Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GCG	2641	broad.mit.edu	37	2	163005678	163005678	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:163005678A>G	ENST00000418842.2	-	2	265	c.11T>C	c.(10-12)aTt>aCt	p.I4T	GCG_ENST00000375497.3_Missense_Mutation_p.I4T	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	4					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	CACAAAGTAAATGCTTTTCAT	0.433000													59	114					0	0	0.000781405	0	0
PCDHB5	26167	broad.mit.edu	37	5	140517214	140517214	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:140517214G>C	ENST00000231134.5	+	1	2415	c.2198G>C	c.(2197-2199)gGg>gCg	p.G733A		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		733					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTTTCCAGGGCATCTGGTG	0.652000													56	79					0	0	0.000781405	0	0
AGPAT9	84803	broad.mit.edu	37	4	84519214	84519214	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:84519214A>T	ENST00000395226.2	+	11	1225	c.1007A>T	c.(1006-1008)cAg>cTg	p.Q336L	AGPAT9_ENST00000264409.4_Missense_Mutation_p.Q336L	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	336					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				TATAACCCTCAGTTCGGTGAT	0.433000													16	53					0	0	0.000308642	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644856	20644856	+	RNA	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:20644856T>G	ENST00000428453.1	-	0	3091																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCTCGCCCTTTCGGTCTTGTC	0.448000													6	27					0	0	0.000274275	0	0
GPALPP1	55425	broad.mit.edu	37	13	45580367	45580367	+	Silent	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr13:45580367T>C	ENST00000361121.2	+	3	287	c.252T>C	c.(250-252)gaT>gaC	p.D84D	KIAA1704_ENST00000379151.4_Silent_p.D84D|KIAA1704_ENST00000357537.3_5'UTR|RP11-321C24.1_ENST00000437748.2_lincRNA			Q8IXQ4	K1704_HUMAN		84	Poly-Asp.									breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|prostate(2)|skin(1)	12		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		atgatgacgatgatgatgatg	0.338000													4	175					0	0	0.000602214	0	0
POM121	9883	broad.mit.edu	37	7	72413896	72413896	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:72413896A>G	ENST00000395270.1	+	14	3610	c.2569A>G	c.(2569-2571)Acc>Gcc	p.T857A	POM121_ENST00000434423.2_Missense_Mutation_p.T1122A|POM121_ENST00000358357.3_Missense_Mutation_p.T857A|POM121_ENST00000446813.1_Missense_Mutation_p.T857A|POM121_ENST00000257622.4_Missense_Mutation_p.T857A	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1122	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore		p.T857A(8)		NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				AGGCTCCAGCACCACCACCGG	0.637000													3	24					0	0	6.4e-05	0	0
USP35	57558	broad.mit.edu	37	11	77924730	77924730	+	Silent	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:77924730C>A	ENST00000529308.1	+	11	3189	c.2928C>A	c.(2926-2928)atC>atA	p.I976I	USP35_ENST00000526425.1_Silent_p.I707I|USP35_ENST00000441408.2_Silent_p.I562I|USP35_ENST00000530267.1_Silent_p.I544I|USP35_ENST00000530535.1_3'UTR	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	976					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CGGCCTACATCTCTGCACTCC	0.577000													19	53					4.96729e-08	2.80461e-07	0.00121646	1	0
RBM6	10180	broad.mit.edu	37	3	50095370	50095370	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:50095370A>T	ENST00000443081.1	+	9	2426	c.1507A>T	c.(1507-1509)Act>Tct	p.T503S	RBM6_ENST00000442092.1_Missense_Mutation_p.T113S|RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000266022.4_Missense_Mutation_p.T635S|RBM6_ENST00000422955.1_Missense_Mutation_p.T113S|RBM6_ENST00000539992.1_5'UTR			P78332	RBM6_HUMAN	RNA binding motif protein 6	635	RRM.				RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GGAAGGGCCAACTTTCCGAAG	0.517000													6	10					0	0	0.00198382	0	0
AXDND1	126859	broad.mit.edu	37	1	179401427	179401427	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:179401427A>C	ENST00000367618.3	+	15	1900	c.1513A>C	c.(1513-1515)Aag>Cag	p.K505Q	AXDND1_ENST00000457238.2_Missense_Mutation_p.K505Q|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	505										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						ATCCCCTAATAAGGGAAATAT	0.308000													4	11					0	0	0.000602214	0	0
FOXP1	27086	broad.mit.edu	37	3	71026794	71026794	+	Splice_Site	SNP	C	C	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:71026794C>G	ENST00000318789.4	-	16	1953	c.1428_splice	c.e16+1	p.Q476_splice	FOXP1_ENST00000475937.1_Splice_Site_p.Q476_splice|FOXP1_ENST00000484350.1_Splice_Site_p.Q400_splice|FOXP1_ENST00000498215.1_Splice_Site_p.Q476_splice|FOXP1_ENST00000491238.1_Splice_Site_p.Q478_splice|FOXP1_ENST00000493089.1_Splice_Site_p.Q475_splice|FOXP1_ENST00000468577.1_Splice_Site_p.Q476_splice	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	476					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		ATTTACTTACCTGCCTAATTA	0.323000			T	PAX5	ALL								10	48					0	0	0.000978159	0	0
TRBV6-6	28601	broad.mit.edu	37	7	142161982	142161982	+	RNA	SNP	T	T	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:142161982T>A	ENST00000390371.3	-	0	336																											AGCAGCCAACTCCAGCCTGAG	0.502000													56	226					0	0	0.000781405	0	0
SLC36A4	120103	broad.mit.edu	37	11	92901243	92901243	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:92901243T>C	ENST00000326402.4	-	7	765	c.635A>G	c.(634-636)tAt>tGt	p.Y212C	SLC36A4_ENST00000529184.1_Missense_Mutation_p.Y77C	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	212					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCAAAGCATATATATCCTTAG	0.353000													19	47					0	0	0.000958276	0	0
BRCA1	672	broad.mit.edu	37	17	41256883	41256883	+	Splice_Site	SNP	A	A	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:41256883A>C	ENST00000309486.4	-	4	441		c.e4+1		BRCA1_ENST00000468300.1_Splice_Site|BRCA1_ENST00000493795.1_Splice_Site|BRCA1_ENST00000357654.3_Splice_Site|BRCA1_ENST00000354071.3_Splice_Site|BRCA1_ENST00000351666.3_Splice_Site|BRCA1_ENST00000346315.3_Splice_Site|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000491747.2_Splice_Site|BRCA1_ENST00000471181.2_Splice_Site|BRCA1_ENST00000352993.3_Splice_Site	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset						androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTCAACACTTACACTCCAAAC	0.373000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			28	47					0	0	0.00178596	0	0
FRMD3	257019	broad.mit.edu	37	9	85863354	85863354	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr9:85863354C>G	ENST00000304195.3	-	14	1479	c.1273G>C	c.(1273-1275)Gaa>Caa	p.E425Q	FRMD3_ENST00000465485.1_5'UTR|FRMD3_ENST00000328788.1_Missense_Mutation_p.E82Q|FRMD3_ENST00000376438.1_Missense_Mutation_p.E425Q|FRMD3_ENST00000376434.1_Missense_Mutation_p.E231Q	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	425						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						GGGGGATCTTCATACTCCCGG	0.468000													12	37					0	0	0.000978159	0	0
GALNT8	26290	broad.mit.edu	37	12	4854675	4854675	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:4854675C>T	ENST00000252318.2	+	5	1278	c.941C>T	c.(940-942)aCc>aTc	p.T314I		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	314						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CGTTTTGACACCTTCAAACTG	0.488000													23	69					0	0	0.00047179	0	0
