Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NFATC2	4773	broad.mit.edu	37	20	50090571	50090571	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr20:50090571C>G	ENST00000371564.3	-	5	1873	c.1654G>C	c.(1654-1656)Gag>Cag	p.E552Q	NFATC2_ENST00000414705.1_Missense_Mutation_p.E532Q|NFATC2_ENST00000396009.3_Missense_Mutation_p.E552Q	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	552	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CCACTGGACTCTGGGATGTGA	0.537000													21	83					0	0	1	0	0
ST3GAL6	10402	broad.mit.edu	37	3	98510706	98510706	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:98510706G>A	ENST00000265261.6	+	9	846	c.424G>A	c.(424-426)Gga>Aga	p.G142R	ST3GAL6_ENST00000462152.1_3'UTR|ST3GAL6_ENST00000394162.1_Missense_Mutation_p.G260R|ST3GAL6_ENST00000483910.1_Missense_Mutation_p.G260R	NM_001271147.1	NP_001258076.1	Q9Y274	SIA10_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	260					amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(1)	19						CCCAACAACAGGAATTATTGC	0.388000													4	207					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226273793	226273793	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:226273793G>A	ENST00000272907.6	+	2	610	c.197G>A	c.(196-198)cGa>cAa	p.R66Q	NYAP2_ENST00000409269.2_Missense_Mutation_p.R66Q	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	66																	GAAAAACGCCGAAGACAAGAA	0.368000													11	17					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16890496	16890496	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:16890496G>C	ENST00000430580.2	-	29	4249	c.3362C>G	c.(3361-3363)aCt>aGt	p.T1121S		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	0	NBPF 8.|Poly-Arg.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCCCATCAAAGTAAGAAACCT	0.473000													47	895					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330260	125330260	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:125330260C>A	ENST00000304865.2	-	1	578	c.497G>T	c.(496-498)cGt>cTt	p.R166L		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						GAAGGTGAGACGATTCAGCAG	0.498000													21	73					0.000175454	0.000179296	1	1	0
KIAA0513	9764	broad.mit.edu	37	16	85121917	85121917	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:85121917A>G	ENST00000566428.1	+	13	1853	c.1222A>G	c.(1222-1224)Atg>Gtg	p.M408V	KIAA0513_ENST00000258180.3_Missense_Mutation_p.M408V|KIAA0513_ENST00000538274.1_Missense_Mutation_p.M398V			O60268	K0513_HUMAN	KIAA0513	408						cytoplasm				breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(9)|pancreas(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.234)		CATTGAGCAAATGGCCACTGA	0.562000													16	73					0	0	1	0	0
LDLRAP1	26119	broad.mit.edu	37	1	25883713	25883713	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:25883713C>A	ENST00000374338.4	+	4	533	c.414C>A	c.(412-414)aaC>aaA	p.N138K	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	138	PID.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		GCCAGCACAACCAGAGCCTCG	0.602000													30	82					1.61788e-16	1.78349e-16	1	1	0
GPT2	84706	broad.mit.edu	37	16	46952615	46952615	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:46952615C>A	ENST00000440783.2	+	8	1348	c.683C>A	c.(682-684)tCc>tAc	p.S228Y	GPT2_ENST00000340124.4_Missense_Mutation_p.S328Y	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	328					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCCGAGTACTCCAGCAACGTG	0.617000													41	157					1.96642e-18	2.22015e-18	1	1	0
RWDD3	25950	broad.mit.edu	37	1	95709957	95709957	+	Silent	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:95709957G>A	ENST00000429514.2	+	3	437	c.231G>A	c.(229-231)gaG>gaA	p.E77E	RWDD3_ENST00000495272.1_3'UTR|RWDD3_ENST00000370202.4_Silent_p.E92E|RP11-57H12.6_ENST00000604534.1_3'UTR|RP11-57H12.5_ENST00000444665.1_RNA|RWDD3_ENST00000263893.6_Silent_p.E92E			Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3	92	RWD.					cytoplasm|nucleus	protein binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)	10		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)		AGCAAGCAGAGAGCCTTTTGT	0.468000													23	67					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125618102	125618102	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:125618102G>A	ENST00000373670.1	-	13	3110	c.2510C>T	c.(2509-2511)tCt>tTt	p.S837F	RC3H2_ENST00000357244.2_Missense_Mutation_p.S837F|RC3H2_ENST00000423239.2_Missense_Mutation_p.S837F			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	837						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						AGACCAGGGAGAATAATGGGA	0.353000													22	56					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53472914	53472914	+	RNA	SNP	A	A	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:53472914A>G	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							TTTGATTTTCAATTAAAAACC	0.338000													3	20					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578530	7578530	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:7578530A>C	ENST00000420246.2	-	5	532	c.400T>G	c.(400-402)Ttt>Gtt	p.F134V	TP53_ENST00000413465.2_Missense_Mutation_p.F134V|TP53_ENST00000269305.4_Missense_Mutation_p.F134V|TP53_ENST00000455263.2_Missense_Mutation_p.F134V|TP53_ENST00000445888.2_Missense_Mutation_p.F134V|TP53_ENST00000359597.4_Missense_Mutation_p.F134V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	134	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		F -> C (in sporadic cancers; somatic mutation).|F -> I (in sporadic cancers; somatic mutation).|F -> L (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.F134L(16)|p.F134V(12)|p.0?(8)|p.C135fs*35(5)|p.M133fs*36(3)|p.N131fs*27(2)|p.V73fs*9(1)|p.F2V(1)|p.F41V(1)|p.S127fs*36(1)|p.?(1)|p.Y126fs*11(1)|p.F134fs*39(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.F41L(1)|p.F2L(1)|p.M133fs*13(1)|p.M40fs*36(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGTTGGCAAAACATCTTGTTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	32					0	0	1	0	0
MSC	9242	broad.mit.edu	37	8	72756257	72756257	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr8:72756257C>T	ENST00000325509.4	-	1	446	c.157G>A	c.(157-159)Gac>Aac	p.D53N	RP11-383H13.1_ENST00000521467.1_Intron|RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron	NM_005098.3	NP_005089.2	O60682	MUSC_HUMAN	musculin	53	Glu-rich (acidic).				transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(4)|skin(2)	26	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			TCCTCGCCGTCGGGGTCCTCC	0.736000											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	1	0	0
CMIP	80790	broad.mit.edu	37	16	81733384	81733384	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:81733384G>C	ENST00000537098.3	+	15	1805	c.1733G>C	c.(1732-1734)aGg>aCg	p.R578T	CMIP_ENST00000398040.4_Missense_Mutation_p.R425T|CMIP_ENST00000566513.1_3'UTR|CMIP_ENST00000539778.2_Missense_Mutation_p.R484T	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	544						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						CTGGCACTGAGGGGGAACCAG	0.597000													8	39					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			28	25					0	0	1	0	0
MDH2	4191	broad.mit.edu	37	7	75695628	75695628	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:75695628G>A	ENST00000315758.5	+	9	1011	c.917G>A	c.(916-918)gGc>gAc	p.G306D	MDH2_ENST00000432020.2_Missense_Mutation_p.G264D|MDH2_ENST00000443006.1_Missense_Mutation_p.G199D	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	306					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	CTGGGCATCGGCAAAGTCTCC	0.493000													4	84					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437244	120437244	+	Silent	SNP	C	C	A	rs145951922	byFrequency	TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:120437244C>A	ENST00000369400.1	-	1	1874	c.1716G>T	c.(1714-1716)acG>acT	p.T572T		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	572	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AAATTATAGTCGTATGCTCTG	0.398000													4	187					1	1	1	1	0
