Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MCMDC2	157777	broad.mit.edu	37	8	67786675	67786675	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:67786675C>T	ENST00000422365.2	+	3	380	c.209C>T	c.(208-210)gCt>gTt	p.A70V	MCMDC2_ENST00000492775.1_Missense_Mutation_p.A70V|MCMDC2_ENST00000313616.5_Missense_Mutation_p.A70V|MCMDC2_ENST00000469823.1_3'UTR|MCMDC2_ENST00000396592.3_Missense_Mutation_p.A70V|MCMDC2_ENST00000541540.1_Intron	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	70					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						TTAAAAGCTGCTGAAGTCTTT	0.308000													4	42					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133539877	133539877	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:133539877C>A	ENST00000409261.1	-	14	4880	c.4507G>T	c.(4507-4509)Ggg>Tgg	p.G1503W	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.G1503W	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1503							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AAAGAAGGCCCAGGCTTCTGC	0.458000													23	37					3.5997e-14	4.45488e-14	1	1	0
AQR	9716	broad.mit.edu	37	15	35196564	35196564	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:35196564C>G	ENST00000156471.5	-	19	2199	c.1974G>C	c.(1972-1974)agG>agC	p.R658S		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	658						catalytic step 2 spliceosome	RNA binding	p.R658R(1)		breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TTGGTTTTCTCCTCATTATTA	0.289000													7	32					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126715728	126715728	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:126715728C>T	ENST00000309035.6	-	1	731	c.601G>A	c.(601-603)Gag>Aag	p.E201K	CTBP2_ENST00000494626.2_Intron|CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000337195.5_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GCAGGCACCTCCGCCCCATAC	0.647000													10	63					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73831565	73831565	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:73831565C>T	ENST00000207549.4	-	20	2152	c.1773G>A	c.(1771-1773)ccG>ccA	p.P591P	UNC13D_ENST00000412096.2_Silent_p.P591P	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	591	MHD1.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGGGATGGCCGGCTGGAACC	0.692000									Familial Hemophagocytic Lymphohistiocytosis				4	14					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183646567	183646567	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:183646567C>T	ENST00000334444.6	-	27	4141	c.3901G>A	c.(3901-3903)Gat>Aat	p.D1301N	ABCC5_ENST00000265586.6_Missense_Mutation_p.D1258N	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1301	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCCAGGGCATCCCAAATCTGG	0.517000													15	61					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135738623	135738623	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:135738623T>C	ENST00000375845.3	-	9	3718	c.3688A>G	c.(3688-3690)Act>Gct	p.T1230A	MAP3K19_ENST00000392915.1_3'UTR|MAP3K19_ENST00000315513.3_Missense_Mutation_p.T91A|MAP3K19_ENST00000392917.3_Missense_Mutation_p.T362A|MAP3K19_ENST00000358371.4_Missense_Mutation_p.T1117A|MAP3K19_ENST00000392918.3_Missense_Mutation_p.T364A|MAP3K19_ENST00000375844.3_Missense_Mutation_p.T412A	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		CAATATGGAGTCCCATGCATG	0.478000													21	31					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112528290	112528290	+	Silent	SNP	G	G	T	rs144933976		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:112528290G>T	ENST00000230538.7	-	4	751	c.354C>A	c.(352-354)atC>atA	p.I118I	LAMA4_ENST00000424408.2_Silent_p.I118I|LAMA4_ENST00000522006.1_Silent_p.I118I|LAMA4_ENST00000524032.1_5'UTR|LAMA4_ENST00000389463.4_Silent_p.I118I	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	118	Laminin EGF-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TGGAATCTCCGATATAACCAT	0.502000													16	50					3.41278e-10	4.04478e-10	1	1	0
RTEL1	51750	broad.mit.edu	37	20	62326924	62326924	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr20:62326924G>C	ENST00000318100.4	+	34	4570	c.3743G>C	c.(3742-3744)gGg>gCg	p.G1248A	RTEL1_ENST00000360203.5_Missense_Mutation_p.G1248A|RTEL1_ENST00000508582.2_Intron|RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.G1248A|RTEL1_ENST00000370003.1_Missense_Mutation_p.G493A|RTEL1_ENST00000370018.3_Intron			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	0					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CAGGGCTGTGGGGCAGAGGAC	0.672000													9	46					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118476009	118476009	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:118476009A>G	ENST00000349139.4	+	2	114	c.67A>G	c.(67-69)Aaa>Gaa	p.K23E	WDR3_ENST00000369441.3_Missense_Mutation_p.K23E|WDR3_ENST00000471680.1_3'UTR	NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	23						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		CGGCAGCCAAAAAGGTAATAT	0.468000													20	61					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328722	3328722	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:3328722C>T	ENST00000378398.3	+	10	2046	c.1964C>T	c.(1963-1965)gCg>gTg	p.A655V	PRDM16_ENST00000514189.1_Missense_Mutation_p.A655V|PRDM16_ENST00000511072.1_Missense_Mutation_p.A655V|PRDM16_ENST00000442529.2_Missense_Mutation_p.A654V|PRDM16_ENST00000441472.2_Missense_Mutation_p.A654V|PRDM16_ENST00000378391.2_Missense_Mutation_p.A654V|PRDM16_ENST00000270722.5_Missense_Mutation_p.A654V|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	654					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGCGGCTTGGCGCCCCCGGGG	0.682000			T	EVI1	"""MDS, AML"""								27	65					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883495	228883495	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:228883495G>A	ENST00000392056.3	-	7	2121	c.2075C>T	c.(2074-2076)cCc>cTc	p.P692L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P692L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	692						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GTTGTCATTGGGGTCGATTAT	0.393000													68	114					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122755657	122755657	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:122755657C>T	ENST00000194130.2	-	15	1742	c.1703G>A	c.(1702-1704)gGc>gAc	p.G568D	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	568						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	AGTACATATGCCAAGCATAAC	0.433000													32	43					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852132	63852132	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:63852132A>T	ENST00000279873.7	+	10	3320	c.2910A>T	c.(2908-2910)gaA>gaT	p.E970D	ARID5B_ENST00000309334.5_Missense_Mutation_p.E727D	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	970					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					AATACCCTGAATCGCTTTCAA	0.522000													18	98					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68207277	68207277	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:68207277G>T	ENST00000294304.7	+	21	4487	c.4381G>T	c.(4381-4383)Gtg>Ttg	p.V1461L		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1461					adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GATGAGCTCCGTGAGCCTGAT	0.672000													7	12					6.5536e-12	7.80854e-12	1	1	0
SLC22A15	55356	broad.mit.edu	37	1	116605438	116605438	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:116605438G>A	ENST00000369503.4	+	9	1357	c.1227G>A	c.(1225-1227)ctG>ctA	p.L409L		NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	409					ion transport	integral to membrane	transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGGGGAAGCTGACCATCAGTG	0.483000													57	180					0	0	1	0	0
XAF1	54739	broad.mit.edu	37	17	6674069	6674069	+	Silent	SNP	G	G	A	rs143903776		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:6674069G>A	ENST00000361842.3	+	6	854	c.615G>A	c.(613-615)acG>acA	p.T205T	XAF1_ENST00000441631.1_Silent_p.T205T|XAF1_ENST00000346752.4_Silent_p.T186T	NM_017523.3	NP_059993.2	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1	205					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding			large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	6						AAACTTCCACGATGGAGAAAG	0.378000													16	59					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181979	128181979	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:128181979T>A	ENST00000469083.1	-	2	2667	c.110A>T	c.(109-111)gAc>gTc	p.D37V	DNAJB8_ENST00000319153.3_Missense_Mutation_p.D37V			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	37	J.				protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CTCCTTATTGTCAGGGTTCTT	0.572000													35	135					0	0	1	0	0
MS4A4A	51338	broad.mit.edu	37	11	60068506	60068506	+	Silent	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:60068506A>T	ENST00000355131.3	+	5	529	c.306A>T	c.(304-306)gcA>gcT	p.A102A	MS4A4A_ENST00000395016.3_Silent_p.A102A|MS4A4A_ENST00000532114.1_Silent_p.A121A|MS4A4A_ENST00000337908.4_Silent_p.A121A	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	121						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						CAATTGCAGCAGGAATTAGAA	0.308000													3	21					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400630	40400630	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:40400630T>C	ENST00000338305.6	-	2	765	c.223A>G	c.(223-225)Atg>Gtg	p.M75V		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	75						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCCCCGTCATGTTGGCAAAG	0.602000													15	60					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43030739	43030739	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:43030739G>T	ENST00000394056.2	+	4	838	c.343G>T	c.(343-345)Gag>Tag	p.E115*	KLC4_ENST00000259708.3_Nonsense_Mutation_p.E133*|KLC4_ENST00000479388.1_Nonsense_Mutation_p.E115*|KLC4_ENST00000458460.2_Nonsense_Mutation_p.E115*|KLC4_ENST00000347162.5_Nonsense_Mutation_p.E115*|KLC4_ENST00000394058.1_Nonsense_Mutation_p.E115*|KLC4_ENST00000453940.2_Intron			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	115						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			GCTATGCCAGGAGAACCAGTG	0.627000													15	68					5.3912e-06	6.00811e-06	1	1	0
F8	2157	broad.mit.edu	37	X	154158240	154158240	+	Silent	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:154158240A>G	ENST00000360256.4	-	14	4025	c.3825T>C	c.(3823-3825)gaT>gaC	p.D1275D		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1275	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TATTTGTTGAATCATTTAATG	0.373000													9	21					0	0	1	0	0
CHST10	9486	broad.mit.edu	37	2	101009787	101009787	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:101009787C>G	ENST00000264249.3	-	7	1376	c.991G>C	c.(991-993)Gac>Cac	p.D331H	CHST10_ENST00000542617.1_Missense_Mutation_p.D379H|CHST10_ENST00000409701.1_Missense_Mutation_p.D331H	NM_004854.4	NP_004845.1	O43529	CHSTA_HUMAN	carbohydrate sulfotransferase 10	331					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						CGTCGGATGTCTCGTTTGCTG	0.483000													11	70					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541268	31541268	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:31541268C>G	ENST00000454783.1	+	4	674	c.416C>G	c.(415-417)tCc>tGc	p.S139C	LTA_ENST00000418386.2_Missense_Mutation_p.S139C	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	139					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CAGCTCTTCTCCTCCCAGTAC	0.597000													26	130					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180055919	180055919	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:180055919C>T	ENST00000261937.6	-	8	1144	c.1066G>A	c.(1066-1068)Gtg>Atg	p.V356M	FLT4_ENST00000502649.1_Missense_Mutation_p.V356M|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.V356M	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	356	Ig-like C2-type 4.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GCCAGCTTCACGGGCAGCTTC	0.627000													7	45					0	0	1	0	0