NTRK3	4916	broad.mit.edu	37	15	88678559	88678559	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:88678559C>A	ENST00000394480.1	-	10	1298	c.977G>T	c.(976-978)cGt>cTt	p.R326L	NTRK3_ENST00000355254.2_Missense_Mutation_p.R326L|NTRK3_ENST00000557856.1_Missense_Mutation_p.R326L|NTRK3_ENST00000357724.2_Missense_Mutation_p.R326L|NTRK3_ENST00000542733.2_Missense_Mutation_p.R228L|NTRK3_ENST00000317501.3_Missense_Mutation_p.R326L|NTRK3_ENST00000360948.2_Missense_Mutation_p.R326L|NTRK3_ENST00000540489.2_Missense_Mutation_p.R326L|NTRK3_ENST00000558676.1_Missense_Mutation_p.R326L	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	326	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGGTTGCCACGCACCACAAA	0.592000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			22	38					5.26018e-13	3.139e-12	0.00188189	1	0
ZNF556	80032	broad.mit.edu	37	19	2877900	2877900	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:2877900A>G	ENST00000586426.1	+	4	1028	c.941A>G	c.(940-942)tAt>tGt	p.Y314C	ZNF556_ENST00000307635.2_Missense_Mutation_p.Y315C			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGAAACCCTATAAGTGTGGA	0.527000													6	36					0	0	0.00198382	0	0
UBTF	7343	broad.mit.edu	37	17	42284865	42284865	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:42284865G>A	ENST00000302904.4	-	20	2618	c.2126C>T	c.(2125-2127)tCc>tTc	p.S709F	UBTF_ENST00000526094.1_Missense_Mutation_p.S672F|UBTF_ENST00000436088.1_Missense_Mutation_p.S709F|UBTF_ENST00000393606.3_Missense_Mutation_p.S672F|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000529383.1_Missense_Mutation_p.S709F|UBTF_ENST00000533177.1_Missense_Mutation_p.S672F|UBTF_ENST00000527034.1_Missense_Mutation_p.P671S|UBTF_ENST00000343638.5_Missense_Mutation_p.S672F			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	709	Asp/Glu/Ser-rich (acidic).				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGACTCAGAGGAGTCGCCGCC	0.607000													17	27					0	0	0.000958276	0	0
TTYH2	94015	broad.mit.edu	37	17	72246094	72246094	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:72246094G>A	ENST00000269346.4	+	9	1024	c.950G>A	c.(949-951)cGc>cAc	p.R317H	TTYH2_ENST00000534346.1_3'UTR|TTYH2_ENST00000441391.2_5'UTR|TTYH2_ENST00000529107.1_Missense_Mutation_p.R296H	NM_032646.5	NP_116035.5	Q9BSA4	TTYH2_HUMAN	tweety family member 2	317						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						ACCTTCCAGCGCGCACTTACC	0.642000													21	83					0	0	0.00047179	0	0
RGS7	6000	broad.mit.edu	37	1	240939491	240939491	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:240939491C>T	ENST00000366565.1	-	18	1817	c.1436G>A	c.(1435-1437)aGg>aAg	p.R479K	RGS7_ENST00000366562.4_Missense_Mutation_p.R461K|RGS7_ENST00000348120.2_3'UTR|RGS7_ENST00000366564.1_Missense_Mutation_p.R461K|RGS7_ENST00000366563.1_3'UTR|RGS7_ENST00000331110.7_Intron|RGS7_ENST00000446183.2_3'UTR	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	0					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GCTTGTTAACCTCTTGGACGT	0.403000													4	55					0	0	0.00024832	0	0
FXR2	9513	broad.mit.edu	37	17	7497597	7497597	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:7497597G>A	ENST00000250113.7	-	10	1313	c.979C>T	c.(979-981)Cga>Tga	p.R327*		NM_004860.3	NP_004851.2	P51116	FXR2_HUMAN	fragile X mental retardation, autosomal homolog 2	327						cytosolic large ribosomal subunit	protein binding|RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)	26				READ - Rectum adenocarcinoma(115;0.17)		CCTTCCACTCGAACCCTCACC	0.468000													6	24					0	0	0.000157383	0	0
TRHR	7201	broad.mit.edu	37	8	110131311	110131311	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:110131311T>G	ENST00000518632.1	+	3	1175	c.824T>G	c.(823-825)tTt>tGt	p.F275C	TRHR_ENST00000311762.2_Missense_Mutation_p.F275C			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	275						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GTAATTCTGTTTGCCCTTTTA	0.408000													38	375					0	0	0.00170553	0	0
RP1	6101	broad.mit.edu	37	8	55539875	55539875	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:55539875T>C	ENST00000220676.1	+	4	3581	c.3433T>C	c.(3433-3435)Ttc>Ctc	p.F1145L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1145					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATGAATAGCTTCTGTCAAGT	0.408000													4	84					0	0	0.00024832	0	0
PRB2	653247	broad.mit.edu	37	12	11546653	11546653	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:11546653C>A	ENST00000389362.4	-	3	394	c.359G>T	c.(358-360)gGa>gTa	p.G120V	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGGGGTGGTCCTTGTGGCTT	0.597000													32	713					6.90743e-12	4.05604e-11	0.000692331	1	0
MRPS35	60488	broad.mit.edu	37	12	27888432	27888432	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:27888432A>C	ENST00000081029.3	+	6	646	c.575A>C	c.(574-576)aAa>aCa	p.K192T	MRPS35_ENST00000538315.1_Intron	NM_021821.3	NP_068593.2	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35	192					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				breast(1)|endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	6	Lung SC(9;0.0873)					AAATTAATTAAACTTGTAGGA	0.323000													22	54					0	0	0.000720815	0	0
ARPC2	10109	broad.mit.edu	37	2	219099116	219099116	+	Silent	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:219099116A>G	ENST00000295685.10	+	4	525	c.264A>G	c.(262-264)gaA>gaG	p.E88E	ARPC2_ENST00000315717.5_Silent_p.E88E	NM_005731.2	NP_005722.1	O15144	ARPC2_HUMAN	actin related protein 2/3 complex, subunit 2, 34kDa	88					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	6		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		TAAATCCAGAATCAGGTATGT	0.328000													19	45					0	0	0.00188189	0	0
TNIP3	79931	broad.mit.edu	37	4	122063056	122063056	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:122063056G>T	ENST00000454328.1	-	11	1027	c.800C>A	c.(799-801)cCc>cAc	p.P267H	TNIP3_ENST00000509841.1_Missense_Mutation_p.P344H|TNIP3_ENST00000507879.1_Missense_Mutation_p.P337H|TNIP3_ENST00000511909.1_5'UTR|TNIP3_ENST00000057513.3_Missense_Mutation_p.P267H			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	267										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						GCAGTTACAGGGTGGGCAATA	0.507000													7	40					7.48243e-07	4.1294e-06	0.000442599	1	0
JAKMIP2	9832	broad.mit.edu	37	5	147040903	147040903	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:147040903C>T	ENST00000265272.5	-	3	702	c.235G>A	c.(235-237)Gag>Aag	p.E79K	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.E79K|JAKMIP2_ENST00000333010.6_Missense_Mutation_p.E37K	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	79						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTTCTCCTCATGGAGCTTG	0.517000													64	65					0	0	0.000781405	0	0
CTNNA2	1496	broad.mit.edu	37	2	80782950	80782950	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:80782950T>C	ENST00000466387.1	+	16	2397	c.1673T>C	c.(1672-1674)aTg>aCg	p.M558T	CTNNA2_ENST00000541047.1_Missense_Mutation_p.M558T|CTNNA2_ENST00000540488.1_Missense_Mutation_p.M558T|CTNNA2_ENST00000361291.4_Missense_Mutation_p.M592T|CTNNA2_ENST00000343114.3_Missense_Mutation_p.M237T|CTNNA2_ENST00000402739.4_Missense_Mutation_p.M558T|CTNNA2_ENST00000496558.1_Missense_Mutation_p.M558T			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	558					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AATGCTGAGATGGAGAACTAT	0.512000													10	79					0	0	0.000673444	0	0
CDH26	60437	broad.mit.edu	37	20	58560126	58560126	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr20:58560126C>T	ENST00000348616.4	+	7	1079	c.779C>T	c.(778-780)aCc>aTc	p.T260I	CDH26_ENST00000244047.5_Missense_Mutation_p.T260I	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	260	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TCCACGACCACCGTTCACGTG	0.547000													8	42					0	0	0.000157383	0	0