DDR1	780	broad.mit.edu	37	6	30866962	30866962	+	Silent	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:30866962G>A	ENST00000324771.8	+	20	3179	c.2631G>A	c.(2629-2631)ccG>ccA	p.P877P	DDR1_ENST00000454612.2_Silent_p.P840P|DDR1_ENST00000418800.2_Silent_p.P840P|DDR1_ENST00000513240.1_Silent_p.P883P|DDR1_ENST00000376570.4_Silent_p.P840P|DDR1_ENST00000376569.3_Silent_p.P840P|DDR1_ENST00000376575.3_Silent_p.P883P|DDR1_ENST00000361741.4_Intron|DDR1_ENST00000508312.1_Silent_p.P858P|DDR1_ENST00000376568.3_Silent_p.P877P|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000452441.1_Silent_p.P877P|DDR1_ENST00000376567.2_Silent_p.P840P			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	877	Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CTGCCTGCCCGCAGGGCCTAT	0.577000													32	153					0	0	1	0	0
CLDN22	53842	broad.mit.edu	37	4	184241063	184241063	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr4:184241063G>C	ENST00000323319.5	-	1	864	c.309C>G	c.(307-309)gaC>gaG	p.D103E	WWC2_ENST00000403733.3_3'UTR	NM_001111319.1	NP_001104789.1	Q8N7P3	CLD22_HUMAN	claudin 22	103					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			cervix(1)|kidney(1)|lung(3)|prostate(1)|skin(1)	7		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.0172)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|Esophageal squamous(56;0.176)		all cancers(43;4.1e-26)|Epithelial(43;6.45e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|Colorectal(24;5.87e-06)|GBM - Glioblastoma multiforme(59;6.5e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TTCTCAAACAGTCCAGGCCAA	0.552000													9	31					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5085765	5085765	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:5085765T>C	ENST00000399604.4	-	1	1927	c.1787A>G	c.(1786-1788)tAt>tGt	p.Y596C	ZNF594_ENST00000575779.1_Missense_Mutation_p.Y596C			Q96JF6	ZN594_HUMAN	zinc finger protein 594	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTTGCATTCATATGGTTTCTC	0.418000													20	206					0	0	1	0	0
CHST5	23563	broad.mit.edu	37	16	75563775	75563775	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:75563775C>T	ENST00000336257.3	-	3	1902	c.508G>A	c.(508-510)Gta>Ata	p.V170I	RP11-77K12.7_ENST00000460606.1_3'UTR|CHST5_ENST00000541075.1_Missense_Mutation_p.V176I	NM_024533.4	NP_078809.2	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	170					N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)	24						GTCTTGCATACGTCCTGCTTG	0.652000													83	295					0	0	1	0	0
DNAJC25	548645	broad.mit.edu	37	9	114411821	114411821	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:114411821A>T	ENST00000313525.3	+	3	634	c.578A>T	c.(577-579)aAg>aTg	p.K193M	DNAJC25-GNG10_ENST00000374294.3_Intron|DNAJC25_ENST00000556107.1_Intron	NM_001015882.2	NP_001015882.2	Q9H1X3	DJC25_HUMAN	DnaJ (Hsp40) homolog, subfamily C , member 25	193					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|skin(4)	8						GAGATTGCCAAGCAGCAGGGA	0.403000													8	30					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187628173	187628173	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr4:187628173G>A	ENST00000441802.2	-	2	3018	c.2809C>T	c.(2809-2811)Cga>Tga	p.R937*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	937	Cadherin 8.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGATCCTCTCGGACTTTCACA	0.468000										HNSCC(5;0.00058)			113	170					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70045128	70045128	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:70045128T>A	ENST00000358769.2	-	9	933	c.731A>T	c.(730-732)cAt>cTt	p.H244L	PBLD_ENST00000495025.1_5'UTR|PBLD_ENST00000309049.4_Missense_Mutation_p.H244L|PBLD_ENST00000336578.1_Missense_Mutation_p.H211L|PBLD_ENST00000432941.1_Missense_Mutation_p.H244L	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	244					biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						CTTCCCCAGATGCTGGGACCA	0.433000													30	125					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119204767	119204767	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:119204767G>A	ENST00000313400.4	-	21	3663	c.3563C>T	c.(3562-3564)aCg>aTg	p.T1188M	ASTN2_ENST00000361477.3_Missense_Mutation_p.T240M|ASTN2_ENST00000361209.2_Missense_Mutation_p.T1137M|ASTN2_ENST00000373996.3_Missense_Mutation_p.T1184M|ASTN2_ENST00000288520.5_Missense_Mutation_p.T289M|ASTN2_ENST00000341734.4_Missense_Mutation_p.T240M			O75129	ASTN2_HUMAN	astrotactin 2	1188	Fibronectin type-III.					integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TGGACAGGCCGTCCTCAGGGT	0.512000													16	109					0	0	1	0	0
EML2	24139	broad.mit.edu	37	19	46117912	46117912	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:46117912C>T	ENST00000536630.1	-	20	2223	c.2085G>A	c.(2083-2085)agG>agA	p.R695R	EML2_ENST00000587152.1_Silent_p.R749R|EML2_ENST00000245925.3_Silent_p.R548R|EML2_ENST00000589876.1_Silent_p.R548R	NM_001193269.1	NP_001180198.1	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like 2	548					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|urinary_tract(1)	31		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		ATTCCATGTTCCTCACAGCAT	0.522000													32	167					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059462	9059462	+	Silent	SNP	A	A	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:9059462A>T	ENST00000397910.4	-	3	28187	c.27984T>A	c.(27982-27984)tcT>tcA	p.S9328S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9330	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGTTCTGCTAGAAGAGATGG	0.493000													70	128					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350033	100350033	+	RNA	SNP	T	T	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:100350033T>C	ENST00000542585.1	+	0	2453				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCACCATCTCCCCAGAAAA	0.522000													8	150					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37365649	37365649	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:37365649A>G	ENST00000361924.2	+	14	2646	c.2272A>G	c.(2272-2274)Att>Gtt	p.I758V	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.I780V	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	758	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AAAAGATCAAATTAATCAACT	0.383000													13	64					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147183111	147183111	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:147183111C>G	ENST00000361727.3	+	11	2271	c.1755C>G	c.(1753-1755)taC>taG	p.Y585*		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	585	EGF-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGACAGGATACAGTGGGGCCA	0.468000										HNSCC(39;0.1)			7	78					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38424508	38424508	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:38424508C>T	ENST00000356264.2	-	21	2214	c.1999G>A	c.(1999-2001)Gga>Aga	p.G667R	AMPH_ENST00000428293.2_Missense_Mutation_p.G625R|AMPH_ENST00000325590.5_Missense_Mutation_p.G625R	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	667	SH3.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TCCTTCACTCCCACCAGCCAG	0.458000													17	76					0	0	1	0	0
HSPB3	8988	broad.mit.edu	37	5	53751746	53751746	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:53751746G>T	ENST00000302005.1	+	1	302	c.127G>T	c.(127-129)Gtg>Ttg	p.V43L		NM_006308.2	NP_006299.1	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	43					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus				breast(1)|large_intestine(4)|prostate(3)	8		Lung NSC(810;0.00104)				GCCAACCATCGTGGACCTGAG	0.552000													8	82					5.18039e-06	5.37226e-06	1	1	0
