Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HGFAC	3083	broad.mit.edu	37	4	3445789	3445789	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:3445789G>A	ENST00000382774.3	+	5	614	c.499G>A	c.(499-501)Ggc>Agc	p.G167S	HGFAC_ENST00000511533.1_Missense_Mutation_p.G167S	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	167	EGF-like 1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CTGTGCCTCCGGCCCCTGCCT	0.662000													9	59					0	0	0.058154	0	0
HERC1	8925	broad.mit.edu	37	15	63942010	63942010	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:63942010C>T	ENST00000443617.2	-	54	10748	c.10661G>A	c.(10660-10662)cGg>cAg	p.R3554Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3554					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TCCATCCATCCGTCCCACCAA	0.512000													7	23					0	0	0.029380	0	0
TENM2	57451	broad.mit.edu	37	5	167689098	167689098	+	Silent	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:167689098C>G	ENST00000519204.1	+	28	7363	c.7245C>G	c.(7243-7245)gcC>gcG	p.A2415A	TENM2_ENST00000545108.1_Silent_p.A2535A|TENM2_ENST00000518659.1_Silent_p.A2536A|TENM2_ENST00000403607.2_Silent_p.A2360A|TENM2_ENST00000520394.1_Silent_p.A2297A					teneurin transmembrane protein 2																		ATAACCAGGCCTTCATGGCTC	0.507000													6	42					0	0	0.021553	0	0
TMEM37	140738	broad.mit.edu	37	2	120194495	120194495	+	Missense_Mutation	SNP	C	C	T	rs141678483		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:120194495C>T	ENST00000306406.4	+	2	87	c.52C>T	c.(52-54)Cgc>Tgc	p.R18C	TMEM37_ENST00000465296.1_3'UTR|TMEM37_ENST00000409826.1_Missense_Mutation_p.R30C	NM_183240.2	NP_899063.2	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	18						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						AAGGCAGCCCCGCCGGTCCTT	0.612000													12	73					0	0	0.093190	0	0
DAPK1	1612	broad.mit.edu	37	9	90321943	90321943	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:90321943G>A	ENST00000469640.2	+	27	4407	c.4032G>A	c.(4030-4032)ccG>ccA	p.P1344P	DAPK1_ENST00000472284.1_Silent_p.P1319P|DAPK1_ENST00000358077.5_Silent_p.P1319P|DAPK1_ENST00000408954.3_Silent_p.P1319P|DAPK1_ENST00000491893.1_Silent_p.P1253P			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1319	Death.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TGCTGGACCCGCCCGACCCCC	0.602000									Chronic Lymphocytic Leukemia, Familial Clustering of				9	106					0	0	0.047766	0	0
NID1	4811	broad.mit.edu	37	1	236175241	236175241	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:236175241C>T	ENST00000264187.6	-	12	2589	c.2507G>A	c.(2506-2508)gGc>gAc	p.G836D	NID1_ENST00000366595.3_Intron	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	836	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCAACGGAAGCCGTCTCCCTG	0.577000													8	89					0	0	0.047766	0	0
CACNA1A	773	broad.mit.edu	37	19	13414687	13414687	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:13414687G>A	ENST00000360228.5	-	16	1997	c.1998C>T	c.(1996-1998)ggC>ggT	p.G666G	CACNA1A_ENST00000573710.2_Silent_p.G667G	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	667			T -> M (in FHM1 and EA2; dbSNP:rs121908212).		cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCAGTCTTCGCCCGTCAGGA	0.592000													18	159					0	0	0.038395	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	64					0	0	0.014758	0	0
COL1A2	1278	broad.mit.edu	37	7	94051241	94051241	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:94051241C>T	ENST00000297268.6	+	39	2851	c.2380C>T	c.(2380-2382)Cgg>Tgg	p.R794W		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	794			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGCTGCTGGACGGACTGGTCC	0.458000										HNSCC(75;0.22)			6	57					0	0	0.029380	0	0
XPO7	23039	broad.mit.edu	37	8	21843104	21843104	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:21843104G>A	ENST00000434536.1	+	13	1608	c.1506G>A	c.(1504-1506)ctG>ctA	p.L502L	XPO7_ENST00000252512.9_Silent_p.L493L|XPO7_ENST00000433566.4_Silent_p.L494L			Q9UIA9	XPO7_HUMAN	exportin 7	493					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CAGGAAGGCTGACATGGCTGG	0.498000													40	139					0	0	0.104719	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38414183	38414183	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:38414183G>A	ENST00000377694.1	-	2	500	c.478C>T	c.(478-480)Cct>Tct	p.P160S		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	160	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CTTCGGGGAGGAACGACGACC	0.592000													6	83					0	0	0.021553	0	0
PLIN3	10226	broad.mit.edu	37	19	4847853	4847853	+	Silent	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:4847853C>T	ENST00000221957.4	-	6	860	c.684G>A	c.(682-684)caG>caA	p.Q228Q	PLIN3_ENST00000585479.1_Silent_p.Q228Q|PLIN3_ENST00000592528.1_Silent_p.Q216Q	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	228					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	CCTGCCGCTGCTGCTGCACGG	0.617000													3	23					0	0	0.021553	0	0
AGAP1	116987	broad.mit.edu	37	2	237032621	237032621	+	Missense_Mutation	SNP	G	G	A	rs150891900		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:237032621G>A	ENST00000409538.1	+	17	3561	c.3065G>A	c.(3064-3066)cGg>cAg	p.R1022Q	AGAP1_ENST00000428334.2_Missense_Mutation_p.R649Q|AGAP1_ENST00000304032.7_Missense_Mutation_p.R810Q|AGAP1_ENST00000336665.5_Missense_Mutation_p.R757Q			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	810					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GCCTACGCCCGGCAGGCCTCC	0.637000													6	71					0	0	0.021553	0	0
FNBP1	23048	broad.mit.edu	37	9	132740854	132740854	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:132740854C>T	ENST00000420781.1	-	4	453	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	FNBP1_ENST00000355681.3_Missense_Mutation_p.E79K|FNBP1_ENST00000446176.2_Missense_Mutation_p.E79K			Q96RU3	FNBP1_HUMAN	formin binding protein 1	79	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding	p.E79K(1)					Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		TCATTCATTTCGTTCAGGTTG	0.433000			T	MLL	AML								7	50					0	0	0.038147	0	0
