Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HMX3	340784	broad.mit.edu	37	10	124896943	124896943	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:124896943G>A	ENST00000357878.5	+	2	859	c.770G>A	c.(769-771)cGa>cAa	p.R257Q		NM_001105574.1	NP_001099044.1	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	257					cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity			lung(4)	4		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		AGCTCGGAGCGAGCCGGCCTG	0.647000													12	65					0	0	1	0	0
MRPL20	55052	broad.mit.edu	37	1	1342362	1342362	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:1342362G>A	ENST00000482352.1	-	2	197	c.125C>T	c.(124-126)gCg>gTg	p.A42V	MRPL20_ENST00000344843.7_Missense_Mutation_p.A42V			Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20	42							protein binding|rRNA binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGTTCTGACCGCCAACCTGTA	0.602000													6	422					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99161197	99161197	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:99161197A>G	ENST00000370189.5	+	6	935	c.571A>G	c.(571-573)Aac>Gac	p.N191D	SNX7_ENST00000529992.1_Missense_Mutation_p.N200D|SNX7_ENST00000306121.3_Missense_Mutation_p.N255D			Q9UNH6	SNX7_HUMAN	sorting nexin 7	191					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		GGAAATGAATAACTTTATTGA	0.383000													23	113					0	0	1	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993723	45993723	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr21:45993723G>A	ENST00000400374.3	+	1	118	c.88G>A	c.(88-90)Gac>Aac	p.D30N	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	30						keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						CTGGCAGGTGGACGACTGCCC	0.682000													27	99					0	0	1	0	0
GADD45G	10912	broad.mit.edu	37	9	92220945	92220945	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:92220945A>C	ENST00000252506.6	+	4	540	c.431A>C	c.(430-432)gAg>gCg	p.E144A	GADD45G_ENST00000375769.1_Missense_Mutation_p.E126A|GADD45G_ENST00000494726.1_3'UTR	NM_006705.3	NP_006696.1	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	144					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding			lung(2)	2						TTTTGCGAGGAGAGCCGCAGC	0.682000													4	30					0	0	1	0	0
STAC2	342667	broad.mit.edu	37	17	37368614	37368614	+	Silent	SNP	G	G	A	rs147042988		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:37368614G>A	ENST00000333461.5	-	11	1536	c.1167C>T	c.(1165-1167)gaC>gaT	p.D389D		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	389					intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						GGATGAAGCCGTCAGCATCCT	0.637000													5	33					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100075586	100075586	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:100075586G>A	ENST00000375202.2	+	19	1902	c.550G>A	c.(550-552)Gct>Act	p.A184T	CCDC180_ENST00000411667.2_Missense_Mutation_p.A184T|CCDC180_ENST00000460482.2_3'UTR|CCDC180_ENST00000395220.1_Missense_Mutation_p.A323T|CCDC180_ENST00000357054.1_Missense_Mutation_p.A323T|CCDC180_ENST00000529487.1_Missense_Mutation_p.A184T|RP11-23J9.4_ENST00000534123.1_RNA					coiled-coil domain containing 180																		CTACGAGAGCGCTCTGGCCAG	0.542000													18	135					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70446282	70446282	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:70446282G>A	ENST00000373644.4	+	11	5431	c.5222G>A	c.(5221-5223)cGc>cAc	p.R1741H		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1741					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						GCACCCCGCCGCAAAAAAAGA	0.498000													4	120					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98354062	98354062	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:98354062G>A	ENST00000264972.5	+	11	1631	c.1416G>A	c.(1414-1416)cgG>cgA	p.R472R	ZAP70_ENST00000442208.1_Silent_p.R346R|ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000451498.2_Silent_p.R165R	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	472	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						TGGTTAACCGGCACTACGCCA	0.597000													3	68					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80101317	80101317	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:80101317C>T	ENST00000466387.1	+	10	1425	c.701C>T	c.(700-702)gCc>gTc	p.A234V	CTNNA2_ENST00000361291.4_Missense_Mutation_p.A268V|CTNNA2_ENST00000540488.1_Missense_Mutation_p.A234V|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A234V|CTNNA2_ENST00000541047.1_Missense_Mutation_p.A234V|CTNNA2_ENST00000402739.4_Missense_Mutation_p.A234V			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	234					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CCAGATGTCGCCGCTACGAGA	0.582000													38	78					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36631033	36631033	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:36631033C>T	ENST00000373448.2	-	5	2887	c.2649G>A	c.(2647-2649)ctG>ctA	p.L883L	TTI1_ENST00000373447.3_Silent_p.L883L|TTI1_ENST00000449821.1_Silent_p.L883L	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	883							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						CACTGACCTTCAGGCGGATTT	0.532000													29	116					0	0	1	0	0
MAS1L	116511	broad.mit.edu	37	6	29455445	29455445	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:29455445C>A	ENST00000377127.3	-	1	293	c.235G>T	c.(235-237)Gcc>Tcc	p.A79S		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	79						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						GCCTTGGGGGCAATGATATTC	0.512000													24	67					3.08376e-08	3.39473e-08	1	1	0
FAIM	55179	broad.mit.edu	37	3	138351800	138351800	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:138351800C>A	ENST00000338446.4	+	6	1204	c.521C>A	c.(520-522)aCt>aAt	p.T174N	FAIM_ENST00000393035.2_Missense_Mutation_p.T140N|FAIM_ENST00000393034.2_Missense_Mutation_p.T140N|FAIM_ENST00000464668.1_Missense_Mutation_p.T140N|FAIM_ENST00000360570.3_Missense_Mutation_p.T162N	NM_001033030.1	NP_001028202.1	Q9NVQ4	FAIM1_HUMAN	Fas apoptotic inhibitory molecule	140					apoptosis	cytoplasm				kidney(1)|upper_aerodigestive_tract(1)	2						GGGACTGAAACTCACTTCAGT	0.413000													68	123					1.93348e-29	2.30259e-29	1	1	0
KMT2B	9757	broad.mit.edu	37	19	36214909	36214909	+	Splice_Site	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:36214909G>T	ENST00000222270.7	+	8	3334		c.e8+1		KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Splice_Site	NM_014727.1	NP_055542.1																					CGAGAAAATGGTGCGAACTGC	0.552000													5	41					2.0095e-06	2.15774e-06	1	1	0
UNC80	285175	broad.mit.edu	37	2	210642247	210642247	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:210642247C>T	ENST00000439458.1	+	4	644	c.564C>T	c.(562-564)ttC>ttT	p.F188F	UNC80_ENST00000272845.5_Silent_p.F188F|UNC80_ENST00000478701.1_3'UTR	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	188						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						TGGAGCTCTTCGTGTTTCTGT	0.502000													71	124					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049362	42049362	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:42049362G>T	ENST00000372584.1	-	3	2121	c.1107C>A	c.(1105-1107)agC>agA	p.S369R	HIVEP3_ENST00000429157.2_Missense_Mutation_p.S369R|HIVEP3_ENST00000372583.1_Missense_Mutation_p.S369R|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S369R	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	369	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCTTCCTCTCGCTTAAGCGGA	0.557000													4	170					1	1	1	1	0
