Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF345	25850	broad.mit.edu	37	19	37367985	37367985	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:37367985A>G	ENST00000529555.1	+	2	1041	c.253A>G	c.(253-255)Act>Gct	p.T85A	ZNF345_ENST00000420450.1_Missense_Mutation_p.T85A|ZNF345_ENST00000589046.1_Missense_Mutation_p.T85A|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000432005.2_Intron			Q14585	ZN345_HUMAN	zinc finger protein 345	85					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCGAATTCATACTGGTGAGAA	0.403000													6	38					0	0	0.001168	0	0
F5	2153	broad.mit.edu	37	1	169511663	169511663	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:169511663T>A	ENST00000367796.3	-	13	2881	c.2680A>T	c.(2680-2682)Aaa>Taa	p.K894*	F5_ENST00000367797.3_Nonsense_Mutation_p.K889*			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	889	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTCCCAACTTTATGTGCTAGT	0.473000													32	133					0	0	0.001786	0	0
DMD	1756	broad.mit.edu	37	X	31496480	31496480	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:31496480C>G	ENST00000357033.4	-	59	8886	c.8680G>C	c.(8680-8682)Gag>Cag	p.E2894Q	DMD_ENST00000378707.3_Missense_Mutation_p.E434Q|DMD_ENST00000445312.1_5'UTR|DMD_ENST00000343523.2_Missense_Mutation_p.E434Q|DMD_ENST00000378677.2_Missense_Mutation_p.E2890Q|DMD_ENST00000359836.1_Missense_Mutation_p.E434Q|DMD_ENST00000541735.1_Missense_Mutation_p.E434Q|DMD_ENST00000474231.1_Missense_Mutation_p.E434Q	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2894					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCTCTCTCCTCAGGAGGCAGC	0.443000													17	83					0	0	0.000958	0	0
SRFBP1	153443	broad.mit.edu	37	5	121355833	121355833	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:121355833T>A	ENST00000339397.4	+	6	475	c.403T>A	c.(403-405)Tca>Aca	p.S135T		NM_152546.2	NP_689759.2	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|skin(1)	15		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TGAAGTTGAGTCATCAAAGAA	0.368000													12	31					0	0	0.001855	0	0
LHFP	10186	broad.mit.edu	37	13	39952599	39952599	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:39952599C>G	ENST00000379589.3	-	3	912	c.450G>C	c.(448-450)caG>caC	p.Q150H		NM_005780.2	NP_005771.1	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner	150						integral to membrane	DNA binding		HMGA2/LHFP(2)	breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(6)|prostate(2)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		AGCCACAAGTCTGCCGGACTT	0.493000			T	HMGA2	lipoma								16	51					0	0	0.003163	0	0
SYPL2	284612	broad.mit.edu	37	1	110020605	110020605	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:110020605T>A	ENST00000369872.3	+	5	838	c.622T>A	c.(622-624)Tct>Act	p.S208T	SYPL2_ENST00000401021.3_Intron	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	208	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCCACGCCCTCTATGGGCCT	0.637000													9	29					0	0	0.000443	0	0
PRRC2B	84726	broad.mit.edu	37	9	134308156	134308156	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:134308156A>T	ENST00000357304.4	+	2	323	c.268A>T	c.(268-270)Aag>Tag	p.K90*	PRRC2B_ENST00000458550.1_Nonsense_Mutation_p.K90*|PRRC2B_ENST00000405995.1_Nonsense_Mutation_p.K90*	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	90							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						ATGGGCAAACAAGCAGGATCA	0.577000													7	50					0	0	0.001984	0	0
TLL1	7092	broad.mit.edu	37	4	166795090	166795090	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:166795090G>A	ENST00000061240.2	+	1	681	c.34G>A	c.(34-36)Gtg>Atg	p.V12M	TLL1_ENST00000507499.1_Missense_Mutation_p.V12M|TLL1_ENST00000513213.1_Missense_Mutation_p.V12M	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	12					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GAGGATGCTCGTGTGGCTGGT	0.592000													8	120					0	0	0.004482	0	0
OR8B2	26595	broad.mit.edu	37	11	124252330	124252330	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:124252330G>A	ENST00000375013.2	-	1	928	c.910C>T	c.(910-912)Ctg>Ttg	p.L304L		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ATTTTAATCAGAGCTTTCCTC	0.338000													16	37					0	0	0.004007	0	0
ACOT11	26027	broad.mit.edu	37	1	55059688	55059688	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:55059688C>T	ENST00000371316.3	+	5	529	c.447C>T	c.(445-447)ttC>ttT	p.F149F	ACOT11_ENST00000343744.2_Silent_p.F149F|ACOT11_ENST00000481208.1_3'UTR	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	149	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						TGGCCACCTTCGTGGCCCGCC	0.632000													8	49					0	0	0.004482	0	0
SPTA1	6708	broad.mit.edu	37	1	158595971	158595971	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:158595971C>A	ENST00000368148.3	-	42	6055	c.5875G>T	c.(5875-5877)Gac>Tac	p.D1959Y	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.D1956Y	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1959					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.D1959H(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCACCAAGGTCTGCACCATTG	0.423000													8	34					1.12685e-05	2.36484e-05	0.004482	1	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	56					0	0	0.000673	0	0
TAF1L	138474	broad.mit.edu	37	9	32631662	32631662	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:32631662C>T	ENST00000242310.4	-	1	4005	c.3916G>A	c.(3916-3918)Gtg>Atg	p.V1306M		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1306					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAAGGTGGCACATTTGTTTGA	0.428000													91	134					0	0	0.003610	0	0
DOCK2	1794	broad.mit.edu	37	5	169484632	169484632	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:169484632G>C	ENST00000256935.8	+	44	4509	c.4429G>C	c.(4429-4431)Ggg>Cgg	p.G1477R	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.G969R|DOCK2_ENST00000540750.1_Missense_Mutation_p.G538R	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1477	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAAGCTGCCGGGGATCCTGCG	0.582000													12	43					0	0	0.001368	0	0
ZNF98	148198	broad.mit.edu	37	19	22575547	22575547	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:22575547G>A	ENST00000357774.5	-	4	611	c.490C>T	c.(490-492)Cat>Tat	p.H164Y		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GAAAATTTATGAAAGACTTTC	0.313000													3	7					0	0	0.004672	0	0
FLG	2312	broad.mit.edu	37	1	152283044	152283044	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:152283044A>G	ENST00000368799.1	-	3	4353	c.4318T>C	c.(4318-4320)Tct>Cct	p.S1440P	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1440	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGAGGAAAGACCTTGAACGT	0.587000									Ichthyosis				15	273					0	0	0.002450	0	0
ZNF521	25925	broad.mit.edu	37	18	22806305	22806305	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:22806305G>C	ENST00000361524.3	-	4	1725	c.1577C>G	c.(1576-1578)tCt>tGt	p.S526C	ZNF521_ENST00000584787.1_Missense_Mutation_p.S306C|ZNF521_ENST00000538137.2_Missense_Mutation_p.S526C	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	526					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTCCAGGGAAGAGTCAGTGAG	0.468000			T	PAX5	ALL								7	70					0	0	0.001984	0	0
CLEC16A	23274	broad.mit.edu	37	16	11071128	11071128	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:11071128G>C	ENST00000409790.1	+	8	1005	c.775G>C	c.(775-777)Gac>Cac	p.D259H	CLEC16A_ENST00000409552.3_Missense_Mutation_p.D257H	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	259										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AGAGCACCTAGACCACCTGCA	0.537000													11	69					0	0	0.000978	0	0
GUCA1A	2978	broad.mit.edu	37	6	42146620	42146620	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:42146620C>T	ENST00000394237.1	+	5	1408	c.432C>T	c.(430-432)gaC>gaT	p.D144D	GUCA1A_ENST00000053469.4_Silent_p.D144D|GUCA1A_ENST00000372958.1_Silent_p.D144D|GUCA1A_ENST00000541991.1_Silent_p.D144D			P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	144	EF-hand 4.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	7	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCAAGATTGACGTCAACGGGG	0.607000													28	70					0	0	0.001061	0	0
CNTN3	5067	broad.mit.edu	37	3	74411068	74411068	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:74411068C>T	ENST00000263665.6	-	10	1364	c.1337G>A	c.(1336-1338)gGg>gAg	p.G446E		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	446	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GCTCACATCCCCCTTCTTCCA	0.473000													12	35					0	0	0.000978	0	0
DCAF8	50717	broad.mit.edu	37	1	160209906	160209906	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:160209906C>G	ENST00000368073.3	-	4	738	c.304G>C	c.(304-306)Gag>Cag	p.E102Q	DCAF8_ENST00000461888.1_5'UTR|DCAF8_ENST00000368074.1_Missense_Mutation_p.E102Q|DCAF8_ENST00000556710.1_Missense_Mutation_p.E256Q|DCAF8_ENST00000326837.2_Missense_Mutation_p.E102Q			Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	102						CUL4 RING ubiquitin ligase complex	protein binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(16)|skin(3)|upper_aerodigestive_tract(1)	33						tcctcttcctcttcctctGAG	0.537000													3	28					0	0	0.004672	0	0
CPB1	1360	broad.mit.edu	37	3	148562481	148562481	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:148562481G>T	ENST00000491148.1	+	9	1039	c.705G>T	c.(703-705)aaG>aaT	p.K235N	CPB1_ENST00000282957.4_Missense_Mutation_p.K235N			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	235					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGGAGAAAGACTCGCTCCA	0.438000													14	101					9.05144e-12	2.11384e-11	0.001855	1	0
ABLIM1	3983	broad.mit.edu	37	10	116444079	116444079	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:116444079C>A	ENST00000369252.4	-	1	335	c.34G>T	c.(34-36)Gac>Tac	p.D12Y	ABLIM1_ENST00000533213.2_Missense_Mutation_p.D12Y	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	0					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TGATGAGGGTCCGTGAGCTCA	0.468000													12	62					3.27435e-08	7.16615e-08	0.002450	1	0
ADAM33	80332	broad.mit.edu	37	20	3655732	3655732	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:3655732T>A	ENST00000356518.2	-	4	516	c.275A>T	c.(274-276)tAc>tTc	p.Y92F	ADAM33_ENST00000350009.2_Missense_Mutation_p.Y92F|ADAM33_ENST00000379861.4_Missense_Mutation_p.Y92F	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	92					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						GGTTTCTATGTATCCTGGGGC	0.602000													21	52					0	0	0.002299	0	0
OR2A14	135941	broad.mit.edu	37	7	143826781	143826781	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:143826781G>C	ENST00000408899.2	+	1	631	c.576G>C	c.(574-576)tgG>tgC	p.W192C		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					CTGACACCTGGCTCAACCAGG	0.562000													48	240					0	0	0.003610	0	0
ZNF841	284371	broad.mit.edu	37	19	52570837	52570837	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:52570837C>T	ENST00000389534.4	-	7	757	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	ZNF841_ENST00000594295.1_Missense_Mutation_p.E100K|ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000426391.2_5'UTR	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						GGTGGTAATTCCTTGATCACA	0.323000													4	28					0	0	0.000602	0	0
TTC13	79573	broad.mit.edu	37	1	231076226	231076226	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:231076226C>A	ENST00000366661.4	-	7	756	c.749G>T	c.(748-750)cGg>cTg	p.R250L	TTC13_ENST00000414259.1_Missense_Mutation_p.R197L|TTC13_ENST00000366662.4_Missense_Mutation_p.R197L	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	250							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TCTGTACAGCCGTGCTGAGGG	0.423000													7	35					0.00198382	0.00390644	0.001984	1	0
PLCZ1	89869	broad.mit.edu	37	12	18854534	18854534	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:18854534G>C	ENST00000538330.1	-	5	645	c.264C>G	c.(262-264)ttC>ttG	p.F88L	PLCZ1_ENST00000541695.1_Intron|PLCZ1_ENST00000542762.1_Intron|PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000447925.2_Intron|PLCZ1_ENST00000435379.1_Intron|PLCZ1_ENST00000266505.7_Intron			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	317					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CTGATTCTTTGAATTTAtcct	0.448000													6	30					0	0	0.001168	0	0
FREM2	341640	broad.mit.edu	37	13	39425083	39425083	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:39425083G>C	ENST00000280481.7	+	10	6796	c.6580G>C	c.(6580-6582)Gag>Cag	p.E2194Q		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2194	Calx-beta 4.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTTCCAGGTGAGACAGAAAA	0.478000													11	49					0	0	0.001855	0	0
ABCA1	19	broad.mit.edu	37	9	107618116	107618116	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:107618116C>G	ENST00000423487.2	-	8	1270	c.974G>C	c.(973-975)tGg>tCg	p.W325S	ABCA1_ENST00000374736.3_Intron			O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	0					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCAGAGCACCCAGATTCTGAA	0.458000													6	20					0	0	0.001168	0	0
COL5A1	1289	broad.mit.edu	37	9	137716625	137716625	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:137716625A>T	ENST00000371817.3	+	62	5292	c.4878A>T	c.(4876-4878)aaA>aaT	p.K1626N		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1626	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCAGATGAAACGGCCCCTGG	0.632000													10	31					0	0	0.000673	0	0
FEM1A	55527	broad.mit.edu	37	19	4792971	4792971	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:4792971G>A	ENST00000269856.3	+	1	1244	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	369					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CGACCCGGATGAGATGCGCAT	0.632000													16	61					0	0	0.003163	0	0
ARX	170302	broad.mit.edu	37	X	25033720	25033720	+	Silent	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:25033720T>A	ENST00000379044.4	-	1	345	c.135A>T	c.(133-135)ggA>ggT	p.G45G		NM_139058.2	NP_620689.1	Q96QS3	ARX_HUMAN	aristaless related homeobox	45						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(1)	4						TCTGCGCGGCTCCCAGCAACC	0.607000													5	24					0	0	0.001168	0	0
MYADM	91663	broad.mit.edu	37	19	54377171	54377171	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:54377171C>A	ENST00000391769.2	+	3	668	c.388C>A	c.(388-390)Cac>Aac	p.H130N	MYADM_ENST00000391768.2_Missense_Mutation_p.H130N|MYADM_ENST00000391770.4_Missense_Mutation_p.H130N|MYADM_ENST00000391771.1_Missense_Mutation_p.H130N|MYADM_ENST00000336967.3_Missense_Mutation_p.H130N	NM_001020821.1	NP_001018657.1	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	130	MARVEL 1.					integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		GTTCCTGTCCCACGGCCGTTC	0.662000													20	98					7.45023e-12	1.74522e-11	0.001523	1	0
ADARB1	104	broad.mit.edu	37	21	46596174	46596174	+	Silent	SNP	G	G	A	rs146135960	byFrequency	TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr21:46596174G>A	ENST00000539173.1	+	4	993	c.558G>A	c.(556-558)gcG>gcA	p.A186A	ADARB1_ENST00000360697.3_Silent_p.A186A|ADARB1_ENST00000437626.1_Intron|ADARB1_ENST00000389863.4_Silent_p.A186A|ADARB1_ENST00000348831.4_Silent_p.A186A	NM_015833.3	NP_056648.1	P78563	RED1_HUMAN	adenosine deaminase, RNA-specific, B1	186					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(1)	17				Colorectal(79;0.115)		CTGACAAGGCGGAGCCTCCCT	0.592000													6	26					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9068476	9068476	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:9068476C>T	ENST00000397910.4	-	3	19173	c.18970G>A	c.(18970-18972)Gac>Aac	p.D6324N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6326	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTATATGGGTCTGAGTCAGGT	0.443000													9	79					0	0	0.000443	0	0
P2RX3	5024	broad.mit.edu	37	11	57118259	57118259	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:57118259C>T	ENST00000263314.2	+	8	763	c.729C>T	c.(727-729)atC>atT	p.I243I		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	243					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity	p.I243I(1)		endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						GCATTAAGATCGGCTGGGTGT	0.622000													4	26					0	0	0.000248	0	0
GRID2	2895	broad.mit.edu	37	4	94693335	94693335	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:94693335C>G	ENST00000282020.4	+	16	2968	c.2710C>G	c.(2710-2712)Cct>Gct	p.P904A	GRID2_ENST00000510992.1_Missense_Mutation_p.P809A	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	904					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGATTTGACCCCTCTGGACAT	0.458000													5	80					0	0	0.001168	0	0
LINGO2	158038	broad.mit.edu	37	9	27950478	27950478	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:27950478G>A	ENST00000379992.2	-	6	641	c.192C>T	c.(190-192)ctC>ctT	p.L64L	LINGO2_ENST00000308675.3_Silent_p.L64L	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	64						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TGTTTTTACTGAGGTCCAAGA	0.458000													72	94					0	0	0.003610	0	0
UGCG	7357	broad.mit.edu	37	9	114676936	114676936	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:114676936C>T	ENST00000374279.3	+	2	600	c.150C>T	c.(148-150)ctC>ctT	p.L50L	UGCG_ENST00000495085.1_3'UTR	NM_003358.1	NP_003349.1	Q16739	CEGT_HUMAN	UDP-glucose ceramide glucosyltransferase	50					epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	12				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	ATAGCAAGCTCCCAGGTGTCT	0.368000													13	52					0	0	0.003163	0	0
KAT6A	7994	broad.mit.edu	37	8	41791507	41791507	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:41791507C>G	ENST00000396930.3	-	18	4774	c.4231G>C	c.(4231-4233)Gag>Cag	p.E1411Q	KAT6A_ENST00000265713.2_Missense_Mutation_p.E1411Q|KAT6A_ENST00000406337.1_Missense_Mutation_p.E1411Q	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1411	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCTTCCTCCTCTTTTAATTCG	0.507000													20	72					0	0	0.000958	0	0
COL28A1	340267	broad.mit.edu	37	7	7412695	7412695	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:7412695C>G	ENST00000399429.3	-	32	2982	c.2842G>C	c.(2842-2844)Gaa>Caa	p.E948Q		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	948	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		AGATTCATTTCTTTGTGGAAT	0.428000													8	39					0	0	0.004482	0	0
RILPL1	353116	broad.mit.edu	37	12	124008157	124008157	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:124008157C>T	ENST00000376874.4	-	2	580	c.345G>A	c.(343-345)gaG>gaA	p.E115E		NM_178314.3	NP_847884.2	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	115					neuroprotection	cytosol				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGTCCTGCGCCTCCCCTCGCC	0.627000													10	31					0	0	0.000443	0	0
TAF1L	138474	broad.mit.edu	37	9	32633519	32633519	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:32633519G>A	ENST00000242310.4	-	1	2148	c.2059C>T	c.(2059-2061)Cct>Tct	p.P687S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	687					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGATCCTGAGGTGTGCGCATA	0.433000													6	117					0	0	0.001168	0	0
USP8	9101	broad.mit.edu	37	15	50786338	50786338	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:50786338G>A	ENST00000433963.1	+	17	3019	c.2519G>A	c.(2518-2520)gGa>gAa	p.G840E	USP8_ENST00000307179.4_Missense_Mutation_p.G840E|USP8_ENST00000425032.3_Missense_Mutation_p.G734E|USP8_ENST00000396444.3_Missense_Mutation_p.G840E|RP11-562A8.5_ENST00000560159.1_lincRNA	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	840					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTGTGGACAGGACAGTATAGA	0.383000													19	87					0	0	0.006122	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:7578406C>T	ENST00000420246.2	-	5	656	c.524G>A	c.(523-525)cGc>cAc	p.R175H	TP53_ENST00000455263.2_Missense_Mutation_p.R175H|TP53_ENST00000269305.4_Missense_Mutation_p.R175H|TP53_ENST00000445888.2_Missense_Mutation_p.R175H|TP53_ENST00000359597.4_Missense_Mutation_p.R175H|TP53_ENST00000413465.2_Missense_Mutation_p.R175H|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	175	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(847)|p.R43H(36)|p.R82H(36)|p.R175L(19)|p.0?(8)|p.R175P(6)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*5(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(AU565_BREAST)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(HCC1395_BREAST)|R175H(HUCCT1_BILIARY_TRACT)|R175H(KLE_ENDOMETRIUM)|R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(LS123_LARGE_INTESTINE)|R175H(NCIH196_LUNG)|R175H(RKN_OVARY)|R175H(SKBR3_BREAST)|R175H(SKUT1_SOFT_TISSUE)|R175H(TYKNU_OVARY)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	36					0	0	0.001855	0	0
RPL3L	6123	broad.mit.edu	37	16	1996719	1996719	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:1996719G>C	ENST00000268661.7	-	7	952	c.858C>G	c.(856-858)cgC>cgG	p.R286R		NM_005061.2	NP_005052.1	Q92901	RL3L_HUMAN	ribosomal protein L3-like	286					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						CCCTGCCGATGCGGAAGATCT	0.632000													8	28					0	0	0.004482	0	0
