Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTMR8	55613	broad.mit.edu	37	X	63444272	63444272	+	Silent	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chrX:63444272G>A	ENST00000453546.1	-	11	2114	c.2025C>T	c.(2023-2025)gcC>gcT	p.A675A	ASB12_ENST00000396130.2_Silent_p.A291A|ASB12_ENST00000362002.2_Silent_p.A300A			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						GCTGGTTGATGGCTTGTGGCT	0.507000													4	36					0	0	0.001168	0	0
CDHR2	54825	broad.mit.edu	37	5	176018404	176018404	+	Splice_Site	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr5:176018404G>A	ENST00000510636.1	+	30	3927		c.e30-1		CDHR2_ENST00000261944.5_Splice_Site|CDHR2_ENST00000506348.1_Splice_Site	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2						homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TTTCTCTCCAGAGCCAACCCC	0.577000													11	53					0	0	0.008291	0	0
HERC2	8924	broad.mit.edu	37	15	28538128	28538128	+	Silent	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr15:28538128C>T	ENST00000261609.7	-	4	336	c.228G>A	c.(226-228)ctG>ctA	p.L76L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	76					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTTTGTCATTCAGATCTTCTT	0.393000													8	71					0	0	0.003080	0	0
NPY5R	4889	broad.mit.edu	37	4	164272135	164272135	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:164272135G>A	ENST00000515560.1	+	4	2232	c.710G>A	c.(709-711)aGt>aAt	p.S237N	NPY5R_ENST00000338566.3_Missense_Mutation_p.S237N|NPY5R_ENST00000506953.1_Missense_Mutation_p.S237N			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	237					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				GTCTGCAGAAGTATAAGCTGT	0.368000													19	61					0	0	0.007413	0	0
GSE1	23199	broad.mit.edu	37	16	85699645	85699645	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr16:85699645C>T	ENST00000253458.7	+	13	2998	c.2822C>T	c.(2821-2823)tCt>tTt	p.S941F	GSE1_ENST00000405402.2_Missense_Mutation_p.S837F|GSE1_ENST00000393243.1_Missense_Mutation_p.S868F	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		GCTTCCTTGTCTGACATCCCA	0.567000													3	44					0	0	0.000248	0	0
SERPINB4	6318	broad.mit.edu	37	18	61309020	61309020	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr18:61309020C>T	ENST00000341074.5	-	4	440	c.325G>A	c.(325-327)Gga>Aga	p.G109R	SERPINB4_ENST00000356424.6_Missense_Mutation_p.G109R	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4									p.G109*(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						GTCTTTTCTCCGAAGAGCTTG	0.413000													11	80					0	0	0.001368	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319866	21319866	+	Silent	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:21319866C>T	ENST00000583088.1	+	3	2107	c.1212C>T	c.(1210-1212)ctC>ctT	p.L404L	KCNJ12_ENST00000331718.5_Silent_p.L404L	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGGACGGCCTCAGCCCCCAGG	0.662000										Prostate(3;0.18)			5	75					0	0	0.000602	0	0
PIWIL1	9271	broad.mit.edu	37	12	130840124	130840124	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:130840124G>A	ENST00000245255.3	+	12	1588	c.1316G>A	c.(1315-1317)cGa>cAa	p.R439Q		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	439					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AGGGAGCTTCGAGACTGGGGT	0.393000													15	158					0	0	0.004007	0	0
GLI2	2736	broad.mit.edu	37	2	121729595	121729595	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:121729595G>A	ENST00000452319.1	+	8	1198	c.1138G>A	c.(1138-1140)Gag>Aag	p.E380K	GLI2_ENST00000314490.11_Missense_Mutation_p.E52K|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.E380K			P10070	GLI2_HUMAN	GLI family zinc finger 2	380					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGTCAAGACCGAGCCTGAGGG	0.647000													9	62					0	0	0.006214	0	0