MBOAT7	79143	broad.mit.edu	37	19	54692110	54692110	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:54692110G>T	ENST00000245615.1	-	3	647	c.167C>A	c.(166-168)aCc>aAc	p.T56N	MBOAT7_ENST00000391754.1_Missense_Mutation_p.T56N|MBOAT7_ENST00000431666.2_Missense_Mutation_p.H25Q|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000338624.6_Missense_Mutation_p.H25Q	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	56					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCGAGGATGGTGACCAGAGA	0.642000													21	37					8.04996e-18	4.84317e-17	0.00188189	1	0
SIM1	6492	broad.mit.edu	37	6	100838366	100838366	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:100838366G>T	ENST00000369208.3	-	12	2954	c.2172C>A	c.(2170-2172)agC>agA	p.S724R	SIM1_ENST00000262901.4_Missense_Mutation_p.S724R			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	724	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TAATGGTTTCGCTGTCATATA	0.463000													17	83					0.000566183	0.00301144	0.000566183	1	0
ZNF572	137209	broad.mit.edu	37	8	125989980	125989980	+	Silent	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:125989980C>T	ENST00000319286.5	+	3	1624	c.1470C>T	c.(1468-1470)caC>caT	p.H490H		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GGAAAATTCACGTAGAAAAGC	0.473000										HNSCC(60;0.17)			18	183					0	0	0.00074312	0	0
OR51A4	401666	broad.mit.edu	37	11	4967421	4967421	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:4967421C>T	ENST00000380373.2	-	1	935	c.910G>A	c.(910-912)Gtt>Att	p.V304I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTTGCTACAACTCTCACTCTA	0.353000													28	254					0	0	0.00106085	0	0
NAV2	89797	broad.mit.edu	37	11	19735323	19735323	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:19735323C>T	ENST00000396085.1	+	1	443	c.82C>T	c.(82-84)Ccc>Tcc	p.P28S	NAV2_ENST00000360655.4_Intron|NAV2_ENST00000349880.4_Missense_Mutation_p.P28S|NAV2_ENST00000396087.3_Missense_Mutation_p.P28S	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	28						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CCTGCACGTgcccccggcccg	0.662000													7	25					0	0	0.00198382	0	0
DGKD	8527	broad.mit.edu	37	2	234346041	234346041	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:234346041G>T	ENST00000264057.2	+	8	850	c.838G>T	c.(838-840)Gaa>Taa	p.E280*	DGKD_ENST00000409813.3_Nonsense_Mutation_p.E236*	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	280					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	ATCGTGTAAAGAATCCTTGCT	0.542000													11	22					0.000978159	0.00512835	0.000978159	1	0
PHF3	23469	broad.mit.edu	37	6	64422440	64422440	+	Silent	SNP	T	T	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:64422440T>A	ENST00000262043.3	+	16	5296	c.4956T>A	c.(4954-4956)ccT>ccA	p.P1652P	PHF3_ENST00000393387.1_Silent_p.P1652P			Q92576	PHF3_HUMAN	PHD finger protein 3	1652					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAGGGATCCTAGGCAAGCAG	0.453000													10	27					0	0	0.000673444	0	0
SPI1	6688	broad.mit.edu	37	11	47381575	47381575	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:47381575G>C	ENST00000378538.3	-	3	381	c.159C>G	c.(157-159)ttC>ttG	p.F53L	SPI1_ENST00000227163.4_Missense_Mutation_p.F54L|SPI1_ENST00000533030.1_Intron|SPI1_ENST00000533968.1_Missense_Mutation_p.F53L	NM_001080547.1|NM_003120.2	NP_001074016.1|NP_003111.2	P17947	SPI1_HUMAN	spleen focus forming virus (SFFV) proviral integration oncogene	53					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(4)|ovary(1)	8				Lung(87;0.0967)		GGTGGGGGTGGAAGTCCCAGT	0.582000													6	6					0	0	0.00198382	0	0
LPPR4	9890	broad.mit.edu	37	1	99771647	99771647	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:99771647G>A	ENST00000370185.3	+	7	1870	c.1373G>A	c.(1372-1374)cGa>cAa	p.R458Q	LPPR4_ENST00000457765.1_Missense_Mutation_p.R400Q|LPPR4_ENST00000370184.1_Missense_Mutation_p.R300Q	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		458							phosphatidate phosphatase activity	p.R458Q(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AATGAAAGTCGAAAGTTGTCC	0.493000													27	67					0	0	0.000878237	0	0
LDLRAD4	753	broad.mit.edu	37	18	13621135	13621135	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr18:13621135A>C	ENST00000361205.4	+	5	869	c.201A>C	c.(199-201)caA>caC	p.Q67H	LDLRAD4_ENST00000586765.1_Missense_Mutation_p.Q30H|LDLRAD4_ENST00000399848.3_Missense_Mutation_p.Q67H|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.Q67H|LDLRAD4_ENST00000587757.1_Missense_Mutation_p.Q30H|LDLRAD4_ENST00000585931.1_5'UTR	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		AGTTCGCCCAAATCATCATCA	0.602000													47	95					0	0	0.000781405	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													4	54					0	0	0.000602214	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973844	29973844	+	Silent	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chrX:29973844G>A	ENST00000378993.1	+	11	2671	c.1998G>A	c.(1996-1998)tcG>tcA	p.S666S	IL1RAPL1_ENST00000302196.4_Silent_p.S666S	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	666					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AGACAAAATCGAGCAGGGAGC	0.527000													7	7					0	0	0.00198382	0	0
CSMD3	114788	broad.mit.edu	37	8	113842012	113842012	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:113842012G>T	ENST00000297405.5	-	12	2006	c.1762C>A	c.(1762-1764)Cag>Aag	p.Q588K	CSMD3_ENST00000455883.2_Missense_Mutation_p.Q484K|CSMD3_ENST00000343508.3_Missense_Mutation_p.Q548K|CSMD3_ENST00000352409.3_Missense_Mutation_p.Q588K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	588	CUB 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAATTTATCTGGATAACCTAG	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	29					0.000602214	0.00318004	0.000602214	1	0
NCOR2	9612	broad.mit.edu	37	12	124979778	124979778	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:124979778G>A	ENST00000356219.3	-	2	175	c.20C>T	c.(19-21)cCt>cTt	p.P7L	NCOR2_ENST00000429285.2_Missense_Mutation_p.P7L|NCOR2_ENST00000405201.1_Missense_Mutation_p.P7L|NCOR2_ENST00000404621.1_Missense_Mutation_p.P7L|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000397355.1_Missense_Mutation_p.P7L	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	7				P -> L (in Ref. 2; AAD20946).	cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTGTGCCACAGGCTGTGTGGA	0.627000													5	29					0	0	0.000602214	0	0
SF3B2	10992	broad.mit.edu	37	11	65826722	65826722	+	Silent	SNP	C	C	T	rs71762974		TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:65826722C>T	ENST00000528302.1	+	10	1236	c.1182C>T	c.(1180-1182)gaC>gaT	p.D394D	SF3B2_ENST00000322535.6_Silent_p.D411D			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	411					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						AGAAACTTGACAAACTGGAGA	0.532000													10	27					0	0	0.000442599	0	0
PRDM15	63977	broad.mit.edu	37	21	43279700	43279700	+	Splice_Site	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr21:43279700C>A	ENST00000422911.1	-	3	344		c.e3+1		PRDM15_ENST00000447207.2_Splice_Site|PRDM15_ENST00000538201.1_Splice_Site|PRDM15_ENST00000269844.3_Splice_Site|PRDM15_ENST00000398548.1_Splice_Site			P57071	PRD15_HUMAN	PR domain containing 15						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CGGTCACTCACCTTGCCCTGC	0.612000													10	12					3.86212e-05	0.000208441	0.000673444	1	0
TFIP11	24144	broad.mit.edu	37	22	26902303	26902303	+	Silent	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr22:26902303G>A	ENST00000407690.1	-	6	769	c.486C>T	c.(484-486)taC>taT	p.Y162Y	TFIP11_ENST00000407431.1_Silent_p.Y162Y|TFIP11_ENST00000407148.1_Silent_p.Y162Y|TFIP11_ENST00000405938.1_Silent_p.Y162Y	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	162	G-patch.				biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						GTCCAGGGACGTAGCCCATCT	0.527000													14	86					0	0	0.00185496	0	0