ADCY5	111	broad.mit.edu	37	3	123019032	123019032	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:123019032G>A	ENST00000462833.1	-	15	4047	c.2835C>T	c.(2833-2835)ctC>ctT	p.L945L	ADCY5_ENST00000309879.5_Silent_p.L595L|ADCY5_ENST00000491190.1_Silent_p.L578L	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	945					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CCTCCACGATGAGCACGTAGA	0.632000													5	58					0	0	0.000602	0	0
GPAT2	150763	broad.mit.edu	37	2	96689186	96689186	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:96689186G>A	ENST00000434632.1	-	19	2358	c.1899C>T	c.(1897-1899)acC>acT	p.T633T	GPAT2_ENST00000377137.3_Intron|GPAT2_ENST00000359548.4_Silent_p.T633T|GPAT2_ENST00000453542.1_Silent_p.T562T			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	633					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						GGGAGCCTGGGGTCTAGGGGC	0.567000													10	41					0	0	0.000978	0	0
DPYD	1806	broad.mit.edu	37	1	98015229	98015229	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:98015229T>A	ENST00000370192.3	-	12	1511	c.1411A>T	c.(1411-1413)Act>Tct	p.T471S		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	471					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GCTTCACTAGTTTGCATAGTT	0.403000													10	21					0	0	0.000673	0	0
CENPE	1062	broad.mit.edu	37	4	104035710	104035710	+	Splice_Site	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:104035710C>T	ENST00000265148.3	-	46	7532		c.e46-1		CENPE_ENST00000380026.3_Splice_Site	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AGCACTGATTCTAACAAAAAC	0.348000													5	25					0	0	0.000602	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511596	130511596	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:130511596C>A	ENST00000314830.8	-	5	1146	c.1033G>T	c.(1033-1035)Gtc>Ttc	p.V345F	SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Missense_Mutation_p.V188F|SH2D3C_ENST00000373276.3_Missense_Mutation_p.V277F|SH2D3C_ENST00000429553.1_5'UTR|SH2D3C_ENST00000373274.3_Missense_Mutation_p.V185F|SH2D3C_ENST00000420366.1_Missense_Mutation_p.V187F	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	345					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GAGGGGCTGACGGGGCTAGCA	0.657000													12	51					0.000978159	0.00196659	0.000978	1	0
IFI16	3428	broad.mit.edu	37	1	159021690	159021690	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:159021690C>G	ENST00000295809.7	+	10	2142	c.1887C>G	c.(1885-1887)atC>atG	p.I629M	IFI16_ENST00000448393.2_Missense_Mutation_p.I517M|IFI16_ENST00000368131.4_Missense_Mutation_p.I573M|IFI16_ENST00000368132.3_Missense_Mutation_p.I573M|IFI16_ENST00000340979.6_Missense_Mutation_p.I517M|IFI16_ENST00000430894.2_Missense_Mutation_p.I577M|IFI16_ENST00000359709.3_Missense_Mutation_p.I573M			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	629	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					CAAAGAAGATCATTGCCATAG	0.423000													13	59					0	0	0.001368	0	0
KBTBD3	143879	broad.mit.edu	37	11	105924580	105924580	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:105924580T>G	ENST00000526793.1	-	3	995	c.836A>C	c.(835-837)cAa>cCa	p.Q279P	KBTBD3_ENST00000534815.1_Missense_Mutation_p.Q200P|KBTBD3_ENST00000531837.1_Missense_Mutation_p.Q279P	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	275										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		ACCAGAACCTTGCACACACTT	0.378000													4	54					0	0	0.000248	0	0
PGM5	5239	broad.mit.edu	37	9	71002492	71002492	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:71002492G>C	ENST00000396396.1	+	4	914	c.685G>C	c.(685-687)Gca>Cca	p.A229P	PGM5_ENST00000604870.2_3'UTR|PGM5_ENST00000396392.1_Missense_Mutation_p.A229P	NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	229					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						TCGCATTGACGCAATGCACGG	0.468000													7	55					0	0	0.001984	0	0
PXDN	7837	broad.mit.edu	37	2	1664703	1664703	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:1664703G>C	ENST00000252804.4	-	14	1837	c.1787C>G	c.(1786-1788)gCc>gGc	p.A596G		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	596	Ig-like C2-type 4.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTGTTCCGGGCCACACACTC	0.522000													5	57					0	0	0.001984	0	0
HTR1A	3350	broad.mit.edu	37	5	63256923	63256923	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:63256923C>A	ENST00000323865.3	-	1	857	c.624G>T	c.(622-624)ctG>ctT	p.L208L	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	208					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCATGAGCAGCAGCGGGATGT	0.592000													37	122					2.66277e-13	6.31479e-13	0.001485	1	0
MYH13	8735	broad.mit.edu	37	17	10213055	10213055	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:10213055C>A	ENST00000418404.3	-	33	4912	c.4749G>T	c.(4747-4749)aaG>aaT	p.K1583N	MYH13_ENST00000252172.4_Missense_Mutation_p.K1583N|MYH13_ENST00000570743.1_Missense_Mutation_p.K1583N			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1583					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TTTCTTCATCCTTCTCAATGA	0.562000													3	7					6.4e-05	0.000131785	0.004672	1	0
HIC2	23119	broad.mit.edu	37	22	21799710	21799710	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:21799710C>T	ENST00000443632.2	+	2	898	c.526C>T	c.(526-528)Cag>Tag	p.Q176*	HIC2_ENST00000407598.2_Nonsense_Mutation_p.Q176*|HIC2_ENST00000407464.2_Nonsense_Mutation_p.Q176*			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	176				Q -> R (in Ref. 3; BAA82972).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				AGCTCGGTATCAGGGGCTCGT	0.677000													14	12					0	0	0.003163	0	0
ING5	84289	broad.mit.edu	37	2	242662623	242662623	+	Splice_Site	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:242662623A>T	ENST00000313552.6	+	7	644		c.e7-1		ING5_ENST00000406941.1_Splice_Site	NM_032329.4	NP_115705.2	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5						DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			large_intestine(1)|lung(1)|skin(1)	3		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TTTACTTTGCAGTGTCCAATT	0.522000													57	191					0	0	0.003610	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964112	73964112	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:73964112C>T	ENST00000373468.1	-	3	931	c.280G>A	c.(280-282)Gct>Act	p.A94T	KIAA2022_ENST00000055682.5_Missense_Mutation_p.A94T			Q5QGS0	K2022_HUMAN	KIAA2022	94					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTCACAGAAGCACTATTAGCA	0.512000													21	101					0	0	0.001523	0	0
FAM214B	80256	broad.mit.edu	37	9	35107755	35107755	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:35107755C>T	ENST00000378561.1	-	2	3572	c.517G>A	c.(517-519)Gag>Aag	p.E173K	FAM214B_ENST00000603301.1_Missense_Mutation_p.E173K|FAM214B_ENST00000322813.5_Missense_Mutation_p.E173K|FAM214B_ENST00000378557.1_Missense_Mutation_p.E173K|FAM214B_ENST00000378566.1_Intron|FAM214B_ENST00000488109.2_Missense_Mutation_p.E173K|FAM214B_ENST00000378554.2_Missense_Mutation_p.E173K|FAM214B_ENST00000605244.1_Missense_Mutation_p.E173K			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	173						nucleus											CCTGGGGACTCCCCCAGGGAC	0.632000													15	109					0	0	0.003163	0	0
KCNK10	54207	broad.mit.edu	37	14	88707107	88707107	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:88707107T>A	ENST00000340700.5	-	3	896	c.445A>T	c.(445-447)Agc>Tgc	p.S149C	KCNK10_ENST00000312350.5_Missense_Mutation_p.S154C|KCNK10_ENST00000319231.5_Missense_Mutation_p.S154C	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	149					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						CAGTGGCTGCTGTTGTTGGAA	0.458000													27	105					0	0	0.003954	0	0
ZNF136	7695	broad.mit.edu	37	19	12297490	12297490	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:12297490G>A	ENST00000343979.4	+	4	437	c.297G>A	c.(295-297)gtG>gtA	p.V99V	ZNF136_ENST00000398616.2_Silent_p.V33V	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	99					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						TCCCTGGAGTGAAACTCTGTG	0.398000													5	33					0	0	0.001168	0	0
MUC17	140453	broad.mit.edu	37	7	100679091	100679091	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:100679091C>A	ENST00000306151.4	+	3	4458	c.4394C>A	c.(4393-4395)aCg>aAg	p.T1465K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1465	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCAACACGCCGGTGGCC	0.473000													80	288					5.41795e-27	1.35184e-26	0.003610	1	0
ZNRF3	84133	broad.mit.edu	37	22	29442723	29442723	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:29442723C>A	ENST00000544604.2	+	6	939	c.764C>A	c.(763-765)gCt>gAt	p.A255D	ZNRF3_ENST00000406323.3_Missense_Mutation_p.A155D|ZNRF3_ENST00000402174.1_Missense_Mutation_p.A155D|ZNRF3_ENST00000332811.4_Missense_Mutation_p.A155D	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	255						integral to membrane	zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						AACAGGCTGGCTGTGCAGGCT	0.562000													50	131					4.86159e-25	1.20908e-24	0.003610	1	0
LOC645752	645752	broad.mit.edu	37	15	78212618	78212618	+	RNA	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:78212618A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TGTAACCGCCACTGGAGGACC	0.562000													3	50					0	0	0.004672	0	0
ATP1B3	483	broad.mit.edu	37	3	141622516	141622516	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:141622516C>G	ENST00000539728.1	+	3	415	c.122C>G	c.(121-123)tCa>tGa	p.S41*	ATP1B3_ENST00000462082.1_Missense_Mutation_p.H9D|ATP1B3_ENST00000286371.3_Nonsense_Mutation_p.S55*			P54709	AT1B3_HUMAN	ATPase, Na+/K+ transporting, beta 3 polypeptide	55					ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			cervix(1)|endometrium(1)|lung(2)	4						GCACTCTTCTCATTCACGATG	0.413000													16	81					0	0	0.006122	0	0
CNTN3	5067	broad.mit.edu	37	3	74350693	74350693	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:74350693C>A	ENST00000263665.6	-	15	1978	c.1951G>T	c.(1951-1953)Gag>Tag	p.E651*		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	651	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TCGATGACCTCAGGCACTACA	0.448000													25	48					1.66031e-10	3.7187e-10	0.003954	1	0
TAAR1	134864	broad.mit.edu	37	6	132966284	132966284	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:132966284C>G	ENST00000275216.1	-	1	858	c.859G>C	c.(859-861)Gat>Cat	p.D287H		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	287						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	ATCAATACATCATTCAAAGTA	0.373000													10	45					0	0	0.000443	0	0
UVRAG	7405	broad.mit.edu	37	11	75851885	75851885	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:75851885G>A	ENST00000356136.3	+	15	1769	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	UVRAG_ENST00000538870.1_Missense_Mutation_p.E66K|UVRAG_ENST00000531818.1_Missense_Mutation_p.E138K|UVRAG_ENST00000539288.1_Missense_Mutation_p.E138K|UVRAG_ENST00000532130.1_Missense_Mutation_p.E138K|UVRAG_ENST00000533454.1_Missense_Mutation_p.E138K|UVRAG_ENST00000528420.1_Missense_Mutation_p.E409K	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	510					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						GGCCAGCTCTGAGAATGAGAG	0.527000													7	104					0	0	0.001984	0	0
PES1	23481	broad.mit.edu	37	22	30977575	30977575	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:30977575C>T	ENST00000402281.1	-	9	1261	c.270G>A	c.(268-270)acG>acA	p.T90T	PES1_ENST00000405677.1_Silent_p.T90T|PES1_ENST00000354694.6_Silent_p.T229T|PES1_ENST00000335214.6_Silent_p.T229T|PES1_ENST00000402284.3_Silent_p.T212T			O00541	PESC_HUMAN	pescadillo ribosomal biogenesis factor 1	229	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	29						AGCCCAGCAGCGTGGTGTAGA	0.597000													5	34					0	0	0.000602	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1876769	1876769	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:1876769G>C	ENST00000518288.1	+	25	3109	c.2946G>C	c.(2944-2946)gtG>gtC	p.V982V	ARHGEF10_ENST00000520359.1_Silent_p.V920V|ARHGEF10_ENST00000262112.6_Silent_p.V954V|ARHGEF10_ENST00000349830.3_Silent_p.V958V|ARHGEF10_ENST00000398564.1_Silent_p.V983V			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	983					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CCCCGGCCGTGAGAGCTTCTG	0.612000													6	60					0	0	0.001984	0	0
OR52E6	390078	broad.mit.edu	37	11	5862952	5862952	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:5862952T>A	ENST00000329322.5	-	1	175	c.176A>T	c.(175-177)gAg>gTg	p.E59V	OR52E6_ENST00000379946.2_Missense_Mutation_p.E63V|TRIM5_ENST00000380027.1_Intron	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTACATGGGCTCATGGAGACT	0.463000													17	98					0	0	0.004990	0	0
COX10-AS1	100874058	broad.mit.edu	37	17	13928281	13928281	+	RNA	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:13928281G>A	ENST00000602743.1	-	0	224																											ACCAGCGGCGGAGCCAGAGCC	0.577000													5	8					0	0	0.000602	0	0
SOX13	9580	broad.mit.edu	37	1	204093816	204093816	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:204093816G>A	ENST00000367204.1	+	13	1532	c.1423G>A	c.(1423-1425)Gag>Aag	p.E475K		NM_005686.2	NP_005677.2	Q9UN79	SOX13_HUMAN	SRY (sex determining region Y)-box 13	475					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	13	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCCTACTATGAGGAACAGGC	0.632000													6	18					0	0	0.001984	0	0
OSBPL6	114880	broad.mit.edu	37	2	179259094	179259094	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:179259094G>A	ENST00000190611.4	+	24	3004	c.2628G>A	c.(2626-2628)gaG>gaA	p.E876E	OSBPL6_ENST00000315022.2_Silent_p.E880E|OSBPL6_ENST00000409631.1_Silent_p.E840E|OSBPL6_ENST00000409045.3_Silent_p.E845E|OSBPL6_ENST00000359685.3_Silent_p.E840E|OSBPL6_ENST00000392505.2_Silent_p.E901E	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	876					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			AAAGAGTAGAGGAACTCCAGA	0.348000													22	66					0	0	0.003330	0	0
DLG2	1740	broad.mit.edu	37	11	83673932	83673932	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:83673932T>G	ENST00000398309.2	-	9	1491	c.1021A>C	c.(1021-1023)Acc>Ccc	p.T341P	DLG2_ENST00000418306.2_Missense_Mutation_p.T290P|DLG2_ENST00000543673.1_Missense_Mutation_p.T446P|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000537455.1_Missense_Mutation_p.T95P|DLG2_ENST00000330014.6_Missense_Mutation_p.T280P|DLG2_ENST00000376104.2_Missense_Mutation_p.T446P|DLG2_ENST00000532653.1_Missense_Mutation_p.T341P|DLG2_ENST00000524982.1_Missense_Mutation_p.T341P|DLG2_ENST00000280241.8_Missense_Mutation_p.T380P|DLG2_ENST00000531015.1_Missense_Mutation_p.T308P|DLG2_ENST00000398301.2_Missense_Mutation_p.T380P	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	341						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCTGACCTGGTGTAGTCGTCG	0.418000													4	218					0	0	0.000248	0	0
CELF2	10659	broad.mit.edu	37	10	11047378	11047378	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:11047378A>G	ENST00000379261.4	+	1	120	c.28A>G	c.(28-30)Atg>Gtg	p.M10V	CELF2_ENST00000416382.2_Missense_Mutation_p.M10V	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	10	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						CGCTGTTACTATGAGAAATGA	0.413000													6	182					0	0	0.001984	0	0
GRAMD4	23151	broad.mit.edu	37	22	47033858	47033858	+	Splice_Site	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:47033858G>T	ENST00000406902.1	+	3	496		c.e3+1		GRAMD4_ENST00000361034.3_Splice_Site			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4						apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CATTTCTTACGTGAGTACCAG	0.522000													31	94					9.04072e-19	2.20547e-18	0.003271	1	0
PRSS58	136541	broad.mit.edu	37	7	141952173	141952173	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:141952173C>T	ENST00000552471.1	-	5	913	c.594G>A	c.(592-594)ccG>ccA	p.P198P	PRSS58_ENST00000547058.2_Silent_p.P198P			Q8IYP2	PRS58_HUMAN	protease, serine, 58	198	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						TGCAGATTGCCGGGGCAGCAG	0.393000													7	31					0	0	0.003080	0	0
LMBR1L	55716	broad.mit.edu	37	12	49495950	49495950	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:49495950G>A	ENST00000267102.8	-	11	1225	c.883C>T	c.(883-885)Cgg>Tgg	p.R295W	LMBR1L_ENST00000547382.1_Missense_Mutation_p.R295W|LMBR1L_ENST00000395141.4_Missense_Mutation_p.R290W	NM_018113.2	NP_060583.2	Q6UX01	LMBRL_HUMAN	limb development membrane protein 1-like	295					endocytosis	integral to membrane|plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CCCAGGTTCCGTTGCCAGGCT	0.597000													11	63					0	0	0.000978	0	0
ATP8A1	10396	broad.mit.edu	37	4	42602537	42602537	+	Splice_Site	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:42602537T>A	ENST00000381668.5	-	6	641		c.e6-2		ATP8A1_ENST00000264449.10_Splice_Site	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	TTCTCAAAACTGGAAAGAGAA	0.333000													5	27					0	0	0.000602	0	0
USP10	9100	broad.mit.edu	37	16	84808830	84808830	+	Splice_Site	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:84808830A>T	ENST00000219473.7	+	13	2321	c.2209_splice	c.e13+1	p.A736_splice	USP10_ENST00000570191.1_Splice_Site_p.A740_splice	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	736					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						GGCTCTTTGCAGGTGAGTAAA	0.403000													19	58					0	0	0.001523	0	0
C2orf78	388960	broad.mit.edu	37	2	74041177	74041177	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:74041177C>G	ENST00000409561.1	+	2	792	c.671C>G	c.(670-672)tCc>tGc	p.S224C		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	224										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CCTCAACTATCCTGCCTGCAA	0.483000													18	74					0	0	0.006122	0	0
ITGAL	3683	broad.mit.edu	37	16	30518132	30518132	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:30518132G>C	ENST00000356798.6	+	21	2643	c.2463G>C	c.(2461-2463)ctG>ctC	p.L821L	ITGAL_ENST00000358164.5_Silent_p.L737L|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	821					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	AGCTGGACCTGCACTTCCCCC	0.602000													33	180					0	0	0.002836	0	0
FBXO3	26273	broad.mit.edu	37	11	33768856	33768856	+	Silent	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:33768856T>C	ENST00000530401.1	-	10	1064	c.1044A>G	c.(1042-1044)ccA>ccG	p.P348P	FBXO3_ENST00000526785.1_Silent_p.P240P|FBXO3_ENST00000531080.1_Silent_p.P40P|FBXO3_ENST00000534136.1_Silent_p.P353P|FBXO3_ENST00000532057.1_Silent_p.P40P|FBXO3_ENST00000448981.2_Silent_p.P353P|FBXO3_ENST00000265651.3_Silent_p.P353P			Q9UK99	FBX3_HUMAN	F-box protein 3	353	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		GGCTGATGATTGGAAATTCAC	0.343000													14	35					0	0	0.004007	0	0
ABCA2	20	broad.mit.edu	37	9	139913671	139913671	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:139913671C>T	ENST00000265662.5	-	11	1660	c.1513G>A	c.(1513-1515)Gag>Aag	p.E505K	ABCA2_ENST00000492260.1_5'UTR|ABCA2_ENST00000371605.3_Missense_Mutation_p.E504K|ABCA2_ENST00000341511.6_Missense_Mutation_p.E505K			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	504					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CTGCCCTGCTCCAGGAAGCTG	0.652000													6	31					0	0	0.001168	0	0
MUC20	200958	broad.mit.edu	37	3	195451995	195451995	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:195451995C>G	ENST00000320736.6	+	2	647	c.521C>G	c.(520-522)tCa>tGa	p.S174*	MUC20_ENST00000447234.2_Nonsense_Mutation_p.S174*|MUC20_ENST00000445522.2_Nonsense_Mutation_p.S139*|MUC20_ENST00000436408.1_Nonsense_Mutation_p.S174*	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	345	12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|Ser-rich.		Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		GGCCTGTCCTCAGAGAGCAGC	0.587000													19	133					0	0	0.001216	0	0
TSNARE1	203062	broad.mit.edu	37	8	143425409	143425409	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:143425409G>T	ENST00000524325.1	-	4	838	c.663C>A	c.(661-663)ctC>ctA	p.L221L	TSNARE1_ENST00000307180.3_Silent_p.L221L|TSNARE1_ENST00000519651.1_Intron|TSNARE1_ENST00000520166.1_Silent_p.L221L			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	221					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCACGGGCGTGAGAGCCAGGG	0.706000													10	41					1.33987e-11	3.10073e-11	0.000673	1	0
C17orf47	284083	broad.mit.edu	37	17	56620420	56620420	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:56620420G>C	ENST00000321691.3	-	1	1309	c.1128C>G	c.(1126-1128)acC>acG	p.T376T	RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	376										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGGTTTTTGGGTTTGCTGTT	0.493000													13	61					0	0	0.002450	0	0
UROC1	131669	broad.mit.edu	37	3	126220752	126220752	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:126220752G>T	ENST00000383579.3	-	10	975	c.942C>A	c.(940-942)gcC>gcA	p.A314A	UROC1_ENST00000290868.2_Intron	NM_001165974.1	NP_001159446.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	0					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CAGGGAGGCCGGCCCAGCCCA	0.647000													13	52					7.03913e-09	1.55388e-08	0.001368	1	0
