Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LRRC37A6P	387646	broad.mit.edu	37	10	27538842	27538842	+	RNA	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:27538842G>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							AGTCTCAGCTGGGGCCTCCTG	0.517000													40	80					2.32173e-10	2.52362e-10	1	1	0
DOCK7	85440	broad.mit.edu	37	1	63018486	63018486	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:63018486G>A	ENST00000251157.5	-	22	2716	c.2683C>T	c.(2683-2685)Cga>Tga	p.R895*	DOCK7_ENST00000340370.5_Nonsense_Mutation_p.R895*	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	895					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						CTAAGGCTTCGAGAACGATTT	0.453000													13	36					0	0	1	0	0
C16orf72	29035	broad.mit.edu	37	16	9210584	9210584	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:9210584C>T	ENST00000327827.7	+	4	1040	c.643C>T	c.(643-645)Cat>Tat	p.H215Y		NM_014117.2	NP_054836.2	Q14CZ0	CP072_HUMAN	chromosome 16 open reading frame 72	215										endometrium(4)|large_intestine(2)|lung(2)	8						CTCTCCTACACATGTAAGCAG	0.433000													24	98					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49094798	49094798	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:49094798A>G	ENST00000261900.3	-	4	653	c.431T>C	c.(430-432)tTa>tCa	p.L144S		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	144					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AAACTTACCTAAAGTCTGCAA	0.279000													6	28					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207200887	207200887	+	Silent	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:207200887G>T	ENST00000359470.5	-	2	306	c.57C>A	c.(55-57)gtC>gtA	p.V19V	C1orf116_ENST00000461135.2_Intron	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	19						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					CACAGCTGCCGACACGGGTCA	0.622000													7	88					0.00621372	0.00634053	1	1	0
HYPK	25764	broad.mit.edu	37	15	44093763	44093763	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr15:44093763T>A	ENST00000406925.1	+	4	4401	c.290T>A	c.(289-291)cTa>cAa	p.L97Q	SERF2_ENST00000594896.1_Missense_Mutation_p.L143Q|HYPK_ENST00000498605.1_3'UTR|HYPK_ENST00000458412.1_Silent_p.A78A|HYPK_ENST00000442995.2_Missense_Mutation_p.L97Q|SERF2_ENST00000600633.1_Missense_Mutation_p.L97Q					huntingtin interacting protein K														all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;8.1e-07)		GATCTGGAGCTAATAGTGAGT	0.403000													4	47					0	0	1	0	0
WT1	7490	broad.mit.edu	37	11	32417947	32417947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:32417947G>A	ENST00000332351.3	-	7	1389	c.1105C>T	c.(1105-1107)Cga>Tga	p.R369*	WT1_ENST00000448076.3_Nonsense_Mutation_p.R369*|WT1_ENST00000530998.1_Nonsense_Mutation_p.R140*|WT1_ENST00000379079.2_Nonsense_Mutation_p.R157*	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	301	Important for interaction with target DNA.		Q -> P (in DDS).		adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.R301*(5)|p.R301fs*16(5)|p.R301fs*7(5)|p.?(3)|p.R302fs*15(3)|p.R301fs*8(2)|p.R301fs*3(1)|p.R301fs*11(1)|p.R301fs*17(1)|p.V300fs*6(1)|p.R301fs*19(1)|p.R301fs*6(1)|p.D299fs*15(1)|p.R301fs*73(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GGCACACGTCGCACATCCTGC	0.522000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				13	28					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75065546	75065546	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr4:75065546G>T	ENST00000395759.2	+	4	514	c.487G>T	c.(487-489)Gcc>Tcc	p.A163S	MTHFD2L_ENST00000433372.1_Missense_Mutation_p.A28S|MTHFD2L_ENST00000325278.6_Missense_Mutation_p.A105S|MTHFD2L_ENST00000331145.6_Missense_Mutation_p.A105S	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	105					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			CAATGGAATTGCCCCAGAAAA	0.343000													18	50					5.35267e-07	5.72478e-07	1	1	0
COL4A5	1287	broad.mit.edu	37	X	107829872	107829872	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chrX:107829872A>G	ENST00000328300.6	+	19	1304	c.1060A>G	c.(1060-1062)Act>Gct	p.T354A	COL4A5_ENST00000361603.2_Missense_Mutation_p.T354A	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	354	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GACTGGTATAACTATAGGAGA	0.423000									Alport syndrome with Diffuse Leiomyomatosis				27	32					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62378317	62378317	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr20:62378317C>T	ENST00000245663.4	-	5	1886	c.1736G>A	c.(1735-1737)gGa>gAa	p.G579E	ZBTB46_ENST00000302995.2_Missense_Mutation_p.G579E|ZBTB46_ENST00000395104.1_Missense_Mutation_p.G579E	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GTCAGGGCCTCCTGGGGGGCT	0.716000													3	5					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48339631	48339631	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:48339631C>G	ENST00000221996.7	+	3	438	c.232C>G	c.(232-234)Ctg>Gtg	p.L78V	TPRX2P_ENST00000535362.1_Intron|CRX_ENST00000539067.1_Missense_Mutation_p.L78V	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	78					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GAAGATCAATCTGCCTGAGTC	0.607000													9	41					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31617900	31617900	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr7:31617900C>A	ENST00000409210.1	+	6	930	c.746C>A	c.(745-747)tCt>tAt	p.S249Y	CCDC129_ENST00000319386.3_Intron|CCDC129_ENST00000407970.3_Missense_Mutation_p.S341Y|CCDC129_ENST00000451887.2_Missense_Mutation_p.S367Y			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	341										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CCTTGCTCATCTATGCCGGCC	0.498000													4	23					1	1	1	1	0
DEF8	54849	broad.mit.edu	37	16	90016039	90016039	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:90016039G>A	ENST00000268676.7	+	2	255	c.166G>A	c.(166-168)Gag>Aag	p.E56K	DEF8_ENST00000570182.1_Intron|DEF8_ENST00000569453.1_Intron|DEF8_ENST00000563795.1_Intron|DEF8_ENST00000567874.1_Intron|DEF8_ENST00000418391.2_Intron|DEF8_ENST00000563594.1_Intron	NM_207514.2	NP_997397.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	56					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CAGGACGCGGGAGGCCAGGTC	0.667000													17	36					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47278812	47278812	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:47278812G>A	ENST00000542575.2	-	8	2209	c.1581C>T	c.(1579-1581)ccC>ccT	p.P527P	SLC1A5_ENST00000434726.2_Silent_p.P325P|SLC1A5_ENST00000412532.2_Silent_p.P299P|SLC1A5_ENST00000594991.1_Silent_p.P351P|FKRP_ENST00000600646.1_Intron	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	527					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CATCCCCTGCGGGCCCCCGAT	0.597000													38	145					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406478	55406478	+	Silent	SNP	T	T	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:55406478T>C	ENST00000314612.2	+	1	645	c.645T>C	c.(643-645)tcT>tcC	p.S215S		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						TGTTGTTGTCTTATGTTTTTA	0.378000													18	52					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148869524	148869524	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:148869524C>G	ENST00000367467.3	+	20	4049	c.3574C>G	c.(3574-3576)Ccc>Gcc	p.P1192A		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1192	SAM 2.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CATCGGTCTGCCCATGTACGC	0.572000													22	54					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99442718	99442718	+	Missense_Mutation	SNP	C	C	T	rs147236845		TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr15:99442718C>T	ENST00000268035.6	+	5	1726	c.1115C>T	c.(1114-1116)tCa>tTa	p.S372L	IGF1R_ENST00000558762.1_Missense_Mutation_p.S372L	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	372					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	AACATTGCTTCAGAGCTGGAG	0.458000													23	45					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905407	15905407	+	Silent	SNP	T	T	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:15905407T>C	ENST00000308940.8	+	1	647	c.549T>C	c.(547-549)ccT>ccC	p.P183P		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						ACGTGCCACCTCTGTTGAAGT	0.577000													7	75					0	0	1	0	0
CHP2	63928	broad.mit.edu	37	16	23768600	23768600	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:23768600G>A	ENST00000300113.2	+	6	916	c.493G>A	c.(493-495)Gat>Aat	p.D165N		NM_022097.2	NP_071380.1	O43745	CHP2_HUMAN	calcineurin-like EF-hand protein 2	165	EF-hand 4.						calcium ion binding			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|stomach(1)	9				GBM - Glioblastoma multiforme(48;0.0144)		GCAGGAGGCTGATGAAGATGG	0.567000													15	40					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67800669	67800669	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr13:67800669C>G	ENST00000544246.1	-	2	2595	c.1904G>C	c.(1903-1905)aGa>aCa	p.R635T	PCDH9_ENST00000377865.2_Missense_Mutation_p.R635T|PCDH9_ENST00000377861.3_Missense_Mutation_p.R635T|PCDH9_ENST00000328454.5_Missense_Mutation_p.R635T|PCDH9_ENST00000456367.1_Missense_Mutation_p.R635T	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	635	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CTGCTGCTCTCTATCAAATGA	0.403000													22	70					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219520928	219520928	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:219520928G>A	ENST00000411696.2	-	3	1004	c.225C>T	c.(223-225)atC>atT	p.I75I	ZNF142_ENST00000449707.1_Silent_p.I75I			P52746	ZN142_HUMAN	zinc finger protein 142	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TCTCCACAATGATCTCCATGT	0.592000													8	43					0	0	1	0	0
AURKAIP1	54998	broad.mit.edu	37	1	1309521	1309521	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:1309521G>A	ENST00000338370.3	-	2	757	c.357C>T	c.(355-357)gtC>gtT	p.V119V	AURKAIP1_ENST00000321751.5_Silent_p.V119V|AURKAIP1_ENST00000338338.5_Silent_p.V119V|AURKAIP1_ENST00000378853.3_Silent_p.V119V			Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	119					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding			kidney(1)|lung(2)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCGCATCCGCGACGCCTTCAT	0.612000													28	55					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130854238	130854238	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:130854238G>C	ENST00000373066.5	+	1	496	c.89G>C	c.(88-90)aGa>aCa	p.R30T	SLC25A25_ENST00000432073.2_Missense_Mutation_p.R30T|SLC25A25_ENST00000373069.5_Intron|SLC25A25_ENST00000373068.2_Intron|RP11-379C10.4_ENST00000453870.1_RNA	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	0					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						CGTGAAGTCAGAGGCACCCCA	0.582000													27	161					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125988597	125988597	+	Silent	SNP	A	A	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:125988597A>T	ENST00000319286.5	+	3	241	c.87A>T	c.(85-87)acA>acT	p.T29T		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CAGGAGATACAAGTATGAATA	0.328000										HNSCC(60;0.17)			11	70					0	0	1	0	0