SSPO	23145	broad.mit.edu	37	7	149510810	149510810	+	RNA	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:149510810C>T	ENST00000378016.2	+	0	10095							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGGGTCACTGCAGCTGCCTGG	0.697000													13	39					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11996046	11996046	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:11996046G>A	ENST00000333796.3	-	1	540	c.224C>T	c.(223-225)cCt>cTt	p.P75L	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	75					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						CACCGCAGCAGGTCTCCTGCT	0.572000													15	346					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31671745	31671745	+	Silent	SNP	A	A	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:31671745A>G	ENST00000395934.2	+	9	1126	c.1119A>G	c.(1117-1119)ttA>ttG	p.L373L	Z83001.1_ENST00000429821.1_RNA|ELP4_ENST00000350638.5_Silent_p.L373L|ELP4_ENST00000379163.5_Silent_p.L374L			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	373					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					CTTTTAAATTAAAAAGGAAGC	0.269000													16	69					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111430849	111430849	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr4:111430849G>A	ENST00000265162.5	+	5	1422	c.1080G>A	c.(1078-1080)gaG>gaA	p.E360E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	360	Substrate binding (By similarity).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GTGCCATGGAGAACTGGGGAC	0.443000													25	132					0	0	1	0	0
CD55	1604	broad.mit.edu	37	1	207532966	207532966	+	Missense_Mutation	SNP	G	G	T	rs55963761		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:207532966G>T	ENST00000314754.8	+	11	1340	c.1275G>T	c.(1273-1275)gaG>gaT	p.E425D	CD55_ENST00000367067.4_3'UTR|CD55_ENST00000391920.4_3'UTR|CD55_ENST00000367065.5_Missense_Mutation_p.E424D|CD55_ENST00000367064.3_3'UTR|CD55_ENST00000465534.1_3'UTR|CD55_ENST00000367062.4_3'UTR|CD55_ENST00000391921.4_3'UTR	NM_001114752.1	NP_001108224.1	P08174	DAF_HUMAN	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	0					complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16					Chloramphenicol(DB00446)	CCAAAGAAGAGTTAAGAAGAA	0.353000													3	72					1	1	1	1	0
DLG4	1742	broad.mit.edu	37	17	7099547	7099547	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:7099547G>A	ENST00000399510.2	-	13	2274	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F	DLG4_ENST00000399506.2_Silent_p.F431F|DLG4_ENST00000302955.6_Silent_p.F428F	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	431	SH3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						ACCTGATGTAGAAACCCCTTT	0.642000													5	85					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088876	9088876	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:9088876G>A	ENST00000397910.4	-	1	3142	c.2939C>T	c.(2938-2940)tCa>tTa	p.S980L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	980	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S980L(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTTGTTGCTGAAGGTAACCC	0.458000													86	307					0	0	1	0	0
PLIN1	5346	broad.mit.edu	37	15	90213327	90213327	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:90213327G>A	ENST00000300055.5	-	5	647	c.482C>T	c.(481-483)gCg>gTg	p.A161V	PLIN1_ENST00000430628.2_Missense_Mutation_p.A161V	NM_002666.4	NP_002657.3	O60240	PLIN1_HUMAN	perilipin 1	161					triglyceride catabolic process	lipid particle	lipid binding	p.A161V(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(2)	13						AGCAAATTCCGCAGTGTCTCT	0.627000													9	37					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201012531	201012531	+	Silent	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:201012531G>T	ENST00000362061.3	-	40	5152	c.4926C>A	c.(4924-4926)gtC>gtA	p.V1642V	CACNA1S_ENST00000367338.3_Silent_p.V1623V	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1642					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTCCAAGAAGACAGGTGACT	0.542000											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	112					3.11337e-16	3.51597e-16	1	1	0
MAP2K1	5604	broad.mit.edu	37	15	66727455	66727455	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:66727455G>T	ENST00000307102.5	+	2	702	c.171G>T	c.(169-171)aaG>aaT	p.K57N		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	57					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.K57N(3)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						TTACCCAGAAGCAGAAGGTGG	0.542000													47	286					4.18559e-23	4.85232e-23	1	1	0
FHOD1	29109	broad.mit.edu	37	16	67272317	67272317	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67272317C>T	ENST00000258201.4	-	4	654	c.407G>A	c.(406-408)cGc>cAc	p.R136H	FHOD1_ENST00000567687.1_Intron	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	136	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GAGGGAGCGGCGGAGCTCAGG	0.542000													13	39					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40743859	40743859	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:40743859G>A	ENST00000373198.3	-	23	3380	c.3145C>T	c.(3145-3147)Cgc>Tgc	p.R1049C	PTPRT_ENST00000373193.3_Missense_Mutation_p.R1030C|PTPRT_ENST00000373184.1_Missense_Mutation_p.R1037C|PTPRT_ENST00000356100.2_Missense_Mutation_p.R1036C|PTPRT_ENST00000373190.1_Missense_Mutation_p.R1026C|PTPRT_ENST00000373187.1_Missense_Mutation_p.R1027C|PTPRT_ENST00000373201.1_Missense_Mutation_p.R1017C	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1027	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GTGAAGGTGCGTATGACGTAT	0.512000													31	133					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11903288	11903288	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:11903288C>G	ENST00000405977.1	+	5	1168	c.543C>G	c.(541-543)atC>atG	p.I181M	BTBD3_ENST00000378226.2_Missense_Mutation_p.I181M|BTBD3_ENST00000254977.3_Missense_Mutation_p.I120M|BTBD3_ENST00000488503.1_3'UTR|BTBD3_ENST00000399006.2_Missense_Mutation_p.I120M			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	181	BTB.									breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						ACAGATATATCTATTGTGATG	0.388000													27	132					0	0	1	0	0
