Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LTBP1	4052	broad.mit.edu	37	2	33567941	33567941	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:33567941G>A	ENST00000404816.2	+	25	4120	c.3767G>A	c.(3766-3768)aGt>aAt	p.S1256N	LTBP1_ENST00000354476.3_Missense_Mutation_p.S1257N|LTBP1_ENST00000390003.4_Missense_Mutation_p.S931N|LTBP1_ENST00000404525.1_Missense_Mutation_p.S877N|LTBP1_ENST00000402934.1_Missense_Mutation_p.S877N|LTBP1_ENST00000418533.2_Intron|LTBP1_ENST00000272273.5_Intron|LTBP1_ENST00000407925.1_Missense_Mutation_p.S930N			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1256	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTTTGTGACAGTCACGGGTTT	0.443000													7	50					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129642399	129642399	+	Missense_Mutation	SNP	A	A	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:129642399A>C	ENST00000319119.4	+	2	806	c.721A>C	c.(721-723)Aag>Cag	p.K241Q	ZBTB34_ENST00000373452.2_Missense_Mutation_p.K237Q	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						GGTGAAAGTGAAGATGGAGAA	0.547000													6	67					0	0	1	0	0
GDI2	2665	broad.mit.edu	37	10	5827219	5827219	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr10:5827219C>T	ENST00000380191.4	-	6	895	c.605G>A	c.(604-606)tGt>tAt	p.C202Y	GDI2_ENST00000380181.3_Missense_Mutation_p.C157Y|GDI2_ENST00000380132.4_Missense_Mutation_p.C206Y	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2	202					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						GGTTTCATAACACGGTTGATC	0.348000													6	87					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135481	156135481	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:156135481G>T	ENST00000329476.3	+	2	879	c.390G>T	c.(388-390)caG>caT	p.Q130H	NPY2R_ENST00000506608.1_Missense_Mutation_p.Q130H	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	130					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CCTATGCCCAGGGCCTGGCAG	0.522000													8	56					0.0381472	0.0430023	1	1	0
CCDC148	130940	broad.mit.edu	37	2	159170404	159170404	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:159170404T>C	ENST00000283233.5	-	8	1080	c.767A>G	c.(766-768)aAc>aGc	p.N256S	CCDC148_ENST00000409187.1_Missense_Mutation_p.N265S|CCDC148_ENST00000536771.1_Missense_Mutation_p.N170S	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	256										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TAGTTGACAGTTTCTAGAAGC	0.388000													4	55					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135277018	135277018	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:135277018G>A	ENST00000334270.2	-	2	1230	c.1191C>T	c.(1189-1191)gtC>gtT	p.V397V		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	397					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GTGCCCTTTTGACAGACGTAA	0.463000													8	100					0	0	1	0	0
ANKRD39	51239	broad.mit.edu	37	2	97514153	97514153	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:97514153C>T	ENST00000393537.4	-	4	544	c.437G>A	c.(436-438)tGc>tAc	p.C146Y		NM_016466.5	NP_057550.3	Q53RE8	ANR39_HUMAN	ankyrin repeat domain 39	146										NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	6						GAGGAGGGAGCAGATGTCCCC	0.607000													8	49					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42525788	42525788	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr22:42525788G>A	ENST00000360608.5	-	2	418	c.304C>T	c.(304-306)Ccg>Tcg	p.P102S	CYP2D6_ENST00000389970.3_Missense_Mutation_p.P102S|CYP2D6_ENST00000359033.4_Missense_Mutation_p.P102S|NDUFA6-AS1_ENST00000439129.1_RNA|NDUFA6-AS1_ENST00000416037.1_RNA	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	102							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GGCACAGGCGGGCGGTCGGCG	0.697000													3	29					0	0	1	0	0
ETAA1	54465	broad.mit.edu	37	2	67626364	67626364	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:67626364C>G	ENST00000272342.5	+	2	417	c.287C>G	c.(286-288)cCt>cGt	p.P96R		NM_019002.3	NP_061875.2	Q9NY74	ETAA1_HUMAN	Ewing tumor-associated antigen 1	96						cytoplasm|nucleus				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	33						TTCAGTTCTCCTAATGATCCA	0.318000													5	40					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2984095	2984095	+	Silent	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr7:2984095C>T	ENST00000396946.4	-	5	838	c.435G>A	c.(433-435)aaG>aaA	p.K145K	AC004906.3_ENST00000423194.1_RNA	NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	145					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GTTGCAGGTCCTTGGCCTTCA	0.617000			Mis		DLBCL								7	72					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371373	240371373	+	Silent	SNP	A	A	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:240371373A>T	ENST00000319653.9	+	5	3491	c.3261A>T	c.(3259-3261)ccA>ccT	p.P1087P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1087	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCATACCCCCACCTCCCCCTC	0.726000													3	9					0	0	1	0	0