UPF1	5976	broad.mit.edu	37	19	18963799	18963799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:18963799C>T	ENST00000262803.5	+	7	1248	c.976C>T	c.(976-978)Caa>Taa	p.Q326*	UPF1_ENST00000599848.1_Nonsense_Mutation_p.Q326*	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	326	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						TGCTCAGACTCAAGATAACAT	0.552000													17	52					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235922444	235922444	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:235922444G>A	ENST00000389794.3	-	23	6883	c.6709C>T	c.(6709-6711)Cag>Tag	p.Q2237*	LYST_ENST00000389793.2_Nonsense_Mutation_p.Q2237*			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2237					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGGCTTCGCTGGAAGGAGGCC	0.527000													37	53					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99799430	99799430	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr7:99799430C>G	ENST00000426455.1	+	22	2649	c.2242C>G	c.(2242-2244)Ctt>Gtt	p.L748V	STAG3_ENST00000394018.2_Missense_Mutation_p.L690V|GATS_ENST00000436886.2_3'UTR|GATS_ENST00000543273.1_RNA|STAG3_ENST00000440830.1_3'UTR|STAG3_ENST00000317296.5_Missense_Mutation_p.L748V			Q9UJ98	STAG3_HUMAN	stromal antigen 3	748					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCCTTGACTCTTGTCTATTT	0.448000													21	88					0	0	1	0	0
CDKN3	1033	broad.mit.edu	37	14	54868294	54868294	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr14:54868294C>A	ENST00000541304.1	+	3	185	c.145C>A	c.(145-147)Cca>Aca	p.P49T	CDKN3_ENST00000442975.2_Intron|CDKN3_ENST00000556102.2_Missense_Mutation_p.P49T|CDKN3_ENST00000556305.1_3'UTR|CDKN3_ENST00000458126.2_Missense_Mutation_p.P49T|CDKN3_ENST00000335183.6_Missense_Mutation_p.P49T|CDKN3_ENST00000543789.2_Missense_Mutation_p.P49T			Q16667	CDKN3_HUMAN	cyclin-dependent kinase inhibitor 3	49					cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(2)|stomach(1)	3						ATGTGCTCTTCCAGGTGGGTA	0.328000													15	44					1.01871e-10	1.11946e-10	1	1	0
PTPRK	5796	broad.mit.edu	37	6	128385918	128385918	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:128385918G>A	ENST00000368227.3	-	13	2545	c.2179C>T	c.(2179-2181)Cgc>Tgc	p.R727C	PTPRK_ENST00000368226.4_Missense_Mutation_p.R727C|RP11-103C16.2_ENST00000417390.1_RNA|PTPRK_ENST00000532331.1_Missense_Mutation_p.R727C|PTPRK_ENST00000368207.3_Missense_Mutation_p.R727C|PTPRK_ENST00000368215.3_Missense_Mutation_p.R727C|PTPRK_ENST00000368210.3_Missense_Mutation_p.R727C|PTPRK_ENST00000368213.5_Missense_Mutation_p.R727C|PTPRK_ENST00000524481.1_5'UTR			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	727					cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GTAGCAATGCGTACGCACTGG	0.343000													6	25					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119015147	119015147	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:119015147C>T	ENST00000298472.5	+	9	1017	c.874C>T	c.(874-876)Ccg>Tcg	p.P292S	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	292					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	GCTGAAGGACCCGTACATCCT	0.612000													5	23					0	0	1	0	0
AMOTL2	51421	broad.mit.edu	37	3	134089642	134089642	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:134089642G>C	ENST00000514516.1	-	2	986	c.808C>G	c.(808-810)Cag>Gag	p.Q270E	AMOTL2_ENST00000513145.1_Missense_Mutation_p.Q212E|AMOTL2_ENST00000511759.1_Intron|AMOTL2_ENST00000422605.2_Missense_Mutation_p.Q212E|AMOTL2_ENST00000249883.5_Missense_Mutation_p.Q212E	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	212										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						TGAGGGTACTGAGGTGGGGGT	0.662000													20	57					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98823366	98823366	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:98823366G>T	ENST00000266058.4	-	8	884	c.639C>A	c.(637-639)caC>caA	p.H213Q	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371041.3_Missense_Mutation_p.H213Q|SLIT1_ENST00000371070.4_Missense_Mutation_p.H213Q	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	213					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GGTGGTTGGAGTGCAGGCGGC	0.652000													3	16					6.4e-05	6.70157e-05	1	1	0
LIPI	149998	broad.mit.edu	37	21	15538724	15538724	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr21:15538724C>G	ENST00000344577.2	-	5	780	c.755G>C	c.(754-756)gGa>gCa	p.G252A	LIPI_ENST00000536861.1_Missense_Mutation_p.G231A	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	231					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTTATTTCCTCCATTTGGATA	0.338000													20	45					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16977298	16977298	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:16977298C>G	ENST00000379803.1	+	13	1847	c.1833C>G	c.(1831-1833)ttC>ttG	p.F611L	SIN3B_ENST00000595541.1_Missense_Mutation_p.F169L|SIN3B_ENST00000248054.5_Missense_Mutation_p.F579L	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	611					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CTGTGAACTTCAAGCAGAACG	0.597000													18	72					0	0	1	0	0
LIMS2	55679	broad.mit.edu	37	2	128396899	128396899	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:128396899G>A	ENST00000409455.1	-	10	1603	c.968C>T	c.(967-969)tCc>tTc	p.S323F	LIMS2_ENST00000545738.2_Missense_Mutation_p.S350F|LIMS2_ENST00000409808.2_Missense_Mutation_p.S323F|LIMS2_ENST00000409286.1_Missense_Mutation_p.S176F|LIMS2_ENST00000409754.1_Missense_Mutation_p.S176F|LIMS2_ENST00000324938.5_Missense_Mutation_p.S352F|LIMS2_ENST00000409254.1_Missense_Mutation_p.S176F|LIMS2_ENST00000410038.1_Missense_Mutation_p.S176F|LIMS2_ENST00000355119.4_Missense_Mutation_p.S328F|LIMS2_ENST00000410011.1_Missense_Mutation_p.S323F|LIMS2_ENST00000494613.1_5'UTR			Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	328					cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		GGCCTTGCGGGAGGTCAGCTC	0.612000													28	86					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214791936	214791936	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:214791936G>C	ENST00000366955.3	+	4	548	c.380G>C	c.(379-381)aGa>aCa	p.R127T		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	127	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GAGCTTGAAAGAAGCCAACAA	0.403000													44	59					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104161068	104161068	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:104161068G>A	ENST00000369966.3	+	19	2453	c.2203G>A	c.(2203-2205)Gac>Aac	p.D735N	NFKB2_ENST00000189444.6_Missense_Mutation_p.D735N|NFKB2_ENST00000428099.1_Missense_Mutation_p.D735N	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	735			Missing (in truncated form EB308).|Missing (in truncated form LB40).|Missing (in truncated form p80HT).		innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CACGCCTCTTGACCTCACTTG	0.597000			T	IGH@	B-NHL								24	56					0	0	1	0	0
IQCK	124152	broad.mit.edu	37	16	19745024	19745024	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:19745024C>A	ENST00000320394.6	+	4	950	c.251C>A	c.(250-252)gCg>gAg	p.A84E	IQCK_ENST00000541926.1_Missense_Mutation_p.A84E|IQCK_ENST00000433597.2_5'UTR|IQCK_ENST00000564186.1_Missense_Mutation_p.A84E	NM_153208.1	NP_694940.1	Q8N0W5	IQCK_HUMAN	IQ motif containing K	84										kidney(1)|large_intestine(2)|lung(2)|skin(1)	6						CTCCAGGTTGCGCCAGTAGAG	0.423000													24	81					3.01185e-09	3.23855e-09	1	1	0
EPS15	2060	broad.mit.edu	37	1	51864782	51864782	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:51864782G>C	ENST00000371733.3	-	20	2070	c.1974C>G	c.(1972-1974)ttC>ttG	p.F658L	EPS15_ENST00000396122.4_Missense_Mutation_p.F335L|EPS15_ENST00000371730.2_Missense_Mutation_p.F524L	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	658	15 X 3 AA repeats of D-P-F.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(2)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						ATTGCCTGAAGAAACAGTCTG	0.373000			T	MLL	ALL								18	62					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457400	110457400	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:110457400G>A	ENST00000378402.5	+	38	5406	c.5302G>A	c.(5302-5304)Gaa>Aaa	p.E1768K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1768	IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTTCTTATTGAAGGAGAAGG	0.403000										HNSCC(38;0.096)			16	75					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130536747	130536747	+	Splice_Site	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:130536747C>G	ENST00000314830.8	-	2	151		c.e2-1			NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C						JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTGAAGAACTCTAGCAGAGGG	0.478000													6	40					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70476248	70476248	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:70476248T>G	ENST00000260128.4	+	5	755	c.38T>G	c.(37-39)cTg>cGg	p.L13R	SULF1_ENST00000402687.4_Missense_Mutation_p.L13R|SULF1_ENST00000419716.3_Missense_Mutation_p.L13R|SULF1_ENST00000458141.2_Missense_Mutation_p.L13R	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	13					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTGGCTGTCCTGGGCACAGAA	0.468000													20	34					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68954653	68954653	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:68954653C>G	ENST00000456315.2	-	4	650	c.536G>C	c.(535-537)aGa>aCa	p.R179T	DEPDC1_ENST00000370966.5_Missense_Mutation_p.R179T	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	179					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		GCTTAGTTCTCTATTATCAAT	0.299000													11	41					0	0	1	0	0
TRDMT1	1787	broad.mit.edu	37	10	17199512	17199512	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:17199512G>T	ENST00000377799.3	-	8	862	c.815C>A	c.(814-816)tCa>tAa	p.S272*	TRDMT1_ENST00000377766.5_3'UTR|TRDMT1_ENST00000412821.3_Nonsense_Mutation_p.S248*|TRDMT1_ENST00000351358.4_Nonsense_Mutation_p.S226*|TRDMT1_ENST00000488990.1_Nonsense_Mutation_p.S149*|TRDMT1_ENST00000358282.7_3'UTR|TRDMT1_ENST00000452380.2_5'UTR|TRDMT1_ENST00000457442.2_Nonsense_Mutation_p.S191*	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	272					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						TCGCAGCAATGACTTTGGTGG	0.393000													14	51					9.05144e-12	1.00016e-11	1	1	0