KRT4	3851	broad.mit.edu	37	12	53201426	53201426	+	Splice_Site	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:53201426A>G	ENST00000293774.4	-	7	1839		c.e7+1		KRT4_ENST00000458244.2_Splice_Site|KRT4_ENST00000551956.1_Splice_Site			B4DRS2	B4DRS2_HUMAN	keratin 4							keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CTAACCCCTCACCTGTACTCC	0.582000													31	57					0	0	0.00178596	0	0
FBLN1	2192	broad.mit.edu	37	22	45944530	45944530	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr22:45944530C>G	ENST00000348697.2	+	13	1626	c.1479C>G	c.(1477-1479)atC>atG	p.I493M	FBLN1_ENST00000476366.1_Intron|FBLN1_ENST00000442170.2_Missense_Mutation_p.I493M|FBLN1_ENST00000340923.5_Missense_Mutation_p.I493M|FBLN1_ENST00000402984.3_Missense_Mutation_p.I531M|FBLN1_ENST00000327858.6_Missense_Mutation_p.I493M|FBLN1_ENST00000262722.7_Missense_Mutation_p.I493M			P23142	FBLN1_HUMAN	fibulin 1	493	EGF-like 8; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GGGGCCACATCTGCTCCTACC	0.652000													13	38					0	0	0.00185496	0	0
GCNT2	2651	broad.mit.edu	37	6	10586756	10586756	+	Silent	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:10586756C>T	ENST00000265012.4	+	1	778	c.534C>T	c.(532-534)gtC>gtT	p.V178V	GCNT2_ENST00000316170.3_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000495262.1_Intron	NM_145655.3	NP_663630.2	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	178						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AAGACCTTGTCGCCTCTGAGG	0.473000													48	102					0	0	0.000781405	0	0
JRKL	8690	broad.mit.edu	37	11	96125222	96125222	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:96125222T>G	ENST00000458427.1	+	1	2065	c.1409T>G	c.(1408-1410)cTa>cGa	p.L470R	JRKL_ENST00000546177.1_Intron|JRKL_ENST00000332349.4_Missense_Mutation_p.L470R	NM_003772.3	NP_003763.2	Q9Y4A0	JERKL_HUMAN	jerky homolog-like (mouse)	470					central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		GAAATAGAACTAATTCCAGAG	0.398000													5	22					0	0	0.00116845	0	0
TLE2	7089	broad.mit.edu	37	19	3002388	3002388	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:3002388G>C	ENST00000262953.6	-	18	2272	c.2010C>G	c.(2008-2010)caC>caG	p.H670Q	TLE2_ENST00000455444.2_Missense_Mutation_p.H548Q|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000426948.2_Missense_Mutation_p.H684Q|TLE2_ENST00000447365.2_Missense_Mutation_p.H337Q|TLE2_ENST00000443826.3_Missense_Mutation_p.H548Q|TLE2_ENST00000590536.1_Missense_Mutation_p.H671Q|TLE2_ENST00000591529.1_Missense_Mutation_p.H684Q	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	670					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAGCTCTCGTGGAGGTGCA	0.612000													7	27					0	0	0.000157383	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47076479	47076479	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:47076479G>C	ENST00000290341.3	+	2	518	c.184G>C	c.(184-186)Gaa>Caa	p.E62Q	IGF2BP1_ENST00000515586.1_3'UTR|IGF2BP1_ENST00000431824.2_Missense_Mutation_p.E62Q	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	62	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGGGAAAGTAGAATTACAAGG	0.468000													6	28					0	0	0.00198382	0	0
ACTR6	64431	broad.mit.edu	37	12	100604114	100604114	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:100604114A>T	ENST00000188312.2	+	6	1322	c.557A>T	c.(556-558)gAg>gTg	p.E186V	ACTR6_ENST00000546902.1_Missense_Mutation_p.E104V|ACTR6_ENST00000552376.1_Missense_Mutation_p.E186V|ACTR6_ENST00000551617.1_Missense_Mutation_p.E104V	NM_022496.4	NP_071941.1	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog (yeast)	186						cytoplasm|cytoskeleton				autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14						CATCTAAAGGAGATCATATCT	0.358000													33	75					0	0	0.0024448	0	0
ZNF567	163081	broad.mit.edu	37	19	37210259	37210259	+	Silent	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:37210259A>G	ENST00000585696.1	+	3	1770	c.540A>G	c.(538-540)ggA>ggG	p.G180G	ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000392163.2_Silent_p.G180G|ZNF567_ENST00000360729.4_Silent_p.G180G|ZNF567_ENST00000536254.2_Silent_p.G211G|ZNF567_ENST00000588311.1_Silent_p.G180G			Q8N184	ZN567_HUMAN	zinc finger protein 567	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGTCATTTGGATATAATGACT	0.368000													16	29					0	0	0.000566183	0	0
EHF	26298	broad.mit.edu	37	11	34673089	34673089	+	Splice_Site	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:34673089A>T	ENST00000257831.3	+	5	528	c.406_splice	c.e5-1	p.E136_splice	EHF_ENST00000530286.1_Splice_Site_p.E136_splice|EHF_ENST00000450654.2_Splice_Site_p.E136_splice|EHF_ENST00000533754.1_Splice_Site_p.E136_splice|EHF_ENST00000531794.1_Splice_Site_p.E158_splice	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	136					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTTTTTGTAGAGCCTTCCATC	0.423000													20	41					0	0	0.00152264	0	0
UNC5C	8633	broad.mit.edu	37	4	96222757	96222757	+	Splice_Site	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:96222757A>T	ENST00000453304.1	-	3	838	c.490_splice	c.e3+1	p.Y164_splice	UNC5C_ENST00000506749.1_Splice_Site_p.Y164_splice|UNC5C_ENST00000504962.1_Splice_Site_p.Y164_splice	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	164	Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AATGACTCACATGCAATGCGC	0.483000													13	60					0	0	0.00244969	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166514	19166514	+	Missense_Mutation	SNP	G	G	A	rs149445409		TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:19166514G>A	ENST00000375371.3	-	6	2120	c.2099C>T	c.(2098-2100)aCg>aTg	p.T700M		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	700					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	ACTGAGGCCCGTGGCCAGCAT	0.562000													40	77					0	0	0.00128727	0	0
CDH3	1001	broad.mit.edu	37	16	68732227	68732227	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:68732227A>G	ENST00000264012.4	+	16	2958	c.2414A>G	c.(2413-2415)gAt>gGt	p.D805G	CDH3_ENST00000429102.2_3'UTR|CDH3_ENST00000581171.1_Missense_Mutation_p.D750G	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	805					adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CAAGACCAAGATTACGATTAT	0.642000													34	112					0	0	0.000814825	0	0
FAT3	120114	broad.mit.edu	37	11	92085482	92085482	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:92085482G>A	ENST00000298047.6	+	1	221	c.204G>A	c.(202-204)atG>atA	p.M68I	FAT3_ENST00000409404.2_Missense_Mutation_p.M68I|FAT3_ENST00000541502.1_Missense_Mutation_p.M68I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	68	Cadherin 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGAGTAGAATGGGCATCACCT	0.458000										TCGA Ovarian(4;0.039)			16	48					0	0	0.000566183	0	0
CCR8	1237	broad.mit.edu	37	3	39374725	39374725	+	Silent	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:39374725T>G	ENST00000326306.4	+	2	1041	c.903T>G	c.(901-903)gcT>gcG	p.A301A	CCR8_ENST00000545843.1_Silent_p.A218A|CCR8_ENST00000414803.1_3'UTR	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	301					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TTATCTATGCTTTTGTTGGGG	0.423000													20	27					0	0	0.00152264	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768590	31768590	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr21:31768590G>T	ENST00000355459.2	+	1	199	c.186G>T	c.(184-186)gaG>gaT	p.E62D		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	62	5 X 10 AA approximate repeats.					intermediate filament		p.E62D(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTGCTGGGAGCCCACCAGCT	0.612000													19	43					1.33834e-09	7.61503e-09	0.000958276	1	0
