Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ABCA13	154664	broad.mit.edu	37	7	48315902	48315902	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr7:48315902C>G	ENST00000435803.1	+	17	6663	c.6639C>G	c.(6637-6639)atC>atG	p.I2213M		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2213					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTAATTTGATCAATAACTTAG	0.338000													4	19					0	0	1	0	0
ZMAT2	153527	broad.mit.edu	37	5	140084063	140084063	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:140084063G>C	ENST00000274712.3	+	5	490	c.363G>C	c.(361-363)caG>caC	p.Q121H		NM_144723.1	NP_653324.1	Q96NC0	ZMAT2_HUMAN	zinc finger, matrin-type 2	121						nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(1)|liver(1)|lung(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTGGATCAGGTGAAGAAAC	0.453000													14	92					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46238887	46238887	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr22:46238887G>C	ENST00000252934.5	+	11	1519	c.1254G>C	c.(1252-1254)gtG>gtC	p.418_418insV	ATXN10_ENST00000381061.4_Missense_Mutation_p.354_354insV|ATXN10_ENST00000402380.3_Missense_Mutation_p.69_69insV	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	0					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		CCCAGTGGGTGATATATGCCA	0.438000													9	54					0	0	1	0	0
APPL2	55198	broad.mit.edu	37	12	105583914	105583914	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:105583914C>G	ENST00000258530.3	-	15	1486	c.1261G>C	c.(1261-1263)Gag>Cag	p.E421Q	APPL2_ENST00000539978.2_Missense_Mutation_p.E378Q|APPL2_ENST00000551662.1_Missense_Mutation_p.E427Q	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	421	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTTTCCATCTCTGAATTTTTC	0.413000													17	38					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130241706	130241706	+	Missense_Mutation	SNP	A	A	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:130241706A>C	ENST00000323301.4	+	12	1429	c.825A>C	c.(823-825)gaA>gaC	p.E275D	LRSAM1_ENST00000300417.6_Missense_Mutation_p.E275D|LRSAM1_ENST00000483302.1_3'UTR|LRSAM1_ENST00000373322.1_Missense_Mutation_p.E275D|LRSAM1_ENST00000373324.4_Missense_Mutation_p.E275D	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	275					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						GGCGCCTGGAACTGGGGCAGC	0.587000													13	58					0	0	1	0	0
ZDHHC20	253832	broad.mit.edu	37	13	22033206	22033206	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr13:22033206C>T	ENST00000400590.3	-	1	303	c.105G>A	c.(103-105)gtG>gtA	p.V35V	ZDHHC20_ENST00000542645.1_5'UTR|ZDHHC20_ENST00000422251.1_Silent_p.V35V|ZDHHC20_ENST00000415724.1_Silent_p.V35V|ZDHHC20_ENST00000382466.3_Silent_p.V35V|ZDHHC20_ENST00000320220.9_Silent_p.V35V			Q5W0Z9	ZDH20_HUMAN	zinc finger, DHHC-type containing 20	35						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9		all_cancers(29;8.1e-16)|all_epithelial(30;3.63e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000268)|Epithelial(112;0.000735)|OV - Ovarian serous cystadenocarcinoma(117;0.00517)|Lung(94;0.171)		CGCAGAGCTCCACCACGTACG	0.711000													10	56					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175086244	175086244	+	Silent	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:175086244C>A	ENST00000239462.4	+	10	2402	c.2289C>A	c.(2287-2289)gtC>gtA	p.V763V		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	763	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GTAGCACTGTCCTGACGGGCC	0.642000													25	94					2.39556e-15	2.78143e-15	1	1	0
ZNF425	155054	broad.mit.edu	37	7	148809257	148809257	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr7:148809257C>T	ENST00000378061.2	-	3	408	c.276G>A	c.(274-276)atG>atA	p.M92I	ZNF425_ENST00000484196.1_5'UTR	NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	92					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CAGTATTCTTCATGTTCAACT	0.368000													17	111					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113754397	113754397	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:113754397G>A	ENST00000552014.1	-	11	1442	c.927C>T	c.(925-927)ctC>ctT	p.L309L	SLC24A6_ENST00000553238.1_5'UTR|SLC24A6_ENST00000202831.3_Silent_p.L309L|SLC24A6_ENST00000546737.1_Silent_p.L253L			Q6J4K2	NCKX6_HUMAN		309					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						CCAGGGGATTGAGGGCCCGGA	0.587000													44	188					0	0	1	0	0