GCC1	79571	broad.mit.edu	37	7	127222240	127222240	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:127222240T>C	ENST00000321407.2	-	2	2580	c.2156A>G	c.(2155-2157)aAt>aGt	p.N719S		NM_024523.5	NP_078799.2	Q96CN9	GCC1_HUMAN	GRIP and coiled-coil domain containing 1	719	GRIP.					Golgi membrane|plasma membrane	protein binding			breast(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GTACTCCAGATTGGCTCCCTC	0.567000													43	173					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	103					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51203960	51203960	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:51203960C>T	ENST00000395542.2	-	7	1111	c.927G>A	c.(925-927)tcG>tcA	p.S309S	COBL_ENST00000395540.2_Silent_p.S284S|COBL_ENST00000441453.1_Silent_p.S284S|COBL_ENST00000265136.7_Silent_p.S284S			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	284	Pro-rich.							p.S284S(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TGCTGCCCAGCGAGAGGGATG	0.577000													14	69					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123103082	123103082	+	Translation_Start_Site	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:123103082G>A	ENST00000436959.3	+	0	1753				KNTC1_ENST00000450485.2_Missense_Mutation_p.A972T|KNTC1_ENST00000333479.7_Missense_Mutation_p.A2047T|KNTC1_ENST00000537348.1_3'UTR			P50748	KNTC1_HUMAN	kinetochore associated 1						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GAGTCTCATCGCTGTCCTCGA	0.338000													19	57					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106054658	106054658	+	RNA	SNP	T	T	G	rs114771275	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:106054658T>G	ENST00000390539.2	-	0	74																											GGACCAGGCATGCGACGACCA	0.622000													4	83					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191224	152191224	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:152191224C>T	ENST00000368801.2	-	3	2956	c.2881G>A	c.(2881-2883)Ggc>Agc	p.G961S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	961					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTAGAGCCGTGTTGTTCG	0.537000													102	382					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57862003	57862003	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:57862003C>T	ENST00000228682.2	+	10	1395	c.1304C>T	c.(1303-1305)gCc>gTc	p.A435V	GLI1_ENST00000546141.1_Missense_Mutation_p.A394V|GLI1_ENST00000543426.1_Missense_Mutation_p.A307V	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	435					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			CCAGAGGGTGCCATGGTGAGA	0.582000													3	57					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100696279	100696279	+	Silent	SNP	G	G	A	rs146965923		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:100696279G>A	ENST00000306151.4	+	10	13180	c.13116G>A	c.(13114-13116)acG>acA	p.T4372T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4372						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCGTGACCACGGAAACTCACT	0.602000													19	102					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741347	140741347	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:140741347C>T	ENST00000522605.1	+	1	1645	c.1645C>T	c.(1645-1647)Cgc>Tgc	p.R549C	PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGAGCCTGCGCGTGTTAGT	0.697000													21	103					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852230	63852230	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:63852230C>T	ENST00000279873.7	+	10	3418	c.3008C>T	c.(3007-3009)cCg>cTg	p.P1003L	ARID5B_ENST00000309334.5_Missense_Mutation_p.P760L	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1003					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding	p.P1003Q(1)		NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					AAAATGAGCCCGCAGAACATT	0.552000													38	207					0	0	1	0	0
DAZL	1618	broad.mit.edu	37	3	16640104	16640104	+	Splice_Site	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:16640104G>T	ENST00000250863.8	-	2	352	c.63_splice	c.e2-1	p.S22_splice	DAZL_ENST00000399444.2_Splice_Site_p.S2_splice	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	2					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						ATTTGCAGTAGACTGTAATTT	0.353000													5	225					0.0215528	0.0225873	1	1	0
FBXL2	25827	broad.mit.edu	37	3	33425643	33425643	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:33425643G>T	ENST00000484457.1	+	14	1205	c.1114G>T	c.(1114-1116)Gag>Tag	p.E372*	FBXL2_ENST00000283627.6_3'UTR|FBXL2_ENST00000542085.1_Nonsense_Mutation_p.E82*|FBXL2_ENST00000538892.1_Nonsense_Mutation_p.E304*|FBXL2_ENST00000538181.1_Nonsense_Mutation_p.E288*|FBXL2_ENST00000446237.3_Nonsense_Mutation_p.E113*|FBXL2_ENST00000507198.1_Nonsense_Mutation_p.E304*	NM_012157.3	NP_036289.3	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	372					interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|urinary_tract(1)	15						GGAGCGCCTCGAGCTGTACGA	0.592000													3	118					1	1	1	1	0
KIAA1210	57481	broad.mit.edu	37	X	118217058	118217058	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chrX:118217058T>C	ENST00000402510.2	-	13	4873	c.4874A>G	c.(4873-4875)cAa>cGa	p.Q1625R		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1625										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CTTTTTAGGTTGGTTTTCATT	0.388000													34	61					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708596	126708596	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:126708596G>A	ENST00000393409.2	+	1	1160	c.1160G>A	c.(1159-1161)tGg>tAg	p.W387*	PLXNA1_ENST00000251772.4_Nonsense_Mutation_p.W364*	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	387	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		TCCCTGCCGTGGCTGCTCAAC	0.642000													32	91					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38939326	38939326	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:38939326G>A	ENST00000355481.4	+	11	1126	c.995G>A	c.(994-996)gGc>gAc	p.G332D	RYR1_ENST00000360985.3_Missense_Mutation_p.G332D|RYR1_ENST00000359596.3_Missense_Mutation_p.G332D	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	332					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GATGTGGAGGGCATGGGCCCC	0.637000													41	164					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97917661	97917661	+	RNA	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:97917661G>T	ENST00000534948.1	+	0	2439							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AGCAAGTTCAGAAAAAGAAAT	0.323000													36	223					4.65686e-17	5.30478e-17	1	1	0
GPLD1	2822	broad.mit.edu	37	6	24437400	24437400	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:24437400C>T	ENST00000230036.1	-	21	2248	c.2138G>A	c.(2137-2139)cGc>cAc	p.R713H		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	713						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						GGAGAAGCGGCGGTCTCCGCT	0.562000													22	116					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80620359	80620359	+	Silent	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:80620359T>C	ENST00000466387.1	+	12	1804	c.1080T>C	c.(1078-1080)gaT>gaC	p.D360D	CTNNA2_ENST00000361291.4_Silent_p.D394D|CTNNA2_ENST00000343114.3_Silent_p.D39D|CTNNA2_ENST00000540488.1_Silent_p.D360D|CTNNA2_ENST00000496558.1_Silent_p.D360D|CTNNA2_ENST00000541047.1_Silent_p.D360D|CTNNA2_ENST00000402739.4_Silent_p.D360D			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	360					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAAAAGGAGATCCTCTCAACA	0.284000													63	118					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37919970	37919970	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:37919970C>T	ENST00000377707.3	-	6	1943	c.1378G>A	c.(1378-1380)Gcc>Acc	p.A460T	RP11-613M10.9_ENST00000540557.1_Intron	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	460	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TTGGTTTTGGCCAGTTTCATG	0.502000													5	161					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69948722	69948722	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:69948722C>T	ENST00000358913.5	+	13	3252	c.2764C>T	c.(2764-2766)Cgt>Tgt	p.R922C	MYPN_ENST00000540630.1_Missense_Mutation_p.R922C|MYPN_ENST00000354393.2_Missense_Mutation_p.R647C	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	922						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TCGCTTGGAACGTACTCCTGT	0.413000													15	63					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156456763	156456763	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:156456763C>T	ENST00000339252.3	-	8	1608	c.1076G>A	c.