CDH18	1016	broad.mit.edu	37	5	19571872	19571872	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr5:19571872G>A	ENST00000507958.1	-	10	2059	c.1069C>T	c.(1069-1071)Cgc>Tgc	p.R357C	CDH18_ENST00000511273.1_Missense_Mutation_p.R357C|CDH18_ENST00000506372.1_Missense_Mutation_p.R357C|CDH18_ENST00000274170.4_Missense_Mutation_p.R357C|CDH18_ENST00000502796.1_Missense_Mutation_p.R357C|CDH18_ENST00000382275.1_Missense_Mutation_p.R357C			Q13634	CAD18_HUMAN	cadherin 18, type 2	357	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R357C(1)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGAGAAAAGCGAAAATCAAGA	0.378000													15	59					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43096998	43096998	+	Silent	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:43096998C>T	ENST00000230419.4	+	2	584	c.363C>T	c.(361-363)atC>atT	p.I121I	PTK7_ENST00000352931.2_Silent_p.I121I|PTK7_ENST00000476760.1_Silent_p.I121I|PTK7_ENST00000471863.1_Silent_p.I121I|PTK7_ENST00000349241.2_Silent_p.I121I|PTK7_ENST00000345201.2_Silent_p.I121I|PTK7_ENST00000481273.1_Silent_p.I129I	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	121					actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CCTTCAACATCAAATGTGAGA	0.602000													7	29					0	0	1	0	0
FAM183B	340286	broad.mit.edu	37	7	38725414	38725414	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr7:38725414G>A	ENST00000409072.3	-	2	1126	c.192C>T	c.(190-192)gaC>gaT	p.D64D						family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						GAAACCTGGCGTCTGCGGGTT	0.532000													27	50					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121646627	121646627	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:121646627G>A	ENST00000489711.1	+	14	1535	c.1147G>A	c.(1147-1149)Ggt>Agt	p.G383S	SLC15A2_ENST00000295605.2_Missense_Mutation_p.G352S	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	383					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AATGGCTGTTGGTATGATCCT	0.383000													11	26					0	0	1	0	0
FZD6	8323	broad.mit.edu	37	8	104337688	104337688	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:104337688G>C	ENST00000358755.4	+	4	1671	c.1354G>C	c.(1354-1356)Gat>Cat	p.D452H	FZD6_ENST00000522566.1_Missense_Mutation_p.D452H|FZD6_ENST00000540287.1_Missense_Mutation_p.D147H|FZD6_ENST00000523739.1_Missense_Mutation_p.D420H	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	452					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			TTGGGTCTCTGATCATTGTCG	0.398000													32	169					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15437537	15437537	+	Missense_Mutation	SNP	G	G	A	rs137951137	byFrequency	TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr4:15437537G>A	ENST00000295297.4	+	2	450	c.191G>A	c.(190-192)cGc>cAc	p.R64H	C1QTNF7_ENST00000444304.2_Missense_Mutation_p.R57H|C1QTNF7_ENST00000429690.1_Missense_Mutation_p.R57H	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	57	Collagen-like.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						CCCCATGGTCGCATCGGCCTT	0.542000													14	30					0	0	1	0	0
ARL5A	26225	broad.mit.edu	37	2	152670738	152670738	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:152670738A>G	ENST00000295087.8	-	3	511	c.200T>C	c.(199-201)aTt>aCt	p.I67T	ARL5A_ENST00000428992.2_Missense_Mutation_p.I30T	NM_001037174.1|NM_012097.3	NP_001032251.1|NP_036229.1	Q9Y689	ARL5A_HUMAN	ADP-ribosylation factor-like 5A	67					small GTPase mediated signal transduction	intracellular	GTP binding			breast(1)|large_intestine(2)|liver(1)|lung(2)	6				BRCA - Breast invasive adenocarcinoma(221;0.153)		TTGGCCACCAATATCCCACAT	0.338000													23	72					0	0	1	0	0
SMC5	23137	broad.mit.edu	37	9	72913017	72913017	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:72913017C>G	ENST00000361138.5	+	9	1247	c.1189C>G	c.(1189-1191)Cag>Gag	p.Q397E		NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	397					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						CGAGAATCTTCAGCCCCAGAT	0.413000													19	88					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102074444	102074444	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:102074444G>A	ENST00000369138.1	+	3	963	c.473G>A	c.(472-474)cGt>cAt	p.R158H	GRIK2_ENST00000318991.6_Missense_Mutation_p.R158H|GRIK2_ENST00000369137.3_Missense_Mutation_p.R158H|GRIK2_ENST00000413795.1_Missense_Mutation_p.R158H|GRIK2_ENST00000358361.3_Missense_Mutation_p.R158H|GRIK2_ENST00000421544.1_Missense_Mutation_p.R158H|GRIK2_ENST00000369134.4_Missense_Mutation_p.R109H	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	158					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.R158H(2)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TCACTCAGCCGTGCCATTTTA	0.473000													11	41					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298868	125298868	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chrX:125298868C>G	ENST00000538699.1	-	2	1120	c.1040G>C	c.(1039-1041)cGa>cCa	p.R347P	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.R347P	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	347										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						GCCACCCTCTCGAGAGCACAG	0.622000													23	25					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71491598	71491598	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:71491598G>T	ENST00000265382.3	+	6	511	c.206G>T	c.(205-207)gGg>gTg	p.G69V	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.G69V	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	69	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		TTCAGCGAAGGGAGCAATCTG	0.398000													20	48					8.28177e-16	9.20197e-16	1	1	0
SRSF12	135295	broad.mit.edu	37	6	89808522	89808522	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:89808522C>G	ENST00000452027.2	-	5	754	c.561G>C	c.(559-561)aaG>aaC	p.K187N		NM_080743.4	NP_542781.3	Q8WXF0	SRS12_HUMAN	serine/arginine-rich splicing factor 12	187	Arg/Ser-rich (RS domain).				assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)	8						ACTTGGACCTCTTTTGTAAGG	0.438000													56	177					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6225053	6225053	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:6225053C>A	ENST00000264870.3	-	7	1104	c.839G>T	c.(838-840)tGg>tTg	p.W280L		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	280					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GATATTGTCCCAGGATCCAAC	0.498000													19	51					1.15919e-05	1.22665e-05	1	1	0
ZNF142	7701	broad.mit.edu	37	2	219520929	219520929	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:219520929A>T	ENST00000411696.2	-	3	1003	c.224T>A	c.(223-225)aTc>aAc	p.I75N	ZNF142_ENST00000449707.1_Missense_Mutation_p.I75N			P52746	ZN142_HUMAN	zinc finger protein 142	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CTCCACAATGATCTCCATGTT	0.592000													8	42					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139788219	139788219	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:139788219C>T	ENST00000303045.6	-	16	2239	c.1793G>A	c.(1792-1794)cGa>cAa	p.R598Q	COL22A1_ENST00000435777.1_Missense_Mutation_p.R598Q	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	598	Collagen-like 3.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTTCTCCTCGAGTTCCCTT	0.493000										HNSCC(7;0.00092)			19	73					0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4950635	4950635	+	RNA	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:4950635C>G	ENST00000592666.1	+	0	2106							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CGCTGGCTCTCAACTGCTTTG	0.607000													15	22					0	0	1	0	0
FARS2	10667	broad.mit.edu	37	6	5771587	5771587	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:5771587G>C	ENST00000324331.6	+	7	1617	c.1281G>C	c.(1279-1281)caG>caC	p.Q427H	FARS2_ENST00000274680.4_Missense_Mutation_p.Q427H			O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2, mitochondrial	427	FDX-ACB.				phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)|stomach(2)	15	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	CTCTGTCCCAGAGAGAGGTCA	0.592000													12	28					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30365422	30365422	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr20:30365422G>T	ENST00000340513.4	+	9	1391	c.863G>T	c.(862-864)cGa>cTa	p.R288L	TPX2_ENST00000300403.6_Missense_Mutation_p.R288L			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	288					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			TCTGAACTACGAAAGCATCCT	0.373000													20	42					2.32416e-17	2.59682e-17	1	1	0
VPS13B	157680	broad.mit.edu	37	8	100127959	100127959	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:100127959C>G	ENST00000395996.1	+	7	905	c.794C>G	c.(793-795)tCt>tGt	p.S265C	VPS13B_ENST00000355155.1_Missense_Mutation_p.S265C|VPS13B_ENST00000441350.2_Missense_Mutation_p.S265C|VPS13B_ENST00000358544.2_Missense_Mutation_p.S265C|VPS13B_ENST00000357162.2_Missense_Mutation_p.S265C			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	265					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTGAAACTTTCTATCACAGAT	0.303000													15	70					0	0	1	0	0
FUCA2	2519	broad.mit.edu	37	6	143816918	143816918	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:143816918C>A	ENST00000002165.5	-	7	1385	c.1330G>T	c.(1330-1332)Gaa>Taa	p.E444*	RP1-20N2.6_ENST00000589563.1_RNA|RP1-20N2.6_ENST00000591892.1_RNA	NM_032020.4	NP_114409.2	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma	444					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		TGTGGCAGTTCTACCATAATG	0.453000													12	30					5.50884e-06	5.86046e-06	1	1	0