FOLR4	390243	broad.mit.edu	37	11	94039704	94039704	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:94039704G>A	ENST00000440961.2	+	2	208	c.164G>A	c.(163-165)tGc>tAc	p.C55Y		NM_001199206.1	NP_001186135.1	A6ND01	FOLR4_HUMAN	folate receptor 4, delta (putative)	55						extracellular region	folic acid binding|receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14						GACAATGCCTGCTGCACCCTC	0.552000													7	173					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10368996	10368996	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:10368996C>T	ENST00000393733.2	+	6	571	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	MRPL4_ENST00000307422.5_Silent_p.L182L|MRPL4_ENST00000253099.6_Silent_p.L182L|MRPL4_ENST00000590669.1_Silent_p.L182L|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000588502.1_Silent_p.L181L			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	182					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		GACCGTCAAGCTGGCCCAGGT	0.627000													10	55					0	0	1	0	0
HIST3H2A	92815	broad.mit.edu	37	1	228645204	228645204	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:228645204C>G	ENST00000366695.2	-	1	356	c.315G>C	c.(313-315)caG>caC	p.Q105H		NM_033445.2	NP_254280.1	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a	105					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|lung(3)|ovary(1)	5		Prostate(94;0.183)				GGACGCCACCCTGCGCGATGG	0.682000													31	101					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740854	37740854	+	Missense_Mutation	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:37740854A>G	ENST00000539465.1	+	15	2922	c.2329A>G	c.(2329-2331)Aag>Gag	p.K777E	FRMPD1_ENST00000536622.1_Missense_Mutation_p.K599E|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000541302.1_Missense_Mutation_p.K646E|FRMPD1_ENST00000377765.3_Missense_Mutation_p.K777E			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	777						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CGCGGCTGATAAGCTCACTCC	0.647000													8	47					0	0	1	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363392	21363392	+	RNA	SNP	G	G	A	rs28522842	by1000genomes	TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr22:21363392G>A	ENST00000452284.1	+	0	1059				THAP7-AS1_ENST00000436079.1_RNA|TUBA3FP_ENST00000422086.1_RNA	NR_027051.1																						GGGCCCCATCGAATCACAGGG	0.562000													5	424					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152293497	152293497	+	Missense_Mutation	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:152293497A>G	ENST00000243326.4	+	11	1835	c.1352A>G	c.(1351-1353)aAt>aGt	p.N451S	RIF1_ENST00000453091.2_Missense_Mutation_p.N451S|RIF1_ENST00000444746.2_Missense_Mutation_p.N451S|RIF1_ENST00000433166.2_3'UTR|RIF1_ENST00000428287.2_Missense_Mutation_p.N451S|RIF1_ENST00000430328.2_Missense_Mutation_p.N451S			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	451					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GCTAAGCAAAATAAACTTGTG	0.368000													4	51					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21054989	21054989	+	Missense_Mutation	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr18:21054989A>G	ENST00000339486.3	+	9	1708	c.1091A>G	c.(1090-1092)cAt>cGt	p.H364R	RIOK3_ENST00000577501.1_Missense_Mutation_p.H364R|RIOK3_ENST00000581585.1_Missense_Mutation_p.H348R	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	364	Protein kinase.				chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TTTATTGGCCATGATCAAGTT	0.338000													12	83					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42875133	42875133	+	Missense_Mutation	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr13:42875133A>G	ENST00000025301.2	+	8	2426	c.2251A>G	c.(2251-2253)Att>Gtt	p.I751V		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	751					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CAATCAAGCAATTATGGTGAC	0.418000													13	58					0	0	1	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229073	90229073	+	RNA	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:90229073G>A	ENST00000390278.2	+	0	29																											GCATGGACATGAGGGTCCCCG	0.562000													26	104					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23283320	23283320	+	RNA	SNP	C	C	A	rs149049629	by1000genomes	TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:23283320C>A	ENST00000560464.1	-	0	5097																											CAGCGTGTGCCTTTTCCTTCC	0.453000													4	38					0.184627	0.185701	1	1	0
GABRA1	2554	broad.mit.edu	37	5	161324132	161324132	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:161324132G>A	ENST00000428797.2	+	11	1430	c.1075G>A	c.(1075-1077)Gat>Aat	p.D359N	GABRA1_ENST00000393943.4_Missense_Mutation_p.D359N|GABRA1_ENST00000444819.1_Missense_Mutation_p.D359N|GABRA1_ENST00000023897.6_Missense_Mutation_p.D359N|GABRA1_ENST00000420560.1_Missense_Mutation_p.D359N|GABRA1_ENST00000437025.2_Missense_Mutation_p.D359N	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	359					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GAAAGTAAAGGATCCTCTTAT	0.423000													14	105					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140088	54140088	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:54140088C>G	ENST00000376650.1	+	3	473	c.422C>G	c.