Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADAM29	11086	broad.mit.edu	37	4	175898746	175898746	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:175898746A>T	ENST00000359240.3	+	5	2740	c.2070A>T	c.(2068-2070)ttA>ttT	p.L690F	ADAM29_ENST00000404450.4_Missense_Mutation_p.L690F|RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000514159.1_Missense_Mutation_p.L690F|ADAM29_ENST00000445694.1_Missense_Mutation_p.L690F	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	690					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGTTTATTTTATTATGTTGTC	0.343000													9	19					0	0	0.004482	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50463939	50463939	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:50463939G>A	ENST00000447370.2	-	2	420	c.330C>T	c.(328-330)ggC>ggT	p.G110G	SIGLEC11_ENST00000426971.2_Silent_p.G110G	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	110	Ig-like V-type.				cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AGCTCCCTTTGCCGGGATCCC	0.587000													11	87					0	0	0.016723	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738821	176738821	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:176738821G>T	ENST00000367662.3	+	16	5566	c.4402G>T	c.(4402-4404)Gac>Tac	p.D1468Y		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1468	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.D1468Y(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CGGTGTTCCCGACCCGTCTTT	0.507000													16	102					0.000308642	0.00032539	0.024245	1	0
NFE2L2	4780	broad.mit.edu	37	2	178096545	178096545	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:178096545G>C	ENST00000397062.3	-	5	1340	c.786C>G	c.(784-786)gaC>gaG	p.D262E	NFE2L2_ENST00000397063.4_Missense_Mutation_p.D246E|NFE2L2_ENST00000464747.1_Missense_Mutation_p.D246E|NFE2L2_ENST00000446151.2_Missense_Mutation_p.D239E	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	262					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTGGTTGGGGTCTTCTGTGG	0.403000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			10	41					0	0	0.008291	0	0
FANCD2	2177	broad.mit.edu	37	3	10122836	10122836	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:10122836A>G	ENST00000287647.3	+	31	3122	c.3029A>G	c.(3028-3030)cAa>cGa	p.Q1010R	FANCD2_ENST00000383806.1_Missense_Mutation_p.Q1010R|FANCD2_ENST00000419585.1_Missense_Mutation_p.Q1010R|FANCD2_ENST00000383807.1_Missense_Mutation_p.Q1010R	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1010					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGATCTGCCCAAGAAATTGTT	0.408000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	46					0	0	0.007413	0	0
RFX5	5993	broad.mit.edu	37	1	151316211	151316211	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:151316211G>T	ENST00000290524.4	-	9	881	c.703C>A	c.(703-705)Ctc>Atc	p.L235I	RFX5_ENST00000452671.2_Missense_Mutation_p.L235I|RFX5_ENST00000368870.2_Missense_Mutation_p.L235I|RFX5_ENST00000452513.2_Missense_Mutation_p.L195I	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	235						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGAGATGAGATGCTGCTGT	0.582000													35	110					2.20262e-25	2.79959e-25	0.013726	1	0
HLA-DMB	3109	broad.mit.edu	37	6	32906490	32906490	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:32906490G>A	ENST00000416244.2	-	2	502	c.308C>T	c.(307-309)cCc>cTc	p.P103L	HLA-DMB_ENST00000418107.2_Missense_Mutation_p.P103L|XXbac-BPG181M17.5_ENST00000429234.1_Missense_Mutation_p.P135L			P28068	DMB_HUMAN	major histocompatibility complex, class II, DM beta	103	Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						TCCCCAGAAGGGCTGGGTGTG	0.572000													25	77					0	0	0.018920	0	0
TRRAP	8295	broad.mit.edu	37	7	98608797	98608797	+	Silent	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:98608797C>A	ENST00000359863.4	+	70	11228	c.11019C>A	c.(11017-11019)acC>acA	p.T3673T	TRRAP_ENST00000355540.3_Silent_p.T3644T|TRRAP_ENST00000446306.3_Silent_p.T3662T	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3673	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGATGTTCACCATCCAGCTGG	0.537000													20	73					1.96895e-08	2.23147e-08	0.016522	1	0
SETD2	29072	broad.mit.edu	37	3	47162207	47162207	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:47162207C>G	ENST00000409792.3	-	3	3961	c.3919G>C	c.(3919-3921)Gat>Cat	p.D1307H		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GATCTTGGATCCCAGTAACCA	0.473000			"""N, F, S, Mis"""		clear cell renal carcinoma								10	31					0	0	0.013537	0	0
KEAP1	9817	broad.mit.edu	37	19	10597411	10597411	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:10597411T>C	ENST00000171111.5	-	6	2339	c.1792A>G	c.(1792-1794)Aca>Gca	p.T598A	KEAP1_ENST00000393623.2_Missense_Mutation_p.T598A	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGGCCCGATGTCATTCGGGTC	0.567000													47	44					0	0	0.014410	0	0
SLC23A2	9962	broad.mit.edu	37	20	4880210	4880210	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr20:4880210A>G	ENST00000379333.1	-	6	865	c.473T>C	c.(472-474)tTt>tCt	p.F158S	SLC23A2_ENST00000468355.1_5'UTR|SLC23A2_ENST00000338244.1_Missense_Mutation_p.F158S|SLC23A2_ENST00000424750.2_Missense_Mutation_p.F158S	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	158					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CCTGCATCCAAACGTTGTCTG	0.552000													71	176					0	0	0.014410	0	0
POTEE	445582	broad.mit.edu	37	2	131976382	131976382	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:131976382G>A	ENST00000356920.5	+	1	501	c.407G>A	c.(406-408)cGt>cAt	p.R136H	POTEE_ENST00000358087.5_Missense_Mutation_p.R136H|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	136							ATP binding										TACCACGTCCGTGGAGAAGAT	0.592000													29	78					0	0	0.023175	0	0
DCTN1	1639	broad.mit.edu	37	2	74592723	74592723	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:74592723G>A	ENST00000361874.3	-	25	3265	c.2948C>T	c.(2947-2949)gCt>gTt	p.A983V	DCTN1_ENST00000409240.1_Missense_Mutation_p.A946V|DCTN1_ENST00000409438.1_Missense_Mutation_p.A849V|DCTN1_ENST00000409868.1_Missense_Mutation_p.A966V|DCTN1_ENST00000394003.3_Missense_Mutation_p.A976V|DCTN1_ENST00000409567.3_Missense_Mutation_p.A963V|DCTN1_ENST00000407639.2_Missense_Mutation_p.A849V	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	983					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						ATCCTTGGCAGCACTGTCCAA	0.567000													3	63					0	0	0.004672	0	0
ATP2B4	493	broad.mit.edu	37	1	203682333	203682333	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:203682333G>C	ENST00000357681.5	+	14	3375	c.2252G>C	c.(2251-2253)cGg>cCg	p.R751P	ATP2B4_ENST00000367219.3_Missense_Mutation_p.R739P|ATP2B4_ENST00000367218.3_Missense_Mutation_p.R751P|ATP2B4_ENST00000391954.2_Missense_Mutation_p.R751P|ATP2B4_ENST00000341360.2_Missense_Mutation_p.R751P	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	751					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTAAGCTTCGGGTCCTGGCG	0.537000													26	110					0	0	0.024334	0	0
MAP1A	4130	broad.mit.edu	37	15	43821107	43821107	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr15:43821107G>A	ENST00000382031.1	+	5	8181	c.8150G>A	c.(8149-8151)cGg>cAg	p.R2717Q	MAP1A_ENST00000300231.5_Missense_Mutation_p.R2479Q|MAP1A_ENST00000399453.1_Missense_Mutation_p.R2479Q			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2479						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGAGGGGGGCGGCGCCGGGTA	0.622000													17	33					0	0	0.007413	0	0
CD5L	922	broad.mit.edu	37	1	157811469	157811469	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:157811469A>G	ENST00000368174.4	-	1	119	c.23T>C	c.(22-24)aTc>aCc	p.I8T	CD5L_ENST00000484609.1_Intron	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	8					apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTCACCAAGGATCAAGGAGAA	0.453000													5	25					0	0	0.014758	0	0