MPDZ	8777	broad.mit.edu	37	9	13121779	13121779	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:13121779C>G	ENST00000319217.7	-	38	5437	c.5190G>C	c.(5188-5190)aaG>aaC	p.K1730N	MPDZ_ENST00000536827.1_Missense_Mutation_p.K1697N|MPDZ_ENST00000541718.1_Missense_Mutation_p.K1730N|MPDZ_ENST00000381022.2_Missense_Mutation_p.K1730N|MPDZ_ENST00000538841.1_Missense_Mutation_p.K589N|MPDZ_ENST00000546205.1_Missense_Mutation_p.K1744N|MPDZ_ENST00000381015.4_Missense_Mutation_p.K1730N|MPDZ_ENST00000447879.1_Missense_Mutation_p.K1697N|MPDZ_ENST00000541093.1_5'UTR	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1730	PDZ 11.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		TTCCCGGCTTCTTCTGCAGCT	0.478000													11	52					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53569561	53569561	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:53569561G>A	ENST00000025008.5	-	15	3351	c.2828C>T	c.(2827-2829)tCt>tTt	p.S943F	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000539297.1_Missense_Mutation_p.S943F|RB1CC1_ENST00000435644.2_Missense_Mutation_p.S943F	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	943					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ACAATTTTGAGAGTGCATTAT	0.323000													11	41					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28884863	28884863	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:28884863G>C	ENST00000322610.8	+	11	2432	c.1993G>C	c.(1993-1995)Gaa>Caa	p.E665Q	SH2B1_ENST00000545570.1_3'UTR|SH2B1_ENST00000337120.5_3'UTR|SH2B1_ENST00000538342.1_3'UTR|SH2B1_ENST00000359285.5_3'UTR|SH2B1_ENST00000563674.1_3'UTR|SH2B1_ENST00000395532.4_3'UTR			Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	665					blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						GAGGGCGCCAGAAGTGGCGGC	0.657000													4	19					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145529194	145529194	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr5:145529194C>G	ENST00000394434.2	-	15	1660	c.1494G>C	c.(1492-1494)atG>atC	p.M498I	LARS_ENST00000510191.1_Missense_Mutation_p.M444I|LARS_ENST00000545646.1_Missense_Mutation_p.M452I|LARS_ENST00000274562.9_Missense_Mutation_p.M471I	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	498	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGCGTCAATCATCTTTTTCT	0.383000													16	72					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7172550	7172550	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:7172550G>T	ENST00000406697.1	+	9	1292	c.664G>T	c.(664-666)Gat>Tat	p.D222Y	C1S_ENST00000360817.5_Missense_Mutation_p.D222Y|C1S_ENST00000328916.3_Missense_Mutation_p.D222Y|C1S_ENST00000402681.3_Missense_Mutation_p.D55Y			P09871	C1S_HUMAN	complement component 1, s subcomponent	222	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GCGGAGAGAAGATTTTGATGT	0.468000													12	36					0.00136819	0.00141051	1	1	0
GPR149	344758	broad.mit.edu	37	3	154055808	154055808	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:154055808C>G	ENST00000389740.2	-	4	1975	c.1876G>C	c.(1876-1878)Gat>Cat	p.D626H		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	626						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCTTCATTATCACAAATTTCA	0.423000													21	81					0	0	1	0	0
TRIM14	9830	broad.mit.edu	37	9	100857233	100857233	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:100857233C>T	ENST00000341469.2	-	4	625	c.616G>A	c.(616-618)Gag>Aag	p.E206K	TRIM14_ENST00000342043.3_Missense_Mutation_p.E206K|TRIM14_ENST00000375098.3_Missense_Mutation_p.E206K	NM_014788.2	NP_055603.2	Q14142	TRI14_HUMAN	tripartite motif containing 14	206						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(62;0.0559)				TTGACGGGCTCAAAGGAGAGG	0.587000													42	47					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52370181	52370181	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:52370181C>T	ENST00000356297.4	-	9	959	c.859G>A	c.(859-861)Gat>Aat	p.D287N	PXDNL_ENST00000543296.1_Missense_Mutation_p.D287N	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	287	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGTGTGCCATCATCAAACACA	0.413000													23	71					0	0	1	0	0
CDCA5	113130	broad.mit.edu	37	11	64851407	64851407	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:64851407G>C	ENST00000275517.3	-	1	216	c.44C>G	c.(43-45)tCc>tGc	p.S15C	CDCA5_ENST00000404147.3_Missense_Mutation_p.S15C	NM_080668.3	NP_542399.1	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	15					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding			large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CCGCTCACCGGAGCGCTGAGC	0.726000													10	33					0	0	1	0	0
CDKN3	1033	broad.mit.edu	37	14	54868293	54868293	+	Silent	SNP	T	T	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr14:54868293T>A	ENST00000541304.1	+	3	184	c.144T>A	c.(142-144)ctT>ctA	p.L48L	CDKN3_ENST00000442975.2_Intron|CDKN3_ENST00000556102.2_Silent_p.L48L|CDKN3_ENST00000556305.1_3'UTR|CDKN3_ENST00000458126.2_Silent_p.L48L|CDKN3_ENST00000335183.6_Silent_p.L48L|CDKN3_ENST00000543789.2_Silent_p.L48L			Q16667	CDKN3_HUMAN	cyclin-dependent kinase inhibitor 3	48					cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(2)|stomach(1)	3						TATGTGCTCTTCCAGGTGGGT	0.328000													15	45					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233710512	233710512	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:233710512C>T	ENST00000373566.3	+	27	3639	c.3442C>T	c.(3442-3444)Cag>Tag	p.Q1148*	GIGYF2_ENST00000373563.4_Nonsense_Mutation_p.Q1126*|GIGYF2_ENST00000409480.1_Nonsense_Mutation_p.Q1148*|GIGYF2_ENST00000409547.1_Nonsense_Mutation_p.Q1126*|GIGYF2_ENST00000409451.3_Nonsense_Mutation_p.Q1147*|GIGYF2_ENST00000409196.3_Nonsense_Mutation_p.Q1120*			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1126					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GAAGCTCTTTCAGGGAGTAAA	0.393000													20	40					0	0	1	0	0
TAS2R31	259290	broad.mit.edu	37	12	11183603	11183603	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:11183603G>A	ENST00000390675.2	-	1	403	c.332C>T	c.(331-333)gCc>gTc	p.A111V	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176885.2	NP_795366.2	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	111					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|lung(6)	7						GGAGAAATTGGCAATCTTGAG	0.403000													9	120					0	0	1	0	0
CHAC1	79094	broad.mit.edu	37	15	41246009	41246009	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr15:41246009G>A	ENST00000446533.3	+	1	663	c.354G>A	c.(352-354)aaG>aaA	p.K118K	CHAC1_ENST00000444189.2_Silent_p.K118K	NM_001142776.1|NM_024111.3	NP_001136248.1|NP_077016.2	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator homolog 1 (E. coli)	118					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCAGCGACAAGATGGTGAGCA	0.662000													4	8					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72008698	72008698	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:72008698G>T	ENST00000378743.3	-	29	5634	c.5276C>A	c.(5275-5277)tCa>tAa	p.S1759*		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1759					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TTTAATACTTGATTGAAGAGG	0.348000													23	55					6.44725e-10	6.97e-10	1	1	0
AMER2	219287	broad.mit.edu	37	13	25744032	25744032	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr13:25744032C>T	ENST00000357816.2	-	3	1844	c.1369G>A	c.(1369-1371)Gag>Aag	p.E457K	AMER2_ENST00000381853.3_Missense_Mutation_p.E457K|AMER2_ENST00000515384.1_Missense_Mutation_p.E576K					APC membrane recruitment protein 2																		GACGTCTCCTCGTTGTCCTTC	0.607000													23	53					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737341	62737341	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr20:62737341C>T	ENST00000369768.1	-	1	1183	c.844G>A	c.(844-846)Gtg>Atg	p.V282M		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	282						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					GTCAGGGCCACGACAGAGGCC	0.642000													13	26					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49690575	49690575	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:49690575G>A	ENST00000296452.4	+	5	3700	c.3586G>A	c.(3586-3588)Gag>Aag	p.E1196K		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1196					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCGCAAAGCTGAGCTGCTCCA	0.677000													10	11					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10570275	10570275	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:10570275G>A	ENST00000380702.2	+	11	1139	c.1139G>A	c.(1138-1140)cGg>cAg	p.R380Q	PDE4A_ENST00000440014.2_Missense_Mutation_p.R341Q|PDE4A_ENST00000352831.6_Missense_Mutation_p.R402Q|PDE4A_ENST00000592685.1_Missense_Mutation_p.R380Q|PDE4A_ENST00000293683.5_Missense_Mutation_p.R376Q|PDE4A_ENST00000344979.3_Missense_Mutation_p.R163Q			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	402	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	TCTCAGGAGCGGGACCTGCTG	0.637000													10	28					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52841200	52841200	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:52841200G>A	ENST00000371568.3	-	15	2423	c.2205C>T	c.(2203-2205)ttC>ttT	p.F735F	ORC1_ENST00000371566.1_Silent_p.F735F	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	735	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TCTGCTGGGAGAACTCACAGA	0.522000													15	51					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35092632	35092632	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:35092632C>G	ENST00000378617.3	-	7	1646	c.1252G>C	c.(1252-1254)Gag>Cag	p.E418Q	PIGO_ENST00000361778.2_Missense_Mutation_p.E418Q|PIGO_ENST00000341666.3_Missense_Mutation_p.E418Q|PIGO_ENST00000298004.5_Missense_Mutation_p.E418Q	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	418					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGTGTCGCCTCAGCCCCCTTG	0.587000													21	63					0	0	1	0	0
ABHD8	79575	broad.mit.edu	37	19	17405231	17405231	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:17405231G>A	ENST00000247706.3	-	4	1254	c.1015C>T	c.(1015-1017)Cgg>Tgg	p.R339W	MRPL34_ENST00000595444.1_Intron|MRPL34_ENST00000600434.1_Intron	NM_024527.4	NP_078803.4	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	339							hydrolase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	9						ATCATGGCCCGGAGTACGAAG	0.627000													35	90					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227963502	227963502	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:227963502T>C	ENST00000396625.3	-	19	1319	c.1112A>G	c.(1111-1113)gAc>gGc	p.D371G	COL4A4_ENST00000329662.7_Missense_Mutation_p.D371G	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	371	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GAACCCTGGGTCCCCTGGTGG	0.493000													6	28					0	0	1	0	0
CCNL2	81669	broad.mit.edu	37	1	1334480	1334480	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:1334480G>A	ENST00000400809.3	-	1	212	c.207C>T	c.(205-207)ctC>ctT	p.L69L	CCNL2_ENST00000408918.4_Silent_p.L69L	NM_030937.4	NP_112199.2	Q96S94	CCNL2_HUMAN	cyclin L2	69					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		TGTCGGTGTCGAGGCCGCTCG	0.677000													10	28					0	0	1	0	0