(421-423)gCa>gGa	p.A141G		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	141						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		AAGGTCCCTGCAAATGACTTC	0.532000													19	111					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9550142	9550142	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr18:9550142T>C	ENST00000400556.3	-	18	2528	c.2455A>G	c.(2455-2457)Acg>Gcg	p.T819A	PPP4R1_ENST00000400555.3_Missense_Mutation_p.T802A	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	819					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						ACTCCGAACGTTGGTGGTGTT	0.522000													15	42					0	0	1	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42975003	42975003	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:42975003G>A	ENST00000485511.1	+	5	771	c.592G>A	c.(592-594)Gaa>Aaa	p.E198K	PPP2R5D_ENST00000472118.1_Missense_Mutation_p.E190K|PPP2R5D_ENST00000394110.3_Missense_Mutation_p.E166K|PPP2R5D_ENST00000461010.1_Missense_Mutation_p.E92K	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	198					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TGACCCAGAGGAAGATGAGCC	0.607000													28	162					0	0	1	0	0
FAM27L	284123	broad.mit.edu	37	17	21826266	21826266	+	RNA	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:21826266G>C	ENST00000426869.3	+	0	449					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		AGGAATGGGAGATGGCAACAA	0.547000													9	47					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220102604	220102604	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:220102604T>C	ENST00000295759.7	-	15	1730	c.1417A>G	c.(1417-1419)Atc>Gtc	p.I473V	GLB1L_ENST00000409640.1_Missense_Mutation_p.I383V|GLB1L_ENST00000356283.3_Missense_Mutation_p.I383V|GLB1L_ENST00000392089.2_Missense_Mutation_p.I473V|GLB1L_ENST00000497855.1_5'UTR			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	473					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCACCAAGATATCCAGTTTG	0.478000													12	55					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42044968	42044968	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:42044968C>T	ENST00000220809.4	-	6	743	c.487G>A	c.(487-489)Ggg>Agg	p.G163R	PLAT_ENST00000519510.1_Intron|PLAT_ENST00000270189.6_Missense_Mutation_p.G163R|PLAT_ENST00000429710.2_Intron|PLAT_ENST00000352041.3_Missense_Mutation_p.G117R|PLAT_ENST00000429089.2_Missense_Mutation_p.G163R|PLAT_ENST00000524009.1_Intron	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	163	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity	p.G163R(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGCCTCCGCCCGCTGTAGGGC	0.652000													4	34					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74006034	74006034	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:74006034C>G	ENST00000301607.3	-	22	3505	c.3252G>C	c.(3250-3252)aaG>aaC	p.K1084N	EVPL_ENST00000586740.1_Missense_Mutation_p.K1106N	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1084	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TTTCCAGATTCTTCTCCACCT	0.597000													32	131					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175375841	175375841	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:175375841C>G	ENST00000367674.1	-	3	718	c.10G>C	c.(10-12)Gat>Cat	p.D4H	TNR_ENST00000263525.2_Missense_Mutation_p.D4H	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	4					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GTTTCCCCATCTGCCCCCATC	0.532000													19	102					0	0	1	0	0
GKAP1	80318	broad.mit.edu	37	9	86421439	86421439	+	Translation_Start_Site	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:86421439G>C	ENST00000376371.2	-	0	394				GKAP1_ENST00000376365.3_De_novo_Start_InFrame	NM_025211.3	NP_079487.2	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1						signal transduction	Golgi apparatus				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	14						CCATCGTAAAGATTTTTCTTT	0.423000													5	32					0	0	1	0	0
PRMT2	3275	broad.mit.edu	37	21	48078668	48078668	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr21:48078668G>C	ENST00000397637.1	+	7	1620	c.666G>C	c.(664-666)atG>atC	p.M222I	PRMT2_ENST00000397638.2_Missense_Mutation_p.M222I|PRMT2_ENST00000451211.2_Missense_Mutation_p.M222I|PRMT2_ENST00000458387.2_Intron|PRMT2_ENST00000291705.6_Intron|PRMT2_ENST00000355680.3_Missense_Mutation_p.M222I|PRMT2_ENST00000440086.1_Intron			P55345	ANM2_HUMAN	protein arginine methyltransferase 2	222	Interaction with ESR1.				developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			NS(1)|breast(3)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		TTGAGTTCATGATCGAGTCCA	0.567000													9	56					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121301912	121301912	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:121301912G>T	ENST00000297848.3	+	34	4413	c.4143G>T	c.(4141-4143)aaG>aaT	p.K1381N	COL14A1_ENST00000247781.3_Missense_Mutation_p.K1286N|COL14A1_ENST00000309791.4_Missense_Mutation_p.K1381N	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1381	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGGTGAGAAGGCAATGAACG	0.438000													10	85					0.000442599	0.000464059	1	1	0
