Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDH10	57575	broad.mit.edu	37	4	134071659	134071659	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:134071659T>C	ENST00000264360.4	+	1	1190	c.364T>C	c.(364-366)Ttc>Ctc	p.F122L		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	122	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CCCCCCCTCTTTCCCGGAGCC	0.612000													16	86					0	0	0.004007	0	0
SPTA1	6708	broad.mit.edu	37	1	158596754	158596754	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:158596754A>G	ENST00000368148.3	-	41	5888	c.5708T>C	c.(5707-5709)aTa>aCa	p.I1903T	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.I1900T	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1903					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAGAGCCTCTATCTTGGAAGA	0.428000													29	97					0	0	0.007291	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26204885	26204885	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:26204885G>A	ENST00000360441.4	+	1	28	c.13G>A	c.(13-15)Ggc>Agc	p.G5S		NM_003545.3	NP_003536.1	P62805	H4_HUMAN	histone cluster 1, H4e	5					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding	p.G5C(1)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	18		all_hematologic(11;0.196)				GTCTGGTCGCGGCAAAGGCGG	0.517000													30	63					0	0	0.009535	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121496	27121496	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:27121496G>C	ENST00000288699.6	+	2	287	c.129G>C	c.(127-129)atG>atC	p.M43I	DPYSL5_ENST00000401478.1_Missense_Mutation_p.M43I	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	43					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGAGCTCATGATCCCTGGCG	0.577000													11	90					0	0	0.008291	0	0
TBC1D20	128637	broad.mit.edu	37	20	420957	420957	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:420957C>T	ENST00000354200.4	-	6	850	c.703G>A	c.(703-705)Gtc>Atc	p.V235I	TBC1D20_ENST00000461188.1_5'UTR	NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	235	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				AACCGCACGACGTGCCTGAAG	0.557000													8	48					0	0	0.003080	0	0
NFATC4	4776	broad.mit.edu	37	14	24842446	24842446	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:24842446C>T	ENST00000413692.2	+	5	1762	c.1618C>T	c.(1618-1620)Cgg>Tgg	p.R540W	NFATC4_ENST00000555167.1_Missense_Mutation_p.R12W|NFATC4_ENST00000554050.1_Missense_Mutation_p.R477W|NFATC4_ENST00000556279.1_Missense_Mutation_p.R509W|NFATC4_ENST00000424781.2_Missense_Mutation_p.R490W|NFATC4_ENST00000556169.1_Missense_Mutation_p.R465W|NFATC4_ENST00000539237.2_Missense_Mutation_p.R509W|NFATC4_ENST00000250373.4_Missense_Mutation_p.R477W|NFATC4_ENST00000555590.1_Missense_Mutation_p.R490W|NFATC4_ENST00000422617.3_Missense_Mutation_p.R465W|NFATC4_ENST00000557451.1_Missense_Mutation_p.R407W|NFATC4_ENST00000554344.1_Missense_Mutation_p.R407W|NFATC4_ENST00000555453.1_Missense_Mutation_p.R465W|NFATC4_ENST00000553708.1_Missense_Mutation_p.R477W|NFATC4_ENST00000554966.1_Missense_Mutation_p.R490W|NFATC4_ENST00000553879.1_Missense_Mutation_p.R407W|NFATC4_ENST00000554591.1_Missense_Mutation_p.R540W|NFATC4_ENST00000554661.1_Missense_Mutation_p.R407W|NFATC4_ENST00000556759.1_Missense_Mutation_p.R12W|NFATC4_ENST00000554473.1_Missense_Mutation_p.R12W|NFATC4_ENST00000553469.1_Missense_Mutation_p.R509W	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	477	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		AAGGAACCTGCGGCCTCATGC	0.567000													12	42					0	0	0.013537	0	0
HELB	92797	broad.mit.edu	37	12	66717930	66717930	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:66717930A>G	ENST00000247815.4	+	10	2524	c.2465A>G	c.(2464-2466)aAt>aGt	p.N822S		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	822					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TTTGCTAAAAATAAGCGTGAC	0.333000													11	42					0	0	0.003163	0	0
PCK2	5106	broad.mit.edu	37	14	24572431	24572431	+	Missense_Mutation	SNP	C	C	T	rs145351624		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:24572431C>T	ENST00000545054.2	+	9	1951	c.1033C>T	c.(1033-1035)Cgc>Tgc	p.R345C	PCK2_ENST00000559250.1_Missense_Mutation_p.R491C|PCK2_ENST00000561286.1_Missense_Mutation_p.R345C|PCK2_ENST00000216780.4_Missense_Mutation_p.R479C|PCK2_ENST00000558096.1_Intron|NRL_ENST00000561028.1_Intron			Q16822	PCKGM_HUMAN	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	479					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			breast(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(265;0.0184)		CAGCGCCATGCGCTCTGAGTC	0.572000													3	26					0	0	0.004672	0	0
HCRTR1	3061	broad.mit.edu	37	1	32089283	32089283	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:32089283C>T	ENST00000403528.2	+	7	1283	c.898C>T	c.(898-900)Ctg>Ttg	p.L300L	HCRTR1_ENST00000373706.5_Silent_p.L300L|HCRTR1_ENST00000468521.1_3'UTR|HCRTR1_ENST00000373705.1_Silent_p.L300L	NM_001525.2	NP_001516.2	O43613	OX1R_HUMAN	hypocretin (orexin) receptor 1	300					feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				breast(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	7		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		AGCCAAGATGCTGATGGTGGT	0.632000													8	46					0	0	0.003080	0	0
LRIG2	9860	broad.mit.edu	37	1	113661886	113661886	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:113661886T>G	ENST00000361127.4	+	17	2910	c.2712T>G	c.(2710-2712)gaT>gaG	p.D904E	LRIG2_ENST00000492207.1_3'UTR	NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	904						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TTTGCTCAGATTGTTATGACA	0.413000													23	80					0	0	0.016522	0	0
SUZ12P1	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	T	C	rs112064181	by1000genomes	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:29061941T>C	ENST00000582557.1	+	0	861																											TAGATTTCTTTGAACTCGGAA	0.303000													6	67					0	0	0.001168	0	0
