Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WDFY3	23001	broad.mit.edu	37	4	85729569	85729569	+	Splice_Site	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr4:85729569G>A	ENST00000322366.6	-	15	2754	c.2345_splice	c.e15-1	p.R783_splice	WDFY3_ENST00000295888.4_Splice_Site_p.R783_splice|WDFY3-AS1_ENST00000510449.1_RNA			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	783						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGTTCTGCACGACTACAGACA	0.458000													77	136					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169578760	169578760	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:169578760G>C	ENST00000263686.6	-	8	1352	c.1315C>G	c.(1315-1317)Cca>Gca	p.P439A	SELP_ENST00000367788.2_Missense_Mutation_p.P377A|SELP_ENST00000367786.2_Missense_Mutation_p.P377A|SELP_ENST00000367791.2_Intron|SELP_ENST00000367794.2_Missense_Mutation_p.P377A|SELP_ENST00000367792.2_Missense_Mutation_p.P377A|SELP_ENST00000367793.2_Missense_Mutation_p.P377A|SELP_ENST00000458599.2_Missense_Mutation_p.P377A	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	439	Sushi 4.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ACTGGGGCTGGTGCTGTCCAC	0.493000													8	68					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541549	55541549	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr11:55541549C>A	ENST00000361760.1	+	1	636	c.636C>A	c.(634-636)agC>agA	p.S212R		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				AGGTGAGCAGCCTAATTATCA	0.428000													44	77					6.5261e-18	7.3318e-18	1	1	0
LUM	4060	broad.mit.edu	37	12	91502249	91502249	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:91502249G>A	ENST00000266718.4	-	2	962	c.508C>T	c.(508-510)Cgg>Tgg	p.R170W	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	170					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent	p.R170R(1)		central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TCTTTCAGCCGATTGTGCTGG	0.443000													55	60					0	0	1	0	0
SLC39A2	29986	broad.mit.edu	37	14	21469268	21469268	+	Missense_Mutation	SNP	C	C	T	rs2234637	byFrequency	TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr14:21469268C>T	ENST00000298681.4	+	4	617	c.460C>T	c.(460-462)Cat>Tat	p.H154Y	SLC39A2_ENST00000554422.1_3'UTR	NM_014579.3	NP_055394.2	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter), member 2	154			H -> Y (in dbSNP:rs2234637).			cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	14	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		CAGCCATGGACATTTACCCTC	0.582000													7	96					0	0	1	0	0
B3GAT1	27087	broad.mit.edu	37	11	134253908	134253908	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr11:134253908G>A	ENST00000524765.1	-	3	4831	c.287C>T	c.(286-288)cCg>cTg	p.P96L	B3GAT1_ENST00000392580.1_Missense_Mutation_p.P96L|B3GAT1_ENST00000531510.1_5'UTR|B3GAT1_ENST00000312527.4_Missense_Mutation_p.P96L|B3GAT1_ENST00000537389.1_Missense_Mutation_p.P109L			Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	96					carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		CTTCTGCACCGGGCGGCTGTA	0.701000													11	5					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36979565	36979565	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr6:36979565C>G	ENST00000274963.8	+	4	633	c.462C>G	c.(460-462)atC>atG	p.I154M		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	154	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						TCTCCAACATCTCCTCCATCT	0.592000													29	60					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5155093	5155093	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:5155093G>A	ENST00000252321.3	+	1	2009	c.1780G>A	c.(1780-1782)Gtg>Atg	p.V594M		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	594						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						CAAGAGCAACGTGGACTTGCG	0.587000													37	28					0	0	1	0	0
SUZ12P1	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	T	C	rs112064181	by1000genomes	TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr17:29061941T>C	ENST00000582557.1	+	0	861																											TAGATTTCTTTGAACTCGGAA	0.303000													7	105					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366772	248366772	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:248366772C>A	ENST00000456743.1	+	1	441	c.403C>A	c.(403-405)Ctc>Atc	p.L135I		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATACACCAATCTCATGAGCCC	0.433000													132	199					3.87428e-42	4.5787e-42	1	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553474	140553474	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr5:140553474C>T	ENST00000231137.3	+	1	1232	c.1058C>T	c.(1057-1059)aCt>aTt	p.T353I		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		353	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTTCACTTACTAGCCCAATT	0.488000													21	43					0	0	1	0	0