SMARCC2	6601	broad.mit.edu	37	12	56572620	56572620	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:56572620C>T	ENST00000394023.3	-	13	1258	c.1153G>A	c.(1153-1155)Gat>Aat	p.D385N	SMARCC2_ENST00000347471.4_Missense_Mutation_p.D385N|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Missense_Mutation_p.D385N|SMARCC2_ENST00000267064.4_Missense_Mutation_p.D385N	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	385					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			ATGCTTTCATCTTCCTGTTCA	0.483000													4	46					0	0	0.000248	0	0
COL8A1	1295	broad.mit.edu	37	3	99509630	99509630	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr3:99509630C>T	ENST00000261037.3	+	4	484	c.104C>T	c.(103-105)cCg>cTg	p.P35L	COL8A1_ENST00000273342.4_Missense_Mutation_p.P35L	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	35	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGGATCAAGCCGCTGCCACCT	0.557000													4	95					0	0	0.000602	0	0
PTK7	5754	broad.mit.edu	37	6	43113061	43113061	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr6:43113061G>A	ENST00000230419.4	+	16	2752	c.2531G>A	c.(2530-2532)cGg>cAg	p.R844Q	PTK7_ENST00000481273.1_Missense_Mutation_p.R852Q|PTK7_ENST00000352931.2_Missense_Mutation_p.R788Q|PTK7_ENST00000349241.2_Missense_Mutation_p.R714Q|PTK7_ENST00000345201.2_Missense_Mutation_p.R804Q	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	844	Interaction with CTNNB1.|Protein kinase; inactive.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CTGGACTTCCGGAGGGAGTTG	0.602000													13	52					0	0	0.001855	0	0
OR2L13	284521	broad.mit.edu	37	1	248263541	248263541	+	Silent	SNP	C	C	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:248263541C>A	ENST00000366478.2	+	3	1201	c.864C>A	c.(862-864)atC>atA	p.I288I	OR2L13_ENST00000358120.2_Silent_p.I288I	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATCCCATTATCTACAGCCTGA	0.493000													8	59					0.00448238	0.00563693	0.004482	1	0
ZNF208	7757	broad.mit.edu	37	19	22154658	22154658	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:22154658C>T	ENST00000397126.4	-	4	3326	c.3178G>A	c.(3178-3180)Gaa>Aaa	p.E1060K	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCACATTCTTCACATTTGTAG	0.463000													8	145					0	0	0.004482	0	0
PODXL	5420	broad.mit.edu	37	7	131195709	131195709	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:131195709G>A	ENST00000541194.1	-	2	847	c.590C>T	c.(589-591)aCg>aTg	p.T197M	PODXL_ENST00000378555.3_Missense_Mutation_p.T195M|PODXL_ENST00000322985.9_Missense_Mutation_p.T195M|PODXL_ENST00000537928.1_Missense_Mutation_p.T195M	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	195	Thr-rich.				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.T195M(1)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					CACAGGATGCGTCGAAGTGGG	0.537000													6	81					0	0	0.001168	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475709	75475709	+	RNA	SNP	T	T	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr3:75475709T>C	ENST00000459803.1	-	0	820					NR_024241.1													p.I261V(1)									CTCCGCAGGATCCCGACCAGC	0.562000													5	53					0	0	0.000602	0	0
