Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDHB14	56122	broad.mit.edu	37	5	140604627	140604627	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:140604627G>C	ENST00000239449.4	+	1	1550	c.1550G>C	c.(1549-1551)aGg>aCg	p.R517T	PCDHB14_ENST00000515856.2_Missense_Mutation_p.R364T	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		517	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGCCCTCAGGTCGCTGGAC	0.682000													20	153					0	0	0.639603	0	0
LILRB2	10288	broad.mit.edu	37	19	54780728	54780728	+	Silent	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:54780728C>G	ENST00000391748.1	-	10	1540	c.1413G>C	c.(1411-1413)ctG>ctC	p.L471L	LILRB2_ENST00000391749.4_Silent_p.L472L|LILRB2_ENST00000434421.1_Silent_p.L356L|LILRB2_ENST00000391746.1_Silent_p.L472L|LILRB2_ENST00000314446.5_Silent_p.L471L	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	472					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggaggaggagcagtaggaCGA	0.582000													36	124					0	0	0.788014	0	0
VPS33B	26276	broad.mit.edu	37	15	91557072	91557072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:91557072G>A	ENST00000333371.3	-	5	672	c.319C>T	c.(319-321)Cga>Tga	p.R107*	VPS33B_ENST00000557358.1_5'UTR|VPS33B_ENST00000535906.1_Nonsense_Mutation_p.R80*|VPS33B_ENST00000535843.1_Nonsense_Mutation_p.R16*	NM_018668.3	NP_061138.3	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33 homolog B (yeast)	107					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|stomach(2)	16	Lung NSC(78;0.0987)|all_lung(78;0.175)					TTGCGAGTTCGGCCAGCCAAT	0.517000													40	146					0	0	0.840704	0	0
TRHDE	29953	broad.mit.edu	37	12	73014920	73014920	+	Silent	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:73014920T>C	ENST00000261180.4	+	14	2463	c.2367T>C	c.(2365-2367)taT>taC	p.Y789Y		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	789					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CAACAACATATATCAAGCTTG	0.313000													25	82					0	0	0.706142	0	0
C3	718	broad.mit.edu	37	19	6692960	6692960	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:6692960G>A	ENST00000245907.6	-	26	3457	c.3365C>T	c.(3364-3366)gCg>gTg	p.A1122V		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1122					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TATCACGGGCGCATCCTCCTG	0.557000													5	274					0	0	0.184627	0	0
COBLL1	22837	broad.mit.edu	37	2	165551667	165551667	+	Silent	SNP	C	C	A	rs61748611		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:165551667C>A	ENST00000375458.2	-	11	2456	c.2235G>T	c.(2233-2235)tcG>tcT	p.S745S	COBLL1_ENST00000194871.6_Silent_p.S850S|COBLL1_ENST00000392717.2_Silent_p.S821S|COBLL1_ENST00000409184.3_Silent_p.S783S|COBLL1_ENST00000342193.4_Silent_p.S783S	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	821										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						GCCAGTCTTTCGATATTTCCA	0.383000													5	321					0.248553	0.253184	0.248553	1	0
LRRC4C	57689	broad.mit.edu	37	11	40135934	40135934	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:40135934C>G	ENST00000278198.2	-	2	3872	c.1909G>C	c.(1909-1911)Gag>Cag	p.E637Q	LRRC4C_ENST00000527150.1_Missense_Mutation_p.E637Q|LRRC4C_ENST00000528697.1_Missense_Mutation_p.E637Q|LRRC4C_ENST00000530763.1_Missense_Mutation_p.E637Q			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	637					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				ATTTGAGTCTCTTGTACATTG	0.318000													18	97					0	0	0.539581	0	0
C5orf54	63920	broad.mit.edu	37	5	159821393	159821393	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:159821393C>A	ENST00000408953.3	-	2	1612	c.1105G>T	c.(1105-1107)Gag>Tag	p.E369*	C5orf54_ENST00000523213.1_Nonsense_Mutation_p.E369*	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	369										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						attttaaactctttattttca	0.353000													20	80					3.51602e-12	4.17845e-12	0.575678	1	0
DCAF17	80067	broad.mit.edu	37	2	172309702	172309702	+	Silent	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:172309702G>T	ENST00000375255.3	+	6	933	c.606G>T	c.(604-606)ggG>ggT	p.G202G	DCAF17_ENST00000539783.1_Silent_p.G202G|DCAF17_ENST00000468592.1_3'UTR	NM_025000.3	NP_079276.2	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17	202						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus		p.G202G(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)	17						CACTTGTAGGGATTCTAGAGA	0.328000													4	99					0.184627	0.189243	0.184627	1	0
MTNR1B	4544	broad.mit.edu	37	11	92715080	92715080	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:92715080C>T	ENST00000257068.2	+	2	697	c.691C>T	c.(691-693)Cgc>Tgc	p.R231C		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	231			R -> H (in dbSNP:rs8192553).		G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCTTCAGGCCCGCAGGAAAGC	0.582000													21	127					0	0	0.592651	0	0
COL4A3	1285	broad.mit.edu	37	2	228173694	228173694	+	Silent	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:228173694A>T	ENST00000396578.3	+	49	4704	c.4542A>T	c.(4540-4542)gcA>gcT	p.A1514A	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1514	Collagen IV NC1.|Required for the anti-angiogenic activity of tumstatin.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GTAATTTTGCATCTCGAAATG	0.433000													35	106					0	0	0.788014	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803554	142803554	+	RNA	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:142803554T>A	ENST00000423385.1	-	0	1411																											CTGATGAATCTGCAGTCAGGT	0.274000													5	226					0	0	0.184627	0	0
HECTD4	283450	broad.mit.edu	37	12	112617111	112617111	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:112617111G>A	ENST00000550722.1	-	63	11035	c.10640C>T	c.(10639-10641)gCg>gTg	p.A3547V	HECTD4_ENST00000377560.5_Missense_Mutation_p.A3521V|HECTD4_ENST00000430131.2_Missense_Mutation_p.A3271V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GATGGGCTTCGCTGGTGTCAG	0.547000													7	29					0	0	0.248553	0	0
SCUBE1	80274	broad.mit.edu	37	22	43617226	43617226	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:43617226G>C	ENST00000360835.3	-	13	1628	c.1502C>G	c.(1501-1503)cCc>cGc	p.P501R		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	501					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				CTGGCTGTGGGGCCGGAGGTG	0.642000													18	56					0	0	0.539581	0	0
CSMD3	114788	broad.mit.edu	37	8	114111056	114111056	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:114111056T>C	ENST00000297405.5	-	5	1090	c.846A>G	c.(844-846)atA>atG	p.I282M	CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000352409.3_Missense_Mutation_p.I282M|CSMD3_ENST00000343508.3_Missense_Mutation_p.I242M|CSMD3_ENST00000455883.2_Missense_Mutation_p.I282M	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	282	CUB 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AATCAGTAAATATGAGTGAAA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	118					0	0	0.667858	0	0
FAT2	2196	broad.mit.edu	37	5	150885275	150885275	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:150885275G>A	ENST00000261800.5	-	23	12913	c.12901C>T	c.(12901-12903)Cgc>Tgc	p.R4301C		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4301					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGGCTGAGGCGCATACCCACC	0.667000													4	73					0	0	0.150653	0	0
YIPF7	285525	broad.mit.edu	37	4	44626759	44626759	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:44626759G>T	ENST00000332990.5	-	5	555	c.539C>A	c.(538-540)gCc>gAc	p.A180D		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	180						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						GCAGCCAATGGCACTCATGCC	0.507000													3	15					1.23904e-05	1.37299e-05	0.184627	1	0
KDM6A	7403	broad.mit.edu	37	X	44929602	44929602	+	Splice_Site	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chrX:44929602G>T	ENST00000377967.4	+	17	2743	c.2702_splice	c.e17+1	p.R901_splice	KDM6A_ENST00000543216.1_Splice_Site_p.R822_splice|KDM6A_ENST00000382899.4_Splice_Site_p.R908_splice|KDM6A_ENST00000536777.1_Splice_Site_p.R856_splice	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	901					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.R901K(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						AAGGCATGCAGGTTAGTGTGG	0.418000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								9	13					4.68919e-08	5.37781e-08	0.361761	1	0
GRM6	2916	broad.mit.edu	37	5	178413301	178413301	+	Missense_Mutation	SNP	C	C	T	rs150850494		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:178413301C>T	ENST00000231188.5	-	8	2132	c.1954G>A	c.(1954-1956)Gcc>Acc	p.A652T	GRM6_ENST00000517717.1_Missense_Mutation_p.A652T|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	652					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGCCTGCGGGCGGCACAGACC	0.642000													4	21					0	0	0.184627	0	0
CPN2	1370	broad.mit.edu	37	3	194062541	194062541	+	Silent	SNP	G	G	A	rs140809499	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:194062541G>A	ENST00000323830.3	-	2	980	c.891C>T	c.(889-891)acC>acT	p.T297T	CPN2_ENST00000429275.1_Silent_p.T297T	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	297					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCTGGTTATGGGTCAGAGACA	0.587000													25	64					0	0	0.717897	0	0