ROPN1L	83853	broad.mit.edu	37	5	10448390	10448390	+	Silent	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:10448390G>A	ENST00000503804.1	+	3	671	c.150G>A	c.(148-150)tcG>tcA	p.S50S	ROPN1L_ENST00000510520.1_3'UTR|ROPN1L_ENST00000274134.4_Silent_p.S50S			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	50					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding	p.S50S(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						CAGCTCTGTCGAGAGGAGATC	0.423000													24	48					0	0	0.000586117	0	0
CHERP	10523	broad.mit.edu	37	19	16638963	16638963	+	Silent	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:16638963G>A	ENST00000546361.2	-	9	1384	c.1233C>T	c.(1231-1233)caC>caT	p.H411H	CHERP_ENST00000198939.6_Silent_p.H422H|CTD-3222D19.2_ENST00000409035.1_Intron	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	411	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						GGATCTGGTCGTGTggcccgg	0.647000													27	71					0	0	0.000878237	0	0
CDC14A	8556	broad.mit.edu	37	1	100819350	100819350	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:100819350C>A	ENST00000370125.2	+	2	570	c.82C>A	c.(82-84)Cca>Aca	p.P28T	CDC14A_ENST00000370124.3_Missense_Mutation_p.P28T|CDC14A_ENST00000361544.6_Missense_Mutation_p.P28T|CDC14A_ENST00000336454.3_Missense_Mutation_p.P28T|CDC14A_ENST00000544534.1_Missense_Mutation_p.P28T|CDC14A_ENST00000542213.1_5'UTR			Q9UNH5	CC14A_HUMAN	cell division cycle 14A	28	A.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		AAGGAATAGACCAAAAAGCAC	0.358000													7	23					0.000274275	0.00146947	0.000274275	1	0
SNX33	257364	broad.mit.edu	37	15	75941779	75941779	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:75941779T>G	ENST00000308527.5	+	1	1533	c.336T>G	c.(334-336)gaT>gaG	p.D112E		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	112	Poly-Asp.				cell communication		phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						TTGAGGAGGATGATGATGATG	0.622000													3	100					0	0	6.4e-05	0	0
INPPL1	3636	broad.mit.edu	37	11	71939892	71939892	+	Splice_Site	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:71939892G>A	ENST00000298229.2	+	4	722		c.e4+1		INPPL1_ENST00000538751.1_Splice_Site|INPPL1_ENST00000541756.1_Splice_Site	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1						actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CTGCTGAGAGGTGAGACCCCC	0.627000													21	44					0	0	0.00121646	0	0
OR52M1	119772	broad.mit.edu	37	11	4566851	4566851	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:4566851G>A	ENST00000360213.1	+	1	431	c.431G>A	c.(430-432)gGt>gAt	p.G144D		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAGTGGTGGGTCGTTTGGGG	0.522000													28	60					0	0	0.00106085	0	0
FAM98B	283742	broad.mit.edu	37	15	38773633	38773633	+	Silent	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:38773633G>A	ENST00000397609.2	+	7	905	c.870G>A	c.(868-870)cgG>cgA	p.R290R	FAM98B_ENST00000491535.1_Silent_p.R290R	NM_173611.2	NP_775882.2	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	290						tRNA-splicing ligase complex	protein binding			endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		GCACCAGCCGGGAGAAGACCG	0.398000													11	48					0	0	0.000978159	0	0
FBN1	2200	broad.mit.edu	37	15	48784730	48784730	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:48784730T>G	ENST00000316623.5	-	24	3237	c.2782A>C	c.(2782-2784)Aac>Cac	p.N928H		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	928	EGF-like 14; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCCCTAGTGTTAACACACAGG	0.348000													8	36					0	0	0.000442599	0	0
DISC1	27185	broad.mit.edu	37	1	231830106	231830106	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:231830106G>T	ENST00000439617.2	+	2	655	c.602G>T	c.(601-603)gGc>gTc	p.G201V	DISC1_ENST00000602873.1_Intron|DISC1_ENST00000535983.1_Missense_Mutation_p.G201V|DISC1_ENST00000366637.3_5'UTR|DISC1_ENST00000602281.1_Missense_Mutation_p.G201V|DISC1_ENST00000539444.1_Missense_Mutation_p.G201V|DISC1_ENST00000366636.4_Missense_Mutation_p.G201V|DISC1_ENST00000317586.4_Missense_Mutation_p.G201V|DISC1_ENST00000366633.3_Missense_Mutation_p.G201V|DISC1_ENST00000537876.1_Missense_Mutation_p.G201V|TRAX_ENST00000602962.1_3'UTR	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	201	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				ACCCCTCCTGGCTCTCACAGT	0.612000													9	66					7.48243e-07	4.1294e-06	0.000442599	1	0
C6orf10	10665	broad.mit.edu	37	6	32337718	32337718	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:32337718A>C	ENST00000375015.4	-	2	256	c.56T>G	c.(55-57)aTc>aGc	p.I19S	C6orf10_ENST00000447241.2_Missense_Mutation_p.I19S|C6orf10_ENST00000527965.1_Missense_Mutation_p.I19S|C6orf10_ENST00000375007.4_Missense_Mutation_p.I19S|C6orf10_ENST00000442822.2_Missense_Mutation_p.I19S|C6orf10_ENST00000533191.1_Missense_Mutation_p.I19S			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	19						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						AATAGCCAGGATGGCAAGTCC	0.403000													64	102					0	0	0.000781405	0	0
PKD1L2	114780	broad.mit.edu	37	16	81145910	81145910	+	RNA	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:81145910A>T	ENST00000533478.1	-	0	4896				PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TGTGGACAGGAGTACCAGGAA	0.547000													11	82					0	0	0.000978159	0	0
CETN1	1068	broad.mit.edu	37	18	580762	580762	+	Silent	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr18:580762C>T	ENST00000327228.3	+	1	396	c.354C>T	c.(352-354)acC>acT	p.T118T		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	118	EF-hand 3.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						ACGATGAGACCGGGAAGATCT	0.537000													23	39					0	0	0.00278032	0	0
NDNF	79625	broad.mit.edu	37	4	121958534	121958534	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:121958534G>T	ENST00000379692.4	-	4	1118	c.592C>A	c.(592-594)Cca>Aca	p.P198T	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	198										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						GTGGGGCTTGGTTTCCAGGCC	0.493000													16	115					3.32936e-07	1.86546e-06	0.00074312	1	0
CDH16	1014	broad.mit.edu	37	16	66947070	66947070	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:66947070C>T	ENST00000299752.4	-	9	1211	c.1018G>A	c.(1018-1020)Gac>Aac	p.D340N	CDH16_ENST00000565796.1_Missense_Mutation_p.D340N|CDH16_ENST00000394055.3_Missense_Mutation_p.D340N|CDH16_ENST00000570262.1_Missense_Mutation_p.D260N|CDH16_ENST00000568632.1_Missense_Mutation_p.D243N	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	340					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		ACTGTGGGGTCACGGGGAGGG	0.587000													33	118					0	0	0.00209593	0	0
MKS1	54903	broad.mit.edu	37	17	56291137	56291137	+	Silent	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:56291137T>C	ENST00000393119.2	-	7	812	c.738A>G	c.(736-738)aaA>aaG	p.K246K	MKS1_ENST00000313863.6_Silent_p.K246K|MKS1_ENST00000337050.7_Silent_p.K246K|MKS1_ENST00000546108.1_Silent_p.K43K|MKS1_ENST00000537529.2_Silent_p.K236K	NM_017777.3	NP_060247.2	Q9NXB0	MKS1_HUMAN	Meckel syndrome, type 1	246					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			endometrium(5)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGTAGGGTCCTTTGAGGCCCG	0.473000													32	65					0	0	0.00209593	0	0