DLGAP3	58512	broad.mit.edu	37	1	35365842	35365842	+	Silent	SNP	G	G	A	rs149715442		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:35365842G>A	ENST00000373347.1	-	4	1408	c.1140C>T	c.(1138-1140)acC>acT	p.T380T	DLGAP3_ENST00000235180.4_Silent_p.T380T			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	380					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane		p.T380T(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CCTTGCCACCGGTGGGGTAAC	0.612000													34	122					0	0	0.019004	0	0
MCM6	4175	broad.mit.edu	37	2	136610440	136610440	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:136610440T>C	ENST00000264156.2	-	12	1732	c.1672A>G	c.(1672-1674)Aga>Gga	p.R558G	MCM6_ENST00000492091.1_Intron	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	558					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCCTCAATTCTTGAATGCAAA	0.368000													22	38					0	0	0.012319	0	0
REG3G	130120	broad.mit.edu	37	2	79254230	79254230	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:79254230C>T	ENST00000272324.5	+	4	450	c.266C>T	c.(265-267)tCc>tTc	p.S89F	REG3G_ENST00000409471.1_Intron|REG3G_ENST00000393897.2_Missense_Mutation_p.S89F	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	89	C-type lectin.				acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TCCTTCGTGTCCTCCCTGGTG	0.537000													21	106					0	0	0.012319	0	0
BSN	8927	broad.mit.edu	37	3	49700618	49700618	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:49700618G>T	ENST00000296452.4	+	7	11141	c.11027G>T	c.(11026-11028)cGc>cTc	p.R3676L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3676					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GACCTGGGTCGCCATGAGGCC	0.667000													8	26					0.00307968	0.00343164	0.003080	1	0
RNF14	9604	broad.mit.edu	37	5	141359811	141359811	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:141359811C>G	ENST00000394520.2	+	6	1267	c.958C>G	c.(958-960)Cag>Gag	p.Q320E	RNF14_ENST00000540015.1_Intron|AC005740.5_ENST00000520882.1_RNA|RNF14_ENST00000394515.3_Missense_Mutation_p.Q144E|RNF14_ENST00000347642.3_Missense_Mutation_p.Q320E|RNF14_ENST00000394519.1_Missense_Mutation_p.Q320E|RNF14_ENST00000356143.1_Missense_Mutation_p.Q320E|RNF14_ENST00000394514.2_Missense_Mutation_p.Q194E	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	320					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GCCTGTGATGCAGGAACCTGG	0.567000													59	31					0	0	0.014410	0	0
TSPYL6	388951	broad.mit.edu	37	2	54483229	54483229	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:54483229C>T	ENST00000317802.7	-	1	180	c.60G>A	c.(58-60)ccG>ccA	p.P20P	ACYP2_ENST00000303536.4_Intron|ACYP2_ENST00000606865.1_Intron|ACYP2_ENST00000394666.3_Intron|ACYP2_ENST00000607452.1_Intron	NM_001003937.2	NP_001003937.2	Q8N831	TSYL6_HUMAN	TSPY-like 6	20					nucleosome assembly	nucleus				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(1)|ovary(1)|skin(1)|stomach(2)	20						GGCCCTGGTGCGGGTCTTCCA	0.622000													28	124					0	0	0.007291	0	0
EID2	163126	broad.mit.edu	37	19	40030302	40030302	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:40030302G>A	ENST00000390658.2	-	1	568	c.418C>T	c.(418-420)Ctc>Ttc	p.L140F		NM_153232.3	NP_694964.3	Q8N6I1	EID2_HUMAN	EP300 interacting inhibitor of differentiation 2	140					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding			large_intestine(2)|lung(1)|urinary_tract(1)	4	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CGGAGACGGAGATAGGGCAAC	0.602000													24	102					0	0	0.016522	0	0
TIAM2	26230	broad.mit.edu	37	6	155485661	155485661	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:155485661C>A	ENST00000461783.3	+	10	3414	c.2141C>A	c.(2140-2142)gCa>gAa	p.A714E	TIAM2_ENST00000528391.2_Missense_Mutation_p.A26E|TIAM2_ENST00000529824.2_Missense_Mutation_p.A714E|TIAM2_ENST00000456144.1_Missense_Mutation_p.A714E|TIAM2_ENST00000367174.2_Missense_Mutation_p.A66E|TIAM2_ENST00000318981.5_Missense_Mutation_p.A714E|TIAM2_ENST00000456877.2_Missense_Mutation_p.A26E|TIAM2_ENST00000360366.4_Missense_Mutation_p.A714E			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	714					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGTCTCCTTGCAGCCGCCAGC	0.552000													80	148					5.82419e-33	6.95337e-33	0.014410	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:21971186G>A	ENST00000304494.5	-	2	442	c.172C>T	c.(172-174)Cga>Tga	p.R58*	CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P72L|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R7*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P113L|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P72L|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R7*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	58			R -> Q (in dbSNP:rs36204273).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R58*(78)|p.?(45)|p.M53_R58del(3)|p.P113L(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*88(2)|p.0(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.P113fs*>61(1)|p.R58fs*62(1)|p.R58fs*61(1)|p.G55fs*86(1)|p.R58R(1)|p.A57fs*85(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0.006214	0	0
ASTN1	460	broad.mit.edu	37	1	176998825	176998825	+	Silent	SNP	G	G	A	rs61758728		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:176998825G>A	ENST00000367654.2	-	5	1078	c.1065C>T	c.(1063-1065)aaC>aaT	p.N355N	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000361833.2_Silent_p.N355N|ASTN1_ENST00000367657.3_Silent_p.N355N|ASTN1_ENST00000424564.2_Silent_p.N355N			O14525	ASTN1_HUMAN	astrotactin 1	355					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GCTGGGGGTCGTTTTCTGCCT	0.507000													17	13					0	0	0.007413	0	0
INTS1	26173	broad.mit.edu	37	7	1523644	1523644	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:1523644T>C	ENST00000389470.4	-	26	3909	c.3910A>G	c.(3910-3912)Agc>Ggc	p.S1304G	INTS1_ENST00000404767.3_Missense_Mutation_p.S1142G			Q8N201	INT1_HUMAN	integrator complex subunit 1	1142					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTCACCCAGCTGTAGACCTCC	0.687000													14	55					0	0	0.007413	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:29628251A>G	ENST00000278882.3	+	6	633	c.253A>G	c.(253-255)Aat>Gat	p.N85D	FRG1B_ENST00000358464.4_Missense_Mutation_p.N85D|FRG1B_ENST00000439954.2_Missense_Mutation_p.N90D														p.N85D(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTGGCCTCAAATAGCTGCTT	0.358000													6	59					0	0	0.006214	0	0