FRMPD2	143162	broad.mit.edu	37	10	49393657	49393657	+	Silent	SNP	T	T	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:49393657T>A	ENST00000374201.3	-	18	2600	c.2298A>T	c.(2296-2298)atA>atT	p.I766I	FRMPD2_ENST00000305531.3_Silent_p.I741I|FRMPD2_ENST00000407470.4_Silent_p.I734I	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	766					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CCGGTTCAGCTATAAAGCTCT	0.473000													22	67					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98762697	98762697	+	Silent	SNP	G	G	A	rs148583876		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:98762697G>A	ENST00000266058.4	-	35	4163	c.3918C>T	c.(3916-3918)aaC>aaT	p.N1306N	SLIT1_ENST00000371070.4_Silent_p.N1306N|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1306	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGCCGGTGCCGTTGAGGATCT	0.607000													69	232					0	0	1	0	0
TRIM7	81786	broad.mit.edu	37	5	180627055	180627055	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:180627055C>T	ENST00000393315.1	-	3	718	c.21G>A	c.(19-21)aaG>aaA	p.K7K	TRIM7_ENST00000393319.3_Silent_p.K33K|TRIM7_ENST00000274773.7_Silent_p.K215K|CTC-338M12.6_ENST00000511517.1_RNA|TRIM7_ENST00000422067.2_Silent_p.K7K|CTC-338M12.6_ENST00000509080.1_RNA|CTC-338M12.6_ENST00000502812.2_RNA|TRIM7_ENST00000361809.3_Silent_p.K7K|CTC-338M12.6_ENST00000419707.2_RNA	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	215						cytoplasm|nucleus	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		CTGCCCCCACCTTCTCCTGCT	0.602000													51	57					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108608643	108608643	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:108608643C>T	ENST00000264047.2	+	3	536	c.260C>T	c.(259-261)gCa>gTa	p.A87V	SLC5A7_ENST00000409059.1_Missense_Mutation_p.A87V|SLC5A7_ENST00000540517.1_5'UTR	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	87					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	TGGGCTCAGGCACCAATTGGA	0.413000													13	53					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1985046	1985046	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr4:1985046C>T	ENST00000382882.3	-	11	2737	c.1620G>A	c.(1618-1620)taG>taA	p.*540*	NELFA_ENST00000411638.1_Silent_p.*529*|NELFA_ENST00000542778.1_Silent_p.*394*	NM_005663.4	NP_005654.3			negative elongation factor complex member A																		GCAGGTGGTTCTAGGACACAT	0.577000													9	97					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100387174	100387174	+	Silent	SNP	A	A	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr14:100387174A>T	ENST00000262233.6	+	17	2008	c.1869A>T	c.(1867-1869)acA>acT	p.T623T	EML1_ENST00000327921.9_Silent_p.T611T|EML1_ENST00000334192.4_Silent_p.T642T	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	623						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CCGTTCACACAGATGGAAACG	0.353000													13	80					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12321202	12321202	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:12321202C>G	ENST00000358136.3	+	12	1540	c.1410C>G	c.(1408-1410)atC>atG	p.I470M	VPS13D_ENST00000356315.4_Missense_Mutation_p.I470M	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	470					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CTGAAGAGATCCTGGGTACGG	0.478000													31	169					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52138596	52138596	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:52138596G>C	ENST00000596288.1	-	10	1655	c.1628C>G	c.(1627-1629)tCa>tGa	p.S543*	MCM3_ENST00000419835.2_Nonsense_Mutation_p.S452*|MCM3_ENST00000229854.7_Nonsense_Mutation_p.S498*	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	498					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GACATGGTCTGAGATCTCCCG	0.507000													33	96					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51255135	51255135	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:51255135A>T	ENST00000404971.1	-	2	1616	c.277T>A	c.(277-279)Ttc>Atc	p.F93I	NRXN1_ENST00000405581.1_Missense_Mutation_p.F93I|NRXN1_ENST00000406316.2_Missense_Mutation_p.F93I|NRXN1_ENST00000405472.3_Missense_Mutation_p.F93I|NRXN1_ENST00000402717.3_Missense_Mutation_p.F93I|NRXN1_ENST00000401669.2_Missense_Mutation_p.F93I|NRXN1_ENST00000406859.3_Missense_Mutation_p.F93I	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	93	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAGATGGAGAAGCTGAGCTGC	0.682000													5	35					0	0	1	0	0
SSX2IP	117178	broad.mit.edu	37	1	85116066	85116066	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:85116066C>A	ENST00000437941.2	-	12	1920	c.1568G>T	c.(1567-1569)cGt>cTt	p.R523L	SSX2IP_ENST00000603677.1_Missense_Mutation_p.R69L|SSX2IP_ENST00000605755.1_Missense_Mutation_p.R523L|SSX2IP_ENST00000342203.3_Missense_Mutation_p.R550L|SSX2IP_ENST00000370612.4_Missense_Mutation_p.R550L	NM_001166295.1|NM_001166417.1	NP_001159767.1|NP_001159889.1	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting protein	550					cell adhesion	nucleus|protein complex				endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|urinary_tract(1)	19				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TATGCAGGAACGTGTCTGGCA	0.413000													32	154					2.61193e-14	2.8568e-14	1	1	0
TMEM72	643236	broad.mit.edu	37	10	45430235	45430235	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:45430235G>A	ENST00000544540.1	+	4	611	c.127G>A	c.(127-129)Ggc>Agc	p.G43S	TMEM72-AS1_ENST00000450287.2_RNA			A0PK05	TMM72_HUMAN	transmembrane protein 72	161						integral to membrane				breast(2)|kidney(1)|large_intestine(2)|lung(10)	15						GAGCACCACCGGCTCTGGGGA	0.587000													67	213					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13764681	13764681	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr12:13764681G>T	ENST00000279593.3	-	8	1967	c.1758C>A	c.(1756-1758)aaC>aaA	p.N586K		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	586					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGAGGCACCTGTTATAACCCA	0.493000													42	134					9.39024e-22	1.07757e-21	1	1	0
ALDH1B1	219	broad.mit.edu	37	9	38396287	38396287	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:38396287A>G	ENST00000377698.3	+	2	695	c.542A>G	c.(541-543)cAg>cGg	p.Q181R		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	181					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GTCTGTGGCCAGATCATCCCG	0.582000													39	75					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33772191	33772191	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:33772191G>A	ENST00000285013.6	-	3	784	c.509C>T	c.(508-510)tCt>tTt	p.S170F	SLFN13_ENST00000360502.2_Intron|SLFN13_ENST00000542635.1_Missense_Mutation_p.S170F|SLFN13_ENST00000534689.1_Intron|SLFN13_ENST00000533791.1_Missense_Mutation_p.S170F|SLFN13_ENST00000526861.1_Missense_Mutation_p.S170F	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	170						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACTAGGTGGAGACCCTTCATT	0.378000													5	163					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58153055	58153055	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:58153055G>A	ENST00000544273.1	+	5	1564	c.1237G>A	c.(1237-1239)Gaa>Aaa	p.E413K	ZNF211_ENST00000541801.1_Missense_Mutation_p.E392K|ZNF211_ENST00000240731.4_Missense_Mutation_p.E414K|ZNF211_ENST00000391703.3_Missense_Mutation_p.E340K|ZNF211_ENST00000347302.3_Missense_Mutation_p.E401K|ZNF211_ENST00000420680.1_Missense_Mutation_p.E405K|ZNF211_ENST00000299871.5_Missense_Mutation_p.E466K|ZNF211_ENST00000254182.7_Missense_Mutation_p.E392K			Q13398	ZN211_HUMAN	zinc finger protein 211	401						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAGTGCAATGAATGTGGAAA	0.458000													11	70					0	0	1	0	0
NR4A2	4929	broad.mit.edu	37	2	157186571	157186571	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:157186571C>T	ENST00000339562.4	-	3	490	c.128G>A	c.(127-129)aGc>aAc	p.S43N	NR4A2_ENST00000539077.1_Missense_Mutation_p.S54N|NR4A2_ENST00000409572.1_Missense_Mutation_p.S43N|NR4A2_ENST00000429376.1_Intron|NR4A2_ENST00000409108.2_Missense_Mutation_p.S43N|NR4A2_ENST00000426264.1_Intron	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	43					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						GAGGTCCATGCTAAACTTGAC	0.512000													33	58					0	0	1	0	0