QDPR	5860	broad.mit.edu	37	4	17493925	17493925	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr4:17493925G>C	ENST00000281243.5	-	5	654	c.475C>G	c.(475-477)Cag>Gag	p.Q159E	QDPR_ENST00000508623.1_Intron|QDPR_ENST00000513615.1_Intron|QDPR_ENST00000428702.2_Missense_Mutation_p.Q128E	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase	159					dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	TGGCAGAGCTGGTGAACAGCA	0.647000													7	13					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118357632	118357632	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:118357632G>C	ENST00000528052.1	+	8	839	c.768G>C	c.(766-768)aaG>aaC	p.K256N	PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.K256N|PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.K256N			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	256					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CGGGATGCAAGAAGAATGCCC	0.517000													7	23					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102492935	102492935	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr14:102492935G>C	ENST00000360184.4	+	44	8826	c.8662G>C	c.(8662-8664)Gag>Cag	p.E2888Q		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2888					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						AGACCAAGAAGAGTTAAGAGA	0.368000													19	40					0	0	1	0	0
ZFP41	286128	broad.mit.edu	37	8	144332588	144332588	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:144332588G>A	ENST00000330701.4	+	2	944	c.575G>A	c.(574-576)cGc>cAc	p.R192H	ZFP41_ENST00000522452.1_Missense_Mutation_p.R192H|ZFP41_ENST00000520584.1_Missense_Mutation_p.R192H	NM_173832.3	NP_776193.1	Q8N8Y5	ZFP41_HUMAN	ZFP41 zinc finger protein	192					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|lung(4)|ovary(1)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CATCAGAAACGCCACCCTCGG	0.647000													40	114					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32134255	32134255	+	Silent	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:32134255A>G	ENST00000312561.4	+	4	780	c.366A>G	c.(364-366)tcA>tcG	p.S122S	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		GGTTGAACTCACCAATGAGGA	0.408000													17	47					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110492172	110492172	+	Silent	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chrX:110492172C>T	ENST00000324068.1	-	9	1439	c.1272G>A	c.(1270-1272)gaG>gaA	p.E424E	CAPN6_ENST00000541758.1_Silent_p.E169E	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	424	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						CCTTGAAGAGCTCAAAGCCAA	0.463000													29	41					0	0	1	0	0
LRRC39	127495	broad.mit.edu	37	1	100634004	100634004	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:100634004C>A	ENST00000370138.1	-	3	267	c.69G>T	c.(67-69)aaG>aaT	p.K23N	LRRC39_ENST00000370137.1_Missense_Mutation_p.K23N|LRRC39_ENST00000342895.3_Missense_Mutation_p.K23N	NM_001256385.1	NP_001243314.1	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	23										endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	13		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CATTGAGTTTCTTTATTCTTT	0.338000													10	32					0.000673444	0.000697869	1	1	0
CTSS	1520	broad.mit.edu	37	1	150722538	150722538	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:150722538C>A	ENST00000368985.3	-	6	997	c.737G>T	c.(736-738)gGc>gTc	p.G246V	CTSS_ENST00000480760.1_Intron|CTSS_ENST00000448301.2_Missense_Mutation_p.G196V	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	246					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			AGACACTGGGCCTTTATTGGC	0.378000													25	34					4.47668e-21	5.02998e-21	1	1	0
SPATA16	83893	broad.mit.edu	37	3	172631518	172631518	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:172631518G>T	ENST00000351008.3	-	10	1703	c.1520C>A	c.(1519-1521)gCa>gAa	p.A507E		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	507					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CATAGCATCTGCCATTAGTGA	0.348000													5	14					0.184627	0.186492	1	1	0
TDRD5	163589	broad.mit.edu	37	1	179620113	179620113	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:179620113G>C	ENST00000444136.1	+	12	2162	c.1912G>C	c.(1912-1914)Gac>Cac	p.D638H	TDRD5_ENST00000294848.8_Missense_Mutation_p.D638H|TDRD5_ENST00000367614.1_Missense_Mutation_p.D638H	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	638					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TTTTTTGTGTGACACATCCTC	0.413000													27	113					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15983977	15983977	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:15983977G>A	ENST00000268712.3	-	24	3499	c.3242C>T	c.(3241-3243)cCg>cTg	p.P1081L	NCOR1_ENST00000395851.1_Missense_Mutation_p.P1097L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1081	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding	p.P1081L(1)|p.P1081Q(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TCCCACTGACGGCTTGGGTGT	0.403000													15	50					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54691100	54691100	+	Silent	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:54691100C>A	ENST00000245615.1	-	4	756	c.276G>T	c.(274-276)ctG>ctT	p.L92L	MBOAT7_ENST00000391754.1_Silent_p.L92L|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000338624.6_Intron|MBOAT7_ENST00000431666.2_Intron	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	92					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGGGCAGGCCCAGGAGGCTGA	0.652000													3	5					0.004672	0.00479179	1	1	0
AKR7L	246181	broad.mit.edu	37	1	19596156	19596156	+	RNA	SNP	G	G	T	rs6665756	by1000genomes	TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:19596156G>T	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						CCTGCCGGGTGGTGGCGCTGT	0.562000													4	54					0.00909568	0.00923419	1	1	0
GML	2765	broad.mit.edu	37	8	143921918	143921918	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:143921918G>A	ENST00000220940.1	+	2	155	c.65G>A	c.(64-66)cGc>cAc	p.R22H		NM_002066.2	NP_002057.1	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule like	22					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				NS(1)|central_nervous_system(2)|endometrium(1)|large_intestine(6)|lung(8)	18	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCCACCATGCGCGCTCAGTGT	0.577000													34	51					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35042305	35042305	+	Silent	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:35042305C>G	ENST00000312292.5	+	1	101	c.54C>G	c.(52-54)ctC>ctG	p.L18L	C9orf131_ENST00000421362.2_Intron|C9orf131_ENST00000354479.5_Intron	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	18										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TGGGGCTTCTCTGGGGCCAAC	0.552000													5	42					0	0	1	0	0
UGT1A4	54657	broad.mit.edu	37	2	234628224	234628224	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:234628224C>G	ENST00000373409.3	+	1	801	c.758C>G	c.(757-759)tCc>tGc	p.S253C	UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A5_ENST00000373414.3_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		AGCTATGCATCCGTGTGGCTG	0.522000													44	148					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40742709	40742709	+	Silent	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr22:40742709C>G	ENST00000216194.7	+	1	203	c.147C>G	c.(145-147)gcC>gcG	p.A49A	ADSL_ENST00000342312.6_Silent_p.A49A|ADSL_ENST00000454266.2_Silent_p.A49A	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	49					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						TGGCGGAGGCCGAGCAGGTAA	0.687000													4	8					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49697990	49697990	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:49697990G>A	ENST00000296452.4	+	6	8826	c.8712G>A	c.(8710-8712)gaG>gaA	p.E2904E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2904					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTCCAGAGGAGGCTCACCTTC	0.677000													22	44					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7915473	7915473	+	Silent	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:7915473C>G	ENST00000254854.4	+	9	1911	c.1761C>G	c.(1759-1761)ctC>ctG	p.L587L		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	587	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TCCAGGAGCTCCGGCATGAGA	0.592000													10	35					0	0	1	0	0
ZNF641	121274	broad.mit.edu	37	12	48741052	48741052	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:48741052G>C	ENST00000544117.2	-	3	1009	c.301C>G	c.(301-303)Ctt>Gtt	p.L101V	ZNF641_ENST00000301042.3_Missense_Mutation_p.L101V|ZNF641_ENST00000547026.1_Missense_Mutation_p.L87V|ZNF641_ENST00000448928.3_Missense_Mutation_p.L87V			Q96N77	ZN641_HUMAN	zinc finger protein 641	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	12						CCAGCCGCAAGAAGTGCAGCT	0.537000													4	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9011002	9011002	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:9011002G>C	ENST00000397910.4	-	37	39119	c.38916C>G	c.(38914-38916)ttC>ttG	p.F12972L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12974					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCGATGGGTGAAACCTGCAT	0.542000													17	78					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117681103	117681103	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:117681103G>C	ENST00000368508.3	-	23	3715	c.3517C>G	c.(3517-3519)Caa>Gaa	p.Q1173E	ROS1_ENST00000368507.3_Missense_Mutation_p.Q1168E|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1173					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CACACAACTTGATTTTGATCC	0.363000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								13	54					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380277	78380277	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:78380277A>T	ENST00000278550.7	-	32	7575	c.7113T>A	c.(7111-7113)agT>agA	p.S2371R		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AACCTGTTCCACTAAAGACAG	0.473000													14	124					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	41					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10102535	10102535	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chrX:10102535C>T	ENST00000380861.4	+	19	3053	c.2662C>T	c.(2662-2664)Cgg>Tgg	p.R888W	WWC3_ENST00000454666.1_Missense_Mutation_p.R888W	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	888										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CGTGAAGGAGCGGCCCAGCCG	0.557000													49	51					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74154560	74154560	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:74154560C>T	ENST00000269391.6	-	13	1459	c.1327G>A	c.(1327-1329)Gtg>Atg	p.V443M	RNF157_ENST00000319945.6_Missense_Mutation_p.V443M	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	443	Ser-rich.						zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			TCATGCAGCACGGAAGAGTTT	0.502000													23	61					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123109097	123109097	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr4:123109097C>G	ENST00000264501.4	+	9	1048	c.675C>G	c.(673-675)atC>atG	p.I225M	KIAA1109_ENST00000455637.1_Missense_Mutation_p.I225M|KIAA1109_ENST00000388738.3_Missense_Mutation_p.I225M			Q2LD37	K1109_HUMAN	KIAA1109	225					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CTCTGTGCATCAACTTTGATG	0.358000													12	33					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173526596	173526596	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:173526596T>A	ENST00000367714.3	-	10	1520	c.1098A>T	c.(1096-1098)gaA>gaT	p.E366D	SLC9C2_ENST00000536496.1_Missense_Mutation_p.E264D|SLC9C2_ENST00000466087.1_5'UTR|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	366					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GCCAATTATATTCATAATTTG	0.348000													13	151					0	0	1	0	0