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	rs121912651		TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:7577539G>A	ENST00000420246.2	-	7	874	c.742C>T	c.(742-744)Cgg>Tgg	p.R248W	TP53_ENST00000269305.4_Missense_Mutation_p.R248W|TP53_ENST00000413465.2_Missense_Mutation_p.R248W|TP53_ENST00000359597.4_Missense_Mutation_p.R248W|TP53_ENST00000445888.2_Missense_Mutation_p.R248W|TP53_ENST00000455263.2_Missense_Mutation_p.R248W	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248W(544)|p.R155W(28)|p.R248G(12)|p.0?(8)|p.?(5)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248R(2)|p.R248fs*>39(1)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577000	R248W(786O_KIDNEY)|R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO320_LARGE_INTESTINE)|R248W(COLO680N_OESOPHAGUS)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(GCT_SOFT_TISSUE)|R248W(HCC2157_BREAST)|R248W(JIMT1_BREAST)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(LUDLU1_LUNG)|R248W(LXF289_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(RD_SOFT_TISSUE)|R248W(SW837_LARGE_INTESTINE)|R248W(VCAP_PROSTATE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	50					0	0	0.003163	0	0
VWA7	80737	broad.mit.edu	37	6	31736952	31736952	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr6:31736952G>C	ENST00000375686.3	-	10	1583	c.1346C>G	c.(1345-1347)tCa>tGa	p.S449*	VWA7_ENST00000375688.4_Nonsense_Mutation_p.S449*|VWA7_ENST00000467576.1_5'UTR|VWA7_ENST00000447450.1_Nonsense_Mutation_p.S449*	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	449						extracellular region											CTGAACCCTTGATGTATCTTC	0.522000													4	66					0	0	0.000248	0	0
TRPV1	7442	broad.mit.edu	37	17	3470183	3470183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:3470183G>A	ENST00000174621.6	-	15	2729	c.2440C>T	c.(2440-2442)Cga>Tga	p.R814*	TRPV1_ENST00000571088.1_Nonsense_Mutation_p.R816*|SHPK_ENST00000572705.1_Nonsense_Mutation_p.R816*|TRPV1_ENST00000425167.2_Nonsense_Mutation_p.R827*|TRPV1_ENST00000310522.5_Nonsense_Mutation_p.R756*|TRPV1_ENST00000399756.4_Nonsense_Mutation_p.R816*|TRPV1_ENST00000576351.1_Nonsense_Mutation_p.R806*|TRPV1_ENST00000399759.3_Nonsense_Mutation_p.R816*			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	816					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GAAAACTGTCGCAGATAAACT	0.547000													5	39					0	0	0.000602	0	0
EML5	161436	broad.mit.edu	37	14	89130941	89130941	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr14:89130941G>C	ENST00000554922.1	-	23	3553	c.3305C>G	c.(3304-3306)tCc>tGc	p.S1102C	EML5_ENST00000380664.5_Missense_Mutation_p.S1102C|EML5_ENST00000352093.5_Missense_Mutation_p.S1064C	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1102						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCTGTCATGGGATGCTACAGC	0.328000													4	65					0	0	0.000248	0	0
EEFSEC	60678	broad.mit.edu	37	3	127983609	127983609	+	Silent	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr3:127983609G>A	ENST00000254730.6	+	4	825	c.771G>A	c.(769-771)gaG>gaA	p.E257E	EEFSEC_ENST00000483457.1_Intron	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	257						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						ACAGTGTGGAGATCCCTGCCC	0.567000													7	58					0	0	0.001984	0	0
AUTS2	26053	broad.mit.edu	37	7	70236612	70236612	+	Silent	SNP	A	A	G			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:70236612A>G	ENST00000342771.4	+	11	2133	c.1812A>G	c.(1810-1812)caA>caG	p.Q604Q	AUTS2_ENST00000406775.2_Silent_p.Q604Q	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	604										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GTTCACTACAAGGAGCATTTC	0.567000													8	99					0	0	0.004482	0	0