CCDC96	257236	broad.mit.edu	37	4	7043919	7043919	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:7043919C>T	ENST00000310085.4	-	1	809	c.747G>A	c.(745-747)ctG>ctA	p.L249L	RP11-367J11.2_ENST00000500031.1_RNA	NM_153376.2	NP_699207.1	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	249										endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|urinary_tract(1)	11						TCTTGTGCTGCAGGTATAGGT	0.652000													32	107					0	0	1	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895620	42895620	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:42895620G>C	ENST00000399770.2	+	1	337	c.337G>C	c.(337-339)Gtg>Ctg	p.V113L		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	113					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						CAAATACAAAGTGAGTGCTGG	0.433000													25	82					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53260883	53260883	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:53260883T>C	ENST00000462138.1	-	13	1673	c.1585A>G	c.(1585-1587)Atc>Gtc	p.I529V	TKT_ENST00000423525.2_Missense_Mutation_p.I529V|TKT_ENST00000296289.6_Missense_Mutation_p.I482V|TKT_ENST00000461139.1_5'UTR|TKT_ENST00000423516.1_Missense_Mutation_p.I537V			P29401	TKT_HUMAN	transketolase	529					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	AGCACGCGGATGTTGATCTTT	0.622000													11	32					0	0	1	0	0
SGPP2	130367	broad.mit.edu	37	2	223389711	223389711	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:223389711G>T	ENST00000321276.7	+	4	693	c.607G>T	c.(607-609)Gtg>Ttg	p.V203L		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	203					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TTCCACCTTGGTGTGTCTCAG	0.473000													10	27					0.000673444	0.000708223	1	1	0
NCCRP1	342897	broad.mit.edu	37	19	39691035	39691035	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:39691035C>T	ENST00000339852.4	+	5	620	c.598C>T	c.(598-600)Ctg>Ttg	p.L200L		NM_001001414.1	NP_001001414.1	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	200	FBA.				protein catabolic process					kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	10						GCATGTCTGGCTGCTGGCGGC	0.657000													33	165					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180040050	180040050	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:180040050C>T	ENST00000261937.6	-	25	3470	c.3392G>A	c.(3391-3393)gGc>gAc	p.G1131D	FLT4_ENST00000502649.1_Missense_Mutation_p.G1131D|FLT4_ENST00000393347.3_Missense_Mutation_p.G1131D	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1131	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity	p.G1131D(2)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CATCCTTGTGCCGTCTCTCAG	0.672000													5	103					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959748	157959748	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:157959748C>T	ENST00000389413.3	-	6	888	c.785G>A	c.(784-786)aGc>aAc	p.S262N	PTPRN2_ENST00000404321.2_Missense_Mutation_p.S285N|PTPRN2_ENST00000389418.4_Missense_Mutation_p.S262N|PTPRN2_ENST00000389416.4_Missense_Mutation_p.S245N|PTPRN2_ENST00000409483.1_Missense_Mutation_p.S224N	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	262						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TGGCTCCAGGCTGCCCTCCCC	0.652000													5	14					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2767677	2767677	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:2767677G>A	ENST00000221566.2	-	3	269	c.108C>T	c.(106-108)atC>atT	p.I36I		NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	36					interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGCACTGGATGGCGACTG	0.607000													13	42					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88472718	88472718	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:88472718G>T	ENST00000324166.5	+	1	1740	c.49G>T	c.(49-51)Ggg>Tgg	p.G17W	THNSL2_ENST00000402102.1_Missense_Mutation_p.G17W|THNSL2_ENST00000377254.3_Missense_Mutation_p.G17W|THNSL2_ENST00000358591.2_Missense_Mutation_p.G17W|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000343544.4_Missense_Mutation_p.G17W	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	17					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						CAACTTTGAGGGGGCCCTCTT	0.607000													12	65					1.49906e-05	1.638e-05	1	1	0
DPH7	92715	broad.mit.edu	37	9	140469251	140469251	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr9:140469251C>T	ENST00000277540.2	-	4	577	c.420G>A	c.(418-420)gaG>gaA	p.E140E	DPH7_ENST00000479650.1_5'UTR	NM_138778.2	NP_620133.1			diphthamide biosynthesis 7																		CCAGACACTGCTCCTCCAGGG	0.552000													44	165					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131022867	131022867	+	Silent	SNP	C	C	T	rs146436048		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr9:131022867C>T	ENST00000421699.2	-	17	1566	c.1554G>A	c.(1552-1554)gcG>gcA	p.A518A		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	518						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						TGCGCGCCTCCGCCTGCTCCC	0.667000													110	134					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47408655	47408655	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:47408655C>T	ENST00000398879.1	-	17	1954	c.1588G>A	c.(1588-1590)Ggt>Agt	p.G530S	TNS3_ENST00000311160.9_Missense_Mutation_p.G530S|TNS3_ENST00000355730.3_Missense_Mutation_p.G290S			Q68CZ2	TENS3_HUMAN	tensin 3	530						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GGATCTTCACCAACGTTGCTG	0.632000													14	60					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78329100	78329100	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:78329100T>C	ENST00000255189.3	-	8	1353	c.1325A>G	c.(1324-1326)gAg>gGg	p.E442G	DMGDH_ENST00000380311.4_Missense_Mutation_p.E241G|DMGDH_ENST00000540686.1_Missense_Mutation_p.E62G	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	442					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TGCTTTGGCCTCAGTGTACTG	0.398000													15	41					0	0	1	0	0
SOX17	64321	broad.mit.edu	37	8	55371663	55371663	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:55371663T>C	ENST00000297316.4	+	2	557	c.353T>C	c.(352-354)gTg>gCg	p.V118A		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	118					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			CGGCCCTTCGTGGAGGAGGCA	0.687000													7	22					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178095647	178095647	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:178095647G>A	ENST00000397062.3	-	5	2238	c.1684C>T	c.(1684-1686)Ctc>Ttc	p.L562F	NFE2L2_ENST00000397063.4_Missense_Mutation_p.L546F|NFE2L2_ENST00000464747.1_Missense_Mutation_p.L546F|NFE2L2_ENST00000446151.2_Missense_Mutation_p.L539F	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	562					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AAAACTTCGAGATATAAGGTG	0.363000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			37	59					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	65003880	65003880	+	RNA	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:65003880G>A	ENST00000525437.1	+	0	1297							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						CCCTGTCTAGGCACGCAGATC	0.642000													3	6					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93603706	93603706	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:93603706C>A	ENST00000394236.3	-	12	1674	c.1358G>T	c.(1357-1359)tGg>tTg	p.W453L	PROS1_ENST00000407433.1_Missense_Mutation_p.W322L	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	453	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CATCAAATTCCAGCTTCGTAT	0.363000													3	23					0.115264	0.11736	1	1	0
MS4A2	2206	broad.mit.edu	37	11	59857931	59857931	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:59857931G>T	ENST00000278888.3	+	3	411	c.309G>T	c.(307-309)tgG>tgT	p.W103C		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	103					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	ATCCATTCTGGGGAGCCATAT	0.343000													10	49					1.58986e-06	1.78065e-06	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113170218	113170218	+	Silent	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr9:113170218G>T	ENST00000401783.2	-	38	7998	c.7662C>A	c.(7660-7662)atC>atA	p.I2554I	SVEP1_ENST00000374469.1_Silent_p.I2531I|SVEP1_ENST00000297826.5_Silent_p.I480I	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2554	Sushi 20.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AATCACAGTGGATGGCATTGC	0.493000													12	25					6.42651e-13	7.78129e-13	1	1	0
RP11-383H13.1	0	broad.mit.edu	37	8	72755775	72755775	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:72755775C>A	ENST00000537896.1	+	1	409	c.139C>A	c.(139-141)Cac>Aac	p.H47N	RP11-383H13.1_ENST00000521467.1_Intron|MSC_ENST00000325509.4_Intron																lung(1)	1						CCAGAACCTCCACCCCTTTCG	0.607000											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	16					0.217242	0.218216	1	1	0
FSTL3	10272	broad.mit.edu	37	19	681501	681501	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:681501G>A	ENST00000166139.4	+	4	706	c.674G>A	c.(673-675)cGc>cAc	p.R225H	FSTL3_ENST00000592947.1_3'UTR	NM_005860.2	NP_005851.1	O95633	FSTL3_HUMAN	follistatin-like 3 (secreted glycoprotein)	225	Kazal-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding						all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCACATGCGCCAGGCCACC	0.716000			T	CCND1	B-CLL								7	24					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117969469	117969469	+	Splice_Site	SNP	A	A	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:117969469A>C	ENST00000425217.1	-	11	1697		c.e11+1		KSR2_ENST00000545002.1_Splice_Site|KSR2_ENST00000302438.5_Splice_Site|KSR2_ENST00000339824.5_Splice_Site	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2						intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CATGAAACTCACCTGGGAAGA	0.507000													8	33					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179590206	179590206	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:179590206C>T	ENST00000589042.1	-	71	20949	c.20725G>A	c.(20725-20727)Gtt>Att	p.V6909I	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.V5665I|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V6592I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6592							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGTTGCAACATTTTCCACA	0.418000													11	27					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895775	90895775	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:90895775C>T	ENST00000287934.2	+	1	1993	c.1580C>T	c.(1579-1581)aCc>aTc	p.T527I		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	527					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GGCACCAAGACCGAGAAGCTG	0.582000													25	140					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910587	29910587	+	Nonsense_Mutation	SNP	G	G	T	rs41549014		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:29910587G>T	ENST00000396634.1	+	4	468	c.127G>T	c.(127-129)Gag>Tag	p.E43*	HLA-A_ENST00000376806.5_Nonsense_Mutation_p.E43*|HLA-A_ENST00000376802.2_Nonsense_Mutation_p.E43*|HLA-A_ENST00000376809.5_Nonsense_Mutation_p.E43*			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	43	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.E43*(1)|p.R41fs*31(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						CGGCCGCGGGGAGCCCCGCTT	0.706000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	39					0.184627	0.186291	1	1	0
AFF2	2334	broad.mit.edu	37	X	148037675	148037675	+	Silent	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:148037675T>A	ENST00000370460.2	+	11	2579	c.2100T>A	c.(2098-2100)ccT>ccA	p.P700P	AFF2_ENST00000342251.3_Silent_p.P667P|AFF2_ENST00000286437.5_Silent_p.P341P|AFF2_ENST00000370457.5_Silent_p.P667P	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	700					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGAGGGCCTGGCAAGATTG	0.498000													29	46					0	0	1	0	0
IGKV1-16	28938	broad.mit.edu	37	2	89399811	89399811	+	RNA	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:89399811A>G	ENST00000479981.1	-	0	43																											GAGCTGAGCGAGGACTCTCAT	0.532000													20	55					0	0	1	0	0
