAGACAGTC	0.483000													9	25					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V|FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													7	80					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128879212	128879212	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chrX:128879212G>A	ENST00000371106.3	+	4	460	c.268G>A	c.(268-270)Gcg>Acg	p.A90T	XPNPEP2_ENST00000371105.3_Missense_Mutation_p.A90T	NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	90					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						CGAGAGGCGTGCGTGGATTAC	0.493000													18	20					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132206202	132206202	+	Splice_Site	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr6:132206202C>T	ENST00000360971.2	+	23	2463	c.2444_splice	c.e23+1	p.Q815_splice		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	815	Nuclease.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	GAATCTGAGGCAGTAAGAACA	0.378000													10	18					0	0	1	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48517558	48517558	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr19:48517558G>C	ENST00000339841.2	+	3	379	c.201G>C	c.(199-201)caG>caC	p.Q67H	ELSPBP1_ENST00000597519.1_Intron	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	67	Fibronectin type-II 1.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		AGTACTGCCAGAGTGAAGGTG	0.473000													8	70					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1231206	1231206	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr19:1231206C>T	ENST00000590083.1	-	9	1340	c.1048G>A	c.(1048-1050)Gat>Aat	p.D350N	C19orf26_ENST00000215376.6_Missense_Mutation_p.D344N|C19orf26_ENST00000382477.2_Missense_Mutation_p.D370N			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	370						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGGGGCATCCCCCTCCTCC	0.711000										HNSCC(14;0.022)			21	78					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113662509	113662509	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr8:113662509T>C	ENST00000297405.5	-	19	3318	c.3074A>G	c.(3073-3075)gAt>gGt	p.D1025G	CSMD3_ENST00000352409.3_Missense_Mutation_p.D1025G|CSMD3_ENST00000455883.2_Missense_Mutation_p.D921G|CSMD3_ENST00000343508.3_Missense_Mutation_p.D985G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1025	Sushi 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AATGGAGAAATCATGACCATA	0.428000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			86	85					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7574018	7574018	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:7574018G>A	ENST00000269305.4	-	10	1198	c.1009C>T	c.(1009-1011)Cgc>Tgc	p.R337C	TP53_ENST00000455263.2_3'UTR|TP53_ENST00000359597.4_Intron|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R337C|TP53_ENST00000420246.2_3'UTR	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	337	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(18)|p.0?(8)|p.R337fs*8(2)|p.R337G(1)|p.?(1)|p.I332fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTCGAAGCGCTCACGCCCA	0.522000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	19					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129739790	129739790	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr11:129739790C>T	ENST00000446488.3	-	23	3233	c.3130G>A	c.(3130-3132)Gtg>Atg	p.V1044M	NFRKB_ENST00000304521.5_Missense_Mutation_p.V1044M|NFRKB_ENST00000524794.1_Missense_Mutation_p.V1069M|NFRKB_ENST00000524746.1_Missense_Mutation_p.V1044M	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1044					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TCAGGAGTCACTTTGACCACA	0.537000													17	57					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79581668	79581668	+	Silent	SNP	T	T	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:79581668T>A	ENST00000372391.2	-	15	2579	c.2574A>T	c.(2572-2574)ccA>ccT	p.P858P	DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	858					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTGGGGGGCCTGGCTCCTTCC	0.592000													24	46					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158813850	158813850	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:158813850G>A	ENST00000368141.4	+	4	769	c.508G>A	c.(508-510)Gtg>Atg	p.V170M		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	170					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					ATCTGCAGCTGTGGATCATCC	0.478000													66	152					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2165590	2165590	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr16:2165590G>A	ENST00000262304.4	-	10	2094	c.1886C>T	c.(1885-1887)tCc>tTc	p.S629F	PKD1_ENST00000423118.1_Missense_Mutation_p.S629F	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	629					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTTGTCCGGGGACCTGCTCTC	0.692000													5	2					0	0	1	0	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394318	39394318	+	Silent	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:39394318T>C	ENST00000254072.6	+	1	22	c.15T>C	c.(13-15)tgT>tgC	p.C5C		NM_031963.2	NP_114169.2	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9-8	5						keratin filament				lung(8)|ovary(1)|prostate(1)	10		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCCACTGTTGTTCCCCTTGCT	0.572000													11	106					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22035601	22035601	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr22:22035601C>T	ENST00000406385.1	+	7	369	c.309C>T	c.(307-309)tgC>tgT	p.C103C	PPIL2_ENST00000398831.3_Silent_p.C103C|PPIL2_ENST00000456792.2_Silent_p.C82C|PPIL2_ENST00000335025.7_Silent_p.C103C|PPIL2_ENST00000412327.1_Silent_p.C103C|PPIL2_ENST00000492445.2_Silent_p.C103C			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	103					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					AGTACCACTGCCCAGTGCTGT	0.607000													15	46					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76449525	76449525	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:76449525C>T	ENST00000389840.5	-	65	10511	c.10387G>A	c.