KRT16	3868	broad.mit.edu	37	17	39767694	39767694	+	Missense_Mutation	SNP	C	C	A	rs142812826	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:39767694C>A	ENST00000301653.4	-	3	738	c.674G>T	c.(673-675)cGg>cTg	p.R225L		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	225	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				ATCCAACACCCGGCGCAGGCC	0.622000													25	101					4.87955e-14	5.84122e-14	0.693898	1	0
C22orf31	25770	broad.mit.edu	37	22	29454807	29454807	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:29454807A>C	ENST00000216071.4	-	3	847	c.796T>G	c.(796-798)Ttc>Gtc	p.F266V		NM_015370.1	NP_056185.1	O95567	CV031_HUMAN	chromosome 22 open reading frame 31	266										cervix(1)|endometrium(1)|kidney(17)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	27						CTGCCAGGGAACCGGTCCCTC	0.522000													17	154					0	0	0.520397	0	0
TOMM34	10953	broad.mit.edu	37	20	43572117	43572117	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr20:43572117C>T	ENST00000372813.3	-	6	954	c.802G>A	c.(802-804)Gct>Act	p.A268T	PABPC1L_ENST00000372819.1_Intron|PABPC1L_ENST00000490798.1_Intron	NM_006809.4	NP_006800.2	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	268					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	11		Myeloproliferative disorder(115;0.0122)				TGGGCTTGAGCCCGTCTGTAG	0.473000													5	222					0	0	0.248553	0	0
PKHD1	5314	broad.mit.edu	37	6	51893027	51893027	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:51893027C>T	ENST00000371117.3	-	30	3762	c.3487G>A	c.(3487-3489)Gca>Aca	p.A1163T	PKHD1_ENST00000340994.4_Missense_Mutation_p.A1163T	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1163	IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GGGGGCAGTGCCACCTCCAGG	0.547000													5	212					0	0	0.184627	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210308	30210308	+	RNA	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:30210308G>A	ENST00000518096.1	+	0	920																											CCCTTCCCACGTCTCCATTTC	0.562000													15	123					0	0	0.479597	0	0
STXBP3	6814	broad.mit.edu	37	1	109295688	109295688	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:109295688A>T	ENST00000370008.3	+	3	153	c.103A>T	c.(103-105)Atg>Ttg	p.M35L		NM_007269.2	NP_009200.2	O00186	STXB3_HUMAN	syntaxin binding protein 3	35	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TTTTAAGATAATGCTTTTAGA	0.289000													36	110					0	0	0.779181	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:95522815A>G	ENST00000432432.2	-	0	212					NR_040113.1																						ATCTTCTGCAATTCGGAGTCC	0.652000													6	85					0	0	0.278610	0	0
ZFAND4	93550	broad.mit.edu	37	10	46121636	46121636	+	Silent	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:46121636C>T	ENST00000374366.3	-	8	1878	c.1413G>A	c.(1411-1413)gaG>gaA	p.E471E	ZFAND4_ENST00000344646.5_Silent_p.E545E|ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Intron			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	545							zinc ion binding										TATCCCGAGCCTCAACTTTGG	0.398000													45	165					0	0	0.847076	0	0
EPHB4	2050	broad.mit.edu	37	7	100414856	100414856	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:100414856C>T	ENST00000358173.3	-	8	2014	c.1546G>A	c.(1546-1548)Ggg>Agg	p.G516R	EPHB4_ENST00000360620.3_Missense_Mutation_p.G516R|EPHB4_ENST00000477446.1_Intron	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	516	Fibronectin type-III 2.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCGAAGGGCCCGTAGCCGGCC	0.657000													7	31					0	0	0.307466	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													6	68					0	0	0.217242	0	0
MYO5A	4644	broad.mit.edu	37	15	52672048	52672048	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:52672048G>A	ENST00000399231.3	-	17	2313	c.2070C>T	c.(2068-2070)atC>atT	p.I690I	MYO5A_ENST00000553916.1_Silent_p.I690I|MYO5A_ENST00000358212.6_Silent_p.I690I|MYO5A_ENST00000399233.2_Silent_p.I690I|MYO5A_ENST00000356338.6_Silent_p.I690I	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	690	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CACTGATTCGGATGGTTTCCA	0.473000													43	190					0	0	0.870114	0	0
ADCY8	114	broad.mit.edu	37	8	131793033	131793033	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:131793033C>T	ENST00000286355.5	-	18	5451	c.3359G>A	c.(3358-3360)cGa>cAa	p.R1120Q	ADCY8_ENST00000377928.3_Missense_Mutation_p.R989Q	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1120					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCTGTCCATTCGGCTTGCCAG	0.567000										HNSCC(32;0.087)			64	304					0	0	0.870114	0	0
ZNF12	7559	broad.mit.edu	37	7	6731084	6731084	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:6731084C>A	ENST00000405858.1	-	5	2030	c.1489G>T	c.(1489-1491)Gaa>Taa	p.E497*	AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Nonsense_Mutation_p.E423*|ZNF12_ENST00000342651.5_Nonsense_Mutation_p.E459*	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	497					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TTTCCACATTCATTACATTCG	0.398000													48	180					2.65591e-33	3.57024e-33	0.870114	1	0
VWA2	340706	broad.mit.edu	37	10	116045935	116045935	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:116045935G>A	ENST00000603594.1	+	11	1556	c.1235G>A	c.(1234-1236)gGc>gAc	p.G412D	VWA2_ENST00000392982.3_Missense_Mutation_p.G412D	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	412	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		AGCCTCGATGGCATTCCCTTC	0.697000													4	133					0	0	0.150653	0	0
NOC2L	26155	broad.mit.edu	37	1	889227	889227	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:889227G>A	ENST00000327044.6	-	8	872	c.823C>T	c.(823-825)Cgg>Tgg	p.R275W		NM_015658.3	NP_056473.2	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	275						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CTGATGTGCCGCAGCACGGCC	0.617000													7	53					0	0	0.278610	0	0
RFT1	91869	broad.mit.edu	37	3	53156407	53156407	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:53156407T>C	ENST00000296292.3	-	4	500	c.439A>G	c.(439-441)Atg>Gtg	p.M147V	RFT1_ENST00000394738.3_Missense_Mutation_p.M108V	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	147					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		TTCACAAACATATGTGCTTGT	0.443000													44	93					0	0	0.870114	0	0
AHCYL2	23382	broad.mit.edu	37	7	129053482	129053482	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:129053482A>G	ENST00000325006.3	+	12	1468	c.1414A>G	c.(1414-1416)Agc>Ggc	p.S472G	AHCYL2_ENST00000446212.1_Missense_Mutation_p.S370G|AHCYL2_ENST00000490911.1_Missense_Mutation_p.S369G|AHCYL2_ENST00000531335.2_Missense_Mutation_p.S391G|AHCYL2_ENST00000446544.2_Missense_Mutation_p.S471G|AHCYL2_ENST00000474594.1_Missense_Mutation_p.S369G	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	472					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						TATGAAGAATAGCTGCATCGT	0.428000													23	104					0	0	0.681144	0	0
CXCL10	3627	broad.mit.edu	37	4	76943875	76943875	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:76943875C>G	ENST00000306602.1	-	2	222	c.157G>C	c.(157-159)Gca>Cca	p.A53P	ART3_ENST00000341029.5_Intron	NM_001565.3	NP_001556.2	P02778	CXL10_HUMAN	chemokine (C-X-C motif) ligand 10	53					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity			kidney(1)|large_intestine(1)|lung(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AATTGGCTTGCAGGAATAATT	0.363000													17	103					0	0	0.557998	0	0
FAM135B	51059	broad.mit.edu	37	8	139164635	139164635	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:139164635C>A	ENST00000395297.1	-	13	2253	c.2083G>T	c.(2083-2085)Gtc>Ttc	p.V695F		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	695										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GACCAGGCGACGGAGCTTGGC	0.552000										HNSCC(54;0.14)			30	97					1.32181e-22	1.72045e-22	0.717897	1	0
OR8D4	338662	broad.mit.edu	37	11	123777296	123777296	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:123777296G>A	ENST00000321355.2	+	1	188	c.158G>A	c.(157-159)cGt>cAt	p.R53H		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AGGCTGAATCGTCAACTTCAT	0.408000													58	282					0	0	0.870114	0	0
KCNT2	343450	broad.mit.edu	37	1	196205130	196205130	+	Silent	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:196205130C>T	ENST00000367433.5	-	26	3311	c.3210G>A	c.(3208-3210)gaG>gaA	p.E1070E	KCNT2_ENST00000294725.8_Silent_p.E1094E|KCNT2_ENST00000367431.4_Silent_p.E1028E|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_3'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1094						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CATCATTCAGCTCTATTCTGG	0.313000													89	298					0	0	0.870114	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617803	111617803	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:111617803G>A	ENST00000374667.3	-	1	1436	c.408C>T	c.(406-408)acC>acT	p.T136T		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	136						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCTTCATGGCGGTGCGGAAGA	0.622000													32	60					0	0	0.740014	0	0
POLI	11201	broad.mit.edu	37	18	51800403	51800403	+	Missense_Mutation	SNP	G	G	T	rs142974796	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:51800403G>T	ENST00000579534.1	+	3	492	c.349G>T	c.(349-351)Gta>Tta	p.V117L	POLI_ENST00000406285.3_Missense_Mutation_p.V117L|POLI_ENST00000579434.1_Missense_Mutation_p.V14L|POLI_ENST00000217800.5_Missense_Mutation_p.V14L	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	117	UmuC.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		TCCACAGTTGGTATTAGTTAA	0.348000								DNA polymerases (catalytic subunits)					11	27					3.03607e-14	3.66115e-14	0.411799	1	0