(1075-1077)aGt>aAt	p.S359N	HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000544197.1_Missense_Mutation_p.S359N|HAVCR1_ENST00000523175.1_Missense_Mutation_p.S359N|HAVCR1_ENST00000425854.1_Missense_Mutation_p.V348I|HAVCR1_ENST00000522693.1_Missense_Mutation_p.V348I	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	354					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGCATAAAGACTATTCTCAAT	0.408000													15	61					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91142993	91142993	+	Silent	SNP	G	G	A	rs149388931		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:91142993G>A	ENST00000357056.2	-	9	1147	c.1026C>T	c.(1024-1026)gaC>gaT	p.D342D	TTC7B_ENST00000328459.6_Silent_p.D342D			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	342							binding	p.D342D(1)		NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				TCAGCACAGCGTCCCGGTTGG	0.532000													17	98					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99554563	99554563	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr13:99554563G>A	ENST00000376460.1	-	12	1439	c.1359C>T	c.(1357-1359)gcC>gcT	p.A453A	DOCK9_ENST00000339416.2_Silent_p.A454A|DOCK9_ENST00000448493.2_Silent_p.A465A|DOCK9_ENST00000442173.1_Silent_p.A453A	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	454					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTGCATGGCGGCTTCATGAA	0.532000													15	49					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528080	157528080	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:157528080G>A	ENST00000346085.5	+	20	5806	c.5805G>A	c.(5803-5805)gcG>gcA	p.A1935A	ARID1B_ENST00000350026.5_Silent_p.A1922A|ARID1B_ENST00000367148.1_Silent_p.A1975A|ARID1B_ENST00000275248.4_Silent_p.A1917A	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1922					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTACCATCGCGCACTGGCAGG	0.537000													37	147					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107330644	107330644	+	Missense_Mutation	SNP	C	C	T	rs147952620	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:107330644C>T	ENST00000265715.3	+	10	1449	c.1225C>T	c.(1225-1227)Cgc>Tgc	p.R409C		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	409			R -> H (in PDS).|R -> P (in DFNB4).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						TGCTCTTTCCCGCACGGCCGT	0.493000									Pendred syndrome				42	145					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516473	102516473	+	RNA	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:102516473G>A	ENST00000557932.1	+	0	1421																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						ATCCTAGGGGGCTCCATGACA	0.642000													4	63					0	0	1	0	0
NCBP1	4686	broad.mit.edu	37	9	100424349	100424349	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:100424349G>A	ENST00000375147.3	+	17	1882	c.1626G>A	c.(1624-1626)ttG>ttA	p.L542L		NM_002486.4	NP_002477.1	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	542					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)	19		Acute lymphoblastic leukemia(62;0.158)				TTAACCCATTGAAAATAGAAG	0.373000													12	96					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184101432	184101432	+	Splice_Site	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:184101432T>C	ENST00000204604.1	+	12	1686		c.e12+2		CHRD_ENST00000450923.1_Splice_Site|CHRD_ENST00000545352.1_Splice_Site|CHRD_ENST00000348986.3_Intron|EIF2B5_ENST00000444495.1_Intron	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin						BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGACACACGGTGAGGGCTCCA	0.607000													10	87					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108292090	108292090	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:108292090G>T	ENST00000370056.4	-	14	1660	c.1386C>A	c.(1384-1386)aaC>aaA	p.N462K	VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000527011.1_Missense_Mutation_p.N462K|VAV3_ENST00000371846.4_Missense_Mutation_p.N397K	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	462	PH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TCACCTTTTTGTTTTCTTTAT	0.289000													3	76					1	1	1	1	0
SESTD1	91404	broad.mit.edu	37	2	179979882	179979882	+	Silent	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:179979882C>A	ENST00000428443.3	-	16	2065	c.1749G>T	c.(1747-1749)ctG>ctT	p.L583L		NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	583					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATACTCTGTTCAGTCGAGGAA	0.433000													21	66					4.96729e-08	5.42262e-08	1	1	0
ITGAL	3683	broad.mit.edu	37	16	30510407	30510407	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:30510407G>A	ENST00000356798.6	+	16	2025	c.1845G>A	c.(1843-1845)gtG>gtA	p.V615V	ITGAL_ENST00000358164.5_Silent_p.V532V|ITGAL_ENST00000433423.2_Intron|RP11-297C4.1_ENST00000563751.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	615					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CCCGGCCCGTGGTGGATATGG	0.567000													11	49					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46903411	46903411	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:46903411G>A	ENST00000378623.1	-	20	2898	c.2656C>T	c.(2656-2658)Cga>Tga	p.R886*		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	886					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		ATGCCAGCTCGTTCAATCTTG	0.507000													25	85					0	0	1	0	0
SCFD1	23256	broad.mit.edu	37	14	31099754	31099754	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:31099754G>A	ENST00000458591.2	+	3	431	c.204G>A	c.(202-204)atG>atA	p.M68I	SCFD1_ENST00000396629.2_Intron|SCFD1_ENST00000544052.2_Start_Codon_SNP_p.M1I|SCFD1_ENST00000421551.3_Intron|SCFD1_ENST00000541123.1_5'UTR	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	68					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TAAGAGACATGGGAATCACTC	0.318000													29	140					0	0	1	0	0
CLDN17	26285	broad.mit.edu	37	21	31538657	31538657	+	Silent	SNP	G	G	A	rs138854149		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr21:31538657G>A	ENST00000286808.3	-	1	314	c.279C>T	c.(277-279)atC>atT	p.I93I		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	93					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						TAAGCAGGGCGATCAAGGAGA	0.557000													32	105					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903213	6903213	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:6903213G>A	ENST00000486284.1	+	1	412	c.138G>A	c.(136-138)gaG>gaA	p.E46E	GRM7_ENST00000389336.4_Silent_p.E46E|GRM7_ENST00000403881.1_Silent_p.E46E|GRM7_ENST00000402647.2_Silent_p.E46E|GRM7_ENST00000357716.4_Silent_p.E46E	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	46					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TCCGGATCGAGGGGGACGTCA	0.692000													3	12					0	0	1	0	0
ZNF610	162963	broad.mit.edu	37	19	52856994	52856994	+	Silent	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:52856994G>C	ENST00000601151.1	+	4	575	c.123G>C	c.(121-123)ctG>ctC	p.L41L	ZNF610_ENST00000327920.8_Silent_p.L41L|ZNF610_ENST00000321287.8_Silent_p.L41L|ZNF610_ENST00000403906.3_Silent_p.L41L	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGAAATCCCTGGACCCTGGAC	0.493000													32	140					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105858997	105858997	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:105858997C>T	ENST00000258456.1	+	1	798	c.682C>T	c.(682-684)Cgc>Tgc	p.R228C		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	228						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						GAACGCCGTGCGCGTGCACAA	0.652000													5	150					0	0	1	0	0