NCK2	8440	broad.mit.edu	37	2	106497876	106497876	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:106497876G>A	ENST00000233154.4	+	4	761	c.319G>A	c.(319-321)Gac>Aac	p.D107N	NCK2_ENST00000393349.2_Missense_Mutation_p.D107N|NCK2_ENST00000451463.2_Intron|NCK2_ENST00000522586.1_Intron	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	107					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CAGCGGCGCCGACCGCATCTA	0.682000													9	56					0	0	0.004482	0	0
SMARCC2	6601	broad.mit.edu	37	12	56575490	56575490	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:56575490C>A	ENST00000394023.3	-	9	943	c.838G>T	c.(838-840)Gag>Tag	p.E280*	SMARCC2_ENST00000347471.4_Nonsense_Mutation_p.E280*|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Nonsense_Mutation_p.E280*|SMARCC2_ENST00000267064.4_Nonsense_Mutation_p.E280*	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	280					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTTGTCACCTCATCTGTCAGT	0.433000													9	113					0.00621372	0.00769759	0.006214	1	0
ZBTB18	10472	broad.mit.edu	37	1	244218372	244218372	+	Silent	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:244218372C>T	ENST00000358704.4	+	2	1445	c.1296C>T	c.(1294-1296)taC>taT	p.Y432Y		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		CTTGCATGTACACCCTCAAGC	0.627000													7	76					0	0	0.003080	0	0
CADPS2	93664	broad.mit.edu	37	7	122194724	122194724	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:122194724G>C	ENST00000334010.7	-	8	1776	c.1355C>G	c.(1354-1356)tCt>tGt	p.S452C	CADPS2_ENST00000449022.2_Missense_Mutation_p.S452C|CADPS2_ENST00000412584.2_Missense_Mutation_p.S452C|CADPS2_ENST00000476131.1_5'UTR|CADPS2_ENST00000313070.7_Missense_Mutation_p.S452C	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	452					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						GGAGCTATTAGAAGTTGGGTA	0.358000													4	31					0	0	0.000248	0	0
GPR25	2848	broad.mit.edu	37	1	200842880	200842880	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:200842880C>T	ENST00000304244.2	+	1	798	c.715C>T	c.(715-717)Cgg>Tgg	p.R239W		NM_005298.2	NP_005289.2	O00155	GPR25_HUMAN	G protein-coupled receptor 25	239						integral to plasma membrane				large_intestine(1)|lung(2)|ovary(1)|skin(1)	5						GGGTCGGGCCCGGAGGAACTC	0.692000													5	58					0	0	0.000602	0	0
NAA11	84779	broad.mit.edu	37	4	80246805	80246805	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:80246805G>A	ENST00000286794.4	-	1	399	c.227C>T	c.(226-228)gCc>gTc	p.A76V		NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	76	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						ACGCTTCACGGCCAGTGAGGT	0.562000													10	96					0	0	0.006214	0	0
ADARB2	105	broad.mit.edu	37	10	1284215	1284215	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr10:1284215G>A	ENST00000381312.1	-	5	1665	c.1340C>T	c.(1339-1341)aCg>aTg	p.T447M		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	447	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CTCCAGCTGCGTGTAGAGGAA	0.701000													4	19					0	0	0.001168	0	0
IQCD	115811	broad.mit.edu	37	12	113633454	113633454	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:113633454G>A	ENST00000416617.2	-	5	1466	c.1276C>T	c.(1276-1278)Cgg>Tgg	p.R426W	IQCD_ENST00000299732.2_Missense_Mutation_p.R324W			Q96DY2	IQCD_HUMAN	IQ motif containing D	426	IQ.									endometrium(2)|large_intestine(4)|lung(1)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						cccttgccccgcttcttctTG	0.607000													22	103					0	0	0.003330	0	0