CORO2B	10391	broad.mit.edu	37	15	69003107	69003107	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:69003107C>T	ENST00000543950.1	+	4	709	c.355C>T	c.(355-357)Cgg>Tgg	p.R119W	CORO2B_ENST00000540068.1_Missense_Mutation_p.R119W|CORO2B_ENST00000566799.1_Missense_Mutation_p.R124W|CORO2B_ENST00000261861.5_Missense_Mutation_p.R119W	NM_001190457.1	NP_001177386.1	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	124					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			kidney(3)|large_intestine(13)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CGGGCTGAAGCGGAACATGAC	0.657000													3	17					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203847117	203847117	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:203847117A>T	ENST00000320443.8	+	15	3055	c.2012A>T	c.(2011-2013)gAt>gTt	p.D671V	CARF_ENST00000414439.1_Missense_Mutation_p.D569V|CARF_ENST00000438828.2_Missense_Mutation_p.D671V|CARF_ENST00000402905.2_Missense_Mutation_p.D671V|CARF_ENST00000545253.1_Missense_Mutation_p.D583V|CARF_ENST00000545262.1_Missense_Mutation_p.D595V|WDR12_ENST00000477723.1_Intron|CARF_ENST00000428585.1_Missense_Mutation_p.D595V					calcium responsive transcription factor																		CTGTTGGGAGATGTGCAGACT	0.388000													14	39					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102342554	102342554	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:102342554G>T	ENST00000438793.3	+	18	2323	c.1853G>T	c.(1852-1854)gGa>gTa	p.G618V	PAM_ENST00000304400.7_Missense_Mutation_p.G618V|PAM_ENST00000346918.2_Missense_Mutation_p.G618V|PAM_ENST00000455264.2_Missense_Mutation_p.G618V|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000348126.2_Missense_Mutation_p.G511V|PAM_ENST00000274392.9_Missense_Mutation_p.G521V	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	618	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TTAATCCTGGGAAGGAGCATG	0.433000													25	81					1.17739e-12	1.41794e-12	1	1	0
CUBN	8029	broad.mit.edu	37	10	17152949	17152949	+	Silent	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:17152949A>T	ENST00000377833.4	-	9	1049	c.984T>A	c.(982-984)ccT>ccA	p.P328P		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	328	EGF-like 4; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGGAAGACCCAGGTGTATTCA	0.517000													12	52					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91818136	91818136	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:91818136T>C	ENST00000370425.3	-	16	2002	c.1904A>G	c.(1903-1905)tAt>tGt	p.Y635C	HFM1_ENST00000370424.3_Missense_Mutation_p.Y314C|HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	635	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCCTCCAGCATAATGCATTGT	0.358000													7	35					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79350810	79350810	+	Missense_Mutation	SNP	C	C	T	rs140019990		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:79350810C>T	ENST00000419573.3	-	3	671	c.397G>A	c.(397-399)Gcc>Acc	p.A133T	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.A133T	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	133					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGCTCTGTGGCGAGGGTCCTG	0.577000													8	55					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87242429	87242429	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:87242429G>A	ENST00000297524.3	-	1	181	c.78C>T	c.(76-78)atC>atT	p.I26I	SLC7A13_ENST00000520624.1_Intron|SLC7A13_ENST00000419776.2_Silent_p.I26I	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	26						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						CTGCACCAATGATATTAATAA	0.433000													13	73					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054372	29054372	+	Silent	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:29054372A>G	ENST00000377173.2	-	1	718	c.654T>C	c.(652-654)taT>taC	p.Y218Y		NM_001005226.2	NP_001005226.1			olfactory receptor, family 2, subfamily B, member 3											breast(1)|endometrium(1)|kidney(2)|lung(17)|prostate(1)|skin(2)	24						CTATGAAGCCATAGGAGATGA	0.428000													12	60					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52457249	52457249	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:52457249G>A	ENST00000327906.3	+	11	1722	c.1062G>A	c.(1060-1062)aaG>aaA	p.K354K	PHF7_ENST00000478707.1_Silent_p.K354K|PHF7_ENST00000347025.2_Silent_p.K315K	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	354						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		TATTAGAAAAGCCAGAGTCCT	0.498000													13	50					0	0	1	0	0
DMWD	1762	broad.mit.edu	37	19	46289614	46289614	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:46289614G>A	ENST00000270223.6	-	3	1185	c.1140C>T	c.(1138-1140)acC>acT	p.T380T	DMWD_ENST00000377735.3_Silent_p.T380T	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	380					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CTGCCCTTGTGGTGTAGGGGT	0.687000													25	76					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34859817	34859817	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:34859817T>C	ENST00000431794.3	-	20	2471	c.1949A>G	c.(1948-1950)cAt>cGt	p.H650R	MYO19_ENST00000268852.9_Missense_Mutation_p.H450R	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	650	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AGCACTGATATGGATGGTCTC	0.637000													4	10					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77402211	77402211	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:77402211C>A	ENST00000308488.6	-	9	3195	c.2893G>T	c.(2893-2895)Gaa>Taa	p.E965*	RSF1_ENST00000360355.2_Nonsense_Mutation_p.E934*|RSF1_ENST00000480887.1_Nonsense_Mutation_p.E713*			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	965					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TACCTTCGTTCGGCACGCTCT	0.353000													17	57					5.35267e-07	6.02511e-07	1	1	0
OR11H6	122748	broad.mit.edu	37	14	20692042	20692042	+	Silent	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr14:20692042A>G	ENST00000315519.2	+	1	252	c.174A>G	c.(172-174)ctA>ctG	p.L58L		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TGACACTGCTAGGGAATGGAG	0.478000													13	64					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256403	63256403	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:63256403C>T	ENST00000323865.3	-	1	1377	c.1144G>A	c.(1144-1146)Ggc>Agc	p.G382S	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	382					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATTATGGCGCCCAACAGGGTG	0.512000													49	184					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968437	4968437	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrY:4968437C>T	ENST00000333703.4	+	5	3298	c.2785C>T	c.(2785-2787)Cct>Tct	p.P929S	PCDH11Y_ENST00000362095.5_Missense_Mutation_p.P940S|PCDH11Y_ENST00000215473.6_Missense_Mutation_p.P940S	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	940					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						ACTAGACCTTCCTATTGATCT	0.428000													29	33					0	0	1	0	0
FAM20B	9917	broad.mit.edu	37	1	179041168	179041168	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:179041168C>T	ENST00000263733.4	+	8	1455	c.1119C>T	c.(1117-1119)gaC>gaT	p.D373D		NM_014864.3	NP_055679.1	O75063	XYLK_HUMAN	family with sequence similarity 20, member B	373						Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)	14						CTCATCTGGACGCCGTGGACC	0.552000													14	71					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42531679	42531679	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:42531679C>A	ENST00000318522.5	+	17	2217	c.1955C>A	c.(1954-1956)aCg>aAg	p.T652K	EML4_ENST00000401738.3_Missense_Mutation_p.T663K|EML4_ENST00000453191.2_5'UTR|EML4_ENST00000402711.2_Missense_Mutation_p.T594K	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	652					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GCCATAGGAACGCACTCAGGC	0.448000			T	ALK	NSCLC								14	83					3.32936e-07	3.76655e-07	1	1	0
MIR517C	574492	broad.mit.edu	37	19	54244625	54244625	+	RNA	SNP	C	C	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:54244625C>G	ENST00000385103.1	+	0	59					NR_030214.1																						AAGAAAAGATCGTGCATCCTT	0.403000													9	50					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60427861	60427861	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr20:60427861G>C	ENST00000360469.5	+	6	872	c.784G>C	c.(784-786)Gac>Cac	p.D262H	CDH4_ENST00000543233.1_Missense_Mutation_p.D188H	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	262	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GAACCCCATCGACCTGTACAT	0.597000													27	93					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101266634	101266634	+	Silent	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr13:101266634G>T	ENST00000342624.5	-	16	2145	c.1887C>A	c.(1885-1887)gcC>gcA	p.A629A	TMTC4_ENST00000328767.5_Silent_p.A499A|TMTC4_ENST00000376234.3_Silent_p.A610A	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	610						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCAGCACGGTGGCATTTCTCC	0.448000													21	79					9.90768e-06	1.09326e-05	1	1	0
LPCAT3	10162	broad.mit.edu	37	12	7086357	7086357	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:7086357A>T	ENST00000261407.4	-	12	1500	c.1415T>A	c.(1414-1416)aTt>aAt	p.I472N	U47924.19_ENST00000564245.1_RNA|LPCAT3_ENST00000535021.1_5'UTR	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	472					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						TGCTTTGTGAATATAAGGCAA	0.403000													11	42					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64526828	64526828	+	Missense_Mutation	SNP	C	C	A	rs140548078		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:64526828C>A	ENST00000498707.1	-	36	5806	c.5464G>T	c.(5464-5466)Gct>Tct	p.A1822S	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.A1794S	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1822	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GAAAACCCAGCGGCCGTGTAA	0.468000													14	58					0.000151284	0.00016137	1	1	0
DIAPH3	81624	broad.mit.edu	37	13	60566632	60566632	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr13:60566632C>T	ENST00000400324.4	-	10	1320	c.1100G>A	c.(1099-1101)cGt>cAt	p.R367H	DIAPH3_ENST00000465066.1_5'UTR|DIAPH3_ENST00000400319.1_Missense_Mutation_p.R297H|DIAPH3_ENST00000400320.1_Missense_Mutation_p.R321H|DIAPH3_ENST00000400330.1_Missense_Mutation_p.R367H|DIAPH3_ENST00000377908.2_Missense_Mutation_p.R356H|DIAPH3_ENST00000267215.4_Missense_Mutation_p.R367H	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	367	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		CAATCCACAACGCATAAATTC	0.363000													5	16					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74808611	74808611	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:74808611A>T	ENST00000370895.1	+	10	1106	c.1071A>T	c.(1069-1071)caA>caT	p.Q357H	TNNI3K_ENST00000370891.2_Missense_Mutation_p.Q357H|TNNI3K_ENST00000326637.3_Missense_Mutation_p.Q256H|RP11-439H8.4_ENST00000415549.2_RNA|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.Q357H|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.Q357H			Q59H18	TNI3K_HUMAN		256						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										ATCTGCTGCAAAGTGATTTGG	0.393000													9	49					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2694584	2694584	+	Silent	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:2694584G>T	ENST00000399655.1	+	17	2647	c.2382G>T	c.(2380-2382)ccG>ccT	p.P794P	CACNA1C_ENST00000399603.1_Silent_p.P794P|CACNA1C_ENST00000327702.7_Silent_p.P794P|CACNA1C_ENST00000399606.1_Silent_p.P794P|CACNA1C_ENST00000399621.1_Silent_p.P794P|CACNA1C_ENST00000399637.1_Silent_p.P794P|CACNA1C_ENST00000399591.1_Silent_p.P794P|CACNA1C_ENST00000399649.1_Silent_p.P794P|CACNA1C_ENST00000399597.1_Silent_p.P794P|CACNA1C_ENST00000406454.3_Silent_p.P794P|CACNA1C_ENST00000399595.1_Silent_p.P794P|CACNA1C_ENST00000480911.1_Silent_p.P794P|CACNA1C_ENST00000402845.3_Silent_p.P794P|CACNA1C_ENST00000335762.5_Silent_p.P819P|CACNA1C_ENST00000399634.1_Silent_p.P794P|CACNA1C_ENST00000399641.1_Silent_p.P794P|CACNA1C_ENST00000347598.4_Silent_p.P794P|CACNA1C_ENST00000399617.1_Silent_p.P794P|CACNA1C_ENST00000344100.3_Silent_p.P794P|CACNA1C_ENST00000399601.1_Silent_p.P794P|CACNA1C_ENST00000399629.1_Silent_p.P794P|CACNA1C_ENST00000399638.1_Silent_p.P794P|CACNA1C_ENST00000399644.1_Silent_p.P794P	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	794					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGGAGAAGCCGGCAGTGGGGG	0.537000													7	10					0.0477658	0.0493066	1	1	0