(10387-10389)Gcc>Acc	p.A3463T	DNAH17_ENST00000585328.1_Missense_Mutation_p.A3472T|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCGAGATGGCCTGCTCGATG	0.597000													4	42					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129171431	129171431	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chrX:129171431C>T	ENST00000540052.1	+	8	4439	c.4395C>T	c.(4393-4395)tcC>tcT	p.S1465S	BCORL1_ENST00000303743.5_Silent_p.S1539S|BCORL1_ENST00000218147.7_Silent_p.S1465S|BCORL1_ENST00000359304.2_Silent_p.S1335S	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1465					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						AGGCTTGTTCCCGGGGCTGGA	0.592000													35	31					0	0	1	0	0
CIZ1	25792	broad.mit.edu	37	9	130941438	130941438	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr9:130941438A>T	ENST00000538431.1	-	8	1295	c.1048T>A	c.(1048-1050)Tct>Act	p.S350T	CIZ1_ENST00000372954.1_Missense_Mutation_p.S326T|CIZ1_ENST00000372938.5_Missense_Mutation_p.S350T|CIZ1_ENST00000476727.2_Intron|CIZ1_ENST00000277465.4_Missense_Mutation_p.S350T|CIZ1_ENST00000325721.8_Missense_Mutation_p.S321T|CIZ1_ENST00000393608.1_Missense_Mutation_p.S350T|CIZ1_ENST00000372948.3_Missense_Mutation_p.S350T|CIZ1_ENST00000357558.5_Missense_Mutation_p.S350T|CIZ1_ENST00000541172.1_Missense_Mutation_p.S249T	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	350	Gln-rich.					nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						TGCTCTGGAGAGGTCTGTGTT	0.612000													53	81					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100266156	100266156	+	RNA	SNP	C	C	T	rs78241133		TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr4:100266156C>T	ENST00000510055.1	-	0	604				ADH1C_ENST00000515683.1_RNA			P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AAGGTGCTGACGCCGACGAAG	0.577000													30	92					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87591012	87591012	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr8:87591012C>G	ENST00000320005.5	-	17	2055	c.2008G>C	c.(2008-2010)Gaa>Caa	p.E670Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	670					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GGTGTCTCTTCTTTCGGTGGG	0.468000													69	77					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51255079	51255079	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr2:51255079G>C	ENST00000404971.1	-	2	1672	c.333C>G	c.(331-333)gaC>gaG	p.D111E	NRXN1_ENST00000406316.2_Missense_Mutation_p.D111E|NRXN1_ENST00000401669.2_Missense_Mutation_p.D111E|NRXN1_ENST00000402717.3_Missense_Mutation_p.D111E|NRXN1_ENST00000405581.1_Missense_Mutation_p.D111E|NRXN1_ENST00000406859.3_Missense_Mutation_p.D111E|NRXN1_ENST00000405472.3_Missense_Mutation_p.D111E	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	111	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.D111D(3)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCCAGGCGCCGTCGTTAACCG	0.662000													15	33					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94043232	94043232	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr5:94043232G>T	ENST00000515393.1	-	23	2968	c.2969C>A	c.(2968-2970)cCa>cAa	p.P990Q	MCTP1_ENST00000312216.8_Missense_Mutation_p.P769Q|MCTP1_ENST00000514040.1_Intron|ANKRD32_ENST00000493934.1_Intron|MCTP1_ENST00000505078.1_Missense_Mutation_p.P506Q|MCTP1_ENST00000429576.2_Missense_Mutation_p.P683Q	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	990					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TCTTTTATATGGGCTATGAGA	0.453000													31	42					6.97489e-18	7.89719e-18	1	1	0
KCNB2	9312	broad.mit.edu	37	8	73480018	73480018	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr8:73480018A>G	ENST00000523207.1	+	2	637	c.49A>G	c.(49-51)Aca>Gca	p.T17A		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	17					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TTCAAGGTCGACACTTTCCCT	0.512000													97	95					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486859	125486859	+	Silent	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr9:125486859G>A	ENST00000259466.1	+	1	591	c.591G>A	c.(589-591)caG>caA	p.Q197Q		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						CCTCCAGCCAGATGGTGGTGA	0.502000													48	402					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14634098	14634098	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:14634098C>G	ENST00000544627.1	+	13	3603	c.3283C>G	c.(3283-3285)Cgg>Ggg	p.R1095G	ATF7IP_ENST00000543189.1_Missense_Mutation_p.R1086G|ATF7IP_ENST00000540793.1_Missense_Mutation_p.R1087G|ATF7IP_ENST00000261168.4_Missense_Mutation_p.R1087G|ATF7IP_ENST00000536444.1_Missense_Mutation_p.R1086G			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	1087					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TCCTGCTGTTCGGCAGGTCAA	0.458000													12	67					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6559495	6559495	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:6559495C>A	ENST00000266557.3	+	3	654	c.425C>A	c.(424-426)cCc>cAc	p.P142H	CD27-AS1_ENST00000399492.2_RNA|CD27-AS1_ENST00000545339.1_RNA|CD27_ENST00000541233.1_3'UTR	NM_001242.4	NP_001233.1	P26842	CD27_HUMAN	CD27 molecule	142					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						CACCCTCAGCCCACCCACTTA	0.602000													34	92					1.07637e-12	1.1797e-12	1	1	0