DHX36	170506	broad.mit.edu	37	3	154002694	154002694	+	Missense_Mutation	SNP	A	A	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:154002694A>T	ENST00000496811.1	-	18	2194	c.2114T>A	c.(2113-2115)aTg>aAg	p.M705K	DHX36_ENST00000544526.1_Missense_Mutation_p.M691K|DHX36_ENST00000329463.5_Missense_Mutation_p.M691K|DHX36_ENST00000308361.6_Missense_Mutation_p.M705K	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	705						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AAAAAGAATCATTTTTCCAAT	0.418000													11	61					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160206325	160206325	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:160206325G>T	ENST00000392783.2	-	28	5252	c.4757C>A	c.(4756-4758)cCt>cAt	p.P1586H	BAZ2B_ENST00000392782.1_Missense_Mutation_p.P1550H|BAZ2B_ENST00000355831.2_Missense_Mutation_p.P1552H|BAZ2B_ENST00000343439.5_Missense_Mutation_p.P1486H	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1586					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CTGAGACTGAGGAGTCACCAA	0.448000													17	93					2.5808e-16	3.01674e-16	1	1	0
SLAMF7	57823	broad.mit.edu	37	1	160721236	160721236	+	Missense_Mutation	SNP	A	A	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:160721236A>C	ENST00000368043.3	+	5	908	c.871A>C	c.(871-873)Aat>Cat	p.N291H	SLAMF7_ENST00000458104.2_Intron|SLAMF7_ENST00000359331.4_Intron|SLAMF7_ENST00000441662.2_Missense_Mutation_p.N160H|SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000368042.3_Missense_Mutation_p.N184H|SLAMF7_ENST00000458602.2_Missense_Mutation_p.N144H	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	291					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCCTCACACTAATGTGAGTCC	0.468000													18	136					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70505386	70505386	+	Silent	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:70505386T>A	ENST00000310961.5	+	22	4198	c.3780T>A	c.(3778-3780)acT>acA	p.T1260T	LRRC7_ENST00000415775.2_Silent_p.T539T|LRRC7_ENST00000035383.5_Silent_p.T1255T			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1255						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CGAGGCCTACTCCTGTGAAGG	0.448000													5	78					0	0	1	0	0
RPS3	6188	broad.mit.edu	37	11	75115170	75115170	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:75115170G>C	ENST00000531188.1	+	5	519	c.457G>C	c.(457-459)Gtg>Ctg	p.V153L	RPS3_ENST00000527446.1_Missense_Mutation_p.V153L|RPS3_ENST00000534440.1_Intron|RPS3_ENST00000278572.6_Missense_Mutation_p.V169L|RPS3_ENST00000524851.1_Missense_Mutation_p.V153L|RPS3_ENST00000529285.1_Intron|RPS3_ENST00000526608.1_Missense_Mutation_p.V141L	NM_001005.4|NM_001260506.1|NM_001260507.1	NP_000996.2|NP_001247435.1|NP_001247436.1	P23396	RS3_HUMAN	ribosomal protein S3	153					activation of caspase activity|endocrine pancreas development|induction of apoptosis|negative regulation of DNA repair|negative regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus|ruffle membrane	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|iron-sulfur cluster binding|mRNA binding|NF-kappaB binding|protein kinase binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6						CATGAAGTTTGTGGATGGCCT	0.552000													19	75					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473609	53473609	+	RNA	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:53473609T>A	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							GCCACTCTCATTACATTGGAA	0.328000													12	75					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143614818	143614818	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:143614818C>T	ENST00000517894.1	+	25	4455	c.3561C>T	c.(3559-3561)ctC>ctT	p.L1187L	BAI1_ENST00000323289.5_Silent_p.L1187L			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1187					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					ACTGTATCCTCCGTAGAGAGG	0.677000													8	66					0	0	1	0	0
PEX12	5193	broad.mit.edu	37	17	33903191	33903191	+	Missense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:33903191C>A	ENST00000225873.4	-	3	1297	c.690G>T	c.(688-690)gaG>gaT	p.E230D		NM_000286.2	NP_000277.1	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	230					protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(8)	18				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTTTATCTTCTCACTAACAC	0.393000													9	42					0.000274275	0.000289327	1	1	0