COBL	23242	broad.mit.edu	37	7	51093059	51093059	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:51093059G>C	ENST00000395542.2	-	14	3945	c.3761C>G	c.(3760-3762)tCt>tGt	p.S1254C	COBL_ENST00000265136.7_Missense_Mutation_p.S1172C			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1172	WH2 3.									NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CTCAGAAGCAGAGGATGCCAC	0.527000													8	51					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445837	10445837	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:10445837C>G	ENST00000326756.3	-	3	2554	c.2116G>C	c.(2116-2118)Ggt>Cgt	p.G706R		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TCTTGAATACCTTCAGAGGTA	0.463000													16	59					0	0	1	0	0
OR6A2	8590	broad.mit.edu	37	11	6816034	6816034	+	Silent	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:6816034G>T	ENST00000332601.3	-	1	1094	c.906C>A	c.(904-906)gtC>gtA	p.V302V		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGGCTCTCTTGACCTCTTGAT	0.463000													12	60					7.03913e-09	8.16976e-09	1	1	0
BICD1	636	broad.mit.edu	37	12	32481214	32481214	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:32481214T>A	ENST00000548411.1	+	5	2006	c.1825T>A	c.(1825-1827)Tca>Aca	p.S609T	BICD1_ENST00000281474.5_Missense_Mutation_p.S609T	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	609					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			TGCCCCACCGTCATCTCCAGT	0.463000													21	108					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2748564	2748564	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:2748564C>A	ENST00000382611.6	-	3	1506	c.1258G>T	c.(1258-1260)Gcc>Tcc	p.A420S	IRX2_ENST00000302057.5_Missense_Mutation_p.A420S	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	420						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		GTGTGCAGGGCCTCGCCGGGG	0.721000													9	15					3.09899e-07	3.52372e-07	1	1	0
ARF4	378	broad.mit.edu	37	3	57561386	57561386	+	Silent	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:57561386T>C	ENST00000303436.6	-	5	612	c.345A>G	c.(343-345)gaA>gaG	p.E115E	ARF4_ENST00000496292.1_Silent_p.E88E|ARF4_ENST00000489843.1_Silent_p.E6E	NM_001660.3	NP_001651.1	P18085	ARF4_HUMAN	ADP-ribosylation factor 4	115					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus	GTP binding|GTPase activity			large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.0449)|Kidney(284;0.0561)		CATCTCTCAATTCATCTACCA	0.378000													21	53					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245110	59245110	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:59245110G>A	ENST00000530162.1	+	1	265	c.208G>A	c.(208-210)Gat>Aat	p.D70N		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ATCTATTGCCGATATCTGCTT	0.443000													32	103					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25249422	25249422	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:25249422G>A	ENST00000276440.7	+	43	4410	c.4366G>A	c.(4366-4368)Gcc>Acc	p.A1456T		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1456	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CTACTACAGAGCCAATGAAGT	0.438000													6	23					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36156478	36156478	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:36156478T>A	ENST00000378660.1	+	10	1345	c.1157T>A	c.(1156-1158)tTt>tAt	p.F386Y	CHDC2_ENST00000313548.4_Missense_Mutation_p.F386Y					calponin homology domain containing 2																		GAGTCTCATTTTATAAATATG	0.284000													5	3					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25457192	25457192	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:25457192G>A	ENST00000264709.3	-	23	3032	c.2695C>T	c.(2695-2697)Cgc>Tgc	p.R899C	DNMT3A_ENST00000402667.1_Missense_Mutation_p.R676C|DNMT3A_ENST00000321117.5_Missense_Mutation_p.R899C|DNMT3A_ENST00000380746.4_Missense_Mutation_p.R710C	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	899					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGAGGTGGCGGATGACTGGC	0.527000			"""Mis, F, N, S"""		AML								10	47					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798237	140798237	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:140798237G>C	ENST00000398594.2	+	1	811	c.811G>C	c.(811-813)Gag>Cag	p.E271Q	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018927.3	NP_061750.1												p.E271*(1)		central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCAGGACGAGGGCATCAA	0.527000													12	26					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	161771199	161771199	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:161771199C>G	ENST00000366898.1	-	12	1432	c.1330G>C	c.(1330-1332)Gag>Cag	p.E444Q	PARK2_ENST00000338468.3_Missense_Mutation_p.E253Q|PARK2_ENST00000366894.1_Missense_Mutation_p.E253Q|PARK2_ENST00000366896.1_Missense_Mutation_p.E295Q|PARK2_ENST00000366897.1_Missense_Mutation_p.E416Q	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	444					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CAGCACCACTCGAGCCTGCAC	0.627000													6	26					0	0	1	0	0
ZNF473	25888	broad.mit.edu	37	19	50550296	50550296	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:50550296A>T	ENST00000595661.1	+	6	3091	c.2596A>T	c.(2596-2598)Aag>Tag	p.K866*	ZNF473_ENST00000445728.3_Nonsense_Mutation_p.K854*|CTD-2126E3.3_ENST00000599410.1_RNA|ZNF473_ENST00000601364.1_Intron|CTD-2126E3.3_ENST00000599914.1_RNA|ZNF473_ENST00000270617.3_Nonsense_Mutation_p.K866*|ZNF473_ENST00000391821.2_Nonsense_Mutation_p.K866*			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	866					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TGTACACAACAAGCAGCAATA	0.507000											OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	32					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98206024	98206024	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:98206024C>A	ENST00000370192.3	-	4	345	c.245G>T	c.(244-246)tGt>tTt	p.C82F	DPYD_ENST00000306031.5_Missense_Mutation_p.C82F|DPYD_ENST00000423006.2_Missense_Mutation_p.C45F	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	82	4Fe-4S ferredoxin-type 1.				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GGCATCTGCACATTTCAGGCA	0.343000													13	55					9.31168e-06	1.03258e-05	1	1	0
FAR2	55711	broad.mit.edu	37	12	29485551	29485551	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:29485551C>T	ENST00000182377.4	+	11	1544	c.1276C>T	c.(1276-1278)Cgc>Tgc	p.R426C	FAR2_ENST00000547116.1_Missense_Mutation_p.R329C|FAR2_ENST00000536681.2_Missense_Mutation_p.R426C	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	426					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	p.R426C(1)		central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						CTTTGACGTGCGCCAGTTGAA	0.403000													9	39					0	0	1	0	0
MRPS2	51116	broad.mit.edu	37	9	138395634	138395634	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr9:138395634C>T	ENST00000371785.1	+	5	755	c.546C>T	c.(544-546)ctC>ctT	p.L182L	MRPS2_ENST00000241600.5_Silent_p.L182L|MRPS2_ENST00000488610.1_3'UTR|RP11-426A6.5_ENST00000415062.1_RNA			Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	182					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome			large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		CGCGCCTCCTCTTTGGCCCCA	0.607000													19	32					0	0	1	0	0
FARSA	2193	broad.mit.edu	37	19	13035338	13035338	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:13035338T>C	ENST00000588025.1	-	12	1458	c.1318A>G	c.(1318-1320)Atc>Gtc	p.I440V	FARSA_ENST00000423140.2_Missense_Mutation_p.I369V|FARSA_ENST00000314606.4_Missense_Mutation_p.I400V			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	400					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	AGTTGCGTGATACCTGCAGGA	0.612000													23	86					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114069659	114069659	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:114069659C>A	ENST00000462705.1	-	11	1868	c.1047G>T	c.(1045-1047)caG>caT	p.Q349H	ZBTB20_ENST00000481632.1_Missense_Mutation_p.Q349H|ZBTB20_ENST00000471418.1_Missense_Mutation_p.Q349H|ZBTB20_ENST00000393785.2_Missense_Mutation_p.Q349H|ZBTB20_ENST00000357258.3_Missense_Mutation_p.Q349H|ZBTB20_ENST00000474710.1_Missense_Mutation_p.Q422H|ZBTB20_ENST00000464560.1_Missense_Mutation_p.Q349H	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GCTGGTTTGTCTGCGGACCAC	0.617000													18	73					6.94344e-10	8.1431e-10	1	1	0
GRM1	2911	broad.mit.edu	37	6	146673616	146673616	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:146673616G>A	ENST00000392299.2	+	5	1887	c.1417G>A	c.(1417-1419)Gga>Aga	p.G473R	GRM1_ENST00000355289.4_Missense_Mutation_p.G473R|GRM1_ENST00000507907.1_Missense_Mutation_p.G473R|GRM1_ENST00000492807.2_Missense_Mutation_p.G473R|GRM1_ENST00000361719.2_Missense_Mutation_p.G473R|GRM1_ENST00000282753.1_Missense_Mutation_p.G473R			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	473					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGATGAGAAAGGAGACGCTCC	0.493000													27	141					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64418741	64418741	+	Silent	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:64418741G>T	ENST00000265459.6	-	14	3365	c.2904C>A	c.(2902-2904)atC>atA	p.I968I	NRXN2_ENST00000409571.1_Silent_p.I961I|NRXN2_ENST00000377551.1_Silent_p.I968I|NRXN2_ENST00000377559.3_Silent_p.I928I|AP001092.4_ENST00000433606.1_RNA	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	968	Laminin G-like 5.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGACCAGCTCGATGACAATGA	0.577000											OREG0004037|OREG0021057	type=REGULATORY REGION|Gene=AL137356|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	44					0.000673444	0.000708223	1	1	0
NPLOC4	55666	broad.mit.edu	37	17	79526391	79526391	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:79526391C>A	ENST00000331134.6	-	17	1936	c.1721G>T	c.(1720-1722)gGc>gTc	p.G574V	NPLOC4_ENST00000572760.1_Missense_Mutation_p.A39S|NPLOC4_ENST00000573876.1_Missense_Mutation_p.A39S	NM_017921.2	NP_060391.2	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	574					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GTGTGTGGAGCCCCCGACGGC	0.632000													6	17					0.00116845	0.00122305	1	1	0
C12orf4	57102	broad.mit.edu	37	12	4639058	4639058	+	Silent	SNP	C	C	T	rs144033494		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:4639058C>T	ENST00000261250.3	-	4	570	c.483G>A	c.(481-483)gtG>gtA	p.V161V	C12orf4_ENST00000545746.1_Silent_p.V161V	NM_020374.2	NP_065107.1	Q9NQ89	CL004_HUMAN	chromosome 12 open reading frame 4	161										NS(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		TTTTCAGCTCCACATCTCTTT	0.333000													8	42					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102567145	102567145	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:102567145C>T	ENST00000260229.4	-	6	950	c.859G>A	c.(859-861)Gct>Act	p.A287T		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	287	Hemopexin-like 1.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GTTGTGATAGCGTCAAAAGTC	0.408000													7	53					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46496942	46496942	+	Missense_Mutation	SNP	G	G	A	rs56114653		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:46496942G>A	ENST00000361297.2	+	23	3255	c.2972G>A	c.(2971-2973)cGg>cAg	p.R991Q	MAST2_ENST00000372009.2_Missense_Mutation_p.R921Q|MAST2_ENST00000372008.1_Intron	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	991			R -> L (in dbSNP:rs56114653).		regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GCTGTTGGCCGGAGCAGTGGT	0.622000													3	40					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169509963	169509963	+	Silent	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:169509963T>C	ENST00000367796.3	-	13	4581	c.4380A>G	c.(4378-4380)tcA>tcG	p.S1460S	F5_ENST00000367797.3_Silent_p.S1455S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1455	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTGGAGGAGGTGATATCTGGC	0.473000													18	41					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545411	82545411	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:82545411C>A	ENST00000423517.2	-	7	12228	c.11891G>T	c.(11890-11892)cGg>cTg	p.R3964L	PCLO_ENST00000437081.1_Missense_Mutation_p.R684L|PCLO_ENST00000333891.8_Missense_Mutation_p.R3964L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3895					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.R3964L(2)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGTAGTTTGCCGTGGCTTCTG	0.433000													134	270					6.4993e-71	8.3191e-71	1	1	0