EFCAB12	90288	broad.mit.edu	37	3	129140502	129140502	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr3:129140502T>C	ENST00000505956.1	-	2	356	c.194A>G	c.(193-195)aAg>aGg	p.K65R	EFCAB12_ENST00000326085.3_Missense_Mutation_p.K65R	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		CTGATCCTCCTTGCGAGGCAC	0.557000													15	30					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82875883	82875883	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr5:82875883G>A	ENST00000265077.3	+	14	10530	c.9965G>A	c.(9964-9966)aGa>aAa	p.R3322K	VCAN_ENST00000502527.2_Missense_Mutation_p.R581K|VCAN_ENST00000512590.2_Missense_Mutation_p.R1520K|VCAN_ENST00000342785.4_Missense_Mutation_p.R1568K|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000343200.5_Missense_Mutation_p.R2335K|VCAN-AS1_ENST00000513899.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3322	Sushi.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCCCTGATTAGATACCACTGC	0.438000													44	48					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415004	62415004	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr11:62415004G>A	ENST00000330574.2	-	2	2600	c.2548C>T	c.(2548-2550)Cgc>Tgc	p.R850C		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	850					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						TCGCGGAAGCGCCGGCCAATG	0.672000													30	88					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43833789	43833789	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:43833789T>C	ENST00000389420.3	-	17	2373	c.2374A>G	c.(2374-2376)Aca>Gca	p.T792A	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.T792A	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	792	Spacer.			Missing (in Ref. 2; CAD56159/CAD56160).		proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACAGTTCTTGTTCCTTGCACA	0.313000													6	9					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129906835	129906835	+	Missense_Mutation	SNP	C	C	G	rs144881533		TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:129906835C>G	ENST00000368654.3	-	13	3644	c.3269G>C	c.(3268-3270)aGa>aCa	p.R1090T	MKI67_ENST00000368653.3_Missense_Mutation_p.R730T	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1090	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTAGGCGTTCTTGGCCACTT	0.522000													36	161					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39977976	39977976	+	Silent	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:39977976C>A	ENST00000321562.4	+	9	1574	c.1470C>A	c.(1468-1470)ccC>ccA	p.P490P	FKBP10_ENST00000544340.1_Silent_p.P263P	NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	490					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		ATGGGCTGCCCACAGGCTACC	0.637000													29	87					1.13719e-10	1.23647e-10	1	1	0
SYNJ1	8867	broad.mit.edu	37	21	34011985	34011985	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr21:34011985C>T	ENST00000382499.2	-	30	3809	c.3810G>A	c.(3808-3810)tcG>tcA	p.S1270S	SYNJ1_ENST00000433931.2_Silent_p.S1270S|SYNJ1_ENST00000357345.3_Silent_p.S1215S|SYNJ1_ENST00000382491.3_Silent_p.S1184S|SYNJ1_ENST00000322229.7_Silent_p.S1231S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1231	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						ACCTACCTTTCGACGTTTCTG	0.527000													8	37					0	0	1	0	0
GPR61	83873	broad.mit.edu	37	1	110086714	110086714	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:110086714T>C	ENST00000527748.1	+	2	1753	c.1070T>C	c.(1069-1071)gTc>gCc	p.V357A		NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	357						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		AAGCAGTTTGTCTGCTTCTTC	0.557000													36	47					0	0	1	0	0
TNFRSF14	8764	broad.mit.edu	37	1	2491372	2491372	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:2491372C>T	ENST00000355716.4	+	4	714	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	TNFRSF14_ENST00000409119.1_Missense_Mutation_p.R139C	NM_003820.2	NP_003811.2	Q92956	TNR14_HUMAN	tumor necrosis factor receptor superfamily, member 14	139					immune response|interspecies interaction between organisms|T cell costimulation		tumor necrosis factor receptor activity			kidney(1)	1	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;1.11e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000326)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		CGCCGCGTGCCGCGCTTACGC	0.701000			"""Mis, N, F"""		follicular lymphoma								16	7					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47583530	47583530	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:47583530G>T	ENST00000334194.3	+	12	1445	c.1442G>T	c.(1441-1443)aGg>aTg	p.R481M	CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4Z1_ENST00000471598.1_3'UTR	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	481						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						GACCACTCAAGGCCTCCCCAG	0.453000													15	41					8.60227e-14	9.58139e-14	1	1	0
BMP3	651	broad.mit.edu	37	4	81967536	81967536	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr4:81967536T>C	ENST00000282701.2	+	2	1281	c.961T>C	c.(961-963)Tac>Cac	p.Y321H		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	321					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						GAGAAAGCCTTACAAGACCCT	0.502000													6	41					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88578209	88578209	+	Missense_Mutation	SNP	C	C	T	rs138537025	byFrequency	TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr4:88578209C>T	ENST00000339673.6	+	3	179	c.80C>T	c.(79-81)tCt>tTt	p.S27F	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.S27F	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	27					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AATAATGAATCTGAGGATTCT	0.254000													9	36					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23300139	23300139	+	RNA	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr15:23300139G>C	ENST00000560464.1	-	0	4148																											CGAAGGGTGAGTGGACTCCAC	0.602000													7	26					0	0	1	0	0