LCT	3938	broad.mit.edu	37	2	136566782	136566782	+	Silent	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:136566782G>A	ENST00000264162.2	-	8	3145	c.3135C>T	c.(3133-3135)taC>taT	p.Y1045Y		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1045	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AAAAGTCTGCGTAGCTGTCAA	0.493000													28	55					0	0	0.007291	0	0
NEDD4L	23327	broad.mit.edu	37	18	55996286	55996286	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr18:55996286G>A	ENST00000456986.1	+	10	977	c.377G>A	c.(376-378)cGg>cAg	p.R126Q	NEDD4L_ENST00000400345.3_Missense_Mutation_p.R247Q|NEDD4L_ENST00000356462.6_Missense_Mutation_p.R247Q|NEDD4L_ENST00000456173.2_Missense_Mutation_p.R126Q|NEDD4L_ENST00000256832.7_Missense_Mutation_p.R126Q|NEDD4L_ENST00000435432.2_Missense_Mutation_p.R126Q|NEDD4L_ENST00000256830.9_Missense_Mutation_p.R247Q|NEDD4L_ENST00000586263.1_Missense_Mutation_p.R239Q|NEDD4L_ENST00000357895.5_Missense_Mutation_p.R239Q|NEDD4L_ENST00000431212.2_Missense_Mutation_p.R126Q|NEDD4L_ENST00000382850.4_Missense_Mutation_p.R247Q|NEDD4L_ENST00000589054.1_Intron	NM_001144964.1	NP_001138436.1	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	247					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						GCAGCACACCGGCGCTTCCGC	0.602000													22	14					0	0	0.014323	0	0
NSD1	64324	broad.mit.edu	37	5	176709563	176709563	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:176709563A>G	ENST00000439151.2	+	19	6035	c.5990A>G	c.(5989-5991)tAt>tGt	p.Y1997C	NSD1_ENST00000361032.4_Missense_Mutation_p.Y1894C|NSD1_ENST00000354179.4_Missense_Mutation_p.Y1728C|NSD1_ENST00000347982.4_Missense_Mutation_p.Y1728C	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1997	S-adenosyl-L-methionine binding.|SET.		Y -> C (in WES).		negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACTAATTTCTATATGCTCACC	0.373000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			50	21					0	0	0.014410	0	0
TRPS1	7227	broad.mit.edu	37	8	116430580	116430580	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:116430580C>G	ENST00000395715.3	-	6	3378	c.2801G>C	c.(2800-2802)gGc>gCc	p.G934A	TRPS1_ENST00000220888.5_Missense_Mutation_p.G921A|TRPS1_ENST00000520276.1_Missense_Mutation_p.G925A|TRPS1_ENST00000519076.1_Missense_Mutation_p.G675A	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	921					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTGGTAGAGGCCACACGCGTT	0.483000									Langer-Giedion syndrome				137	31					0	0	0.014410	0	0
INTS1	26173	broad.mit.edu	37	7	1523641	1523641	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:1523641A>G	ENST00000389470.4	-	26	3912	c.3913T>C	c.(3913-3915)Tgg>Cgg	p.W1305R	INTS1_ENST00000404767.3_Missense_Mutation_p.W1143R			Q8N201	INT1_HUMAN	integrator complex subunit 1	1143					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCCCTCACCCAGCTGTAGACC	0.687000													14	55					0	0	0.006122	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	60					0	0	0.009096	0	0
NPY5R	4889	broad.mit.edu	37	4	164271702	164271702	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:164271702T>C	ENST00000515560.1	+	4	1799	c.277T>C	c.(277-279)Ttt>Ctt	p.F93L	NPY5R_ENST00000506953.1_Missense_Mutation_p.F93L|NPY5R_ENST00000338566.3_Missense_Mutation_p.F93L			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	93					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				GGTTGTGCTGTTTTGCTCACC	0.403000													66	148					0	0	0.014410	0	0
LILRB4	11006	broad.mit.edu	37	19	55175317	55175317	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:55175317G>C	ENST00000391736.1	+	5	491	c.176G>C	c.(175-177)cGt>cCt	p.R59P	LILRB4_ENST00000270452.2_Missense_Mutation_p.R59P|LILRB4_ENST00000430952.2_Missense_Mutation_p.R59P|LILRB4_ENST00000391734.3_Missense_Mutation_p.R59P|LILRB4_ENST00000391733.3_Missense_Mutation_p.R59P	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	59	Ig-like C2-type 1.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CGGGAGTACCGTCTGGATAAA	0.587000													37	118					0	0	0.019004	0	0
HDAC9	9734	broad.mit.edu	37	7	18975526	18975526	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:18975526T>G	ENST00000406451.3	+	23	3039	c.2889T>G	c.(2887-2889)gaT>gaG	p.D963E	HDAC9_ENST00000441542.2_Missense_Mutation_p.D966E|HDAC9_ENST00000432645.2_Missense_Mutation_p.D963E|HDAC9_ENST00000401921.1_Missense_Mutation_p.D922E	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	963	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCATCTGTGATGCATCAGAAG	0.438000													36	96					0	0	0.015359	0	0
H2AFJ	55766	broad.mit.edu	37	12	14927722	14927722	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:14927722C>T	ENST00000544848.1	+	1	453	c.318C>T	c.(316-318)ggC>ggT	p.G106G		NM_177925.2	NP_808760.1	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	106					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|central_nervous_system(1)|kidney(1)|ovary(1)|skin(1)	5						TCGCTCAGGGCGGCGTCCTGC	0.597000													4	108					0	0	0.009096	0	0
AATK	9625	broad.mit.edu	37	17	79108261	79108261	+	Silent	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:79108261G>A	ENST00000326724.4	-	2	120	c.96C>T	c.(94-96)ctC>ctT	p.L32L		NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	32						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCACCACGGCGAGGGAGGATG	0.677000													16	25					0	0	0.004990	0	0
TBC1D4	9882	broad.mit.edu	37	13	75873599	75873599	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr13:75873599C>G	ENST00000377636.3	-	17	3369	c.3023G>C	c.(3022-3024)tGt>tCt	p.C1008S	TBC1D4_ENST00000425511.1_Missense_Mutation_p.C172S|TBC1D4_ENST00000377625.2_Missense_Mutation_p.C945S|TBC1D4_ENST00000431480.2_Missense_Mutation_p.C1000S|TBC1D4_ENST00000478591.1_5'UTR	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1008	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GATCCCCTGACAGTATCCCAC	0.493000													7	120					0	0	0.001984	0	0