RRAS2	22800	broad.mit.edu	37	11	14316369	14316369	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:14316369C>G	ENST00000545643.1	-	3	567	c.254G>C	c.(253-255)aGa>aCa	p.R85T	RRAS2_ENST00000532814.1_Missense_Mutation_p.R2T|RRAS2_ENST00000534746.1_Missense_Mutation_p.R2T|RRAS2_ENST00000537760.1_Missense_Mutation_p.R44T|RRAS2_ENST00000256196.4_Missense_Mutation_p.R79T|RRAS2_ENST00000414023.2_Missense_Mutation_p.R2T|RRAS2_ENST00000529237.1_Missense_Mutation_p.R2T|RRAS2_ENST00000526063.1_Missense_Mutation_p.R2T	NM_012250.5	NP_036382.2	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2	79						endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|endometrium(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	12				Epithelial(150;0.203)		ATACTGTTCTCTCATGGCTCC	0.393000													15	79					0	0	1	0	0
P2RY1	5028	broad.mit.edu	37	3	152553754	152553754	+	Silent	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:152553754A>G	ENST00000305097.3	+	1	1019	c.183A>G	c.(181-183)gtA>gtG	p.V61V		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	61					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			ACATCTTGGTATTCATCATCG	0.562000													16	87					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111753007	111753007	+	Splice_Site	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:111753007T>C	ENST00000374595.4	-	4	717	c.639_splice	c.e4+1	p.N213_splice	CTNNAL1_ENST00000325580.6_Splice_Site_p.N213_splice|CTNNAL1_ENST00000325551.4_Splice_Site_p.N213_splice			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	213					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		AATACATACATTTTGTCTATC	0.338000													8	29					0	0	1	0	0
TBPL1	9519	broad.mit.edu	37	6	134305519	134305519	+	Silent	SNP	A	A	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:134305519A>T	ENST00000237264.4	+	5	563	c.288A>T	c.(286-288)atA>atT	p.I96I	TBPL1_ENST00000367871.1_Silent_p.I96I|TBPL1_ENST00000477527.1_Intron	NM_001253676.1|NM_004865.3	NP_001240605.1|NP_004856.1	P62380	TBPL1_HUMAN	TBP-like 1	96					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	cytoplasm	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	6	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00591)|OV - Ovarian serous cystadenocarcinoma(155;0.00848)		TAAAGGTAATATTTACAGATT	0.323000													8	28					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11580751	11580751	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:11580751C>T	ENST00000294484.6	+	10	2346	c.2208C>T	c.(2206-2208)ttC>ttT	p.F736F	PTCHD2_ENST00000389575.3_Silent_p.F736F	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	736					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CAGGGCTGTTCGTCTCCATCC	0.657000													7	43					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9560902	9560902	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr20:9560902C>A	ENST00000378429.3	-	5	1426	c.880G>T	c.(880-882)Gaa>Taa	p.E294*	PAK7_ENST00000353224.5_Nonsense_Mutation_p.E294*|PAK7_ENST00000378423.1_Nonsense_Mutation_p.E294*	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	294	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ATCATCGGTTCCTGGAGTCCC	0.552000													13	165					7.93312e-07	8.68626e-07	1	1	0
SERTAD3	29946	broad.mit.edu	37	19	40947969	40947969	+	Missense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:40947969T>A	ENST00000322354.3	-	2	515	c.19A>T	c.(19-21)Agg>Tgg	p.R7W	SERTAD3_ENST00000392028.4_Missense_Mutation_p.R7W	NM_203344.2	NP_976219.1	Q9UJW9	SRTD3_HUMAN	SERTA domain containing 3	7					negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(4)|lung(2)	7			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGTGTTTCCTCTTCAAGCCT	0.557000													5	31					0	0	1	0	0
ASB6	140459	broad.mit.edu	37	9	132400134	132400134	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:132400134G>C	ENST00000277458.4	-	6	1366	c.1201C>G	c.(1201-1203)Ctg>Gtg	p.L401V	ASB6_ENST00000450050.2_Missense_Mutation_p.L322V|ASB6_ENST00000277459.4_3'UTR	NM_017873.3	NP_060343.1	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box containing 6	401	SOCS box.				intracellular signal transduction	cytoplasm				NS(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	15		Ovarian(14;0.00556)				CTGTCGGGCAGAGGCAGGGCT	0.617000													8	54					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59350639	59350639	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:59350639C>G	ENST00000348370.4	+	5	1689	c.1256C>G	c.(1255-1257)tCt>tGt	p.S419C	RNF111_ENST00000559209.1_Missense_Mutation_p.S419C|RNF111_ENST00000557998.1_Missense_Mutation_p.S419C|RNF111_ENST00000561186.1_Missense_Mutation_p.S419C|RNF111_ENST00000434298.1_Missense_Mutation_p.S419C	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	419	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		CCATCTACCTCTGAGCAGGCC	0.438000													47	202					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35835336	35835336	+	Missense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:35835336C>A	ENST00000187397.4	+	20	2781	c.2325C>A	c.(2323-2325)aaC>aaA	p.N775K	ARPP21_ENST00000417925.1_Missense_Mutation_p.N776K|ARPP21_ENST00000444190.1_Missense_Mutation_p.N756K|ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000458225.1_Missense_Mutation_p.N776K|ARPP21_ENST00000337271.5_Missense_Mutation_p.N756K	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	775						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CCCCTCAGAACAACCTTAGGC	0.542000													10	58					2.80697e-09	3.15329e-09	1	1	0