HCG17	414778	broad.mit.edu	37	6	30227442	30227442	+	RNA	SNP	T	T	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr6:30227442T>G	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							CTGCTGCTCTTGGGGGCCCTG	0.706000													3	33					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94043231	94043231	+	Silent	SNP	T	T	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr5:94043231T>A	ENST00000515393.1	-	23	2969	c.2970A>T	c.(2968-2970)ccA>ccT	p.P990P	MCTP1_ENST00000312216.8_Silent_p.P769P|MCTP1_ENST00000514040.1_Intron|ANKRD32_ENST00000493934.1_Intron|MCTP1_ENST00000505078.1_Silent_p.P506P|MCTP1_ENST00000429576.2_Silent_p.P683P	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	990					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTCTTTTATATGGGCTATGAG	0.458000													31	42					0	0	1	0	0
CXCL1	2919	broad.mit.edu	37	4	74735639	74735639	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr4:74735639G>A	ENST00000395761.3	+	3	308	c.241G>A	c.(241-243)Ggg>Agg	p.G81R	CXCL1_ENST00000509101.1_3'UTR	NM_001511.3	NP_001502.1	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	81					actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity			lung(2)	2	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			ACTCAAGAATGGGCGGAAAGC	0.567000													30	63					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245684	46245684	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:46245684G>T	ENST00000334344.6	+	15	3950	c.3778G>T	c.(3778-3780)Gaa>Taa	p.E1260*	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000444670.1_Nonsense_Mutation_p.E870*|ARID2_ENST00000422737.1_Nonsense_Mutation_p.E1111*	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1260					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACATGTTCATGAACGTAAAAT	0.433000			"""N, S, F"""		hepatocellular carcinoma								22	54					1.55795e-14	1.7495e-14	1	1	0
DNM1	1759	broad.mit.edu	37	9	130982551	130982551	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr9:130982551C>T	ENST00000341179.7	+	6	872	c.780C>T	c.(778-780)ctC>ctT	p.L260L	DNM1_ENST00000475805.1_Silent_p.L260L|DNM1_ENST00000486160.1_Silent_p.L260L|DNM1_ENST00000393594.3_Silent_p.L260L|DNM1_ENST00000372923.3_Silent_p.L260L	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	260					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						AGTTCTTCCTCTCCCATCCAT	0.567000													88	101					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768568	88768568	+	RNA	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:88768568G>C	ENST00000444431.1	+	0	3168				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GCCATCCCTAGCCACATCGGC	0.463000													58	103					0	0	1	0	0
LPGAT1	9926	broad.mit.edu	37	1	211966515	211966515	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:211966515C>T	ENST00000366997.4	-	3	482	c.256G>A	c.(256-258)Gat>Aat	p.D86N	LPGAT1_ENST00000366996.1_Missense_Mutation_p.D86N	NM_014873.2	NP_055688.1	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	86					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		GCTTTAATATCTTCTCCCCAT	0.348000													18	163					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74288000	74288000	+	Silent	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:74288000G>T	ENST00000262765.5	-	4	2489	c.2310C>A	c.(2308-2310)gcC>gcA	p.A770A		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	770							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CAAGAGGATAGGCACCAGGTT	0.517000													5	167					4.096e-09	4.41852e-09	1	1	0
IGHV3-66	28412	broad.mit.edu	37	14	107131463	107131463	+	RNA	SNP	A	A	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr14:107131463A>C	ENST00000390632.2	-	0	97																											AGGAAAACCCAGCTCAGCCCA	0.488000													56	144					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73834251	73834251	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr6:73834251C>T	ENST00000370392.1	+	9	1347	c.1263C>T	c.(1261-1263)ctC>ctT	p.L421L	KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000355194.4_Intron|KCNQ5_ENST00000355635.3_Intron|KCNQ5_ENST00000402622.2_Intron|KCNQ5_ENST00000342056.2_Intron|KCNQ5_ENST00000370398.1_Intron|KCNQ5_ENST00000403813.2_Intron			Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	0					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TGATTTCTCTCTTGCTACATG	0.363000													16	60					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12397432	12397432	+	Missense_Mutation	SNP	G	G	T	rs145354281	byFrequency	TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:12397432G>T	ENST00000261349.4	-	2	289	c.213C>A	c.(211-213)agC>agA	p.S71R	LRP6_ENST00000543091.1_Missense_Mutation_p.S71R	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	71	Beta-propeller 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TGGCTTCTTCGCTGACATCAC	0.453000													4	61					0.150653	0.151761	1	1	0
AOC1	26	broad.mit.edu	37	7	150557702	150557702	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:150557702A>T	ENST00000493429.1	+	6	2554	c.1970A>T	c.(1969-1971)aAc>aTc	p.N657I	AOC1_ENST00000467291.1_Missense_Mutation_p.N657I|AOC1_ENST00000360937.4_Missense_Mutation_p.N657I|AOC1_ENST00000416793.2_Missense_Mutation_p.N676I|AOC1_ENST00000480582.1_3'UTR					amine oxidase, copper containing 1																		CTTCACAACAACGAGAACATT	0.597000													31	84					0	0	1	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812859	31812859	+	Nonsense_Mutation	SNP	C	C	T	rs145057150		TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr21:31812859C>T	ENST00000334067.3	+	1	263	c.214C>T	c.(214-216)Cag>Tag	p.Q72*		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	72						intermediate filament				kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						CAGATCCTATCAGACATCCTG	0.512000													47	85					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89937127	89937127	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:89937127G>A	ENST00000389297.4	+	21	2760	c.2509G>A	c.(2509-2511)Gaa>Aaa	p.E837K	C7orf63_ENST00000316089.8_Missense_Mutation_p.E791K|C7orf63_ENST00000497910.1_Missense_Mutation_p.E819K	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	837							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						TAAATCATGGGAAGATTTCTT	0.328000													15	35					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14277196	14277196	+	RNA	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr11:14277196C>T	ENST00000310358.7	+	0	1631							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CTTGCAGTCACCCAACAAACC	0.473000													32	115					0	0	1	0	0