PTCH1	5727	broad.mit.edu	37	9	98220448	98220448	+	Silent	SNP	C	C	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr9:98220448C>A	ENST00000430669.2	-	18	3402	c.2817G>T	c.(2815-2817)ggG>ggT	p.G939G	PTCH1_ENST00000331920.6_Silent_p.G1005G|PTCH1_ENST00000418258.1_Silent_p.G854G|PTCH1_ENST00000429896.2_Silent_p.G854G|PTCH1_ENST00000421141.1_Silent_p.G854G|PTCH1_ENST00000375274.2_Silent_p.G1004G|PTCH1_ENST00000437951.1_Silent_p.G939G			Q13635	PTC1_HUMAN	patched 1	1005					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.I963fs*2(1)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AACTGGACAGCCCCAGGCTCG	0.567000													22	68					0.000295444	0.000377259	0.002299	1	0
H3F3C	440093	broad.mit.edu	37	12	31944914	31944914	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:31944914G>A	ENST00000340398.3	-	1	261	c.187C>T	c.(187-189)Cgg>Tgg	p.R63W		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	63					nucleosome assembly	nucleosome|nucleus	DNA binding	p.R63R(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						GGCAGCTTCCGGATGAGCAGC	0.612000										HNSCC(67;0.2)			3	85					0	0	0.004672	0	0
FAM13A	10144	broad.mit.edu	37	4	89950619	89950619	+	Translation_Start_Site	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:89950619G>A	ENST00000511976.1	-	0	404				FAM13A_ENST00000515600.1_Missense_Mutation_p.T70M|FAM13A_ENST00000264344.5_Missense_Mutation_p.T70M|FAM13A_ENST00000509094.1_Missense_Mutation_p.T70M|FAM13A_ENST00000502459.1_5'UTR			O94988	FA13A_HUMAN	family with sequence similarity 13, member A						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						ACCATGCTGCGTCAAATATTC	0.393000													4	152					0	0	0.000248	0	0
INPP1	3628	broad.mit.edu	37	2	191235874	191235874	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:191235874G>T	ENST00000392329.2	+	7	1646	c.946G>T	c.(946-948)Gac>Tac	p.D316Y	INPP1_ENST00000541441.1_Missense_Mutation_p.D316Y|INPP1_ENST00000322522.4_Missense_Mutation_p.D316Y	NM_001128928.1	NP_001122400.1	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	316					signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	ATTCAAATGGGACTCTTGTGC	0.463000													5	94					5.9392e-07	7.7024e-07	0.001168	1	0
SGIP1	84251	broad.mit.edu	37	1	67195004	67195004	+	Silent	SNP	A	A	G			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:67195004A>G	ENST00000371037.4	+	20	1877	c.1800A>G	c.(1798-1800)agA>agG	p.R600R	SGIP1_ENST00000371036.3_Silent_p.R402R|SGIP1_ENST00000371039.1_Silent_p.R403R|SGIP1_ENST00000237247.6_Silent_p.R631R|SGIP1_ENST00000371035.3_Silent_p.R390R|SGIP1_ENST00000435165.2_Silent_p.R105R	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	600					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						GCATCACCAGACACTTTGCCA	0.468000													7	86					0	0	0.001984	0	0
ZNF675	171392	broad.mit.edu	37	19	23836193	23836193	+	Silent	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:23836193G>A	ENST00000359788.4	-	4	1710	c.1542C>T	c.(1540-1542)ggC>ggT	p.G514G	ZNF675_ENST00000600313.1_Intron|ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000601935.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	514				G -> S (in Ref. 1; AAK95822).	bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TAAAAGCTTTGCCACATTCTT	0.368000													7	35					0	0	0.001984	0	0
VCAN	1462	broad.mit.edu	37	5	82817997	82817997	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr5:82817997C>G	ENST00000265077.3	+	7	4437	c.3872C>G	c.(3871-3873)aCa>aGa	p.T1291R	VCAN_ENST00000343200.5_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.T1291R|VCAN_ENST00000512590.2_Missense_Mutation_p.T1243R	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1291	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACACAGCCAACAAGACCACCC	0.478000													13	86					0	0	0.001368	0	0