ATP5G3	518	broad.mit.edu	37	2	176043799	176043799	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:176043799G>C	ENST00000284727.4	-	4	3324	c.300C>G	c.(298-300)atC>atG	p.I100M	ATP5G3_ENST00000409194.1_Missense_Mutation_p.I100M|ATP5G3_ENST00000392541.3_Missense_Mutation_p.I100M	NM_001002258.4|NM_001689.4	NP_001002258.1|NP_001680.1	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	100					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CATAACCAATGATAAGGCTGC	0.413000													11	42					0	0	0.001855	0	0
GABRQ	55879	broad.mit.edu	37	X	151820062	151820062	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:151820062C>G	ENST00000370306.2	+	8	995	c.975C>G	c.(973-975)atC>atG	p.I325M		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	325						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCTGTATCAAGGCCATTG	0.448000													33	84					0	0	0.002096	0	0
SEMA6B	10501	broad.mit.edu	37	19	4548323	4548323	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:4548323G>C	ENST00000586582.1	-	13	1716	c.1406C>G	c.(1405-1407)tCt>tGt	p.S469C	SEMA6B_ENST00000586965.1_Missense_Mutation_p.S469C|SEMA6B_ENST00000301293.3_Missense_Mutation_p.S469C	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	469	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGAGCCCAGACGTCCCTGA	0.647000													8	61					0	0	0.003080	0	0
PKD1L1	168507	broad.mit.edu	37	7	47913505	47913505	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:47913505G>A	ENST00000289672.2	-	24	3938	c.3888C>T	c.(3886-3888)ggC>ggT	p.G1296G		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1296	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						ACAGGTCCTCGCCCAGACAGT	0.502000													6	42					0	0	0.001168	0	0
PNOC	5368	broad.mit.edu	37	8	28196682	28196682	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:28196682C>T	ENST00000301908.3	+	3	460	c.252C>T	c.(250-252)ctC>ctT	p.L84L	PNOC_ENST00000522209.1_Silent_p.L20L|RP11-380I10.4_ENST00000521731.1_RNA	NM_006228.3	NP_006219.1	Q13519	PNOC_HUMAN	prepronociceptin	84					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	5		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		CGGCTGCTCTCTACCAGCCGA	0.652000													12	63					0	0	0.001368	0	0
VPS13B	157680	broad.mit.edu	37	8	100831006	100831006	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:100831006G>A	ENST00000358544.2	+	47	8697	c.8586G>A	c.(8584-8586)gaG>gaA	p.E2862E	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.E2837E	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2862					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TACATTTGGAGAAAAGGAGTC	0.373000													15	111					0	0	0.004007	0	0
FLG	2312	broad.mit.edu	37	1	152277553	152277553	+	Missense_Mutation	SNP	C	C	T	rs147429418	byFrequency	TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:152277553C>T	ENST00000368799.1	-	3	9844	c.9809G>A	c.(9808-9810)cGc>cAc	p.R3270H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3270	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTCTGGAGCGGTCTGCAGA	0.577000									Ichthyosis				93	380					0	0	0.003610	0	0
TTC8	123016	broad.mit.edu	37	14	89305909	89305909	+	Silent	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:89305909A>G	ENST00000338104.6	+	2	280	c.228A>G	c.(226-228)caA>caG	p.Q76Q	TTC8_ENST00000345383.5_Silent_p.Q76Q|TTC8_ENST00000380656.2_Silent_p.Q86Q|TTC8_ENST00000346301.4_Silent_p.Q76Q|TTC8_ENST00000536576.1_5'UTR|TTC8_ENST00000354441.6_Intron			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	86					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CTATAGCTCAAGTTCCACGTA	0.328000													6	45					0	0	0.004482	0	0
HTR1A	3350	broad.mit.edu	37	5	63256365	63256365	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:63256365C>A	ENST00000323865.3	-	1	1415	c.1182G>T	c.(1180-1182)ctG>ctT	p.L394L	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	394					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CGGGGTTAAGCAGAGAGTTGG	0.498000													47	159					4.01344e-20	9.8535e-20	0.003610	1	0
TEX15	56154	broad.mit.edu	37	8	30695362	30695362	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:30695362T>A	ENST00000256246.2	-	3	7363	c.7289A>T	c.(7288-7290)gAa>gTa	p.E2430V		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2430										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATTTAAATTTTCCTGTTGTCC	0.358000													39	157					0	0	0.005524	0	0
SNTG1	54212	broad.mit.edu	37	8	51617301	51617301	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:51617301G>A	ENST00000522124.1	+	16	1841	c.1180G>A	c.(1180-1182)Gaa>Aaa	p.E394K	SNTG1_ENST00000276467.5_Missense_Mutation_p.E394K|SNTG1_ENST00000517473.1_Missense_Mutation_p.E394K|SNTG1_ENST00000518864.1_Missense_Mutation_p.E394K	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	394					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCTAGAAGTAGAACGGATACA	0.507000													4	31					0	0	0.000248	0	0
SSPO	23145	broad.mit.edu	37	7	149486333	149486333	+	RNA	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:149486333C>A	ENST00000378016.2	+	0	4309							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTCTGTGACCGCCAGGATGA	0.687000													6	29					0.00198382	0.00390644	0.001984	1	0
WWC3	55841	broad.mit.edu	37	X	10106854	10106854	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:10106854T>A	ENST00000380861.4	+	21	3353	c.2962T>A	c.(2962-2964)Tgc>Agc	p.C988S	WWC3_ENST00000454666.1_Missense_Mutation_p.C988S	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	988										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						TGAGGAGCTCTGCGCCCTCCG	0.677000													7	28					0	0	0.001984	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29686564	29686564	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:29686564C>T	ENST00000378993.1	+	6	1394	c.721C>T	c.(721-723)Cca>Tca	p.P241S	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.P241S	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	241					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GACTGATAAGCCACCCAAGCT	0.368000													4	32					0	0	0.001168	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320154	79320154	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:79320154C>A	ENST00000428286.1	-	8	7159	c.5959G>T	c.(5959-5961)Gaa>Taa	p.E1987*	PRUNE2_ENST00000376718.3_Nonsense_Mutation_p.E2346*			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2346					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CACGAGGCTTCAGATGAGCAG	0.473000													32	133					9.65021e-13	2.27448e-12	0.002096	1	0
PARP8	79668	broad.mit.edu	37	5	50092850	50092850	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:50092850G>A	ENST00000281631.5	+	13	1621	c.1463G>A	c.(1462-1464)cGt>cAt	p.R488H	PARP8_ENST00000505697.2_Missense_Mutation_p.R488H|PARP8_ENST00000503750.2_Missense_Mutation_p.R488H|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000514342.2_Missense_Mutation_p.R241H|PARP8_ENST00000514067.2_Missense_Mutation_p.R488H|PARP8_ENST00000505554.1_Missense_Mutation_p.R467H	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	488						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				GTACGAGACCGTGGCTTCCTG	0.308000													8	20					0	0	0.004482	0	0
OR51G1	79324	broad.mit.edu	37	11	4945474	4945474	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:4945474G>T	ENST00000321961.2	-	1	163	c.96C>A	c.(94-96)ccC>ccA	p.P32P	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAAGCAGAAGGGAATAGAGA	0.468000													11	50					1.33987e-11	3.10073e-11	0.000673	1	0
MB21D2	151963	broad.mit.edu	37	3	192516720	192516720	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:192516720G>C	ENST00000392452.2	-	2	1251	c.931C>G	c.(931-933)Cag>Gag	p.Q311E		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	311								p.Q309E(2)		endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						TTGCAGGCCTGATAGGCCTGC	0.557000													3	73					0	0	0.000248	0	0
ATP2A2	488	broad.mit.edu	37	12	110784230	110784230	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:110784230G>T	ENST00000395494.2	+	19	3566	c.3003G>T	c.(3001-3003)tgG>tgT	p.W1001C	ATP2A2_ENST00000308664.6_Intron|ATP2A2_ENST00000539276.2_Missense_Mutation_p.W1028C			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	1028					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						TGGTGATCTGGGTCTATAGCA	0.433000													6	31					0.00198382	0.00390644	0.001984	1	0
PARD3	56288	broad.mit.edu	37	10	34420402	34420402	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:34420402C>G	ENST00000374789.3	-	23	3863	c.3538G>C	c.(3538-3540)Gag>Cag	p.E1180Q	PARD3_ENST00000374794.3_Missense_Mutation_p.E1068Q|PARD3_ENST00000374790.3_Missense_Mutation_p.E1120Q|PARD3_ENST00000350537.4_Missense_Mutation_p.E1134Q|PARD3_ENST00000545693.1_Missense_Mutation_p.E1164Q|PARD3_ENST00000374788.3_Missense_Mutation_p.E1177Q|PARD3_ENST00000545260.1_Missense_Mutation_p.E1090Q|PARD3_ENST00000346874.4_Missense_Mutation_p.E1143Q	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1180					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CAGGGTTGCTCAAAACTATAG	0.458000													4	47					0	0	0.000248	0	0
IGKV1-16	28938	broad.mit.edu	37	2	89399636	89399636	+	RNA	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:89399636C>T	ENST00000479981.1	-	0	93																											ATCTGGATGTCACATCTGGCA	0.443000													17	147					0	0	0.003330	0	0
ST18	9705	broad.mit.edu	37	8	53073977	53073977	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:53073977T>A	ENST00000276480.7	-	14	2235	c.1552A>T	c.(1552-1554)Ata>Tta	p.I518L		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	518						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ACTGTTTGTATGAGAGGGCGT	0.428000													24	78					0	0	0.003330	0	0
LILRA1	11024	broad.mit.edu	37	19	55106219	55106219	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:55106219G>A	ENST00000453777.1	+	4	330	c.160G>A	c.(160-162)Gag>Aag	p.E54K	LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000251372.3_Missense_Mutation_p.E54K|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396321.2_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	54	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GGGGATCCTGGAGACCCAGGA	0.577000													19	91					0	0	0.006122	0	0
CLK2	1196	broad.mit.edu	37	1	155240769	155240769	+	Splice_Site	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:155240769C>G	ENST00000368361.4	-	2	316		c.e2-1		CLK2_ENST00000361168.5_Splice_Site|CLK2_ENST00000355560.4_Splice_Site|CLK2_ENST00000536801.1_Splice_Site			P49760	CLK2_HUMAN	CDC-like kinase 2							nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GATGCGGCATCTGGAAGGCAA	0.527000								Other conserved DNA damage response genes					16	144					0	0	0.004007	0	0
TRPC5	7224	broad.mit.edu	37	X	111097124	111097124	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:111097124T>A	ENST00000262839.2	-	4	2029	c.1111A>T	c.(1111-1113)Aca>Tca	p.T371S		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	371					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TAGGATGCTGTGTGGCAGATA	0.498000													25	66					0	0	0.003330	0	0
APOBEC2	10930	broad.mit.edu	37	6	41029282	41029282	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:41029282G>A	ENST00000244669.2	+	2	391	c.347G>A	c.(346-348)cGg>cAg	p.R116Q		NM_006789.3	NP_006780.1	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	116					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding	p.R116Q(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)	10	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCAGCCCTGCGGTACAATGTC	0.562000													13	155					0	0	0.001368	0	0
PARVG	64098	broad.mit.edu	37	22	44585010	44585010	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:44585010C>T	ENST00000422871.1	+	6	688	c.264C>T	c.(262-264)ctC>ctT	p.L88L	PARVG_ENST00000444313.2_Silent_p.L88L|PARVG_ENST00000415224.1_Silent_p.L88L	NM_001137605.1	NP_001131077.1	Q9HBI0	PARVG_HUMAN	parvin, gamma	88	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				TGGCGGCGCTCAAGCTGGAAG	0.652000													5	61					0	0	0.000602	0	0
ITGA8	8516	broad.mit.edu	37	10	15655677	15655677	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:15655677G>C	ENST00000378076.3	-	15	1888	c.1535C>G	c.(1534-1536)tCt>tGt	p.S512C		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	512					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						AGATGTCATAGAGTCTGGAAC	0.453000													17	112					0	0	0.006122	0	0
KCNK18	338567	broad.mit.edu	37	10	118969465	118969465	+	Silent	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:118969465T>C	ENST00000334549.1	+	3	810	c.810T>C	c.(808-810)gaT>gaC	p.D270D		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	270						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GCAACCTGGATGAAGTTGGAC	0.527000													18	93					0	0	0.006122	0	0
LINGO1	84894	broad.mit.edu	37	15	77906424	77906424	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:77906424C>A	ENST00000355300.6	-	2	1999	c.1825G>T	c.(1825-1827)Gcc>Tcc	p.A609S	LINGO1_ENST00000561030.1_Missense_Mutation_p.A603S	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	609					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						GGCGCGTCGGCGGAGCTGATG	0.672000													10	15					2.17888e-05	4.53538e-05	0.000443	1	0
PCDHB18P	54660	broad.mit.edu	37	5	140616044	140616044	+	RNA	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:140616044C>A	ENST00000526308.1	+	0	2107					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						CAAGCACAGGCTGGTGGTGCT	0.706000													15	50					8.60227e-14	2.04638e-13	0.004007	1	0
MTR	4548	broad.mit.edu	37	1	236979822	236979822	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:236979822T>A	ENST00000366577.5	+	8	1137	c.743T>A	c.(742-744)gTg>gAg	p.V248E	MTR_ENST00000418145.2_3'UTR|MTR_ENST00000535889.1_Missense_Mutation_p.V248E	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	248	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GTCATCAGCGTGTCTCATGGA	0.458000													26	101					0	0	0.001271	0	0
FAM135B	51059	broad.mit.edu	37	8	139155262	139155262	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:139155262G>T	ENST00000395297.1	-	16	3801	c.3631C>A	c.(3631-3633)Cga>Aga	p.R1211R		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1211										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCTAATTCGGGATATGGAG	0.398000										HNSCC(54;0.14)			4	32					1.23904e-05	2.59318e-05	0.000602	1	0
ADCY2	108	broad.mit.edu	37	5	7717278	7717278	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:7717278C>A	ENST00000338316.4	+	12	1720	c.1631C>A	c.(1630-1632)tCa>tAa	p.S544*	ADCY2_ENST00000537121.1_Nonsense_Mutation_p.S364*|RP11-711G10.1_ENST00000514105.2_RNA	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	544					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						AGAACCAAGTCACAAAAGAAG	0.269000													5	50					8.12818e-05	0.00016559	0.001984	1	0
RARRES2	5919	broad.mit.edu	37	7	150036164	150036164	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:150036164G>C	ENST00000466675.1	-	3	1319	c.286C>G	c.(286-288)Cgg>Ggg	p.R96G	RARRES2_ENST00000482669.1_Missense_Mutation_p.R96G|RARRES2_ENST00000223271.3_Missense_Mutation_p.R96G			Q99969	RARR2_HUMAN	retinoic acid receptor responder (tazarotene induced) 2	96					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			endometrium(1)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGGCATTTCCGTTTCCTCTGT	0.617000													18	76					0	0	0.006122	0	0
FAM208B	54906	broad.mit.edu	37	10	5799599	5799599	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:5799599G>A	ENST00000328090.5	+	17	7474	c.6849G>A	c.(6847-6849)gtG>gtA	p.V2283V		NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	2283																	GAGGCTTTGTGATATCAGATG	0.428000													6	155					0	0	0.001984	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874270	74874270	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:74874270C>T	ENST00000331628.3	-	4	932	c.685G>A	c.(685-687)Gca>Aca	p.A229T	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.A229T	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	229					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						ATGTAAGCTGCCAGAGCCACC	0.652000													17	68					0	0	0.004007	0	0
CTNNA2	1496	broad.mit.edu	37	2	80097015	80097015	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:80097015G>T	ENST00000466387.1	+	9	1263	c.539G>T	c.(538-540)gGg>gTg	p.G180V	CTNNA2_ENST00000496558.1_Missense_Mutation_p.G180V|CTNNA2_ENST00000541047.1_Missense_Mutation_p.G180V|CTNNA2_ENST00000540488.1_Missense_Mutation_p.G180V|CTNNA2_ENST00000361291.4_Missense_Mutation_p.G214V|CTNNA2_ENST00000402739.4_Missense_Mutation_p.G180V			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	180					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAAGAGTTTGGGAAAGAGATG	0.403000													8	52					5.4927e-09	1.21601e-08	0.004482	1	0
FUT9	10690	broad.mit.edu	37	6	96651727	96651727	+	Silent	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:96651727T>C	ENST00000302103.5	+	3	1022	c.696T>C	c.(694-696)atT>atC	p.I232I		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	232					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AAAATTTGATTCCTACCATAT	0.358000													5	21					0	0	0.000602	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344884	38344884	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:38344884G>A	ENST00000374618.3	+	5	2010	c.1832G>A	c.(1831-1833)tGt>tAt	p.C611Y	ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000307441.9_Missense_Mutation_p.C610Y|ZNF33A_ENST00000432900.2_Missense_Mutation_p.C617Y|ZNF33A_ENST00000458705.2_Missense_Mutation_p.C610Y	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	610						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						CCCTATGAATGTAATGAATGT	0.363000													11	58					0	0	0.000978	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100672232	100672232	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:100672232C>G	ENST00000268070.4	-	12	1806	c.1701G>C	c.(1699-1701)caG>caC	p.Q567H		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	567	TSP type-1 1.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CACATTTCCTCTGCCTGAAGC	0.627000											OREG0023513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	79					0	0	0.003080	0	0
MPDZ	8777	broad.mit.edu	37	9	13168483	13168483	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:13168483C>A	ENST00000319217.7	-	22	3383	c.3136G>T	c.(3136-3138)Ggc>Tgc	p.G1046C	MPDZ_ENST00000447879.1_Missense_Mutation_p.G1046C|MPDZ_ENST00000381022.2_Missense_Mutation_p.G1046C|MPDZ_ENST00000536827.1_Missense_Mutation_p.G1046C|MPDZ_ENST00000541718.1_Missense_Mutation_p.G1046C|MPDZ_ENST00000546205.1_Missense_Mutation_p.G1046C|MPDZ_ENST00000381015.4_Missense_Mutation_p.G1046C	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1046	PDZ 6.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GCAATCCGGCCATCTCGACTA	0.453000													113	129					1.22118e-62	3.06695e-62	0.003610	1	0
FRZB	2487	broad.mit.edu	37	2	183731215	183731215	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:183731215G>A	ENST00000295113.4	-	1	675	c.66C>T	c.(64-66)ctC>ctT	p.L22L		NM_001463.3	NP_001454.2	Q92765	SFRP3_HUMAN	frizzled-related protein	22					brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GGAGCAGGCAGAGAGCAGCCA	0.706000													4	5					0	0	0.001984	0	0
AKAP9	10142	broad.mit.edu	37	7	91730347	91730347	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:91730347G>C	ENST00000359028.2	+	45	11311	c.11086G>C	c.(11086-11088)Gat>Cat	p.D3696H	AKAP9_ENST00000358100.2_Missense_Mutation_p.D3642H|AKAP9_ENST00000356239.3_Missense_Mutation_p.D3692H			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3696					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCTGAGCCCTGATTCTGAACA	0.383000			T	BRAF	papillary thyroid								7	29					0	0	0.003080	0	0
OR4E2	26686	broad.mit.edu	37	14	22133982	22133982	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:22133982C>G	ENST00000408935.1	+	1	686	c.686C>G	c.(685-687)tCa>tGa	p.S229*		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CGAAAACACTCAGCTGAAGGG	0.517000													11	64					0	0	0.000673	0	0
HSPA8	3312	broad.mit.edu	37	11	122930370	122930370	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:122930370G>A	ENST00000534624.1	-	5	1207	c.931C>T	c.(931-933)Cgt>Tgt	p.R311C	HSPA8_ENST00000227378.3_Missense_Mutation_p.R311C|HSPA8_ENST00000534319.1_Missense_Mutation_p.R75C|HSPA8_ENST00000533540.1_Missense_Mutation_p.R165C|HSPA8_ENST00000532636.1_Missense_Mutation_p.R311C|HSPA8_ENST00000526862.1_5'UTR|HSPA8_ENST00000453788.2_Missense_Mutation_p.R311C|HSPA8_ENST00000526110.1_Missense_Mutation_p.R292C	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	311	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGGGTGCCACGGAACAGGTCA	0.488000													17	39					0	0	0.006122	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563947	140563947	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:140563947C>A	ENST00000361016.2	+	1	2968	c.1813C>A	c.(1813-1815)Cag>Aag	p.Q605K		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		605	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGTCGTACCAGCTGCTCAA	0.706000													35	101					2.87052e-16	6.91452e-16	0.005524	1	0