COPRS	55352	broad.mit.edu	37	17	30179888	30179888	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:30179888C>A	ENST00000378634.2	-	3	545	c.292G>T	c.(292-294)Gat>Tat	p.D98Y	COPRS_ENST00000302362.6_Missense_Mutation_p.D110Y					coordinator of PRMT5, differentiation stimulator																		TTAAAAAGATCGCCAGGCTGT	0.517000													64	194					2.18419e-29	2.53589e-29	1	1	0
DBH	1621	broad.mit.edu	37	9	136508639	136508639	+	Silent	SNP	C	C	T	rs78200745		TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr9:136508639C>T	ENST00000393056.2	+	4	861	c.849C>T	c.(847-849)tgC>tgT	p.C283C		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	283					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GCGGGCCCTGCGACTCCAAGA	0.662000													28	114					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414210	61414210	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:61414210G>A	ENST00000395348.3	-	5	1210	c.574C>T	c.(574-576)Caa>Taa	p.Q192*	SLC16A9_ENST00000395347.1_Nonsense_Mutation_p.Q192*	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	192					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						TCAGAAGATTGGAGGGGTCTC	0.398000													22	92					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47886546	47886546	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:47886546C>T	ENST00000503935.2	+	6	1297	c.261C>T	c.(259-261)aaC>aaT	p.N87N	KAT7_ENST00000435742.2_Intron|KAT7_ENST00000424009.2_Intron|KAT7_ENST00000510819.1_Intron|KAT7_ENST00000509773.1_Intron|KAT7_ENST00000454930.2_Silent_p.N104N|KAT7_ENST00000259021.4_Silent_p.N243N			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	243					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										AAGATGACAACAACAGGCATG	0.478000													13	34					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35604999	35604999	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:35604999C>T	ENST00000353139.5	-	18	2726	c.2245G>A	c.(2245-2247)Ggt>Agt	p.G749S	ACACA_ENST00000394406.2_Missense_Mutation_p.G712S|ACACA_ENST00000360679.3_Missense_Mutation_p.G654S|ACACA_ENST00000335166.5_Missense_Mutation_p.G634S	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	712					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	AGCAGTCCACCGTCACTCAGC	0.473000													9	59					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17716877	17716877	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr19:17716877C>T	ENST00000428389.2	-	45	5361	c.5362G>A	c.(5362-5364)Gcg>Acg	p.A1788T	UNC13A_ENST00000551649.1_Missense_Mutation_p.A1719T|UNC13A_ENST00000552293.1_Missense_Mutation_p.A1694T|UNC13A_ENST00000252773.7_Missense_Mutation_p.A1700T|UNC13A_ENST00000550896.1_Missense_Mutation_p.A1673T|UNC13A_ENST00000519716.2_Missense_Mutation_p.A1700T			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1700					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GGCGCAGGCGCGGCACCGCCC	0.736000													9	6					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554304	85554304	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr2:85554304G>A	ENST00000377386.3	-	2	1013	c.551C>T	c.(550-552)gCg>gTg	p.A184V	TGOLN2_ENST00000409232.3_Missense_Mutation_p.A184V|TGOLN2_ENST00000409015.1_Missense_Mutation_p.A184V|TGOLN2_ENST00000398263.2_Missense_Mutation_p.A184V|TGOLN2_ENST00000444342.2_Missense_Mutation_p.A184V|TGOLN2_ENST00000282120.2_Missense_Mutation_p.A86V			O43493	TGON2_HUMAN	trans-golgi network protein 2	184	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										CTGGCCGTCCGCACCCGACTT	0.587000													7	658					0	0	1	0	0
PQLC2	54896	broad.mit.edu	37	1	19652808	19652808	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:19652808C>A	ENST00000375153.3	+	5	1092	c.452C>A	c.(451-453)gCt>gAt	p.A151D	PQLC2_ENST00000375155.3_Missense_Mutation_p.A151D|PQLC2_ENST00000400548.2_Missense_Mutation_p.A86D	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	151						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCTGAGTGCTGCTGGGCCC	0.677000													3	34					1	1	1	1	0
CYP2C8	1558	broad.mit.edu	37	10	96796914	96796914	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:96796914A>G	ENST00000371270.3	-	9	1538	c.1444T>C	c.(1444-1446)Tca>Cca	p.S482P	CYP2C8_ENST00000535898.1_Missense_Mutation_p.S380P	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	482					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	ATCTGGTATGAGGGTGGCAGA	0.418000													3	47					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1016697	1016697	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr11:1016697G>A	ENST00000421673.2	-	31	6154	c.6104C>T	c.(6103-6105)tCt>tTt	p.S2035F		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	2035	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GATGGAGGCAGAAGTGGCCAT	0.567000													72	516					0	0	1	0	0