PRMT7	54496	broad.mit.edu	37	16	68382250	68382250	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:68382250C>G	ENST00000339507.5	+	14	2159	c.1329C>G	c.(1327-1329)ttC>ttG	p.F443L	PRMT7_ENST00000441236.1_Missense_Mutation_p.F393L|PRMT7_ENST00000348497.4_Intron|PRMT7_ENST00000449359.3_Missense_Mutation_p.F393L			Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	443					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|urinary_tract(1)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CTAAGATCTTCAAGGCTAACC	0.373000													8	84					0	0	0.058154	0	0
EMC1	23065	broad.mit.edu	37	1	19577911	19577911	+	Silent	SNP	A	A	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:19577911A>G	ENST00000477853.1	-	1	135	c.93T>C	c.(91-93)gaT>gaC	p.D31D	EMC1_ENST00000356068.2_Silent_p.D31D|EMC1_ENST00000375199.3_Silent_p.D31D|EMC1_ENST00000375208.3_Silent_p.D31D	NM_001271428.1|NM_015047.1	NP_001258357.1|NP_055862.1			ER membrane protein complex subunit 1																		GTACGCACCAATCAAACTTGC	0.537000													9	48					0	0	0.058154	0	0
ATCAY	85300	broad.mit.edu	37	19	3920766	3920766	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:3920766C>G	ENST00000450849.2	+	12	1543	c.1076C>G	c.(1075-1077)tCt>tGt	p.S359C	ATCAY_ENST00000600960.1_Missense_Mutation_p.S359C|ATCAY_ENST00000398448.3_Missense_Mutation_p.S365C|ATCAY_ENST00000301260.6_Missense_Mutation_p.S359C	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	359					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CTCCACAGGTCTGCTCTGGTC	0.418000													4	34					0	0	0.014758	0	0
RHBDL1	9028	broad.mit.edu	37	16	727019	727019	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:727019C>A	ENST00000219551.2	+	3	697	c.670C>A	c.(670-672)Cag>Aag	p.Q224K	RHBDL1_ENST00000352681.3_Missense_Mutation_p.Q159K			O75783	RHBL1_HUMAN	rhomboid, veinlet-like 1 (Drosophila)	224					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|lung(4)|urinary_tract(3)	9		Hepatocellular(780;0.0218)				GTGGGTGCTGCAGACCTACCA	0.637000													8	62					0.00307968	0.00318497	0.038147	1	0
TRAPPC9	83696	broad.mit.edu	37	8	140744267	140744267	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:140744267G>A	ENST00000389328.4	-	22	3542	c.3528C>T	c.(3526-3528)caC>caT	p.H1176H	TRAPPC9_ENST00000522504.1_5'UTR|TRAPPC9_ENST00000438773.2_Silent_p.H1078H|TRAPPC9_ENST00000389327.3_Silent_p.H1069H	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	1078					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						AGACGGTGTCGTGCAGGTCGT	0.657000													5	11					0	0	0.021553	0	0
UBR5	51366	broad.mit.edu	37	8	103305835	103305835	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:103305835G>A	ENST00000520539.1	-	34	5193	c.4587C>T	c.(4585-4587)agC>agT	p.S1529S	UBR5_ENST00000521922.1_Silent_p.S1523S|UBR5_ENST00000519528.1_5'UTR|UBR5_ENST00000220959.4_Silent_p.S1529S	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1529	Poly-Ser.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CAATTTACCTGCTAGACTGAT	0.433000													11	99					0	0	0.119110	0	0
OR6M1	390261	broad.mit.edu	37	11	123676267	123676267	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:123676267G>A	ENST00000309154.2	-	1	828	c.791C>T	c.(790-792)tCa>tTa	p.S264L		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		ATAATCCAGTGAGGAGTTCTG	0.488000													8	66					0	0	0.047766	0	0
DOCK2	1794	broad.mit.edu	37	5	169477279	169477279	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:169477279G>A	ENST00000256935.8	+	41	4171	c.4091G>A	c.(4090-4092)cGc>cAc	p.R1364H	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.R856H|DOCK2_ENST00000540750.1_Missense_Mutation_p.R425H	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1364	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCATCTACCGCGGGAAGGAA	0.502000													19	175					0	0	0.049695	0	0
PKP4	8502	broad.mit.edu	37	2	159535144	159535144	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:159535144G>C	ENST00000389757.3	+	20	3304	c.3179G>C	c.(3178-3180)aGa>aCa	p.R1060T	AC005042.4_ENST00000342892.4_RNA|PKP4_ENST00000389759.3_Missense_Mutation_p.R1103T	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	1103					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						TCACCAGCAAGAGAACAAAAT	0.383000										HNSCC(62;0.18)			18	71					0	0	0.049695	0	0
PRB3	5544	broad.mit.edu	37	12	11420826	11420826	+	RNA	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:11420826C>A	ENST00000381842.3	-	0	394				PRB3_ENST00000279573.6_RNA|PRB3_ENST00000440870.3_RNA|PRB3_ENST00000538488.1_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GTCCTTCTGGCTTTCCCGGAC	0.632000													18	195					5.77227e-19	6.40775e-19	0.134883	1	0
TMOD1	7111	broad.mit.edu	37	9	100331211	100331211	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:100331211G>A	ENST00000395211.2	+	8	898	c.762G>A	c.(760-762)ttG>ttA	p.L254L	TMOD1_ENST00000259365.3_Silent_p.L254L|TMOD1_ENST00000375175.1_Silent_p.L127L	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	254					muscle filament sliding	cytosol	actin binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		ACAAGGTGTTGAAGACACTGA	0.507000													13	107					0	0	0.119110	0	0
EPPK1	83481	broad.mit.edu	37	8	144940690	144940690	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:144940690G>A	ENST00000525985.1	-	2	6803	c.6732C>T	c.(6730-6732)agC>agT	p.S2244S				P58107	EPIPL_HUMAN	epiplakin 1	2244						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTGGTAGATGCTCATCTTCT	0.711000													7	102					0	0	0.047766	0	0
PUS7L	83448	broad.mit.edu	37	12	44148576	44148576	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:44148576G>A	ENST00000416848.2	-	2	961	c.473C>T	c.(472-474)cCt>cTt	p.P158L	PUS7L_ENST00000551923.1_Missense_Mutation_p.P158L|PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000553166.1_Missense_Mutation_p.P158L|PUS7L_ENST00000344862.5_Missense_Mutation_p.P158L	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	158					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		GAATTCAGGAGGTAGTCCAAT	0.368000													10	120					0	0	0.093190	0	0
FAM107A	11170	broad.mit.edu	37	3	58555543	58555543	+	Silent	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:58555543C>G	ENST00000394481.1	-	3	603	c.45G>C	c.(43-45)ctG>ctC	p.L15L	FAM107A_ENST00000360997.2_Silent_p.L15L|FAM107A_ENST00000447756.2_Silent_p.L43L|FAM107A_ENST00000464064.1_Silent_p.L15L|FAM107A_ENST00000474531.1_Silent_p.L46L	NM_007177.2	NP_009108.1	O95990	F107A_HUMAN	family with sequence similarity 107, member A	15			L -> M (in ovarian cancer and renal cell carcinoma cell lines).		regulation of cell growth	nucleus	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(55;0.000189)|Kidney(10;0.000536)|KIRC - Kidney renal clear cell carcinoma(10;0.000716)|OV - Ovarian serous cystadenocarcinoma(275;0.154)		GCCGGGCCATCAGGCCCCCAA	0.597000													12	95					0	0	0.093190	0	0