FMN2	56776	broad.mit.edu	37	1	240601400	240601400	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:240601400A>T	ENST00000319653.9	+	16	5180	c.4950A>T	c.(4948-4950)aaA>aaT	p.K1650N	FMN2_ENST00000545751.1_Missense_Mutation_p.K246N	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1650	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGAAACCAAAACTTGGAGAGA	0.383000													8	77					0	0	0.004482	0	0
IL1R2	7850	broad.mit.edu	37	2	102636165	102636165	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:102636165C>T	ENST00000332549.3	+	5	808	c.579C>T	c.(577-579)ctC>ctT	p.L193L	IL1R2_ENST00000393414.2_Silent_p.L193L|IL1R2_ENST00000441002.1_Silent_p.L193L	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	193	Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	CTCACTTACTCGTACACGATG	0.418000													9	21					0	0	0.004482	0	0
BICC1	80114	broad.mit.edu	37	10	60549208	60549208	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:60549208G>A	ENST00000373886.3	+	7	791	c.787G>A	c.(787-789)Gct>Act	p.A263T		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	263					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						TAACACTAGTGCTGTGAAGGT	0.328000													31	36					0	0	0.010818	0	0
MTRR	4552	broad.mit.edu	37	5	7873624	7873624	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:7873624C>T	ENST00000264668.2	+	3	379	c.349C>T	c.(349-351)Cgg>Tgg	p.R117W	MTRR_ENST00000502509.1_Intron|MTRR_ENST00000440940.2_Missense_Mutation_p.R90W|MTRR_ENST00000341013.6_Intron	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	117	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TGCTCACCTGCGGTATGGGTT	0.448000													17	69					0	0	0.007413	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218231	130218231	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:130218231G>T	ENST00000276211.5	+	5	943	c.598G>T	c.(598-600)Gcc>Tcc	p.A200S	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.A64S|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.A188S	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	200					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GGAAGACGGAGCCCTGCTGCT	0.463000													13	9					1.5842e-08	1.81717e-08	0.016723	1	0
EPN2	22905	broad.mit.edu	37	17	19188962	19188962	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:19188962C>T	ENST00000314728.5	+	4	1109	c.625C>T	c.(625-627)Cgc>Tgc	p.R209C	EPN2_ENST00000575595.1_Intron|EPN2_ENST00000395618.3_Intron|EPN2_ENST00000395620.2_Intron|EPN2_ENST00000571254.1_Intron|EPN2_ENST00000347697.2_Intron|EPN2_ENST00000395626.1_Missense_Mutation_p.R209C	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	209					endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					cccccagcaccgcacaggggc	0.697000													3	10					0	0	0.004672	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686715	68686715	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:68686715T>C	ENST00000361320.4	+	2	619	c.41T>C	c.(40-42)gTa>gCa	p.V14A	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	14						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						GGATCAGCTGTAGCACTGGTT	0.413000													22	28					0	0	0.014323	0	0
OR4C16	219428	broad.mit.edu	37	11	55339991	55339991	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55339991T>A	ENST00000314634.3	+	1	388	c.388T>A	c.(388-390)Tac>Aac	p.Y130N		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GCCCCTGCACTACATGACCAT	0.502000													61	95					0	0	0.014410	0	0
CUX1	1523	broad.mit.edu	37	7	101844779	101844779	+	Silent	SNP	C	C	T	rs150235372		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:101844779C>T	ENST00000360264.3	+	18	2255	c.2235C>T	c.(2233-2235)tcC>tcT	p.S745S	CUX1_ENST00000560541.1_Intron|CUX1_ENST00000546411.2_Silent_p.S632S|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292535.7_Silent_p.S734S|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000556210.1_Silent_p.S576S|CUX1_ENST00000550008.2_Silent_p.S678S|CUX1_ENST00000549414.2_Silent_p.S712S	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	734					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S734S(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CACCACTGTCCCAGAGTGACA	0.632000													22	318					0	0	0.016522	0	0
PRKRIR	5612	broad.mit.edu	37	11	76061960	76061960	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:76061960G>C	ENST00000260045.3	-	5	2339	c.2234C>G	c.(2233-2235)aCa>aGa	p.T745R		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	745					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity	p.T745R(1)		cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TGACTTACTTGTATAGAGTTT	0.313000													6	23					0	0	0.013537	0	0
DNAH17	8632	broad.mit.edu	37	17	76481086	76481086	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:76481086A>T	ENST00000389840.5	-	48	7595	c.7471T>A	c.(7471-7473)Tcg>Acg	p.S2491T	DNAH17_ENST00000585328.1_Missense_Mutation_p.S2500T|DNAH17_ENST00000586052.1_5'UTR|RP11-559N14.5_ENST00000585969.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTCCTCCCCGATTTCTTCTCC	0.632000													13	17					0	0	0.020292	0	0
IL9R	3581	broad.mit.edu	37	X	155233408	155233408	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:155233408A>G	ENST00000540897.1	+	5	493	c.425A>G	c.(424-426)cAc>cGc	p.H142R	IL9R_ENST00000424344.3_Silent_p.P86P|IL9R_ENST00000244174.5_Silent_p.P107P|IL9R_ENST00000369423.2_Missense_Mutation_p.H152R	NM_176786.1	NP_789743.2	Q01113	IL9R_HUMAN	interleukin 9 receptor	96					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCGTGCTGCCACCTGAGGCAG	0.607000													9	19					0	0	0.004482	0	0
MROH5	389690	broad.mit.edu	37	8	142445304	142445304	+	RNA	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:142445304G>A	ENST00000606664.1	+	0	660				MROH5_ENST00000430863.1_RNA																							TGCAGTAGCCGCCAGCGGAGC	0.667000													56	18					0	0	0.014410	0	0
DOLK	22845	broad.mit.edu	37	9	131708963	131708963	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:131708963T>G	ENST00000372586.3	-	1	935	c.620A>C	c.(619-621)cAg>cCg	p.Q207P	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	207					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						CTTGATGAGCTGGTTGAGGAC	0.542000													40	35					0	0	0.006230	0	0