FAM101A	144347	broad.mit.edu	37	12	124798975	124798975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:124798975C>A	ENST00000389727.3	+	3	555	c.555C>A	c.(553-555)tgC>tgA	p.C185*	FAM101A_ENST00000338359.4_Nonsense_Mutation_p.C104*|FAM101A_ENST00000324038.3_Nonsense_Mutation_p.C104*|FAM101A_ENST00000546355.1_Nonsense_Mutation_p.C104*			Q6ZTI6	F101A_HUMAN	family with sequence similarity 101, member A	185										endometrium(1)|kidney(1)|lung(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CCCTGCACTGCAGCCTGGGCC	0.706000													11	45					0.000673444	0.000717245	1	1	0
VPS13C	54832	broad.mit.edu	37	15	62299547	62299547	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:62299547G>A	ENST00000261517.5	-	15	1323	c.1250C>T	c.(1249-1251)aCa>aTa	p.T417I	VPS13C_ENST00000395896.4_Missense_Mutation_p.T417I|VPS13C_ENST00000249837.3_Missense_Mutation_p.T374I|VPS13C_ENST00000395898.3_Missense_Mutation_p.T374I	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	417					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TTTAGACTGTGTTAACTTGTT	0.313000													11	73					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130921701	130921701	+	Missense_Mutation	SNP	C	C	T	rs139344487	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:130921701C>T	ENST00000261655.4	-	10	1904	c.1741G>A	c.(1741-1743)Gtt>Att	p.V581I	RIMBP2_ENST00000535703.1_Missense_Mutation_p.V489I|RIMBP2_ENST00000536002.1_Missense_Mutation_p.V489I	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	581						cell junction|synapse		p.V581I(1)		NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGGGGGGAACGGCAGCAACT	0.662000													7	8					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7670058	7670058	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:7670058A>T	ENST00000299492.4	+	19	2213	c.1825A>T	c.(1825-1827)Agg>Tgg	p.R609W	PPFIBP2_ENST00000528883.1_Missense_Mutation_p.R497W|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000530181.1_Missense_Mutation_p.R466W|PPFIBP2_ENST00000533792.1_Missense_Mutation_p.R451W	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	609	SAM 1.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCCACTCCACAGGAAGAAGCT	0.448000													57	233					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106552717	106552717	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:106552717C>T	ENST00000369096.4	+	5	916	c.682C>T	c.(682-684)Cta>Tta	p.L228L	PRDM1_ENST00000369091.2_Silent_p.L192L|PRDM1_ENST00000369089.3_Silent_p.L94L	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	228					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACAGAGCAGTCTAAAGCAACC	0.448000			"""D, N, Mis, F, S"""		DLBCL								70	332					0	0	1	0	0
RCBTB2	1102	broad.mit.edu	37	13	49076887	49076887	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr13:49076887C>T	ENST00000344532.3	-	11	1513	c.1090G>A	c.(1090-1092)Gcc>Acc	p.A364T	RCBTB2_ENST00000544492.1_Missense_Mutation_p.A90T|RCBTB2_ENST00000430805.2_Missense_Mutation_p.A369T|RCBTB2_ENST00000544904.1_3'UTR	NM_001268.2	NP_001259.1	O95199	RCBT2_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	364							Ran guanyl-nucleotide exchange factor activity	p.A364S(2)		breast(5)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(3)	31		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CACGTGACGGCGGGCGTGGCA	0.592000													27	119					0	0	1	0	0
KDELC2	143888	broad.mit.edu	37	11	108350193	108350193	+	Silent	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:108350193G>T	ENST00000434945.2	-	5	1262	c.960C>A	c.(958-960)acC>acA	p.T320T	KDELC2_ENST00000375648.1_Silent_p.T320T|KDELC2_ENST00000532730.1_Intron|KDELC2_ENST00000323468.5_Silent_p.T376T			Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2	376						endoplasmic reticulum lumen		p.T376T(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		AAGCAGCCACGGTCCCATCCA	0.408000													13	72					2.39187e-15	2.67808e-15	1	1	0
CSNK1A1P1	161635	broad.mit.edu	37	15	37109441	37109441	+	RNA	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:37109441C>A	ENST00000430593.3	-	0	781					NR_027320.1																						CTGCTTTCTGCTTTAACTTTG	0.473000													15	69					1.99824e-07	2.16338e-07	1	1	0
TNFRSF25	8718	broad.mit.edu	37	1	6521694	6521694	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:6521694G>A	ENST00000377782.3	-	10	1148	c.1081C>T	c.(1081-1083)Cgc>Tgc	p.R361C	TNFRSF25_ENST00000348333.3_Missense_Mutation_p.R307C|TNFRSF25_ENST00000351748.3_Missense_Mutation_p.R169C|TNFRSF25_ENST00000356876.3_Missense_Mutation_p.R352C|TNFRSF25_ENST00000351959.5_Missense_Mutation_p.R315C	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	352	Death.				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCCAGCGTGCGCACGAACTCC	0.687000													8	35					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142098954	142098954	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:142098954G>A	ENST00000264951.4	-	23	2802	c.2685C>T	c.(2683-2685)ccC>ccT	p.P895P	XRN1_ENST00000392981.2_Silent_p.P895P	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	895					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						CATCAAGATTGGGTTCACATG	0.328000													19	79					0	0	1	0	0
CRYZ	1429	broad.mit.edu	37	1	75172795	75172795	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:75172795G>A	ENST00000417775.1	-	8	1228	c.724C>T	c.(724-726)Cga>Tga	p.R242*	CRYZ_ENST00000340866.5_Nonsense_Mutation_p.R242*|CRYZ_ENST00000370872.3_Nonsense_Mutation_p.R105*|CRYZ_ENST00000370871.3_Intron|CRYZ_ENST00000492102.1_5'UTR	NM_001130042.1	NP_001123514.1	Q08257	QOR_HUMAN	crystallin, zeta (quinone reductase)	242					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)	10					Dicumarol(DB00266)	ACTATCACTCGTCCTCCATGT	0.274000													34	145					0	0	1	0	0
RASGRP1	10125	broad.mit.edu	37	15	38808519	38808519	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:38808519T>C	ENST00000310803.5	-	6	731	c.554A>G	c.(553-555)cAa>cGa	p.Q185R	RASGRP1_ENST00000561180.1_Missense_Mutation_p.Q236R|RASGRP1_ENST00000558164.1_Missense_Mutation_p.Q185R|RASGRP1_ENST00000450598.2_Missense_Mutation_p.Q185R|RASGRP1_ENST00000539159.1_Missense_Mutation_p.Q137R|RASGRP1_ENST00000559830.1_Missense_Mutation_p.Q185R	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	185					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTTTATCCTTTGAGTAAGTTT	0.443000													19	111					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578503	7578503	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:7578503C>T	ENST00000420246.2	-	5	559	c.427G>A	c.(427-429)Gtg>Atg	p.V143M	TP53_ENST00000359597.4_Missense_Mutation_p.V143M|TP53_ENST00000413465.2_Missense_Mutation_p.V143M|TP53_ENST00000455263.2_Missense_Mutation_p.V143M|TP53_ENST00000269305.4_Missense_Mutation_p.V143M|TP53_ENST00000445888.2_Missense_Mutation_p.V143M	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	143	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143M(19)|p.0?(8)|p.V143L(4)|p.V143fs*27(2)|p.V11M(1)|p.L137_W146del10(1)|p.V143fs*29(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V50M(1)|p.V143_S149del(1)|p.C141fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACAGCTGCACAGGGCAGGTC	0.587000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	47					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56489977	56489977	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:56489977G>T	ENST00000370754.5	-	34	4708	c.4709C>A	c.(4708-4710)tCa>tAa	p.S1570*	DST_ENST00000312431.6_Nonsense_Mutation_p.S1392*|DST_ENST00000370765.6_Nonsense_Mutation_p.S1066*|DST_ENST00000421834.2_Nonsense_Mutation_p.S1392*|DST_ENST00000370769.4_Nonsense_Mutation_p.S1392*|DST_ENST00000244364.6_Nonsense_Mutation_p.S1066*|DST_ENST00000370788.2_Nonsense_Mutation_p.S1392*|DST_ENST00000361203.3_Nonsense_Mutation_p.S1392*|DST_ENST00000446842.2_Nonsense_Mutation_p.S1066*|DST_ENST00000518935.1_Nonsense_Mutation_p.S1066*			Q03001	DYST_HUMAN	dystonin	1392					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAGATCTGCTGAACTCTGCAT	0.363000													63	273					4.60343e-24	5.38437e-24	1	1	0