TRMU	55687	broad.mit.edu	37	22	46733801	46733801	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr22:46733801C>T	ENST00000290846.4	+	2	548	c.208C>T	c.(208-210)Caa>Taa	p.Q70*	TRMU_ENST00000424260.2_Nonsense_Mutation_p.Q35*|TRMU_ENST00000381019.3_Nonsense_Mutation_p.Q70*	NM_018006.4	NP_060476.2	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	70						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)	10		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		CCCTTTCCATCAAGTGTCCTA	0.483000													21	113					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54967865	54967865	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr4:54967865C>T	ENST00000326902.2	+	2	1005	c.691C>T	c.(691-693)Cgg>Tgg	p.R231W	FIP1L1_ENST00000507166.1_Intron|GSX2_ENST00000548609.1_3'UTR|GSX2_ENST00000503800.1_3'UTR	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	231						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			GTCTCGACTCCGGAGGATTGA	0.537000													57	111					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119345176	119345176	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr6:119345176T>C	ENST00000338891.7	-	2	1405	c.962A>G	c.(961-963)gAc>gGc	p.D321G	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000522284.1_Missense_Mutation_p.D201G|FAM184A_ENST00000521531.1_Missense_Mutation_p.D321G|FAM184A_ENST00000368475.4_Missense_Mutation_p.D201G|FAM184A_ENST00000352896.5_Missense_Mutation_p.D201G	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	321										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TTGGCATTTGTCAAGAAGACT	0.338000													75	121					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36766264	36766264	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr6:36766264C>A	ENST00000244751.2	-	5	919	c.295G>T	c.(295-297)Gtt>Ttt	p.V99F		NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	99	C2 1.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						TTAGAGTCAACGTCGTATCTG	0.527000													11	27					0.000673444	0.000696402	1	1	0
ZNF724P	440519	broad.mit.edu	37	19	23406747	23406747	+	Silent	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr19:23406747C>T	ENST00000418100.1	-	4	417	c.300G>A	c.(298-300)ctG>ctA	p.L100L																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						CATATTTTCTCAGTATTATTC	0.328000													21	14					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904442	55904442	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr11:55904442G>T	ENST00000301529.1	-	1	752	c.753C>A	c.(751-753)ttC>ttA	p.F251L		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TTGTCCCATAGAAAACCGTGA	0.408000													49	73					2.64894e-19	3.01317e-19	1	1	0
GPR37L1	9283	broad.mit.edu	37	1	202092407	202092407	+	Silent	SNP	C	C	T	rs77385011		TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:202092407C>T	ENST00000367282.4	+	1	422	c.316C>T	c.(316-318)Ctg>Ttg	p.L106L		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1	106						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						GAGGGGCAATCTGACAGGAGC	0.632000													26	30					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55658999	55658999	+	Missense_Mutation	SNP	G	G	T	rs149512476		TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr11:55658999G>T	ENST00000449290.2	+	7	1342	c.1250G>T	c.(1249-1251)gGt>gTt	p.G417V	TRIM51_ENST00000244891.3_Missense_Mutation_p.G274V	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	417	B30.2/SPRY.					intracellular	zinc ion binding										GATTGTGAAGGTAGAACCGTG	0.468000													59	74					1.19403e-26	1.37541e-26	1	1	0