FAM13A	10144	broad.mit.edu	37	4	89668809	89668809	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:89668809C>A	ENST00000264344.5	-	18	2562	c.2355G>T	c.(2353-2355)gcG>gcT	p.A785A	FAM13A_ENST00000513837.1_Silent_p.A431A|FAM13A_ENST00000508369.1_Silent_p.A459A|FAM13A_ENST00000395002.2_Silent_p.A459A|FAM13A_ENST00000511976.1_Silent_p.A371A|FAM13A_ENST00000503556.1_Silent_p.A445A	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	785					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						GGCTGCTTTCCGCTCGCTTCT	0.498000													25	141					3.73988e-18	9.09445e-18	0.001061	1	0
ZNF831	128611	broad.mit.edu	37	20	57767508	57767508	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:57767508C>G	ENST00000371030.2	+	1	1434	c.1434C>G	c.(1432-1434)gaC>gaG	p.D478E		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	478						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CGCCCCCAGACAAGTCTCGGC	0.662000													13	47					0	0	0.001855	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900413	151900413	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:151900413A>T	ENST00000393900.3	-	3	741	c.388T>A	c.(388-390)Ttc>Atc	p.F130I	CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.F130I|MAGEA12_ENST00000357916.4_Missense_Mutation_p.F130I	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	130	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GCCTTTGTGAATGGCTCCCTG	0.498000													47	117					0	0	0.003610	0	0
CSMD1	64478	broad.mit.edu	37	8	3256980	3256980	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:3256980C>G	ENST00000602557.1	-	17	2896	c.2341G>C	c.(2341-2343)Gat>Cat	p.D781H	CSMD1_ENST00000602723.1_Missense_Mutation_p.D781H|CSMD1_ENST00000542608.1_Missense_Mutation_p.D780H|CSMD1_ENST00000537824.1_Missense_Mutation_p.D780H|CSMD1_ENST00000539096.1_Missense_Mutation_p.D780H|CSMD1_ENST00000400186.3_Missense_Mutation_p.D781H|CSMD1_ENST00000520002.1_Missense_Mutation_p.D781H			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	781	CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTAAAGAATCCTTATAATAT	0.388000													12	48					0	0	0.000978	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562680	140562680	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:140562680C>T	ENST00000361016.2	+	1	1701	c.546C>T	c.(544-546)atC>atT	p.I182I		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		182	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGTTCTAATCCATGAATTCA	0.458000													12	33					0	0	0.001368	0	0
ERN1	2081	broad.mit.edu	37	17	62122729	62122729	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:62122729G>A	ENST00000433197.2	-	20	2738	c.2643C>T	c.(2641-2643)ccC>ccT	p.P881P		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	881	KEN.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CTGTCTGGAGGGGGACAGTGA	0.562000													6	37					0	0	0.001168	0	0
CPXM1	56265	broad.mit.edu	37	20	2775946	2775946	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:2775946C>A	ENST00000380605.2	-	12	1901	c.1837G>T	c.(1837-1839)Gcc>Tcc	p.A613S		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	613					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding	p.A613P(1)		endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GTGAGGAGGGCGTCTTTGTTG	0.572000													6	43					8.12818e-05	0.00016559	0.001984	1	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5653889	5653889	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:5653889G>T	ENST00000354852.5	+	8	1563	c.1390G>T	c.(1390-1392)Gag>Tag	p.E464*	TRIM34_ENST00000429814.2_Nonsense_Mutation_p.E110*|TRIM6-TRIM34_ENST00000457787.2_Nonsense_Mutation_p.E110*|TRIM34_ENST00000514226.1_Nonsense_Mutation_p.E110*|HBG2_ENST00000380259.2_Intron	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		464						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CTTCTGTAAGGAGGATAGGAA	0.493000													4	23					0.00024832	0.000504544	0.000248	1	0
DGKA	1606	broad.mit.edu	37	12	56332340	56332340	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:56332340G>C	ENST00000331886.5	+	6	849	c.395G>C	c.(394-396)aGc>aCc	p.S132T	DGKA_ENST00000551156.1_Missense_Mutation_p.S132T|DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000394147.1_Missense_Mutation_p.S132T	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	132	EF-hand 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	ATCCTGGACAGCTCAGTGAGT	0.507000													29	122					0	0	0.001512	0	0
IER5	51278	broad.mit.edu	37	1	181058479	181058479	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:181058479G>C	ENST00000367577.4	+	1	842	c.441G>C	c.(439-441)ccG>ccC	p.P147P		NM_016545.4	NP_057629.2	Q5VY09	IER5_HUMAN	immediate early response 5	147										lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	4						TGGAGGGGCCGCGCCAGGCGG	0.746000													3	9					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179579978	179579978	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:179579978G>A	ENST00000589042.1	-	90	26159	c.25935C>T	c.(25933-25935)ttC>ttT	p.F8645F	TTN_ENST00000591111.1_Silent_p.F8328F|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Silent_p.F7401F|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8328	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTTTTGCGGAAAATGGGTG	0.388000													19	43					0	0	0.006122	0	0
HSPG2	3339	broad.mit.edu	37	1	22157584	22157584	+	Splice_Site	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:22157584C>G	ENST00000374695.3	-	85	11642		c.e85-1			NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2						angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding	p.?(1)		breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GACCGCCATTCTGCAAAGCAG	0.637000													3	18					0	0	0.004672	0	0
CLCN4	1183	broad.mit.edu	37	X	10176392	10176392	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:10176392C>G	ENST00000380833.4	+	9	1542	c.1151C>G	c.(1150-1152)gCc>gGc	p.A384G	CLCN4_ENST00000380829.1_Missense_Mutation_p.A353G|CLCN4_ENST00000421085.2_Missense_Mutation_p.A290G	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	384						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCCATCATTGCCTACCCCAAT	0.577000													47	261					0	0	0.003610	0	0
CSMD2	114784	broad.mit.edu	37	1	34092182	34092182	+	Splice_Site	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:34092182C>T	ENST00000373381.4	-	33	5377		c.e33-1		CSMD2_ENST00000373388.2_Splice_Site|CSMD2_ENST00000373380.1_Splice_Site|CSMD2_ENST00000373377.1_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGTGATTCTCCTGCCGAGATA	0.557000													5	11					0	0	0.000602	0	0
GPRC5C	55890	broad.mit.edu	37	17	72443133	72443133	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:72443133C>G	ENST00000392627.1	+	4	2553	c.1427C>G	c.(1426-1428)tCt>tGt	p.S476C	GPRC5C_ENST00000392629.2_Missense_Mutation_p.S443C|GPRC5C_ENST00000582873.1_3'UTR|GPRC5C_ENST00000481232.1_3'UTR|GPRC5C_ENST00000342648.5_Missense_Mutation_p.S116C	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	431						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding	p.S443C(1)|p.S476C(1)		central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						GGCAAGAACTCTCAGGTCTTT	0.652000													16	91					0	0	0.006122	0	0
FKBP3	2287	broad.mit.edu	37	14	45590112	45590112	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:45590112C>G	ENST00000216330.3	-	6	910	c.500G>C	c.(499-501)gGa>gCa	p.G167A	FKBP3_ENST00000396062.3_Missense_Mutation_p.G167A			Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	167	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity			NS(1)|biliary_tract(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	12						TTTGCCTACTCCGACCTTAAA	0.333000													3	61					0	0	0.000248	0	0
ATP8A2	51761	broad.mit.edu	37	13	26154054	26154054	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:26154054G>T	ENST00000381655.2	+	22	2118	c.1976G>T	c.(1975-1977)cGg>cTg	p.R659L	ATP8A2_ENST00000255283.8_Missense_Mutation_p.R619L|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	619					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGAGCTCAACGGTTGGAAGAG	0.438000													13	28					2.61681e-11	6.01946e-11	0.002450	1	0
MAPRE3	22924	broad.mit.edu	37	2	27247054	27247054	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:27247054G>C	ENST00000233121.2	+	4	556	c.358G>C	c.(358-360)Gat>Cat	p.D120H	MAPRE3_ENST00000402218.1_Missense_Mutation_p.D120H|MAPRE3_ENST00000405074.3_Missense_Mutation_p.D120H			Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family, member 3	120					cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|upper_aerodigestive_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCAAACTATGATGGAAAGGA	0.413000													7	34					0	0	0.004482	0	0
NR1H4	9971	broad.mit.edu	37	12	100955661	100955661	+	Splice_Site	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:100955661A>T	ENST00000548884.1	+	10	1607		c.e10-1		NR1H4_ENST00000188403.7_Splice_Site|NR1H4_ENST00000392986.3_Splice_Site|NR1H4_ENST00000551379.1_Splice_Site|NR1H4_ENST00000549996.1_Splice_Site	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4						bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TTTCCCCCACAGGTATCTCTG	0.318000													11	17					0	0	0.000673	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43654256	43654256	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:43654256G>T	ENST00000374466.3	+	3	1090	c.755G>T	c.(754-756)cGc>cTc	p.R252L	CSGALNACT2_ENST00000374464.1_Missense_Mutation_p.R252L	NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	252					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						ACCCTCTTCCGCCCTTTTGGA	0.393000													11	50					3.07112e-06	6.48065e-06	0.000978	1	0
CERK	64781	broad.mit.edu	37	22	47095335	47095335	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:47095335G>T	ENST00000216264.8	-	8	930	c.818C>A	c.(817-819)tCa>tAa	p.S273*	CERK_ENST00000541677.1_Nonsense_Mutation_p.S75*	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	273	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GTGGTGGACTGAGGACACATC	0.612000													16	113					1.15088e-07	2.49032e-07	0.004007	1	0
TTLL6	284076	broad.mit.edu	37	17	46867429	46867429	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:46867429C>T	ENST00000393382.3	-	10	1405	c.1264G>A	c.(1264-1266)Gat>Aat	p.D422N	TTLL6_ENST00000433608.2_Missense_Mutation_p.D115N	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	374						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						ACCTCTTTATCCAACCGAGAG	0.512000													19	68					0	0	0.001523	0	0
EGFR	1956	broad.mit.edu	37	7	55221793	55221793	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:55221793G>A	ENST00000275493.2	+	7	1014	c.837G>A	c.(835-837)gtG>gtA	p.V279V	EGFR_ENST00000455089.1_Silent_p.V234V|EGFR_ENST00000342916.3_Silent_p.V279V|EGFR_ENST00000454757.2_Silent_p.V226V|EGFR_ENST00000344576.2_Silent_p.V279V|EGFR_ENST00000420316.2_Silent_p.V279V|EGFR_ENST00000442591.1_Silent_p.V279V	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	279					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGATGGATGTGAACCCCGAGG	0.587000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			7	67					0	0	0.001984	0	0
CYP4F3	4051	broad.mit.edu	37	19	15754740	15754740	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:15754740G>A	ENST00000591058.1	+	3	269	c.222G>A	c.(220-222)atG>atA	p.M74I	CYP4F3_ENST00000221307.7_Intron|CYP4F3_ENST00000585846.1_Missense_Mutation_p.M74I|CYP4F3_ENST00000586182.1_Missense_Mutation_p.M74I	NM_001199208.1|NM_001199209.1	NP_001186137.1|NP_001186138.1	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	74					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						AGCAGGGCATGAGGGTCCTGA	0.597000													7	25					0	0	0.001984	0	0
VPS13B	157680	broad.mit.edu	37	8	100831079	100831079	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:100831079G>A	ENST00000358544.2	+	47	8770	c.8659G>A	c.(8659-8661)Gaa>Aaa	p.E2887K	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.E2862K	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2887					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCAAAACATAGAACCTGACCT	0.378000													13	67					0	0	0.001855	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525600	176525600	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:176525600G>C	ENST00000367662.3	+	2	1306	c.142G>C	c.(142-144)Gaa>Caa	p.E48Q	PAPPA2_ENST00000367661.3_Missense_Mutation_p.E48Q	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	48					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTTGGAAGGAGAACGTTGTTG	0.572000													17	98					0	0	0.004990	0	0
ADCY3	109	broad.mit.edu	37	2	25050956	25050956	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:25050956C>T	ENST00000260600.5	-	13	3098	c.2247G>A	c.(2245-2247)gaG>gaA	p.E749E	ADCY3_ENST00000450524.1_5'UTR|ADCY3_ENST00000405392.1_Intron	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	749					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					ACTTGGGGTTCTCCAGGCAGC	0.607000											OREG0014498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	36					0	0	0.001168	0	0
SART1	9092	broad.mit.edu	37	11	65744017	65744017	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:65744017G>A	ENST00000312397.5	+	13	1816	c.1724G>A	c.(1723-1725)cGc>cAc	p.R575H		NM_005146.4	NP_005137.1	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T cells	575					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GCTGGCAATCGCGAGGAGCAG	0.687000													8	39					0	0	0.003080	0	0
KAT6A	7994	broad.mit.edu	37	8	41798738	41798738	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:41798738G>C	ENST00000396930.3	-	16	3204	c.2661C>G	c.(2659-2661)ctC>ctG	p.L887L	KAT6A_ENST00000265713.2_Silent_p.L887L|KAT6A_ENST00000406337.1_Silent_p.L887L	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	887					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCTCTTCCAAGAGCAGTTTAG	0.483000													14	58					0	0	0.001855	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890179	23890179	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:23890179G>A	ENST00000532292.1	-	1	996	c.902C>T	c.(901-903)gCc>gTc	p.A301V		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GTCATGAAAGGCTAGCGTGTG	0.627000													18	46					0	0	0.006122	0	0
CHST8	64377	broad.mit.edu	37	19	34263714	34263714	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:34263714G>A	ENST00000262622.3	+	4	1779	c.1021G>A	c.(1021-1023)Gac>Aac	p.D341N	CHST8_ENST00000434302.1_Missense_Mutation_p.D341N|CHST8_ENST00000438847.2_Missense_Mutation_p.D341N	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	341					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					CTGCCTCATCGACTACGATTT	0.607000													13	34					0	0	0.001855	0	0
ZNF668	79759	broad.mit.edu	37	16	31073227	31073227	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:31073227C>T	ENST00000538906.1	-	3	1806	c.1022G>A	c.(1021-1023)tGt>tAt	p.C341Y	ZNF668_ENST00000300849.4_Missense_Mutation_p.C341Y|ZNF668_ENST00000539836.3_Missense_Mutation_p.C364Y|ZNF668_ENST00000535577.1_Missense_Mutation_p.C341Y|ZNF668_ENST00000426488.2_Missense_Mutation_p.C364Y|ZNF668_ENST00000394983.2_Missense_Mutation_p.C341Y|ZNF668_ENST00000417110.2_Missense_Mutation_p.H139Y	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						CGTCTTGTCACATTGCAGGCA	0.677000													13	59					0	0	0.004007	0	0
NEK11	79858	broad.mit.edu	37	3	130828653	130828653	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:130828653G>A	ENST00000383366.4	+	5	636	c.343G>A	c.(343-345)Gat>Aat	p.D115N	NEK11_ENST00000429253.2_Missense_Mutation_p.D115N|NEK11_ENST00000510688.1_Missense_Mutation_p.D115N|NEK11_ENST00000412440.2_5'UTR|NEK11_ENST00000507910.1_Missense_Mutation_p.D115N|NEK11_ENST00000511262.1_Missense_Mutation_p.D115N|NEK11_ENST00000508196.1_Missense_Mutation_p.D115N|NEK11_ENST00000356918.4_Missense_Mutation_p.D115N|NEK11_ENST00000510769.1_Missense_Mutation_p.D115N|NEK11_ENST00000426022.2_3'UTR	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	115	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						TCAGGGCCGAGATCTGGACGA	0.333000													8	101					0	0	0.004482	0	0
MS4A5	64232	broad.mit.edu	37	11	60215208	60215208	+	Silent	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:60215208T>C	ENST00000300190.2	+	5	665	c.579T>C	c.(577-579)gaT>gaC	p.D193D		NM_023945.2	NP_076434.2	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member 5	193						integral to membrane	receptor activity			large_intestine(7)|lung(7)|ovary(1)|skin(1)	16						ACTCAGAGGATTGTGATTGTG	0.353000													16	88					0	0	0.004007	0	0
C9orf135	138255	broad.mit.edu	37	9	72435949	72435949	+	Splice_Site	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:72435949T>A	ENST00000377197.3	+	1	239		c.e1+2		C9orf135_ENST00000466872.2_Splice_Site|C9orf135_ENST00000527647.1_Splice_Site	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135							integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						GTATTCCTGGTGAGCGAAGTC	0.587000													10	39					0	0	0.000673	0	0
CEP112	201134	broad.mit.edu	37	17	64059084	64059084	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:64059084T>A	ENST00000392769.2	-	11	1289	c.1071A>T	c.(1069-1071)aaA>aaT	p.K357N	CEP112_ENST00000535342.2_Missense_Mutation_p.K357N|CEP112_ENST00000541355.1_5'UTR|CEP112_ENST00000537949.1_Missense_Mutation_p.K315N	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	357						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						AGCTTACCTTTTTTTCCCAGT	0.299000													7	35					0	0	0.004482	0	0
TRBC2	28638	broad.mit.edu	37	7	142499028	142499028	+	RNA	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:142499028G>A	ENST00000466254.1	+	0	304																											CAGTTCTACGGGCTCTCGGAG	0.627000													17	104					0	0	0.001523	0	0
RAB11FIP2	22841	broad.mit.edu	37	10	119768713	119768713	+	Silent	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:119768713A>T	ENST00000355624.3	-	5	1774	c.1335T>A	c.(1333-1335)acT>acA	p.T445T	RAB11FIP2_ENST00000369199.3_Silent_p.T465T|RAB11FIP2_ENST00000476207.1_5'UTR	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	445	FIP-RBD.				protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		GATACCCTGCAGTGGCATCAA	0.458000													25	73					0	0	0.004656	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641925	106641925	+	RNA	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:106641925C>T	ENST00000390605.2	-	0	105																											GTTTCTCTCTCAGCCCTGGGA	0.577000													11	68					0	0	0.000673	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104984567	104984567	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:104984567G>C	ENST00000372582.1	+	8	1687	c.931G>C	c.(931-933)Gaa>Caa	p.E311Q	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E311Q	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	311	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGGAGAAAAAGAAGTTGAATT	0.443000													12	61					0	0	0.001368	0	0
ACTN2	88	broad.mit.edu	37	1	236900470	236900470	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:236900470G>C	ENST00000366578.4	+	9	998	c.832G>C	c.(832-834)Gag>Cag	p.E278Q	ACTN2_ENST00000542672.1_Missense_Mutation_p.E278Q|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_5'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	278					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGTGAATCAAGAGAATGAGAG	0.512000													7	45					0	0	0.003080	0	0
IGKV4-1	28908	broad.mit.edu	37	2	89185464	89185464	+	RNA	SNP	C	C	G	rs139176691	by1000genomes	TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:89185464C>G	ENST00000390243.2	+	0	333																											TTATACAGCTCCAACAATAAG	0.547000													6	37					0	0	0.001168	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37440991	37440991	+	Missense_Mutation	SNP	C	C	T	rs45515098		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:37440991C>T	ENST00000374660.1	+	12	1580	c.1481C>T	c.(1480-1482)cCg>cTg	p.P494L	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.P494L|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.P494L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	550						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TTTATAGATCCGATGTTCCCA	0.294000													9	43					0	0	0.001368	0	0
KLRF1	51348	broad.mit.edu	37	12	9984956	9984956	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:9984956T>C	ENST00000279544.3	+	2	194	c.130T>C	c.(130-132)Tct>Cct	p.S44P	KLRF1_ENST00000537723.1_Missense_Mutation_p.S44P|KLRF1_ENST00000354855.3_Missense_Mutation_p.S44P|KLRF1_ENST00000324214.4_Missense_Mutation_p.S44P	NM_016523.1	NP_057607.1	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F, member 1	44					cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			breast(1)|endometrium(2)|large_intestine(4)|lung(6)	13						ACTGGGAATATCTGGAACCGT	0.323000													9	28					0	0	0.000443	0	0
CALB2	794	broad.mit.edu	37	16	71406097	71406097	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:71406097C>T	ENST00000302628.4	+	2	213	c.136C>T	c.(136-138)Caa>Taa	p.Q46*	CALB2_ENST00000349553.5_Nonsense_Mutation_p.Q46*	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	46	EF-hand 1.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				AAACTTTTTCCAAGAGCTGGA	0.458000													13	58					0	0	0.003163	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170352	20170352	+	RNA	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:20170352C>T	ENST00000338912.5	-	0	2																											AAGTCCAGCCCATGGTGAGGA	0.532000													29	102					0	0	0.001786	0	0