APOBEC3D	140564	broad.mit.edu	37	22	39427930	39427930	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:39427930T>C	ENST00000216099.7	+	6	1401	c.994T>C	c.(994-996)Tgc>Cgc	p.C332R	APOBEC3D_ENST00000427494.2_Missense_Mutation_p.C148R|APOBEC3D_ENST00000381568.4_Missense_Mutation_p.C332R	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	332					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					GGAGGGGCTCTGCAGCCTGAG	0.617000													11	139					0	0	0.624587	0	0
ESM1	11082	broad.mit.edu	37	5	54275232	54275232	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:54275232A>G	ENST00000381405.4	-	3	628	c.483T>C	c.(481-483)atT>atC	p.I161I	ESM1_ENST00000598310.1_5'UTR|ESM1_ENST00000381403.4_Silent_p.I111I	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	161					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			CTTCTCTCACAATATTGCCAT	0.433000													19	134					0	0	0.557998	0	0
FOXC2	2303	broad.mit.edu	37	16	86601397	86601397	+	Silent	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:86601397C>A	ENST00000320354.4	+	1	541	c.456C>A	c.(454-456)tcC>tcA	p.S152S		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	152					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						ACCCGGACTCCTACAACATGT	0.627000									Late-onset Hereditary Lymphedema				30	98					1.74807e-11	2.06247e-11	0.750413	1	0
MARK1	4139	broad.mit.edu	37	1	220825399	220825399	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:220825399G>T	ENST00000402574.1	+	15	2240	c.1238G>T	c.(1237-1239)cGa>cTa	p.R413L	MARK1_ENST00000366917.4_Missense_Mutation_p.R548L|MARK1_ENST00000366918.4_Missense_Mutation_p.R526L	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	548					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		CCCTCAGCACGACCCCGCCAC	0.512000													20	116					0.00152264	0.00163211	0.592651	1	0
ALPK2	115701	broad.mit.edu	37	18	56246569	56246569	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:56246569G>A	ENST00000361673.3	-	4	1652	c.1439C>T	c.(1438-1440)gCc>gTc	p.A480V		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	480							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						ATTGTCACTGGCAAATTCCTC	0.478000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	209					0	0	0.150653	0	0
SCAI	286205	broad.mit.edu	37	9	127765428	127765428	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:127765428T>A	ENST00000336505.5	-	11	1088	c.1030A>T	c.(1030-1032)Agc>Tgc	p.S344C	SCAI_ENST00000487795.1_5'UTR|SCAI_ENST00000373549.4_Missense_Mutation_p.S367C	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion	344					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						TATAGCTGGCTGAAGGTTGGT	0.383000													193	340					0	0	0.870114	0	0
CAPN15	6650	broad.mit.edu	37	16	602492	602492	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:602492A>T	ENST00000219611.2	+	11	3062	c.2699A>T	c.(2698-2700)cAc>cTc	p.H900L	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		GCCTTCAACCACTGGGGGCCG	0.706000													8	24					0	0	0.307466	0	0
MED12L	116931	broad.mit.edu	37	3	151129183	151129183	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:151129183G>A	ENST00000474524.1	+	39	5961	c.5923G>A	c.(5923-5925)Gca>Aca	p.A1975T	MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1975	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTATCCGGCCGCACATTCCAA	0.572000													4	164					0	0	0.150653	0	0
SLC6A12	6539	broad.mit.edu	37	12	306025	306025	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:306025A>C	ENST00000428720.1	-	11	1842	c.1099T>G	c.(1099-1101)Ttc>Gtc	p.F367V	SLC6A12_ENST00000536824.1_Missense_Mutation_p.F367V|SLC6A12_ENST00000397296.2_Missense_Mutation_p.F367V|SLC6A12_ENST00000359674.4_Missense_Mutation_p.F367V|SLC6A12_ENST00000424061.2_Missense_Mutation_p.F367V	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	367					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GCCTTGGGGAAGGCGATGAAG	0.582000													14	73					0	0	0.435327	0	0
MARCH7	64844	broad.mit.edu	37	2	160604745	160604745	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:160604745A>T	ENST00000259050.3	+	5	1066	c.944A>T	c.(943-945)tAc>tTc	p.Y315F	MARCH7_ENST00000409591.1_Missense_Mutation_p.Y277F|MARCH7_ENST00000409175.1_Missense_Mutation_p.Y315F|MARCH7_ENST00000539065.1_Missense_Mutation_p.Y259F	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	315	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						GAAAATTCTTACGTTTCTCCA	0.398000													26	94					0	0	0.693898	0	0
EPHA2	1969	broad.mit.edu	37	1	16475542	16475542	+	Splice_Site	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:16475542A>C	ENST00000358432.5	-	3	308	c.153_splice	c.e3-1	p.W52_splice	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	52					activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ATCAGGTCCCACTGTGGGGGG	0.557000													11	58					0	0	0.361761	0	0
FOXP4	116113	broad.mit.edu	37	6	41565600	41565600	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:41565600C>A	ENST00000373060.1	+	16	2265	c.1807C>A	c.(1807-1809)Ctc>Atc	p.L603I	FOXP4_ENST00000307972.4_Missense_Mutation_p.L603I|FOXP4_ENST00000373057.3_Missense_Mutation_p.L601I|FOXP4_ENST00000409208.1_Missense_Mutation_p.L591I|FOXP4_ENST00000373063.3_Missense_Mutation_p.L590I	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	603					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCTGCTGCCCCTCAGCCACGA	0.706000											OREG0004068	type=REGULATORY REGION|Gene=FOXP4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	13					0.115264	0.119641	0.115264	1	0
EML4	27436	broad.mit.edu	37	2	42557100	42557100	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:42557100C>G	ENST00000318522.5	+	23	2961	c.2699C>G	c.(2698-2700)cCg>cGg	p.P900R	EML4_ENST00000401738.3_Missense_Mutation_p.P911R|EML4_ENST00000453191.2_Missense_Mutation_p.P164R|EML4_ENST00000402711.2_Missense_Mutation_p.P842R	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	900					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding	p.P900L(1)	EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						ACTCCCACACCGCCTCCTTCT	0.473000			T	ALK	NSCLC								33	133					0	0	0.750413	0	0
RYR2	6262	broad.mit.edu	37	1	237870464	237870464	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:237870464A>T	ENST00000366574.2	+	68	10113	c.9796A>T	c.(9796-9798)Aca>Tca	p.T3266S	RYR2_ENST00000542537.1_Missense_Mutation_p.T3250S|RYR2_ENST00000360064.6_Missense_Mutation_p.T3264S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3266					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATGTGCTGCACAGCCCTGAA	0.478000													11	60					0	0	0.361761	0	0
UNC13C	440279	broad.mit.edu	37	15	54919300	54919300	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:54919300G>T	ENST00000545554.1	+	32	6634	c.6634G>T	c.(6634-6636)Gag>Tag	p.E2212*	UNC13C_ENST00000537900.1_Nonsense_Mutation_p.E2210*|UNC13C_ENST00000260323.11_Nonsense_Mutation_p.E2212*|UNC13C_ENST00000539562.2_Nonsense_Mutation_p.E133*			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2212					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCTACTGAAGAGAGTGCTTG	0.353000													12	28					1.08611e-07	1.23696e-07	0.387290	1	0
TCP11L2	255394	broad.mit.edu	37	12	106717343	106717343	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:106717343A>G	ENST00000546625.1	+	6	850	c.691A>G	c.(691-693)Atg>Gtg	p.M231V	TCP11L2_ENST00000552690.1_3'UTR|TCP11L2_ENST00000547153.1_Missense_Mutation_p.M231V|TCP11L2_ENST00000299045.3_Missense_Mutation_p.M231V			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	231										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						TTTTACAATTATGAGTCTCAG	0.363000													15	79					0	0	0.479597	0	0
PIK3R5	23533	broad.mit.edu	37	17	8792082	8792082	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:8792082G>A	ENST00000447110.1	-	10	1146	c.1022C>T	c.(1021-1023)gCc>gTc	p.A341V	PIK3R5_ENST00000584803.1_Missense_Mutation_p.A341V|PIK3R5_ENST00000581552.1_Missense_Mutation_p.A341V	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	341				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						ATCTCTCTCGGCACAGTGCCC	0.617000													3	36					0	0	0.115264	0	0
WHSC1	7468	broad.mit.edu	37	4	1957915	1957915	+	Splice_Site	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:1957915G>T	ENST00000382895.3	+	17	3312	c.2881_splice	c.e17+1	p.A961_splice	WHSC1_ENST00000382888.3_Splice_Site_p.A309_splice|WHSC1_ENST00000508803.1_Splice_Site_p.A961_splice|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382891.5_Splice_Site_p.A961_splice|WHSC1_ENST00000382892.2_Splice_Site_p.A961_splice	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	961					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CTTCAAAAACGGTACGGAGAT	0.463000			T	IGH@	MM								15	138					2.31682e-05	2.55006e-05	0.479597	1	0
IL12A	3592	broad.mit.edu	37	3	159710911	159710911	+	Splice_Site	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:159710911A>T	ENST00000305579.2	+	3	684	c.378_splice	c.e3+1	p.K126_splice	IL12A_ENST00000480787.1_Intron|IL12A_ENST00000466512.1_Splice_Site_p.K126_splice|CTD-2049J23.2_ENST00000497452.1_RNA	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	92					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAATTAACCAAGGTATAAAGG	0.383000													24	99					0	0	0.681144	0	0