POLR2J4	84820	broad.mit.edu	37	7	44054270	44054270	+	RNA	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr7:44054270C>T	ENST00000427076.1	-	0	291					NR_003655.2																						GTAAAGGCTTCCTGGGGGCTG	0.627000													7	137					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109357023	109357023	+	Silent	SNP	A	A	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr2:109357023A>T	ENST00000283195.6	+	7	987	c.861A>T	c.(859-861)ggA>ggT	p.G287G		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	287					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AAATGAAAGGACATTTCTACA	0.393000													158	228					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104164758	104164758	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr10:104164758T>A	ENST00000020673.5	-	14	2978	c.2452A>T	c.(2452-2454)Agc>Tgc	p.S818C	PSD_ENST00000406432.1_Missense_Mutation_p.S818C	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	818	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TGGTGGATGCTGATGGCATTC	0.612000													19	32					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209353868	209353868	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr2:209353868C>A	ENST00000272847.2	+	11	1421	c.1208C>A	c.(1207-1209)tCc>tAc	p.S403Y	AC019185.4_ENST00000424628.1_RNA|PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	403						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TTCTTCAACTCCTTTCAGGTA	0.473000													36	36					1.60099e-16	1.7553e-16	1	1	0
BFSP1	631	broad.mit.edu	37	20	17475195	17475195	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr20:17475195C>T	ENST00000377873.3	-	8	1561	c.1522G>A	c.(1522-1524)Ggc>Agc	p.G508S	BFSP1_ENST00000544874.1_Missense_Mutation_p.G369S|BFSP1_ENST00000536626.1_Missense_Mutation_p.G369S|BFSP1_ENST00000377868.2_Missense_Mutation_p.G383S	NM_001195.3	NP_001186.1	Q12934	BFSP1_HUMAN	beaded filament structural protein 1, filensin	508	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)|stomach(1)	18						TCCACCTGGCCGTCATAAAGC	0.542000													5	75					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33272139	33272139	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:33272139C>T	ENST00000373477.4	-	4	1362	c.454G>A	c.(454-456)Gtg>Atg	p.V152M		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	152					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TGCTTTACCACCTCAGCTCCA	0.547000													47	136					0	0	1	0	0
TMEM5	10329	broad.mit.edu	37	12	64195968	64195968	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:64195968T>C	ENST00000261234.6	+	4	684	c.526T>C	c.(526-528)Tat>Cat	p.Y176H	TMEM5_ENST00000537373.1_5'UTR|TMEM5_ENST00000537982.1_3'UTR	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	176						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		AAAGATCTTTTATGCCACCCA	0.378000													8	53					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140732056	140732056	+	Silent	SNP	T	T	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr5:140732056T>A	ENST00000523390.1	+	1	2229	c.2229T>A	c.(2227-2229)acT>acA	p.T743T	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGGGGACTTTGCCCTATT	0.552000													18	94					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48677542	48677542	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr3:48677542G>A	ENST00000544264.1	-	35	9771	c.9491C>T	c.(9490-9492)cCc>cTc	p.P3164L	CELSR3_ENST00000164024.4_Missense_Mutation_p.P3159L			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	3159					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGCGGCGGGGCGGAGGCAG	0.706000													19	20					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23524310	23524310	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr14:23524310G>A	ENST00000397359.3	-	3	713	c.454C>T	c.(454-456)Ctt>Ttt	p.L152F	CDH24_ENST00000267383.5_Missense_Mutation_p.L152F|CDH24_ENST00000554034.1_Missense_Mutation_p.L152F|CDH24_ENST00000487137.2_Missense_Mutation_p.L152F	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	152	Cadherin 2.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		TAGGGCCCAAGGGGAAAAATG	0.597000											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	21					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101598236	101598236	+	Silent	SNP	G	G	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr15:101598236G>T	ENST00000284395.5	+	30	4960	c.4560G>T	c.(4558-4560)ccG>ccT	p.P1520P	RP11-505E24.2_ENST00000559857.1_RNA|LRRK1_ENST00000388948.3_Silent_p.P1523P			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1523	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGAAGGACCCGACTTTTGCCA	0.562000													19	34					8.00594e-06	8.37403e-06	1	1	0
KIAA1468	57614	broad.mit.edu	37	18	59919898	59919898	+	Splice_Site	SNP	C	C	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr18:59919898C>A	ENST00000256858.6	+	12	1983	c.1733_splice	c.e12-1	p.Q579_splice	KIAA1468_ENST00000398130.2_Splice_Site_p.Q579_splice			Q9P260	K1468_HUMAN	KIAA1468	579							binding	p.Q579K(3)		autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				ATTTTTCAGGCAAATGATACT	0.383000													6	56					0.0293803	0.0293803	1	1	0