CASQ1	844	broad.mit.edu	37	1	160160609	160160609	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:160160609T>A	ENST00000368079.3	+	1	325	c.50T>A	c.(49-51)cTg>cAg	p.L17Q	CASQ1_ENST00000368078.3_Missense_Mutation_p.L23Q	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	23	Poly-Leu.					mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGTTGCTGCTGGTGCTAGGG	0.592000													9	38					0	0	0.000673	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762242	130762242	+	Silent	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:130762242C>G	ENST00000392429.1	+	2	3053	c.675C>G	c.(673-675)tcC>tcG	p.S225S	TMEM200A_ENST00000296978.3_Silent_p.S225S|TMEM200A_ENST00000545622.1_Silent_p.S225S	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	225						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TGGACAGCTCCGTGGAGGAGG	0.488000													6	44					0	0	0.001168	0	0
WDR11	55717	broad.mit.edu	37	10	122618278	122618278	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:122618278G>A	ENST00000263461.6	+	3	568	c.322G>A	c.(322-324)Gag>Aag	p.E108K		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	108						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						AGCTCAGTGTGAGATCCAAGA	0.458000													6	41					0	0	0.001168	0	0
LRFN5	145581	broad.mit.edu	37	14	42356976	42356976	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:42356976G>T	ENST00000554171.1	+	5	3580	c.1148G>T	c.(1147-1149)aGt>aTt	p.S383I	LRFN5_ENST00000298119.4_Missense_Mutation_p.S383I|LRFN5_ENST00000554120.1_Missense_Mutation_p.S383I			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	383						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTACTAAATAGTACAAACCAT	0.393000										HNSCC(30;0.082)			10	56					1.58986e-06	3.38288e-06	0.000673	1	0
FUT9	10690	broad.mit.edu	37	6	96651056	96651056	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:96651056C>G	ENST00000302103.5	+	3	351	c.25C>G	c.(25-27)Ctt>Gtt	p.L9V		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	9					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CAAAGGAATTCTTCGCCCATT	0.393000													15	69					0	0	0.004990	0	0
FRMD6	122786	broad.mit.edu	37	14	52194577	52194577	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:52194577C>G	ENST00000395718.2	+	14	1960	c.1675C>G	c.(1675-1677)Cag>Gag	p.Q559E	FRMD6_ENST00000356218.4_Missense_Mutation_p.Q559E|FRMD6_ENST00000553556.1_Missense_Mutation_p.Q209E|FRMD6_ENST00000554167.1_Missense_Mutation_p.Q490E|FRMD6_ENST00000344768.5_Missense_Mutation_p.Q567E	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	567						cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					GGACACTGCTCAGAGTTACAC	0.502000													11	45					0	0	0.000673	0	0
SFSWAP	6433	broad.mit.edu	37	12	132281832	132281832	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:132281832C>G	ENST00000261674.4	+	16	2785	c.2644C>G	c.(2644-2646)Ccc>Gcc	p.P882A	SFSWAP_ENST00000541286.1_Missense_Mutation_p.P934A|SFSWAP_ENST00000539506.1_3'UTR	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	882	Arg/Ser-rich (RS domain).				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						gcccgcggcccccgcggcccA	0.697000													15	60					0	0	0.004007	0	0
DIO3	1735	broad.mit.edu	37	14	102028010	102028010	+	Silent	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:102028010C>G	ENST00000359323.3	+	1	323	c.99C>G	c.(97-99)ctC>ctG	p.L33L	DIO3_ENST00000510508.4_Silent_p.L59L	NM_001362.3	NP_001353.4	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	33					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				CCTTCATGCTCTGGCTTCTCG	0.657000													10	77					0	0	0.000673	0	0
AASDH	132949	broad.mit.edu	37	4	57221514	57221514	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:57221514G>A	ENST00000205214.6	-	6	1117	c.937C>T	c.(937-939)Cga>Tga	p.R313*	AASDH_ENST00000602986.1_Nonsense_Mutation_p.R160*|AASDH_ENST00000502617.1_Nonsense_Mutation_p.R313*|AASDH_ENST00000451613.1_Nonsense_Mutation_p.R313*|AASDH_ENST00000510762.1_5'UTR|AASDH_ENST00000513376.1_Nonsense_Mutation_p.R213*|AASDH_ENST00000434343.2_5'UTR	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	313					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GCTAATACTCGAAGAGAAGTA	0.368000													10	59					0	0	0.001368	0	0
SLC6A5	9152	broad.mit.edu	37	11	20639323	20639323	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:20639323G>T	ENST00000525748.1	+	7	1426	c.1153G>T	c.(1153-1155)Ggg>Tgg	p.G385W		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	385					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity	p.G385W(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	GATTTCTGCAGGGATTGAATA	0.502000													10	89					0.000978159	0.00196659	0.000978	1	0
PCDH11X	27328	broad.mit.edu	37	X	91134302	91134302	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:91134302C>G	ENST00000361724.1	+	2	3908	c.3063C>G	c.(3061-3063)ttC>ttG	p.F1021L	PCDH11X_ENST00000373097.1_Intron|PCDH11X_ENST00000504220.1_Intron|PCDH11X_ENST00000298274.8_Intron|PCDH11X_ENST00000361655.2_Intron|PCDH11X_ENST00000373088.1_Intron|PCDH11X_ENST00000395337.2_Intron|PCDH11X_ENST00000373094.1_Intron|PCDH11X_ENST00000406881.1_Intron	NM_014522.1	NP_055337.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						ACACAACTTTCTAACTATTTT	0.383000													9	44					0	0	0.004482	0	0
USP6	9098	broad.mit.edu	37	17	5036229	5036229	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:5036229A>G	ENST00000574788.1	+	13	2450	c.220A>G	c.(220-222)Acg>Gcg	p.T74A	USP6_ENST00000304328.5_5'UTR|USP6_ENST00000572429.1_3'UTR|USP6_ENST00000332776.4_Missense_Mutation_p.T74A|USP6_ENST00000250066.6_Missense_Mutation_p.T74A			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	74					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GATGACACGAACGAGCAAGTG	0.532000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								3	153					0	0	0.004672	0	0
ZNF85	7639	broad.mit.edu	37	19	21132951	21132951	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:21132951G>A	ENST00000601023.1	+	2	2100	c.1454G>A	c.(1453-1455)gGc>gAc	p.G485D	ZNF85_ENST00000328178.8_Missense_Mutation_p.G544D|ZNF85_ENST00000345030.6_Missense_Mutation_p.G511D			Q03923	ZNF85_HUMAN	zinc finger protein 85	544						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						GAAGAATGTGGCAAAGCCTTT	0.348000													5	41					0	0	0.000602	0	0
TSTA3	7264	broad.mit.edu	37	8	144696589	144696589	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:144696589C>T	ENST00000425753.2	-	6	602	c.499G>A	c.(499-501)Gct>Act	p.A167T	TSTA3_ENST00000529064.1_Missense_Mutation_p.A167T	NM_003313.3	NP_003304.1	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	167					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	GGGATGACAGCGGTGAAGGTG	0.662000													4	38					0	0	0.000602	0	0
KYNU	8942	broad.mit.edu	37	2	143712377	143712377	+	Splice_Site	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:143712377A>G	ENST00000264170.4	+	5	631		c.e5-1		KYNU_ENST00000409512.1_Splice_Site|KYNU_ENST00000375773.2_Splice_Site	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase						anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTATTTTACAGGAGCCAATG	0.303000													11	27					0	0	0.000978	0	0
USH2A	7399	broad.mit.edu	37	1	215821936	215821936	+	Missense_Mutation	SNP	G	G	A	rs139065588		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:215821936G>A	ENST00000366943.2	-	66	14902	c.14516C>T	c.(14515-14517)aCg>aTg	p.T4839M	USH2A_ENST00000307340.3_Missense_Mutation_p.T4839M			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4839	Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.T4839K(1)|p.T4839M(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGAGGCCAGCGTCCCGATTTG	0.572000										HNSCC(13;0.011)			23	65					0	0	0.001882	0	0
TNXB	7148	broad.mit.edu	37	6	32036752	32036752	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:32036752C>G	ENST00000375244.3	-	16	5950	c.5749G>C	c.(5749-5751)Gat>Cat	p.D1917H	TNXB_ENST00000375247.2_Missense_Mutation_p.D1917H			P22105	TENX_HUMAN	tenascin XB	1999	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCGTCTCTATCTGTGTACTGG	0.552000													17	61					0	0	0.000958	0	0
TAAR6	319100	broad.mit.edu	37	6	132891511	132891511	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:132891511C>A	ENST00000275198.1	+	1	51	c.51C>A	c.(49-51)aaC>aaA	p.N17K		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	17						plasma membrane	G-protein coupled receptor activity	p.N17K(1)		cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		GCTACGCGAACGTGAATGGGT	0.493000													18	76					2.35188e-11	5.42633e-11	0.006122	1	0
SDHA	6389	broad.mit.edu	37	5	228381	228381	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:228381A>T	ENST00000264932.6	+	6	818	c.703A>T	c.(703-705)Atc>Ttc	p.I235F	SDHA_ENST00000504309.1_Missense_Mutation_p.I235F|SDHA_ENST00000510361.1_Missense_Mutation_p.I187F	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	235					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCGTGGTGTCATCGCACTGTG	0.428000									Familial Paragangliomas				3	38					0	0	0.000248	0	0
COL25A1	84570	broad.mit.edu	37	4	109769944	109769944	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:109769944G>C	ENST00000399132.1	-	27	1935	c.1405C>G	c.(1405-1407)Cca>Gca	p.P469A	COL25A1_ENST00000399127.1_Missense_Mutation_p.P442A|COL25A1_ENST00000399126.1_Missense_Mutation_p.P469A	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	469	Collagen-like 6.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GGGATTCCTGGAGATCCCTGC	0.348000													9	36					0	0	0.000673	0	0
LNP1	348801	broad.mit.edu	37	3	100170695	100170695	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:100170695C>A	ENST00000383693.3	+	3	1569	c.289C>A	c.(289-291)Cca>Aca	p.P97T	LNP1_ENST00000489752.1_Missense_Mutation_p.P110T	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	97										cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						ATTCAAGGAGCCACTGGAATC	0.453000													15	59					3.45872e-05	7.16048e-05	0.004007	1	0
C16orf58	64755	broad.mit.edu	37	16	31502206	31502206	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:31502206C>T	ENST00000327237.2	-	13	1396	c.1357G>A	c.(1357-1359)Gat>Aat	p.D453N	C16orf58_ENST00000567994.1_Missense_Mutation_p.D408N|C16orf58_ENST00000570164.1_Missense_Mutation_p.D451N			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	453				D -> G (in Ref. 1; BAB14730).		integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						CTCCACTCATCCACCTCTAGC	0.612000													20	71					0	0	0.002299	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130318901	130318901	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:130318901C>T	ENST00000299164.2	+	1	33	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	11					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.F11F(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCCTGGCTTTCGCCGGGCGAA	0.711000													4	29					0	0	0.000602	0	0
NFE2L1	4779	broad.mit.edu	37	17	46135825	46135825	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:46135825G>T	ENST00000362042.3	+	6	1757	c.1141G>T	c.(1141-1143)Gag>Tag	p.E381*	NFE2L1_ENST00000582155.1_Nonsense_Mutation_p.E193*|NFE2L1_ENST00000583378.1_Nonsense_Mutation_p.E182*|NFE2L1_ENST00000585291.1_Nonsense_Mutation_p.E351*|NFE2L1_ENST00000361665.3_Nonsense_Mutation_p.E370*|NFE2L1_ENST00000536222.1_Nonsense_Mutation_p.E225*|NFE2L1_ENST00000357480.5_Nonsense_Mutation_p.E351*	NM_003204.2	NP_003195.1	Q14494	NF2L1_HUMAN	nuclear factor, erythroid 2-like 1	381					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			cervix(1)|endometrium(3)|kidney(9)|large_intestine(7)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTTCAGCCCCGAGGTGGAAAG	0.607000													32	85					9.78306e-22	2.40959e-21	0.001786	1	0
CSNK2A2	1459	broad.mit.edu	37	16	58198043	58198043	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:58198043C>A	ENST00000262506.3	-	11	1168	c.985G>T	c.(985-987)Gtg>Ttg	p.V329L	CSNK2A2_ENST00000566813.1_5'UTR	NM_001896.2	NP_001887.1	P19784	CSK22_HUMAN	casein kinase 2, alpha prime polypeptide	329					axon guidance|Wnt receptor signaling pathway	cytosol|nucleus	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TGCTCCTTCACCACAGGGTCT	0.547000													13	58					1.61879e-10	3.63635e-10	0.001368	1	0
TUBA3C	7278	broad.mit.edu	37	13	19748110	19748110	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:19748110C>A	ENST00000400113.3	-	5	1350	c.1246G>T	c.(1246-1248)Ggg>Tgg	p.G416W		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	416					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAGAACTCCCCCTCCTCCATG	0.602000													31	113					3.86903e-22	9.56024e-22	0.002836	1	0
EPB41L3	23136	broad.mit.edu	37	18	5397146	5397146	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:5397146C>G	ENST00000341928.2	-	18	3092	c.2752G>C	c.(2752-2754)Gag>Cag	p.E918Q	EPB41L3_ENST00000540638.2_Missense_Mutation_p.E696Q|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000427684.2_Missense_Mutation_p.E215Q|EPB41L3_ENST00000544123.1_Missense_Mutation_p.E749Q|EPB41L3_ENST00000542146.1_Missense_Mutation_p.E223Q|EPB41L3_ENST00000342933.3_Missense_Mutation_p.E918Q|EPB41L3_ENST00000400111.3_Missense_Mutation_p.E696Q	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	918	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GCGGCTGTCTCTTCCTGTTCC	0.522000													6	136					0	0	0.001984	0	0
EYA4	2070	broad.mit.edu	37	6	133802716	133802716	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:133802716G>T	ENST00000367895.5	+	12	1550	c.1086G>T	c.(1084-1086)ccG>ccT	p.P362P	EYA4_ENST00000355167.3_Silent_p.P362P|EYA4_ENST00000355286.6_Silent_p.P339P|EYA4_ENST00000430974.2_Silent_p.P314P|EYA4_ENST00000452339.2_Silent_p.P308P|EYA4_ENST00000531901.1_Silent_p.P368P|EYA4_ENST00000431403.2_Silent_p.P362P|EYA4_ENST00000525849.1_Silent_p.P339P	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	362					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		ATCCCTCCCCGCCTCCTGATA	0.448000													23	82					7.41877e-09	1.63298e-08	0.001882	1	0
OR4C15	81309	broad.mit.edu	37	11	55322833	55322833	+	Missense_Mutation	SNP	A	A	T	rs112163324		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:55322833A>T	ENST00000314644.2	+	1	1051	c.1051A>T	c.(1051-1053)Atg>Ttg	p.M351L		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						AAAACAGGCCATGAGGAGAAT	0.333000										HNSCC(20;0.049)			9	55					0	0	0.004482	0	0
CTNNA2	1496	broad.mit.edu	37	2	80097016	80097016	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:80097016G>T	ENST00000466387.1	+	9	1264	c.540G>T	c.(538-540)ggG>ggT	p.G180G	CTNNA2_ENST00000496558.1_Silent_p.G180G|CTNNA2_ENST00000541047.1_Silent_p.G180G|CTNNA2_ENST00000540488.1_Silent_p.G180G|CTNNA2_ENST00000361291.4_Silent_p.G214G|CTNNA2_ENST00000402739.4_Silent_p.G180G			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	180					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAGAGTTTGGGAAAGAGATGG	0.403000													8	52					5.4927e-09	1.21601e-08	0.004482	1	0
FCRL3	115352	broad.mit.edu	37	1	157667698	157667698	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:157667698G>T	ENST00000368184.3	-	5	601	c.310C>A	c.(310-312)Ctg>Atg	p.L104M	FCRL3_ENST00000368186.5_Missense_Mutation_p.L104M|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	104	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AAAGCCTGCAGGATCAGCCAG	0.468000													7	27					8.12818e-05	0.00016559	0.001984	1	0
ZNF536	9745	broad.mit.edu	37	19	31039948	31039948	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:31039948C>G	ENST00000355537.3	+	4	3569	c.3422C>G	c.(3421-3423)tCt>tGt	p.S1141C		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AAGGCCCACTCTGAAGAGGAT	0.542000													6	38					0	0	0.001984	0	0
AMOT	154796	broad.mit.edu	37	X	112033890	112033890	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:112033890G>C	ENST00000371959.3	-	7	2046	c.2047C>G	c.(2047-2049)Cag>Gag	p.Q683E	AMOT_ENST00000371962.1_Missense_Mutation_p.Q451E|AMOT_ENST00000371958.1_Missense_Mutation_p.Q451E|AMOT_ENST00000304758.1_Missense_Mutation_p.Q274E|AMOT_ENST00000524145.1_Missense_Mutation_p.Q683E	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	683					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						AAATATTTCTGCTCCCACTTT	0.493000													39	168					0	0	0.004289	0	0
TTC14	151613	broad.mit.edu	37	3	180324283	180324283	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:180324283G>T	ENST00000412756.2	+	9	1133	c.1064G>T	c.(1063-1065)gGa>gTa	p.G355V	TTC14_ENST00000382584.4_Missense_Mutation_p.G355V|TTC14_ENST00000296015.4_Missense_Mutation_p.G355V	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	355							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GCGACAAAAGGAAGTTTGAAC	0.373000													11	135					5.50884e-06	1.15928e-05	0.001368	1	0
OR4C15	81309	broad.mit.edu	37	11	55322242	55322242	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:55322242C>A	ENST00000314644.2	+	1	460	c.460C>A	c.(460-462)Ctc>Atc	p.L154I		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CATGATGCAGCTCTTTGCTGA	0.478000										HNSCC(20;0.049)			29	110					1.2476e-16	3.02424e-16	0.001061	1	0
NTRK1	4914	broad.mit.edu	37	1	156849868	156849868	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:156849868C>T	ENST00000368196.3	+	15	2226	c.2106C>T	c.(2104-2106)agC>agT	p.S702S	NTRK1_ENST00000392302.2_Silent_p.S672S|NTRK1_ENST00000524377.1_Silent_p.S708S|NTRK1_ENST00000358660.3_Silent_p.S705S|NTRK1_ENST00000531606.1_3'UTR	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	708	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCACCGAGAGCGACGTGTGGA	0.647000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			5	82					0	0	0.000602	0	0
PRKD1	5587	broad.mit.edu	37	14	30066700	30066700	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:30066700C>G	ENST00000331968.5	-	16	2660	c.2431G>C	c.(2431-2433)Gaa>Caa	p.E811Q	PRKD1_ENST00000415220.2_Missense_Mutation_p.E819Q	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	811	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		ATATTACCTTCATGAGATATT	0.279000													12	66					0	0	0.001855	0	0
EEA1	8411	broad.mit.edu	37	12	93219970	93219970	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:93219970C>A	ENST00000322349.8	-	13	1760	c.1496G>T	c.(1495-1497)aGc>aTc	p.S499I		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	499	Gln/Glu/Lys-rich.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						TGCCGTGGTGCTTTGCTGAAG	0.328000													5	27					0.00116845	0.00233689	0.001168	1	0
DEPDC5	9681	broad.mit.edu	37	22	32217595	32217595	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:32217595G>A	ENST00000400246.1	+	23	2120	c.1978G>A	c.(1978-1980)Gag>Aag	p.E660K	DEPDC5_ENST00000400248.1_Missense_Mutation_p.E660K|DEPDC5_ENST00000400249.2_Missense_Mutation_p.E660K|DEPDC5_ENST00000382111.2_Missense_Mutation_p.E660K|DEPDC5_ENST00000382112.3_Missense_Mutation_p.E660K|DEPDC5_ENST00000382105.2_Intron|DEPDC5_ENST00000266091.3_Missense_Mutation_p.E660K|DEPDC5_ENST00000535622.1_Intron|DEPDC5_ENST00000536766.1_Intron			O75140	DEPD5_HUMAN	DEP domain containing 5	660					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AGAGCTGCTGGAGTTAGCATA	0.557000													24	217					0	0	0.004656	0	0
FAM222A	84915	broad.mit.edu	37	12	110205834	110205834	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:110205834G>T	ENST00000538780.1	+	3	816	c.100G>T	c.(100-102)Gcc>Tcc	p.A34S	FAM222A-AS1_ENST00000541723.1_RNA|FAM222A-AS1_ENST00000541460.1_RNA|FAM222A_ENST00000358906.3_Missense_Mutation_p.A34S	NM_032829.2	NP_116218.2	Q5U5X8	CL034_HUMAN	family with sequence similarity 222, member A	34																	GGTGGCCAGCGCCATGCATTC	0.652000													7	52					0.00307968	0.00601794	0.003080	1	0
CLEC4E	26253	broad.mit.edu	37	12	8691819	8691819	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:8691819C>A	ENST00000299663.3	-	3	379	c.214G>T	c.(214-216)Gga>Tga	p.G72*	CLEC4E_ENST00000446457.2_Nonsense_Mutation_p.G72*|CLEC4E_ENST00000545274.1_Nonsense_Mutation_p.G72*	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	72						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					ATACCTGATCCATAATTGTAG	0.383000													16	108					2.23348e-06	4.73919e-06	0.004007	1	0
SIT1	27240	broad.mit.edu	37	9	35650548	35650548	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:35650548A>T	ENST00000259608.3	-	2	273	c.187T>A	c.(187-189)Ttg>Atg	p.L63M	SIT1_ENST00000474403.1_Intron	NM_014450.2	NP_055265.1	Q9Y3P8	SIT1_HUMAN	signaling threshold regulating transmembrane adaptor 1	63					regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding			endometrium(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	9			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CACTGGGACAAGTGTGCAGCC	0.597000													58	69					0	0	0.003610	0	0
HARBI1	283254	broad.mit.edu	37	11	46637351	46637351	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:46637351C>G	ENST00000326737.3	-	2	684	c.437G>C	c.(436-438)gGg>gCg	p.G146A		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	146						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						GTCAACCACCCCCATCACCCC	0.512000													46	195					0	0	0.003610	0	0