BCL2L11	10018	broad.mit.edu	37	2	111907687	111907687	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:111907687G>T	ENST00000393256.3	+	3	734	c.461G>T	c.(460-462)cGt>cTt	p.R154L	BCL2L11_ENST00000393253.2_Missense_Mutation_p.R64L|BCL2L11_ENST00000308659.8_Missense_Mutation_p.R94L|BCL2L11_ENST00000357757.2_Missense_Mutation_p.R154L	NM_001204106.1|NM_006538.4|NM_138621.4|NM_138627.3	NP_001191035.1|NP_006529.1|NP_619527.1|NP_619533.1	O43521	B2L11_HUMAN	BCL2-like 11 (apoptosis facilitator)	154					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(3)|lung(2)|prostate(2)	11						GAGTTGCGGCGTATTGGAGAC	0.448000													11	45					2.10051e-16	2.62964e-16	0.411799	1	0
PCDH10	57575	broad.mit.edu	37	4	134071805	134071805	+	Silent	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:134071805C>T	ENST00000264360.4	+	1	1336	c.510C>T	c.(508-510)gaC>gaT	p.D170D		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	170	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		TCTCCCTGGACGTGCAGACCC	0.637000													20	101					0	0	0.575678	0	0
HLA-A	3105	broad.mit.edu	37	6	29910693	29910693	+	Missense_Mutation	SNP	A	A	G	rs41559716	by1000genomes	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:29910693A>G	ENST00000396634.1	+	4	574	c.233A>G	c.(232-234)cAg>cGg	p.Q78R	HLA-A_ENST00000376802.2_Missense_Mutation_p.Q78R|HLA-A_ENST00000376809.5_Missense_Mutation_p.Q78R|HLA-A_ENST00000376806.5_Missense_Mutation_p.Q78R			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.Q78R(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TGGATAGAGCAGGAGGGGCCG	0.657000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			3	15					0	0	0.184627	0	0
LRP1B	53353	broad.mit.edu	37	2	141283518	141283518	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:141283518T>A	ENST00000389484.3	-	49	8892	c.7921A>T	c.(7921-7923)Aca>Tca	p.T2641S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2641	LDL-receptor class A 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGAACCCTGTGGTTTTCACT	0.383000										TSP Lung(27;0.18)			22	64					0	0	0.639603	0	0
NMS	129521	broad.mit.edu	37	2	101087010	101087010	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:101087010A>G	ENST00000376865.1	+	1	67	c.60A>G	c.(58-60)ctA>ctG	p.L20L		NM_001011717.1	NP_001011717.1	Q5H8A3	NMS_HUMAN	neuromedin S	20					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				breast(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)	14						TCTGCATGCTACAGATTCCCT	0.537000													34	153					0	0	0.788014	0	0
ELTD1	64123	broad.mit.edu	37	1	79383352	79383352	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:79383352C>A	ENST00000370742.3	-	12	1779	c.1716G>T	c.(1714-1716)tgG>tgT	p.W572C		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	572					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTATAAAACTCCAAATAAAGT	0.279000													10	46					3.86212e-05	4.19462e-05	0.361761	1	0
SEC31A	22872	broad.mit.edu	37	4	83770026	83770026	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:83770026C>A	ENST00000432794.1	-	20	2596	c.2433G>T	c.(2431-2433)aaG>aaT	p.K811N	SEC31A_ENST00000348405.4_Missense_Mutation_p.K772N|SEC31A_ENST00000326950.5_Missense_Mutation_p.K772N|SEC31A_ENST00000395310.2_Missense_Mutation_p.K811N|SEC31A_ENST00000311785.7_Missense_Mutation_p.K811N|SEC31A_ENST00000513858.1_Missense_Mutation_p.K772N|SEC31A_ENST00000508479.1_Missense_Mutation_p.K811N|SEC31A_ENST00000505472.1_Missense_Mutation_p.K811N|SEC31A_ENST00000264405.5_Missense_Mutation_p.K544N|SEC31A_ENST00000355196.2_Missense_Mutation_p.K811N|SEC31A_ENST00000509142.1_Missense_Mutation_p.K811N|SEC31A_ENST00000508502.1_Missense_Mutation_p.K811N|SEC31A_ENST00000505984.1_Missense_Mutation_p.K772N|SEC31A_ENST00000500777.2_Missense_Mutation_p.K772N|SEC31A_ENST00000448323.1_Missense_Mutation_p.K811N|SEC31A_ENST00000443462.2_Missense_Mutation_p.K806N			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	811	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				CAGGCCTGCCCTTGGGGAGCT	0.488000													28	118					1.88708e-17	2.38063e-17	0.729181	1	0
TRPC4	7223	broad.mit.edu	37	13	38266248	38266248	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr13:38266248C>G	ENST00000379705.3	-	4	1979	c.1122G>C	c.(1120-1122)ttG>ttC	p.L374F	TRPC4_ENST00000338947.5_Missense_Mutation_p.L201F|TRPC4_ENST00000447043.1_Missense_Mutation_p.L374F|TRPC4_ENST00000379679.1_Missense_Mutation_p.L201F|TRPC4_ENST00000355779.2_Missense_Mutation_p.L374F|TRPC4_ENST00000426868.2_Missense_Mutation_p.L374F|TRPC4_ENST00000358477.2_Missense_Mutation_p.L374F|TRPC4_ENST00000379673.2_Missense_Mutation_p.L374F|TRPC4_ENST00000379681.3_Missense_Mutation_p.L374F			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	374					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACAAAAAAGTCAAATAGGAGG	0.483000													18	65					0	0	0.592651	0	0
ZIK1	284307	broad.mit.edu	37	19	58102416	58102416	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:58102416G>A	ENST00000597850.1	+	4	1452	c.1237G>A	c.(1237-1239)Ggg>Agg	p.G413R	ZIK1_ENST00000536878.2_Missense_Mutation_p.G400R|ZIK1_ENST00000599456.1_Missense_Mutation_p.G358R|ZIK1_ENST00000307468.4_3'UTR	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGTGACTGTGGGAAATCCTT	0.458000													16	77					0	0	0.479597	0	0
FBN2	2201	broad.mit.edu	37	5	127670537	127670537	+	Splice_Site	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:127670537C>A	ENST00000508053.1	-	37	4948		c.e37-1		FBN2_ENST00000507835.1_Splice_Site|FBN2_ENST00000508989.1_Splice_Site|FBN2_ENST00000262464.4_Splice_Site			P35556	FBN2_HUMAN	fibrillin 2						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATTGACATCTAGAAAATTT	0.348000													4	102					0.184627	0.189243	0.184627	1	0
GRM1	2911	broad.mit.edu	37	6	146755141	146755141	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:146755141C>A	ENST00000361719.2	+	9	3264	c.2794C>A	c.(2794-2796)Ccc>Acc	p.P932T	GRM1_ENST00000392299.2_3'UTR|GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000282753.1_Missense_Mutation_p.P932T	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	932					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGTCATCAAGCCCCTCACTAA	0.557000													33	136					7.11191e-15	8.70413e-15	0.769981	1	0
TBR1	10716	broad.mit.edu	37	2	162274270	162274270	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:162274270C>T	ENST00000389554.3	+	2	1093	c.776C>T	c.(775-777)gCg>gTg	p.A259V		NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	259						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.A259V(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						GTGATTTTGGCGGATCCCAAT	0.423000													4	231					0	0	0.150653	0	0
ZNF536	9745	broad.mit.edu	37	19	30936347	30936347	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:30936347G>A	ENST00000355537.3	+	2	2025	c.1878G>A	c.(1876-1878)atG>atA	p.M626I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTGGGAACATGAAGGAGAAGC	0.597000													58	222					0	0	0.870114	0	0
WNK4	65266	broad.mit.edu	37	17	40948502	40948502	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:40948502T>A	ENST00000246914.5	+	18	3656	c.3635T>A	c.(3634-3636)aTc>aAc	p.1212_1212insN		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	0					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTCCCAGGCATCATGCGAAGG	0.647000													22	67					0	0	0.693898	0	0
BTAF1	9044	broad.mit.edu	37	10	93748998	93748998	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:93748998C>A	ENST00000265990.6	+	20	2823	c.2515C>A	c.(2515-2517)Caa>Aaa	p.Q839K	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	839					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				ACAGCAGGTCCAAATGACAGT	0.418000													10	78					7.48243e-07	8.40492e-07	0.335167	1	0
APOBEC3B	9582	broad.mit.edu	37	22	39385564	39385564	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:39385564C>A	ENST00000402182.3	+	5	727	c.672C>A	c.(670-672)gaC>gaA	p.D224E	APOBEC3B_ENST00000333467.3_Missense_Mutation_p.D224E|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.D224E			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	224					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					AGCGCCTGGACAATGGCACCT	0.562000													17	70					1.67942e-08	1.93961e-08	0.539581	1	0
KRTAP13-3	337960	broad.mit.edu	37	21	31798152	31798152	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr21:31798152C>A	ENST00000390690.2	-	1	134	c.79G>T	c.(79-81)Ggc>Tgc	p.G27C		NM_181622.1	NP_853653.1	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	27						intermediate filament				endometrium(1)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	14						TAGGAAGAGCCACAGGAGGAG	0.567000													34	136					2.20474e-14	2.67835e-14	0.788014	1	0
TP53	7157	broad.mit.edu	37	17	7576853	7576853	+	Splice_Site	SNP	C	C	T	rs11575996		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7576853C>T	ENST00000420246.2	-	9	1125	c.993_splice	c.e9+1	p.Q331_splice	TP53_ENST00000455263.2_Splice_Site_p.Q331_splice|TP53_ENST00000445888.2_Splice_Site_p.Q331_splice|TP53_ENST00000359597.4_Splice_Site_p.Q331_splice|TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Splice_Site_p.Q331_splice	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	331	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		Q -> H (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.Q331H(7)|p.Q331P(2)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			56	79					0	0	0.870114	0	0