FKTN	2218	broad.mit.edu	37	9	108397458	108397458	+	Silent	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr9:108397458G>A	ENST00000223528.2	+	10	1423	c.1299G>A	c.(1297-1299)acG>acA	p.T433T	FKTN_ENST00000448551.2_Intron|FKTN_ENST00000540160.1_3'UTR|FKTN_ENST00000357998.5_Intron|FKTN_ENST00000602661.1_Silent_p.T433T	NM_006731.2	NP_006722.2	O75072	FKTN_HUMAN	fukutin	433					muscle organ development|negative regulation of cell proliferation|negative regulation of JNK cascade|nervous system development|regulation of protein glycosylation	cis-Golgi network|endoplasmic reticulum|extracellular space|Golgi membrane|integral to membrane|nucleus	transferase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	25						CTGTAAAGACGTGGGACTGGA	0.463000													73	78					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99022765	99022765	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr7:99022765G>A	ENST00000292478.4	-	6	1640	c.1390C>T	c.(1390-1392)Cgg>Tgg	p.R464W	ATP5J2-PTCD1_ENST00000413834.1_Missense_Mutation_p.R513W|PTCD1_ENST00000555673.1_Missense_Mutation_p.R513W	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AAGGCCAGCCGGTCAGCTGGG	0.652000													7	63					0	0	1	0	0
GPRC5D	55507	broad.mit.edu	37	12	13102633	13102633	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:13102633G>A	ENST00000228887.1	-	1	685	c.686C>T	c.(685-687)cCg>cTg	p.P229L	RP11-392P7.6_ENST00000394742.3_RNA|RP11-392P7.6_ENST00000543515.2_RNA|GPRC5D_ENST00000396333.3_Missense_Mutation_p.P229L|RP11-392P7.6_ENST00000540198.1_RNA|RP11-392P7.6_ENST00000536029.1_RNA|RP11-392P7.6_ENST00000545914.1_RNA|RP11-392P7.6_ENST00000542078.1_RNA	NM_018654.1	NP_061124.1	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5, member D	229						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(2)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		CTGGAACTGCGGGTTGCCTCT	0.562000													37	97					0	0	1	0	0
XPO7	23039	broad.mit.edu	37	8	21843168	21843168	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr8:21843168G>T	ENST00000434536.1	+	13	1672	c.1570G>T	c.(1570-1572)Gag>Tag	p.E524*	XPO7_ENST00000252512.9_Nonsense_Mutation_p.E515*|XPO7_ENST00000433566.4_Nonsense_Mutation_p.E516*			Q9UIA9	XPO7_HUMAN	exportin 7	515					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CAGCACTGATGAGCAAGACGC	0.562000													80	107					6.86016e-32	8.00352e-32	1	1	0
C6orf58	352999	broad.mit.edu	37	6	127898604	127898604	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr6:127898604C>G	ENST00000329722.7	+	1	286	c.274C>G	c.(274-276)Ctg>Gtg	p.L92V	C6orf58_ENST00000498112.1_Intron	NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	92						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		GGGGTTGCCTCTGCAGTATGG	0.378000													70	90					0	0	1	0	0
SRP54-AS1	100506157	broad.mit.edu	37	14	35409214	35409214	+	RNA	SNP	T	T	C	rs1967723	by1000genomes	TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr14:35409214T>C	ENST00000556355.1	-	0	257				RP11-85K15.2_ENST00000555015.1_RNA																							CAACTTCTAATTCATCTCGCC	0.448000													4	52					0	0	1	0	0
ILVBL	10994	broad.mit.edu	37	19	15230293	15230293	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr19:15230293T>C	ENST00000263383.3	-	8	989	c.850A>G	c.(850-852)Aag>Gag	p.K284E	ILVBL_ENST00000534378.1_Missense_Mutation_p.K177E|ILVBL_ENST00000531635.1_5'UTR	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	284						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						AGAGGCCTCTTGGCCCGGCTC	0.547000													7	43					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24582098	24582098	+	Missense_Mutation	SNP	C	C	T	rs116820424	by1000genomes	TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr22:24582098C>T	ENST00000358321.3	+	9	1715	c.1454C>T	c.(1453-1455)gCg>gTg	p.A485V		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	485	VWFD.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						AGGGTGCAGGCGCGGGCCCAG	0.647000													3	27					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22141024	22141024	+	Silent	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:22141024C>T	ENST00000344642.2	+	2	406	c.219C>T	c.