FZR1	51343	broad.mit.edu	37	19	3527705	3527705	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:3527705G>A	ENST00000441788.2	+	7	783	c.547G>A	c.(547-549)Gag>Aag	p.E183K	FZR1_ENST00000313639.8_Intron|FZR1_ENST00000395095.3_Missense_Mutation_p.E183K	NM_016263.3	NP_057347.2	Q9UM11	FZR_HUMAN	fizzy/cell division cycle 20 related 1 (Drosophila)	183					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			endometrium(1)|kidney(4)|liver(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACGCGCCCGAGCTGCAGGA	0.632000													6	42					0	0	0.001168	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780146	91780146	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:91780146G>A	ENST00000389857.6	-	15	2100	c.2014C>T	c.(2014-2016)Cag>Tag	p.Q672*		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	672					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TTCTCCAGCTGCAGGCCCTGG	0.627000													6	15					0	0	0.001984	0	0
MOCOS	55034	broad.mit.edu	37	18	33828964	33828964	+	Splice_Site	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:33828964G>T	ENST00000261326.5	+	10	2060		c.e10+1			NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase						Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	GTGCTGACAGGTGAGACTCTG	0.473000													7	21					8.12818e-05	0.00016559	0.001984	1	0
FAM69C	125704	broad.mit.edu	37	18	72103843	72103843	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:72103843G>C	ENST00000343998.6	-	4	1161	c.1153C>G	c.(1153-1155)Cct>Gct	p.P385A	FAM69C_ENST00000400291.2_Missense_Mutation_p.P86A	NM_001044369.2	NP_001037834.2	Q0P6D2	FA69C_HUMAN	family with sequence similarity 69, member C	385						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(2)|ovary(2)	5						GGGACCCCAGGGTCTGCACAT	0.587000													6	21					0	0	0.001168	0	0
KRTAP20-1	337975	broad.mit.edu	37	21	31988891	31988891	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr21:31988891G>T	ENST00000334664.2	+	1	142	c.118G>T	c.(118-120)Ggc>Tgc	p.G40C		NM_181615.1	NP_853646.1	Q3LI63	KR201_HUMAN	keratin associated protein 20-1	40						intermediate filament				breast(1)|endometrium(3)|lung(1)|pancreas(1)|skin(1)	7						CTATGGAAATGGCTACTACTG	0.463000													11	42					1.08611e-07	2.35682e-07	0.000978	1	0
NPAS3	64067	broad.mit.edu	37	14	33684490	33684490	+	Silent	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:33684490T>A	ENST00000346562.2	+	2	227	c.153T>A	c.(151-153)ccT>ccA	p.P51P	NPAS3_ENST00000356141.4_Silent_p.P81P|NPAS3_ENST00000341321.4_Silent_p.P81P|NPAS3_ENST00000547068.1_5'UTR|NPAS3_ENST00000551492.1_Silent_p.P88P|NPAS3_ENST00000548645.1_Silent_p.P51P|NPAS3_ENST00000551008.1_5'UTR|NPAS3_ENST00000357798.5_Silent_p.P51P	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TGCCTCTTCCTGCAGCCATTA	0.493000													17	103					0	0	0.000958	0	0
TMEM241	85019	broad.mit.edu	37	18	20979546	20979546	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:20979546C>G	ENST00000383233.3	-	4	315	c.263G>C	c.(262-264)aGa>aCa	p.R88T	TMEM241_ENST00000542162.1_Missense_Mutation_p.R88T|TMEM241_ENST00000450466.2_Intron|TMEM241_ENST00000399707.1_Missense_Mutation_p.R62T	NM_032933.4	NP_116322.3	Q24JQ0	CR045_HUMAN	transmembrane protein 241	88						integral to membrane											GGACAATGCTCTGGACCCAGC	0.443000													8	69					0	0	0.000443	0	0
TNN	63923	broad.mit.edu	37	1	175086104	175086104	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:175086104G>T	ENST00000239462.4	+	10	2262	c.2149G>T	c.(2149-2151)Gac>Tac	p.D717Y		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	717	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix		p.D717N(1)		NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCTGGTGACCGACCGGGTGAC	0.512000													25	119					2.44723e-14	5.83981e-14	0.004656	1	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216847	26216847	+	Missense_Mutation	SNP	G	G	C	rs149681157		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:26216847G>C	ENST00000244601.3	-	1	25	c.25C>G	c.(25-27)Cct>Gct	p.P9A		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	9					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				TTCGGAGCAGGAGCTGACTTA	0.483000													11	67					0	0	0.003163	0	0
KIAA0825	285600	broad.mit.edu	37	5	93856022	93856022	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:93856022C>G	ENST00000513200.3	-	4	973	c.901G>C	c.(901-903)Gaa>Caa	p.E301Q	KIAA0825_ENST00000427991.2_Missense_Mutation_p.E301Q|KIAA0825_ENST00000312498.7_Missense_Mutation_p.E301Q|KIAA0825_ENST00000329378.7_Missense_Mutation_p.E301Q	NM_001145678.1	NP_001139150.1	Q8IV33	K0825_HUMAN	KIAA0825	301										breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(1)	13						ACAGCATTTTCTCTGAACTGC	0.363000													9	18					0	0	0.004482	0	0
TRPM3	80036	broad.mit.edu	37	9	73167807	73167807	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:73167807C>T	ENST00000377110.2	-	23	3734	c.3491G>A	c.(3490-3492)cGa>cAa	p.R1164Q	TRPM3_ENST00000396285.1_Missense_Mutation_p.R1023Q|TRPM3_ENST00000360823.2_Missense_Mutation_p.R1026Q|TRPM3_ENST00000396280.5_Missense_Mutation_p.R1013Q|TRPM3_ENST00000396292.4_Missense_Mutation_p.R1036Q|TRPM3_ENST00000357533.2_Missense_Mutation_p.R1168Q|TRPM3_ENST00000423814.3_Missense_Mutation_p.R1191Q|TRPM3_ENST00000377105.1_Missense_Mutation_p.R1023Q|TRPM3_ENST00000377106.1_Missense_Mutation_p.R1036Q|TRPM3_ENST00000408909.2_Missense_Mutation_p.R1023Q|TRPM3_ENST00000377111.2_Missense_Mutation_p.R1164Q|TRPM3_ENST00000358082.3_Missense_Mutation_p.R1026Q	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1189						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TTTCCTCCATCGGCAGCACAG	0.527000													24	222					0	0	0.003330	0	0
XIST	7503	broad.mit.edu	37	X	73067568	73067568	+	RNA	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:73067568T>C	ENST00000429829.1	-	0	5020					NR_001564.2																						GAGTCATGGATAATTAGAAAT	0.328000													13	25					0	0	0.001368	0	0
FRRS1L	23732	broad.mit.edu	37	9	111903626	111903626	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:111903626G>A	ENST00000374581.3	-	4	858	c.859C>T	c.(859-861)Cag>Tag	p.Q287*		NM_014334.2	NP_055149.2	Q9P0K9	CI004_HUMAN	ferric-chelate reductase 1-like	287						integral to membrane											AGCTTACCCTGAATGGCTGGA	0.433000													5	34					0	0	0.001168	0	0
PAPOLA	10914	broad.mit.edu	37	14	97022574	97022574	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:97022574C>T	ENST00000216277.8	+	19	2048	c.1828C>T	c.(1828-1830)Cct>Tct	p.P610S	PAPOLA_ENST00000392990.2_Missense_Mutation_p.P610S	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	610	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACCACCAAAGCCTACGGTCTC	0.418000													22	86					0	0	0.001882	0	0
CRB1	23418	broad.mit.edu	37	1	197403914	197403914	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:197403914C>A	ENST00000367397.1	+	5	1922	c.1064C>A	c.(1063-1065)aCc>aAc	p.T355N	CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.T455N|CRB1_ENST00000367400.3_Missense_Mutation_p.T974N|CRB1_ENST00000535699.1_Missense_Mutation_p.T950N|CRB1_ENST00000367399.2_Missense_Mutation_p.T862N			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	974	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.T974S(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGAGAACTCACCAATATCACA	0.333000													8	42					0.00307968	0.00601794	0.003080	1	0
ZSWIM5	57643	broad.mit.edu	37	1	45516821	45516821	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:45516821G>C	ENST00000359600.5	-	5	1562	c.1357C>G	c.(1357-1359)Ctg>Gtg	p.L453V		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	453							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					CCATCCTCCAGGGGACAGACA	0.517000													35	56					0	0	0.003755	0	0
OR6K6	128371	broad.mit.edu	37	1	158724934	158724934	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:158724934T>G	ENST00000368144.2	+	1	425	c.329T>G	c.(328-330)cTg>cGg	p.L110R		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					CCCAAGATGCTGTCCTGCCTA	0.512000													35	113					0	0	0.005524	0	0
RELN	5649	broad.mit.edu	37	7	103237037	103237037	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:103237037C>A	ENST00000424685.2	-	25	3564	c.3405G>T	c.(3403-3405)caG>caT	p.Q1135H	RELN_ENST00000343529.5_Missense_Mutation_p.Q1135H|RELN_ENST00000428762.1_Missense_Mutation_p.Q1135H			P78509	RELN_HUMAN	reelin	1135					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTCCGCCTATCTGGATGTAGA	0.502000													24	102					4.72057e-08	1.03019e-07	0.003954	1	0
OR8K3	219473	broad.mit.edu	37	11	56086330	56086330	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:56086330C>A	ENST00000312711.1	+	1	548	c.548C>A	c.(547-549)cCt>cAt	p.P183H		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					GACAGTCTCCCTTTGTTACCT	0.328000													18	77					5.35267e-07	1.14529e-06	0.000958	1	0
NOX5	79400	broad.mit.edu	37	15	69335123	69335123	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:69335123G>C	ENST00000260364.5	+	11	1872	c.1571G>C	c.(1570-1572)aGa>aCa	p.R524T	NOX5_ENST00000388866.3_Missense_Mutation_p.R542T|NOX5_ENST00000448182.3_Missense_Mutation_p.R496T|NOX5_ENST00000530406.2_Missense_Mutation_p.R514T|NOX5_ENST00000455873.3_Missense_Mutation_p.R507T|RP11-809H16.4_ENST00000559495.1_RNA			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	542	C-terminal catalytic region.|FAD-binding FR-type.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						GTGACAATGAGAAAGAGTCAA	0.552000													19	17					0	0	0.000958	0	0
TTBK2	146057	broad.mit.edu	37	15	43067454	43067454	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:43067454G>A	ENST00000267890.6	-	13	1985	c.1877C>T	c.(1876-1878)cCt>cTt	p.P626L		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	626					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGCAGCAGTAGGAGGACCCTC	0.488000													63	67					0	0	0.003610	0	0
ETV6	2120	broad.mit.edu	37	12	12022820	12022820	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:12022820G>T	ENST00000396373.4	+	5	1200	c.926G>T	c.(925-927)cGg>cTg	p.R309L		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	309						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTCTCTCATCGGGAAGACCTG	0.577000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								23	98					1.55469e-16	3.75677e-16	0.003330	1	0
CFHR2	3080	broad.mit.edu	37	1	196920114	196920114	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:196920114G>T	ENST00000367415.4	+	3	500	c.386G>T	c.(385-387)tGt>tTt	p.C129F	CFHR2_ENST00000367421.3_Missense_Mutation_p.C129F|CFHR2_ENST00000476712.1_3'UTR	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	129	Sushi 2.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						AACATTTCATGTGTAGAACGG	0.383000													7	51					0.00448238	0.00873665	0.004482	1	0
WDR64	128025	broad.mit.edu	37	1	241953918	241953918	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:241953918C>G	ENST00000366552.2	+	24	3094	c.2887C>G	c.(2887-2889)Cta>Gta	p.L963V	WDR64_ENST00000437684.2_Missense_Mutation_p.L796V	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	963										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CTCAGTGTCTCTACTTTTCAA	0.353000													26	84					0	0	0.001061	0	0
LILRB5	10990	broad.mit.edu	37	19	54756392	54756392	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:54756392C>T	ENST00000450632.1	-	10	1545	c.1468G>A	c.(1468-1470)Ggg>Agg	p.G490R	LILRB5_ENST00000345866.6_Missense_Mutation_p.G399R|LILRB5_ENST00000449561.2_Missense_Mutation_p.G499R|LILRB5_ENST00000316219.5_Missense_Mutation_p.G498R			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	498					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCCGCAGCCCCTGCAGGACGG	0.607000													8	76					0	0	0.003080	0	0
NTN1	9423	broad.mit.edu	37	17	9143248	9143248	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:9143248A>G	ENST00000173229.2	+	7	1885	c.1778A>G	c.(1777-1779)cAg>cGg	p.Q593R	NTN1_ENST00000538852.1_Missense_Mutation_p.Q593R|NTN1_ENST00000546090.1_Missense_Mutation_p.Q593R	NM_004822.2	NP_004813.2	O95631	NET1_HUMAN	netrin 1	593	NTR.				apoptosis|axon guidance		protein binding		NTN1/ACLY(2)	central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(5)	13						CGCAAGTTCCAGCAGCGTGAG	0.721000													3	13					0	0	0.004672	0	0
C12orf40	283461	broad.mit.edu	37	12	40076630	40076630	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:40076630C>A	ENST00000324616.5	+	8	1058	c.904C>A	c.(904-906)Caa>Aaa	p.Q302K	C12orf40_ENST00000405531.3_Missense_Mutation_p.Q302K|C12orf40_ENST00000398716.1_Missense_Mutation_p.Q225K	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	302										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						TTTTGTTAGTCAAAATATGAT	0.323000													18	53					1.99824e-07	4.31169e-07	0.004990	1	0
WSCD2	9671	broad.mit.edu	37	12	108589738	108589738	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:108589738C>T	ENST00000332082.4	+	3	947	c.129C>T	c.(127-129)ccC>ccT	p.P43P	WSCD2_ENST00000547525.1_Silent_p.P43P|WSCD2_ENST00000261400.3_Silent_p.P43P|WSCD2_ENST00000549903.1_Silent_p.P43P			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	43						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						TGGGCCAGCCCGCTGTCTCGG	0.612000													30	135					0	0	0.001061	0	0
BPIFB6	128859	broad.mit.edu	37	20	31620830	31620830	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:31620830G>A	ENST00000349552.1	+	2	138	c.138G>A	c.(136-138)aaG>aaA	p.K46K		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	46						extracellular region	lipid binding										TCCTGGAGAAGATGGCAGCCG	0.557000													16	87					0	0	0.001216	0	0
AGAP5	729092	broad.mit.edu	37	10	75457410	75457410	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:75457410C>T	ENST00000443782.2	-	1	229	c.104G>A	c.(103-105)gGa>gAa	p.G35E	RP11-464F9.1_ENST00000399449.3_RNA|AGAP5_ENST00000374094.4_Missense_Mutation_p.G35E			A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	35					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(5)|skin(1)	12						GTCCCCAGCTCCTGCCTCATA	0.582000													21	152					0	0	0.002299	0	0
PROX1	5629	broad.mit.edu	37	1	214170122	214170122	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:214170122G>C	ENST00000366958.4	+	2	852	c.244G>C	c.(244-246)Gat>Cat	p.D82H	PROX1_ENST00000435016.1_Missense_Mutation_p.D82H|PROX1_ENST00000261454.4_Missense_Mutation_p.D82H|PROX1_ENST00000498508.2_Missense_Mutation_p.D82H	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	82					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTCGTATGAAGATGCCATGAT	0.483000													4	83					0	0	0.000248	0	0
SLC7A3	84889	broad.mit.edu	37	X	70146774	70146774	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:70146774G>A	ENST00000374299.3	-	9	1548	c.1404C>T	c.(1402-1404)atC>atT	p.I468I	SLC7A3_ENST00000298085.4_Silent_p.I468I			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	468					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GTGGAGTGGGGATGGAGTTGA	0.483000													6	51					0	0	0.001984	0	0
SSTR1	6751	broad.mit.edu	37	14	38679680	38679680	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:38679680C>A	ENST00000267377.2	+	3	1703	c.1086C>A	c.(1084-1086)gcC>gcA	p.A362A		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	362					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	AGAGCCGTGCCTACAGTGTGG	0.612000													18	75					3.51602e-12	8.26156e-12	0.001216	1	0
STT3A	3703	broad.mit.edu	37	11	125484217	125484217	+	Splice_Site	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:125484217A>G	ENST00000392708.4	+	15	1830		c.e15-1		STT3A_ENST00000529196.1_Splice_Site|STT3A_ENST00000531491.1_Splice_Site	NM_001278503.1|NM_001278504.1|NM_152713.3	NP_001265432.1|NP_001265433.1|NP_689926.1	P46977	STT3A_HUMAN	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)						post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			NS(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	33	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		TTGTTTTTCCAGGCAATGGCG	0.453000													19	222					0	0	0.001216	0	0
TEP1	7011	broad.mit.edu	37	14	20849805	20849805	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:20849805G>A	ENST00000262715.5	-	31	4505	c.4465C>T	c.(4465-4467)Ctg>Ttg	p.L1489L	TEP1_ENST00000556935.1_Silent_p.L1381L|TEP1_ENST00000545983.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1489	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGGAGGCACAGCCGGGCACCA	0.602000													17	92					0	0	0.006122	0	0
SYNE1	23345	broad.mit.edu	37	6	152554980	152554980	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:152554980C>T	ENST00000367255.5	-	112	21249	c.20648G>A	c.(20647-20649)cGc>cAc	p.R6883H	SYNE1_ENST00000341594.5_Missense_Mutation_p.R6495H|SYNE1_ENST00000423061.1_Missense_Mutation_p.R6812H|SYNE1_ENST00000356820.4_Missense_Mutation_p.R1407H|SYNE1_ENST00000448038.1_Missense_Mutation_p.R6812H|SYNE1_ENST00000265368.4_Missense_Mutation_p.R6883H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6883					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTATCAATGCGCGACAGCTC	0.512000										HNSCC(10;0.0054)			10	39					0	0	0.000673	0	0
FLG	2312	broad.mit.edu	37	1	152279054	152279054	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:152279054C>T	ENST00000368799.1	-	3	8343	c.8308G>A	c.(8308-8310)Gca>Aca	p.A2770T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2770	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCTTGTGCCTGCTCATGG	0.587000									Ichthyosis				25	833					0	0	0.003330	0	0
BCAN	63827	broad.mit.edu	37	1	156621474	156621474	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:156621474G>A	ENST00000329117.4	+	7	1626	c.1290G>A	c.(1288-1290)acG>acA	p.T430T	BCAN_ENST00000361588.5_Silent_p.T430T|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	430	Glu-rich.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCCCTAGGACGCTCCTAGGTA	0.557000													16	80					0	0	0.003163	0	0
ZNF45	7596	broad.mit.edu	37	19	44417888	44417888	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:44417888C>A	ENST00000269973.5	-	10	2790	c.1700G>T	c.(1699-1701)cGg>cTg	p.R567L	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Missense_Mutation_p.R567L	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	567					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						ATTGGAGGCCCGACAGAAGCC	0.517000													17	85					3.41278e-10	7.59939e-10	0.004990	1	0
DZANK1	55184	broad.mit.edu	37	20	18393348	18393348	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:18393348C>G	ENST00000357236.4	-	14	1691	c.1032G>C	c.(1030-1032)caG>caC	p.Q344H	DZANK1_ENST00000262547.5_Missense_Mutation_p.Q458H|DZANK1_ENST00000377630.5_Missense_Mutation_p.Q291H|DZANK1_ENST00000329494.5_Missense_Mutation_p.Q460H|DZANK1_ENST00000487128.1_5'UTR			Q9NVP4	CT012_HUMAN	double zinc ribbon and ankyrin repeat domains 1	285						intracellular	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(10)	19						TCTCCTGCCTCTGCTTTTGAG	0.517000													19	174					0	0	0.003330	0	0
BIRC6	57448	broad.mit.edu	37	2	32667279	32667279	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:32667279C>T	ENST00000421745.2	+	18	4225	c.4091C>T	c.(4090-4092)tCa>tTa	p.S1364L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1364					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GGAGTTCATTCAAATGGACCC	0.388000													6	43					0	0	0.001168	0	0
FAM135B	51059	broad.mit.edu	37	8	139165260	139165260	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:139165260C>T	ENST00000395297.1	-	13	1628	c.1458G>A	c.(1456-1458)gtG>gtA	p.V486V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	486										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTGTGTGGCCACATTCTCAC	0.393000										HNSCC(54;0.14)			10	78					0	0	0.001368	0	0
OGFR	11054	broad.mit.edu	37	20	61444725	61444725	+	Silent	SNP	G	G	A	rs74520364		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:61444725G>A	ENST00000370461.1	+	5	3879	c.1602G>A	c.(1600-1602)ccG>ccA	p.P534P	OGFR_ENST00000370468.3_Intron|OGFR_ENST00000290291.6_Silent_p.P586P			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	586	7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					GCCCCAGCCCGGCAGGACCTA	0.741000													3	7					0	0	0.004672	0	0
TRIM45	80263	broad.mit.edu	37	1	117656090	117656090	+	Silent	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:117656090C>G	ENST00000256649.4	-	5	2011	c.1485G>C	c.(1483-1485)gtG>gtC	p.V495V	TRIM45_ENST00000369461.3_Silent_p.V438V|TRIM45_ENST00000369464.3_Silent_p.V477V	NM_025188.3	NP_079464.2	Q9H8W5	TRI45_HUMAN	tripartite motif containing 45	495						cytoplasm|nucleus	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|prostate(1)	23	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		TCCTCACCATCACAGTGAATG	0.552000													8	14					0	0	0.003080	0	0
HYAL4	23553	broad.mit.edu	37	7	123516942	123516942	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:123516942C>T	ENST00000223026.4	+	5	1817	c.1179C>T	c.(1177-1179)aaC>aaT	p.N393N	HYAL4_ENST00000476325.1_Silent_p.N393N	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	393					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						AGATGTGGAACGCGCCCAGTT	0.507000													10	60					0	0	0.000443	0	0
MSH3	4437	broad.mit.edu	37	5	79966002	79966002	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:79966002C>G	ENST00000265081.6	+	4	746	c.666C>G	c.(664-666)aaC>aaG	p.N222K		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	222	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		AATCAGCTAACAAACGGTCCA	0.378000								Mismatch excision repair (MMR)					8	22					0	0	0.003080	0	0