EPSTI1	94240	broad.mit.edu	37	13	43500540	43500540	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr13:43500540G>T	ENST00000313640.7	-	7	653	c.589C>A	c.(589-591)Ctg>Atg	p.L197M	EPSTI1_ENST00000313624.7_Missense_Mutation_p.L197M|EPSTI1_ENST00000476830.2_5'UTR|EPSTI1_ENST00000398762.3_Missense_Mutation_p.L197M	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	197										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TCTGTGTTCAGTTTGCTCAAG	0.428000													8	132					1.12685e-05	1.42581e-05	1	1	0
GABRA2	2555	broad.mit.edu	37	4	46307679	46307679	+	Silent	SNP	A	A	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:46307679A>G	ENST00000510861.1	-	7	782	c.609T>C	c.(607-609)tcT>tcC	p.S203S	GABRA2_ENST00000356504.1_Silent_p.S203S|GABRA2_ENST00000507069.1_Silent_p.S203S|GABRA2_ENST00000540012.1_Silent_p.S148S|GABRA2_ENST00000381620.4_Silent_p.S203S|GABRA2_ENST00000514090.1_Silent_p.S203S|GABRA2_ENST00000515082.1_Silent_p.S203S			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	203					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTACTGAATCAGATGCATTGT	0.358000													4	49					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36985988	36985988	+	Silent	SNP	A	A	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:36985988A>G	ENST00000282516.8	+	10	3205	c.2706A>G	c.(2704-2706)aaA>aaG	p.K902K	NIPBL_ENST00000448238.2_Silent_p.K902K|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	902					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ATTCTAATAAATCAAGATCTG	0.393000													5	52					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72159281	72159281	+	Silent	SNP	T	T	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:72159281T>G	ENST00000537465.1	-	16	2450	c.2292A>C	c.(2290-2292)acA>acC	p.T764T	PMFBP1_ENST00000355636.6_Silent_p.T614T|PMFBP1_ENST00000237353.10_Silent_p.T759T			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	764										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				GCAGGCTCTTTGTCTCTGAGG	0.483000											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	181					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99662274	99662274	+	Nonstop_Mutation	SNP	A	A	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr7:99662274A>C	ENST00000543588.1	+	6	1597	c.1353A>C	c.(1351-1353)taA>taC	p.*451Y	ZSCAN21_ENST00000292450.4_3'UTR|ZSCAN21_ENST00000456748.2_Nonstop_Mutation_p.*451Y|ZNF3_ENST00000413658.2_3'UTR			Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	0					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CGTTGTTTTAAACTTTAGAAT	0.453000													3	43					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71739939	71739939	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:71739939C>T	ENST00000318442.5	-	5	2369	c.1879G>A	c.(1879-1881)Gag>Aag	p.E627K		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGCTCCACCTCGTAGCAGTTA	0.667000													7	120					0	0	1	0	0
CWF19L2	143884	broad.mit.edu	37	11	107207333	107207333	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:107207333C>A	ENST00000282251.5	-	15	2336	c.2309G>T	c.(2308-2310)tGt>tTt	p.C770F		NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	770							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		AAGAGGAATACATTCATAAAC	0.328000													4	23					0.00024832	0.000296074	1	1	0
LGR5	8549	broad.mit.edu	37	12	71833921	71833921	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:71833921G>T	ENST00000266674.5	+	1	372	c.61G>T	c.(61-63)Ggg>Tgg	p.G21W	TSPAN8_ENST00000393330.2_Intron|LGR5_ENST00000536515.1_Missense_Mutation_p.G21W|LGR5_ENST00000540815.2_Missense_Mutation_p.G21W			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	21						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GCTGGCGACCGGGGGCAGCTC	0.682000													3	43					0.115264	0.119106	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76556036	76556036	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:76556036G>A	ENST00000307431.8	+	18	3019	c.2634G>A	c.(2632-2634)gtG>gtA	p.V878V	CNTNAP4_ENST00000478060.1_Silent_p.V806V|CNTNAP4_ENST00000476707.1_Silent_p.V882V|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Silent_p.V830V	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	879	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GGCACCATGTGAGGGTTGAAA	0.527000													11	102					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182956	140182956	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:140182956C>A	ENST00000522353.2	+	1	2174	c.2174C>A	c.(2173-2175)gCg>gAg	p.A725E	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.A725E|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGCTCCGCGCCGCCAACC	0.637000													7	104					0.0381472	0.0430023	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62287901	62287901	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:62287901G>A	ENST00000378024.4	-	5	14262	c.13988C>T	c.(13987-13989)cCt>cTt	p.P4663L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4663					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTGAAGCCAGGCATGCTGAA	0.512000													9	322					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													3	29					0	0	1	0	0