NME7	29922	broad.mit.edu	37	1	169200035	169200035	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:169200035G>C	ENST00000367811.3	-	10	1167	c.911C>G	c.(910-912)tCt>tGt	p.S304C	NME7_ENST00000472647.1_Missense_Mutation_p.S268C	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	304					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					ACAAGGGCCAGAATACATTTC	0.323000													29	54					0	0	0.779181	0	0
CACNA1D	776	broad.mit.edu	37	3	53699745	53699745	+	Silent	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:53699745C>A	ENST00000288139.3	+	6	943	c.825C>A	c.(823-825)gcC>gcA	p.A275A	CACNA1D_ENST00000350061.5_Silent_p.A275A|CACNA1D_ENST00000422281.2_Silent_p.A275A	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	275					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTCACATAGCCCTTTTGGTAT	0.353000													36	148					1.04594e-18	1.32972e-18	0.819951	1	0
MDGA2	161357	broad.mit.edu	37	14	47426789	47426789	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr14:47426789A>C	ENST00000426342.1	-	9	1729	c.983T>G	c.(982-984)gTc>gGc	p.V328G	MDGA2_ENST00000357362.3_Missense_Mutation_p.V328G|MDGA2_ENST00000399232.2_Missense_Mutation_p.V626G|MDGA2_ENST00000439988.2_Missense_Mutation_p.V557G	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	557	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						ACTCATAGTGACACTTCGATC	0.458000													28	118					0	0	0.729181	0	0
TMEM71	137835	broad.mit.edu	37	8	133764056	133764056	+	Missense_Mutation	SNP	C	C	A	rs111461300	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:133764056C>A	ENST00000356838.3	-	4	431	c.289G>T	c.(289-291)Gtt>Ttt	p.V97F	TMEM71_ENST00000377901.4_Missense_Mutation_p.V97F|TMEM71_ENST00000523829.1_Missense_Mutation_p.V97F|TMEM71_ENST00000517538.1_5'UTR	NM_144649.2	NP_653250.2	Q6P5X7	TMM71_HUMAN	transmembrane protein 71	97						integral to membrane				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTATACATAACGCTGGTCTGG	0.398000													54	233					3.21867e-24	4.2229e-24	0.870114	1	0
ACSM2B	348158	broad.mit.edu	37	16	20554262	20554262	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:20554262T>G	ENST00000329697.6	-	12	1651	c.1483A>C	c.(1483-1485)Agc>Cgc	p.S495R	ACSM2B_ENST00000567001.1_Missense_Mutation_p.S495R|ACSM2B_ENST00000565322.1_Missense_Mutation_p.S416R|ACSM2B_ENST00000565232.1_Missense_Mutation_p.S495R	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	495					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCTGGGCTGCTGATCACAGCC	0.537000													18	92					0	0	0.575678	0	0
RASSF4	83937	broad.mit.edu	37	10	45480280	45480280	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:45480280G>A	ENST00000374417.2	+	5	435	c.301G>A	c.(301-303)Gga>Aga	p.G101R	RASSF4_ENST00000472561.1_3'UTR|RASSF4_ENST00000334940.6_Silent_p.E140E|RASSF4_ENST00000340258.4_Silent_p.E131E			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	101					cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						AGGAGGCAGAGGAGGCCCCCC	0.667000													26	205					0	0	0.706142	0	0
KDM6B	23135	broad.mit.edu	37	17	7755572	7755572	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7755572G>A	ENST00000254846.5	+	19	4775	c.4386G>A	c.(4384-4386)gtG>gtA	p.V1462V	KDM6B_ENST00000448097.2_Silent_p.V1462V	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1462	JmjC.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GAGACCTCGTGTGGATTAATG	0.607000											OREG0024145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	106					0	0	0.788014	0	0
GYPE	2996	broad.mit.edu	37	4	144826671	144826671	+	Translation_Start_Site	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:144826671C>T	ENST00000358615.4	-	0	41				GYPE_ENST00000437468.2_De_novo_Start_OutOfFrame	NM_198682.2	NP_941391.2	P15421	GLPE_HUMAN	glycophorin E (MNS blood group)							integral to plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_hematologic(180;0.158)					CCTGAGATCACGAGCTGGCTC	0.398000													4	80					0	0	0.150653	0	0
CALCA	796	broad.mit.edu	37	11	14989331	14989331	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:14989331G>T	ENST00000361010.3	-	4	371	c.297C>A	c.(295-297)agC>agA	p.S99R	CALCA_ENST00000486207.1_Missense_Mutation_p.S99R|CALCB_ENST00000523376.1_Intron	NM_001033953.2	NP_001029125.1	P06881	CALCA_HUMAN	calcitonin-related polypeptide alpha	99					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	8					Phentolamine(DB00692)	CCCCTGATCTGCTCAGCAAGC	0.542000													27	81					3.01185e-09	3.50314e-09	0.667858	1	0
SIRPD	128646	broad.mit.edu	37	20	1532406	1532406	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr20:1532406C>T	ENST00000381623.3	-	2	1541	c.352G>A	c.(352-354)Gtg>Atg	p.V118M	SIRPD_ENST00000381621.1_Missense_Mutation_p.V118M			Q9H106	SIRPD_HUMAN	signal-regulatory protein delta	118	Ig-like V-type.					extracellular region				breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)	15						ATGAACTTCACGCAGTAATAG	0.488000													22	100					0	0	0.608945	0	0
CNTLN	54875	broad.mit.edu	37	9	17236462	17236462	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:17236462A>T	ENST00000380647.3	+	5	809	c.725A>T	c.(724-726)aAt>aTt	p.N242I	CNTLN_ENST00000380641.4_Missense_Mutation_p.N242I|CNTLN_ENST00000425824.1_Missense_Mutation_p.N242I|CNTLN_ENST00000262360.5_Missense_Mutation_p.N242I			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	242						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		GTTATAAAAAATCTGGAGGAG	0.378000													30	142					0	0	0.740014	0	0
SPRTN	83932	broad.mit.edu	37	1	231488769	231488769	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:231488769T>C	ENST00000295050.7	+	5	1468	c.1132T>C	c.(1132-1134)Tcc>Ccc	p.S378P	SPRTN_ENST00000391858.4_3'UTR	NM_001010984.2|NM_032018.5	NP_001010984.1|NP_114407.3			SprT-like N-terminal domain																		TTCTAAGATATCCCTAAGAAA	0.418000													25	77					0	0	0.639603	0	0
ZNF418	147686	broad.mit.edu	37	19	58438767	58438767	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:58438767C>A	ENST00000396147.1	-	4	1073	c.782G>T	c.(781-783)gGa>gTa	p.G261V	ZNF418_ENST00000599852.1_Missense_Mutation_p.G176V|ZNF418_ENST00000425570.3_Missense_Mutation_p.G282V|ZNF418_ENST00000595830.1_Missense_Mutation_p.G261V|ZNF418_ENST00000600989.1_Intron	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCCACATTCTCCACATTCATA	0.418000													15	210					1.3612e-06	1.51862e-06	0.479597	1	0
BTBD9	114781	broad.mit.edu	37	6	38256211	38256211	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:38256211C>A	ENST00000481247.1	-	8	1442	c.1291G>T	c.(1291-1293)Gct>Tct	p.A431S	BTBD9_ENST00000314100.6_Missense_Mutation_p.A363S|BTBD9_ENST00000403056.1_Missense_Mutation_p.A431S|BTBD9_ENST00000408958.1_Missense_Mutation_p.A363S|BTBD9_ENST00000419706.2_Missense_Mutation_p.A401S	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	431					cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						GCACAATCAGCAATTGTTGCA	0.428000													18	75					5.35267e-07	6.05405e-07	0.557998	1	0
RPS10P7	376693	broad.mit.edu	37	1	201489431	201489431	+	RNA	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:201489431C>A	ENST00000441932.1	+	0	1601				RP11-134G8.7_ENST00000454651.1_RNA	NR_026667.1																						TGATTACCTTCATCTGCCCTC	0.537000													6	16					3.59834e-05	3.93418e-05	0.217242	1	0
ALPK1	80216	broad.mit.edu	37	4	113359713	113359713	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:113359713G>C	ENST00000458497.1	+	13	3541	c.3262G>C	c.(3262-3264)Gca>Cca	p.A1088P	ALPK1_ENST00000177648.9_Missense_Mutation_p.A1088P|ALPK1_ENST00000504176.2_Missense_Mutation_p.A1010P	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1088	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ACAGATGACCGCACAGCACTA	0.428000													39	151					0	0	0.819951	0	0
DEPDC7	91614	broad.mit.edu	37	11	33054967	33054967	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:33054967A>T	ENST00000311388.3	+	9	1851	c.1475A>T	c.(1474-1476)cAc>cTc	p.H492L	DEPDC7_ENST00000241051.3_Missense_Mutation_p.H501L	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	501					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						TATAAGTGTCACCCAGACATC	0.299000													35	108					0	0	0.796494	0	0
MDC1	9656	broad.mit.edu	37	6	30680344	30680344	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:30680344C>T	ENST00000376406.3	-	5	2022	c.1375G>A	c.(1375-1377)Gag>Aag	p.E459K	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Missense_Mutation_p.E459K	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	459	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						AGCTCTTCCTCCTCCACGTCT	0.493000								Other conserved DNA damage response genes					35	133					0	0	0.796494	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890513	23890513	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:23890513T>A	ENST00000532292.1	-	1	662	c.568A>T	c.(568-570)Acc>Tcc	p.T190S		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		AACTGGGAGGTAGCTGGGAAG	0.582000													19	79					0	0	0.575678	0	0
SDC2	6383	broad.mit.edu	37	8	97614673	97614673	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:97614673C>T	ENST00000302190.4	+	3	1144	c.223C>T	c.(223-225)Cca>Tca	p.P75S	SDC2_ENST00000518385.1_Missense_Mutation_p.P39S|SDC2_ENST00000522911.1_Missense_Mutation_p.P46S|SDC2_ENST00000519914.1_Missense_Mutation_p.P46S	NM_002998.3	NP_002989.2	P34741	SDC2_HUMAN	syndecan 2	75						integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			breast(1)|cervix(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|stomach(2)	16	Breast(36;3.41e-05)				Sargramostim(DB00020)	TCGACCACTTCCAAAGATACT	0.448000													36	148					0	0	0.769981	0	0