POU1F1	5449	broad.mit.edu	37	3	87325510	87325510	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:87325510G>A	ENST00000350375.2	-	1	227	c.103C>T	c.(103-105)Cta>Tta	p.L35L	POU1F1_ENST00000560656.1_Silent_p.L35L|POU1F1_ENST00000344265.3_Silent_p.L35L	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	35					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GAGACTGGTAGACACTCGGCA	0.453000													14	64					0	0	0.003163	0	0
PCDH10	57575	broad.mit.edu	37	4	134084409	134084409	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:134084409G>T	ENST00000264360.4	+	4	3901	c.3075G>T	c.(3073-3075)acG>acT	p.T1025T		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	1025					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		TGACTAATACGCGAGCGCCTT	0.483000													14	134					6.72482e-11	1.53768e-10	0.003163	1	0
FBXL13	222235	broad.mit.edu	37	7	102665637	102665637	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:102665637C>A	ENST00000393772.2	-	6	794	c.368G>T	c.(367-369)aGg>aTg	p.R123M	FBXL13_ENST00000436908.1_Missense_Mutation_p.R123M|FBXL13_ENST00000456695.1_Missense_Mutation_p.R123M|FBXL13_ENST00000379306.3_Missense_Mutation_p.R123M|FBXL13_ENST00000379305.3_Missense_Mutation_p.R123M|FBXL13_ENST00000455112.2_Missense_Mutation_p.R123M|FBXL13_ENST00000471074.1_5'UTR|FBXL13_ENST00000379308.3_Missense_Mutation_p.R123M|FBXL13_ENST00000313221.4_Missense_Mutation_p.R123M			Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13	123										NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|skin(3)|stomach(1)	27						GAGTATTAACCTATTTTTCCA	0.318000													8	19					0.000442599	0.000894541	0.000443	1	0
FSCB	84075	broad.mit.edu	37	14	44975712	44975712	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:44975712C>A	ENST00000340446.4	-	1	770	c.479G>T	c.(478-480)aGt>aTt	p.S160I		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	160						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		TTCTGATTCACTAAAGTATGT	0.418000													29	157					1.13719e-10	2.56958e-10	0.001512	1	0
GRIN2B	2904	broad.mit.edu	37	12	14018815	14018815	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:14018815G>T	ENST00000279593.3	-	2	537	c.328C>A	c.(328-330)Cag>Aag	p.Q110K		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	110					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCGAGGATCTGGGCGATGGCT	0.542000													23	86					5.26018e-13	1.24361e-12	0.001882	1	0
IGSF22	283284	broad.mit.edu	37	11	18741305	18741305	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:18741305C>A	ENST00000513874.1	-	7	793	c.654G>T	c.(652-654)ctG>ctT	p.L218L	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	218	Lys-rich.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						GCTTCCTGAGCAGCCCCCGAA	0.517000													19	158					1.01871e-10	2.30868e-10	0.001216	1	0
FLT3	2322	broad.mit.edu	37	13	28589793	28589793	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:28589793C>A	ENST00000380982.4	-	21	2677	c.2596G>T	c.(2596-2598)Ggc>Tgc	p.G866C	FLT3_ENST00000537084.1_Missense_Mutation_p.G822C|FLT3_ENST00000241453.7_Missense_Mutation_p.G863C			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	863	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTGTAGATGCCTTCAAACAGG	0.483000			"""Mis, O"""		"""AML, ALL"""								18	50					1.01871e-10	2.30868e-10	0.001216	1	0
CAMK2D	817	broad.mit.edu	37	4	114376956	114376956	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:114376956C>T	ENST00000454265.2	-	20	2388	c.1530G>A	c.(1528-1530)ggG>ggA	p.G510G	CAMK2D_ENST00000515496.1_Silent_p.G496G|CAMK2D_ENST00000514328.1_Silent_p.G484G|CAMK2D_ENST00000296402.5_Intron|CAMK2D_ENST00000394524.3_Intron|CAMK2D_ENST00000418639.2_Silent_p.G499G|CAMK2D_ENST00000511664.1_Silent_p.G519G|CAMK2D_ENST00000394526.2_Silent_p.G496G|CAMK2D_ENST00000429180.1_Silent_p.G505G|CAMK2D_ENST00000342666.5_Silent_p.G485G			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	485					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		AGTTTTCTTTCCCATTTGGAA	0.423000													6	36					0	0	0.001168	0	0
COL14A1	7373	broad.mit.edu	37	8	121296005	121296005	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:121296005G>T	ENST00000297848.3	+	32	4225	c.3955G>T	c.(3955-3957)Gtt>Ttt	p.V1319F	COL14A1_ENST00000247781.3_Missense_Mutation_p.V1224F|COL14A1_ENST00000309791.4_Missense_Mutation_p.V1319F	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1319	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ATTGGTTGGGGTTATTTTAGA	0.358000													13	52					0.00136819	0.00272217	0.001368	1	0
BTN2A3P	54718	broad.mit.edu	37	6	26431134	26431134	+	RNA	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:26431134C>G	ENST00000466808.2	+	0	1447																											AGCTTCGCCTCAGGGAAACAT	0.507000													9	96					0	0	0.004482	0	0
WAPAL	23063	broad.mit.edu	37	10	88232004	88232004	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:88232004C>G	ENST00000298767.5	-	7	2463	c.1991G>C	c.(1990-1992)gGc>gCc	p.G664A		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	664	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						GCTCTTTAAGCCACTTAACAA	0.343000													4	41					0	0	0.000248	0	0
SPATA7	55812	broad.mit.edu	37	14	88904701	88904701	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:88904701G>C	ENST00000556553.1	+	12	2198	c.1639G>C	c.(1639-1641)Gac>Cac	p.D547H	SPATA7_ENST00000356583.5_Missense_Mutation_p.D547H|SPATA7_ENST00000045347.7_Missense_Mutation_p.D438H|SPATA7_ENST00000393545.4_Missense_Mutation_p.D579H			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	579					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						CAATAATCATGACATGGAGTT	0.383000													7	28					0	0	0.004482	0	0
F5	2153	broad.mit.edu	37	1	169511664	169511664	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:169511664A>T	ENST00000367796.3	-	13	2880	c.2679T>A	c.(2677-2679)caT>caA	p.H893Q	F5_ENST00000367797.3_Missense_Mutation_p.H888Q			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	888	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCCCAACTTTATGTGCTAGTA	0.473000													32	134					0	0	0.001786	0	0
RSPH3	83861	broad.mit.edu	37	6	159420840	159420840	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:159420840C>G	ENST00000252655.1	-	1	358	c.169G>C	c.(169-171)Gac>Cac	p.D57H	RP1-111C20.4_ENST00000607391.1_RNA|RSPH3_ENST00000297262.3_Missense_Mutation_p.D57H|RSPH3_ENST00000367069.2_5'UTR	NM_031924.4	NP_114130.3	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog (Chlamydomonas)	57										endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|skin(1)|stomach(7)	23		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		AGGGTTCTGTCTGGGGGCGGG	0.682000													13	66					0	0	0.004007	0	0
OR2D2	120776	broad.mit.edu	37	11	6913477	6913477	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:6913477C>A	ENST00000299459.2	-	1	353	c.255G>T	c.(253-255)ctG>ctT	p.L85L		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTCTGGAAAGCAGGTGGACTA	0.468000													9	52					0.000274275	0.000555806	0.004482	1	0
ITIH6	347365	broad.mit.edu	37	X	54823474	54823474	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:54823474G>A	ENST00000218436.6	-	2	187	c.158C>T	c.(157-159)aCc>aTc	p.T53I		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	53	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										GGTGACCAAGGTGTGGGCATA	0.473000													11	34					0	0	0.000673	0	0
ATP13A3	79572	broad.mit.edu	37	3	194169313	194169313	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:194169313C>T	ENST00000439040.1	-	12	1814	c.1023G>A	c.(1021-1023)gtG>gtA	p.V341V	ATP13A3_ENST00000256031.4_Silent_p.V341V			Q9H7F0	AT133_HUMAN	ATPase type 13A3	341					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CTATTCCTTTCACATCCACTG	0.333000													11	53					0	0	0.000673	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830679	7830679	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:7830679G>C	ENST00000327325.5	+	4	488	c.370G>C	c.(370-372)Ggt>Cgt	p.G124R	CLEC4M_ENST00000334806.5_Missense_Mutation_p.G96R|CLEC4M_ENST00000359059.5_Missense_Mutation_p.G103R|CLEC4M_ENST00000597522.1_Missense_Mutation_p.G124R|CLEC4M_ENST00000596363.1_Missense_Mutation_p.G96R|CLEC4M_ENST00000596707.1_Missense_Mutation_p.G103R|CLEC4M_ENST00000248228.4_Splice_Site_p.V124_splice|CLEC4M_ENST00000595496.1_Missense_Mutation_p.G103R|CLEC4M_ENST00000357361.2_Missense_Mutation_p.G124R|CLEC4M_ENST00000394122.2_Missense_Mutation_p.G112R	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	124	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						GGCTGCAGTGGGTGAGTTGCC	0.562000													26	153					0	0	0.002445	0	0
LRRC46	90506	broad.mit.edu	37	17	45914142	45914142	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:45914142C>A	ENST00000269025.4	+	8	985	c.622C>A	c.(622-624)Ctg>Atg	p.L208M		NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	208										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						GGAGCAGGAGCTGAGCAGGCA	0.687000													5	41					0.00116845	0.00233689	0.001168	1	0
MTMR3	8897	broad.mit.edu	37	22	30412531	30412531	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:30412531G>A	ENST00000333027.3	+	15	1846	c.1518G>A	c.(1516-1518)caG>caA	p.Q506Q	MTMR3_ENST00000406629.1_Silent_p.Q506Q|MTMR3_ENST00000401950.2_Silent_p.Q506Q|MTMR3_ENST00000351488.3_Silent_p.Q506Q|MTMR3_ENST00000323630.5_Silent_p.Q370Q|CTA-85E5.10_ENST00000429350.1_RNA	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	506	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			AACTGGTGCAGCATACCTATT	0.478000													39	120					0	0	0.002522	0	0
HOOK3	84376	broad.mit.edu	37	8	42868217	42868217	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:42868217A>T	ENST00000307602.4	+	20	2063	c.1863A>T	c.(1861-1863)aaA>aaT	p.K621N	HOOK3_ENST00000524839.1_3'UTR	NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	621	Required for association with Golgi.|Required for interaction with MSR1.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			TAGATCCTAAACAGAATCAAG	0.338000			T	RET	papillary thyroid								6	22					0	0	0.001168	0	0
ABCA7	10347	broad.mit.edu	37	19	1043352	1043352	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:1043352G>C	ENST00000263094.6	+	9	1041	c.810G>C	c.(808-810)ctG>ctC	p.L270L	ABCA7_ENST00000435683.2_Silent_p.L132L|ABCA7_ENST00000433129.1_Silent_p.L270L	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	270					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity	p.L270L(1)		NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCGGAGCTGATTGGAGCCC	0.627000													12	79					0	0	0.001855	0	0
BAI3	577	broad.mit.edu	37	6	70040462	70040462	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:70040462C>T	ENST00000370598.1	+	23	3921	c.3100C>T	c.(3100-3102)Ctg>Ttg	p.L1034L	BAI3_ENST00000238918.8_Silent_p.L240L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1034					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CGCTGTTGTCCTGGTAAACAT	0.353000													5	26					0	0	0.001984	0	0
OR10A3	26496	broad.mit.edu	37	11	7960962	7960962	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:7960962C>T	ENST00000360759.3	-	1	179	c.106G>A	c.(106-108)Gtg>Atg	p.V36M		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGGTCACCACATAAATAACT	0.458000													16	43					0	0	0.004007	0	0
NOS2	4843	broad.mit.edu	37	17	26107912	26107912	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:26107912C>T	ENST00000313735.6	-	9	1118	c.885G>A	c.(883-885)tgG>tgA	p.W295*		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	295					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ACTTGGGCTTCCAGCCCAGGT	0.627000													11	39					0	0	0.000978	0	0
GPR142	350383	broad.mit.edu	37	17	72368159	72368159	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:72368159C>T	ENST00000335666.4	+	4	857	c.809C>T	c.(808-810)tCg>tTg	p.S270L		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	270						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CGGGCCGCCTCGTCCCCAGGC	0.657000													5	24					0	0	0.001168	0	0
DENND1A	57706	broad.mit.edu	37	9	126429310	126429310	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:126429310C>G	ENST00000373624.2	-	8	703	c.502G>C	c.(502-504)Gag>Cag	p.E168Q	DENND1A_ENST00000394215.2_Missense_Mutation_p.E138Q|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000373618.1_Missense_Mutation_p.E136Q|DENND1A_ENST00000394219.3_Missense_Mutation_p.E136Q|DENND1A_ENST00000373620.3_Missense_Mutation_p.E168Q	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	168	DENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CTTACATTCTCAGGTATGCTG	0.299000													5	31					0	0	0.000602	0	0
GPM6A	2823	broad.mit.edu	37	4	176573010	176573010	+	Silent	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:176573010A>G	ENST00000280187.7	-	5	561	c.516T>C	c.(514-516)aaT>aaC	p.N172N	GPM6A_ENST00000393658.2_Silent_p.N172N|GPM6A_ENST00000506894.1_Silent_p.N161N|GPM6A_ENST00000515090.1_Silent_p.N165N	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	172						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		CCAAGCAGAGATTTGCTCCCT	0.463000													10	74					0	0	0.000978	0	0
COL22A1	169044	broad.mit.edu	37	8	139614357	139614357	+	Splice_Site	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:139614357C>A	ENST00000303045.6	-	60	4632		c.e60+1		COL22A1_ENST00000341807.4_Splice_Site|COL22A1_ENST00000435777.1_Splice_Site	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCTCCACTCACCCTTTCTCCT	0.572000										HNSCC(7;0.00092)			20	61					5.35267e-07	1.14529e-06	0.000958	1	0
SLC30A8	169026	broad.mit.edu	37	8	118183329	118183329	+	Missense_Mutation	SNP	G	G	T	rs139489847		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:118183329G>T	ENST00000427715.2	+	10	1173	c.739G>T	c.(739-741)Ggg>Tgg	p.G247W	SLC30A8_ENST00000519688.1_Missense_Mutation_p.G247W|SLC30A8_ENST00000456015.2_Missense_Mutation_p.G296W|SLC30A8_ENST00000521243.1_Missense_Mutation_p.G247W	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	296					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity	p.G296R(1)		breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			AGCAGTCGACGGGGTGCTGTC	0.448000													14	85					1.49906e-05	3.12883e-05	0.002450	1	0
FNDC5	252995	broad.mit.edu	37	1	33330273	33330273	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:33330273G>T	ENST00000373471.3	-	5	691	c.400C>A	c.(400-402)Cgc>Agc	p.R134S	FNDC5_ENST00000481487.1_5'UTR	NM_001171940.1|NM_153756.2	NP_001165411.1|NP_715637.1	Q8NAU1	FNDC5_HUMAN	fibronectin type III domain containing 5	193						integral to membrane|peroxisomal membrane				breast(1)|large_intestine(1)|lung(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCTTGCTGCGGAGAAGCCCC	0.577000													11	38					3.07112e-06	6.48065e-06	0.000978	1	0
FRMPD4	9758	broad.mit.edu	37	X	12736348	12736348	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:12736348G>A	ENST00000380682.1	+	16	3909	c.3403G>A	c.(3403-3405)Gat>Aat	p.D1135N		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1135					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						AGGAGCTCCTGATGGAGAAAC	0.512000													34	273					0	0	0.001287	0	0
EEA1	8411	broad.mit.edu	37	12	93196189	93196189	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:93196189T>C	ENST00000322349.8	-	19	2925	c.2661A>G	c.(2659-2661)atA>atG	p.I887M		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	887					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						CCAAGTCTAATATAGCGGCTT	0.289000													4	37					0	0	0.000602	0	0
RP1	6101	broad.mit.edu	37	8	55533682	55533682	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:55533682G>T	ENST00000220676.1	+	2	304	c.156G>T	c.(154-156)agG>agT	p.R52S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	52	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCGGGGTCAGGGTGGTGGTCA	0.557000													15	65					7.93312e-07	1.69269e-06	0.002450	1	0
MPPED1	758	broad.mit.edu	37	22	43821067	43821067	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:43821067G>C	ENST00000417669.1	+	2	520	c.76G>C	c.(76-78)Gca>Cca	p.A26P	MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000542779.1_Missense_Mutation_p.A26P|MPPED1_ENST00000443721.1_Missense_Mutation_p.A26P|MPPED1_ENST00000538182.1_Missense_Mutation_p.A59P			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	26							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CCTGGGCATGGCATTCTCCCA	0.697000													12	22					0	0	0.000978	0	0
PCDH1	5097	broad.mit.edu	37	5	141233941	141233941	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:141233941A>T	ENST00000287008.3	-	5	3527	c.3380T>A	c.(3379-3381)tTt>tAt	p.F1127Y	PCDH1_ENST00000503492.1_3'UTR	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	0					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		AGAGTGGCCAAACTCACTGCA	0.587000													8	21					0	0	0.003080	0	0
MARCH1	55016	broad.mit.edu	37	4	164466767	164466767	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:164466767G>C	ENST00000503008.1	-	7	1528	c.552C>G	c.(550-552)atC>atG	p.I184M	MARCH1_ENST00000339875.5_Missense_Mutation_p.I167M|MARCH1_ENST00000514618.1_Missense_Mutation_p.I440M|MARCH1_ENST00000274056.7_Missense_Mutation_p.I184M	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	184					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGCCTTGCTTGATTTCCTCCG	0.438000													3	39					0	0	0.004672	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99124010	99124010	+	Silent	SNP	A	A	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:99124010A>G	ENST00000394170.2	+	6	1598	c.1347A>G	c.(1345-1347)ctA>ctG	p.L449L	ZKSCAN5_ENST00000451158.1_Silent_p.L449L|ZKSCAN5_ENST00000326775.5_Silent_p.L449L	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	449					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TCGAACACCTAAAACGCCACT	0.502000													54	173					0	0	0.003610	0	0
AP3M2	10947	broad.mit.edu	37	8	42024827	42024827	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:42024827G>A	ENST00000518421.1	+	8	1240	c.949G>A	c.(949-951)Ggg>Agg	p.G317R	AP3M2_ENST00000520685.1_Intron|AP3M2_ENST00000174653.3_Missense_Mutation_p.G317R|AP3M2_ENST00000396926.3_Missense_Mutation_p.G317R	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	317	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GATGCCCAAGGGGGTCCTGAA	0.522000													11	47					0	0	0.001368	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498200	73498200	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:73498200C>A	ENST00000321617.3	-	18	3541	c.2955G>T	c.(2953-2955)acG>acT	p.T985T	CASKIN2_ENST00000433559.2_Silent_p.T903T	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	985	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGTCTGATTCCGTGAGGTTGA	0.667000													17	71					4.96729e-08	1.08095e-07	0.001216	1	0
MUC16	94025	broad.mit.edu	37	19	9056573	9056573	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:9056573G>A	ENST00000397910.4	-	3	31076	c.30873C>T	c.(30871-30873)acC>acT	p.T10291T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10293	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACTCCAGTGGTGGCAAATG	0.517000													10	92					0	0	0.001368	0	0
ZMYM1	79830	broad.mit.edu	37	1	35580175	35580175	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:35580175G>C	ENST00000373330.1	+	11	2918	c.2744G>C	c.(2743-2745)gGa>gCa	p.G915A	ZMYM1_ENST00000359858.4_Missense_Mutation_p.G915A|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	915						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATCTGGGATGGAACAGAGGAA	0.294000													4	19					0	0	0.000248	0	0
FBXW7	55294	broad.mit.edu	37	4	153247311	153247311	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:153247311C>T	ENST00000281708.4	-	10	2720	c.1491G>A	c.(1489-1491)ttG>ttA	p.L497L	FBXW7_ENST00000393956.3_Silent_p.L321L|FBXW7_ENST00000603548.1_Silent_p.L497L|FBXW7_ENST00000263981.5_Silent_p.L417L|FBXW7_ENST00000603841.1_Silent_p.L497L|FBXW7_ENST00000296555.5_Silent_p.L379L	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	497					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CATGACCCATCAAAACATGTA	0.453000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								5	74					0	0	0.001984	0	0
LPHN1	22859	broad.mit.edu	37	19	14262129	14262129	+	Silent	SNP	A	A	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:14262129A>C	ENST00000340736.6	-	24	4278	c.3981T>G	c.(3979-3981)ggT>ggG	p.G1327G	CTB-55O6.12_ENST00000588658.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA|LPHN1_ENST00000361434.3_Silent_p.G1322G	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	1327					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCCGGTCAGCACCCCCGGGCC	0.716000													6	8					0	0	0.001984	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762243	130762243	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:130762243G>T	ENST00000392429.1	+	2	3054	c.676G>T	c.(676-678)Gtg>Ttg	p.V226L	TMEM200A_ENST00000296978.3_Missense_Mutation_p.V226L|TMEM200A_ENST00000545622.1_Missense_Mutation_p.V226L	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	226						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GGACAGCTCCGTGGAGGAGGA	0.488000													6	44					3.59834e-05	7.42945e-05	0.001168	1	0