KIAA1737	85457	broad.mit.edu	37	14	77579969	77579969	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:77579969A>G	ENST00000361786.2	+	4	825	c.508A>G	c.(508-510)Agg>Ggg	p.R170G	RP11-463C8.4_ENST00000557752.1_Intron	NM_033426.2	NP_219494.2	Q9C0C6	K1737_HUMAN	KIAA1737	170										endometrium(2)|lung(4)|prostate(3)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		TCCAGGCAAAAGGGGCCTTTC	0.488000													3	105					0	0	6.4e-05	0	0
ZNF816	125893	broad.mit.edu	37	19	53454451	53454451	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:53454451G>C	ENST00000357666.4	-	5	877	c.577C>G	c.(577-579)Caa>Gaa	p.Q193E	ZNF816_ENST00000434371.2_Intron|ZNF816_ENST00000444460.2_Missense_Mutation_p.Q193E|ZNF321P_ENST00000391777.3_Intron	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						GAAATTCTTTGGGATTCTGAA	0.378000													31	64					0	0	0.001512	0	0
OR11H12	440153	broad.mit.edu	37	14	19378056	19378056	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:19378056C>A	ENST00000550708.1	+	1	535	c.463C>A	c.(463-465)Ctc>Atc	p.L155I		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GACTGGGCATCTCTGTGCCAA	0.473000													34	436					3.62531e-18	2.19915e-17	0.000814825	1	0
RP11-93K22.13	0	broad.mit.edu	37	3	129811047	129811047	+	RNA	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:129811047A>T	ENST00000514010.1	-	0	157				ALG1L2_ENST00000507643.1_RNA																							CCTGCTGGTCAGCAGCACAAG	0.642000													3	9					0	0	6.4e-05	0	0
ADGRG6	57211	broad.mit.edu	37	6	142718817	142718817	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:142718817C>G	ENST00000230173.6	+	10	1968	c.1492C>G	c.(1492-1494)Cag>Gag	p.Q498E	GPR126_ENST00000367608.2_Missense_Mutation_p.Q470E|GPR126_ENST00000367609.3_Missense_Mutation_p.Q498E|GPR126_ENST00000296932.8_Missense_Mutation_p.Q470E	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	498					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AAAAATCATTCAGCAGAAGCT	0.373000													5	36					0	0	0.000602214	0	0
KCNB2	9312	broad.mit.edu	37	8	73849904	73849904	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:73849904G>C	ENST00000523207.1	+	3	2902	c.2314G>C	c.(2314-2316)Gag>Cag	p.E772Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	772					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GCTGGGCACTGAGGTTTCAGC	0.552000													23	113					0	0	0.00229938	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43692516	43692516	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr10:43692516T>C	ENST00000395809.1	-	11	3762	c.1256A>G	c.(1255-1257)gAg>gGg	p.E419G	RASGEF1A_ENST00000395810.1_Missense_Mutation_p.E419G|RASGEF1A_ENST00000374459.1_Missense_Mutation_p.E427G			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	419	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						TGTCATGAACTCATGGATCTG	0.517000													13	56					0	0	0.00136819	0	0
PLK4	10733	broad.mit.edu	37	4	128814677	128814677	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:128814677A>G	ENST00000270861.5	+	12	2606	c.2332A>G	c.(2332-2334)Att>Gtt	p.I778V	PLK4_ENST00000513090.1_Missense_Mutation_p.I746V|PLK4_ENST00000514379.1_Missense_Mutation_p.I737V|PLK4_ENST00000507249.1_Missense_Mutation_p.I717V|PLK4_ENST00000515069.1_Missense_Mutation_p.I700V	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	778					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						GGGTCATCGTATTTGTTTAGC	0.338000													11	50					0	0	0.000978159	0	0
LCP1	3936	broad.mit.edu	37	13	46716466	46716466	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr13:46716466C>T	ENST00000398576.2	-	16	1851	c.1463G>A	c.(1462-1464)cGc>cAc	p.R488H	LCP1_ENST00000323076.2_Missense_Mutation_p.R488H|LCP1_ENST00000435666.2_Missense_Mutation_p.R57H			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	488	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TGTGAGAGTGCGGTTTCCTTC	0.413000			T	BCL6	NHL								16	97					0	0	0.000958276	0	0
RBMS1	5937	broad.mit.edu	37	2	161138800	161138800	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:161138800T>C	ENST00000392753.3	-	10	1061	c.907A>G	c.(907-909)Aga>Gga	p.R303G	RBMS1_ENST00000348849.3_Intron|RBMS1_ENST00000474820.1_5'UTR|RBMS1_ENST00000409075.1_Intron|RBMS1_ENST00000409972.1_Intron|RBMS1_ENST00000409289.2_Intron			P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting protein 1	300					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding		PLA2R1/RBMS1(2)								TTGTTTTCTCTGGTTTCCTTT	0.453000													45	118					0	0	0.000781405	0	0
OR8J1	219477	broad.mit.edu	37	11	56128447	56128447	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:56128447C>T	ENST00000303039.3	+	1	757	c.725C>T	c.(724-726)gCt>gTt	p.A242V		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					TCTACCTGTGCTTCACATATG	0.348000													35	69					0	0	0.0024448	0	0
C7orf60	154743	broad.mit.edu	37	7	112462082	112462082	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:112462082T>C	ENST00000297145.4	-	5	1100	c.935A>G	c.(934-936)cAt>cGt	p.H312R		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	312										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						CAGATGCATATGTGAAAATTT	0.388000													10	32					0	0	0.000673444	0	0
APITD1	378708	broad.mit.edu	37	1	10494001	10494001	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:10494001G>A	ENST00000602787.1	+	2	570	c.154G>A	c.(154-156)Gag>Aag	p.E52K	APITD1_ENST00000462462.1_Intron|APITD1_ENST00000602296.1_Missense_Mutation_p.E52K|APITD1-CORT_ENST00000400900.2_Missense_Mutation_p.E52K|APITD1-CORT_ENST00000470413.2_Missense_Mutation_p.E52K|APITD1_ENST00000309048.3_Missense_Mutation_p.E52K|APITD1-CORT_ENST00000465026.1_Intron	NM_198544.3	NP_940946.1			apoptosis-inducing, TAF9-like domain 1											kidney(1)|lung(1)|ovary(1)|stomach(1)	4	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GGCCATTTCGGAGCTGACTTT	0.522000													43	125					0	0	0.00195071	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180724	142180724	+	RNA	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:142180724A>T	ENST00000390368.2	-	0	200																											CATGGTTCATATCCTGGGCAC	0.512000													25	373					0	0	0.00106085	0	0
OXA1L	5018	broad.mit.edu	37	14	23240279	23240279	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:23240279C>A	ENST00000358043.5	+	8	1262	c.944C>A	c.(943-945)tCc>tAc	p.S315Y	OXA1L_ENST00000285848.5_Missense_Mutation_p.S391Y|OXA1L_ENST00000604262.1_Missense_Mutation_p.S331Y|OXA1L_ENST00000412791.1_Missense_Mutation_p.S331Y			Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	331					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		GTCCAAGTATCCTGTCTCCGG	0.507000													51	105					2.69953e-25	1.66509e-24	0.000781405	1	0
LRP2	4036	broad.mit.edu	37	2	170134277	170134277	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:170134277C>A	ENST00000263816.3	-	13	2035	c.1750G>T	c.(1750-1752)Gta>Tta	p.V584L	LRP2_ENST00000443831.1_Intron	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	584					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCATAAGTTACAGTTTCAATG	0.388000													25	43					4.26978e-12	2.52743e-11	0.00047179	1	0
LIFR	3977	broad.mit.edu	37	5	38493875	38493875	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:38493875A>G	ENST00000263409.4	-	14	2060	c.1898T>C	c.(1897-1899)aTa>aCa	p.I633T	LIFR_ENST00000453190.2_Missense_Mutation_p.I633T|LIFR_ENST00000503088.1_5'UTR	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	633	Fibronectin type-III 5.		I -> M (in dbSNP:rs2303743).		positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					AACTTGTTCTATTTTGAGATC	0.383000			T	PLAG1	salivary adenoma								20	34					0	0	0.00188189	0	0