CYB5RL	606495	broad.mit.edu	37	1	54640384	54640384	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:54640384C>A	ENST00000419823.2	-	7	1080	c.856G>T	c.(856-858)Gca>Tca	p.A286S	CYB5RL_ENST00000401046.3_Missense_Mutation_p.A138S|CYB5RL_ENST00000542737.1_Missense_Mutation_p.A286S|CYB5RL_ENST00000537208.1_Missense_Mutation_p.A218S|RP11-446E24.4_ENST00000311841.7_Intron|CYB5RL_ENST00000534324.1_Missense_Mutation_p.A286S|CYB5RL_ENST00000287899.8_Missense_Mutation_p.A218S	NM_001031672.2	NP_001026842.2	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	286							cytochrome-b5 reductase activity	p.A286T(1)		endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|urinary_tract(1)	8						CAGACCAGTGCGAATGGCTTT	0.552000													9	26					3.86212e-05	4.00841e-05	1	1	0
ABCC12	94160	broad.mit.edu	37	16	48174625	48174625	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr16:48174625C>T	ENST00000311303.3	-	4	975	c.630G>A	c.(628-630)aaG>aaA	p.K210K	ABCC12_ENST00000448542.1_Silent_p.K210K|ABCC12_ENST00000416054.1_Silent_p.K210K	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	210	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GGGTCAATGTCTTGAAGGACA	0.517000													72	167					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296403	145296403	+	Silent	SNP	C	C	T	rs4996269	by1000genomes	TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:145296403C>T	ENST00000342960.5	+	3	360	c.325C>T	c.(325-327)Cta>Tta	p.L109L	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	109										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCTGACCCAGCTAAGGGAGAA	0.517000													5	304					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72332273	72332273	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr4:72332273G>T	ENST00000340595.3	+	10	1674	c.1478G>T	c.(1477-1479)aGg>aTg	p.R493M	SLC4A4_ENST00000264485.5_Missense_Mutation_p.R537M|SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000512686.1_Missense_Mutation_p.R493M|SLC4A4_ENST00000351898.6_Missense_Mutation_p.R537M|SLC4A4_ENST00000425175.1_Missense_Mutation_p.R537M	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	537						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GTTTTTGAGAGGCTTCTATTT	0.393000													23	51					2.70639e-06	2.87423e-06	1	1	0
AK5	26289	broad.mit.edu	37	1	77752791	77752791	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:77752791C>T	ENST00000344720.5	+	2	1174	c.148C>T	c.(148-150)Cgg>Tgg	p.R50W	AK5_ENST00000317704.4_3'UTR|AK5_ENST00000354567.2_Missense_Mutation_p.R76W	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	76					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						AGGACAGTCACGGAGATCCTT	0.368000													18	50					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129171430	129171430	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chrX:129171430C>T	ENST00000540052.1	+	8	4438	c.4394C>T	c.(4393-4395)tCc>tTc	p.S1465F	BCORL1_ENST00000303743.5_Missense_Mutation_p.S1539F|BCORL1_ENST00000218147.7_Missense_Mutation_p.S1465F|BCORL1_ENST00000359304.2_Missense_Mutation_p.S1335F	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1465					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GAGGCTTGTTCCCGGGGCTGG	0.592000													35	31					0	0	1	0	0
SLC25A17	10478	broad.mit.edu	37	22	41169986	41169986	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr22:41169986A>G	ENST00000402844.3	-	4	1465	c.485T>C	c.(484-486)tTg>tCg	p.L162S	SLC25A17_ENST00000542412.1_Missense_Mutation_p.L171S|SLC25A17_ENST00000435456.2_Missense_Mutation_p.L244S|SLC25A17_ENST00000544408.1_Missense_Mutation_p.L207S|SLC25A17_ENST00000491545.1_5'UTR			O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	244					fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding			central_nervous_system(1)|large_intestine(4)|lung(2)|skin(1)	8						AAGACTTCCCAATGTTCTGTT	0.413000													11	46					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308937	248308937	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:248308937C>T	ENST00000366476.1	+	1	488	c.488C>T	c.(487-489)aCa>aTa	p.T163I		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GCTGTAGCGACATTTTCCTTC	0.443000													84	223					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39974425	39974425	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:39974425G>A	ENST00000321562.4	+	3	580	c.476G>A	c.(475-477)aGc>aAc	p.S159N		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	159					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GTGCAGGTGAGCACATTGCTG	0.622000													8	40					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81732999	81732999	+	Silent	SNP	A	A	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:81732999A>G	ENST00000550584.2	-	20	2803	c.2508T>C	c.(2506-2508)cgT>cgC	p.R836R	PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Silent_p.R818R|PPFIA2_ENST00000443686.3_Silent_p.R737R|PPFIA2_ENST00000407050.4_Silent_p.R762R|PPFIA2_ENST00000541017.1_Silent_p.R53R|PPFIA2_ENST00000541570.2_Silent_p.R403R|PPFIA2_ENST00000549396.1_Silent_p.R836R|PPFIA2_ENST00000548586.1_Silent_p.R836R|PPFIA2_ENST00000552948.1_Silent_p.R836R|PPFIA2_ENST00000333447.7_Silent_p.R818R|PPFIA2_ENST00000550359.2_Silent_p.R683R	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	762										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TACCAAACAAACGTCCTATTG	0.458000													30	99					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	68					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6704223	6704223	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:6704223C>T	ENST00000338694.2	-	7	1021	c.892G>A	c.(892-894)Gct>Act	p.A298T	TEKT1_ENST00000535086.1_Missense_Mutation_p.A152T	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	298					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				TTTTCAAGAGCTGTAATATTT	0.512000													16	109					0	0	1	0	0