NACA	4666	broad.mit.edu	37	12	57111165	57111165	+	Silent	SNP	A	A	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:57111165A>T	ENST00000454682.1	-	3	4430	c.4149T>A	c.(4147-4149)gcT>gcA	p.A1383A	NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						GAGGAGTCATAGCGGGACCTC	0.597000			T	BCL6	NHL								10	23					0	0	0.006214	0	0
TLCD1	116238	broad.mit.edu	37	17	27051713	27051713	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:27051713G>C	ENST00000292090.3	-	4	669	c.559C>G	c.(559-561)Cag>Gag	p.Q187E	TLCD1_ENST00000394933.3_Missense_Mutation_p.Q140E	NM_138463.3	NP_612472.1	Q96CP7	TLCD1_HUMAN	TLC domain containing 1	187	TLC.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|lung(2)	7	Lung NSC(42;0.00431)					AGGTAGGCCTGAGGGGCCAGG	0.502000													7	108					0	0	0.003080	0	0
KLHL7	55975	broad.mit.edu	37	7	23213806	23213806	+	Silent	SNP	C	C	T	rs142565112		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:23213806C>T	ENST00000322231.7	+	12	2074	c.1584C>T	c.(1582-1584)acC>acT	p.T528T	AC005082.1_ENST00000366347.4_Intron|KLHL7_ENST00000409689.1_Silent_p.T502T|KLHL7_ENST00000339077.4_Silent_p.T550T|KLHL7_ENST00000545443.1_Silent_p.T528T|KLHL7_ENST00000542558.1_Silent_p.T325T|KLHL7_ENST00000539124.1_Silent_p.T474T			Q8IXQ5	KLHL7_HUMAN	kelch-like family member 7	550						Golgi apparatus|nucleolus|plasma membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AATATAATACCGAAACAGACA	0.423000													27	46					0	0	0.009535	0	0
OR5L2	26338	broad.mit.edu	37	11	55594850	55594850	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55594850C>A	ENST00000378397.1	+	1	156	c.156C>A	c.(154-156)agC>agA	p.S52R		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				TTCAGGTCAGCTCTCGGCTCC	0.478000										HNSCC(27;0.073)			101	220					4.49162e-49	5.41773e-49	0.014410	1	0
EPHX1	2052	broad.mit.edu	37	1	226027611	226027611	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:226027611C>T	ENST00000366837.4	+	6	1000	c.804C>T	c.(802-804)ttC>ttT	p.F268F	EPHX1_ENST00000272167.5_Silent_p.F268F	NM_000120.3	NP_000111.1	P07099	HYEP_HUMAN	epoxide hydrolase 1, microsomal (xenobiotic)	268					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.197)					GACAGCGTTTCGGGAGGTTTC	0.552000													41	147					0	0	0.007835	0	0
SRRT	51593	broad.mit.edu	37	7	100484575	100484575	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:100484575G>A	ENST00000388793.4	+	14	2024	c.1804G>A	c.(1804-1806)Gag>Aag	p.E602K	SRRT_ENST00000457580.2_Missense_Mutation_p.E603K|SRRT_ENST00000432932.1_Missense_Mutation_p.E602K|SRRT_ENST00000347433.4_Missense_Mutation_p.E603K	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	603					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GGAGCGGGATGAGAAGTTGAT	0.647000													30	196					0	0	0.012213	0	0
POLD1	5424	broad.mit.edu	37	19	50906777	50906777	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:50906777G>C	ENST00000440232.2	+	10	1218	c.1165G>C	c.(1165-1167)Gac>Cac	p.D389H	POLD1_ENST00000595904.1_Missense_Mutation_p.D389H|POLD1_ENST00000599857.1_Missense_Mutation_p.D389H	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	389					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CCGTATCATGGACCCCGACGT	0.597000								DNA polymerases (catalytic subunits)					19	138					0	0	0.014323	0	0
MOV10L1	54456	broad.mit.edu	37	22	50546633	50546633	+	Missense_Mutation	SNP	G	G	A	rs147590689		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr22:50546633G>A	ENST00000262794.5	+	4	594	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Missense_Mutation_p.E171K|MOV10L1_ENST00000545383.1_Missense_Mutation_p.E171K|MOV10L1_ENST00000540615.1_Missense_Mutation_p.E151K	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	171					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding	p.E151K(1)|p.E171K(1)		breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GTGGAGCAGCGAAGCCACCTC	0.602000													7	19					0	0	0.003080	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435651	5435651	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:5435651C>T	ENST00000380419.3	-	4	1207	c.1170G>A	c.(1168-1170)gcG>gcA	p.A390A	TUBAL3_ENST00000479328.1_Silent_p.A350A	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	390					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						CCTCCACAATCGCCGTGGTGT	0.592000													31	46					0	0	0.010818	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777750	18777750	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:18777750C>A	ENST00000380548.4	+	19	3862	c.3523C>A	c.(3523-3525)Cag>Aag	p.Q1175K		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1175	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		AGCGGCCCAGCAGCTCTCAGC	0.692000													13	15					0.00136819	0.00153922	0.013537	1	0
DHX33	56919	broad.mit.edu	37	17	5357145	5357145	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:5357145G>A	ENST00000225296.3	-	7	1503	c.1303C>T	c.(1303-1305)Cag>Tag	p.Q435*	DHX33_ENST00000433302.3_Nonsense_Mutation_p.Q211*	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	435	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCCTACCTCTGGATCTCTGGC	0.562000													5	41					0	0	0.014758	0	0
COL4A4	1286	broad.mit.edu	37	2	227966581	227966581	+	Splice_Site	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:227966581C>A	ENST00000396625.3	-	16	1182	c.975_splice	c.e16+1	p.K325_splice	COL4A4_ENST00000329662.7_Splice_Site_p.K325_splice	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	325	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTACATTTACCTTTAATCCTG	0.318000													5	7					0.00116845	0.00132726	0.001168	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873697	91873697	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:91873697C>A	ENST00000373094.1	+	7	4647	c.3802C>A	c.(3802-3804)Cat>Aat	p.H1268N	PCDH11X_ENST00000298274.8_Missense_Mutation_p.H1231N|PCDH11X_ENST00000373088.1_Missense_Mutation_p.H1231N|PCDH11X_ENST00000373097.1_Missense_Mutation_p.H1258N|PCDH11X_ENST00000361655.2_Missense_Mutation_p.H1250N|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000406881.1_Missense_Mutation_p.H1260N	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1268					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TATTGCCCTCCATCGTAGTCA	0.562000													73	83					2.81854e-13	3.26504e-13	0.014410	1	0