KCNK2	3776	broad.mit.edu	37	1	215408401	215408401	+	Silent	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:215408401C>T	ENST00000444842.2	+	7	1344	c.1194C>T	c.(1192-1194)ccC>ccT	p.P398P	KCNK2_ENST00000391895.2_Silent_p.P394P|KCNK2_ENST00000391894.2_Silent_p.P383P	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	398	Essential for chloroform and halothane sensitivity (By similarity).|Required for basal channel activity (By similarity).						outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TCTTGCCTCCCTTACTGAAGA	0.493000													17	37					0	0	0.00074312	0	0
ROBO4	54538	broad.mit.edu	37	11	124756427	124756427	+	Silent	SNP	G	G	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:124756427G>T	ENST00000306534.3	-	16	3212	c.2727C>A	c.(2725-2727)gcC>gcA	p.A909A	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Silent_p.A764A	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	909					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCACTGCCAGGGCCCGGGCAA	0.602000													8	39					5.18039e-06	2.8166e-05	0.000157383	1	0
CDH8	1006	broad.mit.edu	37	16	61687669	61687669	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:61687669C>A	ENST00000577390.1	-	12	3197	c.2243G>T	c.(2242-2244)gGc>gTc	p.G748V	CDH8_ENST00000299345.6_Intron|CDH8_ENST00000577730.1_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	748					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCCTTCATAGCCATATATCTG	0.502000													14	45					6.72482e-11	3.91748e-10	0.000308642	1	0
MUC4	4585	broad.mit.edu	37	3	195498614	195498614	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:195498614G>A	ENST00000463781.3	-	5	13610	c.13151C>T	c.(13150-13152)aCa>aTa	p.T4384I	MUC4_ENST00000349607.4_Missense_Mutation_p.T97I|MUC4_ENST00000475231.1_Missense_Mutation_p.T4384I|MUC4_ENST00000346145.4_Missense_Mutation_p.T148I	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1141					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGAAGCCTGTTGGGAGTGG	0.557000													30	85					0	0	0.00283554	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238672160	238672160	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:238672160T>G	ENST00000244815.5	+	10	1972	c.1732T>G	c.(1732-1734)Tta>Gta	p.L578V	LRRFIP1_ENST00000308482.9_Intron|LRRFIP1_ENST00000289175.6_Missense_Mutation_p.L546V|LRRFIP1_ENST00000392000.4_Missense_Mutation_p.L602V	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	602	DNA-binding.|Lys-rich.				negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		GAACACAGATTTAAGTGAAAT	0.363000													5	11					0	0	0.00116845	0	0
SYNE1	23345	broad.mit.edu	37	6	152757214	152757214	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:152757214C>T	ENST00000367255.5	-	33	4773	c.4172G>A	c.(4171-4173)aGt>aAt	p.S1391N	SYNE1_ENST00000367253.4_Missense_Mutation_p.S1391N|SYNE1_ENST00000265368.4_Missense_Mutation_p.S1391N|SYNE1_ENST00000367248.3_Missense_Mutation_p.S1381N|SYNE1_ENST00000413186.2_Missense_Mutation_p.S1391N|SYNE1_ENST00000423061.1_Missense_Mutation_p.S1398N|SYNE1_ENST00000448038.1_Missense_Mutation_p.S1398N|SYNE1_ENST00000341594.5_Missense_Mutation_p.S1457N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1391					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACTGCAATACTTTCTGTCCG	0.398000										HNSCC(10;0.0054)			7	47					0	0	0.000274275	0	0
FGF7	2252	broad.mit.edu	37	15	49776611	49776611	+	Silent	SNP	T	T	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:49776611T>G	ENST00000267843.4	+	4	1106	c.495T>G	c.(493-495)gtT>gtG	p.V165V	FAM227B_ENST00000561064.1_Intron|FGF7_ENST00000560704.1_3'UTR|FAM227B_ENST00000299338.6_Intron	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	165					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity	p.V165V(1)		kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	AAATGTTTGTTGCCTTAAATC	0.358000													3	32					0	0	0.00024832	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8662012	8662012	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:8662012G>A	ENST00000270328.4	-	7	1165	c.899C>T	c.(898-900)aCt>aTt	p.T300I	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.T300I			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	300	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GATCTCCAGAGTGGGCTGGGG	0.602000													26	65					0	0	0.000878237	0	0
ITGB3	3690	broad.mit.edu	37	17	45360736	45360736	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:45360736C>T	ENST00000559488.1	+	3	198	c.182C>T	c.(181-183)tCa>tTa	p.S61L	ITGB3_ENST00000435993.2_Missense_Mutation_p.S14L|ITGB3_ENST00000571680.1_Missense_Mutation_p.S61L|ITGB3_ENST00000560629.1_Silent_p.L49L	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	61					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	CCTCTGGGCTCACCTCGCTGT	0.567000													21	38					0	0	0.00229938	0	0
NME9	347736	broad.mit.edu	37	3	138037035	138037035	+	Silent	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:138037035G>A	ENST00000383180.2	-	6	393	c.156C>T	c.(154-156)ctC>ctT	p.L52L	NME9_ENST00000333911.3_Silent_p.L74L|NME9_ENST00000341790.5_Intron|NME9_ENST00000317876.4_Silent_p.L52L|NME9_ENST00000536478.1_Silent_p.L52L|NME9_ENST00000484930.1_Intron	NM_178130.2	NP_835231.1	Q86XW9	TXND6_HUMAN	NME/NM23 family member 9	74	Thioredoxin.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TGTACTTTTCGAGGACATCAA	0.458000													46	32					0	0	0.000781405	0	0
PFKFB2	5208	broad.mit.edu	37	1	207240960	207240960	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:207240960G>A	ENST00000367080.3	+	9	873	c.749G>A	c.(748-750)cGc>cAc	p.R250H	PFKFB2_ENST00000367079.2_Missense_Mutation_p.R250H|PFKFB2_ENST00000545806.1_Missense_Mutation_p.R217H|PFKFB2_ENST00000411990.2_Missense_Mutation_p.R152H|PFKFB2_ENST00000541914.1_Missense_Mutation_p.R64H	NM_006212.2	NP_006203.2	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	250	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					GTCCAGCCTCGCACCATTTAC	0.507000													50	114					0	0	0.000781405	0	0
PRB1	5542	broad.mit.edu	37	12	11506741	11506741	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:11506741C>A	ENST00000500254.2	-	3	333	c.296G>T	c.(295-297)gGa>gTa	p.G99V	PRB1_ENST00000546254.1_Missense_Mutation_p.G99V|PRB1_ENST00000545626.1_Missense_Mutation_p.G99V	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	282	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in allele M).			extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGGGGTGGTCCTTGTGGTTT	0.607000													25	507					5.43694e-19	3.32559e-18	0.00111076	1	0
CBWD6	644019	broad.mit.edu	37	9	69238242	69238242	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr9:69238242C>T	ENST00000377457.5	-	8	755	c.650G>A	c.(649-651)aGa>aAa	p.R217K	CBWD6_ENST00000382399.4_Missense_Mutation_p.R197K|CBWD6_ENST00000377449.1_Missense_Mutation_p.R181K	NM_001085457.1	NP_001078926.1	Q4V339	CBWD6_HUMAN	COBW domain containing 6	217							ATP binding			lung(4)	4						AAGTGTCGTTCTTAATTTCTT	0.333000													36	53					0	0	0.00111076	0	0
C3	718	broad.mit.edu	37	19	6697422	6697422	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:6697422A>G	ENST00000245907.6	-	21	2821	c.2729T>C	c.(2728-2730)gTg>gCg	p.V910A		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	910					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTTGACTTCCACTTCCTGCAG	0.567000													29	57					0	0	0.00178596	0	0
ACSL3	2181	broad.mit.edu	37	2	223773571	223773571	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:223773571T>A	ENST00000357430.3	+	4	612	c.81T>A	c.(79-81)caT>caA	p.H27Q	ACSL3_ENST00000392066.3_Missense_Mutation_p.H27Q	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	27					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	ATTTTATACATTTTCTAATAT	0.289000			T	ETV1	prostate								19	39					0	0	0.00074312	0	0