PRC1	9055	broad.mit.edu	37	15	91517833	91517833	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:91517833C>T	ENST00000361188.5	-	10	2543	c.1332G>A	c.(1330-1332)gaG>gaA	p.E444E	PRC1_ENST00000442656.2_Silent_p.E403E|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000394249.3_Silent_p.E444E|PRC1_ENST00000361919.3_Silent_p.E444E			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	444	Spectrin-fold.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCTTGGCTCTCTCTTTCTCCA	0.463000													34	162					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160388969	160388969	+	Missense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:160388969C>A	ENST00000368061.2	+	4	844	c.370C>A	c.(370-372)Ctg>Atg	p.L124M		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	124					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTCACGCCTCTGGCCTTCCT	0.662000													12	44					4.3838e-07	4.86152e-07	1	1	0
DPYSL5	56896	broad.mit.edu	37	2	27162927	27162927	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:27162927C>T	ENST00000288699.6	+	9	1134	c.976C>T	c.(976-978)Cac>Tac	p.H326Y	DPYSL5_ENST00000401478.1_Missense_Mutation_p.H326Y	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	326					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCATCAGATCACCGGCCTTT	0.527000													12	80					0	0	1	0	0
GNPAT	8443	broad.mit.edu	37	1	231403629	231403629	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:231403629G>T	ENST00000366647.4	+	9	1428	c.1259G>T	c.(1258-1260)gGa>gTa	p.G420V	GNPAT_ENST00000366646.3_Missense_Mutation_p.G359V	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	420					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				CAGGCATTTGGAGGGTTTCTC	0.428000													8	59					1	1	1	1	0
TMEM2	23670	broad.mit.edu	37	9	74313061	74313061	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:74313061G>C	ENST00000377044.4	-	20	3976	c.3437C>G	c.(3436-3438)tCt>tGt	p.S1146C	TMEM2_ENST00000396272.3_Missense_Mutation_p.S139C|TMEM2_ENST00000377066.5_Missense_Mutation_p.S1083C	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	1146						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ACATCCCTGAGATGAACAGTA	0.443000													18	101					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73071705	73071705	+	RNA	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chrX:73071705G>C	ENST00000429829.1	-	0	883					NR_001564.2																						CTTAACTGCAGAGTCATTCTC	0.463000													4	68					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142567884	142567884	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:142567884C>G	ENST00000389484.3	-	2	1140	c.169G>C	c.(169-171)Gac>Cac	p.D57H	LRP1B_ENST00000486364.1_5'UTR	NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	57	LDL-receptor class A 1.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAGGGCAGTCAGGGTCCCCA	0.443000										TSP Lung(27;0.18)			6	34					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43307320	43307320	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:43307320G>A	ENST00000361428.2	-	10	4493	c.4416C>T	c.(4414-4416)atC>atT	p.I1472I	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1472	Pro-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTGGAGCCAAGATAGCATTTG	0.537000													9	41					0	0	1	0	0
NUFIP2	57532	broad.mit.edu	37	17	27614359	27614359	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:27614359T>C	ENST00000225388.4	-	2	711	c.653A>G	c.(652-654)tAt>tGt	p.Y218C	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	218						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			AGGAGTTGTATATCCGCTCTC	0.383000													17	131					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165548079	165548079	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:165548079G>C	ENST00000264381.3	-	2	909	c.743C>G	c.(742-744)gCc>gGc	p.A248G	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	248					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TTGCAGAATGGCTCTGGTGAA	0.438000													14	61					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159554629	159554629	+	Splice_Site	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:159554629G>C	ENST00000307765.5	+	12	1222		c.e12+1		RXFP1_ENST00000470033.1_Splice_Site|RXFP1_ENST00000343542.5_Intron|RXFP1_ENST00000448688.2_Splice_Site|RXFP1_ENST00000460056.2_Splice_Site	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1							integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TGTCACAATTGTAAGACTGAT	0.294000													9	54					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21626537	21626537	+	Silent	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:21626537T>A	ENST00000444129.2	-	12	1863	c.1395A>T	c.