GABRA2	2555	broad.mit.edu	37	4	46334667	46334667	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:46334667C>T	ENST00000510861.1	-	4	393	c.220G>A	c.(220-222)Gtg>Atg	p.V74M	GABRA2_ENST00000515082.1_Missense_Mutation_p.V74M|GABRA2_ENST00000514090.1_Missense_Mutation_p.V74M|GABRA2_ENST00000540012.1_Intron|GABRA2_ENST00000356504.1_Missense_Mutation_p.V74M|GABRA2_ENST00000507069.1_Missense_Mutation_p.V74M|GABRA2_ENST00000381620.4_Missense_Mutation_p.V74M			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	74					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAACTGGTCACGTAGATGTTA	0.343000													14	34					0	0	0.004007	0	0
BRINP3	339479	broad.mit.edu	37	1	190129849	190129849	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:190129849C>A	ENST00000367462.3	-	7	1364	c.1133G>T	c.(1132-1134)aGc>aTc	p.S378I	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.S276I	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		378						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CTTGCTAAGGCTAAAAAGCTT	0.393000													39	44					9.84934e-19	1.15237e-18	0.010771	1	0
GDA	9615	broad.mit.edu	37	9	74834409	74834409	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:74834409T>A	ENST00000358399.3	+	6	686	c.593T>A	c.(592-594)aTg>aAg	p.M198K	GDA_ENST00000376989.3_Missense_Mutation_p.M173K|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000545168.1_Missense_Mutation_p.M124K|GDA_ENST00000376986.1_Missense_Mutation_p.M156K|GDA_ENST00000238018.4_Missense_Mutation_p.M198K	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	198					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GTGTCAGAAATGCTCCAAAAG	0.323000													10	15					0	0	0.016723	0	0
SYNE3	161176	broad.mit.edu	37	14	95921839	95921839	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:95921839T>G	ENST00000334258.5	-	5	1026	c.1012A>C	c.(1012-1014)Aag>Cag	p.K338Q	SYNE3_ENST00000557275.1_Missense_Mutation_p.K338Q|SYNE3_ENST00000554873.1_Missense_Mutation_p.K95Q|SYNE3_ENST00000553340.1_Missense_Mutation_p.K338Q	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						TCCAGCTGCTTAATCTGCTGC	0.667000													3	114					0	0	0.004672	0	0
REV1	51455	broad.mit.edu	37	2	100055565	100055565	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:100055565C>T	ENST00000258428.3	-	6	939	c.711G>A	c.(709-711)aaG>aaA	p.K237K	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Silent_p.K237K	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	237					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AATCCTGTGTCTTTAAGGCAC	0.512000								Direct reversal of damage					4	34					0	0	0.009096	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370532	38370532	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:38370532G>A	ENST00000322350.5	+	6	1026	c.680G>A	c.(679-681)cGc>cAc	p.R227H	EGFLAM_ENST00000354891.3_Missense_Mutation_p.R227H	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	227	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse		p.R227L(1)		NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CCCAGCCCCCGCAGCTGGCCC	0.577000													5	21					0	0	0.014758	0	0
ZNF780A	284323	broad.mit.edu	37	19	40581529	40581529	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:40581529C>T	ENST00000450241.2	-	6	1029	c.718G>A	c.(718-720)Gta>Ata	p.V240I	ZNF780A_ENST00000595687.2_Missense_Mutation_p.V274I|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000455521.1_Missense_Mutation_p.V275I|ZNF780A_ENST00000340963.5_Missense_Mutation_p.V274I|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000594395.1_Missense_Mutation_p.V275I			O75290	Z780A_HUMAN	zinc finger protein 780A	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGGTTTTACACCAGAATGA	0.388000													5	219					0	0	0.001168	0	0
DMD	1756	broad.mit.edu	37	X	31838157	31838157	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:31838157C>T	ENST00000357033.4	-	50	7450	c.7244G>A	c.(7243-7245)cGt>cAt	p.R2415H	DMD_ENST00000474231.1_5'UTR|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000378677.2_Missense_Mutation_p.R2411H|DMD_ENST00000359836.1_5'UTR|DMD_ENST00000343523.2_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2415					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGAAGTAAACGGTTTACCGC	0.428000													20	12					0	0	0.018920	0	0
TLE6	79816	broad.mit.edu	37	19	2987144	2987144	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:2987144A>G	ENST00000246112.4	+	7	650	c.449A>G	c.(448-450)aAg>aGg	p.K150R	TLE6_ENST00000452088.1_Missense_Mutation_p.K27R|TLE6_ENST00000478073.2_3'UTR	NM_001143986.1	NP_001137458.1	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	27					regulation of transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTGGGACAAGGAGCCTTGG	0.597000													19	89					0	0	0.007413	0	0
MTA2	9219	broad.mit.edu	37	11	62362870	62362870	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:62362870T>C	ENST00000278823.2	-	14	1738	c.1349A>G	c.(1348-1350)aAc>aGc	p.N450S	MTA2_ENST00000524902.1_Missense_Mutation_p.N277S|MTA2_ENST00000527204.1_Missense_Mutation_p.N277S	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	450					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						AGTTTGTCTGTTCTTAGCCAG	0.537000													69	71					0	0	0.014410	0	0
TMEM132D	121256	broad.mit.edu	37	12	130185156	130185156	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:130185156G>A	ENST00000422113.2	-	2	493	c.167C>T	c.(166-168)gCg>gTg	p.A56V		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	56						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGAGACGTCCGCGTTGTTGAT	0.557000													27	36					0	0	0.004656	0	0
HERC2	8924	broad.mit.edu	37	15	28389924	28389924	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr15:28389924C>T	ENST00000261609.7	-	72	11143	c.11035G>A	c.(11035-11037)Gag>Aag	p.E3679K		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3679					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATGCGCAGCTCGCTGGACCAG	0.572000													15	34					0	0	0.020292	0	0