NOL8	55035	broad.mit.edu	37	9	95064013	95064013	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr9:95064013C>G	ENST00000545558.1	-	13	3487	c.2995G>C	c.(2995-2997)Gaa>Caa	p.E999Q	NOL8_ENST00000542053.1_Missense_Mutation_p.E931Q|NOL8_ENST00000442668.2_Missense_Mutation_p.E999Q|NOL8_ENST00000358855.4_Missense_Mutation_p.E931Q|NOL8_ENST00000535387.1_Missense_Mutation_p.E961Q			Q76FK4	NOL8_HUMAN	nucleolar protein 8	999					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TGGAATATTTCTTTCAGATCC	0.388000													5	11					0	0	0.014758	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685719	125685719	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:125685719G>A	ENST00000371126.1	-	1	1115	c.873C>T	c.(871-873)gcC>gcT	p.A291A		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	291										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						GTGCGCTCCCGGCTTTCCACA	0.607000													15	30					0	0	0.024245	0	0
BRSK1	84446	broad.mit.edu	37	19	55823324	55823324	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:55823324G>A	ENST00000309383.1	+	19	2502	c.2225G>A	c.(2224-2226)cGa>cAa	p.R742Q	BRSK1_ENST00000590333.1_Missense_Mutation_p.R758Q|BRSK1_ENST00000326848.7_Missense_Mutation_p.R437Q	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	742					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCCCACCCCGAAGCCTGCAG	0.697000													5	17					0	0	0.014758	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788292	140788292	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:140788292A>C	ENST00000520790.1	+	1	523	c.523A>C	c.(523-525)Aat>Cat	p.N175H	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAAACTCTAATCCTTATTT	0.388000													10	7					0	0	0.006214	0	0
TCEANC2	127428	broad.mit.edu	37	1	54562121	54562121	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:54562121C>T	ENST00000234827.1	+	5	802	c.602C>T	c.(601-603)aCg>aTg	p.T201M	TCEANC2_ENST00000371331.1_Missense_Mutation_p.T231M|TCEANC2_ENST00000498272.1_3'UTR	NM_153035.1	NP_694580.1	Q96MN5	TEAN2_HUMAN	transcription elongation factor A (SII) N-terminal and central domain containing 2	201	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|lung(3)|pancreas(1)	5						CCAGTCGGCACGTTTGTACAG	0.582000													7	53					0	0	0.003080	0	0
ZNF709	163051	broad.mit.edu	37	19	12575387	12575387	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:12575387C>A	ENST00000397732.3	-	4	1520	c.1349G>T	c.(1348-1350)tGt>tTt	p.C450F	ZNF709_ENST00000428311.1_Missense_Mutation_p.C450F|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						ACACTGTTTACATTCATAGGG	0.403000													27	82					4.87955e-14	5.7706e-14	0.027356	1	0
APOBEC3B	9582	broad.mit.edu	37	22	39387518	39387518	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:39387518A>G	ENST00000402182.3	+	6	960	c.905A>G	c.(904-906)cAc>cGc	p.H302R	APOBEC3B_ENST00000333467.3_Missense_Mutation_p.H302R|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.H277R			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	302					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					GAGAACACACACGTGAGACTG	0.597000													14	212					0	0	0.004990	0	0
COPS7B	64708	broad.mit.edu	37	2	232653363	232653363	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:232653363C>A	ENST00000373608.3	+	2	190	c.83C>A	c.(82-84)aCt>aAt	p.T28N	COPS7B_ENST00000409091.1_Intron|COPS7B_ENST00000410024.1_Missense_Mutation_p.T28N|COPS7B_ENST00000409295.1_Intron|COPS7B_ENST00000410017.1_Missense_Mutation_p.T28N|COPS7B_ENST00000350033.3_Missense_Mutation_p.T28N			Q9H9Q2	CSN7B_HUMAN	COP9 signalosome subunit 7B	28					cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)	8		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		TCAGCCCTCACTGCTCTCATA	0.498000													29	41					8.58068e-18	1.03272e-17	0.007291	1	0
BCRP7	100133163	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:18844766G>A	ENST00000412938.1	+	0	3016																											CAGCCTCTGAGGGCAGCAGTG	0.557000													3	39					0	0	0.004672	0	0
ZNF142	7701	broad.mit.edu	37	2	219510940	219510940	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:219510940T>A	ENST00000411696.2	-	6	2184	c.1405A>T	c.(1405-1407)Aag>Tag	p.K469*	ZNF142_ENST00000449707.1_Nonsense_Mutation_p.K469*			P52746	ZN142_HUMAN	zinc finger protein 142	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGTAGTGCTTCCACTTGGTG	0.517000													43	56					0	0	0.007835	0	0
USP15	9958	broad.mit.edu	37	12	62715344	62715344	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr12:62715344A>G	ENST00000280377.5	+	5	633	c.575A>G	c.(574-576)aAt>aGt	p.N192S	USP15_ENST00000353364.3_Missense_Mutation_p.N192S|USP15_ENST00000393654.3_Missense_Mutation_p.N192S|USP15_ENST00000312635.6_Missense_Mutation_p.N192S|USP15_ENST00000550632.1_3'UTR	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	192					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GAACCACTGAATAAACCAGAC	0.338000													8	19					0	0	0.004482	0	0
CSMD1	64478	broad.mit.edu	37	8	3432474	3432474	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:3432474G>A	ENST00000602557.1	-	11	1895	c.1340C>T	c.(1339-1341)cCg>cTg	p.P447L	CSMD1_ENST00000400186.3_Missense_Mutation_p.P447L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P446L|CSMD1_ENST00000539096.1_Missense_Mutation_p.P446L|CSMD1_ENST00000520002.1_Missense_Mutation_p.P447L|CSMD1_ENST00000542608.1_Missense_Mutation_p.P446L|CSMD1_ENST00000602723.1_Missense_Mutation_p.P447L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	447	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TACCTTGTCCGGGTCGGTGGT	0.522000													16	31					0	0	0.028581	0	0
RANBP10	57610	broad.mit.edu	37	16	67761784	67761784	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:67761784C>T	ENST00000317506.3	-	12	1605	c.1490G>A	c.(1489-1491)cGg>cAg	p.R497Q	RANBP10_ENST00000536251.1_Missense_Mutation_p.R268Q|RANBP10_ENST00000448631.2_Missense_Mutation_p.R471Q|RANBP10_ENST00000602677.1_Missense_Mutation_p.R527Q|RANBP10_ENST00000411657.2_Missense_Mutation_p.R410Q	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	497										endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		GAGCTGCCGCCGAGGATGCCT	0.622000													12	29					0	0	0.010729	0	0
STEAP4	79689	broad.mit.edu	37	7	87910314	87910314	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:87910314C>T	ENST00000380079.4	-	4	1166	c.1065G>A	c.(1063-1065)ggG>ggA	p.G355G	AC003991.3_ENST00000600908.1_RNA|STEAP4_ENST00000301959.5_Silent_p.G179G|AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000595121.1_RNA|AC003991.3_ENST00000447758.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	355	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					ACAGAAAAAACCCAAGTATTC	0.408000													19	34					0	0	0.006122	0	0
GCM1	8521	broad.mit.edu	37	6	52993147	52993147	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:52993147G>A	ENST00000259803.7	-	6	1379	c.1168C>T	c.(1168-1170)Ctc>Ttc	p.L390F		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	390						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					TAGGTGAAGAGAAAGGGGTCT	0.443000													13	269					0	0	0.013537	0	0
CCT6P1	643253	broad.mit.edu	37	7	65224177	65224177	+	RNA	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:65224177T>C	ENST00000442266.1	+	0	814																											CTCTTGCTTGTGGTGGGGTGG	0.398000													5	11					0	0	0.001984	0	0
CAMTA1	23261	broad.mit.edu	37	1	7798138	7798138	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:7798138C>T	ENST00000303635.7	+	16	3985	c.3778C>T	c.(3778-3780)Ctg>Ttg	p.L1260L	CAMTA1_ENST00000439411.2_Silent_p.L1260L	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCAGGAGAAGCTGCTTCCCAC	0.493000			T	WWTR1	epitheliod hemangioendothelioma								9	41					0	0	0.004482	0	0