RWDD2A	112611	broad.mit.edu	37	6	83905854	83905854	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:83905854G>C	ENST00000369724.4	+	3	947	c.742G>C	c.(742-744)Gag>Cag	p.E248Q	RWDD2A_ENST00000539997.1_Missense_Mutation_p.E194Q	NM_033411.3	NP_219479.2	Q9UIY3	RWD2A_HUMAN	RWD domain containing 2A	248										cervix(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	5		all_cancers(76;2.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00217)		BRCA - Breast invasive adenocarcinoma(397;0.045)		GTTACTCCTTGAGGCTCATGG	0.418000													15	93					0	0	1	0	0
SSTR5	6755	broad.mit.edu	37	16	1129719	1129719	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:1129719G>A	ENST00000293897.4	+	1	939	c.851G>A	c.(850-852)gGc>gAc	p.G284D	SSTR5_ENST00000397547.2_Missense_Mutation_p.G284D|SSTR5_ENST00000562758.1_Intron	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	284					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GCCTCCGCCGGCCTCTACTTC	0.617000													33	77					0	0	1	0	0
AURKA	6790	broad.mit.edu	37	20	54961341	54961341	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr20:54961341C>A	ENST00000395909.4	-	5	856	c.291G>T	c.(289-291)aaG>aaT	p.K97N	AURKA_ENST00000395915.3_Missense_Mutation_p.K97N|AURKA_ENST00000395907.1_Missense_Mutation_p.K97N|AURKA_ENST00000395911.1_Missense_Mutation_p.K97N|AURKA_ENST00000312783.6_Missense_Mutation_p.K97N|AURKA_ENST00000395913.3_Missense_Mutation_p.K97N|AURKA_ENST00000395914.1_Missense_Mutation_p.K97N|AURKA_ENST00000347343.2_Missense_Mutation_p.K97N|AURKA_ENST00000371356.2_Missense_Mutation_p.K97N	NM_198433.1	NP_940835.1	O14965	AURKA_HUMAN	aurora kinase A	97					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|lung(9)|ovary(2)|prostate(1)|skin(2)	22			Colorectal(105;0.202)			GCTGCTTGCTCTTTTGGGTGT	0.478000													22	213					1.22574e-08	1.29025e-08	1	1	0
MALAT1	378938	broad.mit.edu	37	11	65268685	65268685	+	RNA	SNP	A	A	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr11:65268685A>G	ENST00000534336.1	+	0	3453					NR_002819.2																						GGCGGGGGGGAGTTTTCAGTA	0.398000													7	40					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936206	4936206	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr11:4936206C>T	ENST00000322013.3	-	1	716	c.688G>A	c.(688-690)Gtg>Atg	p.V230M	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V230M(1)		autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGACAGCACGGTGCGCAGG	0.522000													17	66					0	0	1	0	0
HTR1B	3351	broad.mit.edu	37	6	78172432	78172432	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:78172432C>T	ENST00000369947.2	-	1	1058	c.689G>A	c.(688-690)cGc>cAc	p.R230H		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	230					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	TACGTAGATGCGGCCATAGAG	0.607000													16	72					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150817147	150817147	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:150817147G>A	ENST00000397238.2	+	8	1043	c.1043G>A	c.(1042-1044)cGg>cAg	p.R348Q	AGAP3_ENST00000479901.1_Intron|AGAP3_ENST00000335367.3_Missense_Mutation_p.R528Q|AGAP3_ENST00000473312.1_Missense_Mutation_p.R348Q|AGAP3_ENST00000463381.1_Missense_Mutation_p.R120Q	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	312	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						ATCAGCCAGCGGGAGCTGCGC	0.647000													22	84					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059461	9059461	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:9059461T>C	ENST00000397910.4	-	3	28188	c.27985A>G	c.(27985-27987)Agc>Ggc	p.S9329G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9331	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATGTTCTGCTAGAAGAGATG	0.498000													68	127					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197297889	197297889	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:197297889C>A	ENST00000260983.2	-	2	441	c.259G>T	c.(259-261)Gac>Tac	p.D87Y		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	87					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCACTGGGGTCCACCTCCTCT	0.463000													7	67					5.18039e-06	5.37226e-06	1	1	0
ZNF839	55778	broad.mit.edu	37	14	102805159	102805159	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr14:102805159G>C	ENST00000262236.5	+	6	1673	c.1318G>C	c.(1318-1320)Gag>Cag	p.E440Q	ZNF839_ENST00000559185.1_Missense_Mutation_p.E440Q|ZNF839_ENST00000558850.1_Missense_Mutation_p.E440Q|ZNF839_ENST00000442396.2_Missense_Mutation_p.E556Q|ZNF839_ENST00000420933.2_3'UTR	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	440						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						TCAGGTTGCTGAGTCATTAGG	0.458000													12	34					0	0	1	0	0
ANKRD1	27063	broad.mit.edu	37	10	92675321	92675321	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:92675321C>T	ENST00000371697.3	-	8	1076	c.828G>A	c.(826-828)gcG>gcA	p.A276A		NM_014391.2	NP_055206.2	Q15327	ANKR1_HUMAN	ankyrin repeat domain 1 (cardiac muscle)	276					cellular lipid metabolic process|defense response|signal transduction		DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|prostate(3)|skin(1)	27		Colorectal(252;0.0475)				TGTTGAGATCCGCGCCATACA	0.458000													7	54					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564100	140564100	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:140564100G>A	ENST00000361016.2	+	1	3121	c.1966G>A	c.(1966-1968)Gcc>Acc	p.A656T		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		656	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.A656T(1)		breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGGCCACCGCCACGCTGCA	0.706000													75	67					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143396416	143396416	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr8:143396416C>T	ENST00000519651.1	-	6	465	c.362G>A	c.(361-363)cGg>cAg	p.R121Q	TSNARE1_ENST00000520166.1_Missense_Mutation_p.R340Q|TSNARE1_ENST00000518928.1_5'UTR|TSNARE1_ENST00000524325.1_Missense_Mutation_p.R340Q|TSNARE1_ENST00000307180.3_Missense_Mutation_p.R341Q			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	341					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGTTTTCAGCCGGTCCAGCTG	0.652000													4	85					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150901065	150901065	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:150901065G>A	ENST00000261800.5	-	18	11101	c.11089C>T	c.(11089-11091)Cag>Tag	p.Q3697*		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3697					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTAGCTCCTGAAACTCGTAG	0.582000													59	51					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087372	47087372	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:47087372G>C	ENST00000374312.1	+	3	1008	c.589G>C	c.(589-591)Gat>Cat	p.D197H	NPY4R_ENST00000395716.1_Missense_Mutation_p.D197H	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		GTTCCTGGCGGATAAGGTGGT	0.582000													18	178					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204032068	204032068	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:204032068C>T	ENST00000449802.1	+	37	6228	c.5895C>T	c.(5893-5895)ctC>ctT	p.L1965L		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1965							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ACTACTTTCTCAATTTCAAAA	0.383000													62	80					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210183	28210183	+	Silent	SNP	A	A	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr21:28210183A>G	ENST00000284984.2	-	9	3073	c.2619T>C	c.(2617-2619)ggT>ggC	p.G873G		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	873	TSP type-1 2.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		TTCTCTGCCAACCCAATTCAC	0.478000													16	113					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404587	10404587	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:10404587G>A	ENST00000226207.5	-	27	3672	c.3578C>T	c.(3577-3579)gCg>gTg	p.A1193V	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1193						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CAGGGTGGCCGCCGTGGCTTC	0.577000													26	151					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51950210	51950210	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr13:51950210C>A	ENST00000311234.4	-	13	2175	c.1703G>T	c.(1702-1704)cGc>cTc	p.R568L	INTS6_ENST00000490542.1_Missense_Mutation_p.R252L|INTS6_ENST00000425000.1_Missense_Mutation_p.R136L|INTS6_ENST00000463928.1_Intron|INTS6_ENST00000497989.1_Missense_Mutation_p.R390L|INTS6_ENST00000398119.2_Missense_Mutation_p.R555L	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	568					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		CAGAAATCTGCGAGTGCTCTT	0.338000													18	43					2.35188e-11	2.51346e-11	1	1	0