TAS2R30	259293	broad.mit.edu	37	12	11286073	11286073	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:11286073C>A	ENST00000539585.1	-	1	1170	c.771G>T	c.(769-771)aaG>aaT	p.K257N	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_001097643.1	NP_001091112.1			taste receptor, type 2, member 30											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						AGACAGGTTGCTTTTCCAGCC	0.388000													7	133					0.00198382	0.00232069	1	1	0
WDR82	80335	broad.mit.edu	37	3	52304734	52304734	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:52304734T>C	ENST00000296490.3	-	2	534	c.253A>G	c.(253-255)Ata>Gta	p.I85V		NM_025222.3	NP_079498.2	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	85					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding								BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TTACCGTCTATTTTGTTAGAG	0.378000													14	128					0	0	1	0	0
RNF6	6049	broad.mit.edu	37	13	26788214	26788214	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr13:26788214C>A	ENST00000381588.4	-	5	2557	c.1805G>T	c.(1804-1806)cGa>cTa	p.R602L	RNF6_ENST00000399762.2_Missense_Mutation_p.R246L|RNF6_ENST00000468480.1_Intron|RNF6_ENST00000381570.3_Missense_Mutation_p.R602L|RNF6_ENST00000346166.3_Missense_Mutation_p.R602L	NM_005977.3	NP_005968.1	Q9Y252	RNF6_HUMAN	ring finger protein (C3H2C3 type) 6	602					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(3)|ovary(2)|prostate(2)|skin(2)	23	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		ACCACGTATTCGATCATCATC	0.373000													8	107					1.12685e-05	1.42581e-05	1	1	0
FLG	2312	broad.mit.edu	37	1	152280000	152280000	+	Silent	SNP	C	C	T	rs144122917		TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:152280000C>T	ENST00000368799.1	-	3	7397	c.7362G>A	c.(7360-7362)acG>acA	p.T2454T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2454	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCTTGGGACGTTGAGTGCC	0.577000									Ichthyosis				13	397					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15587145	15587145	+	Silent	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr19:15587145C>T	ENST00000292609.4	-	2	465	c.336G>A	c.(334-336)ctG>ctA	p.L112L	PGLYRP2_ENST00000340880.4_Silent_p.L112L			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	112					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CATCAGGTGCCAGCACCACCC	0.617000													11	91					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373569	86373569	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:86373569A>G	ENST00000604798.1	-	8	2139	c.935T>C	c.(934-936)aTg>aCg	p.M312T	MGAT4C_ENST00000393205.2_Missense_Mutation_p.M341T|MGAT4C_ENST00000332156.1_Missense_Mutation_p.M312T|MGAT4C_ENST00000548651.1_Missense_Mutation_p.M312T|MGAT4C_ENST00000552435.2_Silent_p.H100H|MGAT4C_ENST00000552808.2_Missense_Mutation_p.M312T|MGAT4C_ENST00000549405.2_Missense_Mutation_p.M312T			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	312					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						ATAATAGCCCATGTGCTGAAA	0.408000													10	69					0	0	1	0	0
KPNA4	3840	broad.mit.edu	37	3	160227623	160227623	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:160227623T>A	ENST00000334256.4	-	14	1479	c.1174A>T	c.(1174-1176)Ata>Tta	p.I392L		NM_002268.4	NP_002259.1	O00629	IMA4_HUMAN	karyopherin alpha 4 (importin alpha 3)	392	NLS binding site (minor) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)	22			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AAGTTACTTATGGCCCAAGCA	0.318000													24	115					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1272370	1272370	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:1272370G>A	ENST00000310581.5	-	7	2369	c.2312C>T	c.(2311-2313)cCg>cTg	p.P771L	TERT_ENST00000508104.2_Intron|TERT_ENST00000334602.6_Missense_Mutation_p.P771L|TERT_ENST00000296820.5_Intron	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	771	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCGCATGTACGGCTGGAGGTC	0.632000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				3	12					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13814775	13814775	+	Missense_Mutation	SNP	A	A	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:13814775A>C	ENST00000265104.4	-	43	7273	c.7169T>G	c.