CACNA1B	774	broad.mit.edu	37	9	141016410	141016410	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:141016410C>T	ENST00000277549.5	+	47	7130	c.4561C>T	c.(4561-4563)Cgg>Tgg	p.R1521W	CACNA1B_ENST00000371363.1_Missense_Mutation_p.R2325W|CACNA1B_ENST00000371372.1_Missense_Mutation_p.R2327W|CACNA1B_ENST00000371355.4_Missense_Mutation_p.R2328W|CACNA1B_ENST00000277551.2_3'UTR|CACNA1B_ENST00000371357.1_Missense_Mutation_p.R2326W			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	2327					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGGCCGAGCACGGCACAGCTA	0.637000													9	39					0	0	0.047766	0	0
SORCS2	57537	broad.mit.edu	37	4	7726911	7726911	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:7726911T>C	ENST00000507866.2	+	20	2751	c.2642T>C	c.(2641-2643)gTt>gCt	p.V881A	SORCS2_ENST00000329016.9_Missense_Mutation_p.V709A	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	881						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						CTGGAGGTGGTTCCTGTCATT	0.577000													18	61					0	0	0.038395	0	0
DDX4	54514	broad.mit.edu	37	5	55082475	55082475	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:55082475G>A	ENST00000505374.1	+	14	1086	c.994G>A	c.(994-996)Gct>Act	p.A332T	DDX4_ENST00000511853.1_Missense_Mutation_p.A183T|DDX4_ENST00000354991.5_Missense_Mutation_p.A298T|DDX4_ENST00000514278.2_Missense_Mutation_p.A312T|DDX4_ENST00000353507.5_Missense_Mutation_p.A298T	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	332	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GATGGCTTGCGCTCAAACAGG	0.398000													8	136					0	0	0.069234	0	0
CD72	971	broad.mit.edu	37	9	35618375	35618375	+	Translation_Start_Site	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:35618375G>A	ENST00000396757.1	-	0	90				CD72_ENST00000259633.4_De_novo_Start_OutOfFrame|CD72_ENST00000378430.3_De_novo_Start_OutOfFrame|CD72_ENST00000490239.1_5'UTR			P21854	CD72_HUMAN	CD72 molecule						axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity			large_intestine(5)|liver(1)|lung(6)	12			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTCTCTGTCCGTTTACAACTA	0.547000													5	21					0	0	0.014758	0	0
CASP8	841	broad.mit.edu	37	2	202149644	202149644	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:202149644A>G	ENST00000358485.4	+	8	1281	c.1085A>G	c.(1084-1086)gAc>gGc	p.D362G	CASP8_ENST00000264274.9_Missense_Mutation_p.D219G|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000432109.2_Missense_Mutation_p.D303G|CASP8_ENST00000264275.5_Missense_Mutation_p.D320G|CASP8_ENST00000323492.7_Missense_Mutation_p.D288G	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	303					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						CAACTCATGGACCACAGTAAC	0.473000										HNSCC(4;0.00038)			30	136					0	0	0.116897	0	0
SCLT1	132320	broad.mit.edu	37	4	129873944	129873944	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:129873944C>A	ENST00000281142.5	-	14	1701	c.1198G>T	c.(1198-1200)Gaa>Taa	p.E400*	SCLT1_ENST00000503215.1_Intron|SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000439369.2_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	400						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						GCTGAAAGTTCTTCTGTTAAT	0.279000													8	90					0.000157383	0.000167047	0.038147	1	0
ZNF362	149076	broad.mit.edu	37	1	33745847	33745847	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:33745847G>A	ENST00000539719.1	+	5	642	c.472G>A	c.(472-474)Gcc>Acc	p.A158T	ZNF362_ENST00000373428.5_Missense_Mutation_p.A158T	NM_152493.2	NP_689706.2	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCGCCTCATCGCCTCGTCCCC	0.682000													8	124					0	0	0.047766	0	0
FSIP1	161835	broad.mit.edu	37	15	40068654	40068654	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:40068654G>T	ENST00000350221.3	-	2	281	c.72C>A	c.(70-72)agC>agA	p.S24R	RP11-37C7.1_ENST00000558616.1_RNA	NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	24										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TTGAACTTCTGCTCCCAGGGC	0.368000													10	146					4.68919e-08	5.11164e-08	0.069234	1	0
ANKRD12	23253	broad.mit.edu	37	18	9255584	9255584	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:9255584G>C	ENST00000383440.2	+	8	2507	c.2250G>C	c.(2248-2250)gaG>gaC	p.E750D	ANKRD12_ENST00000400020.3_Missense_Mutation_p.E750D|ANKRD12_ENST00000262126.3_Missense_Mutation_p.E773D	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	773						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						TAAAAGAAGAGAGAGAAAACA	0.348000													7	64					0	0	0.029380	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57867440	57867440	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:57867440G>C	ENST00000393797.2	-	20	2432	c.2240C>G	c.(2239-2241)tCa>tGa	p.S747*	ARHGAP9_ENST00000393791.3_Nonsense_Mutation_p.S657*|ARHGAP9_ENST00000424809.2_Intron|ARHGAP9_ENST00000430041.2_Nonsense_Mutation_p.S473*|ARHGAP9_ENST00000356411.2_Nonsense_Mutation_p.S676*|ARHGAP9_ENST00000550288.1_Silent_p.L730L			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	676	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			CTTTGGCATTGAGCCTATTAA	0.488000													10	92					0	0	0.069234	0	0
DDX10	1662	broad.mit.edu	37	11	108546344	108546344	+	Missense_Mutation	SNP	G	G	A	rs145766863	byFrequency	TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:108546344G>A	ENST00000526794.1	+	3	301	c.269G>A	c.(268-270)cGt>cAt	p.R90H	DDX10_ENST00000322536.3_Missense_Mutation_p.R90H			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	90							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GCTCAGTACCGTTTGGTGACT	0.458000			T	NUP98	AML*								8	92					0	0	0.047766	0	0
MYO3A	53904	broad.mit.edu	37	10	26463239	26463239	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:26463239C>A	ENST00000265944.5	+	30	4212	c.4046C>A	c.(4045-4047)gCa>gAa	p.A1349E	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1349	IQ 3.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GAAGATAAAGCAGCGGTATTC	0.488000													11	89					0.00829132	0.00850211	0.069234	1	0