NFATC2IP	84901	broad.mit.edu	37	16	28975123	28975123	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:28975123G>T	ENST00000320805.4	+	8	1274	c.1199G>T	c.(1198-1200)gGc>gTc	p.G400V	RP11-264B17.2_ENST00000569974.1_RNA|NFATC2IP_ENST00000568148.1_Missense_Mutation_p.G108V|NFATC2IP_ENST00000564978.1_Missense_Mutation_p.G121V	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	400	Ubiquitin-like.					cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						AAGCTTTCAGGCAGGGAGCTG	0.587000													9	29					0.000442599	0.000463027	0.006214	1	0
INPP4A	3631	broad.mit.edu	37	2	99160454	99160454	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:99160454C>T	ENST00000074304.5	+	11	1326	c.933C>T	c.(931-933)gaC>gaT	p.D311D	INPP4A_ENST00000523221.1_Silent_p.D311D|INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000409016.3_Silent_p.D311D|INPP4A_ENST00000409540.3_Silent_p.D311D|INPP4A_ENST00000545415.1_Silent_p.D311D|INPP4A_ENST00000409851.3_Silent_p.D311D	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	311					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						ACCTGACCGACCTCCATCAGT	0.587000													3	5					0	0	0.004672	0	0
FBXO24	26261	broad.mit.edu	37	7	100198322	100198322	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:100198322A>G	ENST00000241071.6	+	10	1865	c.1543A>G	c.(1543-1545)Atg>Gtg	p.M515V	FBXO24_ENST00000468962.1_Missense_Mutation_p.M503V|PCOLCE-AS1_ENST00000544873.1_RNA|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Missense_Mutation_p.M553V|FBXO24_ENST00000360609.2_3'UTR	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	515						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCGGGGGGATGGCCCAGGC	0.662000													3	50					0	0	0.004672	0	0
KIAA0922	23240	broad.mit.edu	37	4	154525199	154525199	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:154525199G>A	ENST00000409663.3	+	25	3084	c.3032G>A	c.(3031-3033)aGc>aAc	p.S1011N	KIAA0922_ENST00000440693.1_Missense_Mutation_p.S928N|KIAA0922_ENST00000409959.3_Missense_Mutation_p.S1012N	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1011						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CCCCTGGGCAGCTCACTGCCT	0.502000													13	67					0	0	0.016723	0	0
DSEL	92126	broad.mit.edu	37	18	65180850	65180850	+	Silent	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr18:65180850G>T	ENST00000310045.7	-	2	2499	c.1026C>A	c.(1024-1026)tcC>tcA	p.S342S	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	332						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AATTATAATTGGAATCTGCTA	0.363000													13	56					4.3838e-07	4.88686e-07	0.016723	1	0
NEFH	4744	broad.mit.edu	37	22	29879403	29879403	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:29879403C>T	ENST00000310624.6	+	2	956	c.923C>T	c.(922-924)aCa>aTa	p.T308I		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	308	Coil 2B.|Rod.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						AAGGTGAACACAGACGCTATG	0.597000													56	271					0	0	0.014410	0	0
PTPN6	5777	broad.mit.edu	37	12	7065324	7065324	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr12:7065324C>T	ENST00000456013.1	+	8	1106	c.864C>T	c.(862-864)atC>atT	p.I288I	PTPN6_ENST00000399448.1_Silent_p.I290I|PTPN6_ENST00000318974.9_Silent_p.I288I|PTPN6_ENST00000447931.2_Silent_p.I249I	NM_080549.3	NP_536859.1	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type 6	288	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|prostate(3)	18						GCCGAGTGATCCTGCAGGGAC	0.612000													14	34					0	0	0.020292	0	0
OR2M2	391194	broad.mit.edu	37	1	248344299	248344299	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:248344299A>G	ENST00000359682.2	+	1	1012	c.1012A>G	c.(1012-1014)Aaa>Gaa	p.K338E		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	338					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K338E(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTATGATGTCAAAATACTAGC	0.289000													23	114					0	0	0.012319	0	0
FAM71B	153745	broad.mit.edu	37	5	156590665	156590665	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:156590665G>A	ENST00000302938.4	-	2	706	c.611C>T	c.(610-612)gCa>gTa	p.A204V		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	204						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGAGCTCTGCAGCCTATAC	0.493000													18	53					0	0	0.007413	0	0
ECI2	10455	broad.mit.edu	37	6	4135788	4135788	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:4135788T>C	ENST00000380118.3	-	1	43	c.7A>G	c.(7-9)Atg>Gtg	p.M3V	RP3-400B16.4_ENST00000527831.1_RNA|ECI2_ENST00000413766.2_5'UTR|ECI2_ENST00000465828.1_5'UTR|ECI2_ENST00000361538.2_5'UTR			O75521	ECI2_HUMAN	enoyl-CoA delta isomerase 2	3					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	11						AAGTACGCCATCGCCATCCCT	0.731000													19	59					0	0	0.010504	0	0
CDH11	1009	broad.mit.edu	37	16	64984856	64984856	+	Silent	SNP	G	G	A	rs142957030		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:64984856G>A	ENST00000394156.3	-	12	2161	c.1708C>T	c.(1708-1710)Ctg>Ttg	p.L570L	CDH11_ENST00000268603.4_Silent_p.L570L|CDH11_ENST00000566827.1_Silent_p.L444L			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	570	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ACTATGGGCAGAAGGTACAAG	0.612000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			15	33					0	0	0.024245	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213436154	213436154	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:213436154C>T	ENST00000366960.3	+	14	3235	c.3085C>T	c.(3085-3087)Caa>Taa	p.Q1029*	RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543354.1_3'UTR|RPS6KC1_ENST00000366959.3_Nonsense_Mutation_p.Q1017*|RPS6KC1_ENST00000543470.1_Nonsense_Mutation_p.Q817*	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	1029	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTCACTCATTCAACAGGTAAT	0.418000													9	48					0	0	0.008291	0	0
SLC8A2	6543	broad.mit.edu	37	19	47941206	47941206	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:47941206G>A	ENST00000236877.6	-	7	2305	c.1910C>T	c.(1909-1911)gCc>gTc	p.A637V	SLC8A2_ENST00000542837.1_Missense_Mutation_p.A393V|SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Missense_Mutation_p.A100V	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	637					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CTCCTCCTCGGCTGTTAGCTT	0.567000													27	101					0	0	0.027356	0	0
FBXL4	26235	broad.mit.edu	37	6	99374830	99374830	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:99374830G>C	ENST00000369244.2	-	4	463	c.35C>G	c.(34-36)aCc>aGc	p.T12S	FBXL4_ENST00000229971.1_Missense_Mutation_p.T12S			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	12					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		ATAAAACATGGTCAGAACTGT	0.433000													15	75					0	0	0.024245	0	0
PEX6	5190	broad.mit.edu	37	6	42934376	42934376	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:42934376C>T	ENST00000304611.8	-	10	2050	c.1981G>A	c.(1981-1983)Gag>Aag	p.E661K	PEX6_ENST00000244546.4_Missense_Mutation_p.E661K	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	661					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			TCATCCTCCTCAGTCAAGCCA	0.597000													32	128					0	0	0.012213	0	0