DLX5	1749	broad.mit.edu	37	7	96651526	96651526	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:96651526C>T	ENST00000222598.4	-	2	984	c.511G>A	c.(511-513)Gcc>Acc	p.A171T	DLX5_ENST00000493764.1_5'UTR|DLX5_ENST00000486603.2_Missense_Mutation_p.A171T	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	171					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					AGCGAGGCGGCCAGCTCGGCG	0.567000													26	98					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180772700	180772700	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:180772700G>A	ENST00000367590.4	+	4	598	c.400G>A	c.(400-402)Gcc>Acc	p.A134T	XPR1_ENST00000367589.3_Missense_Mutation_p.A134T	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	134	SPX.					integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						CCTTAAACTGGCCTTCAGTGA	0.423000													28	83					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21781651	21781651	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:21781651C>T	ENST00000328843.6	+	50	8073	c.8042C>T	c.(8041-8043)tCa>tTa	p.S2681L	DNAH11_ENST00000409508.3_Missense_Mutation_p.S2674L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2681	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTTGCTCCATCAATTCTCAGG	0.408000									Kartagener syndrome				24	44					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92474060	92474060	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr14:92474060T>C	ENST00000267622.4	-	10	1824	c.1451A>G	c.(1450-1452)aAt>aGt	p.N484S		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	484					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		AATACTCTGATTGAGTTCTTG	0.328000			T	PDGFRB	AML								23	44					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138657566	138657566	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr6:138657566C>T	ENST00000251691.4	+	34	6643	c.6477C>T	c.(6475-6477)cgC>cgT	p.R2159R		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	2159					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TCAGAGTTCGCCAGGCTGTGA	0.572000													54	68					0	0	1	0	0
ANXA1	301	broad.mit.edu	37	9	75775728	75775728	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr9:75775728A>G	ENST00000376911.1	+	5	1276	c.394A>G	c.(394-396)Act>Gct	p.T132A	ANXA1_ENST00000257497.6_Missense_Mutation_p.T132A			P04083	ANXA1_HUMAN	annexin A1	132					alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(5)	8		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	GGGCCTTGGAACTGATGAAGA	0.348000													23	110					0	0	1	0	0
CCDC102A	92922	broad.mit.edu	37	16	57559864	57559864	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr16:57559864G>C	ENST00000258214.2	-	3	1007	c.761C>G	c.(760-762)gCc>gGc	p.A254G		NM_033212.3	NP_149989.2	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	254										endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8						TAGCCGCAGGGCGGTCAACTT	0.721000													9	27					0	0	1	0	0
HOXB5	3215	broad.mit.edu	37	17	46670537	46670537	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:46670537C>T	ENST00000239151.5	-	1	786	c.508G>A	c.(508-510)Gag>Aag	p.E170K	HOXB3_ENST00000552000.2_Intron|HOXB-AS3_ENST00000465846.2_RNA|HOXB-AS3_ENST00000476204.1_RNA|HOXB-AS3_ENST00000429755.4_RNA|HOXB-AS3_ENST00000480872.1_RNA|HOXB-AS3_ENST00000467155.2_RNA|HOXB-AS3_ENST00000474040.1_RNA|HOXB-AS3_ENST00000492897.3_RNA|HOXB-AS3_ENST00000487849.3_RNA	NM_002147.3	NP_002138.1	P09067	HXB5_HUMAN	homeobox B5	170						nucleus	sequence-specific DNA binding			large_intestine(1)|lung(2)	3						GTCTGCCCCTCGGGCGCGGCT	0.607000													23	71					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33698459	33698459	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr19:33698459A>T	ENST00000253193.7	+	7	2493	c.2291A>T	c.(2290-2292)gAt>gTt	p.D764V		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	764					receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					GCCAGCGATGATGAGGCCCTG	0.657000													9	26					0	0	1	0	0
E2F3	1871	broad.mit.edu	37	6	20490660	20490660	+	Nonstop_Mutation	SNP	G	G	C			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr6:20490660G>C	ENST00000346618.3	+	7	1463	c.1397G>C	c.(1396-1398)tGa>tCa	p.*466S	E2F3_ENST00000535432.1_Nonstop_Mutation_p.*335S	NM_001949.4	NP_001940.1	O00716	E2F3_HUMAN	E2F transcription factor 3	0					G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)	7	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			ATGTGTAGTTGATTATGCTTC	0.458000													48	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587386	179587386	+	Splice_Site	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr2:179587386C>T	ENST00000589042.1	-	76	22464	c.22240_splice	c.e76+1	p.E7414_splice	TTN_ENST00000591111.1_Splice_Site_p.E7097_splice|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Splice_Site_p.E6170_splice|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7097	Ig-like 56.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATCATCACCTTGAATTCTG	0.303000													9	17					0	0	1	0	0
RGPD1	400966	broad.mit.edu	37	2	87141032	87141032	+	Silent	SNP	G	G	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr2:87141032G>T	ENST00000398193.3	+	1	98	c.60G>T	c.(58-60)ccG>ccT	p.P20P	RGPD1_ENST00000409776.2_Intron			Q68DN6	RGPD1_HUMAN	RANBP2-like and GRIP domain containing 1	0					intracellular transport		binding			breast(1)|endometrium(1)|lung(1)	3						GCTCCGCCCCGTCGCCTGGAA	0.736000													4	7					0.014758	0.0149766	1	1	0