CYB5R3	1727	broad.mit.edu	37	22	43024193	43024193	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr22:43024193C>T	ENST00000361740.4	-	5	526	c.527G>A	c.(526-528)cGg>cAg	p.R176Q	CYB5R3_ENST00000407623.3_Missense_Mutation_p.R120Q|CYB5R3_ENST00000407332.1_Missense_Mutation_p.R120Q|CYB5R3_ENST00000402438.1_Missense_Mutation_p.R120Q|CYB5R3_ENST00000396303.3_Missense_Mutation_p.R120Q|CYB5R3_ENST00000352397.5_Missense_Mutation_p.R143Q	NM_001171660.1	NP_001165131.1	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3	143					blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity	p.R120Q(1)		kidney(2)|large_intestine(1)|lung(2)|skin(1)	6					NADH(DB00157)	ACTGGGGCCCCGGAACTCAAT	0.562000													13	210					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103706	53103706	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:53103706T>G	ENST00000408890.4	+	1	358	c.342T>G	c.(340-342)tgT>tgG	p.C114W		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	114										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						ACCTCTCCTGTGCCTGGGAGG	0.721000													4	82					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154802023	154802023	+	Nonsense_Mutation	SNP	C	C	T	rs150836510		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:154802023C>T	ENST00000460393.1	+	2	187	c.67C>T	c.(67-69)Cga>Tga	p.R23*	MME_ENST00000493237.1_Nonsense_Mutation_p.R23*|MME_ENST00000492661.1_Nonsense_Mutation_p.R23*|MME_ENST00000360490.2_Nonsense_Mutation_p.R23*|MME_ENST00000382989.3_Nonsense_Mutation_p.R23*|MME_ENST00000462745.1_Nonsense_Mutation_p.R23*	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	23					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.R23*(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GAAGAAACAGCGATGGACTCC	0.433000													20	202					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18160272	18160272	+	Missense_Mutation	SNP	C	C	A	rs145813372		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:18160272C>A	ENST00000327031.4	-	2	350	c.125G>T	c.(124-126)cGc>cTc	p.R42L	FLII_ENST00000545457.2_Missense_Mutation_p.R42L|FLII_ENST00000584444.1_5'UTR|FLII_ENST00000579294.1_Missense_Mutation_p.R31L|FLII_ENST00000379450.4_Missense_Mutation_p.R11L|FLII_ENST00000578558.1_Missense_Mutation_p.R42L	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	42	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					GAGGCCAGTGCGGTTCAGCTT	0.652000													6	15					0.00198382	0.00199809	1	1	0
MTO1	25821	broad.mit.edu	37	6	74190513	74190513	+	Silent	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:74190513G>A	ENST00000498286.1	+	7	1522	c.1245G>A	c.(1243-1245)gaG>gaA	p.E415E	MTO1_ENST00000370300.4_Silent_p.E440E|MTO1_ENST00000370305.1_Silent_p.E366E|MTO1_ENST00000415954.2_Silent_p.E415E			Q9Y2Z2	MTO1_HUMAN	mitochondrial tRNA translation optimization 1	440					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)	27						CTGGTTATGAGGAAGCTGCAG	0.393000													18	42					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91652205	91652205	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:91652205G>C	ENST00000359028.2	+	15	4291	c.4066G>C	c.(4066-4068)Gaa>Caa	p.E1356Q	AKAP9_ENST00000356239.3_Missense_Mutation_p.E1344Q|AKAP9_ENST00000358100.2_Missense_Mutation_p.E1356Q			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1356					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCAAGAATTAGAAAGCCTCAT	0.343000			T	BRAF	papillary thyroid								17	31					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30593997	30593997	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:30593997T>A	ENST00000395216.2	-	3	1261	c.1102A>T	c.(1102-1104)Agg>Tgg	p.R368W	AC002310.7_ENST00000492040.1_RNA|AC002310.7_ENST00000486926.1_RNA|ZNF785_ENST00000470110.1_Missense_Mutation_p.R353W	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						CACGCGCGCCTCTCGCTGCAG	0.637000													37	99					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119575875	119575875	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:119575875C>A	ENST00000235521.4	-	6	768	c.742G>T	c.(742-744)Gtg>Ttg	p.V248L	WARS2_ENST00000537870.1_Missense_Mutation_p.V154L|WARS2_ENST00000369426.5_3'UTR	NM_015836.3|NM_201263.2	NP_056651.1|NP_957715.1	Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	248					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	AATTTCTGCACTATCTCCTCT	0.552000													38	103					6.03168e-27	7.0961e-27	1	1	0
TRIM58	25893	broad.mit.edu	37	1	248039556	248039556	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:248039556G>T	ENST00000366481.3	+	6	1274	c.1226G>T	c.(1225-1227)cGc>cTc	p.R409L	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	409	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAAAGTCCTCGCTGCATTGGG	0.478000													56	131					5.39261e-20	6.13793e-20	1	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971096	21971096	+	Nonsense_Mutation	SNP	C	C	A	rs121913384		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:21971096C>A	ENST00000304494.5	-	2	532	c.262G>T	c.(262-264)Gag>Tag	p.E88*	CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.E37*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.E37*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.E88*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.E88*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.E37*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.G102V|CDKN2A_ENST00000530628.2_Missense_Mutation_p.G102V|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.E88*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.G143V|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.E37*|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.E37*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	88			E -> D (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.E88*(15)|p.E88K(3)|p.H83fs*2(2)|p.D84_F90del(1)|p.0(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.G143V(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.V82_E88del(1)|p.E87K(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGGAAGCCCTCCCGGGCAGCG	0.756000	E88*(CAL33_UPPER_AERODIGESTIVE_TRACT)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			17	23					1.40151e-16	1.55723e-16	1	1	0
TSPAN31	6302	broad.mit.edu	37	12	58139630	58139630	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr12:58139630C>T	ENST00000547992.1	+	2	298	c.166C>T	c.(166-168)Ctt>Ttt	p.L56F	TSPAN31_ENST00000547472.1_Intron|TSPAN31_ENST00000553221.1_3'UTR|TSPAN31_ENST00000257910.3_Missense_Mutation_p.L56F			Q12999	TSN31_HUMAN	tetraspanin 31	56					positive regulation of cell proliferation	integral to plasma membrane|membrane fraction				endometrium(1)|kidney(1)|lung(5)	7	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GGGAGTCTTCCTTCTCCTTAT	0.577000													15	91					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600974	29600974	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr13:29600974G>T	ENST00000431530.3	+	1	2227	c.2169G>T	c.(2167-2169)ttG>ttT	p.L723F		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	713	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GTTCCGGATTGATGGTGTCTG	0.468000													25	57					2.41591e-17	2.70582e-17	1	1	0