RIMS2	9699	broad.mit.edu	37	8	104709402	104709402	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:104709402G>T	ENST00000406091.3	+	2	265	c.265G>T	c.(265-267)Gcg>Tcg	p.A89S		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	120	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAAGGGTGATGCGCCAACCTG	0.438000										HNSCC(12;0.0054)			16	80					8.60227e-14	1.05874e-13	1	1	0
TNFRSF25	8718	broad.mit.edu	37	1	6526162	6526162	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:6526162C>T	ENST00000377782.3	-	1	73	c.6G>A	c.(4-6)gaG>gaA	p.E2E	PLEKHG5_ENST00000377748.1_3'UTR|TNFRSF25_ENST00000461703.2_5'UTR|PLEKHG5_ENST00000400913.1_3'UTR|PLEKHG5_ENST00000340850.5_3'UTR|TNFRSF25_ENST00000348333.3_Silent_p.E2E|TNFRSF25_ENST00000356876.3_Silent_p.E2E|TNFRSF25_ENST00000351748.3_Silent_p.E2E|TNFRSF25_ENST00000351959.5_Silent_p.E2E	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	2					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GCGGCCGCTGCTCCATAGCCC	0.746000													6	10					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195706702	195706702	+	RNA	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:195706702G>A	ENST00000427841.1	-	0	934					NR_003264.2																						GTGCTGGTGTGGGCAGACGTG	0.597000													6	22					0	0	1	0	0
C12orf44	60673	broad.mit.edu	37	12	52470570	52470570	+	Splice_Site	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:52470570G>T	ENST00000336854.4	+	4	731	c.252_splice	c.e4-1	p.D85_splice		NM_001098673.1|NM_021934.4	NP_001092143.1|NP_068753.2	Q9BSB4	ATGA1_HUMAN	chromosome 12 open reading frame 44	85					autophagic vacuole assembly	pre-autophagosomal structure	identical protein binding|protein complex binding			endometrium(1)|lung(2)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(357;0.0978)		TTCTTCCCAGGATGCACTGCG	0.567000													4	35					1.024e-07	1.17629e-07	1	1	0
TUBGCP3	10426	broad.mit.edu	37	13	113174235	113174235	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr13:113174235C>T	ENST00000261965.3	-	15	2032	c.1846G>A	c.(1846-1848)Gag>Aag	p.E616K	TUBGCP3_ENST00000375669.3_Missense_Mutation_p.E616K	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	616					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CGCAGGATCTCAGGACTGTCA	0.592000													28	74					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28250550	28250550	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:28250550C>A	ENST00000305242.5	-	10	1425	c.1333G>T	c.(1333-1335)Gca>Tca	p.A445S	ARMC4_ENST00000239715.3_Missense_Mutation_p.A302S|ARMC4_ENST00000537576.1_Missense_Mutation_p.A137S|ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000545014.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	445							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GGCAAATCTGCACTTGCTTCC	0.388000													4	37					0.184627	0.186291	1	1	0
SDSL	113675	broad.mit.edu	37	12	113873329	113873329	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:113873329C>T	ENST00000403593.4	+	6	901	c.639C>T	c.(637-639)gcC>gcT	p.A213A	SDSL_ENST00000345635.4_Silent_p.A213A			Q96GA7	SDSL_HUMAN	serine dehydratase-like	213					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	CCATCACAGCCGGCAAGCTGG	0.627000													22	94					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38320186	38320186	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr13:38320186G>A	ENST00000379705.3	-	3	1642	c.785C>T	c.(784-786)tCc>tTc	p.S262F	TRPC4_ENST00000379681.3_Missense_Mutation_p.S262F|TRPC4_ENST00000379673.2_Missense_Mutation_p.S262F|TRPC4_ENST00000355779.2_Missense_Mutation_p.S262F|TRPC4_ENST00000338947.5_Intron|TRPC4_ENST00000379679.1_Intron|TRPC4_ENST00000426868.2_Missense_Mutation_p.S262F|TRPC4_ENST00000447043.1_Missense_Mutation_p.S262F|TRPC4_ENST00000358477.2_Missense_Mutation_p.S262F			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	262	Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CAGTTCTCTGGAACTTCTCGT	0.403000													22	106					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204078257	204078257	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:204078257A>T	ENST00000449802.1	+	54	8197	c.7864A>T	c.(7864-7866)Aac>Tac	p.N2622Y		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2622							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TCTCAGCATCAACCCATTAGC	0.328000													30	37					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53581597	53581597	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:53581597T>C	ENST00000342160.3	-	60	8948	c.8491A>G	c.(8491-8493)Ata>Gta	p.I2831V	HUWE1_ENST00000262854.6_Missense_Mutation_p.I2831V			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2831					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TACTCACTTATAGTGGGAGCT	0.448000													4	6					0	0	1	0	0
TTC14	151613	broad.mit.edu	37	3	180320144	180320144	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:180320144G>T	ENST00000412756.2	+	1	164	c.95G>T	c.(94-96)cGt>cTt	p.R32L	TTC14_ENST00000296015.4_Missense_Mutation_p.R32L|TTC14_ENST00000382584.4_Missense_Mutation_p.R32L	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	32							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CCACACTTCCGTAGCCTCCTG	0.647000													3	24					0.115264	0.11736	1	1	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139121	90139121	+	RNA	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:90139121T>C	ENST00000492446.1	+	0	44																											ATGAGGGTCCTCGCTCAGCTC	0.537000													15	119					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241439473	241439473	+	Missense_Mutation	SNP	C	C	A	rs141314665	byFrequency	TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:241439473C>A	ENST00000391987.1	-	15	2807	c.2441G>T	c.(2440-2442)cGg>cTg	p.R814L	ANKMY1_ENST00000272972.3_Missense_Mutation_p.R814L|ANKMY1_ENST00000373318.2_Missense_Mutation_p.R593L|ANKMY1_ENST00000373320.4_Missense_Mutation_p.R584L|ANKMY1_ENST00000361678.4_Missense_Mutation_p.R590L|ANKMY1_ENST00000406958.1_Missense_Mutation_p.R575L|ANKMY1_ENST00000403283.1_Missense_Mutation_p.R716L|ANKMY1_ENST00000401804.1_Missense_Mutation_p.R903L			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	814							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GAGCCGCTTCCGCGCCAGGAA	0.652000													7	17					1	1	1	1	0
POM121L12	285877	broad.mit.edu	37	7	53104138	53104138	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:53104138G>T	ENST00000408890.4	+	1	790	c.774G>T	c.(772-774)caG>caT	p.Q258H		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	258										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						TGCTGGTCCAGCCCGCCCCAT	0.652000													29	77					5.60225e-13	6.82013e-13	1	1	0
CLNK	116449	broad.mit.edu	37	4	10533898	10533898	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:10533898G>A	ENST00000226951.6	-	12	851	c.612C>T	c.(610-612)agC>agT	p.S204S	CLNK_ENST00000442825.2_Silent_p.S162S|CLNK_ENST00000507719.1_Silent_p.S162S	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	204					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						AGTCCCTTAAGCTTATCTGAC	0.343000													5	10					0	0	1	0	0
ZNF280D	54816	broad.mit.edu	37	15	56974508	56974508	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:56974508C>T	ENST00000559237.1	-	9	1592	c.909G>A	c.(907-909)aaG>aaA	p.K303K	ZNF280D_ENST00000559000.1_Silent_p.K303K|ZNF280D_ENST00000396245.1_Silent_p.K20K|ZNF280D_ENST00000267807.7_Silent_p.K316K	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		TTGTGTGAGTCTTCTGTTCCT	0.284000													3	30					0	0	1	0	0
ALX3	257	broad.mit.edu	37	1	110607340	110607340	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:110607340G>T	ENST00000369792.4	-	2	550	c.463C>A	c.(463-465)Cgt>Agt	p.R155S		NM_006492.2	NP_006483.2	O95076	ALX3_HUMAN	ALX homeobox 3	155						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(81;2.35e-05)|all_epithelial(167;7.69e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.015)|all cancers(265;0.0706)|Epithelial(280;0.0758)|Colorectal(144;0.113)|LUSC - Lung squamous cell carcinoma(189;0.135)		GTGCGGTTACGACGCTTCTTG	0.597000													19	67					1.56452e-12	1.87408e-12	1	1	0
PPEF2	5470	broad.mit.edu	37	4	76805746	76805746	+	Splice_Site	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:76805746C>T	ENST00000286719.7	-	8	1103		c.e8+1			NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2						detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTGACTTGTACCGTAAGTTCA	0.353000													29	112					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62438566	62438566	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:62438566C>T	ENST00000541428.1	-	22	1943	c.1783G>A	c.(1783-1785)Gac>Aac	p.D595N	ASPH_ENST00000379454.4_Missense_Mutation_p.D624N	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	624					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TGGCTCCAGTCCCCTTTTTCC	0.493000													14	110					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152490306	152490306	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:152490306C>A	ENST00000397345.3	-	65	9478	c.9276G>T	c.(9274-9276)atG>atT	p.M3092I	NEB_ENST00000603639.1_Missense_Mutation_p.M3092I|NEB_ENST00000172853.10_Intron|NEB_ENST00000427231.2_Missense_Mutation_p.M3092I|NEB_ENST00000604864.1_Missense_Mutation_p.M3092I|NEB_ENST00000409198.1_Intron	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	3092					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCACCCCCAGCATGTCCACTG	0.532000													104	177					7.43007e-68	9.45646e-68	1	1	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458436	45458436	+	RNA	SNP	T	T	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:45458436T>G	ENST00000548424.1	+	0	448																											GTCTCAATAGTGGGCACAGCT	0.527000													5	22					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16360435	16360435	+	Missense_Mutation	SNP	C	C	T	rs143610596	byFrequency	TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr20:16360435C>T	ENST00000354981.2	-	19	2369	c.2212G>A	c.(2212-2214)Gat>Aat	p.D738N	KIF16B_ENST00000408042.1_Missense_Mutation_p.D738N|KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000355755.3_Missense_Mutation_p.D738N	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	738	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TACTGTTCATCTTTTTCCTTT	0.468000													18	91					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480884	57480884	+	Silent	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:57480884A>G	ENST00000371236.2	-	12	1379	c.1116T>C	c.(1114-1116)gtT>gtC	p.V372V	DAB1_ENST00000439789.2_Silent_p.V286V|DAB1_ENST00000420954.2_Silent_p.V370V|DAB1_ENST00000371234.4_Silent_p.V372V|DAB1_ENST00000371231.1_Silent_p.V405V|DAB1_ENST00000414851.2_Silent_p.V354V|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	405					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCAAAGGCATAACAGTTTGTG	0.632000													31	85					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37713740	37713740	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr21:37713740G>A	ENST00000400485.1	+	6	728	c.652G>A	c.(652-654)Gat>Aat	p.D218N	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	218					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						GGATAAATATGATATCAGAAT	0.373000													6	33					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55194253	55194253	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:55194253C>A	ENST00000337714.3	+	8	2698	c.2465C>A	c.(2464-2466)gCa>gAa	p.A822E	AKAP1_ENST00000539273.1_Missense_Mutation_p.A822E|AKAP1_ENST00000571629.1_Missense_Mutation_p.A822E|AKAP1_ENST00000572557.1_Missense_Mutation_p.A822E	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	822					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					TTTCAGGGAGCAGAAGTCCTT	0.512000													12	84					0.000151284	0.00016137	1	1	0