(1393-1395)gtA>gtT	p.V465V	RECQL_ENST00000421138.2_Silent_p.V465V	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	465					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						CTGAGTTCCATACTTCATCAA	0.323000								Other identified genes with known or suspected DNA repair function					10	37					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16465736	16465736	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:16465736G>A	ENST00000308683.2	-	1	165	c.39C>T	c.(37-39)ttC>ttT	p.F13F		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	13						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CCGCGTCGCGGAACGCCACCC	0.642000													13	108					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982292	7982292	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:7982292G>A	ENST00000328600.2	-	2	1028	c.867C>T	c.(865-867)ctC>ctT	p.L289L		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	289	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGGTGGTGATGAGAAGGGAGC	0.542000													27	114					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57000035	57000035	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:57000035G>A	ENST00000179765.5	-	13	2364	c.2165C>T	c.(2164-2166)tCc>tTc	p.S722F	BAZ2A_ENST00000549884.1_Missense_Mutation_p.S752F|BAZ2A_ENST00000379441.3_Missense_Mutation_p.S724F|BAZ2A_ENST00000551812.1_Missense_Mutation_p.S754F			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	754	Lys-rich.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						ACCTACCTTGGATTTCTTCTT	0.393000													11	35					0	0	1	0	0
ZNF724P	440519	broad.mit.edu	37	19	23405636	23405636	+	Missense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:23405636T>A	ENST00000418100.1	-	4	1528	c.1411A>T	c.(1411-1413)Att>Ttt	p.I471F																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						CCAGTATGAATTATCCTATGT	0.363000													16	52					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34097827	34097827	+	Splice_Site	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr20:34097827G>A	ENST00000397527.1	+	34	7729	c.7008_splice	c.e34-1	p.D2337_splice	CEP250_ENST00000342580.4_Splice_Site_p.D2281_splice	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2337					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCTTCCTTAGGATGGGAGAGG	0.498000													12	69					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	79245622	79245622	+	Missense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:79245622G>C	ENST00000566780.1	+	9	1540	c.1174G>C	c.(1174-1176)Gag>Cag	p.E392Q	WWOX_ENST00000402655.2_Missense_Mutation_p.R176T|WWOX_ENST00000539474.2_Missense_Mutation_p.K201N|WWOX_ENST00000406884.2_Missense_Mutation_p.E212Q	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	392	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TCAGAGCGAAGAGACGGCCCG	0.617000													10	73					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33629222	33629222	+	Missense_Mutation	SNP	G	G	A	rs143526946		TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr13:33629222G>A	ENST00000380099.3	+	3	1377	c.1369G>A	c.(1369-1371)Gca>Aca	p.A457T	KL_ENST00000487852.1_3'UTR|KL_ENST00000426690.2_Missense_Mutation_p.A150T	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	457	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CGGGTATACCGCATGGTCCCT	0.527000													4	101					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158549000	158549000	+	Silent	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:158549000G>T	ENST00000368150.1	-	1	689	c.690C>A	c.(688-690)atC>atA	p.I230I		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					CAGTCAGGATGATGAGCAGAA	0.488000													15	48					0.000219431	0.000232893	1	1	0
CPSF1	29894	broad.mit.edu	37	8	145623977	145623977	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:145623977C>G	ENST00000349769.3	-	18	1784	c.1690G>C	c.(1690-1692)Gaa>Caa	p.E564Q		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	564					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TCGTCTGCTTCAGGGGTGGTG	0.657000													30	169					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160176488	160176488	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:160176488G>A	ENST00000358372.4	+	8	2793	c.1036G>A	c.(1036-1038)Gaa>Aaa	p.E346K	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	346					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		CACGGGCAGTGAAAACTCTCT	0.507000													14	86					0	0	1	0	0