(217-219)ccC>ccT	p.P73P	LDLRAD2_ENST00000543870.1_Silent_p.P73P	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	73						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		CGGCAGCCCCCGGCGACCGGA	0.731000													19	26					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49569031	49569031	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr3:49569031C>G	ENST00000545947.1	+	6	1809	c.1087C>G	c.(1087-1089)Cct>Gct	p.P363A	DAG1_ENST00000541308.1_Missense_Mutation_p.P363A|DAG1_ENST00000539901.1_Missense_Mutation_p.P363A|DAG1_ENST00000538711.1_Missense_Mutation_p.P363A|DAG1_ENST00000515359.2_Missense_Mutation_p.P363A|DAG1_ENST00000308775.2_Missense_Mutation_p.P363A	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	363	Mucin-like domain.|Required for laminin recognition.|Thr-rich.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGATCCTGTTCCTGGGAAACC	0.607000													42	112					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081316	152081316	+	Silent	SNP	A	A	G	rs143332338	by1000genomes	TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:152081316A>G	ENST00000368804.1	-	2	4376	c.4377T>C	c.(4375-4377)cgT>cgC	p.R1459R		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1459	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTTTCTGTGACGCTCCTGGC	0.547000													10	189					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69736466	69736466	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr2:69736466T>C	ENST00000409085.4	-	14	2279	c.1903A>G	c.(1903-1905)Att>Gtt	p.I635V	AAK1_ENST00000409068.1_Missense_Mutation_p.I635V|AAK1_ENST00000406297.3_Missense_Mutation_p.I635V	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	635						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						TCACTGAGAATACGCCTGTGC	0.572000													46	54					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642321	57642321	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr19:57642321G>T	ENST00000254181.4	+	4	2732	c.2278G>T	c.(2278-2280)Gcc>Tcc	p.A760S	USP29_ENST00000598197.1_Missense_Mutation_p.A760S	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	760					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAGCTGGATGCCCAGGAACA	0.488000													21	35					3.51602e-12	3.80902e-12	1	1	0
SMC2	10592	broad.mit.edu	37	9	106888954	106888954	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr9:106888954G>T	ENST00000286398.7	+	19	2772	c.2484G>T	c.(2482-2484)gaG>gaT	p.E828D	SMC2_ENST00000303219.8_Missense_Mutation_p.E828D|SMC2_ENST00000374787.3_Missense_Mutation_p.E828D|SMC2_ENST00000374793.3_Missense_Mutation_p.E828D	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	828					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						AACTGGAAGAGCTCAAGAGAG	0.353000													33	38					7.16026e-08	7.57655e-08	1	1	0
FAM129C	199786	broad.mit.edu	37	19	17651299	17651299	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr19:17651299C>T	ENST00000335393.4	+	10	1309	c.1171C>T	c.(1171-1173)Ctc>Ttc	p.L391F	FAM129C_ENST00000600871.1_Missense_Mutation_p.L337F|FAM129C_ENST00000599124.1_Missense_Mutation_p.L360F|FAM129C_ENST00000449408.2_Missense_Mutation_p.L117F|FAM129C_ENST00000599164.1_Missense_Mutation_p.L360F|FAM129C_ENST00000352727.3_Missense_Mutation_p.L391F|FAM129C_ENST00000332386.5_Missense_Mutation_p.L391F|FAM129C_ENST00000300971.2_Missense_Mutation_p.L391F|FAM129C_ENST00000595684.1_Missense_Mutation_p.L391F|FAM129C_ENST00000601861.1_Missense_Mutation_p.L360F	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	391										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						GGAAGCCTCGCTCGAGGCGGT	0.721000													18	3					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14766109	14766109	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:14766109T>A	ENST00000261170.3	-	27	3300	c.3164A>T	c.(3163-3165)aAa>aTa	p.K1055I	RP11-695J4.2_ENST00000542401.1_RNA|RP11-695J4.2_ENST00000545424.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1055					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CAGAGTGCCTTTTTTATAGCT	0.408000													21	334					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C|FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				12	13					0	0	1	0	0