ARHGAP32	9743	broad.mit.edu	37	11	128839322	128839322	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:128839322G>A	ENST00000310343.9	-	22	5743	c.5744C>T	c.(5743-5745)tCt>tTt	p.S1915F	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.S1566F|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.S1566F|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1915	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GACTGGCTCAGAAGTGTCTGG	0.493000													20	80					0	0	1	0	0
RASD2	23551	broad.mit.edu	37	22	35947786	35947786	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr22:35947786G>T	ENST00000216127.4	+	3	1150	c.508G>T	c.(508-510)Gag>Tag	p.E170*		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	170					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						CGCCTACTTCGAGGTGTCGGC	0.622000													8	19					0.000157383	0.00016708	1	1	0
CASP8	841	broad.mit.edu	37	2	202149973	202149973	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:202149973C>T	ENST00000358485.4	+	8	1610	c.1414C>T	c.(1414-1416)Cga>Tga	p.R472*	CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000264275.5_Nonsense_Mutation_p.R430*|CASP8_ENST00000264274.9_Nonsense_Mutation_p.R329*|CASP8_ENST00000432109.2_Nonsense_Mutation_p.R413*|CASP8_ENST00000323492.7_Nonsense_Mutation_p.R398*|CASP8_ENST00000392259.2_3'UTR	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	413					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						TGTTTCCTACCGAAACCCTGC	0.488000										HNSCC(4;0.00038)			26	27					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57837890	57837890	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:57837890A>T	ENST00000281282.5	+	17	3679	c.3601A>T	c.(3601-3603)Aag>Tag	p.K1201*		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	1201						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GACTGATCAGAAGGACCAGGT	0.582000													6	17					0	0	1	0	0
ZNF684	127396	broad.mit.edu	37	1	41012488	41012488	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:41012488G>T	ENST00000372699.3	+	5	744	c.493G>T	c.(493-495)Ggg>Tgg	p.G165W	ZNF684_ENST00000493756.1_3'UTR	NM_152373.3	NP_689586.3	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|lung(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			CAGTGAATGCGGGAAAGCCTT	0.318000													10	24					6.40141e-05	6.92713e-05	1	1	0
SLC5A5	6528	broad.mit.edu	37	19	17988632	17988632	+	Missense_Mutation	SNP	C	C	A	rs121909176		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:17988632C>A	ENST00000222248.3	+	6	1146	c.799C>A	c.(799-801)Cag>Aag	p.Q267K		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	267			Q -> E (in TDH1).		cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						GGCGCAGGTGCAGCGCTACGT	0.607000													26	89					1.12875e-08	1.3033e-08	1	1	0
COL8A1	1295	broad.mit.edu	37	3	99513727	99513727	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:99513727G>A	ENST00000261037.3	+	5	1362	c.982G>A	c.(982-984)Gga>Aga	p.G328R	COL8A1_ENST00000273342.4_Missense_Mutation_p.G328R	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	328	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						AGGCCAGCCAGGATTTCCAGG	0.622000													9	46					0	0	1	0	0
SPATA9	83890	broad.mit.edu	37	5	94994441	94994441	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:94994441C>T	ENST00000274432.8	-	5	792	c.651G>A	c.(649-651)ccG>ccA	p.P217P	SPATA9_ENST00000477047.2_Intron|RFESD_ENST00000508206.1_Intron	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	217					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		CTGGCTTCTCCGGCAATGACC	0.403000													7	27					0	0	1	0	0
PQLC1	80148	broad.mit.edu	37	18	77664035	77664035	+	Missense_Mutation	SNP	G	G	A	rs148418095	byFrequency	TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr18:77664035G>A	ENST00000397778.2	-	6	939	c.757C>T	c.(757-759)Cgc>Tgc	p.R253C	PQLC1_ENST00000590381.1_3'UTR|PQLC1_ENST00000409073.1_Missense_Mutation_p.R170C|PQLC1_ENST00000357575.4_Missense_Mutation_p.R235C|PQLC1_ENST00000590895.1_5'UTR	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	253						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TGGGGGTGGCGGGCGAAGGCG	0.706000													6	23					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140793473	140793473	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:140793473C>T	ENST00000398610.2	+	1	731	c.731C>T	c.(730-732)cCg>cTg	p.P244L	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAACGCGCCGGTCTTCACC	0.582000													12	40					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86258661	86258661	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:86258661C>T	ENST00000263857.6	-	30	4748	c.4370G>A	c.(4369-4371)cGa>cAa	p.R1457Q	POLR1A_ENST00000409681.1_Missense_Mutation_p.R1457Q			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1457					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						TTGGGTCTTTCGAGCACCTTC	0.592000													22	78					0	0	1	0	0
CPT1B	1375	broad.mit.edu	37	22	51011377	51011377	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr22:51011377A>G	ENST00000360719.2	-	11	1416	c.1279T>C	c.(1279-1281)Tcc>Ccc	p.S427P	CPT1B_ENST00000440709.1_Intron|CPT1B_ENST00000405237.3_Missense_Mutation_p.S427P|CPT1B_ENST00000312108.7_Missense_Mutation_p.S427P|CPT1B_ENST00000457250.1_Missense_Mutation_p.S393P|CPT1B_ENST00000395650.2_Missense_Mutation_p.S427P|CHKB-CPT1B_ENST00000453634.1_3'UTR|CPT1B_ENST00000434492.2_Missense_Mutation_p.S224P	NM_001145135.1|NM_152245.2	NP_001138607.1|NP_689451.1	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B (muscle)	427			S -> C (in dbSNP:rs8142477).		carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		GGGTCATAGGAGTAGGATTCC	0.587000													27	127					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196726634	196726634	+	Silent	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:196726634G>T	ENST00000312428.6	-	42	7643	c.7543C>A	c.(7543-7545)Cga>Aga	p.R2515R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2515	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCAAGAATCGTGAGGCAACT	0.378000													16	24					1.33834e-09	1.56139e-09	1	1	0
PIK3CG	5294	broad.mit.edu	37	7	106508689	106508689	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:106508689C>T	ENST00000359195.3	+	2	993	c.683C>T	c.(682-684)aCc>aTc	p.T228I	PIK3CG_ENST00000496166.1_Missense_Mutation_p.T228I|PIK3CG_ENST00000440650.2_Missense_Mutation_p.T228I	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	228					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						CACCGCAGCACCACCAGCCAG	0.557000													53	81					0	0	1	0	0
HAS3	3038	broad.mit.edu	37	16	69143484	69143484	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr16:69143484T>A	ENST00000306560.1	+	2	342	c.186T>A	c.(184-186)ttT>ttA	p.F62L	HAS3_ENST00000569188.1_Missense_Mutation_p.F62L|HAS3_ENST00000219322.3_Missense_Mutation_p.F62L	NM_005329.2	NP_005320.2	O00219	HAS3_HUMAN	hyaluronan synthase 3	62					carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(2)	16		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		AGAGCCTTTTTGCCTTCCTGG	0.647000													10	52					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35608173	35608173	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr8:35608173T>A	ENST00000287272.2	+	12	1822	c.1802T>A	c.(1801-1803)cTg>cAg	p.L601Q	UNC5D_ENST00000404895.2_Missense_Mutation_p.L670Q|UNC5D_ENST00000420357.1_Missense_Mutation_p.L603Q|UNC5D_ENST00000453357.2_Missense_Mutation_p.L665Q|UNC5D_ENST00000449677.1_Missense_Mutation_p.L246Q|UNC5D_ENST00000416672.1_Missense_Mutation_p.L675Q			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	670	ZU5.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CATGTGCTCCTGGACAGCTTT	0.498000													40	98					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296997	29296997	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:29296997A>T	ENST00000331664.5	-	1	130	c.131T>A	c.(130-132)cTg>cAg	p.L44Q		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	44					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GTTTTTAACCAGCAAAGGGAT	0.522000													11	40					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164714334	164714334	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:164714334C>T	ENST00000264382.3	-	40	4743	c.4681G>A	c.(4681-4683)Gca>Aca	p.A1561T		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1561	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTAGTATTTGCAATGTTGTGA	0.363000										HNSCC(35;0.089)			9	25					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9512475	9512475	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:9512475T>A	ENST00000402466.1	+	20	3531	c.2763T>A	c.(2761-2763)tgT>tgA	p.C921*	SETD5_ENST00000406341.1_Nonsense_Mutation_p.C1019*|SETD5_ENST00000302463.6_Nonsense_Mutation_p.C921*|SETD5_ENST00000402198.1_Nonsense_Mutation_p.C1019*|SETD5_ENST00000407969.1_Nonsense_Mutation_p.C1038*			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1019										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		GGGGATATTGTTCCCCTGCAG	0.498000													5	20					0	0	1	0	0
ZFYVE27	118813	broad.mit.edu	37	10	99512621	99512621	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:99512621A>T	ENST00000393677.4	+	9	1088	c.884A>T	c.(883-885)cAc>cTc	p.H295L	ZFYVE27_ENST00000357540.4_Intron|ZFYVE27_ENST00000356257.4_Missense_Mutation_p.H300L|ZFYVE27_ENST00000337540.7_Intron|ZFYVE27_ENST00000370613.3_Intron|ZFYVE27_ENST00000370610.3_Intron|ZFYVE27_ENST00000359980.3_Intron|ZFYVE27_ENST00000453958.2_Intron	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	295					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		CAGGAGACCCACTTGGTGGTG	0.617000													7	45					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126239890	126239890	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:126239890A>T	ENST00000394329.3	+	1	2337	c.2324A>T	c.(2323-2325)aAc>aTc	p.N775I		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	775	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAATCTCCCAACCAGGCAATA	0.438000													14	54					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28539706	28539706	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:28539706T>A	ENST00000452236.2	-	4	4577	c.3960A>T	c.(3958-3960)caA>caT	p.Q1320H		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1320					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ataagtgagcttgcttcttgc	0.308000													11	20					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3979344	3979344	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:3979344C>T	ENST00000309311.6	-	11	1784	c.1696G>A	c.(1696-1698)Gcc>Acc	p.A566T		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	566						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGATGCAGGCGTGGTCCTCC	0.632000													24	116					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139796841	139796841	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr7:139796841T>C	ENST00000397560.2	-	16	2120	c.2023A>G	c.(2023-2025)Atc>Gtc	p.I675V	JHDM1D_ENST00000006967.5_Missense_Mutation_p.I675V	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		675					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					GTGGTAAAGATACTTTTCTGA	0.328000													8	10					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65438991	65438991	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:65438991C>A	ENST00000330909.8	-	6	983	c.984G>T	c.(982-984)tgG>tgT	p.W328C	MAGI1_ENST00000402939.2_Missense_Mutation_p.W328C|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000483466.1_Missense_Mutation_p.W328C|MAGI1_ENST00000497477.2_Missense_Mutation_p.W328C	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	328	WW 1.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GAGGGTCTAACCAAGATGTTG	0.423000													12	59					6.40141e-05	6.92713e-05	1	1	0