ZFP57	346171	broad.mit.edu	37	6	29641487	29641487	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:29641487T>C	ENST00000376883.1	-	6	752	c.341A>G	c.(340-342)gAg>gGg	p.E114G	ZFP57_ENST00000376881.3_Missense_Mutation_p.E114G|ZFP57_ENST00000488757.1_Missense_Mutation_p.E134G			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	78			N -> S (in dbSNP:rs9461544).		DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						ACTAGTCCCCTCATCTCTCAG	0.512000													3	142					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179471858	179471858	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:179471858A>G	ENST00000589042.1	-	278	53695	c.53471T>C	c.(53470-53472)aTc>aCc	p.I17824T	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.I8884T|TTN_ENST00000460472.2_Missense_Mutation_p.I8759T|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I8951T|TTN_ENST00000342992.6_Missense_Mutation_p.I15256T|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.I16183T|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16183	Ig-like 104.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGACCTGTGATGTCACATTT	0.413000													24	130					0	0	0.021523	0	0
SIM1	6492	broad.mit.edu	37	6	100898154	100898154	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:100898154C>T	ENST00000369208.3	-	4	1119	c.337G>A	c.(337-339)Ggt>Agt	p.G113S	SIM1_ENST00000262901.4_Missense_Mutation_p.G113S			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	113	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGAGAAAGACCCAAGTGGACT	0.562000													32	107					0	0	0.015359	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256690	140256690	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:140256690C>G	ENST00000398631.2	+	1	1633	c.1633C>G	c.(1633-1635)Ctg>Gtg	p.L545V	PCDHA10_ENST00000307360.5_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCCGCCTCTGGGCAGCAA	0.697000													36	79					0	0	0.015359	0	0
ZNF302	55900	broad.mit.edu	37	19	35175566	35175566	+	Silent	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:35175566A>G	ENST00000505242.1	+	5	1118	c.624A>G	c.(622-624)aaA>aaG	p.K208K	ZNF302_ENST00000457781.2_Silent_p.K208K|ZNF302_ENST00000505365.2_3'UTR|ZNF302_ENST00000423823.2_Silent_p.K208K|ZNF302_ENST00000446502.2_Silent_p.K252K			Q9NR11	ZN302_HUMAN	zinc finger protein 302	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AATGTGGGAAAGCCTTTGGCA	0.438000													54	60					0	0	0.014410	0	0
SLC27A3	11000	broad.mit.edu	37	1	153749041	153749041	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:153749041G>T	ENST00000271857.2	+	2	1859	c.1099G>T	c.(1099-1101)Ggg>Tgg	p.G367W	SLC27A3_ENST00000484014.1_3'UTR|SLC27A3_ENST00000368661.3_Missense_Mutation_p.G286W			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	286					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAGAGCCATGGGGCTCCACCT	0.627000													4	152					1.23904e-05	1.32685e-05	0.014758	1	0
CAND2	23066	broad.mit.edu	37	3	12858258	12858258	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:12858258C>G	ENST00000456430.2	+	10	1868	c.1827C>G	c.(1825-1827)gaC>gaG	p.D609E	CAND2_ENST00000295989.5_Missense_Mutation_p.D516E	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	609					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TTGGGGATGACCTGGAGCCCA	0.647000													23	149					0	0	0.016522	0	0
AHNAK	79026	broad.mit.edu	37	11	62296954	62296954	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr11:62296954C>A	ENST00000378024.4	-	5	5209	c.4935G>T	c.(4933-4935)gaG>gaT	p.E1645D	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1645					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGAAATGCATCTCAGGCATCT	0.468000													71	224					8.73484e-25	1.09994e-24	0.014410	1	0
RTN3	10313	broad.mit.edu	37	11	63488185	63488185	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr11:63488185C>A	ENST00000377819.5	+	3	2365	c.2211C>A	c.(2209-2211)gaC>gaA	p.D737E	RTN3_ENST00000540798.1_Missense_Mutation_p.D625E|RTN3_ENST00000339997.4_Missense_Mutation_p.D718E|RTN3_ENST00000354497.4_Intron|RTN3_ENST00000341307.2_Intron|RTN3_ENST00000537981.1_Intron|RTN3_ENST00000356000.3_Intron	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	737					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						CATCTCTTGACTTAGAACAAG	0.423000													17	26					5.3912e-06	5.86563e-06	0.006122	1	0
APP	351	broad.mit.edu	37	21	27394285	27394285	+	Missense_Mutation	SNP	C	C	T	rs147485129		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr21:27394285C>T	ENST00000358918.3	-	6	935	c.736G>A	c.(736-738)Gag>Aag	p.E246K	APP_ENST00000440126.3_Missense_Mutation_p.E241K|APP_ENST00000359726.3_Missense_Mutation_p.E246K|APP_ENST00000474136.1_5'UTR|APP_ENST00000357903.3_Missense_Mutation_p.E246K|APP_ENST00000346798.3_Missense_Mutation_p.E246K|APP_ENST00000354192.3_Missense_Mutation_p.E190K|APP_ENST00000348990.5_Missense_Mutation_p.E246K|APP_ENST00000439274.2_Missense_Mutation_p.E190K|APP_ENST00000448388.2_Missense_Mutation_p.E211K	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	246	Asp/Glu-rich (acidic).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				tcatcgtcctcgtcatcatcg	0.502000													9	35					0	0	0.004482	0	0
ASPM	259266	broad.mit.edu	37	1	197072273	197072273	+	Silent	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:197072273C>A	ENST00000367409.4	-	18	6364	c.6108G>T	c.(6106-6108)gtG>gtT	p.V2036V	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	2036	IQ 14.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTCTTTTTCTCACTTTCATAC	0.338000													54	59					6.14515e-18	7.46197e-18	0.014410	1	0
OLFM3	118427	broad.mit.edu	37	1	102271700	102271700	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:102271700C>A	ENST00000370103.4	-	5	844	c.631G>T	c.(631-633)Gtc>Ttc	p.V211F	OLFM3_ENST00000338858.5_Missense_Mutation_p.V231F|OLFM3_ENST00000536598.1_3'UTR|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	231						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GATGTCTTGACTGTAACTGGG	0.428000													10	31					2.68362e-12	3.14631e-12	0.013537	1	0
CAMTA1	23261	broad.mit.edu	37	1	7798137	7798137	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:7798137G>A	ENST00000303635.7	+	16	3984	c.3777G>A	c.(3775-3777)aaG>aaA	p.K1259K	CAMTA1_ENST00000439411.2_Silent_p.K1259K	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GGCAGGAGAAGCTGCTTCCCA	0.498000			T	WWTR1	epitheliod hemangioendothelioma								9	41					0	0	0.004482	0	0
SDK1	221935	broad.mit.edu	37	7	4249658	4249658	+	Splice_Site	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:4249658C>T	ENST00000404826.2	+	38	5542	c.5401_splice	c.e38-1	p.A1801_splice	SDK1_ENST00000389531.3_Splice_Site_p.A1781_splice	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1801					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTCTCCCAGCCCCTGGGGCCC	0.522000													4	118					0	0	0.021553	0	0
DMD	1756	broad.mit.edu	37	X	31854842	31854842	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:31854842G>T	ENST00000357033.4	-	49	7399	c.7193C>A	c.(7192-7194)cCa>cAa	p.P2398Q	DMD_ENST00000474231.1_5'UTR|DMD_ENST00000378677.2_Missense_Mutation_p.P2394Q|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000359836.1_5'UTR|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000343523.2_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2398					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACCTTCACTGGCTGAGTGGC	0.423000													23	16					1.36565e-18	1.67322e-18	0.016522	1	0
SCAND3	114821	broad.mit.edu	37	6	28540656	28540656	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:28540656C>A	ENST00000452236.2	-	4	3627	c.3010G>T	c.(3010-3012)Gaa>Taa	p.E1004*		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1004					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						gcaagactttctcgatgaatg	0.323000													16	34					3.51602e-12	4.08699e-12	0.008871	1	0