CCL1	6346	broad.mit.edu	37	17	32688914	32688914	+	Splice_Site	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:32688914C>T	ENST00000225842.3	-	2	147	c.76_splice	c.e2-1	p.M26_splice		NM_002981.1	NP_002972.1	P22362	CCL1_HUMAN	chemokine (C-C motif) ligand 1	26					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity						Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		AGGGTACCTGCACTAGAAGAG	0.453000											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	130					0	0	0.819951	0	0
SLC43A3	29015	broad.mit.edu	37	11	57176684	57176684	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:57176684G>A	ENST00000395123.2	-	13	1639	c.1335C>T	c.(1333-1335)acC>acT	p.T445T	SLC43A3_ENST00000395124.1_Silent_p.T445T|SLC43A3_ENST00000352187.1_Silent_p.T445T|SLC43A3_ENST00000533524.1_Silent_p.T458T|SLC43A3_ENST00000529554.1_Silent_p.T445T|RP11-872D17.8_ENST00000529411.1_Silent_p.T89T	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	445					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						CTTTGATGAGGGTGAAGATGG	0.567000													45	168					0	0	0.853193	0	0
ARID2	196528	broad.mit.edu	37	12	46244170	46244170	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:46244170C>T	ENST00000334344.6	+	15	2436	c.2264C>T	c.(2263-2265)aCa>aTa	p.T755I	ARID2_ENST00000422737.1_Missense_Mutation_p.T606I|ARID2_ENST00000444670.1_Missense_Mutation_p.T365I|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	755					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CAACCTGTTACAGTTGTGAAT	0.478000			"""N, S, F"""		hepatocellular carcinoma								20	87					0	0	0.575678	0	0
OR52E4	390081	broad.mit.edu	37	11	5905705	5905705	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:5905705G>T	ENST00000316987.2	+	1	205	c.183G>T	c.(181-183)atG>atT	p.M61I		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCAGCCCATGTTCTACTTCC	0.433000													71	251					4.98926e-31	6.65235e-31	0.870114	1	0
KLHL28	54813	broad.mit.edu	37	14	45403630	45403630	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr14:45403630C>A	ENST00000396128.4	-	3	1150	c.1031G>T	c.(1030-1032)cGt>cTt	p.R344L	KLHL28_ENST00000355081.2_Missense_Mutation_p.R358L	NM_017658.3	NP_060128.2	Q9NXS3	KLH28_HUMAN	kelch-like family member 28	344								p.R344H(1)		breast(2)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GACGCCAGGACGCACATTAGT	0.393000													74	98					2.10328e-26	2.78176e-26	0.870114	1	0
IGSF9B	22997	broad.mit.edu	37	11	133815961	133815961	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:133815961T>A	ENST00000321016.8	-	2	487	c.257A>T	c.(256-258)tAt>tTt	p.Y86F	IGSF9B_ENST00000533871.2_Missense_Mutation_p.Y86F			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	86	Ig-like 1.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTTACCTGCATACTCAGGGTC	0.612000													4	9					0	0	0.184627	0	0
ZNF83	55769	broad.mit.edu	37	19	53116711	53116711	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:53116711A>G	ENST00000597597.1	-	2	3360	c.1107T>C	c.(1105-1107)ggT>ggC	p.G369G	ZNF83_ENST00000391789.4_Silent_p.G341G|ZNF83_ENST00000301096.3_Silent_p.G369G|ZNF83_ENST00000544146.1_Silent_p.G369G|ZNF83_ENST00000541777.2_Silent_p.G369G|ZNF83_ENST00000536937.1_Silent_p.G369G|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000545872.1_Silent_p.G369G|ZNF83_ENST00000601257.1_Intron			P51522	ZNF83_HUMAN	zinc finger protein 83	369						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		AAGGTTTCTCACCGGCATGAA	0.393000													57	199					0	0	0.870114	0	0
DPEP3	64180	broad.mit.edu	37	16	68012506	68012506	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:68012506G>A	ENST00000268793.4	-	3	886	c.513C>T	c.(511-513)tgC>tgT	p.C171C	DPEP3_ENST00000574342.1_5'UTR	NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	146					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		CCTGGGACTGGCATGAGACGG	0.612000													4	171					0	0	0.150653	0	0
IMMP2L	83943	broad.mit.edu	37	7	110303688	110303688	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:110303688C>A	ENST00000405709.2	-	6	940	c.498G>T	c.(496-498)gaG>gaT	p.E166D	IMMP2L_ENST00000452895.1_Missense_Mutation_p.E166D|IMMP2L_ENST00000450877.1_Missense_Mutation_p.E148D|IMMP2L_ENST00000331762.3_Missense_Mutation_p.E166D|IMMP2L_ENST00000415362.1_Missense_Mutation_p.E166D|IMMP2L_ENST00000489381.1_5'UTR	NM_032549.3	NP_115938.1	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	166					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity	p.E166E(1)		endometrium(3)|large_intestine(6)|lung(5)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CTGGTAAGCGCTCTGGAGGAA	0.493000													33	110					2.08457e-15	2.57044e-15	0.750413	1	0
NPHP3	27031	broad.mit.edu	37	3	132413714	132413714	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:132413714C>A	ENST00000337331.5	-	16	2353	c.2267G>T	c.(2266-2268)cGg>cTg	p.R756L	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	756					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CATGGACTCCCGGATAGAGTG	0.373000													31	157					8.88839e-20	1.13883e-19	0.750413	1	0
CHL1	10752	broad.mit.edu	37	3	384665	384665	+	Splice_Site	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:384665A>T	ENST00000256509.2	+	8	1321		c.e8-1		CHL1_ENST00000397491.2_Intron	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTTTTATTTCAGTAAAGCATG	0.328000													20	77					0	0	0.557998	0	0
BPHL	670	broad.mit.edu	37	6	3129325	3129325	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:3129325G>A	ENST00000380368.2	+	5	1018	c.374G>A	c.(373-375)gGc>gAc	p.G125D	BPHL_ENST00000380379.5_Missense_Mutation_p.G142D|BPHL_ENST00000434640.1_Missense_Mutation_p.G125D|BPHL_ENST00000380375.3_Missense_Mutation_p.G125D			Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like (serine hydrolase)	142					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity	p.G125D(1)		endometrium(4)|kidney(1)|large_intestine(2)|lung(6)	13	Ovarian(93;0.0386)	all_hematologic(90;0.108)				AGTGATGGGGGCATAACCGCA	0.488000													4	164					0	0	0.150653	0	0
EDC4	23644	broad.mit.edu	37	16	67911296	67911296	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:67911296A>T	ENST00000358933.5	+	5	867	c.628A>T	c.(628-630)Aat>Tat	p.N210Y	EDC4_ENST00000574770.1_3'UTR	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	210					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GGCTCTGGTTAATGGCAAAAT	0.567000													25	65					0	0	0.681144	0	0
PREX2	80243	broad.mit.edu	37	8	69028102	69028102	+	Silent	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:69028102T>C	ENST00000288368.4	+	26	3538	c.3261T>C	c.(3259-3261)ttT>ttC	p.F1087F		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1087					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GGGTATGTTTTAATGTAGCAG	0.383000													33	163					0	0	0.760397	0	0
MTR	4548	broad.mit.edu	37	1	237044136	237044136	+	Splice_Site	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:237044136G>A	ENST00000366577.5	+	25	3070	c.2676_splice	c.e25+1	p.V892_splice	MTR_ENST00000535889.1_Splice_Site_p.V841_splice	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	892	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GTGTGGTGGTGGTAAGTGGGT	0.408000													3	65					0	0	0.115264	0	0
C9orf135	138255	broad.mit.edu	37	9	72472845	72472845	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:72472845C>T	ENST00000377197.3	+	4	488	c.401C>T	c.(400-402)aCa>aTa	p.T134I	C9orf135_ENST00000466872.2_3'UTR|C9orf135_ENST00000527647.1_Missense_Mutation_p.T134I	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135	134						integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						TTGCCTGCCACAGGTTTTGGA	0.368000													71	129					0	0	0.870114	0	0
BCL9L	283149	broad.mit.edu	37	11	118779003	118779003	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:118779003G>A	ENST00000334801.3	-	2	1352	c.388C>T	c.(388-390)Cca>Tca	p.P130S	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	130					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCCAGGGATGGGGTCCCAGCC	0.592000													21	98					0	0	0.575678	0	0
ISL1	3670	broad.mit.edu	37	5	50687247	50687247	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:50687247A>T	ENST00000230658.7	+	5	1490	c.905A>T	c.(904-906)gAc>gTc	p.D302V	ISL1_ENST00000511384.1_Missense_Mutation_p.D279V|ISL1_ENST00000505475.2_3'UTR	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	302	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				TTGCAGAGTGACATAGATCAG	0.498000													25	77					0	0	0.706142	0	0
SNHG14	104472715	broad.mit.edu	37	15	25296663	25296663	+	RNA	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:25296663A>G	ENST00000549804.2	+	0	98				SNHG14_ENST00000547292.1_RNA|SNORD116-1_ENST00000384335.1_RNA|SNHG14_ENST00000552781.1_RNA																							TTCCTTGGAAAAGCTGAACAA	0.488000													44	168					0	0	0.864702	0	0
NPHP4	261734	broad.mit.edu	37	1	6038470	6038470	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:6038470C>T	ENST00000378156.4	-	3	404	c.139G>A	c.(139-141)Gtg>Atg	p.V47M	NPHP4_ENST00000478423.2_Intron	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	47					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTCCAGCACGCCCTAGGAG	0.557000													3	16					0	0	0.115264	0	0