AURKC	6795	broad.mit.edu	37	19	57743153	57743153	+	Translation_Start_Site	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:57743153C>A	ENST00000598785.1	+	0	167				AURKC_ENST00000415300.2_Silent_p.A15A|AURKC_ENST00000448930.1_De_novo_Start_InFrame|AURKC_ENST00000599062.1_Silent_p.A31A|AURKC_ENST00000302804.7_Silent_p.A34A			Q9UQB9	AURKC_HUMAN	aurora kinase C						cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		gcagcccagcCATGTGAGTCC	0.587000													8	110					2.17888e-05	2.24296e-05	1	1	0
TECTA	7007	broad.mit.edu	37	11	121000526	121000526	+	Silent	SNP	C	C	T	rs148065839		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr11:121000526C>T	ENST00000392793.1	+	10	2818	c.2547C>T	c.(2545-2547)tgC>tgT	p.C849C	TECTA_ENST00000264037.2_Silent_p.C849C			O75443	TECTA_HUMAN	tectorin alpha	849	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGGGCTTGTGCGGCTTCTACA	0.547000													4	208					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10224527	10224527	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:10224527C>T	ENST00000428358.1	+	13	1732	c.1560C>T	c.(1558-1560)ccC>ccT	p.P520P	PPAN_ENST00000556468.1_Silent_p.L500L|P2RY11_ENST00000321826.4_Silent_p.L80L|PPAN-P2RY11_ENST00000393796.4_Silent_p.L500L	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		0					RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GCTCTGCGCCCTGACGCTGCC	0.687000											OREG0025230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	31					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49137075	49137075	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:49137075G>C	ENST00000306125.6	-	16	1731	c.1394C>G	c.(1393-1395)tCt>tGt	p.S465C	QARS_ENST00000414533.1_Missense_Mutation_p.S454C			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	465					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GAAGTAGGAAGAGCGTCTGGG	0.572000													7	59					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819166	20819166	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr22:20819166C>A	ENST00000328879.4	-	4	1247	c.1091G>T	c.(1090-1092)cGa>cTa	p.R364L	KLHL22_ENST00000440659.2_Missense_Mutation_p.R221L	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	364					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GGACTCTGCTCGAAATCCTTG	0.562000													35	115					6.29468e-14	6.83144e-14	1	1	0
LRP6	4040	broad.mit.edu	37	12	12274116	12274116	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr12:12274116T>C	ENST00000261349.4	-	23	4862	c.4786A>G	c.(4786-4788)Agc>Ggc	p.S1596G	BCL2L14_ENST00000396369.1_Intron|LRP6_ENST00000543091.1_Missense_Mutation_p.S1551G	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1596					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TGAGAATAGCTCCTCTCTGTG	0.547000													6	82					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120847933	120847933	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:120847933A>C	ENST00000263713.5	+	12	1098	c.884A>C	c.(883-885)cAg>cCg	p.Q295P	EPB41L5_ENST00000443902.2_Missense_Mutation_p.Q295P|EPB41L5_ENST00000443124.1_Missense_Mutation_p.Q295P|EPB41L5_ENST00000331393.4_Missense_Mutation_p.Q295P|EPB41L5_ENST00000452780.1_Missense_Mutation_p.Q295P	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	295	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						GGCAAAGAACAGGAACATACA	0.373000													7	94					0	0	1	0	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802793	31802793	+	Missense_Mutation	SNP	G	G	A	rs139497735	byFrequency	TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr21:31802793G>A	ENST00000334068.2	+	1	222	c.200G>A	c.(199-201)cGc>cAc	p.R67H		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	67	4 X 10 AA approximate repeats.					intermediate filament				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						TCCTGCTACCGCCCCAGGACC	0.617000													15	86					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													4	10					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6863455	6863455	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr4:6863455G>C	ENST00000307659.5	+	7	1801	c.1346G>C	c.(1345-1347)tGt>tCt	p.C449S	KIAA0232_ENST00000425103.1_Missense_Mutation_p.C449S	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	449							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						CATGGTCTTTGTATCAGCAAC	0.383000													22	46					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105883845	105883845	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:105883845T>A	ENST00000393359.2	-	12	3004	c.2578A>T	c.(2578-2580)Act>Tct	p.T860S	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.T860S			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	860					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						GCTTTTCAAGTCCGAGTGCCA	0.557000													17	87					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79746660	79746660	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr14:79746660G>T	ENST00000281127.7	+	1	905	c.26G>T	c.(25-27)cGg>cTg	p.R9L	NRXN3_ENST00000428277.2_Missense_Mutation_p.R9L|NRXN3_ENST00000557594.1_Missense_Mutation_p.R9L|NRXN3_ENST00000335750.5_Intron|NRXN3_ENST00000554719.1_Intron	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	9					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CACGCGAGACGGAGCCCTCCT	0.557000													61	191					8.81991e-31	1.04643e-30	1	1	0
PCDHB8	56128	broad.mit.edu	37	5	140558302	140558302	+	Silent	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:140558302C>G	ENST00000239444.2	+	1	932	c.687C>G	c.(685-687)gtC>gtG	p.V229V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		229	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.V229V(1)		NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGCTCAGGTCTACATTGAAG	0.512000													92	322					0	0	1	0	0
RASA4	10156	broad.mit.edu	37	7	102246402	102246402	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:102246402C>T	ENST00000262940.7	-	5	398	c.331G>A	c.(331-333)Gac>Aac	p.D111N	RP11-514P8.6_ENST00000519541.1_3'UTR|RASA4_ENST00000461209.1_Missense_Mutation_p.D39N|RASA4_ENST00000449970.2_Missense_Mutation_p.D111N|RASA4_ENST00000462172.1_Missense_Mutation_p.D39N	NM_006989.5	NP_008920.5	O43374	RASL2_HUMAN	RAS p21 protein activator 4	111					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytosol|intrinsic to internal side of plasma membrane	metal ion binding|Ras GTPase activator activity			lung(1)|prostate(1)|urinary_tract(1)	3						TCATCGGGGTCGACCTCCGTC	0.706000													3	30					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744247	70744247	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr8:70744247G>A	ENST00000260126.3	-	2	1368	c.662C>T	c.(661-663)cCc>cTc	p.P221L	SLCO5A1_ENST00000530307.1_Missense_Mutation_p.P221L|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.P221L|SLCO5A1_ENST00000528658.1_5'UTR	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	221						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GATCTGGTAGGGGGGCGAGAT	0.677000													19	32					0	0	1	0	0
BCL2A1	597	broad.mit.edu	37	15	80253470	80253470	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr15:80253470G>A	ENST00000267953.3	-	2	793	c.467C>T	c.(466-468)aCt>aTt	p.T156I	BCL2A1_ENST00000335661.6_3'UTR	NM_004049.3	NP_004040.1	Q16548	B2LA1_HUMAN	BCL2-related protein A1	156					anti-apoptosis|apoptosis	cytoplasm	protein binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	12						TTCTAGAAAAGTCATCCAGCC	0.353000													14	28					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71491772	71491772	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:71491772G>A	ENST00000296755.7	+	5	2888	c.2590G>A	c.(2590-2592)Gaa>Aaa	p.E864K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	864						microtubule|microtubule associated complex	structural molecule activity	p.E864K(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AATCGAAGACGAAGAGAAACT	0.493000													133	132					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516483	102516483	+	RNA	SNP	A	A	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr15:102516483A>T	ENST00000557932.1	+	0	1431																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						GCTCCATGACACCTTCCCCCC	0.632000													12	119					0	0	1	0	0