PARD3	56288	broad.mit.edu	37	10	34420469	34420469	+	Silent	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:34420469C>G	ENST00000374789.3	-	23	3796	c.3471G>C	c.(3469-3471)ctG>ctC	p.L1157L	PARD3_ENST00000374794.3_Silent_p.L1045L|PARD3_ENST00000374790.3_Silent_p.L1097L|PARD3_ENST00000350537.4_Silent_p.L1111L|PARD3_ENST00000545693.1_Silent_p.L1141L|PARD3_ENST00000374788.3_Silent_p.L1154L|PARD3_ENST00000545260.1_Silent_p.L1067L|PARD3_ENST00000346874.4_Silent_p.L1120L	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1157					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				ATTCTTGCCTCAGACGCTGTA	0.433000													9	62					0	0	0.004482	0	0
CTNND2	1501	broad.mit.edu	37	5	11236806	11236806	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:11236806G>T	ENST00000304623.8	-	10	1947	c.1758C>A	c.(1756-1758)gcC>gcA	p.A586A	CTNND2_ENST00000511377.1_Silent_p.A495A|CTNND2_ENST00000458100.2_Silent_p.A153A|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Silent_p.A249A|CTNND2_ENST00000359640.2_Silent_p.A586A	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	586					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CACTGACCTCGGCTTTAATTT	0.443000													27	115					2.79863e-10	6.25001e-10	0.004656	1	0
SPTBN2	6712	broad.mit.edu	37	11	66454925	66454925	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:66454925T>C	ENST00000533211.1	-	35	7026	c.6695A>G	c.(6694-6696)gAg>gGg	p.E2232G	SPTBN2_ENST00000529997.1_Missense_Mutation_p.E2232G|SPTBN2_ENST00000309996.2_Missense_Mutation_p.E2232G			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2232	PH.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CCCGAAGGCCTCCATCTCCTG	0.642000													3	93					0	0	0.004672	0	0
OS9	10956	broad.mit.edu	37	12	58090152	58090152	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:58090152T>G	ENST00000315970.7	+	5	616	c.575T>G	c.(574-576)gTt>gGt	p.V192G	OS9_ENST00000552285.1_Missense_Mutation_p.V192G|OS9_ENST00000257966.8_Missense_Mutation_p.V192G|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000389146.6_Missense_Mutation_p.V192G|OS9_ENST00000413095.2_Intron|OS9_ENST00000389142.5_Missense_Mutation_p.V192G|OS9_ENST00000551035.1_Intron|OS9_ENST00000439210.2_Missense_Mutation_p.V133G|OS9_ENST00000435406.2_Intron	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	192					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GAGGCCGAGGTTCGGGTGAGT	0.592000													12	52					0	0	0.000978	0	0
JRK	8629	broad.mit.edu	37	8	143747266	143747266	+	RNA	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:143747266G>C	ENST00000507178.2	-	0	544									jerky homolog (mouse)													all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				cgccttgttggagtccgagct	0.652000													4	19					0	0	0.000602	0	0
ABCC8	6833	broad.mit.edu	37	11	17482165	17482165	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:17482165G>T	ENST00000302539.4	-	6	1006	c.881C>A	c.(880-882)gCc>gAc	p.A294D	ABCC8_ENST00000389817.3_Missense_Mutation_p.A294D	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	294					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCTCCCGAAGGCATGGCTGAG	0.642000													14	73					3.45872e-05	7.16048e-05	0.004007	1	0
LILRB1	10859	broad.mit.edu	37	19	55148286	55148286	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:55148286C>T	ENST00000396331.1	+	16	2267	c.1910C>T	c.(1909-1911)tCt>tTt	p.S637F	LILRB1_ENST00000396332.4_Missense_Mutation_p.S638F|LILRB1_ENST00000418536.2_Missense_Mutation_p.S621F|LILRB1_ENST00000396315.1_Missense_Mutation_p.S639F|AC009892.10_ENST00000456337.1_Intron|LILRB1_ENST00000396317.1_Missense_Mutation_p.S621F|LILRB1_ENST00000434867.2_Missense_Mutation_p.S637F|LILRB1_ENST00000324602.7_Missense_Mutation_p.S639F|LILRB1_ENST00000396327.3_Missense_Mutation_p.S638F|LILRB1_ENST00000427581.2_Missense_Mutation_p.S688F|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000448689.1_3'UTR|LILRB1_ENST00000396321.2_Missense_Mutation_p.S637F	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	637					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GAAGGGCCCTCTCCAGCTGTG	0.642000										HNSCC(37;0.09)			17	47					0	0	0.004990	0	0
AIF1L	83543	broad.mit.edu	37	9	133993218	133993218	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:133993218C>G	ENST00000372309.3	+	6	510	c.356C>G	c.(355-357)tCa>tGa	p.S119*	AIF1L_ENST00000372297.2_Nonsense_Mutation_p.S37*|AIF1L_ENST00000247291.3_Nonsense_Mutation_p.S93*|AIF1L_ENST00000372298.1_Nonsense_Mutation_p.S93*|AIF1L_ENST00000372312.3_Nonsense_Mutation_p.S98*|AIF1L_ENST00000372300.1_Nonsense_Mutation_p.S93*|AIF1L_ENST00000372301.2_Nonsense_Mutation_p.S37*|AIF1L_ENST00000372302.1_Nonsense_Mutation_p.S85*	NM_001185095.1	NP_001172024.1	Q9BQI0	AIF1L_HUMAN	allograft inflammatory factor 1-like	93						actin cytoskeleton|cytoplasm|focal adhesion|ruffle membrane	actin filament binding|calcium ion binding			lung(2)	2						AAGATGATCTCAGAGGTGACA	0.507000													8	69					0	0	0.000443	0	0
CFLAR	8837	broad.mit.edu	37	2	202005138	202005138	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:202005138C>T	ENST00000309955.2	+	5	1097	c.582C>T	c.(580-582)ctC>ctT	p.L194L	CFLAR_ENST00000423241.2_Silent_p.L194L|CFLAR-AS1_ENST00000415011.2_RNA|CFLAR_ENST00000457277.1_Silent_p.L194L|CFLAR_ENST00000494258.1_Silent_p.L98L|CFLAR_ENST00000342795.5_Silent_p.L194L|CFLAR-AS1_ENST00000474886.2_RNA|CFLAR_ENST00000479953.2_Silent_p.L98L|CFLAR_ENST00000341222.6_Silent_p.L194L|CFLAR_ENST00000341582.6_Silent_p.L194L|CFLAR_ENST00000440180.1_Silent_p.L194L|CFLAR_ENST00000355558.4_Silent_p.L194L|CFLAR_ENST00000340870.5_Silent_p.L194L|CFLAR_ENST00000443227.1_Silent_p.L98L	NM_003879.5	NP_003870.4	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator	194	Interaction with FADD.|Interaction with TRAF1 and TRAF2.|Interaction with caspase-3.|Interaction with caspase-8 propeptide.|Interaction with caspase-8.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding	p.L194L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|stomach(1)	13						AAAAGAGTCTCAAGGATCCTT	0.388000													13	38					0	0	0.001855	0	0
ZNF639	51193	broad.mit.edu	37	3	179051458	179051458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:179051458C>T	ENST00000326361.3	+	7	1151	c.706C>T	c.(706-708)Cga>Tga	p.R236*	ZNF639_ENST00000466663.1_3'UTR|ZNF639_ENST00000496856.1_Nonsense_Mutation_p.R236*|ZNF639_ENST00000484866.1_Nonsense_Mutation_p.R236*	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	236					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AAATGTGTGTCGAGTATGCAA	0.353000													18	71					0	0	0.000958	0	0
SMARCC1	6599	broad.mit.edu	37	3	47712147	47712147	+	Splice_Site	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:47712147C>A	ENST00000254480.5	-	19	2019		c.e19+1		SMARCC1_ENST00000425518.1_Splice_Site	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		AATCTGCTTACCTCCAGGAGT	0.388000													5	20					0.00198382	0.00390644	0.001984	1	0
ELF2	1998	broad.mit.edu	37	4	139980635	139980635	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:139980635C>T	ENST00000394235.2	-	10	1750	c.1248G>A	c.(1246-1248)gcG>gcA	p.A416A	ELF2_ENST00000265495.4_Silent_p.A416A|ELF2_ENST00000379550.1_Silent_p.A428A|ELF2_ENST00000515489.1_Intron|ELF2_ENST00000510408.1_Silent_p.A356A|ELF2_ENST00000358635.3_Silent_p.A368A|ELF2_ENST00000379549.2_Silent_p.A339A	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	428					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.A416A(1)		endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					TTGGAGAGGTCGCTGTTGTTG	0.428000													12	34					0	0	0.000978	0	0
ANK3	288	broad.mit.edu	37	10	61815535	61815535	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:61815535C>G	ENST00000280772.1	-	42	13137	c.12946G>C	c.(12946-12948)Gaa>Caa	p.E4316Q	ANK3_ENST00000373827.2_Missense_Mutation_p.E1800Q|ANK3_ENST00000355288.2_Missense_Mutation_p.E940Q|ANK3_ENST00000503366.1_Missense_Mutation_p.E1807Q	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4316					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTAGTCTCTTCTATTATAAGC	0.438000													6	218					0	0	0.003080	0	0
POLRMT	5442	broad.mit.edu	37	19	619032	619032	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:619032C>T	ENST00000588649.2	-	15	3316	c.3232G>A	c.(3232-3234)Gtc>Atc	p.V1078I		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	1078	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGATGACGGGGACGCCC	0.632000													4	19					0	0	0.000248	0	0
TRGC1	6966	broad.mit.edu	37	7	38305125	38305125	+	RNA	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:38305125G>T	ENST00000443402.2	-	0	154					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					CCAGAATCGTGTTGCTCTTCT	0.418000													20	183					6.12954e-19	1.50007e-18	0.004656	1	0
MIPOL1	145282	broad.mit.edu	37	14	37754564	37754564	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:37754564G>T	ENST00000327441.7	+	8	1001	c.535G>T	c.(535-537)Gaa>Taa	p.E179*	MIPOL1_ENST00000556451.1_Nonsense_Mutation_p.E148*|MIPOL1_ENST00000537471.1_Nonsense_Mutation_p.E179*|MIPOL1_ENST00000539062.2_Nonsense_Mutation_p.E148*|MIPOL1_ENST00000536774.1_5'UTR|MIPOL1_ENST00000396294.2_Nonsense_Mutation_p.E179*|MIPOL1_ENST00000545536.1_Nonsense_Mutation_p.E148*	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	179										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		GGAACGTGATGAAGCTGTTAT	0.378000													14	79					1.02788e-11	2.39319e-11	0.004990	1	0
NALCN	259232	broad.mit.edu	37	13	101747987	101747987	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:101747987C>G	ENST00000251127.6	-	28	3288	c.3207G>C	c.(3205-3207)aaG>aaC	p.K1069N		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1069						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATTTAAGTTCTTTGACACAC	0.358000													9	47					0	0	0.004482	0	0
FSCB	84075	broad.mit.edu	37	14	44975773	44975773	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:44975773A>T	ENST00000340446.4	-	1	709	c.418T>A	c.(418-420)Tgg>Agg	p.W140R		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	140						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		ATCATGGTCCAGTATCCTGTA	0.423000													39	164					0	0	0.001951	0	0
OR4D11	219986	broad.mit.edu	37	11	59271774	59271774	+	Silent	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:59271774C>T	ENST00000313253.1	+	1	726	c.726C>T	c.(724-726)tcC>tcT	p.S242S		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						CTTGCACCTCCCACATCACTG	0.547000													28	160					0	0	0.005443	0	0
ABCD4	5826	broad.mit.edu	37	14	74761852	74761852	+	Splice_Site	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:74761852T>A	ENST00000356924.4	-	7	861	c.719_splice	c.e7+1	p.R240_splice	ABCD4_ENST00000298816.7_Intron|ABCD4_ENST00000557554.1_Intron|ABCD4_ENST00000557588.1_Splice_Site_p.S198_splice	NM_005050.3	NP_005041.1	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D (ALD), member 4	240	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			cervix(2)|endometrium(3)|kidney(3)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00153)		CAGACTCACCTGTAGAAAGCA	0.562000													17	54					0	0	0.001216	0	0
HEATR5B	54497	broad.mit.edu	37	2	37217854	37217854	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:37217854G>C	ENST00000233099.5	-	34	5729	c.5634C>G	c.(5632-5634)gtC>gtG	p.V1878V	HEATR5B_ENST00000354531.2_Silent_p.V1789V	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1878							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GTAATGACTGGACTCCTATTA	0.373000													10	47					0	0	0.000443	0	0
ZNF565	147929	broad.mit.edu	37	19	36673999	36673999	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:36673999C>T	ENST00000355114.5	-	5	1715	c.989G>A	c.(988-990)cGt>cAt	p.R330H	ZNF565_ENST00000304116.5_Missense_Mutation_p.R290H|ZNF565_ENST00000392173.2_Missense_Mutation_p.R290H			Q8N9K5	ZN565_HUMAN	zinc finger protein 565	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R290P(1)		large_intestine(4)|lung(4)|ovary(1)|skin(2)	11	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TTGGGAGCCACGAATGAAAGC	0.502000													14	81					0	0	0.003163	0	0
BCL6B	255877	broad.mit.edu	37	17	6930932	6930932	+	Silent	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:6930932G>T	ENST00000293805.5	+	9	1526	c.1434G>T	c.(1432-1434)ggG>ggT	p.G478G		NM_181844.3	NP_862827.1	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	478						nucleus	zinc ion binding			skin(1)	1						TTCTCGGGGGGCCCTAGCTGA	0.622000													11	48					1.61879e-10	3.63635e-10	0.001368	1	0
ARAP3	64411	broad.mit.edu	37	5	141033762	141033762	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:141033762C>G	ENST00000239440.4	-	33	4455	c.4390G>C	c.(4390-4392)Gag>Cag	p.E1464Q	ARAP3_ENST00000508305.1_Missense_Mutation_p.E1295Q|ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000513878.1_Missense_Mutation_p.E1113Q	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1464	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GGAGGGGGCTCAGGTGGCCTC	0.612000													15	48					0	0	0.002450	0	0
PI4KA	5297	broad.mit.edu	37	22	21064999	21064999	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:21064999T>C	ENST00000255882.6	-	52	6157	c.6071A>G	c.(6070-6072)tAc>tGc	p.Y2024C	PI4KA_ENST00000414196.3_Missense_Mutation_p.Y776C|PI4KA_ENST00000572273.1_Missense_Mutation_p.Y1966C	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1966					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CACAGCCAGGTAGCCTCGGAC	0.587000													40	171					0	0	0.002852	0	0
ALAD	210	broad.mit.edu	37	9	116155760	116155760	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:116155760T>C	ENST00000409155.3	-	2	276	c.80A>G	c.(79-81)aAt>aGt	p.N27S	ALAD_ENST00000277315.5_Missense_Mutation_p.N27S	NM_000031.5	NP_000022.3	P13716	HEM2_HUMAN	aminolevulinate dehydratase	27					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|stomach(1)	9					Aminolevulinic acid(DB00855)	GTTGGAGGCATTGAGGGTGGT	0.617000													11	39					0	0	0.001368	0	0
ATP10D	57205	broad.mit.edu	37	4	47559897	47559897	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:47559897G>C	ENST00000273859.3	+	12	2310	c.2041G>C	c.(2041-2043)Gag>Cag	p.E681Q	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	681					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CCAGGTGTGTGAGAGCCCCCA	0.552000													6	44					0	0	0.001984	0	0
FLT4	2324	broad.mit.edu	37	5	180057697	180057697	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:180057697G>A	ENST00000261937.6	-	3	336	c.258C>T	c.(256-258)ggC>ggT	p.G86G	FLT4_ENST00000502649.1_Silent_p.G86G|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Silent_p.G86G	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	86	Ig-like C2-type 1.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCGTCTGTGCCCTCGCAGT	0.632000													16	51					0	0	0.004007	0	0
PIK3R4	30849	broad.mit.edu	37	3	130463595	130463595	+	Silent	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:130463595G>A	ENST00000356763.3	-	2	1025	c.468C>T	c.(466-468)gtC>gtT	p.V156V		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	156	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						TCCAACTGGTGACCATCACAT	0.443000													14	84					0	0	0.002450	0	0
SOD3	6649	broad.mit.edu	37	4	24801160	24801160	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:24801160G>T	ENST00000382120.3	+	2	222	c.17G>T	c.(16-18)tGt>tTt	p.C6F		NM_003102.2	NP_003093.2	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular	6					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding			prostate(1)|urinary_tract(1)	2		Breast(46;0.0503)				GCGCTACTGTGTTCCTGCCTG	0.662000													3	13					0.004672	0.00908313	0.004672	1	0
DMD	1756	broad.mit.edu	37	X	31496268	31496268	+	Silent	SNP	G	G	C			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:31496268G>C	ENST00000357033.4	-	59	9098	c.8892C>G	c.(8890-8892)ggC>ggG	p.G2964G	DMD_ENST00000378707.3_Silent_p.G504G|DMD_ENST00000343523.2_Silent_p.G504G|DMD_ENST00000378677.2_Silent_p.G2960G|DMD_ENST00000359836.1_Silent_p.G504G|DMD_ENST00000541735.1_Silent_p.G504G|DMD_ENST00000474231.1_Silent_p.G504G	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2964					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGAGGAGATCGCCCACGGGCT	0.532000													4	28					0	0	0.000602	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530635	80530635	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:80530635C>G	ENST00000295057.3	-	2	966	c.310G>C	c.(310-312)Gtg>Ctg	p.V104L	CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000361291.4_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.V104L|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	104						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						TCCCCCTGCACGGAGCAGATG	0.597000										HNSCC(69;0.2)			22	110					0	0	0.002299	0	0
MYO3A	53904	broad.mit.edu	37	10	26414348	26414348	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:26414348G>A	ENST00000265944.5	+	19	2091	c.1925G>A	c.(1924-1926)cGg>cAg	p.R642Q	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	642	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.R642L(1)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CTTTGCATTCGGGCAGATGAG	0.418000													66	40					0	0	0.003610	0	0
LDB2	9079	broad.mit.edu	37	4	16760821	16760821	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:16760821T>A	ENST00000502640.1	-	2	343	c.195A>T	c.(193-195)ttA>ttT	p.L65F	LDB2_ENST00000441778.2_Missense_Mutation_p.L65F|LDB2_ENST00000515064.1_Missense_Mutation_p.L65F|LDB2_ENST00000304523.5_Missense_Mutation_p.L65F			O43679	LDB2_HUMAN	LIM domain binding 2	65							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						ATGAAAGGGTTAATGTGGCGT	0.388000													11	47					0	0	0.000673	0	0
NLRP14	338323	broad.mit.edu	37	11	7064307	7064307	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:7064307G>A	ENST00000299481.4	+	4	1396	c.1050G>A	c.(1048-1050)atG>atA	p.M350I		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	350	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGTGGGCCATGAAAGTATTCA	0.428000													15	87					0	0	0.003163	0	0
AQP11	282679	broad.mit.edu	37	11	77301379	77301379	+	Silent	SNP	C	C	A			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:77301379C>A	ENST00000313578.3	+	1	700	c.342C>A	c.(340-342)ccC>ccA	p.P114P	AQP11_ENST00000528638.1_Intron	NM_173039.2	NP_766627.1	Q8NBQ7	AQP11_HUMAN	aquaporin 11	114						cell surface|integral to membrane	transporter activity			kidney(2)|large_intestine(1)|lung(5)	8	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GCATGTCCCCCGAGACGGGTG	0.607000													15	83					1.45105e-14	3.47345e-14	0.006122	1	0
GPR150	285601	broad.mit.edu	37	5	94957182	94957182	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:94957182delT	ENST00000380007.2	+	1	1401	c.1203delT	c.(1201-1203)ccfs	p.P401fs		NM_199243.1	NP_954713.1	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	401						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(2)	2		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		GGCCCCACCCTCATTATCACC	0.726													2	4	---	---	---	---					
DNAH8	1769	broad.mit.edu	37	6	38834618	38834618	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:38834618delT	ENST00000359357.3	+	45	6262	c.6008delT	c.(6007-6009)ctfs	p.L2003fs	DNAH8_ENST00000441566.1_Intron|DNAH8_ENST00000449981.2_Frame_Shift_Del_p.L2220fs					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTTACGTTCTTTACAAACTC	0.303													10	18	---	---	---	---					
TLE1	7088	broad.mit.edu	37	9	84199390	84199390	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:84199390delC	ENST00000376499.3	-	19	3242	c.2178delG	c.(2176-2178)cgfs	p.R726fs		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	726					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CATAGGGGGTCCGCCAAGCAT	0.453													15	87	---	---	---	---					
SSTR1	6751	broad.mit.edu	37	14	38679129	38679130	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:38679129_38679130insT	ENST00000267377.2	+	3	1152_1153	c.535_536insT	c.(535-537)gggfs	p.G179fs		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	179					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GGTAGTAAACCTGGGCGTGTGG	0.644													10	49	---	---	---	---					
FAM222B	55731	broad.mit.edu	37	17	27085655	27085655	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:27085655delG	ENST00000341217.5	-	3	1537	c.1322delC	c.(1321-1323)cafs	p.P441fs	FAM222B_ENST00000452648.3_Frame_Shift_Del_p.P441fs|FAM222B_ENST00000581407.1_Frame_Shift_Del_p.P441fs|FAM222B_ENST00000582266.1_3'UTR	NM_018182.2	NP_060652.2	Q8WU58	CQ063_HUMAN	family with sequence similarity 222, member B	441																	GTAGGCCAATGGGGCTGCCAT	0.612													11	30	---	---	---	---					
ZNF431	170959	broad.mit.edu	37	19	21365549	21365549	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:21365549delC	ENST00000311048.7	+	5	587	c.443delC	c.(442-444)tcfs	p.S148fs	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						AGAAAAGGCTCCGCAAGTGTA	0.358													9	55	---	---	---	---					
XKR3	150165	broad.mit.edu	37	22	17288660	17288660	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:17288660delA	ENST00000331428.5	-	2	406	c.304delT	c.(304-306)ggfs	p.W102fs		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	102						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGAATGTGCCAAAAAAGTAAT	0.333													18	55	---	---	---	---