TNFSF11	8600	broad.mit.edu	37	13	43180865	43180865	+	Silent	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr13:43180865G>C	ENST00000398795.2	+	5	914	c.546G>C	c.(544-546)ctG>ctC	p.L182L	TNFSF11_ENST00000405262.2_Silent_p.L182L|TNFSF11_ENST00000358545.2_Silent_p.L182L|TNFSF11_ENST00000544862.1_Silent_p.L182L|TNFSF11_ENST00000239849.6_Silent_p.L255L	NM_003701.3	NP_003692.1	O14788	TNF11_HUMAN	tumor necrosis factor (ligand) superfamily, member 11	255					immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding			kidney(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	10		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		CTCATACCCTGATGAAAGGAG	0.398000													31	55					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78319633	78319633	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:78319633G>C	ENST00000582970.1	+	29	7641	c.7498G>C	c.(7498-7500)Gaa>Caa	p.E2500Q	RNF213_ENST00000336301.6_Missense_Mutation_p.E573Q|RNF213_ENST00000508628.2_Missense_Mutation_p.E2549Q	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTGTATCAAAGAAGTCCTGTG	0.483000													24	71					0	0	1	0	0
SPTLC1	10558	broad.mit.edu	37	9	94830314	94830314	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:94830314G>C	ENST00000262554.2	-	6	499	c.494C>G	c.(493-495)tCa>tGa	p.S165*	SPTLC1_ENST00000482632.1_5'UTR	NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	165						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AAATCCATATGAGTATATAAT	0.348000													10	60					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137497527	137497527	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr5:137497527A>C	ENST00000254900.5	-	17	2578	c.2207T>G	c.(2206-2208)gTt>gGt	p.V736G	BRD8_ENST00000411594.2_Missense_Mutation_p.V739G|BRD8_ENST00000402931.1_Missense_Mutation_p.V736G|BRD8_ENST00000230901.5_Missense_Mutation_p.V809G|BRD8_ENST00000515014.1_5'UTR|BRD8_ENST00000455658.2_Missense_Mutation_p.V695G	NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	736	Bromo 1.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GTCATCTGTAACAGGCTGCAG	0.458000													8	36					0	0	1	0	0
CA3	761	broad.mit.edu	37	8	86352120	86352120	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:86352120G>C	ENST00000285381.2	+	2	297	c.214G>C	c.(214-216)Gat>Cat	p.D72H		NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	72					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						TGTATTTGATGATACTTATGA	0.428000													10	46					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233993	43233993	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:43233993G>C	ENST00000327495.5	-	4	1109	c.925C>G	c.(925-927)Caa>Gaa	p.Q309E	PSG3_ENST00000595140.1_Missense_Mutation_p.Q309E	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	309	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				ATTTCACATTGATAGGGTCCT	0.502000													38	129					0	0	1	0	0
C7orf25	79020	broad.mit.edu	37	7	42949829	42949829	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr7:42949829C>G	ENST00000350427.4	-	2	946	c.671G>C	c.(670-672)aGa>aCa	p.R224T	C7orf25_ENST00000431882.2_Missense_Mutation_p.R282T|PSMA2_ENST00000442788.1_3'UTR|C7orf25_ENST00000438029.1_Missense_Mutation_p.R224T|C7orf25_ENST00000447342.1_Missense_Mutation_p.R224T			Q9BPX7	CG025_HUMAN	chromosome 7 open reading frame 25	224										endometrium(6)|kidney(1)|large_intestine(7)|lung(2)|skin(1)	17						TCGGTCAACTCTGGTCACCTG	0.423000													27	52					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52797498	52797498	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:52797498C>T	ENST00000257974.2	-	2	684	c.607G>A	c.(607-609)Ggc>Agc	p.G203S		NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	203	Coil 1B.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		ttcttgtagccctccagtgcA	0.582000													27	101					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35398240	35398240	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:35398240G>A	ENST00000378495.3	+	30	3762	c.3540G>A	c.(3538-3540)ctG>ctA	p.L1180L	UNC13B_ENST00000396787.1_Silent_p.L1192L|UNC13B_ENST00000378496.4_Silent_p.L1180L|UNC13B_ENST00000481299.1_3'UTR	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1180					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TGCAGCAACTGAGGGTCCAGC	0.512000													9	22					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112021406	112021406	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:112021406C>T	ENST00000354650.3	-	9	1369	c.763G>A	c.(763-765)Gat>Aat	p.D255N	FYN_ENST00000229471.4_Intron|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000368682.3_Intron|FYN_ENST00000229470.5_Intron|FYN_ENST00000368678.4_Intron|FYN_ENST00000356013.2_Intron|FYN_ENST00000368667.2_Missense_Mutation_p.D255N|FYN_ENST00000538466.1_Intron	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	255					axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	ACAGACAGATCGGTAAGCCTT	0.542000													24	68					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115971687	115971687	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:115971687G>A	ENST00000251864.2	+	14	1876	c.1723G>A	c.(1723-1725)Gga>Aga	p.G575R	TDRD1_ENST00000369280.1_Missense_Mutation_p.G575R|TDRD1_ENST00000422662.1_Intron|TDRD1_ENST00000369282.1_Missense_Mutation_p.G575R|TDRD1_ENST00000369281.2_Intron	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	575	Tudor 2.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGTACTGGTCGGATATGTAGA	0.398000													26	69					0	0	1	0	0
MMP10	4319	broad.mit.edu	37	11	102647507	102647507	+	Splice_Site	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:102647507C>T	ENST00000279441.4	-	5	659	c.622_splice	c.e5-1	p.G208_splice		NM_002425.2	NP_002416.1	P09238	MMP10_HUMAN	matrix metallopeptidase 10 (stromelysin 2)	208					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(2)|lung(6)	22	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TAAATTGGTGCCTGTATGAAA	0.438000													18	385					0	0	1	0	0
TMED2	10959	broad.mit.edu	37	12	124069243	124069243	+	Silent	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:124069243C>G	ENST00000262225.3	+	1	166	c.60C>G	c.(58-60)ggC>ggG	p.G20G	RP11-486O12.2_ENST00000498967.2_lincRNA	NM_006815.3	NP_006806.1	Q15363	TMED2_HUMAN	transmembrane emp24 domain trafficking protein 2	20					protein transport|vesicle-mediated transport	COPI coated vesicle membrane|ER-Golgi intermediate compartment|integral to membrane|microsome|zymogen granule membrane	protein binding			kidney(1)|large_intestine(4)|lung(1)|prostate(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000138)|Epithelial(86;0.000613)|all cancers(50;0.00745)		CGGTCTCGGGCTATTTCGTTA	0.642000													6	27					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594814	64594814	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:64594814G>A	ENST00000342711.5	-	33	4206	c.4207C>T	c.(4207-4209)Cgc>Tgc	p.R1403C		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1403					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CTCTTGGTGCGGAACAGCTGG	0.652000													23	123					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1218423	1218423	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:1218423C>T	ENST00000326873.7	+	2	1471	c.298C>T	c.(298-300)Caa>Taa	p.Q100*	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	100	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(4)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGGAAATTCAACTACTGAG	0.527000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			20	51					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49316263	49316263	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:49316263G>C	ENST00000351842.4	-	20	2584	c.2576C>G	c.(2575-2577)tCt>tGt	p.S859C	USP4_ENST00000265560.4_Missense_Mutation_p.S906C	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	906					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CTGATCCTCAGAGGCCAGGGA	0.423000													36	50					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38679420	38679420	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr14:38679420G>A	ENST00000267377.2	+	3	1443	c.826G>A	c.(826-828)Gtg>Atg	p.V276M		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	276					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GGTGATGATGGTGGTGATGGT	0.572000													13	44					0	0	1	0	0
FICD	11153	broad.mit.edu	37	12	108912624	108912624	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:108912624G>A	ENST00000552695.1	+	3	984	c.749G>A	c.(748-750)cGc>cAc	p.R250H	FICD_ENST00000361549.2_3'UTR	NM_007076.2	NP_009007.2	Q9BVA6	FICD_HUMAN	FIC domain containing	250					negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity			NS(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|upper_aerodigestive_tract(2)	15						CTGGAGACCCGCTACGCCGTG	0.582000													14	37					0	0	1	0	0
SP2	6668	broad.mit.edu	37	17	45994113	45994113	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:45994113G>A	ENST00000376741.4	+	3	813	c.676G>A	c.(676-678)Ggg>Agg	p.G226R	AC003665.1_ENST00000451140.2_RNA|AC003665.1_ENST00000411573.2_RNA|AC003665.1_ENST00000433001.1_RNA|AC003665.1_ENST00000585280.1_RNA	NM_003110.5	NP_003101.3	Q02086	SP2_HUMAN	Sp2 transcription factor	226					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	13						CAGTGACACCGGGGCCCCTAC	0.612000													21	70					0	0	1	0	0
SPSB3	90864	broad.mit.edu	37	16	1828538	1828538	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:1828538C>T	ENST00000566339.1	-	3	532	c.202G>A	c.(202-204)Gag>Aag	p.E68K	SPSB3_ENST00000301717.4_Missense_Mutation_p.E68K	NM_080861.3	NP_543137.2	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box containing 3	68					intracellular signal transduction					endometrium(1)|kidney(4)|lung(3)|prostate(2)	10						CAGAAGGACTCGCCGGTCACG	0.677000													18	46					0	0	1	0	0
TMCO2	127391	broad.mit.edu	37	1	40717103	40717103	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:40717103T>C	ENST00000372766.3	+	2	479	c.386T>C	c.(385-387)aTt>aCt	p.I129T	TMCO2_ENST00000468258.1_3'UTR	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	129						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CAAGAGAAAATTTTGAAAAAA	0.413000													11	49					0	0	1	0	0