OR6T1	219874	broad.mit.edu	37	11	123813778	123813778	+	Silent	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr11:123813778G>A	ENST00000321252.2	-	1	802	c.768C>T	c.(766-768)atC>atT	p.I256I		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGTAGAGAAAGATGGAACTGC	0.517000													41	86					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130776	45130776	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr20:45130776C>G	ENST00000457685.2	-	6	2411	c.1088G>C	c.(1087-1089)gGg>gCg	p.G363A	ZNF334_ENST00000593880.1_Missense_Mutation_p.G424A|ZNF334_ENST00000347606.4_Missense_Mutation_p.G401A			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GGGTTTTTCCCCTGTGTGAAT	0.433000													14	110					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78582051	78582051	+	Silent	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr12:78582051G>A	ENST00000397909.2	+	32	5987	c.5814G>A	c.(5812-5814)ttG>ttA	p.L1938L	NAV3_ENST00000536525.2_Silent_p.L1916L|NAV3_ENST00000266692.7_Silent_p.L1739L|NAV3_ENST00000552300.1_3'UTR|NAV3_ENST00000228327.6_Silent_p.L1916L			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1938						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.L1916F(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGGCATATTTGATAGGATCCA	0.323000										HNSCC(70;0.22)			19	56					0	0	1	0	0
SLC35A5	55032	broad.mit.edu	37	3	112301521	112301521	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr3:112301521G>A	ENST00000492406.1	+	7	1496	c.1213G>A	c.(1213-1215)Gga>Aga	p.G405R	SLC35A5_ENST00000460713.1_3'UTR	NM_017945.2	NP_060415.1	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	405						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|skin(1)	11						CTTTTAGGATGGAGAAGAACT	0.363000													16	38					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	47					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992568	42992568	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:42992568G>A	ENST00000253408.5	-	1	352	c.287C>T	c.(286-288)gCg>gTg	p.A96V	GFAP_ENST00000435360.2_Missense_Mutation_p.A96V|GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000586793.1_Missense_Mutation_p.A96V	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	96	Coil 1A.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				AGCAGCCAGCGCCTTGTTTTG	0.612000													11	51					0	0	1	0	0
TYSND1	219743	broad.mit.edu	37	10	71902510	71902510	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr10:71902510G>A	ENST00000287078.6	-	3	1396	c.1397C>T	c.(1396-1398)aCg>aTg	p.T466M	TYSND1_ENST00000494143.1_5'UTR|TYSND1_ENST00000335494.5_Intron	NM_173555.2	NP_775826.2	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1	466	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(3)|prostate(1)	9						CATTACGGGCGTGCCATTCAC	0.612000													4	37					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6530577	6530577	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr1:6530577delC	ENST00000377748.1	-	16	2397	c.1900delG	c.(1900-1902)aafs	p.E634fs	PLEKHG5_ENST00000535355.1_Frame_Shift_Del_p.E626fs|PLEKHG5_ENST00000537245.1_Frame_Shift_Del_p.E636fs|PLEKHG5_ENST00000340850.5_Frame_Shift_Del_p.E557fs|PLEKHG5_ENST00000544978.1_Frame_Shift_Del_p.E557fs|PLEKHG5_ENST00000377732.1_Frame_Shift_Del_p.E594fs|PLEKHG5_ENST00000377740.3_Frame_Shift_Del_p.E634fs|PLEKHG5_ENST00000377737.2_Frame_Shift_Del_p.E557fs|PLEKHG5_ENST00000377728.3_Frame_Shift_Del_p.E557fs|PLEKHG5_ENST00000400913.1_Frame_Shift_Del_p.E557fs|PLEKHG5_ENST00000377725.1_Frame_Shift_Del_p.E557fs|PLEKHG5_ENST00000400915.3_Frame_Shift_Del_p.E613fs	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	613					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		TTGTCCACTTCGTCGCTGCTG	0.687													32	72	---	---	---	---					
CCT6P1	643253	broad.mit.edu	37	7	65226568	65226569	+	RNA	INS	-	-	T			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:65226568_65226569insT	ENST00000442266.1	+	0	1167																											tgcccggccCCttttttttttt	0.411													3	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89748927	89748928	+	RNA	INS	-	-	C	rs138239781	by1000genomes	TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr7:89748927_89748928insC	ENST00000478318.2	-	0	424				DPY19L2P4_ENST00000497063.1_RNA|RP5-1121E10.2_ENST00000471553.1_lincRNA																							GGTGCGGGCCTCCCCCTTCCCC	0.639													2	4	---	---	---	---					
CD276	80381	broad.mit.edu	37	15	74003500	74003500	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr15:74003500delA	ENST00000318443.5	+	9	1873	c.1571delA	c.(1570-1572)gcfs	p.D524fs	CD276_ENST00000318424.5_Frame_Shift_Del_p.D306fs|CD276_ENST00000564751.1_Frame_Shift_Del_p.D306fs|CD276_ENST00000561213.1_Frame_Shift_Del_p.D524fs|CD276_ENST00000537340.2_Frame_Shift_Del_p.D378fs	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	524					cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						AAACACTCTGACAGCAAAGAA	0.542													8	96	---	---	---	---					
SUZ12P1	440423	broad.mit.edu	37	17	29086616	29086616	+	RNA	DEL	A	A	-			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:29086616delA	ENST00000582557.1	+	0	1064																											TTGTGAATGTAAAAAAAAAGT	0.299													2	4	---	---	---	---					
EVPL	2125	broad.mit.edu	37	17	74003394	74003407	+	Frame_Shift_Del	DEL	GATCATCCCGGAGA	GATCATCCCGGAGA	-			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr17:74003394_74003407delGATCATCCCGGAGA	ENST00000301607.3	-	22	6132_6145	c.5879_5892delTCTCCGGGATGATC	c.(5878-5892)cfs	p.LSGMI1960fs	EVPL_ENST00000586740.1_Frame_Shift_Del_p.LSGMI1982fs	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1960	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCTCTTCACTGATCATCCCGGAGAGGAGGGCCTG	0.640													30	86	---	---	---	---					
CACNA1A	773	broad.mit.edu	37	19	13441114	13441114	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A6EQ-01A-11D-A31L-08	TCGA-D6-A6EQ-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60d93b0a-f054-48cc-b0ae-03e05a209007	0c2dab79-6367-4c3e-9e98-1ab522d61c7b	g.chr19:13441114delG	ENST00000360228.5	-	10	1288	c.1289delC	c.(1288-1290)aafs	p.T430fs	CACNA1A_ENST00000573710.2_Frame_Shift_Del_p.T431fs	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	431					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GAGCAAATCTGTCTTGCTTTT	0.478													2	4	---	---	---	---