MYO1D	4642	broad.mit.edu	37	17	31082577	31082577	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr17:31082577G>C	ENST00000318217.5	-	11	1704	c.1400C>G	c.(1399-1401)aCc>aGc	p.T467S	MYO1D_ENST00000394649.4_Missense_Mutation_p.T379S|MYO1D_ENST00000579584.1_Missense_Mutation_p.T467S|MYO1D_ENST00000584232.1_5'UTR	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	467	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CATTTCATCGGTGACTTTGCC	0.413000													37	40					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36702000	36702000	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr22:36702000A>T	ENST00000216181.5	-	17	2365	c.2135T>A	c.(2134-2136)gTg>gAg	p.V712E		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	712	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CTGGAAGACCACCCTGTTGGG	0.672000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				36	64					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123435004	123435004	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:123435004A>T	ENST00000542678.1	-	3	3548	c.710T>A	c.(709-711)aTt>aAt	p.I237N	ABCB9_ENST00000442028.2_Missense_Mutation_p.I237N|ABCB9_ENST00000280560.8_Missense_Mutation_p.I237N|ABCB9_ENST00000346530.5_Missense_Mutation_p.I237N|ABCB9_ENST00000540285.1_Missense_Mutation_p.I237N|ABCB9_ENST00000344275.7_Missense_Mutation_p.I237N|ABCB9_ENST00000392439.3_Missense_Mutation_p.I237N|ABCB9_ENST00000442833.2_Missense_Mutation_p.I237N			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	237	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CTACCTGCCAATGGCCAGCAG	0.632000													12	5					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94008911	94008911	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr14:94008911G>A	ENST00000553484.1	+	14	1778	c.1624G>A	c.(1624-1626)Gat>Aat	p.D542N	UNC79_ENST00000393151.2_Missense_Mutation_p.D542N|UNC79_ENST00000256339.4_Missense_Mutation_p.D365N|UNC79_ENST00000555664.1_Missense_Mutation_p.D542N			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	542						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GTATATGATGGATGATGAAGT	0.517000													44	28					0	0	1	0	0
C19orf57	79173	broad.mit.edu	37	19	14000402	14000402	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr19:14000402G>A	ENST00000454313.1	-	6	1325	c.1267C>T	c.(1267-1269)Cct>Tct	p.P423S	C19orf57_ENST00000586783.1_Missense_Mutation_p.P423S|C19orf57_ENST00000346736.2_Missense_Mutation_p.P423S|C19orf57_ENST00000591586.1_Intron			Q0VDD7	CS057_HUMAN	chromosome 19 open reading frame 57	423					multicellular organismal development		protein binding			breast(2)|kidney(1)|lung(3)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CCGCTCCCAGGTGCCAGAGCC	0.627000													27	92					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21236404	21236404	+	Splice_Site	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr2:21236404C>T	ENST00000233242.1	-	25	3971	c.3842_splice	c.e25-1	p.D1282_splice		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1282					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACCCGGCCATCGCTGAAATGA	0.413000													38	61					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35453087	35453087	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr1:35453087C>T	ENST00000357182.4	-	16	3823	c.3596G>A	c.(3595-3597)aGt>aAt	p.S1199N	ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000487874.1_Intron	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1199					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AAAACAGTCACTGAACACTTG	0.368000													59	77					0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117780594	117780594	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr11:117780594C>T	ENST00000528626.1	-	7	1004	c.931G>A	c.(931-933)Ggc>Agc	p.G311S	TMPRSS13_ENST00000524993.1_Missense_Mutation_p.G346S|TMPRSS13_ENST00000526090.1_Missense_Mutation_p.G346S|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.G346S|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.G346S	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	341	SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		TGGGTGGTGCCGAAGTGCAGA	0.627000													3	35					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119947910	119947910	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr4:119947910C>T	ENST00000307142.4	+	3	582	c.386C>T	c.(385-387)aCa>aTa	p.T129I	SYNPO2_ENST00000434046.2_Missense_Mutation_p.T129I|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.T129I	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	129						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ACCCAGTGCACAGAATTCTTC	0.502000													25	49					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149212836	149212836	+	Silent	SNP	C	C	G			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr5:149212836C>G	ENST00000309241.5	+	5	1232	c.1200C>G	c.