MORN3	283385	broad.mit.edu	37	12	122097169	122097169	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:122097169G>A	ENST00000355329.3	-	2	401	c.231C>T	c.(229-231)ctC>ctT	p.L77L		NM_173855.4	NP_776254.3	Q6PF18	MORN3_HUMAN	MORN repeat containing 3	77										breast(2)|large_intestine(1)|lung(4)|skin(1)|stomach(1)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)		CAGGAAGGCTGAGGGTGCCGT	0.557000													21	43					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578524	7578524	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:7578524G>C	ENST00000420246.2	-	5	538	c.406C>G	c.(406-408)Caa>Gaa	p.Q136E	TP53_ENST00000445888.2_Missense_Mutation_p.Q136E|TP53_ENST00000359597.4_Missense_Mutation_p.Q136E|TP53_ENST00000455263.2_Missense_Mutation_p.Q136E|TP53_ENST00000269305.4_Missense_Mutation_p.Q136E|TP53_ENST00000413465.2_Missense_Mutation_p.Q136E	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	136	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> E (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(34)|p.0?(8)|p.C135fs*9(3)|p.Q136E(3)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.Q136K(1)|p.S127_Q136del10(1)|p.V73fs*9(1)|p.Q43*(1)|p.Y126fs*11(1)|p.Q4*(1)|p.C3fs*9(1)|p.C42fs*9(1)|p.C135_A138delCQLA(1)|p.Q136_K139delQLAK(1)|p.Q136fs*34(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	43					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53854798	53854798	+	Splice_Site	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:53854798G>A	ENST00000603815.1	+	7	725		c.e7-1		RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000447282.1_Splice_Site|PCBP2_ENST00000359282.5_Splice_Site|PCBP2_ENST00000437231.1_Splice_Site|PCBP2_ENST00000552819.1_Splice_Site|PCBP2_ENST00000439930.3_Splice_Site|PCBP2_ENST00000359462.5_Splice_Site|PCBP2_ENST00000455667.3_Splice_Site|PCBP2_ENST00000541275.1_Splice_Site|PCBP2_ENST00000549863.1_Splice_Site|PCBP2_ENST00000548933.1_Splice_Site|PCBP2_ENST00000552296.2_Splice_Site|PCBP2_ENST00000546463.1_Splice_Site	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2						innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TTACTCCAAAGAGTACAGGGG	0.438000													16	40					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102988494	102988494	+	Silent	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr11:102988494C>T	ENST00000375735.2	+	6	1045	c.901C>T	c.(901-903)Cta>Tta	p.L301L	DYNC2H1_ENST00000334267.7_Silent_p.L301L|DYNC2H1_ENST00000398093.3_Silent_p.L301L	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	301	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTGTAATCATCTAACAGGTCA	0.403000													14	272					0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64780062	64780062	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:64780062A>G	ENST00000422803.1	+	2	1768	c.1454A>G	c.(1453-1455)aAt>aGt	p.N485S	AFTPH_ENST00000409183.1_Missense_Mutation_p.N116S|AFTPH_ENST00000238856.4_Missense_Mutation_p.N485S|AFTPH_ENST00000409933.1_Missense_Mutation_p.N485S|AFTPH_ENST00000238855.7_Missense_Mutation_p.N485S|AFTPH_ENST00000487769.1_3'UTR			Q6ULP2	AFTIN_HUMAN	aftiphilin	485					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						GGGGATATAAATGCTGTTTCT	0.363000													34	74					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101075915	101075915	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr8:101075915G>A	ENST00000360863.6	-	8	1275	c.1081C>T	c.(1081-1083)Cat>Tat	p.H361Y	RGS22_ENST00000523437.1_Missense_Mutation_p.H349Y|RGS22_ENST00000523287.1_Missense_Mutation_p.H180Y	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	361					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTCTTGCCATGAATAGACTCA	0.343000													16	59					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51072582	51072582	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:51072582G>A	ENST00000301180.5	+	8	1071	c.1037G>A	c.(1036-1038)tGg>tAg	p.W346*		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	346						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CTGCAGCGCTGGGGTACCACT	0.532000													16	29					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726803	32726803	+	Missense_Mutation	SNP	C	C	T	rs114730424	by1000genomes	TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr6:32726803C>T	ENST00000435145.2	-	3	531	c.470G>A	c.(469-471)cGg>cAg	p.R157Q	HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.R157Q|HLA-DQB2_ENST00000411527.1_Missense_Mutation_p.R157Q			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	157					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CCGAAACCACCGGACTTTGAT	0.547000													8	100					0	0	1	0	0
ICA1L	130026	broad.mit.edu	37	2	203686198	203686198	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:203686198G>C	ENST00000392237.2	-	5	399	c.242C>G	c.(241-243)tCa>tGa	p.S81*	ICA1L_ENST00000418208.1_Intron|ICA1L_ENST00000425178.1_Nonsense_Mutation_p.S81*|ICA1L_ENST00000358299.2_Nonsense_Mutation_p.S81*	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	81	AH.									breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTCTTCCTCTGATATAACTAG	0.353000													15	27					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39650601	39650601	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr14:39650601G>C	ENST00000216832.4	+	9	1755	c.1688G>C	c.(1687-1689)aGa>aCa	p.R563T	PNN_ENST00000557680.1_Intron	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	563	Ser-rich.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		AGCAGAAGTAGAGGTCGAGCT	0.448000													12	51					0	0	1	0	0
MSL2	55167	broad.mit.edu	37	3	135871452	135871452	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr3:135871452C>G	ENST00000309993.2	-	2	1003	c.271G>C	c.(271-273)Gag>Cag	p.E91Q	MSL2_ENST00000434835.2_Missense_Mutation_p.E17Q	NM_018133.3	NP_060603.2	Q9HCI7	MSL2_HUMAN	male-specific lethal 2 homolog (Drosophila)	91					histone H4-K16 acetylation	MSL complex	zinc ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	18						TTGTTTTCCTCAAACTGCTCA	0.408000													37	110					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26851329	26851329	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:26851329G>C	ENST00000376236.4	+	14	1899	c.1444G>C	c.(1444-1446)Gag>Cag	p.E482Q	APBB1IP_ENST00000493857.1_3'UTR	NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	482					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGTTCTCCAAGAGGCCCAGAG	0.478000													35	105					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2815863	2815863	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr16:2815863G>C	ENST00000301740.8	+	11	5883	c.5334G>C	c.(5332-5334)agG>agC	p.R1778S		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1778	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CCCGCTCAAGGAGAGAGAAAA	0.582000													13	33					0	0	1	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783657	149783657	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:149783657G>A	ENST00000427880.2	-	1	268	c.222C>T	c.(220-222)atC>atT	p.I74I	HIST2H2BF_ENST00000369167.1_Silent_p.I74I|HIST2H2BF_ENST00000545683.1_Silent_p.I74I|HIST2H2BF_ENST00000469483.1_5'UTR			Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf	74					nucleosome assembly	nucleosome|nucleus	DNA binding	p.I74I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)					CCTCTCCCGCGATGCGCTCGA	0.642000													25	107					0	0	1	0	0
MCU	90550	broad.mit.edu	37	10	74631162	74631162	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:74631162G>C	ENST00000536019.1	+	6	983	c.538G>C	c.(538-540)Gag>Cag	p.E180Q	MCU_ENST00000357157.6_Missense_Mutation_p.E208Q|MCU_ENST00000373053.3_Missense_Mutation_p.E229Q|MCU_ENST00000605416.1_3'UTR	NM_001270680.1	NP_001257609.1	Q8NE86	MCU_HUMAN	mitochondrial calcium uniporter	229					elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	14						CAGAAAAGCTGAGAAGAGGAC	0.443000													35	125					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971153	21971153	+	Nonsense_Mutation	SNP	C	C	A	rs121913383		TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr9:21971153C>A	ENST00000304494.5	-	2	475	c.205G>T	c.(205-207)Gag>Tag	p.E69*	CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.E18*|CDKN2A_ENST00000530628.2_Missense_Mutation_p.G83V|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.E18*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.E69*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.G83V|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.E18*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.E18*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.G124V|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.E18*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.E69*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.E69*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	69			E -> G (found in some patients with melanoma; partial loss of CDK4 binding).|E -> K (in a bladder tumor).|E -> V (in a lung tumor).|Missing (in melanoma; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.E69*(16)|p.E61fs*49(2)|p.E61fs*50(1)|p.R122fs*49(1)|p.E69K(1)|p.E61_L94del(1)|p.0(1)|p.E69fs*77(1)|p.V59fs*45(1)|p.L65fs*38(1)|p.L65fs*77(1)|p.A68fs*3(1)|p.L63fs*75(1)|p.L64_E69>Q(1)|p.E69Q(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGTTGGGCTCCGCGCCGTGG	0.711000	E69*(A375_SKIN)|E69*(CAL27_UPPER_AERODIGESTIVE_TRACT)|E69*(NCIH1975_LUNG)|E69*(SUIT2_PANCREAS)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			5	6					0.000602214	0.000627307	1	1	0
CDH9	1007	broad.mit.edu	37	5	26903762	26903762	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr5:26903762A>T	ENST00000231021.4	-	6	1155	c.983T>A	c.(982-984)aTt>aAt	p.I328N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	328	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GACAGTTATAATCCCTTCCTG	0.403000													63	117					0	0	1	0	0
ABCB6	10058	broad.mit.edu	37	2	220078891	220078891	+	Silent	SNP	G	G	A	rs144749234		TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:220078891G>A	ENST00000265316.3	-	8	1720	c.1404C>T	c.(1402-1404)gcC>gcT	p.A468A	ABCB6_ENST00000439002.2_Silent_p.A422A	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	468	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGTAACTCTCGGCGTTGTAAT	0.488000													15	74					0	0	1	0	0