CTCF	10664	broad.mit.edu	37	16	67650717	67650717	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:67650717G>A	ENST00000264010.4	+	5	1466	c.1022G>A	c.(1021-1023)cGt>cAt	p.R341H	CTCF_ENST00000401394.1_Missense_Mutation_p.R13H	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	341					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GTTCGGCATCGTCGTTACAAA	0.488000													26	276					0	0	0.108266	0	0
FAT1	2195	broad.mit.edu	37	4	187541184	187541184	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:187541184A>C	ENST00000441802.2	-	10	6765	c.6556T>G	c.(6556-6558)Ttc>Gtc	p.F2186V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2186	Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCACTGTAGAAAGGTTTTTCA	0.507000										HNSCC(5;0.00058)			6	75					0	0	0.021553	0	0
HNRNPM	4670	broad.mit.edu	37	19	8551952	8551952	+	Silent	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:8551952C>T	ENST00000348943.3	+	16	2137	c.1905C>T	c.(1903-1905)aaC>aaT	p.N635N	HNRNPM_ENST00000325495.4_Silent_p.N674N	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	674					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						ACAAATTCAACGAGTGCGGTA	0.517000													18	142					0	0	0.038395	0	0
STAT5B	6777	broad.mit.edu	37	17	40359614	40359614	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:40359614G>A	ENST00000293328.3	-	16	2207	c.2039C>T	c.(2038-2040)tCc>tTc	p.S680F		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	680	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GTAGTATTTGGAGTATACTTC	0.463000													18	145					0	0	0.043863	0	0
DBT	1629	broad.mit.edu	37	1	100672165	100672165	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:100672165C>G	ENST00000370132.3	-	9	1058	c.1045G>C	c.(1045-1047)Gat>Cat	p.D349H		NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2	349					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TGCTCAGTATCCATTGCTATC	0.388000													33	252					0	0	0.080422	0	0
SCLT1	132320	broad.mit.edu	37	4	129864211	129864211	+	Silent	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:129864211C>T	ENST00000281142.5	-	17	2075	c.1572G>A	c.(1570-1572)cgG>cgA	p.R524R	SCLT1_ENST00000503215.1_Intron|SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000439369.2_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	524						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						CAGTCTCTTTCCGTAACTGTT	0.363000													8	92					0	0	0.047766	0	0
CACNA1E	777	broad.mit.edu	37	1	181702070	181702070	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:181702070G>T	ENST00000526775.1	+	19	2956	c.2791G>T	c.(2791-2793)Gaa>Taa	p.E931*	CACNA1E_ENST00000367573.2_Nonsense_Mutation_p.E950*|CACNA1E_ENST00000360108.3_Nonsense_Mutation_p.E931*|CACNA1E_ENST00000367567.4_Nonsense_Mutation_p.E557*|CACNA1E_ENST00000358338.5_Nonsense_Mutation_p.E882*|CACNA1E_ENST00000367570.1_Nonsense_Mutation_p.E950*|CACNA1E_ENST00000357570.5_Nonsense_Mutation_p.E901*	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	950					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CAGTCTGGATGAAGCCATGCC	0.612000													12	99					1.61879e-10	1.78067e-10	0.093190	1	0
IQUB	154865	broad.mit.edu	37	7	123142651	123142651	+	Splice_Site	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:123142651C>T	ENST00000466202.1	-	6	1599	c.1023_splice	c.e6+1	p.A341_splice	IQUB_ENST00000434450.1_Splice_Site_p.A341_splice|IQUB_ENST00000324698.6_Splice_Site_p.A341_splice|IQUB_ENST00000488987.1_5'UTR			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	341	IQ.									breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						GTTATCTCACCGCCTTTAGTC	0.358000													6	71					0	0	0.038147	0	0
MFN1	55669	broad.mit.edu	37	3	179076745	179076745	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:179076745A>C	ENST00000471841.1	+	4	492	c.366A>C	c.(364-366)aaA>aaC	p.K122N	MFN1_ENST00000280653.7_Missense_Mutation_p.K122N|MFN1_ENST00000263969.5_Missense_Mutation_p.K122N	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	122					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ATGGAGATAAAGCCTATCTTA	0.373000													10	79					0	0	0.069234	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43984289	43984289	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:43984289C>T	ENST00000282406.4	+	26	3937	c.3827C>T	c.(3826-3828)tCa>tTa	p.S1276L		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1276	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGACCTTTCTCAACTCCAGCA	0.333000													6	84					0	0	0.021553	0	0
TRIM71	131405	broad.mit.edu	37	3	32933083	32933083	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:32933083G>A	ENST00000383763.4	+	4	2450	c.2387G>A	c.(2386-2388)cGc>cAc	p.R796H		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	796					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAGTTCCTGCGCCCACAAGGG	0.592000													9	74					0	0	0.047766	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67318871	67318871	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:67318871C>A	ENST00000360461.5	+	12	4483	c.1948C>A	c.(1948-1950)Cca>Aca	p.P650T	PLEKHG4_ENST00000427155.2_Missense_Mutation_p.P650T|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.P650T|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.P569T	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	650					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		ACTGAAGCTACCACCGGTGGG	0.667000													6	28					0.00198382	0.00206933	0.029380	1	0
ZNF407	55628	broad.mit.edu	37	18	72344099	72344099	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:72344099C>A	ENST00000299687.5	+	1	1124	c.1124C>A	c.(1123-1125)cCt>cAt	p.P375H	ZNF407_ENST00000582337.1_Missense_Mutation_p.P375H|ZNF407_ENST00000309902.6_Missense_Mutation_p.P375H|ZNF407_ENST00000577538.1_Missense_Mutation_p.P375H	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	375					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GCTCAGAATCCTGAAAACCAG	0.413000													6	82					0.000157383	0.000167047	0.038147	1	0
GPR116	221395	broad.mit.edu	37	6	46847692	46847692	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr6:46847692G>A	ENST00000283296.7	-	9	1187	c.899C>T	c.(898-900)tCc>tTc	p.S300F	GPR116_ENST00000265417.7_Missense_Mutation_p.S300F|GPR116_ENST00000362015.4_Missense_Mutation_p.S300F|GPR116_ENST00000456426.2_Intron	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	300	Ig-like 1.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AGACACATTGGAGGACAAAAC	0.438000													9	80					0	0	0.058154	0	0