CMPK1	51727	broad.mit.edu	37	1	47834266	47834266	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:47834266A>G	ENST00000371873.5	+	2	446	c.297A>G	c.(295-297)atA>atG	p.I99M	CMPK1_ENST00000450808.2_Intron	NM_001136140.1|NM_016308.2	NP_001129612.1|NP_057392.1	P30085	KCY_HUMAN	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	67					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|stomach(2)	8					Gemcitabine(DB00441)	CAGTTGAGATAACCATCAGTT	0.403000													8	24					0	0	0.003080	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939160	2939160	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:2939160G>A	ENST00000378404.2	+	1	1115	c.910G>A	c.(910-912)Ggc>Agc	p.G304S		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	304						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GCTGTCGGGGGGCACTACCCT	0.612000													24	53					0	0	0.016522	0	0
KLHL1	57626	broad.mit.edu	37	13	70549922	70549922	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr13:70549922G>A	ENST00000377844.4	-	2	1269	c.510C>T	c.(508-510)acC>acT	p.T170T	KLHL1_ENST00000545028.1_Intron	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	170					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGAATGGCCGGTTGATGACA	0.378000													3	30					0	0	0.004672	0	0
TMEM39B	55116	broad.mit.edu	37	1	32566231	32566231	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:32566231G>T	ENST00000427288.1	+	9	1439	c.959G>T	c.(958-960)tGt>tTt	p.C320F	TMEM39B_ENST00000373634.4_Intron|TMEM39B_ENST00000487305.1_Intron|TMEM39B_ENST00000336294.5_Intron			Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	0						integral to membrane				endometrium(2)|kidney(1)|lung(5)|ovary(1)|prostate(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GGGCAGGAATGTGATGTCATT	0.512000													20	10					8.81451e-21	1.09979e-20	0.008871	1	0
CNNM4	26504	broad.mit.edu	37	2	97427416	97427416	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:97427416G>A	ENST00000377075.2	+	1	778	c.680G>A	c.(679-681)cGc>cAc	p.R227H		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	227	DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						AAGGAGAGGCGCTATGCCCGC	0.592000													4	69					0	0	0.014758	0	0
FAM71B	153745	broad.mit.edu	37	5	156590666	156590666	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:156590666C>A	ENST00000302938.4	-	2	705	c.610G>T	c.(610-612)Gca>Tca	p.A204S		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	204						nucleus		p.A204P(1)		NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGAGCTCTGCAGCCTATACC	0.488000													18	51					1.33834e-09	1.54249e-09	0.007413	1	0
CALHM1	255022	broad.mit.edu	37	10	105218230	105218230	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:105218230G>A	ENST00000329905.5	-	1	415	c.279C>T	c.(277-279)ccC>ccT	p.P93P	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	93						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						GCAACACAGCGGGGTCCTTGG	0.642000													17	26					0	0	0.028581	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724915	38724915	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:38724915G>A	ENST00000342213.2	-	1	659	c.313C>T	c.(313-315)Ctg>Ttg	p.L105L		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	105	C-type lectin.					integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCGTTCTCCAGGGTGCAGTGG	0.692000													3	8					0	0	0.004672	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372351	74372351	+	RNA	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:74372351C>G	ENST00000429810.2	-	0	1845																											ACTGTTATCTCAAACTCTGTG	0.368000													13	55					0	0	0.016723	0	0
SDHAP1	255812	broad.mit.edu	37	3	195711466	195711466	+	RNA	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:195711466G>T	ENST00000427841.1	-	0	481					NR_003264.2																						GCCCATCACCGCGACCATGGC	0.582000													4	103					0.00024832	0.00026384	0.009096	1	0
CDC6	990	broad.mit.edu	37	17	38450241	38450241	+	Silent	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr17:38450241A>G	ENST00000209728.4	+	6	1347	c.876A>G	c.(874-876)aaA>aaG	p.K292K		NM_001254.3	NP_001245.1	Q99741	CDC6_HUMAN	cell division cycle 6	292					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	21						TGGACAGCAAAGGCCAGGATG	0.393000													24	79					0	0	0.018920	0	0
TTC37	9652	broad.mit.edu	37	5	94820469	94820469	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:94820469C>G	ENST00000358746.2	-	38	4310	c.4012G>C	c.(4012-4014)Gac>Cac	p.D1338H		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1338							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						CTTCCTGTGTCTATTAGACCA	0.348000													18	25					0	0	0.006122	0	0
COPA	1314	broad.mit.edu	37	1	160262334	160262334	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:160262334C>T	ENST00000241704.7	-	28	3129	c.2900G>A	c.(2899-2901)cGc>cAc	p.R967H	COPA_ENST00000368069.3_Missense_Mutation_p.R976H	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	967					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity	p.R976H(2)|p.R967H(2)		central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATAGGTTGTGCGGCCTCGGGC	0.502000													4	124					0	0	0.009096	0	0
MRPL39	54148	broad.mit.edu	37	21	26978860	26978860	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr21:26978860G>C	ENST00000307301.7	-	2	222	c.181C>G	c.(181-183)Cga>Gga	p.R61G	MRPL39_ENST00000352957.4_Missense_Mutation_p.R61G	NM_080794.3	NP_542984.2	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39	61						mitochondrial ribosome	nucleotide binding			endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	10						TTCTCAGTTCGGGGAGTTAAT	0.433000													10	40					0	0	0.006214	0	0
AXL	558	broad.mit.edu	37	19	41749592	41749592	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:41749592G>A	ENST00000301178.4	+	12	1707	c.1517G>A	c.(1516-1518)cGt>cAt	p.R506H	AXL_ENST00000593513.1_Missense_Mutation_p.R238H|AXL_ENST00000359092.3_Missense_Mutation_p.R497H	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	506						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						TCCTACAGTCGTCGGACCACT	0.562000													38	72					0	0	0.023175	0	0
MIR518B	574474	broad.mit.edu	37	19	54206072	54206072	+	RNA	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:54206072G>C	ENST00000385127.1	+	0	82					NR_030196.1																						TTTACGGTTTGAGTAAAGCAG	0.463000													7	31					0	0	0.001984	0	0
RAI1	10743	broad.mit.edu	37	17	17697704	17697704	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr17:17697704G>T	ENST00000353383.1	+	3	1911	c.1442G>T	c.(1441-1443)tGc>tTc	p.C481F	RAI1_ENST00000261641.6_Missense_Mutation_p.C481F	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	481						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		AGCCAGCACTGCAGCCCCGAA	0.652000													19	66					4.63292e-17	5.527e-17	0.008871	1	0
E2F7	144455	broad.mit.edu	37	12	77439832	77439832	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr12:77439832G>T	ENST00000322886.7	-	5	1050	c.815C>A	c.(814-816)cCc>cAc	p.P272H	E2F7_ENST00000416496.2_Missense_Mutation_p.P272H	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	272					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						GGGACAGTCGGGTTCAGAGAA	0.433000													12	34					0.000978159	0.00101549	0.010729	1	0
GCNT1	2650	broad.mit.edu	37	9	79117750	79117750	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr9:79117750C>T	ENST00000442371.1	+	3	1392	c.453C>T	c.(451-453)tgC>tgT	p.C151C	GCNT1_ENST00000376730.4_Silent_p.C151C|GCNT1_ENST00000536223.1_Silent_p.C151C|GCNT1_ENST00000444201.2_Silent_p.C151C	NM_001097634.1	NP_001091103.1	Q02742	GCNT1_HUMAN	glucosaminyl (N-acetyl) transferase 1, core 2	151	Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(11)|prostate(2)|urinary_tract(1)	30						ATTTCTATTGCATTCATGTGG	0.443000													22	35					0	0	0.010504	0	0