HCN1	348980	broad.mit.edu	37	5	45262714	45262714	+	Missense_Mutation	SNP	C	C	G	rs143224211		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:45262714C>G	ENST00000303230.4	-	8	2039	c.1982G>C	c.(1981-1983)aGg>aCg	p.R661T		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	661						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AGATTGTGTCCTCATGCGGGA	0.572000													13	43					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786351	112786351	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:112786351C>T	ENST00000295408.4	+	19	3167	c.2910C>T	c.(2908-2910)tcC>tcT	p.S970S	MERTK_ENST00000409780.1_Silent_p.S794S|MERTK_ENST00000421804.2_Silent_p.S970S			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	970					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TCTCCTGGTCCCATTCGAGCA	0.527000													19	26					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999853	112999853	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:112999853C>T	ENST00000271277.6	+	6	1964	c.1739C>T	c.(1738-1740)cCa>cTa	p.P580L	CTTNBP2NL_ENST00000607039.1_3'UTR|RP4-671G15.3_ENST00000508462.1_RNA	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	580						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAAACCCTCCACCCATCCCA	0.562000													19	61					0	0	1	0	0
TRIM43	129868	broad.mit.edu	37	2	96260870	96260870	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:96260870G>A	ENST00000272395.2	+	3	620	c.484G>A	c.(484-486)Gga>Aga	p.G162R		NM_001164464.1|NM_138800.1	NP_001157936.1|NP_620155.1	Q96BQ3	TRI43_HUMAN	tripartite motif containing 43	162						intracellular	zinc ion binding	p.G162R(2)		breast(1)|large_intestine(3)|lung(7)|ovary(1)	12						ATATGAGGAGGGAAGAACAGC	0.398000													3	20					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48327856	48327856	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr18:48327856A>G	ENST00000428869.2	-	7	706	c.448T>C	c.(448-450)Tac>Cac	p.Y150H	MRO_ENST00000588444.1_Intron|MRO_ENST00000256425.2_Missense_Mutation_p.Y150H|MRO_ENST00000398439.3_Missense_Mutation_p.Y150H|MRO_ENST00000431965.2_Intron|MRO_ENST00000587291.1_5'UTR|MRO_ENST00000436348.2_Missense_Mutation_p.Y164H			Q9BYG7	MSTRO_HUMAN	maestro	150						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		AAGGCCGAGTATCTCAGACTG	0.468000													41	165					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	115					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768178	31768178	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:31768178C>A	ENST00000240587.4	-	2	2848	c.2521G>T	c.(2521-2523)Gag>Tag	p.E841*		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	841					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AAGGCATTCTCGCGTAGCGGC	0.522000													24	72					9.39395e-14	1.14986e-13	1	1	0
DPPA2	151871	broad.mit.edu	37	3	109023515	109023515	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:109023515C>T	ENST00000478945.1	-	7	907	c.661G>A	c.(661-663)Gtc>Atc	p.V221I		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	221						nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CACCACCTGACGCCTGGAAAG	0.498000													14	50					0	0	1	0	0
IKZF5	64376	broad.mit.edu	37	10	124754116	124754116	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:124754116C>T	ENST00000368886.5	-	5	760	c.440G>A	c.(439-441)tGc>tAc	p.C147Y	PSTK_ENST00000497219.1_Intron	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		TCGATCACTGCAGCGGAAGGA	0.433000													6	50					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162865771	162865771	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:162865771G>A	ENST00000360534.3	-	21	2427	c.1867C>T	c.(1867-1869)Cga>Tga	p.R623*	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	623					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	ATTGCAATTCGTTTGTTGTCC	0.368000													24	24					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198949847	198949847	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:198949847A>T	ENST00000428675.1	+	2	2004	c.1606A>T	c.(1606-1608)Atg>Ttg	p.M536L	PLCL1_ENST00000437704.2_Missense_Mutation_p.M438L	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	536	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	ATTAAAAAGAATGATCATTGT	0.393000													22	28					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129030413	129030413	+	Splice_Site	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:129030413G>A	ENST00000274487.4	+	19	2946	c.2800_splice	c.e19-1	p.G934_splice	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	934	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TTCTTTTCAGGAGAAAGGAAG	0.313000													6	38					0	0	1	0	0
CTDSPL2	51496	broad.mit.edu	37	15	44789262	44789262	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:44789262G>A	ENST00000260327.4	+	7	1371	c.808G>A	c.(808-810)Gaa>Aaa	p.E270K	CTDSPL2_ENST00000558373.1_Missense_Mutation_p.E198K|CTDSPL2_ENST00000561189.1_3'UTR|CTDSPL2_ENST00000396780.1_Missense_Mutation_p.E198K|CTDSPL2_ENST00000558966.1_Missense_Mutation_p.E270K	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	270							phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		ACTGACAGAAGAACAACTAAA	0.323000													15	58					0	0	1	0	0
HDGFL1	154150	broad.mit.edu	37	6	22569841	22569841	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:22569841G>A	ENST00000510882.2	+	1	47	c.37G>A	c.(37-39)Gac>Aac	p.D13N	HDGFL1_ENST00000230012.3_Missense_Mutation_p.D13N			Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	13	PWWP.									kidney(1)|large_intestine(3)|lung(7)	11	Ovarian(93;0.163)					CAAGAGCGGGGACCTGGTGTT	0.622000													9	49					0	0	1	0	0
ECM1	1893	broad.mit.edu	37	1	150482213	150482213	+	Silent	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:150482213C>T	ENST00000369047.4	+	3	323	c.198C>T	c.(196-198)ggC>ggT	p.G66G	ECM1_ENST00000470432.1_3'UTR|ECM1_ENST00000369049.4_Silent_p.G66G|ECM1_ENST00000346569.6_Silent_p.G66G	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	66					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTCAGCATGGCCCTCCCTTTG	0.572000													27	117					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131666136	131666136	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr10:131666136C>A	ENST00000368648.3	-	9	867	c.795G>T	c.(793-795)tgG>tgT	p.W265C	EBF3_ENST00000355311.5_Missense_Mutation_p.W274C	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	274	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding	p.W265C(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCCCCGTGGTCCAGCCTTCAC	0.587000													18	56					1.15919e-05	1.27283e-05	1	1	0
HNRNPUL1	11100	broad.mit.edu	37	19	41812381	41812381	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:41812381C>T	ENST00000392006.3	+	15	2655	c.2482C>T	c.(2482-2484)Cag>Tag	p.Q828*	HNRNPUL1_ENST00000352456.3_Nonsense_Mutation_p.Q738*|HNRNPUL1_ENST00000378215.4_Nonsense_Mutation_p.Q724*|HNRNPUL1_ENST00000263367.3_Nonsense_Mutation_p.Q739*|HNRNPUL1_ENST00000602130.1_Nonsense_Mutation_p.Q776*|HNRNPUL1_ENST00000593587.1_Nonsense_Mutation_p.Q728*|HNRNPUL1_ENST00000595018.1_Nonsense_Mutation_p.Q728*	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	828	Gln-rich.|Necessary for interaction with TP53.|Tyr-rich.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						CCAGTACTATCAGAACCAGGG	0.567000													32	85					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56904621	56904621	+	Silent	SNP	C	C	T	rs140167332		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr16:56904621C>T	ENST00000438926.2	+	6	854	c.825C>T	c.(823-825)tcC>tcT	p.S275S	SLC12A3_ENST00000566786.1_Silent_p.S274S|SLC12A3_ENST00000563236.1_Silent_p.S275S|SLC12A3_ENST00000262502.5_Silent_p.S274S	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	275					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TGGCCATCTCCCTGGCTGGCA	0.632000													5	35					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													4	135					0	0	1	0	0
PDZD11	51248	broad.mit.edu	37	X	69507127	69507127	+	Splice_Site	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:69507127G>A	ENST00000239666.4	-	6	519	c.388_splice	c.e6+1	p.Y129_splice	PDZD11_ENST00000374454.1_Splice_Site_p.Y129_splice	NM_016484.4	NP_057568.1	Q5EBL8	PDZ11_HUMAN	PDZ domain containing 11	129	PDZ.					basolateral plasma membrane|cytosol|extracellular region	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(3)|lung(3)	9						GGCACTTACTGTAGGGAAAGA	0.448000													7	14					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33077107	33077107	+	Silent	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr20:33077107A>G	ENST00000374864.4	+	21	2343	c.2130A>G	c.(2128-2130)gaA>gaG	p.E710E	ITCH_ENST00000535650.1_Silent_p.E600E|ITCH_ENST00000262650.6_Silent_p.E751E	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	751	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GAGGTGTTGAAGAACAGACAC	0.348000													12	41					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127768624	127768624	+	Silent	SNP	C	C	T	rs138966810		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:127768624C>T	ENST00000483725.3	-	5	1176	c.840G>A	c.(838-840)tcG>tcA	p.S280S	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	280							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		GTTCAGAATCCGAGCTGGGAA	0.428000													22	89					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21478515	21478515	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:21478515G>T	ENST00000281523.2	-	5	1138	c.620C>A	c.(619-621)tCg>tAg	p.S207*	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	207						nucleus	nucleic acid binding|zinc ion binding	p.S207L(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						CTTGCATAGCGAACAGTAAAG	0.478000													19	81					3.62473e-10	4.27337e-10	1	1	0
SH2D1A	4068	broad.mit.edu	37	X	123499672	123499672	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:123499672G>A	ENST00000371139.4	+	2	498	c.199G>A	c.(199-201)Gag>Aag	p.E67K	SH2D1A_ENST00000470647.1_3'UTR|SH2D1A_ENST00000360027.4_Missense_Mutation_p.E67K|STAG2_ENST00000469481.1_Intron	NM_001114937.2|NM_002351.4	NP_001108409.1|NP_002342.1	O60880	SH21A_HUMAN	SH2 domain containing 1A	67	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						TTGGAGTGCTGAGGTATAGTT	0.348000													24	37					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73986653	73986653	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:73986653G>A	ENST00000358602.4	-	20	3910	c.3794C>T	c.(3793-3795)aCt>aTt	p.T1265I	ANKRD17_ENST00000330838.6_Missense_Mutation_p.T1014I|ANKRD17_ENST00000514252.1_5'UTR|ANKRD17_ENST00000509867.2_Missense_Mutation_p.T1152I	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	1265					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AACCACTTCAGTTCTTCCTTG	0.398000													18	73					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58740836	58740836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:58740836C>T	ENST00000305921.3	+	6	1973	c.1741C>T	c.(1741-1743)Cga>Tga	p.R581*		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	581					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			ACTCACCATGCGACGCAGACT	0.448000											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	10	59					0	0	1	0	0
DIAPH1	1729	broad.mit.edu	37	5	140905924	140905924	+	Silent	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:140905924G>A	ENST00000253811.6	-	25	3521	c.3381C>T	c.(3379-3381)ccC>ccT	p.P1127P	DIAPH1_ENST00000520569.1_Silent_p.P1069P|DIAPH1_ENST00000389057.5_Silent_p.P1117P|DIAPH1_ENST00000518047.1_Silent_p.P1114P|DIAPH1_ENST00000389054.3_Silent_p.P1123P|DIAPH1_ENST00000398557.4_Silent_p.P1126P|DIAPH1_ENST00000398562.2_Silent_p.P1102P|DIAPH1_ENST00000398566.3_Silent_p.P1118P			O60610	DIAP1_HUMAN	diaphanous-related formin 1	1126	FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACTTCTTGGGGTCAAAGA	0.428000													16	43					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15501415	15501415	+	Silent	SNP	A	A	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr6:15501415A>T	ENST00000341776.2	+	8	2467	c.2223A>T	c.(2221-2223)acA>acT	p.T741T	JARID2_ENST00000541660.1_Silent_p.T703T|JARID2_ENST00000397311.3_Silent_p.T569T	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	741					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AAGGCCACACAGAGAACGACC	0.642000													51	162					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30025364	30025364	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:30025364C>T	ENST00000346128.6	-	13	2144	c.1670G>A	c.(1669-1671)tGg>tAg	p.W557*	TJP1_ENST00000400011.2_Nonsense_Mutation_p.W561*|TJP1_ENST00000545208.2_Nonsense_Mutation_p.W557*|TJP1_ENST00000356107.6_Nonsense_Mutation_p.W557*	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	557	SH3.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AATAGCAAGCCAAGAGCCCAG	0.388000													10	54					0	0	1	0	0