DNAJB2	3300	broad.mit.edu	37	2	220144591	220144591	+	Silent	SNP	A	A	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:220144591A>T	ENST00000336576.5	+	2	324	c.36A>T	c.(34-36)cgA>cgT	p.R12R	DNAJB2_ENST00000392086.4_Silent_p.R12R	NM_006736.5	NP_006727.2	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	12	J.				ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGTGCCGCGAAGTGCGTCCG	0.592000													15	60					0	0	0.004990	0	0
MUTYH	4595	broad.mit.edu	37	1	45799087	45799087	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:45799087G>A	ENST00000450313.1	-	3	561	c.346C>T	c.(346-348)Cgg>Tgg	p.R116W	MUTYH_ENST00000355498.2_Missense_Mutation_p.R88W|MUTYH_ENST00000448481.1_Missense_Mutation_p.R99W|MUTYH_ENST00000488731.2_Intron|MUTYH_ENST00000354383.6_Missense_Mutation_p.R89W|MUTYH_ENST00000531105.1_Intron|MUTYH_ENST00000529984.1_Intron|MUTYH_ENST00000528332.2_Intron|MUTYH_ENST00000372104.1_Missense_Mutation_p.R88W|MUTYH_ENST00000456914.2_Missense_Mutation_p.R88W|MUTYH_ENST00000372110.3_Missense_Mutation_p.R103W|MUTYH_ENST00000372098.3_Missense_Mutation_p.R113W|MUTYH_ENST00000372100.5_Missense_Mutation_p.R99W|MUTYH_ENST00000372115.3_Missense_Mutation_p.R102W	NM_001128425.1|NM_012222.2	NP_001121897.1|NP_036354.1	Q9UIF7	MUTYH_HUMAN	mutY homolog	113					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					CTGCCTACCCGTCTTCTCCAT	0.582000			Mis			colorectal		Base excision repair (BER), DNA glycosylases	MUTYH-associated polyposis				8	80					0	0	0.004482	0	0
AFAP1	60312	broad.mit.edu	37	4	7840316	7840316	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:7840316G>C	ENST00000420658.1	-	6	933	c.661C>G	c.(661-663)Cag>Gag	p.Q221E	AFAP1_ENST00000382543.3_Missense_Mutation_p.Q221E|AFAP1_ENST00000358461.2_Missense_Mutation_p.Q221E|AFAP1_ENST00000360265.4_Missense_Mutation_p.Q221E	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	221	PH 1.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						GTGCCCTGCTGAGTAATCTTC	0.532000													3	77					0	0	0.004672	0	0
PSMD3	5709	broad.mit.edu	37	17	38142872	38142872	+	Silent	SNP	A	A	G			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:38142872A>G	ENST00000264639.4	+	3	630	c.456A>G	c.(454-456)ggA>ggG	p.G152G	PSMD3_ENST00000541736.1_Silent_p.G14G	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	152					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					CCCGCACGGGAAAAGCTGCGT	0.512000													3	184					0	0	0.004672	0	0
STAM2	10254	broad.mit.edu	37	2	153000432	153000432	+	Missense_Mutation	SNP	G	G	A	rs137997902		TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:153000432G>A	ENST00000263904.4	-	7	962	c.613C>T	c.(613-615)Cgg>Tgg	p.R205W	STAM2_ENST00000465460.1_5'UTR	NM_005843.4	NP_005834.4	O75886	STAM2_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	205	SH3.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.22)		CTCACTTTCCGTGCAACCTTA	0.333000													6	47					0	0	0.001984	0	0
AOC1	26	broad.mit.edu	37	7	150553561	150553561	+	Translation_Start_Site	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:150553561G>A	ENST00000493429.1	+	4	587	c.3G>A	c.(1-3)atG>atA	p.M1I	AOC1_ENST00000360937.4_Start_Codon_SNP_p.M1I|AOC1_ENST00000416793.2_Start_Codon_SNP_p.M1I|AOC1_ENST00000467291.1_Start_Codon_SNP_p.M1I					amine oxidase, copper containing 1																		AGCGAGAGATGCCGGCCCTGG	0.607000													6	48					0	0	0.001984	0	0
FAM45B	55855	broad.mit.edu	37	X	129629115	129629115	+	RNA	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chrX:129629115G>A	ENST00000458525.1	-	0	1080				FAM45B_ENST00000592932.1_RNA																							TTAGAGCTGCGCGCCGCGGCG	0.537000													3	23					0	0	0.004672	0	0