STEAP3	55240	broad.mit.edu	37	2	120003448	120003448	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:120003448C>T	ENST00000354888.5	+	3	880	c.376C>T	c.(376-378)Cgt>Tgt	p.R126C	STEAP3_ENST00000450943.2_Missense_Mutation_p.R126C|STEAP3_ENST00000393108.2_Missense_Mutation_p.R126C|STEAP3-AS1_ENST00000454260.1_RNA|STEAP3_ENST00000393110.2_Missense_Mutation_p.R136C|STEAP3_ENST00000425223.2_Missense_Mutation_p.R126C|STEAP3_ENST00000409811.1_Missense_Mutation_p.R126C|STEAP3_ENST00000393106.2_Missense_Mutation_p.R126C|STEAP3_ENST00000393107.2_Missense_Mutation_p.R126C	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	126					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						CCTTCAGCATCGTGAGTCCAA	0.582000													7	136					0	0	0.248553	0	0
SERPINI1	5274	broad.mit.edu	37	3	167525118	167525118	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:167525118C>A	ENST00000295777.5	+	6	1399	c.968C>A	c.(967-969)aCa>aAa	p.T323K	SERPINI1_ENST00000488374.1_3'UTR|SERPINI1_ENST00000446050.2_Missense_Mutation_p.T323K	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	323					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						GCAAATTTGACAGGCCTCTCT	0.303000													26	129					1.85244e-09	2.17e-09	0.654019	1	0
NALCN	259232	broad.mit.edu	37	13	101763549	101763549	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr13:101763549C>T	ENST00000251127.6	-	19	2302	c.2221G>A	c.(2221-2223)Gga>Aga	p.G741R		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	741						integral to membrane	sodium channel activity|voltage-gated ion channel activity	p.G741R(1)		NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCAAATGATCCGCTCAGCATG	0.493000													69	201					0	0	0.870114	0	0
BICC1	80114	broad.mit.edu	37	10	60546842	60546842	+	Splice_Site	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:60546842G>C	ENST00000373886.3	+	5	550		c.e5+1			NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)						multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						AAGCAACCAGGTGGTTTGTCT	0.353000													5	72					0	0	0.184627	0	0
NOTCH1	4851	broad.mit.edu	37	9	139401756	139401756	+	Splice_Site	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:139401756C>T	ENST00000277541.6	-	22	3719		c.e22+1			NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.?(4)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGGCCCTTACCCTGAGTGCC	0.692000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			24	49					0	0	0.667858	0	0
CDH9	1007	broad.mit.edu	37	5	26988326	26988326	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:26988326C>G	ENST00000231021.4	-	2	287	c.115G>C	c.(115-117)Ggt>Cgt	p.G39R		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	39					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTTGTCAGACCCGCTATCTTT	0.393000													32	73					0	0	0.740014	0	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:115080343G>T	ENST00000537058.1	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000537140.1_Intron|CADM1_ENST00000331581.6_Silent_p.T343T|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000452722.2_Silent_p.T343T			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	343				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													6	81					0.0215528	0.0228042	0.217242	1	0
LRIG3	121227	broad.mit.edu	37	12	59274631	59274631	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:59274631T>C	ENST00000320743.3	-	13	1819	c.1533A>G	c.(1531-1533)atA>atG	p.I511M	LRIG3_ENST00000379141.4_Missense_Mutation_p.I451M	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	511	Ig-like C2-type 1.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TGGAACCTTTTATTGCCGACT	0.433000			T	ROS1	NSCLC								69	196					0	0	0.870114	0	0
ABCA13	154664	broad.mit.edu	37	7	48413965	48413965	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:48413965T>G	ENST00000435803.1	+	34	11179	c.11155T>G	c.(11155-11157)Ttt>Gtt	p.F3719V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3719					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GACAACCGCCTTTGGACAAGG	0.413000													5	19					0	0	0.248553	0	0
TTK	7272	broad.mit.edu	37	6	80720550	80720550	+	Silent	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:80720550A>G	ENST00000509894.1	+	5	1318	c.489A>G	c.(487-489)aaA>aaG	p.K163K	TTK_ENST00000230510.3_Silent_p.K163K|TTK_ENST00000369798.2_Silent_p.K163K			P33981	TTK_HUMAN	TTK protein kinase	163					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AAAAAAGTAAACAACTTCTTC	0.398000													21	51					0	0	0.608945	0	0
MICAL1	64780	broad.mit.edu	37	6	109773738	109773738	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:109773738C>T	ENST00000368952.4	-	5	999	c.709G>A	c.(709-711)Gca>Aca	p.A237T	MICAL1_ENST00000358577.3_Missense_Mutation_p.A218T|MICAL1_ENST00000358807.3_Missense_Mutation_p.A218T			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	218					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TTACCTCCTGCAGCCGAGATA	0.557000													15	43					0	0	0.539581	0	0
DMBT1	1755	broad.mit.edu	37	10	124399561	124399561	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:124399561C>A	ENST00000368909.3	+	52	6667	c.6561C>A	c.(6559-6561)gaC>gaA	p.D2187E	DMBT1_ENST00000368956.2_Missense_Mutation_p.D1559E|DMBT1_ENST00000338354.3_Missense_Mutation_p.D2187E|DMBT1_ENST00000368955.3_Missense_Mutation_p.D2177E|DMBT1_ENST00000344338.3_Missense_Mutation_p.D2177E|DMBT1_ENST00000359586.6_Missense_Mutation_p.D907E|DMBT1_ENST00000330163.4_Missense_Mutation_p.D1559E	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2187	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCTAGGCAGACAATGACACCA	0.527000													3	75					0.004672	0.00497538	0.115264	1	0
SPATA16	83893	broad.mit.edu	37	3	172835423	172835423	+	Silent	SNP	G	G	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:172835423G>C	ENST00000351008.3	-	2	282	c.99C>G	c.(97-99)acC>acG	p.T33T		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	33					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GGTGCGCTAAGGTGGACATTT	0.403000													207	423					0	0	0.870114	0	0
LPCAT2	54947	broad.mit.edu	37	16	55583314	55583314	+	Splice_Site	SNP	A	A	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:55583314A>G	ENST00000262134.5	+	10	1245	c.1061_splice	c.e10+1	p.K354_splice		NM_017839.4	NP_060309.2	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	354					cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	12						CGAAAATTGAAGTAAGTGTAT	0.363000													26	99					0	0	0.667858	0	0
A2M	2	broad.mit.edu	37	12	9256907	9256907	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:9256907G>A	ENST00000318602.7	-	11	1501	c.1194C>T	c.(1192-1194)acC>acT	p.T398T		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	398					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTCATCCGTGGTAGCATTGG	0.413000													8	31					0	0	0.278610	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													4	100					0	0	0.150653	0	0
ZNF236	7776	broad.mit.edu	37	18	74671751	74671751	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:74671751C>G	ENST00000253159.8	+	29	5413	c.5215C>G	c.(5215-5217)Cgc>Ggc	p.R1739G	ZNF236_ENST00000320610.9_Missense_Mutation_p.R1741G	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1739					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCAGCTGGAGCGCCACAGCCG	0.502000													14	65					0	0	0.479597	0	0
ATP10B	23120	broad.mit.edu	37	5	159992486	159992486	+	Silent	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:159992486G>T	ENST00000327245.5	-	26	5206	c.4360C>A	c.(4360-4362)Cga>Aga	p.R1454R		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1454					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCTGGGATCGGCGATGGCTG	0.527000													37	100					1.42033e-22	1.83413e-22	0.796494	1	0
TPD52L3	89882	broad.mit.edu	37	9	6330998	6330998	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:6330998G>A	ENST00000314556.3	+	2	582	c.390G>A	c.(388-390)acG>acA	p.T130T		NM_001001874.2	NP_001001874.1	Q96J77	TPD55_HUMAN	tumor protein D52-like 3	0							protein binding	p.T130T(2)		large_intestine(1)|lung(9)|skin(1)	11		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		ATAAATACACGTTAAATCAAG	0.313000													23	118					0	0	0.667858	0	0
FIGN	55137	broad.mit.edu	37	2	164467772	164467772	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:164467772G>A	ENST00000333129.3	-	3	884	c.570C>T	c.(568-570)aaC>aaT	p.N190N	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	190						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						AATATGATCCGTTGTATCCTG	0.502000													8	69					0	0	0.335167	0	0
PLSCR2	57047	broad.mit.edu	37	3	146171942	146171942	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:146171942G>A	ENST00000497985.1	-	7	988	c.549C>T	c.(547-549)atC>atT	p.I183I	PLSCR2_ENST00000336685.2_Silent_p.I110I	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	110					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						GAGGAGCTTGGATTTCTATCT	0.328000													14	56					0	0	0.435327	0	0
NADSYN1	55191	broad.mit.edu	37	11	71185480	71185480	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:71185480G>T	ENST00000319023.2	+	9	894	c.706G>T	c.(706-708)Gac>Tac	p.D236Y		NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	236	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAGGGTTGTGACGGGGACCG	0.557000													18	132					5.45727e-16	6.78024e-16	0.729181	1	0