TNFSF4	7292	broad.mit.edu	37	1	173155865	173155865	+	Silent	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:173155865G>A	ENST00000281834.3	-	3	478	c.342C>T	c.(340-342)aaC>aaT	p.N114N	TNFSF4_ENST00000367718.1_Silent_p.N64N	NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	114					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						GAAGGCTAATGTTGACTTCCT	0.468000													13	48					0	0	0.016723	0	0
WASH6P	653440	broad.mit.edu	37	X	155254983	155254983	+	RNA	SNP	G	G	C	rs140608299	by1000genomes	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:155254983G>C	ENST00000285718.7	+	0	1288				WASH6P_ENST00000461007.1_RNA																							CATCCCTCCTGTGCCCCCACC	0.647000													6	29					0	0	0.001984	0	0
AK9	221264	broad.mit.edu	37	6	109962806	109962806	+	Missense_Mutation	SNP	C	C	T	rs148448147	byFrequency	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:109962806C>T	ENST00000424296.2	-	10	924	c.848G>A	c.(847-849)cGa>cAa	p.R283Q	AK9_ENST00000341338.6_5'UTR|AK9_ENST00000285397.5_Missense_Mutation_p.R283Q|AK9_ENST00000368948.2_Missense_Mutation_p.R283Q	NM_001145128.2	NP_001138600.2			adenylate kinase 9									p.R283Q(2)									ATATTTAAGTCGATCCATAAC	0.348000													18	30					0	0	0.004990	0	0
LINC00969	440993	broad.mit.edu	37	3	195404651	195404651	+	RNA	SNP	C	C	G	rs1996904	by1000genomes	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:195404651C>G	ENST00000445430.1	+	0	1508																											TGTCACGAATCTTGACAAATT	0.418000													3	86					0	0	0.001984	0	0
AHR	196	broad.mit.edu	37	7	17382646	17382646	+	Missense_Mutation	SNP	A	A	T	rs146912085		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:17382646A>T	ENST00000242057.4	+	11	3148	c.2505A>T	c.(2503-2505)gaA>gaT	p.E835D		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	835				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATCCGTCAGAAGCCAGACCTT	0.373000													77	87					0	0	0.014410	0	0
SIRPG	55423	broad.mit.edu	37	20	1629753	1629753	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:1629753C>T	ENST00000381580.1	-	2	455	c.276G>A	c.(274-276)ggG>ggA	p.G92G	SIRPG_ENST00000344103.4_Silent_p.G125G|SIRPG_ENST00000381583.2_Silent_p.G125G|SIRPG_ENST00000216927.4_Silent_p.G125G|SIRPG_ENST00000303415.3_Silent_p.G125G			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	125	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						TCTCAGGGCTCCCTTTTCGAA	0.498000													55	83					0	0	0.014410	0	0
KLHL24	54800	broad.mit.edu	37	3	183368865	183368865	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:183368865G>A	ENST00000454652.1	+	4	1107	c.721G>A	c.(721-723)Gtt>Att	p.V241I	KLHL24_ENST00000476808.1_Missense_Mutation_p.V241I|KLHL24_ENST00000242810.6_Missense_Mutation_p.V241I			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	241	BACK.					axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CTATCGTGCCGTTGATCTGAG	0.418000													13	53					0	0	0.013537	0	0
WDR62	284403	broad.mit.edu	37	19	36550887	36550887	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:36550887T>G	ENST00000401500.2	+	3	322	c.287T>G	c.(286-288)tTg>tGg	p.L96W	WDR62_ENST00000388999.3_Missense_Mutation_p.L96W|WDR62_ENST00000270301.7_Missense_Mutation_p.L96W|WDR62_ENST00000378860.4_3'UTR	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	96					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTGGTGATTTTGGACCCCAAG	0.582000													3	156					0	0	0.009096	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102988373	102988373	+	Silent	SNP	A	A	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:102988373A>T	ENST00000375735.2	+	6	924	c.780A>T	c.(778-780)ggA>ggT	p.G260G	DYNC2H1_ENST00000398093.3_Silent_p.G260G|DYNC2H1_ENST00000334267.7_Silent_p.G260G	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	260	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GTTCATTTGGAAGGTTTGTTC	0.289000													11	356					0	0	0.013537	0	0
ABCF1	23	broad.mit.edu	37	6	30546133	30546133	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:30546133C>A	ENST00000326195.8	+	5	464	c.352C>A	c.(352-354)Cca>Aca	p.P118T	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Missense_Mutation_p.P118T	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	118					inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						AGTACCCGCCCCAAAACCCCG	0.498000													4	78					0.00909568	0.00994574	0.009096	1	0
ZNF24	7572	broad.mit.edu	37	18	32917689	32917689	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr18:32917689T>C	ENST00000261332.6	-	4	793	c.614A>G	c.(613-615)gAg>gGg	p.E205G	ZNF24_ENST00000399061.3_Missense_Mutation_p.E205G|ZNF24_ENST00000589881.1_3'UTR	NM_006965.2	NP_008896.2	P17028	ZNF24_HUMAN	zinc finger protein 24	205					myelination|negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	15						TGAAGGAAGCTCCTGCTTTGG	0.388000													56	42					0	0	0.014410	0	0
TRAV20	28663	broad.mit.edu	37	14	22508941	22508941	+	RNA	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:22508941C>A	ENST00000390448.3	+	0	102																											CATTCATAGTCTTGTGGCTTC	0.423000													51	41					4.88482e-21	5.77297e-21	0.014410	1	0
CHRDL1	91851	broad.mit.edu	37	X	109943927	109943927	+	Silent	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:109943927T>C	ENST00000218054.4	-	7	757	c.561A>G	c.(559-561)gaA>gaG	p.E187E	CHRDL1_ENST00000394797.4_Silent_p.E187E|CHRDL1_ENST00000434224.1_Silent_p.E108E|CHRDL1_ENST00000372042.1_Silent_p.E188E|CHRDL1_ENST00000482160.1_Silent_p.E108E|CHRDL1_ENST00000372045.1_Silent_p.E181E|CHRDL1_ENST00000444321.2_Silent_p.E187E	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	181					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						CATCAGAATGTTCCCATGACA	0.403000													12	28					0	0	0.013537	0	0
LRRC66	339977	broad.mit.edu	37	4	52862054	52862054	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:52862054C>T	ENST00000343457.3	-	4	1140	c.1134G>A	c.(1132-1134)gcG>gcA	p.A378A		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	378						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						ACAGGCACACCGCCAGAGCCA	0.562000													32	59					0	0	0.010818	0	0