(7168-7170)gTc>gGc	p.V2390G		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2390	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					atttcttgagacggtggcagg	0.393000									Kartagener syndrome				6	64					0	0	1	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													3	19					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30100144	30100144	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:30100144G>A	ENST00000331968.5	-	10	1705	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	PRKD1_ENST00000415220.2_Silent_p.F500F	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	492	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TAGTGATTTCGAAACAATGAG	0.398000													17	75					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141591969	141591969	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:141591969G>C	ENST00000442267.2	-	7	1245	c.1171C>G	c.(1171-1173)Cta>Gta	p.L391V		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	391						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CTCTGCACTAGAAAGTCTCTA	0.453000													5	86					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71009773	71009773	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr6:71009773T>C	ENST00000357250.6	-	4	430	c.272A>G	c.(271-273)aAt>aGt	p.N91S	COL9A1_ENST00000370496.3_Missense_Mutation_p.N91S	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	91	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GTCTACATTATTTCCCAACTT	0.363000													7	43					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52643860	52643860	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:52643860C>T	ENST00000356770.4	-	15	1942	c.1940G>A	c.(1939-1941)cGc>cAc	p.R647H	PBRM1_ENST00000394830.3_Missense_Mutation_p.R679H|PBRM1_ENST00000337303.4_Missense_Mutation_p.R679H|PBRM1_ENST00000409767.1_Missense_Mutation_p.R694H|PBRM1_ENST00000409114.3_Missense_Mutation_p.R694H|PBRM1_ENST00000409057.1_Missense_Mutation_p.R679H|PBRM1_ENST00000296302.7_Missense_Mutation_p.R679H|PBRM1_ENST00000410007.1_Missense_Mutation_p.R679H			Q86U86	PB1_HUMAN	polybromo 1	679					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.R678_R679delRR(2)|p.R646_R647delRR(1)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGCACTGAGGCGGCGACCCCT	0.413000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								12	87					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4218155	4218155	+	Missense_Mutation	SNP	G	G	A	rs141831391	byFrequency	TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr7:4218155G>A	ENST00000404826.2	+	35	5174	c.5035G>A	c.(5035-5037)Gcc>Acc	p.A1679T	SDK1_ENST00000389531.3_Missense_Mutation_p.A1659T	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1679	Fibronectin type-III 10.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AATAATGACCGCCTATAACAT	0.547000													6	121					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186760908	186760908	+	Silent	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:186760908C>T	ENST00000169298.3	+	4	1091	c.417C>T	c.(415-417)gcC>gcT	p.A139A	ST6GAL1_ENST00000457772.2_Intron|ST6GAL1_ENST00000448044.1_Silent_p.A139A	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	139					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTGCAGAGGCCCTGCGCTGCC	0.507000													6	47					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157804318	157804318	+	Missense_Mutation	SNP	T	T	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:157804318T>G	ENST00000368174.4	-	4	693	c.597A>C	c.(595-597)aaA>aaC	p.K199N		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	199	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity	p.K199K(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCCAGATGGGTTTTCGGCCAT	0.582000													6	49					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3139681	3139681	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:3139681G>A	ENST00000446632.2	-	7	1156	c.582C>T	c.(580-582)atC>atT	p.I194I	IL5RA_ENST00000311981.8_Silent_p.I194I|IL5RA_ENST00000456302.1_Silent_p.I194I|IL5RA_ENST00000256452.3_Silent_p.I194I|IL5RA_ENST00000445864.2_Intron|IL5RA_ENST00000438560.1_Silent_p.I194I|IL5RA_ENST00000430514.2_Silent_p.I194I|IL5RA_ENST00000383846.1_Silent_p.I194I|IL5RA_ENST00000418488.2_Silent_p.I194I	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	194					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		ACCAGCATGCGATATTTCTCC	0.483000													5	74					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93185163	93185163	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr10:93185163G>T	ENST00000446394.1	+	2	364	c.264G>T	c.(262-264)aaG>aaT	p.K88N	HECTD2_ENST00000371681.4_Missense_Mutation_p.K88N|HECTD2_ENST00000298068.5_Missense_Mutation_p.K88N			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	88					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						CTAACATCAAGAATGGtaaat	0.294000													4	16					0.00024832	0.000296074	1	1	0