OR2H1	26716	broad.mit.edu	37	6	29429639	29429639	+	Silent	SNP	T	T	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:29429639T>A	ENST00000377136.1	+	4	558	c.93T>A	c.(91-93)acT>acA	p.T31T	OR2H1_ENST00000377132.1_Silent_p.T31T|OR2H1_ENST00000473369.1_Intron|OR2H1_ENST00000442615.1_Silent_p.T31T|OR2H1_ENST00000377133.1_Silent_p.T31T|OR2H1_ENST00000396792.2_Silent_p.T31T			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						TTGTCTTCACTTCCTACCTCT	0.522000													4	166					0	0	0.009096	0	0
PABPC4	8761	broad.mit.edu	37	1	40034520	40034520	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:40034520T>A	ENST00000372857.3	-	6	1622	c.830A>T	c.(829-831)aAa>aTa	p.K277I	RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000372856.3_Missense_Mutation_p.K277I|PABPC4_ENST00000372858.3_Missense_Mutation_p.K277I|PABPC4_ENST00000372862.3_Missense_Mutation_p.K277I	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	277					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AAATTTCCGTTTTAACTCTGC	0.418000													28	64					0	0	0.008361	0	0
LOC645752	645752	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													3	173					0	0	0.004672	0	0
SLC4A7	9497	broad.mit.edu	37	3	27477926	27477926	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:27477926C>A	ENST00000295736.5	-	5	585	c.515G>T	c.(514-516)gGa>gTa	p.G172V	SLC4A7_ENST00000435667.2_Missense_Mutation_p.G181V|SLC4A7_ENST00000454389.1_Missense_Mutation_p.G181V|SLC4A7_ENST00000440156.1_Missense_Mutation_p.G181V|SLC4A7_ENST00000425128.2_Missense_Mutation_p.G177V|SLC4A7_ENST00000428386.1_Missense_Mutation_p.G172V|SLC4A7_ENST00000445684.1_Missense_Mutation_p.G181V|SLC4A7_ENST00000388777.4_5'UTR|SLC4A7_ENST00000446700.1_Missense_Mutation_p.G177V|SLC4A7_ENST00000455077.1_Missense_Mutation_p.G177V|SLC4A7_ENST00000437179.1_Missense_Mutation_p.G177V	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	172						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						CATGACTGTTCCATTGAGGAT	0.398000													11	30					4.68919e-08	5.27049e-08	0.008291	1	0
ABCC10	89845	broad.mit.edu	37	6	43403844	43403844	+	Silent	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:43403844A>G	ENST00000244533.3	+	4	2009	c.1650A>G	c.(1648-1650)ttA>ttG	p.L550L	ABCC10_ENST00000372530.4_Intron	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	589	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GTGGTAGATTAGGAGCCCAAA	0.488000													3	151					0	0	0.009096	0	0
CDKN2A	1029	broad.mit.edu	37	9	21974678	21974678	+	Splice_Site	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr9:21974678T>C	ENST00000304494.5	-	1	419	c.150_splice	c.e1+1	p.Q50_splice	RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000530628.2_Intron|CDKN2A_ENST00000494262.1_Intron|CDKN2A_ENST00000498124.1_Splice_Site_p.Q50_splice|CDKN2A_ENST00000498628.2_Intron|CDKN2A_ENST00000579122.1_Splice_Site_p.Q50_splice|CDKN2A_ENST00000361570.3_Intron|CDKN2A_ENST00000579755.1_Intron|CDKN2A_ENST00000446177.1_Splice_Site_p.Q50_splice	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	50			Q -> R (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(25)|p.Q50R(1)|p.0(1)|p.V28_V51del(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCTACCCACCTGGATCGGCCT	0.682000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			94	81					0	0	0.014410	0	0
LRP11	84918	broad.mit.edu	37	6	150174158	150174158	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:150174158T>C	ENST00000239367.2	-	2	757	c.752A>G	c.(751-753)gAc>gGc	p.D251G	LRP11_ENST00000546019.1_5'UTR|LRP11_ENST00000367368.2_Missense_Mutation_p.D251G	NM_032832.5	NP_116221.3	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein 11	251	PKD.					integral to membrane	receptor activity			cervix(1)|kidney(5)|large_intestine(1)|lung(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CACTGACGGGTCCCCCTGCAG	0.542000													4	54					0	0	0.014758	0	0
SLC12A8	84561	broad.mit.edu	37	3	124906105	124906105	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:124906105G>A	ENST00000423114.2	-	4	452	c.453C>T	c.(451-453)atC>atT	p.I151I	SLC12A8_ENST00000393469.4_Silent_p.I122I|SLC12A8_ENST00000469902.1_Silent_p.I122I|SLC12A8_ENST00000314584.7_5'UTR			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	122					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						AGAGCAGCCCGATGGTGCCTC	0.627000													14	72					0	0	0.020292	0	0
LOC645752	645752	broad.mit.edu	37	15	78212618	78212618	+	RNA	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr15:78212618A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TGTAACCGCCACTGGAGGACC	0.562000													3	44					0	0	0.004672	0	0
FLRT2	23768	broad.mit.edu	37	14	86088851	86088851	+	Silent	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:86088851T>C	ENST00000330753.4	+	2	1760	c.993T>C	c.(991-993)tcT>tcC	p.S331S	FLRT2_ENST00000554746.1_Silent_p.S331S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	331	LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TCCCTTCATCTCTCAACGTGC	0.488000													38	216					0	0	0.017118	0	0
LCLAT1	253558	broad.mit.edu	37	2	30863047	30863047	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:30863047G>C	ENST00000309052.4	+	7	1016	c.807G>C	c.(805-807)gaG>gaC	p.E269D	LCLAT1_ENST00000491680.2_3'UTR|LCLAT1_ENST00000540623.1_Missense_Mutation_p.E231D|LCLAT1_ENST00000379509.3_Missense_Mutation_p.E231D	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	269					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						CTCAATCAGAGAAGCACCTCC	0.473000													51	63					0	0	0.014410	0	0
NDUFA3	4696	broad.mit.edu	37	19	54611775	54611775	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:54611775G>A	ENST00000391764.3	+	4	202	c.192G>A	c.(190-192)gaG>gaA	p.E64E	TFPT_ENST00000391757.1_Intron|TFPT_ENST00000391758.1_Intron|TFPT_ENST00000391759.1_Intron			O95167	NDUA3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	65					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)	2	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)				NADH(DB00157)	ACAGGATAGAGCTCAGCTCCC	0.592000													6	34					0	0	0.001984	0	0
VWA3B	200403	broad.mit.edu	37	2	98852910	98852910	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:98852910C>T	ENST00000477737.1	+	18	2690	c.2486C>T	c.(2485-2487)aCg>aTg	p.T829M		NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	829								p.T829M(1)		NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GAAAAGGTGACGCGAGAAGGA	0.423000													22	45					0	0	0.010504	0	0
PLD1	5337	broad.mit.edu	37	3	171394572	171394572	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:171394572G>A	ENST00000356327.5	-	17	2004	c.1934C>T	c.(1933-1935)tCt>tTt	p.S645F	PLD1_ENST00000351298.4_Missense_Mutation_p.S683F|PLD1_ENST00000340989.4_Missense_Mutation_p.S683F|PLD1_ENST00000342215.6_Silent_p.L574L	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	683	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity	p.S683F(1)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GTGGACTGCAGAGGCAATGTC	0.532000													8	81					0	0	0.004482	0	0
SSTR3	6753	broad.mit.edu	37	22	37603361	37603361	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:37603361C>T	ENST00000328544.3	-	2	1015	c.482G>A	c.(481-483)cGc>cAc	p.R161H	SSTR3_ENST00000402501.1_Missense_Mutation_p.R161H	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	161					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						GCTGACCGTGCGGGCCACCGG	0.682000													53	59					0	0	0.014410	0	0
UGT2B4	7363	broad.mit.edu	37	4	70360857	70360857	+	Splice_Site	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:70360857A>G	ENST00000305107.6	-	1	768		c.e1+1		UGT2B4_ENST00000506580.1_Intron|UGT2B4_ENST00000512583.1_Splice_Site|UGT2B4_ENST00000381096.3_Splice_Site	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4						estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						AAAGTTACTTACCTAGAACTT	0.333000													8	17					0	0	0.003080	0	0