ATP9A	10079	broad.mit.edu	37	20	50255990	50255990	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr20:50255990G>C	ENST00000338821.5	-	15	1824	c.1560C>G	c.(1558-1560)gaC>gaG	p.D520E	ATP9A_ENST00000402822.1_Missense_Mutation_p.D399E|ATP9A_ENST00000311637.5_Missense_Mutation_p.D384E	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	520					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGGAAGACTGGTCTCGGCCCA	0.542000											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	89					0	0	0.029380	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580618	50580618	+	Splice_Site	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr22:50580618G>A	ENST00000262794.5	+	16	2262	c.2179_splice	c.e16+1	p.V727_splice	MOV10L1_ENST00000540615.1_Splice_Site_p.V707_splice|MOV10L1_ENST00000545383.1_Splice_Site_p.V727_splice|MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Splice_Site_p.V727_splice	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	727					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GAGCGATTGGGGTATGTGCTC	0.547000											OREG0026672	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	36					0	0	0.038147	0	0
PSMB4	5692	broad.mit.edu	37	1	151373293	151373293	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:151373293C>T	ENST00000290541.6	+	4	602	c.548C>T	c.(547-549)gCc>gTc	p.A183V		NM_002796.2	NP_002787.2	P28070	PSB4_HUMAN	proteasome (prosome, macropain) subunit, beta type, 4	183					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|lung(9)|ovary(2)|prostate(1)|skin(1)	14	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTTCGCTGGCCACTGGTTAT	0.463000													35	302					0	0	0.086207	0	0
IGLV3-19	28797	broad.mit.edu	37	22	23063594	23063594	+	RNA	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr22:23063594G>A	ENST00000390309.2	+	0	341																											GGCGGAAGATGAGGCTGACTA	0.527000													9	32					0	0	0.058154	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99117510	99117510	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:99117510C>A	ENST00000394170.2	+	4	865	c.614C>A	c.(613-615)tCa>tAa	p.S205*	ZKSCAN5_ENST00000451158.1_Nonsense_Mutation_p.S205*|ZKSCAN5_ENST00000326775.5_Nonsense_Mutation_p.S205*	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	205					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGACAGCTTCACTTCTCTCA	0.517000													11	69					2.27111e-07	2.45361e-07	0.093190	1	0
SKOR1	390598	broad.mit.edu	37	15	68118861	68118861	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:68118861C>T	ENST00000380035.2	+	2	753	c.695C>T	c.(694-696)gCc>gTc	p.A232V	SKOR1_ENST00000389002.1_Missense_Mutation_p.A223V|SKOR1_ENST00000341418.5_Missense_Mutation_p.A418V|SKOR1_ENST00000554054.1_Missense_Mutation_p.A204V|SKOR1_ENST00000554240.1_Missense_Mutation_p.A193V			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	232					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						ACACCCGACGCCAAGTACACG	0.567000													7	57					0	0	0.038147	0	0
SEC23IP	11196	broad.mit.edu	37	10	121685734	121685734	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:121685734G>A	ENST00000369075.3	+	13	2380	c.2308G>A	c.(2308-2310)Gga>Aga	p.G770R	SEC23IP_ENST00000543134.1_Missense_Mutation_p.G559R	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	770					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding	p.G770R(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		AGTTGGCGCCGGACAGGTGAG	0.393000													19	137					0	0	0.049695	0	0
CD1E	913	broad.mit.edu	37	1	158325848	158325848	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:158325848G>A	ENST00000444681.2	+	3	853	c.560G>A	c.(559-561)cGg>cAg	p.R187Q	CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368163.3_Intron|CD1E_ENST00000368156.1_Missense_Mutation_p.R196Q|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.R286Q|CD1E_ENST00000368161.3_Intron|CD1E_ENST00000452291.2_Missense_Mutation_p.R97Q|CD1E_ENST00000368165.3_Missense_Mutation_p.R196Q|CD1E_ENST00000368160.3_Missense_Mutation_p.R286Q|CD1E_ENST00000368166.3_Missense_Mutation_p.R97Q|CD1E_ENST00000434258.1_Missense_Mutation_p.R284Q	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	286					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					CTGTCCTGTCGGGTGAAACAC	0.572000													15	97					0	0	0.146539	0	0
FOCAD	54914	broad.mit.edu	37	9	20789459	20789459	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:20789459C>T	ENST00000380249.1	+	13	1671	c.1307C>T	c.(1306-1308)gCt>gTt	p.A436V	FOCAD_ENST00000338382.6_Missense_Mutation_p.A436V	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	436						integral to membrane	binding										GACTGGTTGGCTTCAGTAGAG	0.463000													11	84					0	0	0.069234	0	0
MROH2B	133558	broad.mit.edu	37	5	41008749	41008749	+	Silent	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:41008749C>T	ENST00000399564.4	-	33	4017	c.3567G>A	c.(3565-3567)gtG>gtA	p.V1189V	MROH2B_ENST00000506092.2_Silent_p.V744V	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CCTGCTGCATCACATGCCGCC	0.567000													5	39					0	0	0.021553	0	0
SEMA3E	9723	broad.mit.edu	37	7	83014672	83014672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:83014672G>A	ENST00000307792.3	-	16	2280	c.1813C>T	c.(1813-1815)Cga>Tga	p.R605*	SEMA3E_ENST00000427262.1_Nonsense_Mutation_p.R545*	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	605	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TGTAAAGATCGTGGGGTACAT	0.398000													20	132					0	0	0.049695	0	0
PRUNE2	158471	broad.mit.edu	37	9	79465512	79465512	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:79465512C>T	ENST00000376718.3	-	3	334	c.211G>A	c.(211-213)Gag>Aag	p.E71K	PRUNE2_ENST00000428286.1_5'UTR|PRUNE2_ENST00000376713.3_Missense_Mutation_p.E71K	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	71					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AACCTCGTCTCGGTGAAGTAG	0.393000													16	151					0	0	0.038395	0	0