RPUSD2	27079	broad.mit.edu	37	15	40862066	40862066	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr15:40862066A>G	ENST00000315616.7	+	1	568	c.530A>G	c.(529-531)tAc>tGc	p.Y177C	RPUSD2_ENST00000559271.1_Intron	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	177					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		CCCCTGGCCTACTATGAGGCC	0.622000													4	6					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135890465	135890465	+	Splice_Site	SNP	T	T	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:135890465T>C	ENST00000264158.8	+	14	1280	c.1236_splice	c.e14-1	p.F413_splice	RAB3GAP1_ENST00000442034.1_Splice_Site_p.F413_splice|RAB3GAP1_ENST00000539493.1_Splice_Site_p.F369_splice|RAB3GAP1_ENST00000487003.1_3'UTR	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	413						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		TTCCTTCAAGTTCTTATTCCC	0.294000													10	26					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216272015	216272015	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:216272015C>T	ENST00000354785.4	-	18	2917	c.2548G>A	c.(2548-2550)Gaa>Aaa	p.E850K	FN1_ENST00000336916.4_Missense_Mutation_p.E850K|FN1_ENST00000323926.6_Missense_Mutation_p.E850K|FN1_ENST00000446046.1_Missense_Mutation_p.E850K|FN1_ENST00000432072.2_Missense_Mutation_p.E850K|FN1_ENST00000421182.1_Missense_Mutation_p.E850K|FN1_ENST00000443816.1_Missense_Mutation_p.E850K|FN1_ENST00000359671.1_Missense_Mutation_p.E850K|FN1_ENST00000357867.4_Missense_Mutation_p.E850K|FN1_ENST00000357009.2_Missense_Mutation_p.E850K|FN1_ENST00000356005.4_Missense_Mutation_p.E850K|FN1_ENST00000346544.3_Missense_Mutation_p.E850K|FN1_ENST00000345488.5_Missense_Mutation_p.E850K			P02751	FINC_HUMAN	fibronectin 1	850	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCTACCTTCTACTGATGGC	0.433000													22	60					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54691101	54691101	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:54691101A>G	ENST00000245615.1	-	4	755	c.275T>C	c.(274-276)cTg>cCg	p.L92P	MBOAT7_ENST00000391754.1_Missense_Mutation_p.L92P|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000338624.6_Intron|MBOAT7_ENST00000431666.2_Intron	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	92					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGGCAGGCCCAGGAGGCTGAG	0.652000													3	5					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106937877	106937877	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:106937877C>T	ENST00000369701.3	+	14	2182	c.1955C>T	c.(1954-1956)cCt>cTt	p.P652L	SORCS3_ENST00000369699.4_Intron	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	652						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACTTCGGTTCCTCTCTTTGTT	0.478000													10	38					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64067335	64067335	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr15:64067335C>A	ENST00000443617.2	-	2	575	c.488G>T	c.(487-489)cGa>cTa	p.R163L		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	163					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TAGACCAGTTCGAACACCCAT	0.468000													48	157					1.76056e-25	1.98933e-25	1	1	0
AATK	9625	broad.mit.edu	37	17	79098605	79098605	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:79098605C>T	ENST00000326724.4	-	9	908	c.884G>A	c.(883-885)cGc>cAc	p.R295H	AATK_ENST00000417379.1_Missense_Mutation_p.R192H	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	295	Protein kinase.					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CGCGATCCAGCGCAGAGGCAC	0.667000													7	14					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6438571	6438571	+	Silent	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:6438571G>C	ENST00000162749.2	-	10	1574	c.1275C>G	c.(1273-1275)ctC>ctG	p.L425L	TNFRSF1A_ENST00000540022.1_Silent_p.L382L	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	425	Death.				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						CCATGTCGCGGAGCACGCGTC	0.736000													6	5					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28672097	28672097	+	Missense_Mutation	SNP	C	C	G	rs140856220		TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr18:28672097C>G	ENST00000280904.6	-	3	764	c.321G>C	c.(319-321)aaG>aaC	p.K107N	DSC2_ENST00000251081.6_Missense_Mutation_p.K107N	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	107					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CAAATATTTTCTTCTTTTCTT	0.338000													7	44					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39003117	39003117	+	Missense_Mutation	SNP	G	G	A	rs150230127		TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr19:39003117G>A	ENST00000355481.4	+	63	9597	c.9466G>A	c.(9466-9468)Gtc>Atc	p.V3156I	RYR1_ENST00000359596.3_Missense_Mutation_p.V3156I|RYR1_ENST00000360985.3_Missense_Mutation_p.V3156I	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3156					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGGAGATGACGTCATCCGTAA	0.622000													22	41					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26091112	26091112	+	Silent	SNP	G	G	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:26091112G>A	ENST00000313735.6	-	21	2720	c.2487C>T	c.(2485-2487)acC>acT	p.T829T		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	829	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CCAGGAAGTAGGTGAGGGCCT	0.617000													3	19					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27538843	27538843	+	RNA	SNP	G	G	T			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr10:27538843G>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GTCTCAGCTGGGGCCTCCTGC	0.512000													40	80					2.32173e-10	2.52362e-10	1	1	0
COQ5	84274	broad.mit.edu	37	12	120941680	120941680	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:120941680G>C	ENST00000288532.6	-	7	931	c.891C>G	c.(889-891)ttC>ttG	p.F297L	COQ5_ENST00000445328.2_Missense_Mutation_p.F223L	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	297					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCATGTCCTTGAACTCTTCCT	0.413000													23	58					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922071	37922071	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:37922071C>G	ENST00000346872.3	-	8	1563	c.1502G>C	c.(1501-1503)aGa>aCa	p.R501T	IKZF3_ENST00000583368.1_Missense_Mutation_p.R254T|IKZF3_ENST00000535189.1_Missense_Mutation_p.R467T|IKZF3_ENST00000467757.1_Missense_Mutation_p.R445T|IKZF3_ENST00000439167.2_Missense_Mutation_p.R428T|IKZF3_ENST00000439016.2_Missense_Mutation_p.R406T|IKZF3_ENST00000394189.2_Missense_Mutation_p.R319T|IKZF3_ENST00000377944.3_Missense_Mutation_p.R358T|IKZF3_ENST00000377945.3_Missense_Mutation_p.R367T|IKZF3_ENST00000377952.2_Missense_Mutation_p.R280T|IKZF3_ENST00000377958.2_Missense_Mutation_p.R414T|IKZF3_ENST00000350532.3_Missense_Mutation_p.R462T|IKZF3_ENST00000346243.3_Missense_Mutation_p.R423T|IKZF3_ENST00000351680.3_Missense_Mutation_p.R462T	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	501					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GTGTTCTCCTCTGGCTATGTG	0.483000													19	83					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102296381	102296381	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr1:102296381delA	ENST00000370103.4	-	3	432	c.219delT	c.(217-219)gtfs	p.V73fs	OLFM3_ENST00000359814.3_Frame_Shift_Del_p.V93fs|OLFM3_ENST00000338858.5_Frame_Shift_Del_p.V93fs|OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000536598.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	93						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		ACATGTTCTGAACCTGTTGAA	0.343													17	65	---	---	---	---					
COL4A4	1286	broad.mit.edu	37	2	227895306	227895318	+	Splice_Site	DEL	CAGGTGCTCCTGA	CAGGTGCTCCTGA	-			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr2:227895306_227895318delCAGGTGCTCCTGA	ENST00000396625.3	-	41	4025_4033	c.3817_splice	c.e41-1	p.A1273_splice	COL4A4_ENST00000329662.7_Splice_Site_p.A1273_splice	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1273	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTGGAGGCCCAGGTGCTCCTGACCACAGAGAA	0.540													9	31	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187628651	187628652	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr4:187628651_187628652insA	ENST00000441802.2	-	2	2539_2540	c.2330_2331insT	c.(2329-2331)ttcfs	p.F777fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	777	Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAAGAGGAGATAAAATTTTCAG	0.436										HNSCC(5;0.00058)			31	72	---	---	---	---					
TENC1	23371	broad.mit.edu	37	12	53447799	53447802	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:53447799_53447802delGTAA	ENST00000314250.6	+	6	640		c.e6+1		RP11-983P16.4_ENST00000550601.1_RNA|TENC1_ENST00000552570.1_Splice_Site|RP11-983P16.4_ENST00000551890.1_RNA|RP11-983P16.4_ENST00000546793.1_RNA|TENC1_ENST00000546602.1_Splice_Site|TENC1_ENST00000451358.1_Splice_Site|TENC1_ENST00000379902.3_Splice_Site|TENC1_ENST00000549700.1_Splice_Site|TENC1_ENST00000314276.3_Splice_Site	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)						intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CTCTGCCCAGGTAAGTGAGGGTGC	0.627											OREG0021855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	31	---	---	---	---					
CDK4	1019	broad.mit.edu	37	12	58145293	58145294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr12:58145293_58145294insG	ENST00000257904.6	-	2	572_573	c.207_208insC	c.(205-210)ccatgtfs	p.C70fs	CDK4_ENST00000551888.1_5'UTR|CDK4_ENST00000549606.1_Intron|CDK4_ENST00000540325.1_5'UTR|CDK4_ENST00000312990.6_Frame_Shift_Ins_p.C70fs	NM_000075.3	NP_000066.1	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	70	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CGGACAACATTGGGATGCTCAA	0.564			Mis			melanoma			Hereditary Melanoma				26	69	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7572959	7572962	+	Frame_Shift_Del	DEL	TGAG	TGAG	-	rs150842067		TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr17:7572959_7572962delTGAG	ENST00000269305.4	-	11	1336_1339	c.1147_1150delCTCA	c.(1147-1152)tgfs	p.LM383fs	TP53_ENST00000445888.2_Frame_Shift_Del_p.LM383fs|TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000455263.2_3'UTR|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	383	Basic (repression of DNA-binding).|Interaction with CARM1.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(1)|p.L383F(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCTTGAACATGAGTTTTTTATGG	0.529		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	130	---	---	---	---					
CTBP2P3	220147	broad.mit.edu	37	18	58330742	58330742	+	RNA	DEL	C	C	-			TCGA-CQ-A4CD-01A-21D-A25D-08	TCGA-CQ-A4CD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c269ecd1-5a4e-43a7-a658-970a52ca8776	9efb8636-73b0-41db-92ef-e70e1bf83e44	g.chr18:58330742delC	ENST00000591869.1	-	0	228																											CCAGGCATGGCCAGAAGGCAC	0.612													2	4	---	---	---	---