WISP3	8838	broad.mit.edu	37	6	112390582	112390582	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr6:112390582C>A	ENST00000361714.1	+	5	923	c.878C>A	c.(877-879)tCc>tAc	p.S293Y	WISP3_ENST00000368666.2_Missense_Mutation_p.S275Y|WISP3_ENST00000230529.5_Missense_Mutation_p.S275Y|WISP3_ENST00000368663.3_Missense_Mutation_p.S252Y|WISP3_ENST00000604763.1_Missense_Mutation_p.S275Y|WISP3_ENST00000409166.1_Missense_Mutation_p.S51Y			O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	275	CTCK.				cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	13		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TTCCAACTCTCCAAAGCTGAA	0.328000													3	44					0.115264	0.119106	1	1	0
NMT1	4836	broad.mit.edu	37	17	43182277	43182277	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr17:43182277C>A	ENST00000592782.1	+	12	1514	c.1383C>A	c.(1381-1383)ttC>ttA	p.F461L	NMT1_ENST00000258960.2_Missense_Mutation_p.F461L			P30419	NMT1_HUMAN	N-myristoyltransferase 1	461					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				ACAAAACCTTCCTGGAGAAGC	0.502000													3	38					0.115264	0.119106	1	1	0
ABCB6	10058	broad.mit.edu	37	2	220078333	220078333	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:220078333T>C	ENST00000265316.3	-	10	1950	c.1634A>G	c.(1633-1635)aAt>aGt	p.N545S	ABCB6_ENST00000439002.2_Missense_Mutation_p.N499S	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	545	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCAAACCAATTGAGGGGCAT	0.532000													4	76					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838561	22838563	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:22838561_22838563delAAG	ENST00000404138.1	+	12	2906_2908	c.2395_2397delAAG	c.(2395-2397)del	p.K803del	ZBTB40_ENST00000375647.4_In_Frame_Del_p.K803del|ZBTB40_ENST00000374651.4_In_Frame_Del_p.K691del	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	803					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CGATGCCCCCAAGAAGAAGAAGA	0.517													8	61	---	---	---	---					
CYP4B1	1580	broad.mit.edu	37	1	47283811	47283812	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:47283811_47283812delCT	ENST00000271153.4	+	11	1314_1315	c.1278_1279delCT	c.(1276-1281)gactfs	p.DS426fs	CYP4B1_ENST00000371923.4_Frame_Shift_Del_p.DS427fs|CYP4B1_ENST00000452782.2_Frame_Shift_Del_p.DS264fs|CYP4B1_ENST00000371919.4_Frame_Shift_Del_p.DS412fs			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	426					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					AGGTCTTTGACTCTCTGCGCTT	0.584													8	93	---	---	---	---					
ARL15	54622	broad.mit.edu	37	5	53182535	53182535	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:53182535delT	ENST00000504924.1	-	5	564	c.471delA	c.(469-471)aafs	p.K157fs	ARL15_ENST00000502271.1_5'UTR|ARL15_ENST00000510591.2_5'UTR	NM_019087.2	NP_061960.1	Q9NXU5	ARL15_HUMAN	ADP-ribosylation factor-like 15	157							GTP binding			endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		Lung NSC(810;0.000779)				GTTCAAAATATTTTTTGATCT	0.363													2	4	---	---	---	---					
TMEM38B	55151	broad.mit.edu	37	9	108484899	108484900	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:108484899_108484900insA	ENST00000374688.1	+	4	1087_1088	c.377_378insA	c.(376-378)ttafs	p.L126fs	TMEM38B_ENST00000374692.3_Frame_Shift_Ins_p.L180fs			Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	180						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						CTGAAGATGTCATAGTAAGTTG	0.342													8	69	---	---	---	---					
C11orf48	79081	broad.mit.edu	37	11	62435132	62435134	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:62435132_62435134delTCT	ENST00000431002.2	-	2	2210_2212	c.477_479delAGA	c.(475-480)gat>ga	p.ED159del	C11orf48_ENST00000532208.1_In_Frame_Del_p.ED133del|C11orf48_ENST00000354588.3_In_Frame_Del_p.ED133del|METTL12_ENST00000532971.1_3'UTR			Q9BQE6	CK048_HUMAN	chromosome 11 open reading frame 48	159										endometrium(1)|lung(5)|urinary_tract(1)	7						CCAACAAGCATCTTCTTCATCCT	0.537													15	266	---	---	---	---					
CCNT1	904	broad.mit.edu	37	12	49087434	49087436	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:49087434_49087436delATG	ENST00000261900.3	-	9	1783_1785	c.1561_1563delCAT	c.(1561-1563)del	p.H521del		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	521	His-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGTGGTGATTATGATGATGATGA	0.443													8	406	---	---	---	---