TRAPPC6A	79090	broad.mit.edu	37	19	45681407	45681407	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:45681407C>G	ENST00000006275.4	-	1	88	c.70G>C	c.(70-72)Gac>Cac	p.D24H	TRAPPC6A_ENST00000592647.1_Missense_Mutation_p.D24H|TRAPPC6A_ENST00000588062.1_Missense_Mutation_p.D24H|TRAPPC6A_ENST00000585934.1_Missense_Mutation_p.D24H	NM_024108.1	NP_077013.1	O75865	TPC6A_HUMAN	trafficking protein particle complex 6A	24					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	8		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00872)|GBM - Glioblastoma multiforme(486;0.233)		GGGCCGGGGTCGGGGTCGTGA	0.682000													5	43					0	0	0.014758	0	0
EZH1	2145	broad.mit.edu	37	17	40854917	40854917	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:40854917C>T	ENST00000428826.2	-	20	2282	c.2161G>A	c.(2161-2163)Gaa>Aaa	p.E721K	EZH1_ENST00000585893.1_Missense_Mutation_p.E681K|EZH1_ENST00000592743.1_Missense_Mutation_p.E721K|EZH1_ENST00000590078.1_Missense_Mutation_p.E651K|EZH1_ENST00000435174.1_Missense_Mutation_p.E582K|EZH1_ENST00000415827.2_Missense_Mutation_p.E712K			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	721	SET.			VVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGI ERETDVL -> GESQ (in Ref. 2; BAA25019).	anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding	p.E721K(1)		breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		AAGAGCTCTTCGCCAGCTTGA	0.512000													20	196					0	0	0.069288	0	0
NLRP5	126206	broad.mit.edu	37	19	56539838	56539838	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:56539838G>C	ENST00000390649.3	+	7	2239	c.2239G>C	c.(2239-2241)Gat>Cat	p.D747H		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	747						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTTCCCAAGAGATGAGTCCGC	0.517000													20	209					0	0	0.055883	0	0
MYH4	4622	broad.mit.edu	37	17	10354168	10354168	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:10354168G>A	ENST00000255381.2	-	29	4020	c.3910C>T	c.(3910-3912)Cag>Tag	p.Q1304*	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1304					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CGGGATAGCTGAGAAACCATA	0.383000													20	110					0	0	0.062417	0	0
HK3	3101	broad.mit.edu	37	5	176314244	176314244	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:176314244G>C	ENST00000292432.5	-	12	1786	c.1695C>G	c.(1693-1695)atC>atG	p.I565M		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	565	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAATGGAGTAGATCTCGCTGG	0.622000													11	55					0	0	0.069234	0	0
DSEL	92126	broad.mit.edu	37	18	65178325	65178325	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:65178325A>G	ENST00000310045.7	-	2	5024	c.3551T>C	c.(3550-3552)aTa>aCa	p.I1184T	CTD-2541J13.2_ENST00000583493.1_RNA|CTD-2541J13.2_ENST00000581951.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1174						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AGTTGGTGATATTTCCCCTTC	0.363000													10	66					0	0	0.058154	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43650731	43650731	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:43650731C>T	ENST00000374466.3	+	2	469	c.134C>T	c.(133-135)cCt>cTt	p.P45L	CSGALNACT2_ENST00000374464.1_Missense_Mutation_p.P45L	NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	45					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GCATCTCTTCCTGGTGTTGTT	0.463000													8	64					0	0	0.047766	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648571	62648571	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:62648571G>A	ENST00000337910.5	-	6	1192	c.855C>T	c.(853-855)ctC>ctT	p.L285L	RHOBTB1_ENST00000357917.4_Silent_p.L285L	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	285	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AAGAGGTAGCGAGGTAAATTC	0.438000													13	92					0	0	0.105934	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187969	37187969	+	RNA	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:37187969C>T	ENST00000425901.2	+	0	1811					NR_033753.2																						TCCAGAGCTACGTAAGGAGGT	0.493000													6	34					0	0	0.021553	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57867414	57867414	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:57867414G>C	ENST00000393797.2	-	20	2458	c.2266C>G	c.(2266-2268)Cta>Gta	p.L756V	ARHGAP9_ENST00000393791.3_Missense_Mutation_p.L666V|ARHGAP9_ENST00000424809.2_Intron|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.L482V|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.L685V|ARHGAP9_ENST00000550288.1_3'UTR			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	685					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			AGGTACCGTAGAGTGTCATGG	0.507000													12	109					0	0	0.093190	0	0
CMYA5	202333	broad.mit.edu	37	5	79030604	79030604	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:79030604G>C	ENST00000446378.2	+	2	6047	c.6016G>C	c.(6016-6018)Gag>Cag	p.E2006Q		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2006						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAACATAGCAGAGGGGAAGGA	0.408000													5	45					0	0	0.014758	0	0
TMOD1	7111	broad.mit.edu	37	9	100331220	100331220	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:100331220G>A	ENST00000395211.2	+	8	907	c.771G>A	c.(769-771)ctG>ctA	p.L257L	TMOD1_ENST00000259365.3_Silent_p.L257L|TMOD1_ENST00000375175.1_Silent_p.L130L	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	257					muscle filament sliding	cytosol	actin binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		TGAAGACACTGAATGTGGAAT	0.498000													15	102					0	0	0.119110	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799485	140799485	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:140799485G>A	ENST00000398594.2	+	1	2059	c.2059G>A	c.(2059-2061)Gag>Aag	p.E687K	PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCAGGCTGAGATGCAGTT	0.552000													8	72					0	0	0.038147	0	0
HRAS	3265	broad.mit.edu	37	11	534289	534289	+	Missense_Mutation	SNP	C	C	T	rs104894229		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:534289C>T	ENST00000417302.1	-	2	221	c.34G>A	c.(34-36)Ggc>Agc	p.G12S	HRAS_ENST00000397596.2_Missense_Mutation_p.G12S|HRAS_ENST00000451590.1_Missense_Mutation_p.G12S|HRAS_ENST00000397594.1_Missense_Mutation_p.G12S|HRAS_ENST00000311189.7_Missense_Mutation_p.G12S|HRAS_ENST00000468682.2_5'UTR	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	12			G -> A (in FCSS).|G -> C (in FCSS).|G -> E (in FCSS).|G -> S (in FCSS, OSCC and CMEMS).|G -> V (in FCSS, bladder carcinoma and CMEMS; constitutively activated; interacts and recruits PLCE1 to plasma membrane; loss of interaction with and recruitment to plasma membrane of PLCE1 when associated with F-32; loss of interaction with PLCE1 when associated with G-26, F-32 and S-35; no effect on interaction with PLCE1 when associated with A-29, G-34, G-37, N-38 and C-39; no effect on subcellular location of isoform 2).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12S(58)|p.G12C(25)|p.G12R(12)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCCACACCGCCGGCGCCCACC	0.647000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			56	46					0	0	0.139131	0	0