TRPM2	7226	broad.mit.edu	37	21	45837846	45837846	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr21:45837846G>C	ENST00000397928.1	+	21	3628	c.3183G>C	c.(3181-3183)caG>caC	p.Q1061H	TRPM2_ENST00000300482.5_Missense_Mutation_p.Q1061H|TRPM2_ENST00000397932.2_Missense_Mutation_p.Q1061H|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.Q1041H	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1061						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ACACGGACCAGATTTGGAAGT	0.612000													4	66					0	0	0.000248	0	0
KIAA0556	23247	broad.mit.edu	37	16	27751578	27751578	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr16:27751578G>A	ENST00000261588.4	+	15	1979	c.1960G>A	c.(1960-1962)Gag>Aag	p.E654K		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	654										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CGGGGACAAGGAGCTTGGTCT	0.507000													6	68					0	0	0.001984	0	0
FCGBP	8857	broad.mit.edu	37	19	40368837	40368837	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:40368837C>T	ENST00000221347.6	-	28	12518	c.12511G>A	c.(12511-12513)Gac>Aac	p.D4171N		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4171	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ATCCGCCCGTCGGCCACGGAG	0.617000													6	433					0	0	0.001984	0	0
NKAP	79576	broad.mit.edu	37	X	119077227	119077227	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chrX:119077227C>T	ENST00000371410.3	-	1	508	c.342G>A	c.(340-342)tgG>tgA	p.W114*		NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	114					negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						GGAGGCTAGGCCAAGGCTTGT	0.637000													8	39					0	0	0.003080	0	0
NTRK1	4914	broad.mit.edu	37	1	156837972	156837972	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:156837972G>A	ENST00000368196.3	+	5	625	c.505G>A	c.(505-507)Gga>Aga	p.G169R	NTRK1_ENST00000524377.1_Missense_Mutation_p.G169R|NTRK1_ENST00000358660.3_Missense_Mutation_p.G169R|NTRK1_ENST00000392302.2_Missense_Mutation_p.G139R	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	169	LRRCT.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGGACTGGGCGGAGTGCCTGA	0.657000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			7	64					0	0	0.003080	0	0
KDM3B	51780	broad.mit.edu	37	5	137727716	137727716	+	Silent	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr5:137727716C>T	ENST00000314358.5	+	8	2595	c.2395C>T	c.(2395-2397)Ctg>Ttg	p.L799L	KDM3B_ENST00000542866.1_Intron|KDM3B_ENST00000394866.1_Silent_p.L455L	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	799					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						AAGGTTCTCACTGGATGAACG	0.512000													29	207					0	0	0.007291	0	0
RINL	126432	broad.mit.edu	37	19	39361610	39361610	+	Silent	SNP	G	G	A			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:39361610G>A	ENST00000340740.3	-	8	669	c.282C>T	c.(280-282)caC>caT	p.H94H	RINL_ENST00000591812.1_Silent_p.H208H|RINL_ENST00000598904.1_Silent_p.H94H|CTC-360G5.6_ENST00000593830.1_RNA	NM_001195833.1|NM_198445.3	NP_001182762.1|NP_940847.1	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	94							GTPase activator activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|urinary_tract(2)	17						AGGAGACCCCGTGAGGCGCAG	0.672000													13	96					0	0	0.001368	0	0
WDR48	57599	broad.mit.edu	37	3	39116272	39116272	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr3:39116272G>C	ENST00000302313.5	+	8	756	c.728G>C	c.(727-729)aGa>aCa	p.R243T	WDR48_ENST00000418020.1_5'UTR|WDR48_ENST00000396258.3_Missense_Mutation_p.R161T|WDR48_ENST00000544962.1_Missense_Mutation_p.R35T	NM_020839.2	NP_065890.1	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	243					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			breast(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GGCCAGCAGAGATGTATAGCA	0.478000													14	54					0	0	0.004007	0	0