DNASE2B	58511	broad.mit.edu	37	1	84876670	84876670	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:84876670T>C	ENST00000370665.3	+	4	568	c.535T>C	c.(535-537)Tat>Cat	p.Y179H	DNASE2B_ENST00000370662.3_5'UTR	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	179					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		GTACAACCAGTATGAGGCAAT	0.368000													6	13					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23927979	23927979	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr19:23927979C>A	ENST00000402377.3	-	4	514	c.373G>T	c.(373-375)Gga>Tga	p.G125*	ZNF681_ENST00000395385.3_Nonsense_Mutation_p.G56*	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTATAACCTCCTTTTTGCACT	0.294000													3	22					0.115264	0.11736	1	1	0
OR9G4	283189	broad.mit.edu	37	11	56510610	56510610	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:56510610A>C	ENST00000302957.3	-	1	677	c.678T>G	c.(676-678)atT>atG	p.I226M		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGATAGCAAGAATGCTGGAGA	0.488000													12	42					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187554873	187554873	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:187554873C>A	ENST00000441802.2	-	7	4497	c.4288G>T	c.(4288-4290)Gag>Tag	p.E1430*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1430	Cadherin 12.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCTGTAGCCTCGACTGTGAGG	0.463000										HNSCC(5;0.00058)			26	68					1.33986e-20	1.69565e-20	1	1	0
THNSL2	55258	broad.mit.edu	37	2	88482302	88482302	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:88482302A>G	ENST00000324166.5	+	5	2578	c.887A>G	c.(886-888)cAg>cGg	p.Q296R	THNSL2_ENST00000402102.1_Missense_Mutation_p.Q296R|THNSL2_ENST00000496844.1_3'UTR|THNSL2_ENST00000377254.3_Missense_Mutation_p.Q296R|THNSL2_ENST00000358591.2_Missense_Mutation_p.Q296R|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000343544.4_Missense_Mutation_p.Q296R	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	296					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						AGGACTGTCCAGCAGGGAGAC	0.537000													4	74					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66467959	66467959	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:66467959C>A	ENST00000273854.3	-	3	910	c.310G>T	c.(310-312)Gtg>Ttg	p.V104L	EPHA5_ENST00000432638.2_Missense_Mutation_p.V104L|EPHA5_ENST00000354839.4_Missense_Mutation_p.V104L|EPHA5_ENST00000511294.1_Missense_Mutation_p.V104L	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	104					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGTTCCATCACTTTGCATACT	0.378000										TSP Lung(17;0.13)			26	71					8.16721e-17	1.02778e-16	1	1	0
GOLGA8EP	390535	broad.mit.edu	37	15	23445456	23445456	+	RNA	SNP	G	G	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:23445456G>T	ENST00000526079.1	+	0	2276					NR_027407.1|NR_033350.1																						CAAGAAGAAGGAGATAAACAT	0.458000													18	109					3.5997e-14	4.45488e-14	1	1	0
NSUN2	54888	broad.mit.edu	37	5	6620375	6620375	+	Missense_Mutation	SNP	C	C	A	rs146332265		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:6620375C>A	ENST00000264670.6	-	7	970	c.659G>T	c.(658-660)cGc>cTc	p.R220L	NSUN2_ENST00000506139.1_Missense_Mutation_p.R185L|NSUN2_ENST00000539938.1_5'UTR|NSUN2_ENST00000505264.1_5'UTR	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	220						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						CAGGTAGCAGCGCTTGTTGTC	0.502000													27	80					3.65163e-15	4.56964e-15	1	1	0
ATP8B4	79895	broad.mit.edu	37	15	50331023	50331023	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:50331023G>A	ENST00000284509.6	-	6	445	c.304C>T	c.(304-306)Cgc>Tgc	p.R102C	ATP8B4_ENST00000559829.1_Missense_Mutation_p.R102C|ATP8B4_ENST00000558959.1_5'UTR	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	102					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTCTTGTGGCGAAACTGAAAA	0.363000													11	38					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	65					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	79952339	79952339	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:79952339C>T	ENST00000265081.6	+	2	427	c.347C>T	c.(346-348)tCt>tTt	p.S116F		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	116	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CTGGGAATGTCTGGCAACTCT	0.428000								Mismatch excision repair (MMR)					11	46					0	0	1	0	0
C1orf216	127703	broad.mit.edu	37	1	36181873	36181874	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:36181873_36181874insC	ENST00000270815.4	-	2	819_820	c.49_50insG	c.(49-51)cccfs	p.P17fs	C1orf216_ENST00000503824.1_5'UTR	NM_152374.1	NP_689587.1	Q8TAB5	CA216_HUMAN	chromosome 1 open reading frame 216	17								p.D17Y(1)		kidney(2)|lung(3)|skin(2)|urinary_tract(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				AGGAGGTGGGTCCCCCAGGAAT	0.574											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	31	---	---	---	---					
HFM1	164045	broad.mit.edu	37	1	91841183	91841183	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr1:91841183delG	ENST00000370425.3	-	12	1595	c.1497delC	c.(1495-1497)ccfs	p.P499fs	HFM1_ENST00000294696.5_5'UTR|HFM1_ENST00000370424.3_Frame_Shift_Del_p.P178fs	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	499							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TACTACTGCAGGGAAATCCAA	0.413													15	79	---	---	---	---					
CARF	79800	broad.mit.edu	37	2	203847093	203847106	+	Frame_Shift_Del	DEL	CTGTTCATCGGATT	CTGTTCATCGGATT	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:203847093_203847106delCTGTTCATCGGATT	ENST00000320443.8	+	15	3031_3044	c.1988_2001delCTGTTCATCGGATT	c.(1987-2001)afs	p.TVHRI663fs	CARF_ENST00000545253.1_Frame_Shift_Del_p.TVHRI575fs|CARF_ENST00000545262.1_Frame_Shift_Del_p.TVHRI587fs|WDR12_ENST00000477723.1_Intron|CARF_ENST00000414439.1_Frame_Shift_Del_p.TVHRI561fs|CARF_ENST00000438828.2_Frame_Shift_Del_p.TVHRI663fs|CARF_ENST00000402905.2_Frame_Shift_Del_p.TVHRI663fs|CARF_ENST00000428585.1_Frame_Shift_Del_p.TVHRI587fs					calcium responsive transcription factor																		CTGGAAGGAACTGTTCATCGGATTCTGTTGGGAG	0.407													9	48	---	---	---	---					
AC073321.4	0	broad.mit.edu	37	2	217475031	217475032	+	RNA	INS	-	-	AAA	rs71401156		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr2:217475031_217475032insAAA	ENST00000441803.1	+	0	195																											AATTTTATTTCAAAAAAAAAAA	0.376													6	7	---	---	---	---					
SH3BP5	9467	broad.mit.edu	37	3	15373833	15373835	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr3:15373833_15373835delTCC	ENST00000383791.3	-	1	301_303	c.81_83delGGA	c.(79-84)gaa>ga	p.EE27del	SH3BP5_ENST00000408919.3_Intron|SH3BP5_ENST00000253688.5_5'UTR|SH3BP5_ENST00000465894.2_Intron|SH3BP5_ENST00000426925.1_Intron	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	27	Glu-rich.				intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						catcccctcttcctcctcctcct	0.719													4	5	---	---	---	---					
LOC344967	344967	broad.mit.edu	37	4	40045668	40045668	+	RNA	DEL	C	C	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr4:40045668delC	ENST00000381811.2	-	0	481					NR_027277.1																						TCAGGATGGTCCCGCCTAGAC	0.612													2	4	---	---	---	---					
PCDHB12	56124	broad.mit.edu	37	5	140590332	140590332	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:140590332delG	ENST00000239450.2	+	1	2042	c.1853delG	c.(1852-1854)tgfs	p.W618fs	PCDHB12_ENST00000541609.1_Frame_Shift_Del_p.W281fs	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		618	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGGCGTGTGGGCGCACAAT	0.687													9	142	---	---	---	---					
PCDHGA8	9708	broad.mit.edu	37	5	140772972	140772972	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr5:140772972delC	ENST00000398604.2	+	1	592	c.592delC	c.(592-594)gcfs	p.R198fs	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCTGGAGCGCGCCCTGGA	0.632													19	46	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139397672	139397672	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr9:139397672delC	ENST00000277541.6	-	27	5204	c.5129delG	c.(5128-5130)gcfs	p.G1710fs		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1710					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTTGAGGCTGCCCAGCGAGGC	0.657			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			21	28	---	---	---	---					
RELA	5970	broad.mit.edu	37	11	65421910	65421911	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr11:65421910_65421911insC	ENST00000406246.3	-	11	1855_1856	c.1594_1595insG	c.(1594-1596)agafs	p.R532fs	RELA_ENST00000308639.9_Frame_Shift_Ins_p.R529fs|RELA_ENST00000525693.1_3'UTR	NM_001243984.1|NM_001243985.1|NM_021975.3	NP_001230913.1|NP_001230914.1|NP_068810.3	Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	532					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						GGAGAAGTCTTCATCTCCTGAA	0.639													7	54	---	---	---	---					
NCAPD2	9918	broad.mit.edu	37	12	6639104	6639104	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr12:6639104delG	ENST00000315579.5	+	29	4616	c.3817delG	c.(3817-3819)ggfs	p.G1273fs	NCAPD2_ENST00000545962.1_Frame_Shift_Del_p.G1228fs	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1273					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						GCTGCGACGTGGGGCCAAGCC	0.532													11	53	---	---	---	---					
CYSLTR2	57105	broad.mit.edu	37	13	49281365	49281366	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr13:49281365_49281366insT	ENST00000282018.3	+	1	415_416	c.412_413insT	c.(412-414)ggcfs	p.G138fs		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	138					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TGTGCGTTTCCTGGCAATGGTT	0.470													17	112	---	---	---	---					
OR4K17	390436	broad.mit.edu	37	14	20585576	20585577	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr14:20585576_20585577insC	ENST00000315543.4	+	1	11_12	c.11_12insC	c.(10-12)tttfs	p.F4fs		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ATGGCTCTTTATTTTTCACTCA	0.361													13	26	---	---	---	---					
STOML1	9399	broad.mit.edu	37	15	74281125	74281125	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr15:74281125delC	ENST00000316900.5	-	4	533	c.409delG	c.(409-411)ctfs	p.A137fs	STOML1_ENST00000561656.1_Frame_Shift_Del_p.A50fs|STOML1_ENST00000359750.4_Frame_Shift_Del_p.A137fs|STOML1_ENST00000316911.6_Frame_Shift_Del_p.A87fs|STOML1_ENST00000564777.1_Frame_Shift_Del_p.A87fs|STOML1_ENST00000541638.1_Frame_Shift_Del_p.A95fs	NM_001256672.1|NM_001256675.1|NM_001256677.1|NM_004809.4	NP_001243601.1|NP_001243604.1|NP_001243606.1|NP_004800.2	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	137						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						GACAGCACAGCCCCGTCCTTA	0.632													15	93	---	---	---	---					
RP11-51O6.1	0	broad.mit.edu	37	16	61089302	61089302	+	RNA	DEL	C	C	-	rs80101907		TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr16:61089302delC	ENST00000591758.1	-	0	566																											GCttcttcttctttttttttt	0.244													7	16	---	---	---	---					
DNAJB7	150353	broad.mit.edu	37	22	41257531	41257531	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chr22:41257531delT	ENST00000307221.4	-	1	599	c.468delA	c.(466-468)ggfs	p.G156fs	XPNPEP3_ENST00000482652.1_Intron|XPNPEP3_ENST00000357137.4_Intron|XPNPEP3_ENST00000414396.1_Intron|XPNPEP3_ENST00000541156.1_Intron	NM_145174.1	NP_660157.1	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	156					protein folding		heat shock protein binding|unfolded protein binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10						GTGATGTATATCCTGTATCAT	0.393													15	52	---	---	---	---					
USP9X	8239	broad.mit.edu	37	X	41073879	41073879	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D6-A6EK-01A-11D-A31L-08	TCGA-D6-A6EK-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c360fffa-f19a-4a7e-bce4-960421c65939	a028c0fd-8b5f-4788-905e-d90e3ab8e87b	g.chrX:41073879delC	ENST00000324545.7	+	34	5881	c.5248delC	c.(5248-5250)ttfs	p.L1751fs	USP9X_ENST00000378308.2_Frame_Shift_Del_p.L1751fs	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1751					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TCACCAAAATCTTCTTGATTC	0.333													17	19	---	---	---	---