SLX4IP	128710	broad.mit.edu	37	20	10604013	10604013	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr20:10604013G>A	ENST00000334534.5	+	8	1393	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K		NM_001009608.1	NP_001009608.1			SLX4 interacting protein									p.E405*(1)									AAAGAAATACGAAAGAGGCCA	0.448000													6	63					0	0	0.021553	0	0
RHBDL1	9028	broad.mit.edu	37	16	727018	727018	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:727018G>A	ENST00000219551.2	+	3	696	c.669G>A	c.(667-669)ctG>ctA	p.L223L	RHBDL1_ENST00000352681.3_Silent_p.L158L			O75783	RHBL1_HUMAN	rhomboid, veinlet-like 1 (Drosophila)	223					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|lung(4)|urinary_tract(3)	9		Hepatocellular(780;0.0218)				AGTGGGTGCTGCAGACCTACC	0.637000													8	63					0	0	0.038147	0	0
CCDC28A	25901	broad.mit.edu	37	6	139101031	139101031	+	Silent	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr6:139101031C>T	ENST00000332797.6	+	3	656	c.501C>T	c.(499-501)tcC>tcT	p.S167S		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	167										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TCCAGCACTCCTTCCTCACTG	0.453000													10	82					0	0	0.080935	0	0
FAM3D	131177	broad.mit.edu	37	3	58639409	58639409	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:58639409C>T	ENST00000358781.2	-	3	423	c.113G>A	c.(112-114)cGc>cAc	p.R38H		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	38					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		ACCCAGCCAGCGTGGCAGACG	0.577000													13	148					0	0	0.033300	0	0
C1orf101	257044	broad.mit.edu	37	1	244735832	244735832	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:244735832C>G	ENST00000366534.4	+	11	1762	c.1708C>G	c.(1708-1710)Ctg>Gtg	p.L570V	C1orf101_ENST00000366533.4_Missense_Mutation_p.L570V|C1orf101_ENST00000366531.3_Missense_Mutation_p.L419V|C1orf101_ENST00000473875.1_3'UTR	NM_001130957.1	NP_001124429.1	Q5SY80	CA101_HUMAN	chromosome 1 open reading frame 101	570						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	36	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			TCCCTTACATCTGGAAGCACA	0.363000													8	70					0	0	0.038147	0	0
CENPP	401541	broad.mit.edu	37	9	95094556	95094556	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:95094556G>C	ENST00000375587.3	+	2	727	c.212G>C	c.(211-213)aGt>aCt	p.S71T		NM_001012267.1	NP_001012267.1	Q6IPU0	CENPP_HUMAN	centromere protein P	71					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(1)	16						TCATTTCTAAGTACGCTTACT	0.348000													4	31					0	0	0.009096	0	0
CHD2	1106	broad.mit.edu	37	15	93518123	93518123	+	Silent	SNP	C	C	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:93518123C>A	ENST00000394196.4	+	20	3588	c.2520C>A	c.(2518-2520)tcC>tcA	p.S840S	CHD2_ENST00000557381.1_Silent_p.S840S	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	840	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TGGATGGTTCCATCAAGGGAG	0.433000													11	62					0.000308642	0.000324745	0.132662	1	0
GNS	2799	broad.mit.edu	37	12	65130831	65130831	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:65130831G>A	ENST00000258145.3	-	9	1221	c.1051C>T	c.(1051-1053)Cca>Tca	p.P351S	GNS_ENST00000543646.1_Missense_Mutation_p.P383S|GNS_ENST00000418919.2_Missense_Mutation_p.P295S|GNS_ENST00000542058.1_Missense_Mutation_p.P331S	NM_002076.3	NP_002067.1	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase	351						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(4)	15	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		ACCAACAGTGGAACTTTGATA	0.458000													5	73					0	0	0.014758	0	0
DDB1	1642	broad.mit.edu	37	11	61089130	61089130	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:61089130G>A	ENST00000301764.7	-	10	1559	c.1162C>T	c.(1162-1164)Cgg>Tgg	p.R388W	DDB1_ENST00000545930.1_5'UTR|DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	388	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CGGATGATCCGCAAAGAACCT	0.473000								Nucleotide excision repair (NER)					19	235					0	0	0.055883	0	0
ZNF827	152485	broad.mit.edu	37	4	146767142	146767142	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:146767142G>A	ENST00000508784.1	-	7	2472	c.2245C>T	c.(2245-2247)Cat>Tat	p.H749Y	ZNF827_ENST00000379448.4_Missense_Mutation_p.H749Y|ZNF827_ENST00000513320.1_Missense_Mutation_p.H399Y			Q17R98	ZN827_HUMAN	zinc finger protein 827	749					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TCTTTTGTATGATTGTGCTCT	0.463000													4	48					0	0	0.009096	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	38					0	0	0.009096	0	0
ATP11A	23250	broad.mit.edu	37	13	113508638	113508638	+	Silent	SNP	C	C	T	rs144429120		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr13:113508638C>T	ENST00000487903.1	+	19	2125	c.2037C>T	c.(2035-2037)gcC>gcT	p.A679A	ATP11A_ENST00000375645.3_Silent_p.A679A|ATP11A_ENST00000283558.8_Silent_p.A679A|ATP11A_ENST00000375630.2_Silent_p.A679A			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	679					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGCAGAAGGCCGGGATCAAAG	0.592000													5	57					0	0	0.014758	0	0
RYR2	6262	broad.mit.edu	37	1	237961367	237961367	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:237961367C>T	ENST00000366574.2	+	97	14304	c.13987C>T	c.(13987-13989)Cga>Tga	p.R4663*	RYR2_ENST00000542537.1_Nonsense_Mutation_p.R4647*|RYR2_ENST00000360064.6_Nonsense_Mutation_p.R4669*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4663					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTCTACGGCCGAGACAGAAT	0.408000													3	17					0	0	0.115264	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52715983	52715983	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:52715983G>A	ENST00000322088.6	+	5	606	c.548G>A	c.(547-549)cGg>cAg	p.R183Q	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.R128Q|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.R4Q	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	183	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183Q(10)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ATGGTGCGGCGGGCCGCAGCC	0.617000			Mis		clear cell ovarian carcinoma								15	66					0	0	0.119110	0	0