ZNF423	23090	broad.mit.edu	37	16	49671562	49671562	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:49671562C>T	ENST00000561648.1	-	4	1554	c.1501G>A	c.(1501-1503)Gtc>Atc	p.V501I	ZNF423_ENST00000563137.2_Missense_Mutation_p.V441I|ZNF423_ENST00000262383.2_Missense_Mutation_p.V501I|ZNF423_ENST00000562871.1_Missense_Mutation_p.V441I|ZNF423_ENST00000562520.1_Missense_Mutation_p.V441I|ZNF423_ENST00000535559.1_Missense_Mutation_p.V384I|ZNF423_ENST00000567169.1_Missense_Mutation_p.V384I	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	501					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.V501I(2)		breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CAGTGGGAGACGCGGATGTGC	0.562000													6	75					0	0	0.248553	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072997	17072997	+	Silent	SNP	G	G	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:17072997G>A	ENST00000359963.3	-	1	703	c.444C>T	c.(442-444)ccC>ccT	p.P148P		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	148					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGCCAGGGAGGGCAGTGTGG	0.637000													8	48					0	0	0.307466	0	0
ADC	113451	broad.mit.edu	37	1	33583674	33583675	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:33583674_33583675insC	ENST00000294517.6	+	11	1788_1789	c.1201_1202insC	c.(1201-1203)ccafs	p.P401fs	ADC_ENST00000398167.1_Frame_Shift_Ins_p.P421fs|ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373443.3_Frame_Shift_Ins_p.P401fs|ADC_ENST00000373441.1_Frame_Shift_Ins_p.P421fs	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	401					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CTTTTGGGGGACCCAGGCCTGC	0.624													11	74	---	---	---	---					
COL24A1	255631	broad.mit.edu	37	1	86591796	86591796	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:86591796delC	ENST00000370571.2	-	3	589	c.223delG	c.(223-225)tcfs	p.V75fs	COL24A1_ENST00000436319.1_Frame_Shift_Del_p.V75fs	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	75	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTTAAATGGACCCCCTGAGGT	0.428													7	101	---	---	---	---					
PRG4	10216	broad.mit.edu	37	1	186276284	186276286	+	In_Frame_Del	DEL	CTC	CTC	-	rs145095882	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:186276284_186276286delCTC	ENST00000445192.2	+	7	1478_1480	c.1433_1435delCTC	c.(1432-1437)acc>a	p.TP478del	PRG4_ENST00000367486.3_In_Frame_Del_p.TP435del|PRG4_ENST00000367483.4_In_Frame_Del_p.TP437del|PRG4_ENST00000367485.4_In_Frame_Del_p.TP385del|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	478	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.P479delP(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						GCACCCACCACTCCCAAAGAGCC	0.650													11	97	---	---	---	---					
NR4A2	4929	broad.mit.edu	37	2	157182714	157182715	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:157182714_157182715insA	ENST00000339562.4	-	7	1849_1850	c.1487_1488insT	c.(1486-1488)aaafs	p.K496fs	NR4A2_ENST00000409572.1_Frame_Shift_Ins_p.K496fs|NR4A2_ENST00000539077.1_Frame_Shift_Ins_p.K507fs|NR4A2_ENST00000409108.2_Frame_Shift_Ins_p.*T461fs|NR4A2_ENST00000426264.1_Frame_Shift_Ins_p.K433fs|NR4A2_ENST00000429376.1_Frame_Shift_Ins_p.*T398fs	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	496					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						TGTCGATGTTCATATTCTGCAA	0.515													22	71	---	---	---	---					
SLC51A	200931	broad.mit.edu	37	3	195955100	195955102	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:195955100_195955102delCTG	ENST00000296327.5	+	5	686_688	c.477_479delCTG	c.(475-480)ccc>cc	p.PC159del		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		ACACAGGCCCctgctgctgctgc	0.665													9	248	---	---	---	---					
RP11-6N13.1	0	broad.mit.edu	37	5	103978776	103978779	+	RNA	DEL	GAAG	GAAG	-	rs60977525		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:103978776_103978779delGAAG	ENST00000503650.1	-	0	328																											agagagaaaagaaggaaggaagga	0.348													3	4	---	---	---	---					
TRBV7-1	28597	broad.mit.edu	37	7	142032162	142032163	+	RNA	DEL	GA	GA	-			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:142032162_142032163delGA	ENST00000547918.2	+	0	82																											atgtgtgtgtgAGAGAGAGAGA	0.505													4	9	---	---	---	---					
FABP5P3	220832	broad.mit.edu	37	7	152140120	152140121	+	RNA	INS	-	-	T	rs112177366		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:152140120_152140121insT	ENST00000477993.1	+	0	875_876					NR_002935.1																						CTGTTTCTTTCTTTTTTTTTTC	0.327													3	3	---	---	---	---					
RUNX1T1	862	broad.mit.edu	37	8	93017415	93017415	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:93017415delG	ENST00000523629.1	-	6	1123	c.669delC	c.(667-669)acfs	p.T224fs	RUNX1T1_ENST00000518844.1_Frame_Shift_Del_p.T197fs|RUNX1T1_ENST00000396218.1_Frame_Shift_Del_p.T197fs|RUNX1T1_ENST00000436581.2_Frame_Shift_Del_p.T235fs|RUNX1T1_ENST00000422361.2_Frame_Shift_Del_p.T187fs|RUNX1T1_ENST00000265814.3_Frame_Shift_Del_p.T224fs|RUNX1T1_ENST00000360348.2_Frame_Shift_Del_p.T187fs|RUNX1T1_ENST00000521553.1_Frame_Shift_Del_p.T187fs|RUNX1T1_ENST00000520724.1_Frame_Shift_Del_p.T187fs	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	224					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.T223T(1)|p.T186T(1)|p.T234T(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGGTGAGGTGGTGCTGGCAT	0.592													41	197	---	---	---	---					
LURAP1L	286343	broad.mit.edu	37	9	12775861	12775862	+	In_Frame_Ins	INS	-	-	GGCGGC	rs3833707	by1000genomes	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:12775861_12775862insGGCGGC	ENST00000319264.3	+	1	842_843	c.147_148insGGCGGC	c.(145-150)gggcgg>ggGGCGGCgcgg	p.49_50GR>GAAR	RP11-3L8.3_ENST00000417638.1_RNA|LURAP1L_ENST00000489107.1_3'UTR	NM_203403.1	NP_981948.1	Q8IV03	CI150_HUMAN	leucine rich adaptor protein 1-like	49	Gly-rich.		Missing.					p.G49_G50insGGG(2)|p.G50_G52delGGG(1)									gcggtggtggtggcggcggcgg	0.688													3	4	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651228	+	In_Frame_Del	DEL	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	-	rs35089393	by1000genomes	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:1651199_1651228delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	ENST00000399676.2	+	1	167_196	c.129_158delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	c.(127-159)ggg>gg	p.GGCGGCGSGCA43del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtgggggctgtggctccggctgtgcgggctgtggg	0.691													52	8	---	---	---	---					
USP35	57558	broad.mit.edu	37	11	77921387	77921388	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:77921387_77921388insC	ENST00000529308.1	+	10	2747_2748	c.2486_2487insC	c.(2485-2487)accfs	p.T829fs	USP35_ENST00000530267.1_Frame_Shift_Ins_p.T397fs|USP35_ENST00000526425.1_Frame_Shift_Ins_p.T560fs|USP35_ENST00000441408.2_Frame_Shift_Ins_p.T415fs|USP35_ENST00000530535.1_3'UTR	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	829					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GACGTCTCCATCCCCCTGCTGC	0.634													18	170	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	AGC	-	rs141441894	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:43969653_43969655delAGC	ENST00000244333.3	-	1	157_159	c.69_71delGCT	c.(67-72)ctt>ct	p.LL23del		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	23						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													7	226	---	---	---	---					
LILRB4	11006	broad.mit.edu	37	19	55179246	55179246	+	Splice_Site	DEL	T	T	-	rs139028841	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:55179246delT	ENST00000391736.1	+	13	1515		c.e13+2		LILRB4_ENST00000270452.2_Splice_Site|LILRB4_ENST00000391733.3_Splice_Site|LILRB4_ENST00000391734.3_Intron|LILRB4_ENST00000430952.2_Splice_Site	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4							integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GACACTGAGGTGAGTCCTTTC	0.617													15	90	---	---	---	---					
RPL23AP79	100271626	broad.mit.edu	37	19	59091278	59091279	+	RNA	INS	-	-	TTCC	rs10674364		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:59091278_59091279insTTCC	ENST00000493504.1	+	0	129					NR_026052.1																						CTCTATTttctttccttccttc	0.446													3	5	---	---	---	---					
ZBTB21	49854	broad.mit.edu	37	21	43413874	43413875	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr21:43413874_43413875insC	ENST00000310826.5	-	3	513_514	c.330_331insG	c.(328-333)ggtttcfs	p.GF110fs	ZBTB21_ENST00000398505.3_Frame_Shift_Ins_p.GF110fs|ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398511.3_Frame_Shift_Ins_p.GF110fs|ZBTB21_ENST00000398499.1_Frame_Shift_Ins_p.GF110fs	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		AGAAAGGAAATCCCAAGACTAT	0.376													16	50	---	---	---	---					
SLITRK4	139065	broad.mit.edu	37	X	142718162	142718163	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chrX:142718162_142718163insT	ENST00000381779.4	-	2	987_988	c.762_763insA	c.(760-765)aaaaacfs	p.N255fs	SLITRK4_ENST00000338017.4_Frame_Shift_Ins_p.N255fs|SLITRK4_ENST00000356928.1_Frame_Shift_Ins_p.N255fs	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	255	LRRCT 1.					integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTTGGTTTCTTTTAAAAGCC	0.450													19	47	---	---	---	---