OR10T2	128360	broad.mit.edu	37	1	158368907	158368907	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:158368907G>A	ENST00000334438.1	-	1	349	c.350C>T	c.(349-351)gCt>gTt	p.A117V		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TCCCATCACAGCAATGAGGAG	0.493000													4	155					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358822	102358822	+	Silent	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:102358822T>C	ENST00000332238.4	+	1	457	c.433T>C	c.(433-435)Tta>Cta	p.L145L		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TCTATACTTTTTAGCCACTTC	0.408000													36	241					0	0	1	0	0
RPL26L1	51121	broad.mit.edu	37	5	172386987	172386987	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:172386987G>C	ENST00000521476.1	+	2	235	c.111G>C	c.(109-111)gaG>gaC	p.E37D	RPL26L1_ENST00000519974.1_Missense_Mutation_p.E37D|RPL26L1_ENST00000265100.2_Missense_Mutation_p.E37D|RPL26L1_ENST00000519239.1_Missense_Mutation_p.E37D			Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	37					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|lung(2)|prostate(1)|urinary_tract(1)	7	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTCCAAGGAGCTGCGGCAGA	0.602000													37	180					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132522	11132522	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:11132522C>T	ENST00000358026.2	+	19	3022	c.2738C>T	c.(2737-2739)cCg>cTg	p.P913L	SMARCA4_ENST00000444061.3_Missense_Mutation_p.P913L|SMARCA4_ENST00000413806.3_Missense_Mutation_p.P913L|SMARCA4_ENST00000589677.1_Missense_Mutation_p.P913L|SMARCA4_ENST00000429416.3_Missense_Mutation_p.P913L|SMARCA4_ENST00000344626.4_Missense_Mutation_p.P913L|SMARCA4_ENST00000541122.2_Missense_Mutation_p.P913L|SMARCA4_ENST00000590574.1_Missense_Mutation_p.P913L|SMARCA4_ENST00000450717.3_Missense_Mutation_p.P913L	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	913	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.P913Q(2)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACGGGCACACCGCTGCAGAAC	0.612000			"""F, N, Mis"""		NSCLC								8	44					0	0	1	0	0
C10orf111	221060	broad.mit.edu	37	10	15138710	15138710	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:15138710C>T	ENST00000378207.3	-	2	387	c.114G>A	c.(112-114)aaG>aaA	p.K38K		NM_153244.1	NP_694976.1	Q8N326	CJ111_HUMAN	chromosome 10 open reading frame 111	38						integral to membrane				lung(5)|upper_aerodigestive_tract(1)	6						CTGCCTTTCTCTTTTCGGGCT	0.498000													36	268					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161524781	161524781	+	Silent	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:161524781C>T	ENST00000356592.3	+	4	925	c.465C>T	c.(463-465)tcC>tcT	p.S155S	GABRG2_ENST00000393933.4_Silent_p.S60S|GABRG2_ENST00000361925.4_Silent_p.S155S|GABRG2_ENST00000414552.2_Silent_p.S155S	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	155					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TCAGAAATTCCAAAAAAGCTG	0.428000													38	165					0	0	1	0	0
MYCL	4610	broad.mit.edu	37	1	40366778	40366778	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:40366778C>T	ENST00000397332.2	-	2	543	c.419G>A	c.(418-420)aGc>aAc	p.S140N	MYCL_ENST00000372816.2_Missense_Mutation_p.S110N|MYCL_ENST00000372815.1_Missense_Mutation_p.S140N|MYCL_ENST00000429311.1_Missense_Mutation_p.S110N	NM_001033081.2|NM_001033082.2	NP_001028253.1|NP_001028254.2			v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog																		GAGCCGGTCGCTCACAGCTCT	0.726000													3	16					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144810795	144810795	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:144810795G>A	ENST00000388913.3	-	5	961	c.836C>T	c.(835-837)gCg>gTg	p.A279V		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	279					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCGGACTGCGCGAAGAGGAT	0.672000													4	44					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141116420	141116420	+	Missense_Mutation	SNP	C	C	T	rs150879175	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:141116420C>T	ENST00000389484.3	-	73	12198	c.11227G>A	c.(11227-11229)Ggt>Agt	p.G3743S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3743	LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G3743S(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAATTGTCACCGCATTCATCA	0.398000										TSP Lung(27;0.18)			43	212					0	0	1	0	0
ZCCHC24	219654	broad.mit.edu	37	10	81154151	81154151	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:81154151G>A	ENST00000372336.3	-	3	679	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	ZCCHC24_ENST00000372333.3_Missense_Mutation_p.A105V|RP11-342M3.5_ENST00000438554.2_RNA	NM_153367.3	NP_699198.2	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	165							nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)	9						CCGAAGCAGCGCTTTTTGCCC	0.567000													42	174					0	0	1	0	0
ENKD1	84080	broad.mit.edu	37	16	67700071	67700071	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67700071G>A	ENST00000243878.4	-	2	504	c.183C>T	c.(181-183)ccC>ccT	p.P61P	ENKD1_ENST00000602644.1_Silent_p.P61P	NM_032140.1	NP_115516.1			enkurin domain containing 1																		CTCCGGCACCGGGACCGATGC	0.682000													30	110					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54327166	54327166	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:54327166C>G	ENST00000324134.6	-	1	431	c.263G>C	c.(262-264)aGa>aCa	p.R88T	NLRP12_ENST00000351894.4_Missense_Mutation_p.R88T|NLRP12_ENST00000391772.1_Missense_Mutation_p.R88T|NLRP12_ENST00000535162.1_Missense_Mutation_p.R88T|NLRP12_ENST00000354278.3_Missense_Mutation_p.R88T|NLRP12_ENST00000345770.5_Missense_Mutation_p.R88T|NLRP12_ENST00000391773.1_Missense_Mutation_p.R88T|NLRP12_ENST00000391775.3_Missense_Mutation_p.R88T	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	88	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCTCTGTCCTCTCTCCCACAG	0.587000													65	224					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48149471	48149471	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:48149471C>T	ENST00000311303.3	-	13	2189	c.1844G>A	c.(1843-1845)cGc>cAc	p.R615H	ABCC12_ENST00000448542.1_Missense_Mutation_p.R615H|ABCC12_ENST00000416054.1_Missense_Mutation_p.A591T	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	615	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.R615H(1)		NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GTAGACAGCGCGGGCCAGGCT	0.632000													21	61					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	171					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35467758	35467758	+	Splice_Site	SNP	G	G	A	rs138772407	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:35467758G>A	ENST00000229771.6	-	14	1574	c.1495_splice	c.e14+1	p.P499_splice	TULP1_ENST00000322263.4_Splice_Site_p.P446_splice	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	499					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						AGGTACTCACGGTCATCAGCG	0.587000													71	107					0	0	1	0	0