ZBP1	81030	broad.mit.edu	37	20	56191333	56191333	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:56191333C>T	ENST00000340462.4	-	2	506	c.226G>A	c.(226-228)Gag>Aag	p.E76K	ZBP1_ENST00000371173.3_Missense_Mutation_p.E76K|ZBP1_ENST00000541799.1_Missense_Mutation_p.E76K|ZBP1_ENST00000538947.1_5'UTR|ZBP1_ENST00000395822.3_Intron|ZBP1_ENST00000343535.4_Missense_Mutation_p.E76K			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	76						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GCAGGACCCTCGCCTTCAGGA	0.607000													15	43					0	0	0.006122	0	0
CHD5	26038	broad.mit.edu	37	1	6202630	6202632	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:6202630_6202632delGAT	ENST00000262450.3	-	14	2176_2178	c.2077_2079delATC	c.(2077-2079)del	p.I693del	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	693					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTGTGGAGTCGATGTACCATGGC	0.635													18	72	---	---	---	---					
SPOCD1	90853	broad.mit.edu	37	1	32263807	32263824	+	Splice_Site	DEL	CCCTTTTCTCCTCCTGGT	CCCTTTTCTCCTCCTGGT	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:32263807_32263824delCCCTTTTCTCCTCCTGGT	ENST00000360482.2	-	9	2258_2275	c.2145_splice	c.e9+1	p.DQEEKRG710_splice	SPOCD1_ENST00000257100.3_Splice_Site_p.DQEEKRG203_splice|SPOCD1_ENST00000533231.1_Splice_Site_p.DQEEKRG710_splice|SPOCD1_ENST00000373648.2_3'UTR	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	710	TFIIS central.				transcription, DNA-dependent			p.E713K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCAGCACTCACCCTTTTCTCCTCCTGGTCCCGCCAGCG	0.624													8	64	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	33952117	33952117	+	RNA	DEL	A	A	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:33952117delA	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							AGACCTTGACAAAAACCAGGT	0.537													10	7	---	---	---	---					
RGPD4	285190	broad.mit.edu	37	2	108478175	108478175	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:108478175delA	ENST00000408999.3	+	15	2261	c.2184delA	c.(2182-2184)tcfs	p.S728fs	RGPD4_ENST00000354986.4_Frame_Shift_Del_p.S728fs	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	728					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						ACAGTGATTCAAATCTTTCAG	0.373													8	45	---	---	---	---					
NCL	4691	broad.mit.edu	37	2	232326373	232326378	+	In_Frame_Del	DEL	TCCTCG	TCCTCG	-	rs151176710	byFrequency	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:232326373_232326378delTCCTCG	ENST00000322723.4	-	3	726_731	c.486_491delCGAGGA	c.(484-492)gat>ga	p.DED162del		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	162	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ttcatcctcatcctcgtcctcgtcat	0.519													22	44	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149483094	149483094	+	RNA	DEL	G	G	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:149483094delG	ENST00000378016.2	+	0	3244							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			aagaagggctggaCAGGGGAG	0.537													5	2	---	---	---	---					
XKR5	389610	broad.mit.edu	37	8	6673270	6673270	+	RNA	DEL	A	A	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:6673270delA	ENST00000518724.1	-	0	1071							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		AGCCCATTGTAAAAAAAAAAA	0.502											OREG0018511	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
FIBCD1	84929	broad.mit.edu	37	9	133805423	133805423	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:133805423delC	ENST00000372338.4	-	2	325	c.83delG	c.(82-84)tcfs	p.C28fs	FIBCD1_ENST00000448616.1_Frame_Shift_Del_p.C28fs|FIBCD1_ENST00000372337.2_5'UTR|FIBCD1_ENST00000253018.4_5'UTR	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	28					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CACGTAGCCGCAGCTCGGCCG	0.682													2	4	---	---	---	---					
MKI67	4288	broad.mit.edu	37	10	129902204	129902205	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:129902204_129902205delTG	ENST00000368654.3	-	13	8274_8275	c.7899_7900delCA	c.(7897-7902)caaafs	p.HK2633fs	MKI67_ENST00000368653.3_Frame_Shift_Del_p.HK2273fs	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2633	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GCTGGTTCTTTGTGTGTGTGTG	0.500													7	110	---	---	---	---					
FOLR1	2348	broad.mit.edu	37	11	71903251	71903253	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:71903251_71903253delCTT	ENST00000393679.1	+	2	470_472	c.34_36delCTT	c.(34-36)del	p.L13del	FOLR1_ENST00000393676.3_In_Frame_Del_p.L13del|FOLR1_ENST00000393681.2_In_Frame_Del_p.L13del|FOLR1_ENST00000312293.4_In_Frame_Del_p.L13del|RP11-807H22.7_ENST00000378140.3_RNA			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	13					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						GCTGCTGCTCCTTCTAGTGTGGG	0.547													37	99	---	---	---	---					
PPL	5493	broad.mit.edu	37	16	4945271	4945272	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr16:4945271_4945272insT	ENST00000345988.2	-	11	1321_1322	c.1232_1233insA	c.(1231-1233)gggfs	p.G411fs	PPL_ENST00000590782.2_Frame_Shift_Ins_p.G409fs	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	411					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CCTGCTCCCCCTCAAAGTCACA	0.629													14	39	---	---	---	---					
CCDC124	115098	broad.mit.edu	37	19	18053527	18053529	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:18053527_18053529delGGA	ENST00000597436.1	+	3	329_331	c.222_224delGGA	c.(220-225)ctg>ct	p.LE74del	CCDC124_ENST00000445755.2_In_Frame_Del_p.LE74del	NM_138442.3	NP_612451.1	Q96CT7	CC124_HUMAN	coiled-coil domain containing 124	74							DNA binding			central_nervous_system(1)|kidney(2)	3						AGCGCCTACTGGAGGAGGAGGAC	0.675													2	4	---	---	---	---					
ZNF420	147923	broad.mit.edu	37	19	37619779	37619780	+	Frame_Shift_Ins	INS	-	-	T	rs142983916	by1000genomes	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:37619779_37619780insT	ENST00000337995.3	+	5	2101_2102	c.1886_1887insT	c.(1885-1887)cctfs	p.P629fs	ZNF420_ENST00000586540.1_3'UTR|CTC-454I21.4_ENST00000587645.1_RNA|ZNF585A_ENST00000588723.1_Intron|ZNF420_ENST00000304239.7_Intron	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	629					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGAGTTCACATCTTTCTCGGC	0.426													38	35	---	---	---	---