TMED6	146456	broad.mit.edu	37	16	69385576	69385576	+	Nonsense_Mutation	SNP	T	T	A	rs143433971	by1000genomes	TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr16:69385576T>A	ENST00000564737.1	-	1	57	c.58A>T	c.(58-60)Aag>Tag	p.K20*	TMED6_ENST00000288025.3_Silent_p.L27L|RP11-343C2.9_ENST00000563634.1_Intron																							CAGAGCCACTTAGAGGTTCTG	0.552000													48	153					0	0	1	0	0
HIST3H3	8290	broad.mit.edu	37	1	228612821	228612821	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr1:228612821T>A	ENST00000366696.1	-	1	205	c.206A>T	c.(205-207)cAg>cTg	p.Q69L		NM_003493.2	NP_003484.1	Q16695	H31T_HUMAN	histone cluster 3, H3	69					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(1)|lung(2)|prostate(2)|skin(1)	6		Prostate(94;0.0724)				CATCAGCCGCTGGAAGGGCAA	0.642000													66	161					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125618118	125618118	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:125618118G>A	ENST00000373670.1	-	13	3094	c.2494C>T	c.(2494-2496)Cat>Tat	p.H832Y	RC3H2_ENST00000357244.2_Missense_Mutation_p.H832Y|RC3H2_ENST00000423239.2_Missense_Mutation_p.H832Y			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	832						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGGGAAAGATGATCTTCTTCA	0.358000													19	52					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139393350	139393350	+	Splice_Site	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr9:139393350C>G	ENST00000277541.6	-	33	6256		c.e33+1			NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CTCGCGCTCACCCTGTTGTTC	0.622000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			37	130					0	0	1	0	0
FAM117A	81558	broad.mit.edu	37	17	47788765	47788765	+	Missense_Mutation	SNP	G	G	A	rs138923537		TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:47788765G>A	ENST00000240364.2	-	8	1293	c.1214C>T	c.(1213-1215)cCg>cTg	p.P405L	RP11-613C6.2_ENST00000512720.1_RNA|FAM117A_ENST00000513602.1_Missense_Mutation_p.P133L	NM_030802.3	NP_110429.1	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	405	Pro-rich.									haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	17						GGGAGATCCCGGGTTTGAGGG	0.647000													19	59					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56501368	56501368	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:56501368G>A	ENST00000370754.5	-	22	2947	c.2948C>T	c.(2947-2949)aCa>aTa	p.T983I	DST_ENST00000370769.4_Missense_Mutation_p.T805I|DST_ENST00000370765.6_Missense_Mutation_p.T479I|DST_ENST00000518935.1_Missense_Mutation_p.T479I|DST_ENST00000312431.6_Missense_Mutation_p.T805I|DST_ENST00000421834.2_Missense_Mutation_p.T805I|DST_ENST00000446842.2_Missense_Mutation_p.T479I|DST_ENST00000370788.2_Missense_Mutation_p.T805I|DST_ENST00000244364.6_Missense_Mutation_p.T479I|DST_ENST00000361203.3_Missense_Mutation_p.T805I			Q03001	DYST_HUMAN	dystonin	805					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAAATACGCTGTGTTCTCCTT	0.413000													26	75					0	0	1	0	0
RSU1P2	100133308	broad.mit.edu	37	10	45602470	45602470	+	RNA	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:45602470C>T	ENST00000423875.1	-	0	966																											TTGTGAGCTTCCCAATATCTG	0.403000													3	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9046079	9046079	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:9046079G>T	ENST00000397910.4	-	5	35755	c.35552C>A	c.(35551-35553)tCc>tAc	p.S11851Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11853	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGATGGGTGGAAAGTGGGGC	0.478000													59	72					4.17463e-26	4.8704e-26	1	1	0
TP53I11	9537	broad.mit.edu	37	11	44957116	44957116	+	Silent	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr11:44957116G>A	ENST00000533940.1	-	9	1036	c.432C>T	c.(430-432)ttC>ttT	p.F144F	TP53I11_ENST00000308212.5_Silent_p.F144F|TP53I11_ENST00000395648.3_Silent_p.F144F|TP53I11_ENST00000525680.1_Silent_p.F144F	NM_001258320.1	NP_001245249.1	O14683	P5I11_HUMAN	tumor protein p53 inducible protein 11	144					negative regulation of cell proliferation|response to stress	integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5						ACTCACCCAAGAACTGGACCC	0.582000													6	60					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													4	42					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176687017	176687017	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr5:176687017C>T	ENST00000439151.2	+	14	5039	c.4994C>T	c.(4993-4995)cCt>cTt	p.P1665L	NSD1_ENST00000354179.4_Missense_Mutation_p.P1396L|NSD1_ENST00000361032.4_Missense_Mutation_p.P1562L|NSD1_ENST00000347982.4_Missense_Mutation_p.P1396L	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1665					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GTCCGCTGTCCTGTGGCATAC	0.438000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			63	62					0	0	1	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19363248	19363248	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr8:19363248G>A	ENST00000454498.2	-	4	1111	c.98C>T	c.(97-99)gCc>gTc	p.A33V	CSGALNACT1_ENST00000522854.1_Missense_Mutation_p.A33V|CSGALNACT1_ENST00000311540.4_Missense_Mutation_p.A33V|CSGALNACT1_ENST00000544602.1_Missense_Mutation_p.A33V|CSGALNACT1_ENST00000332246.6_Missense_Mutation_p.A33V	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	33					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		TGGGGTGCAGGCCAACATGTA	0.617000													37	84					0	0	1	0	0
HDAC10	83933	broad.mit.edu	37	22	50684138	50684138	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr22:50684138C>G	ENST00000216271.5	-	19	2304	c.1952G>C	c.(1951-1953)aGa>aCa	p.R651T	HDAC10_ENST00000349505.4_Missense_Mutation_p.R631T|HDAC10_ENST00000448072.1_Missense_Mutation_p.R601T|HDAC10_ENST00000498366.1_5'UTR|MAPK12_ENST00000497036.1_5'UTR	NM_001159286.1|NM_032019.5	NP_001152758.1|NP_114408.3	Q969S8	HDA10_HUMAN	histone deacetylase 10	651					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)			endometrium(2)|kidney(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCTGCCCTCTCAGGTACAT	0.662000													4	43					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	100963310	100963310	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:100963310T>C	ENST00000193391.7	-	13	2052	c.1865A>G	c.(1864-1866)gAg>gGg	p.E622G		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	622					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AGCGCTCTTCTCTGATGAAGT	0.433000													17	195					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54385908	54385908	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:54385908G>T	ENST00000263431.3	+	1	442	c.160G>T	c.(160-162)Gac>Tac	p.D54Y	PRKCG_ENST00000540413.1_Missense_Mutation_p.D54Y|PRKCG_ENST00000536044.1_Missense_Mutation_p.D54Y	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	54					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCACTGCACCGACTTCATCTG	0.622000													20	63					3.51602e-12	3.78648e-12	1	1	0