REXO4	57109	broad.mit.edu	37	9	136279920	136279920	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:136279920C>A	ENST00000371942.3	-	2	636	c.437G>T	c.(436-438)cGc>cTc	p.R146L	REXO4_ENST00000478037.1_5'UTR|ADAMTS13_ENST00000485925.1_Intron|REXO4_ENST00000371935.2_Missense_Mutation_p.A87S	NM_020385.2	NP_065118.2	Q9GZR2	REXO4_HUMAN	REX4, RNA exonuclease 4 homolog (S. cerevisiae)	146						nucleolus	exonuclease activity|nucleic acid binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	15				OV - Ovarian serous cystadenocarcinoma(145;8.58e-08)|Epithelial(140;9.55e-07)|all cancers(34;1.05e-05)		GGCCTTGGTGCGAGGTACTGG	0.542000													4	181					1	1	1	1	0
MARCH7	64844	broad.mit.edu	37	2	160585576	160585576	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:160585576C>T	ENST00000259050.3	+	2	165	c.43C>T	c.(43-45)Caa>Taa	p.Q15*	MARCH7_ENST00000409175.1_Nonsense_Mutation_p.Q15*|MARCH7_ENST00000473749.1_3'UTR|MARCH7_ENST00000539065.1_Nonsense_Mutation_p.Q15*	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	15	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						AATTTCTGTTCAACCTTCCAG	0.343000													34	70					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78899184	78899184	+	Silent	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:78899184G>A	ENST00000306801.3	+	24	3185	c.2823G>A	c.(2821-2823)gcG>gcA	p.A941A	RPTOR_ENST00000544334.2_Silent_p.A783A|RPTOR_ENST00000575542.1_3'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	941					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						CGGACGACGCGGACGATGCTG	0.572000													14	65					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57968982	57968982	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:57968982T>C	ENST00000455537.2	+	16	2106	c.1832T>C	c.(1831-1833)cTc>cCc	p.L611P	KIF5A_ENST00000286452.5_Missense_Mutation_p.L522P	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	611					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CTGGAGAACCTCCAGGTGGAG	0.562000													10	40					0	0	1	0	0
RAB2B	84932	broad.mit.edu	37	14	21936559	21936559	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:21936559G>A	ENST00000397762.1	-	5	419	c.319C>T	c.(319-321)Cac>Tac	p.H107Y	RAB2B_ENST00000461909.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	107					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		GAACTAGAGTGCTGCCGGGCA	0.423000													10	49					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45367599	45367599	+	Missense_Mutation	SNP	G	G	T	rs150029332	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:45367599G>T	ENST00000559488.1	+	8	1100	c.1084G>T	c.(1084-1086)Gat>Tat	p.D362Y	ITGB3_ENST00000560629.1_Missense_Mutation_p.G350V|ITGB3_ENST00000571680.1_Missense_Mutation_p.D362Y|ITGB3_ENST00000435993.2_Missense_Mutation_p.D315Y	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	362	VWFA.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	TCTGTCCATGGATTCCAGCAA	0.493000													49	205					1.11015e-26	1.31018e-26	1	1	0
PXDN	7837	broad.mit.edu	37	2	1667514	1667514	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:1667514C>T	ENST00000252804.4	-	12	1480	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	477	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CAGGTGCCGCCGGTCCACGGA	0.602000													5	139					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119084258	119084258	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:119084258C>T	ENST00000264245.4	+	2	728	c.196C>T	c.(196-198)Cgg>Tgg	p.R66W		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	66	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						AAACATACAACGGCTAAGGTA	0.438000													17	100					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190423836	190423836	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:190423836T>G	ENST00000367462.3	-	2	416	c.185A>C	c.(184-186)gAt>gCt	p.D62A	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.I24L	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		62						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GTCCACAAAATCTGTGTATTC	0.468000													18	64					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9204522	9204522	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr18:9204522C>G	ENST00000262126.3	+	4	524	c.284C>G	c.(283-285)tCt>tGt	p.S95C	ANKRD12_ENST00000383440.2_Intron|ANKRD12_ENST00000400020.3_Intron|ANKRD12_ENST00000540578.2_3'UTR	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	95						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AGACTTATATCTTCTTACAGG	0.373000													41	126					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40474419	40474419	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:40474419T>A	ENST00000264657.5	-	21	2294	c.1982A>T	c.(1981-1983)gAt>gTt	p.D661V	STAT3_ENST00000585517.1_Missense_Mutation_p.D661V|STAT3_ENST00000389272.3_Missense_Mutation_p.D563V|STAT3_ENST00000404395.3_Missense_Mutation_p.D661V|STAT3_ENST00000588969.1_Missense_Mutation_p.D661V	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	661	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		ATTGGTAGCATCCATGATCTT	0.483000									Hyperimmunoglobulin E Recurrent Infection Syndrome				59	230					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12259436	12259436	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:12259436C>T	ENST00000281141.4	+	6	690	c.410C>T	c.(409-411)tCc>tTc	p.S137F	CDC123_ENST00000455773.3_3'UTR|CDC123_ENST00000378900.2_Missense_Mutation_p.S137F	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	137					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						TTCAAGAGTTCCGATTTCATC	0.368000													14	141					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48913362	48913362	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:48913362C>G	ENST00000311378.4	+	1	592	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V	WFIKKN2_ENST00000426127.1_Intron	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	22						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			gctgctgctgctgctgctact	0.677000													2	13					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32620826	32620826	+	Silent	SNP	T	T	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:32620826T>A	ENST00000521670.1	+	12	1467	c.1359T>A	c.(1357-1359)tcT>tcA	p.S453S	NRG1_ENST00000287845.5_Intron|NRG1_ENST00000539990.1_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000341377.5_Intron|NRG1_ENST00000519301.1_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000287840.5_Intron			Q02297	NRG1_HUMAN	neuregulin 1	0					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TTAGATCTTCTTCCATTCCCC	0.418000													40	220					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104955091	104955091	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:104955091C>A	ENST00000507740.1	+	11	2250	c.2014C>A	c.(2014-2016)Cac>Aac	p.H672N	RIMS2_ENST00000406091.3_Missense_Mutation_p.H880N|RIMS2_ENST00000262231.10_Missense_Mutation_p.H719N|RIMS2_ENST00000436393.2_Missense_Mutation_p.H658N	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	942	PDZ.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GCCACTTCCCCACCCTTCTCC	0.388000										HNSCC(12;0.0054)			22	130					5.45024e-15	6.05069e-15	1	1	0