EGFR	1956	broad.mit.edu	37	7	55210023	55210023	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:55210023G>C	ENST00000275493.2	+	2	310	c.133G>C	c.(133-135)Gaa>Caa	p.E45Q	EGFR_ENST00000454757.2_5'UTR|EGFR_ENST00000342916.3_Missense_Mutation_p.E45Q|EGFR_ENST00000442591.1_Missense_Mutation_p.E45Q|EGFR_ENST00000420316.2_Missense_Mutation_p.E45Q|EGFR_ENST00000344576.2_Missense_Mutation_p.E45Q|EGFR_ENST00000455089.1_Missense_Mutation_p.E45Q	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	45					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGGCACTTTTGAAGATCATTT	0.398000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			5	350					0	0	0.014758	0	0
ZNF185	7739	broad.mit.edu	37	X	152113985	152113985	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:152113985C>T	ENST00000535861.1	+	17	1527	c.1479C>T	c.(1477-1479)gtC>gtT	p.V493V	ZNF185_ENST00000370270.1_Silent_p.V224V|ZNF185_ENST00000539731.1_Silent_p.V464V|ZNF185_ENST00000370268.4_Silent_p.V461V|ZNF185_ENST00000324823.6_Silent_p.V229V|ZNF185_ENST00000449285.2_Silent_p.V462V|ZNF185_ENST00000318504.7_Silent_p.V402V|ZNF185_ENST00000318529.8_Silent_p.V240V	NM_001178106.1	NP_001171577.1	O15231	ZN185_HUMAN	zinc finger protein 185 (LIM domain)	461						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					AGCAACTTGTCAGACGAGAGA	0.607000													6	3					0	0	0.021553	0	0
PEAK1	79834	broad.mit.edu	37	15	77474216	77474216	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr15:77474216T>C	ENST00000560626.2	-	4	528	c.53A>G	c.(52-54)aAg>aGg	p.K18R	PEAK1_ENST00000312493.4_Missense_Mutation_p.K18R|PEAK1_ENST00000558305.1_Missense_Mutation_p.K18R			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	18					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										AAAGCAATTCTTGCATTCACC	0.408000													23	43					0	0	0.012319	0	0
XRN2	22803	broad.mit.edu	37	20	21312236	21312236	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr20:21312236A>G	ENST00000377191.3	+	7	709	c.614A>G	c.(613-615)gAa>gGa	p.E205G	XRN2_ENST00000430571.2_Missense_Mutation_p.E129G|XRN2_ENST00000539513.1_Missense_Mutation_p.E151G	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	205					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						GGTGAAGGAGAACATAAAATC	0.289000													16	36					0	0	0.004990	0	0
VENTX	27287	broad.mit.edu	37	10	135053283	135053283	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:135053283C>G	ENST00000325980.9	+	2	856	c.345C>G	c.(343-345)taC>taG	p.Y115*		NM_014468.2	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	115					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		ACCACCAGTACCTGAGCCCTC	0.662000													27	33					0	0	0.006320	0	0
PCGF5	84333	broad.mit.edu	37	10	93038049	93038049	+	Nonsense_Mutation	SNP	T	T	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:93038049T>G	ENST00000336126.5	+	10	979	c.747T>G	c.(745-747)taT>taG	p.Y249*	PCGF5_ENST00000543648.1_Nonsense_Mutation_p.Y249*	NM_001257101.1|NM_032373.4	NP_001244030.1|NP_115749.2	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)	12						TACTGCAGTATCGACCAAGAA	0.358000													4	24					0	0	0.009096	0	0
C16orf71	146562	broad.mit.edu	37	16	4793097	4793097	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:4793097A>C	ENST00000299320.5	+	5	1315	c.837A>C	c.(835-837)gaA>gaC	p.E279D	C16orf71_ENST00000590191.1_Missense_Mutation_p.E293D|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	279										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						CGGGACAAGAAGACAACCAGG	0.527000													28	52					0	0	0.006320	0	0
HLA-F	3134	broad.mit.edu	37	6	29692932	29692932	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:29692932G>C	ENST00000440587.2	+	4	740	c.381G>C	c.(379-381)caG>caC	p.Q127H	HLA-F_ENST00000259951.7_Missense_Mutation_p.Q245H|HLA-F_ENST00000334668.4_Missense_Mutation_p.Q245H|HLA-F_ENST00000434407.2_Intron|HLA-F_ENST00000376861.1_Missense_Mutation_p.Q245H			P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	245	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						GGGAGGAACAGACCCAGGACA	0.627000													14	44					0	0	0.020292	0	0
KYNU	8942	broad.mit.edu	37	2	143712382	143712382	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:143712382C>G	ENST00000264170.4	+	5	635	c.377C>G	c.(376-378)gCc>gGc	p.A126G	KYNU_ENST00000409512.1_Missense_Mutation_p.A126G|KYNU_ENST00000375773.2_Missense_Mutation_p.A126G	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	126					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTACAGGAGCCAATGAGAAA	0.299000													3	28					0	0	0.004672	0	0
ANKS3	124401	broad.mit.edu	37	16	4774826	4774826	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:4774826C>T	ENST00000304283.4	-	6	792	c.498G>A	c.(496-498)ccG>ccA	p.P166P	ANKS3_ENST00000450067.2_Intron|ANKS3_ENST00000585773.1_Silent_p.P93P|ANKS3_ENST00000592711.1_Silent_p.P59P|ANKS3_ENST00000446014.2_Silent_p.P37P	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	166										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						ATCCACATATCGGCTCCCTGC	0.488000													6	16					0	0	0.001984	0	0
PAQR8	85315	broad.mit.edu	37	6	52268767	52268767	+	Silent	SNP	C	C	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:52268767C>A	ENST00000442253.2	+	2	930	c.756C>A	c.(754-756)atC>atA	p.I252I	PAQR8_ENST00000360726.3_Silent_p.I252I	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	252					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					CCCTCCAGATCCTCTTCTTCC	0.577000													17	50					2.23348e-06	2.44963e-06	0.028581	1	0
LYST	1130	broad.mit.edu	37	1	235952058	235952058	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:235952058G>T	ENST00000389794.3	-	13	4805	c.4631C>A	c.(4630-4632)tCc>tAc	p.S1544Y	LYST_ENST00000536965.1_3'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.S1544Y			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1544					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CAACGCTTTGGATCCCAGTGA	0.403000													9	29					1.12685e-05	1.21628e-05	0.004482	1	0
CSTF2	1478	broad.mit.edu	37	X	100078983	100078983	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:100078983G>A	ENST00000415585.2	+	5	575	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	CSTF2_ENST00000372972.2_Missense_Mutation_p.E185K|CSTF2_ENST00000486615.1_Intron			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	185	Interactions with CSTF3 and SYMPK.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						TGTGGATCCGGAAATTGCCCT	0.468000													23	45					0	0	0.014323	0	0
SLC35B4	84912	broad.mit.edu	37	7	133979789	133979789	+	Silent	SNP	G	G	A			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:133979789G>A	ENST00000378509.4	-	10	1091	c.792C>T	c.(790-792)tgC>tgT	p.C264C	SLC35B4_ENST00000466599.1_Intron	NM_032826.4	NP_116215.1	Q969S0	S35B4_HUMAN	solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4	264						Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			large_intestine(1)|lung(2)|skin(1)|stomach(1)	5						TGAGGGAGGCGCATTCTGTGG	0.537000													7	377					0	0	0.001984	0	0
SACS	26278	broad.mit.edu	37	13	23942586	23942586	+	Silent	SNP	G	G	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr13:23942586G>C	ENST00000382298.3	-	5	888	c.300C>G	c.(298-300)ctC>ctG	p.L100L	SACS_ENST00000382292.3_Silent_p.L100L|SACS_ENST00000402364.1_5'UTR	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	100					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAATGTCCTTGAGAAAATCAA	0.373000													5	13					0	0	0.014758	0	0