GALNT12	79695	broad.mit.edu	37	9	101585618	101585618	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:101585618C>T	ENST00000375011.3	+	2	452	c.452C>T	c.(451-453)aCt>aTt	p.T151I		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	151	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				GCCTGGTCAACTCTCCTTCGG	0.428000													5	84					0	0	0.014758	0	0
DDB1	1642	broad.mit.edu	37	11	61090509	61090509	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:61090509G>A	ENST00000301764.7	-	8	1376	c.979C>T	c.(979-981)Cgc>Tgc	p.R327C	DDB1_ENST00000545930.1_5'UTR|DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	327	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						TCACCCAGGCGAGACCCGACA	0.438000								Nucleotide excision repair (NER)					3	31					0	0	0.115264	0	0
SMAD4	4089	broad.mit.edu	37	18	48573554	48573554	+	Silent	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:48573554G>A	ENST00000342988.3	+	2	676	c.138G>A	c.(136-138)aaG>aaA	p.K46K	SMAD4_ENST00000588745.1_Silent_p.K46K|SMAD4_ENST00000398417.2_Silent_p.K46K|RP11-729L2.2_ENST00000590722.2_3'UTR|SMAD4_ENST00000452201.2_Silent_p.K46K	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	46	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(5)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TGGTAAAGAAGCTGAAGGAGA	0.368000													7	86					0	0	0.038147	0	0
SEC23B	10483	broad.mit.edu	37	20	18491571	18491571	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr20:18491571C>T	ENST00000336714.3	+	2	524	c.92C>T	c.(91-93)gCt>gTt	p.A31V	SEC23B_ENST00000377465.1_Missense_Mutation_p.A31V|SEC23B_ENST00000262544.2_Missense_Mutation_p.A31V|SEC23B_ENST00000377475.3_Missense_Mutation_p.A31V	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	31					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						CGGCTGGAGGCTACAAGAATG	0.502000													8	103					0	0	0.038147	0	0
ZNF594	84622	broad.mit.edu	37	17	5085805	5085805	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:5085805G>C	ENST00000399604.4	-	1	1887	c.1747C>G	c.(1747-1749)Ctc>Gtc	p.L583V	ZNF594_ENST00000575779.1_Missense_Mutation_p.L583V			Q96JF6	ZN594_HUMAN	zinc finger protein 594	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TGTCTGATGAGGTCTGAGCTG	0.458000													17	198					0	0	0.043863	0	0
OTOP2	92736	broad.mit.edu	37	17	72926892	72926892	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:72926892G>A	ENST00000331427.4	+	6	1254	c.1162G>A	c.(1162-1164)Gtg>Atg	p.V388M	OTOP2_ENST00000580223.1_Missense_Mutation_p.V388M	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	388						integral to membrane		p.V388L(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					CTACTCCATCGTGGCTGTGGT	0.617000													6	63					0	0	0.021553	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624346	33624346	+	Silent	SNP	C	C	T			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:33624346C>T	ENST00000504830.1	-	14	2468	c.2133G>A	c.(2131-2133)aaG>aaA	p.K711K	ADAMTS12_ENST00000352040.3_Intron|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	711	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CAGATCCTTCCTTCTGCTTAA	0.453000										HNSCC(64;0.19)			6	104					0	0	0.029380	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	30					0	0	0.115264	0	0
ZNF302	55900	broad.mit.edu	37	19	35173684	35173684	+	Silent	SNP	G	G	A	rs149807567	by1000genomes	TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:35173684G>A	ENST00000505365.2	+	3	348	c.12G>A	c.(10-12)gtG>gtA	p.V4V	ZNF302_ENST00000505242.1_Silent_p.V4V|ZNF302_ENST00000509528.1_Intron|ZNF302_ENST00000507959.1_Silent_p.V4V|ZNF302_ENST00000457781.2_Silent_p.V4V|ZNF302_ENST00000446502.2_Silent_p.V48V|ZNF302_ENST00000423823.2_Silent_p.V4V			Q9NR11	ZN302_HUMAN	zinc finger protein 302	4	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TATTTCAGGTGACATTTAGTG	0.433000													7	64					0	0	0.029380	0	0
PTPRN2	5799	broad.mit.edu	37	7	158380276	158380277	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:158380276_158380277insG	ENST00000389413.3	-	1	188_189	c.85_86insC	c.(85-87)cggfs	p.R29fs	PTPRN2_ENST00000409483.1_Frame_Shift_Ins_p.R29fs|PTPRN2_ENST00000389416.4_Frame_Shift_Ins_p.R29fs|PTPRN2_ENST00000389418.4_Frame_Shift_Ins_p.R29fs	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	29						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTGCCGGCCGCGGGGGACGGAC	0.757													2	4	---	---	---	---					
SURF2	6835	broad.mit.edu	37	9	136226880	136226882	+	In_Frame_Del	DEL	GGA	GGA	-	rs149969130		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:136226880_136226882delGGA	ENST00000371964.4	+	4	433_435	c.392_394delGGA	c.(391-396)cgg>c	p.RR133del	SURF2_ENST00000495524.1_3'UTR	NM_017503.3	NP_059973.3	Q15527	SURF2_HUMAN	surfeit 2	133							protein binding			breast(1)|large_intestine(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		CTGGTGCACCGGAGGAGGAGGAG	0.635													7	35	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25299375	25299376	+	RNA	INS	-	-	A			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:25299375_25299376insA	ENST00000549804.2	+	0	98				SNHG14_ENST00000547292.1_RNA|SNORD116-2_ENST00000384274.1_RNA																							GATGAGTCCCCAAAAAAAACAT	0.495													9	210	---	---	---	---					
LOC146880	146880	broad.mit.edu	37	17	62750914	62750914	+	RNA	DEL	T	T	-			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:62750914delT	ENST00000400873.3	-	0	1841					NR_026899.1																						CTGATTATGCttttttttttg	0.433													3	4	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47030561	47030563	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chrX:47030561_47030563delGGA	ENST00000377604.3	+	4	1078_1080	c.336_338delGGA	c.(334-339)ggg>gg	p.GE112del	RBM10_ENST00000468791.1_3'UTR|RBM10_ENST00000345781.6_Intron|RBM10_ENST00000329236.7_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	112					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						CCGAGCAAGGggaggaggaggag	0.660													4	9	---	---	---	---