RNF44	22838	broad.mit.edu	37	5	175958006	175958006	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:175958006G>C	ENST00000274811.4	-	5	1006	c.482C>G	c.(481-483)aCc>aGc	p.T161S	RNF44_ENST00000537487.1_Missense_Mutation_p.T80S	NM_014901.4	NP_055716.1	Q7L0R7	RNF44_HUMAN	ring finger protein 44	161	Pro-rich.						zinc ion binding			endometrium(2)|lung(3)|prostate(1)|skin(1)|stomach(1)	8	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCTGCATGGTGCACGCCTG	0.667000													7	20					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187690	152187690	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:152187690T>A	ENST00000368801.2	-	3	6490	c.6415A>T	c.(6415-6417)Aga>Tga	p.R2139*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2139					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGATCTAGAGCCGTGT	0.572000													36	1435					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182767033	182767033	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:182767033A>G	ENST00000431877.2	+	8	1432	c.1253A>G	c.(1252-1254)gAt>gGt	p.D418G	SSFA2_ENST00000428267.2_Missense_Mutation_p.D265G|SSFA2_ENST00000409001.1_Missense_Mutation_p.D418G|SSFA2_ENST00000320370.7_Missense_Mutation_p.D418G	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	418						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCCAAATTAGATAGTGATTTC	0.383000													15	84					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062951	194062951	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:194062951G>C	ENST00000323830.3	-	2	570	c.481C>G	c.(481-483)Ccc>Gcc	p.P161A	CPN2_ENST00000429275.1_Missense_Mutation_p.P161A	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	161					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AGCCTCCTGGGCAGGGCCTGG	0.637000													11	93					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29990752	29990752	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:29990752T>G	ENST00000308893.4	+	8	1621	c.578T>G	c.(577-579)gTg>gGg	p.V193G	TAOK2_ENST00000279394.3_Missense_Mutation_p.V193G|TAOK2_ENST00000543033.1_Missense_Mutation_p.V193G	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	193	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GCACCCGAGGTGATCCTGGCC	0.582000													5	37					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202149679	202149688	+	Frame_Shift_Del	DEL	CTCTCCCATG	CTCTCCCATG	-			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:202149679_202149688delCTCTCCCATG	ENST00000358485.4	+	8	1316_1325	c.1120_1129delCTCTCCCATG	c.(1120-1131)gafs	p.LSHG374fs	CASP8_ENST00000264275.5_Frame_Shift_Del_p.LSHG332fs|CASP8_ENST00000432109.2_Frame_Shift_Del_p.LSHG315fs|CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000323492.7_Frame_Shift_Del_p.LSHG300fs|CASP8_ENST00000264274.9_Frame_Shift_Del_p.LSHG231fs	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	315					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						CTGCTGTATCCTCTCCCATGGAGACAAGGG	0.486										HNSCC(4;0.00038)			50	193	---	---	---	---					
NPPC	4880	broad.mit.edu	37	2	232790411	232790412	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:232790411_232790412insG	ENST00000409852.1	-	2	257_258	c.104_105insC	c.(103-105)cccfs	p.P35fs	NPPC_ENST00000295440.2_Frame_Shift_Ins_p.P35fs	NM_024409.2	NP_077720.1	P23582	ANFC_HUMAN	natriuretic peptide C	35					cGMP biosynthetic process|growth plate cartilage chondrocyte differentiation|growth plate cartilage chondrocyte proliferation|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vasoconstriction		hormone activity						all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;9.35e-14)|BRCA - Breast invasive adenocarcinoma(100;0.00119)|LUSC - Lung squamous cell carcinoma(224;0.00746)|Lung(119;0.00834)		CCTCTGCCGGCGGGGTTCGCGG	0.743													7	8	---	---	---	---					
FLT4	2324	broad.mit.edu	37	5	180040031	180040032	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:180040031_180040032insG	ENST00000261937.6	-	25	3488_3489	c.3410_3411insC	c.(3409-3411)cgafs	p.R1137fs	FLT4_ENST00000393347.3_Frame_Shift_Ins_p.R1137fs|FLT4_ENST00000502649.1_Frame_Shift_Ins_p.R1137fs	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1137	Protein kinase.		P -> S (in juvenile hemangioma).		positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCCAGCTCCGGGGCCCTCAT	0.653													31	188	---	---	---	---					
GS1-124K5.2	0	broad.mit.edu	37	7	65914885	65914886	+	RNA	DEL	AG	AG	-			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:65914885_65914886delAG	ENST00000442578.1	-	0	521																											TTTCAACTAAAGAGAGTATTGG	0.337													4	3	---	---	---	---					
JHDM1D-AS1	100134229	broad.mit.edu	37	7	139878082	139878089	+	RNA	DEL	TCCCTCCC	TCCCTCCC	-	rs57191915		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:139878082_139878089delTCCCTCCC	ENST00000566699.1	+	0	1022_1029					NR_024451.1																						cttccttccttccctccctccCTTTCCT	0.471													3	4	---	---	---	---					
CSMD3	114788	broad.mit.edu	37	8	113662425	113662425	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:113662425delT	ENST00000297405.5	-	19	3402	c.3158delA	c.(3157-3159)acfs	p.N1053fs	CSMD3_ENST00000343508.3_Frame_Shift_Del_p.N1013fs|CSMD3_ENST00000455883.2_Frame_Shift_Del_p.N949fs|CSMD3_ENST00000352409.3_Frame_Shift_Del_p.N1053fs	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1053	Sushi 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCACCAGTGGTTTTTTTCGCA	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	318	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651191	1651199	+	In_Frame_Del	DEL	GGCTGTGGA	GGCTGTGGA	-	rs71025763		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:1651191_1651199delGGCTGTGGA	ENST00000399676.2	+	1	159_167	c.121_129delGGCTGTGGA	c.(121-129)del	p.GCG47del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	47						keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ctgtggctccggctgtggaggctgtgggg	0.713													10	65	---	---	---	---					
TRAV14DV4	28669	broad.mit.edu	37	14	22392285	22392285	+	RNA	DEL	T	T	-			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:22392285delT	ENST00000390440.2	+	0	47																											AAGAAGAAGATTTTTTTTTAT	0.473													11	45	---	---	---	---					
CTCF	10664	broad.mit.edu	37	16	67645241	67645242	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67645241_67645242insG	ENST00000264010.4	+	3	950_951	c.506_507insG	c.(505-507)gggfs	p.G169fs	CTCF_ENST00000401394.1_Intron	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	169					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GTGGTTAAAGTGGGGGCCAATG	0.505													19	122	---	---	---	---					
CRYBB2P1	1416	broad.mit.edu	37	22	25855683	25855684	+	RNA	DEL	GT	GT	-	rs61433517		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr22:25855683_25855684delGT	ENST00000354451.2	+	0	366																											CTGGCAGCTGgtgtgtgtgtgt	0.525													2	4	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			3	6	---	---	---	---