ADHFE1	137872	broad.mit.edu	37	8	67372555	67372555	+	Missense_Mutation	SNP	G	G	A	rs144952353		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:67372555G>A	ENST00000396623.3	+	13	1206	c.1175G>A	c.(1174-1176)cGc>cAc	p.R392H	ADHFE1_ENST00000415254.1_Missense_Mutation_p.R344H|C8orf46_ENST00000482608.2_3'UTR|ADHFE1_ENST00000496501.1_3'UTR	NM_144650.2	NP_653251.2	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	392					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding	p.R344H(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	29		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			GCCGACACCCGCACTGCCAGG	0.517000											OREG0018808	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	155					0	0	0.009096	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													5	58					0	0	0.021553	0	0
FUBP1	8880	broad.mit.edu	37	1	78430374	78430374	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:78430374C>T	ENST00000370767.1	-	10	881	c.794G>A	c.(793-795)cGg>cAg	p.R265Q	FUBP1_ENST00000370768.2_Missense_Mutation_p.R265Q|FUBP1_ENST00000436586.2_Missense_Mutation_p.R286Q			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	265					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						ATACTCATTCCGAACTTCTCT	0.353000			"""F, N"""		oligodendroglioma								17	57					0	0	0.004990	0	0
TBCK	93627	broad.mit.edu	37	4	107016738	107016738	+	Silent	SNP	T	T	G			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:107016738T>G	ENST00000273980.4	-	26	2919	c.2472A>C	c.(2470-2472)gcA>gcC	p.A824A	TBCK_ENST00000432496.2_Silent_p.A824A|TBCK_ENST00000361687.4_Silent_p.A761A|TBCK_ENST00000394708.2_Silent_p.A824A|TBCK_ENST00000394706.3_Silent_p.A785A			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	824	Rhodanese.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						GCTCCCCTTCTGCAGTGAAGG	0.468000													11	45					0	0	0.016723	0	0
EXT1	2131	broad.mit.edu	37	8	118847731	118847731	+	Silent	SNP	A	A	T			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:118847731A>T	ENST00000378204.2	-	3	1922	c.1116T>A	c.(1114-1116)atT>atA	p.I372I		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	372					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			GGTTCCAATTAATCACTTCAG	0.507000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				4	94					0	0	0.014758	0	0
IDE	3416	broad.mit.edu	37	10	94294475	94294475	+	Silent	SNP	T	T	C			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:94294475T>C	ENST00000265986.6	-	3	407	c.351A>G	c.(349-351)ggA>ggG	p.G117G		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	117					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTTCTTTGTTCCCAAAAAAA	0.348000													28	36					0	0	0.006320	0	0
ATP8B2	57198	broad.mit.edu	37	1	154303375	154303378	+	Frame_Shift_Del	DEL	ACTT	ACTT	-			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:154303375_154303378delACTT	ENST00000368489.3	+	4	274_277	c.274_277delACTT	c.(274-279)acfs	p.TY92fs	ATP8B2_ENST00000368487.3_Frame_Shift_Del_p.TY59fs|ATP8B2_ENST00000341822.2_Frame_Shift_Del_p.TY78fs|ATP8B2_ENST00000426445.1_3'UTR	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	78					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGTTGCCAACACTTACTTCCTGTT	0.461													7	49	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187628726	187628732	+	Frame_Shift_Del	DEL	CAGTTTT	CAGTTTT	-			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:187628726_187628732delCAGTTTT	ENST00000441802.2	-	2	2459_2465	c.2250_2256delAAAACTG	c.(2248-2256)ggfs	p.GKL750fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	750	Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAGCATAGACCAGTTTTCCATTGAAGC	0.425										HNSCC(5;0.00058)			58	32	---	---	---	---					
RP11-941H19.3	0	broad.mit.edu	37	8	81213768	81213768	+	RNA	DEL	C	C	-			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:81213768delC	ENST00000522044.1	+	0	404																											TTTTGGGACGCCCCCCCTCAC	0.542													13	11	---	---	---	---					
ZIC2	7546	broad.mit.edu	37	13	100634394	100634396	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr13:100634394_100634396delGCG	ENST00000376335.3	+	1	369_371	c.76_78delGCG	c.(76-78)del	p.A33del		NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	33	Poly-Ala.				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCACTccgccgcggcggcggcgg	0.759													2	4	---	---	---	---					
ARHGAP5	394	broad.mit.edu	37	14	32560503	32560516	+	Frame_Shift_Del	DEL	AGAGAAGTTCAGGC	AGAGAAGTTCAGGC	-			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:32560503_32560516delAGAGAAGTTCAGGC	ENST00000345122.3	+	2	943_956	c.628_641delAGAGAAGTTCAGGC	c.(628-642)afs	p.REVQA210fs	ARHGAP5_ENST00000556611.1_Frame_Shift_Del_p.REVQA210fs|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000539826.2_Frame_Shift_Del_p.REVQA210fs|ARHGAP5_ENST00000432921.1_Frame_Shift_Del_p.REVQA210fs	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	210					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TCATTATCTTAGAGAAGTTCAGGCATTTGCTTCA	0.322													9	58	---	---	---	---					
TMEM121	80757	broad.mit.edu	37	14	105996050	105996052	+	In_Frame_Del	DEL	GCC	GCC	-	rs5811180		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:105996050_105996052delGCC	ENST00000392519.2	+	2	1043_1045	c.879_881delGCC	c.(877-882)gtg>gt	p.VP293del	TMEM121_ENST00000431372.1_In_Frame_Del_p.VP293del	NM_025268.2	NP_079544.1	Q9BTD3	TM121_HUMAN	transmembrane protein 121	293	Pro-rich.					integral to membrane				endometrium(2)|lung(1)	3		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)		GCAACTCGGTgccgccgccgccg	0.768													4	3	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578180	7578181	+	Frame_Shift_Ins	INS	-	-	T	rs138983188		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr17:7578180_7578181insT	ENST00000420246.2	-	6	800_801	c.668_669insA	c.(667-669)cgafs	p.R223fs	TP53_ENST00000455263.2_Frame_Shift_Ins_p.R223fs|TP53_ENST00000413465.2_Frame_Shift_Ins_p.R223fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.R223fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.R223fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.R223fs|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	223	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in a sporadic cancer; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in a sporadic cancer; somatic mutation).|P -> S (in a sporadic cancer; somatic mutation).|P -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(12)|p.0?(8)|p.P223P(4)|p.P223L(4)|p.P223H(2)|p.Y220_P223delYEPP(1)|p.E224fs*4(1)|p.E224fs*5(1)|p.V218_E224delVPYEPPE(1)|p.P223R(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCAGACCTCAGGCGGCTCATA	0.540		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	20	---	---	---	---					
ANKRD20A5P	440482	broad.mit.edu	37	18	14183628	14183628	+	RNA	DEL	A	A	-			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr18:14183628delA	ENST00000581935.1	+	0	501																				lung(3)	3						ACAGTTTCCTAAAAAGTCCTG	0.378													19	114	---	---	---	---					
CYP2D7	1564	broad.mit.edu	37	22	42537119	42537120	+	RNA	INS	-	-	A	rs142656198	by1000genomes	TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:42537119_42537120insA	ENST00000435101.1	-	0	296				CYP2D7P1_ENST00000358097.4_RNA|CYP2D7P1_ENST00000433992.1_RNA																endometrium(1)	1						GGGCTACCACCGGGGCTGATGC	0.614													4	6	---	---	---	---					
SRPX	8406	broad.mit.edu	37	X	38079976	38079978	+	In_Frame_Del	DEL	GCA	GCA	-	rs72445954		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:38079976_38079978delGCA	ENST00000378533.3	-	1	174_176	c.68_70delTGC	c.(67-72)cgc>c	p.LR23del	SRPX_ENST00000432886.2_In_Frame_Del_p.LR23del|SRPX_ENST00000343800.6_Intron|TM4SF2_ENST00000465127.1_Intron|SRPX_ENST00000544439.1_In_Frame_Del_p.LR23del|SRPX_ENST00000538295.1_In_Frame_Del_p.LR23del	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane		p.L23delL(2)		autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						GGCGGGACGCgcagcagcagcag	0.729											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	6	---	---	---	---