ACAD11	84129	broad.mit.edu	37	3	132378464	132378464	+	Silent	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:132378464C>T	ENST00000264990.6	-	1	1103	c.132G>A	c.(130-132)ctG>ctA	p.L44L	ACAD11_ENST00000545291.1_5'UTR|ACAD11_ENST00000481970.2_Silent_p.L44L|UBA5_ENST00000356232.4_5'UTR|ACAD11_ENST00000355458.3_Silent_p.L44L|UBA5_ENST00000264991.4_Intron|ACAD11_ENST00000489991.1_5'UTR	NM_032169.4	NP_115545.3			acyl-CoA dehydrogenase family, member 11											breast(2)|endometrium(6)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	36						GGGCAATGGTCAGCGTAGCCT	0.537000											OREG0015804	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	86					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108412274	108412274	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr10:108412274C>T	ENST00000263054.6	-	18	2348	c.2341G>A	c.(2341-2343)Gta>Ata	p.V781I	SORCS1_ENST00000369698.1_Missense_Mutation_p.V316I|SORCS1_ENST00000344440.6_Missense_Mutation_p.V781I	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	781						integral to membrane	neuropeptide receptor activity|protein binding	p.V781L(2)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGTTCCCTTACGCCATCAGTG	0.493000													27	94					0	0	1	0	0
HNRNPD	3184	broad.mit.edu	37	4	83279847	83279847	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr4:83279847C>G	ENST00000313899.7	-	4	863	c.586G>C	c.(586-588)Gag>Cag	p.E196Q	HNRNPD_ENST00000543098.1_Missense_Mutation_p.E144Q|HNRNPD_ENST00000541060.1_Missense_Mutation_p.E42Q|HNRNPD_ENST00000353341.4_Missense_Mutation_p.E196Q|HNRNPD_ENST00000352301.4_Missense_Mutation_p.E177Q	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	196	RRM 2.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						CTTATTTTCTCTTCAGGTGTA	0.378000													33	49					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11833927	11833927	+	Translation_Start_Site	SNP	C	C	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:11833927C>T	ENST00000545749.1	-	0	514				ZNF823_ENST00000341191.6_Missense_Mutation_p.R141H|ZNF823_ENST00000440527.1_Intron			P16415	ZN823_HUMAN	zinc finger protein 823						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						GGCTTTCCCACGTTGTTTATG	0.438000										HNSCC(68;0.2)			23	143					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151868382	151868382	+	Silent	SNP	T	T	C			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:151868382T>C	ENST00000355193.2	-	40	9638	c.9420A>G	c.(9418-9420)gaA>gaG	p.E3140E	KMT2C_ENST00000262189.6_Silent_p.E3140E					lysine (K)-specific methyltransferase 2C																		GGTTCTGTCCTTCACTGTTCT	0.443000													3	12					0	0	1	0	0
STK39	27347	broad.mit.edu	37	2	169103872	169103892	+	In_Frame_Del	DEL	GCCGCCGCCGCTGTCACCGGG	GCCGCCGCCGCTGTCACCGGG	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr2:169103872_169103892delGCCGCCGCCGCTGTCACCGGG	ENST00000355999.4	-	1	759_779	c.54_74delCCCGGTGACAGCGGCGGCGGC	c.(52-75)gcg>gc	p.APVTAAAA18del		NM_013233.2	NP_037365.2	Q9UEW8	STK39_HUMAN	serine threonine kinase 39	18	Ala/Pro-rich.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	13						cggggccgccgccgccgccgctgtcaccggggccgccTGCT	0.814													7	12	---	---	---	---					
EPHA6	285220	broad.mit.edu	37	3	97251229	97251229	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr3:97251229delG	ENST00000389672.5	+	11	2266	c.2228delG	c.(2227-2229)ctfs	p.R743fs	EPHA6_ENST00000442602.2_Frame_Shift_Del_p.R109fs|EPHA6_ENST00000502694.1_Frame_Shift_Del_p.R135fs|EPHA6_ENST00000514100.1_Frame_Shift_Del_p.R135fs	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	648	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TGTAGTGGGCGTTTGAAGACA	0.388													12	172	---	---	---	---					
F13A1	2162	broad.mit.edu	37	6	6174921	6174921	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:6174921delG	ENST00000264870.3	-	12	1904	c.1639delC	c.(1639-1641)gtfs	p.R547fs		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	547					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.R547C(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ATGGTGTAACGGTTGTGGCTG	0.507													25	90	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939829	31939830	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:31939829_31939830insA	ENST00000375331.2	+	1	222_223	c.56_57insA	c.(55-57)gaafs	p.E19fs	STK19_ENST00000375333.2_Frame_Shift_Ins_p.E19fs|DOM3Z_ENST00000375349.3_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|DOM3Z_ENST00000337523.5_5'UTR	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	19						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						CAGTGGCGGGCAAACCCCTCCC	0.634													7	256	---	---	---	---					
RPF2	84154	broad.mit.edu	37	6	111329306	111329307	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr6:111329306_111329307delAG	ENST00000441448.2	+	7	551_552	c.459_460delAG	c.(457-462)acaafs	p.TE153fs		NM_032194.1	NP_115570.1	Q9H7B2	RPF2_HUMAN	ribosome production factor 2 homolog (S. cerevisiae)	153	Brix.					nucleolus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|ovary(2)	7						TCGATGTAACAGAAGATTATAG	0.332													8	66	---	---	---	---					
AP5Z1	9907	broad.mit.edu	37	7	4828533	4828533	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr7:4828533delC	ENST00000348624.4	+	13	1752	c.1658delC	c.(1657-1659)gcfs	p.A553fs	AP5Z1_ENST00000401897.1_Frame_Shift_Del_p.A553fs	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	553					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										GCCCAGTGTGCCCAGGCCGTG	0.692													19	69	---	---	---	---					
P2RX4	5025	broad.mit.edu	37	12	121670836	121670837	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr12:121670836_121670837insT	ENST00000337233.4	+	11	1389_1390	c.1081_1082insT	c.(1081-1083)gaafs	p.E361fs	P2RX4_ENST00000543171.1_Frame_Shift_Ins_p.E260fs|P2RX4_ENST00000359949.7_Frame_Shift_Ins_p.E377fs	NM_001261397.1|NM_001261398.1|NM_002560.2	NP_001248326.1|NP_001248327.1|NP_002551.2	Q99571	P2RX4_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 4	361					endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding			breast(1)|kidney(4)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCTCTACTGCATGAAGAAAAGA	0.495													138	296	---	---	---	---					
POU4F1	5457	broad.mit.edu	37	13	79176484	79176486	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr13:79176484_79176486delTGG	ENST00000377208.5	-	2	535_537	c.324_326delCCA	c.(322-327)cag>ca	p.HQ108del	RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000560209.2_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	108	Poly-His.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.H108delH(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		TTCGAGCGCCtggtggtggtggt	0.729													3	4	---	---	---	---					
TANC2	26115	broad.mit.edu	37	17	61345182	61345190	+	In_Frame_Del	DEL	ACGAATGCC	ACGAATGCC	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr17:61345182_61345190delACGAATGCC	ENST00000424789.2	+	7	889_897	c.885_893delACGAATGCC	c.(883-894)cta>ct	p.LRMP295del	TANC2_ENST00000389520.4_In_Frame_Del_p.LRMP295del|AC037445.1_ENST00000581421.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	295							binding	p.M297I(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						GAACTTCTCTACGAATGCCAAGACAGAGC	0.483													8	43	---	---	---	---					
YIPF2	78992	broad.mit.edu	37	19	11038362	11038364	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr19:11038362_11038364delGCT	ENST00000586748.1	-	4	393_395	c.221_223delAGC	c.(220-225)ccg>c	p.QP74del	YIPF2_ENST00000253031.2_In_Frame_Del_p.QP74del|YIPF2_ENST00000590329.1_In_Frame_Del_p.QP74del			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	74						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						CAGAATCCCGgctgctgctgctg	0.621													7	136	---	---	---	---					
BCRP7	100133163	broad.mit.edu	37	22	18843723	18843724	+	RNA	INS	-	-	A			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr22:18843723_18843724insA	ENST00000412938.1	+	0	2337																											AGGGGCACCCCACGGCCTGGAG	0.619													4	5	---	---	---	---					
EP300-AS1	101927279	broad.mit.edu	37	22	41585696	41585697	+	RNA	INS	-	-	T			TCGA-BA-A4IF-01A-11D-A25Y-08	TCGA-BA-A4IF-10A-01D-A25Y-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08d0d2a4-d35d-4d63-9027-0995f487d377	aa9e0b6f-0add-4de6-bae3-be1f4e19081d	g.chr22:41585696_41585697insT	ENST00000420537.1	-	0	223																											cctgcTGGCCATTTTTTTTTTC	0.490													2	4	---	---	---	---