KCTD8	386617	broad.mit.edu	37	4	44450256	44450256	+	Silent	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:44450256C>T	ENST00000360029.3	-	1	568	c.285G>A	c.(283-285)gcG>gcA	p.A95A		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	95	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TGAAGAAGCGCGCCCGGCTGT	0.667000										HNSCC(17;0.042)			4	24					0	0	0.000248	0	0
TMEM216	51259	broad.mit.edu	37	11	61165278	61165278	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr11:61165278C>T	ENST00000515837.2	+	4	1207	c.262C>T	c.(262-264)Ccg>Tcg	p.P88S	TMEM216_ENST00000334888.5_Missense_Mutation_p.P88S|TMEM216_ENST00000398979.3_Missense_Mutation_p.P27S			Q9P0N5	TM216_HUMAN	transmembrane protein 216	81						integral to membrane				endometrium(1)|large_intestine(2)|lung(1)|prostate(2)	6						GCGAAAGATGCCGCTCAGTAT	0.552000													4	124					0	0	0.000248	0	0
ZNF473	25888	broad.mit.edu	37	19	50548556	50548556	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:50548556C>G	ENST00000595661.1	+	6	1351	c.856C>G	c.(856-858)Cac>Gac	p.H286D	ZNF473_ENST00000445728.3_Missense_Mutation_p.H274D|ZNF473_ENST00000601364.1_Intron|ZNF473_ENST00000391821.2_Missense_Mutation_p.H286D|CTD-2126E3.3_ENST00000599410.1_RNA|CTD-2126E3.3_ENST00000599914.1_RNA|ZNF473_ENST00000270617.3_Missense_Mutation_p.H286D			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	286					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TCAGAAAACTCACACTGGAGA	0.428000													8	94					0	0	0.003080	0	0
TXLNB	167838	broad.mit.edu	37	6	139609822	139609822	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr6:139609822G>C	ENST00000358430.3	-	2	447	c.215C>G	c.(214-216)tCt>tGt	p.S72C		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	72						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GCTGGCAGCAGACCCATAAGT	0.542000													14	118					0	0	0.003163	0	0
AP5M1	55745	broad.mit.edu	37	14	57746958	57746958	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr14:57746958C>T	ENST00000261558.3	+	3	1172	c.766C>T	c.(766-768)Ctc>Ttc	p.L256F	AP5M1_ENST00000556723.1_3'UTR|AP5M1_ENST00000431972.2_Missense_Mutation_p.L270F	NM_018229.3	NP_060699.3	Q9H0R1	MUDEN_HUMAN	adaptor-related protein complex 5, mu 1 subunit	256	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex											CAGCTTGAGTCTCCCCACCAA	0.398000													10	172					0	0	0.000978	0	0
FAM66B	100128890	broad.mit.edu	37	8	7196263	7196264	+	RNA	DEL	AC	AC	-			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr8:7196263_7196264delAC	ENST00000606573.1	-	0	703																											ACTGAGGGGTacacacacacac	0.500													3	2	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													3	6	---	---	---	---					
KRT17P1	147228	broad.mit.edu	37	17	16748911	16748913	+	RNA	DEL	GCT	GCT	-			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:16748911_16748913delGCT	ENST00000580363.1	-	0	282_284																				lung(4)	4						CGCCCTCAAAGCTGCTGCTGCCA	0.650													3	3	---	---	---	---					
FRG1BP	284802	broad.mit.edu	37	20	29628226	29628226	+	Splice_Site	DEL	G	G	-	rs78710112	by1000genomes	TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr20:29628226delG	ENST00000278882.3	+	6	608		c.e6-1		FRG1B_ENST00000439954.2_Splice_Site|FRG1B_ENST00000358464.4_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTTCACTTAGGGGAAAATGG	0.358													7	67	---	---	---	---