(1198-1200)ccC>ccG	p.P400P	PPARGC1B_ENST00000360453.4_Silent_p.P361P|PPARGC1B_ENST00000403750.1_Silent_p.P336P|PPARGC1B_ENST00000394320.3_Silent_p.P400P	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	400					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CAGCTTCACCCAAGAGCACCG	0.677000													4	70					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25011639	25011639	+	Silent	SNP	A	A	G	rs60849220	by1000genomes	TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr20:25011639A>G	ENST00000537502.1	-	1	1669	c.138T>C	c.(136-138)ttT>ttC	p.F46F	ACSS1_ENST00000432802.2_Intron|ACSS1_ENST00000323482.4_Intron|ACSS1_ENST00000542618.1_Intron			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	0	Poly-Ala.				acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GAGGAGGGCCAAAATGCAGAG	0.517000													3	18					0	0	1	0	0
SRP14	6727	broad.mit.edu	37	15	40330522	40330522	+	Silent	SNP	C	C	A			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr15:40330522C>A	ENST00000267884.6	-	3	242	c.171G>T	c.(169-171)ctG>ctT	p.L57L	SRP14_ENST00000558527.1_5'UTR|SRP14_ENST00000558720.1_5'UTR|SRP14_ENST00000560773.1_5'UTR|SRP14_ENST00000559081.1_Silent_p.L57L	NM_003134.4	NP_003125.3	P37108	SRP14_HUMAN	signal recognition particle 14kDa (homologous Alu RNA binding protein)	57					negative regulation of translational elongation|response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		TAGCTCTTAACAGACACTTGT	0.448000													40	62					4.32679e-17	4.80168e-17	1	1	0
AFTPH	54812	broad.mit.edu	37	2	64778672	64778674	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr2:64778672_64778674delGAT	ENST00000422803.1	+	2	378_380	c.64_66delGAT	c.(64-66)del	p.D26del	AFTPH_ENST00000238856.4_In_Frame_Del_p.D26del|AFTPH_ENST00000238855.7_In_Frame_Del_p.D26del|AFTPH_ENST00000409933.1_In_Frame_Del_p.D26del			Q6ULP2	AFTIN_HUMAN	aftiphilin	26					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						TGGAGCAGAGGATGATGATGATG	0.409													7	252	---	---	---	---					
ZXDC	79364	broad.mit.edu	37	3	126178522	126178522	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr3:126178522delT	ENST00000389709.3	-	7	2239	c.2186delA	c.(2185-2187)agfs	p.K729fs		NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	729					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		TCCTCTCTGCTTTTTTTCCTT	0.522													7	944	---	---	---	---					
CRB2	286204	broad.mit.edu	37	9	126136215	126136216	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr9:126136215_126136216insG	ENST00000359999.3	+	10	3496_3497	c.3405_3406insG	c.(3403-3408)gcggggfs	p.AG1135fs	CRB2_ENST00000373631.3_Intron|CRB2_ENST00000373629.2_Intron			Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	909	EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						ATGGCTGGGCAGGGGGGTGGGC	0.698													3	3	---	---	---	---					
GOLGA2P5	55592	broad.mit.edu	37	12	100562920	100562921	+	RNA	INS	-	-	T	rs58822438		TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr12:100562920_100562921insT	ENST00000397112.4	-	0	599					NR_036632.1															large_intestine(1)|lung(3)	4						GGTCTCATTTGTTTTttttttt	0.406													3	3	---	---	---	---					
RP11-697E22.2	0	broad.mit.edu	37	17	36003614	36003614	+	RNA	DEL	T	T	-	rs10543338		TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr17:36003614delT	ENST00000586163.1	+	0	590				RP11-697E22.2_ENST00000586950.1_RNA																							ATTAtttatcttttttttttt	0.507													2	4	---	---	---	---					
EPS15L1	58513	broad.mit.edu	37	19	16528778	16528785	+	Frame_Shift_Del	DEL	TCCGAAGG	TCCGAAGG	-			TCGA-BA-A4IH-01A-11D-A25Y-08	TCGA-BA-A4IH-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cde5f95c-db1d-420f-bc33-d32aa1b8d814	d61cf248-b477-4677-81b8-43448f607e3d	g.chr19:16528778_16528785delTCCGAAGG	ENST00000602009.1	-	5	1514_1521	c.619_626delCCTTCGGA	c.(619-627)gfs	p.PSE207fs	EPS15L1_ENST00000594975.1_Frame_Shift_Del_p.PSE361fs|EPS15L1_ENST00000455140.2_Frame_Shift_Del_p.PSE361fs|EPS15L1_ENST00000597937.1_Frame_Shift_Del_p.PSE361fs|EPS15L1_ENST00000535753.2_Frame_Shift_Del_p.PSE361fs|EPS15L1_ENST00000248070.6_Frame_Shift_Del_p.PSE361fs			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	361	EH 2.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						CGTGCCTCTCTCCGAAGGCGGGACCATG	0.587											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	14	---	---	---	---