KIAA0232	9778	broad.mit.edu	37	4	6864910	6864910	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:6864910A>G	ENST00000307659.5	+	7	3256	c.2801A>G	c.(2800-2802)tAt>tGt	p.Y934C	KIAA0232_ENST00000425103.1_Missense_Mutation_p.Y934C	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	934							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						GGAGGAGTTTATGGAGAACTC	0.443000													10	37					0	0	0.000673444	0	0
LRFN1	57622	broad.mit.edu	37	19	39804929	39804929	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:39804929G>A	ENST00000248668.4	-	1	1047	c.1048C>T	c.(1048-1050)Cgg>Tgg	p.R350W		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	350	Ig-like.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCGTCCCCCCGGACCCGGGTC	0.692000													9	13					0	0	0.000274275	0	0
FKBP4	2288	broad.mit.edu	37	12	2907902	2907902	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:2907902C>A	ENST00000001008.4	+	4	611	c.424C>A	c.(424-426)Ctg>Atg	p.L142M	RP4-816N1.7_ENST00000547042.1_RNA|RP4-816N1.6_ENST00000547834.1_RNA	NM_002014.3	NP_002005.1	Q02790	FKBP4_HUMAN	FK506 binding protein 4, 59kDa	142					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(1)	14			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	GGGAGAAGATCTGACGGAAGA	0.483000													49	148					5.57489e-27	3.46777e-26	0.000781405	1	0
RGS2	5997	broad.mit.edu	37	1	192780144	192780144	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:192780144C>T	ENST00000235382.5	+	4	339	c.308C>T	c.(307-309)tCg>tTg	p.S103L		NM_002923.3	NP_002914.1	P41220	RGS2_HUMAN	regulator of G-protein signaling 2, 24kDa	103	Necessary to inhibit protein synthesis.|RGS.				cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity			large_intestine(3)|lung(1)|urinary_tract(1)	5						TTTTTAAAGTCGGAATTCTGT	0.398000													36	88					0	0	0.00128727	0	0
SEMA3E	9723	broad.mit.edu	37	7	83119474	83119474	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:83119474C>G	ENST00000307792.3	-	2	699	c.232G>C	c.(232-234)Gta>Cta	p.V78L	SEMA3E_ENST00000427262.1_Missense_Mutation_p.V18L	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	78	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				AGGGAATATACAAGGTCCCTG	0.413000													8	45					0	0	0.000274275	0	0
KCNA1	3736	broad.mit.edu	37	12	5021157	5021157	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:5021157A>T	ENST00000382545.3	+	2	1720	c.613A>T	c.(613-615)Atc>Ttc	p.I205F	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	205					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGTCCACCGCATCGACAACAC	0.537000													19	48					0	0	0.00074312	0	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89917883	89917883	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:89917883C>A	ENST00000548729.1	-	3	737	c.435G>T	c.(433-435)tgG>tgT	p.W145C	POC1B-GALNT4_ENST00000413530.1_Intron|POC1B-GALNT4_ENST00000547474.1_Intron|POC1B_ENST00000541909.1_Intron|POC1B_ENST00000549035.1_Intron|POC1B_ENST00000393179.4_Intron|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000313546.3_Intron|GALNT4_ENST00000529983.2_Missense_Mutation_p.W148C	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					GCAAAGTCGACCAGGCTTCGT	0.398000											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	45					1.33834e-09	7.61503e-09	0.000958276	1	0
TP53	7157	broad.mit.edu	37	17	7578520	7578520	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:7578520A>T	ENST00000420246.2	-	5	542	c.410T>A	c.(409-411)cTg>cAg	p.L137Q	TP53_ENST00000413465.2_Missense_Mutation_p.L137Q|TP53_ENST00000445888.2_Missense_Mutation_p.L137Q|TP53_ENST00000359597.4_Missense_Mutation_p.L137Q|TP53_ENST00000455263.2_Missense_Mutation_p.L137Q|TP53_ENST00000269305.4_Missense_Mutation_p.L137Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	137	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		L -> M (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> Q (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.L137P(3)|p.C135fs*9(3)|p.N131fs*27(2)|p.L137Q(2)|p.V73fs*9(1)|p.L137_W146del10(1)|p.C135_T140delCQLAKT(1)|p.C42fs*9(1)|p.K132_A138delKMFCQLA(1)|p.F134_T140>S(1)|p.C3fs*9(1)|p.Q136_K139delQLAK(1)|p.L137_A138insX(1)|p.C135_A138delCQLA(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTCTTGGCCAGTTGGCAAAA	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	21					0	0	0.00106085	0	0
ZNF546	339327	broad.mit.edu	37	19	40520758	40520758	+	Silent	SNP	T	T	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:40520758T>C	ENST00000347077.4	+	7	1797	c.1581T>C	c.(1579-1581)tgT>tgC	p.C527C	ZNF546_ENST00000596894.1_Intron|ZNF546_ENST00000600094.1_Silent_p.C501C	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CCTACATATGTAACGAATGTG	0.403000													23	41					0	0	0.00278032	0	0
LPAR3	23566	broad.mit.edu	37	1	85331609	85331609	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:85331609delG	ENST00000440886.1	-	1	233	c.195delC	c.(193-195)ttfs	p.F65fs	LPAR3_ENST00000370611.3_Frame_Shift_Del_p.F65fs|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	65					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						ACAGGTAGTAGAAGGGGAAAT	0.393													56	83	---	---	---	---					
AP5M1	55745	broad.mit.edu	37	14	57741158	57741159	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:57741158_57741159insA	ENST00000261558.3	+	2	677_678	c.271_272insA	c.(271-273)agafs	p.R91fs	AP5M1_ENST00000431972.2_Frame_Shift_Ins_p.R105fs	NM_018229.3	NP_060699.3	Q9H0R1	MUDEN_HUMAN	adaptor-related protein complex 5, mu 1 subunit	91					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex											GATAGGAGGTGAAGAACTCTGG	0.406													21	45	---	---	---	---					
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	CCT	-	rs3832971		TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:71275774_71275776delCCT	ENST00000554752.2	-	1	112_114	c.113_115delAGG	c.(112-117)gcg>g	p.EA38del	MAP3K9_ENST00000555993.2_In_Frame_Del_p.EA38del|MAP3K9_ENST00000381250.4_In_Frame_Del_p.EA38del			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.E38delE(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.773													4	3	---	---	---	---					
JAG2	3714	broad.mit.edu	37	14	105613864	105613864	+	Splice_Site	DEL	T	T	-			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:105613864delT	ENST00000331782.3	-	19	2769	c.2365_splice	c.e19-1	p.N789_splice	JAG2_ENST00000347004.2_Splice_Site_p.N751_splice	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	789	EGF-like 15; calcium-binding (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GTCGTTGGTATCTGGTTTGGG	0.652													12	28	---	---	---	---					
MZF1	7593	broad.mit.edu	37	19	59073795	59073796	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:59073795_59073796insC	ENST00000215057.2	-	6	2408_2409	c.1848_1849insG	c.(1846-1851)caggacfs	p.D617fs	MZF1_ENST00000594234.1_3'UTR|AC016629.8_ENST00000600534.1_RNA|AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000599369.1_Frame_Shift_Ins_p.D617fs|AC016629.8_ENST00000600726.1_RNA	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	617					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GTGTGTGTCCTCTGATGACGCG	0.663													9	20	---	---	---	---					
SCARF2	91179	broad.mit.edu	37	22	20781751	20781752	+	Frame_Shift_Ins	INS	-	-	GGACC			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr22:20781751_20781752insGGACC	ENST00000405555.3	-	10	1696_1697	c.1626_1627insGGTCC	c.(1624-1629)tcctcgfs	p.S543fs	SCARF2_ENST00000266214.5_Frame_Shift_Ins_p.S548fs	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	543					cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GAGGCCCGAGAGGACCAGGATG	0.599													9	82	---	---	---	---