TMEM87A	25963	broad.mit.edu	37	15	42564296	42564296	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:42564296T>C	ENST00000389834.4	-	2	434	c.170A>G	c.(169-171)aAg>aGg	p.K57R	TMEM87A_ENST00000307216.6_Missense_Mutation_p.K57R|TMEM87A_ENST00000568432.1_5'UTR|TMEM87A_ENST00000448392.1_Intron	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A	57						integral to membrane				breast(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		GAAGAGGATCTTTCCAAAACT	0.284000													8	52					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10368995	10368995	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:10368995G>T	ENST00000393733.2	+	6	570	c.543G>T	c.(541-543)aaG>aaT	p.K181N	MRPL4_ENST00000307422.5_Missense_Mutation_p.K181N|MRPL4_ENST00000253099.6_Missense_Mutation_p.K181N|MRPL4_ENST00000590669.1_Missense_Mutation_p.K181N|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000588502.1_Missense_Mutation_p.K180N			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	181					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		TGACCGTCAAGCTGGCCCAGG	0.632000													11	54					5.50884e-06	5.99389e-06	1	1	0
TP53	7157	broad.mit.edu	37	17	7574000	7574000	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:7574000C>A	ENST00000269305.4	-	10	1216	c.1027G>T	c.(1027-1029)Gag>Tag	p.E343*	TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_3'UTR|TP53_ENST00000445888.2_Nonsense_Mutation_p.E343*	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	343	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		E -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E343*(8)|p.0?(8)|p.R342_N345delRELN(1)|p.I332fs*5(1)|p.?(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCATTCAGCTCTCGGAACATC	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	39					7.48243e-07	8.24497e-07	1	1	0
ARSJ	79642	broad.mit.edu	37	4	114824718	114824718	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:114824718G>A	ENST00000315366.7	-	2	1378	c.512C>T	c.(511-513)aCg>aTg	p.T171M	ARSJ_ENST00000541197.1_Missense_Mutation_p.T171M	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	171						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		GACCATATGCGTTGAATATCC	0.448000													23	120					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33495214	33495214	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr10:33495214C>T	ENST00000374816.3	-	11	1966	c.1827G>A	c.(1825-1827)aaG>aaA	p.K609K	NRP1_ENST00000395995.1_Intron|NRP1_ENST00000374823.5_Intron|NRP1_ENST00000374822.4_Intron|NRP1_ENST00000374867.2_Intron|NRP1_ENST00000265371.4_Intron|NRP1_ENST00000374821.5_Intron|NRP1_ENST00000466932.1_Intron			O14786	NRP1_HUMAN	neuropilin 1	0					axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	CTGCCCATCTCTTCTTTTTCT	0.483000													11	43					0	0	1	0	0
LY6D	8581	broad.mit.edu	37	8	143867012	143867012	+	Silent	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:143867012C>A	ENST00000301263.4	-	2	219	c.144G>T	c.(142-144)acG>acT	p.T48T	RP11-706C16.8_ENST00000510610.2_RNA|LY6D_ENST00000518434.1_5'UTR	NM_003695.2	NP_003686.1	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D	48	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding			large_intestine(1)|lung(3)|prostate(1)	5	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CACCTGTGTTCGTGGTCTTGC	0.647000													13	81					0.000151284	0.00016256	1	1	0
PRTG	283659	broad.mit.edu	37	15	56032808	56032808	+	Missense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:56032808C>A	ENST00000389286.4	-	2	216	c.169G>T	c.(169-171)Gtt>Ttt	p.V57F	PRTG_ENST00000561292.1_Missense_Mutation_p.V57F	NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	57	Ig-like 1.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		CAATCTAAAACGACTGGGTCC	0.408000													11	94					9.70103e-10	1.09691e-09	1	1	0
PLEKHG4	25894	broad.mit.edu	37	16	67316154	67316154	+	Silent	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:67316154A>G	ENST00000360461.5	+	8	3690	c.1155A>G	c.(1153-1155)ctA>ctG	p.L385L	PLEKHG4_ENST00000379344.3_Silent_p.L385L|PLEKHG4_ENST00000427155.2_Silent_p.L385L|PLEKHG4_ENST00000450733.1_Silent_p.L304L	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	385					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		AGCAGGTGCTAGACTCGCCAT	0.602000													7	52					0	0	1	0	0
HAPLN3	145864	broad.mit.edu	37	15	89421324	89421324	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:89421324G>A	ENST00000359595.3	-	5	1174	c.960C>T	c.(958-960)agC>agT	p.S320S	HAPLN3_ENST00000562889.1_Silent_p.S382S	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	320	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					GGTAGCGGACGCTACCATCTG	0.642000													28	109					0	0	1	0	0
TSLP	85480	broad.mit.edu	37	5	110409267	110409267	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:110409267C>T	ENST00000420978.2	+	4	1697	c.275C>T	c.(274-276)tCg>tTg	p.S92L	TSLP_ENST00000344895.3_Missense_Mutation_p.S92L|TSLP_ENST00000379706.4_5'UTR			Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin	92						extracellular space	cytokine activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		GGCTGCGCGTCGCTCGCCAAA	0.517000													25	172					0	0	1	0	0
EDDM3A	10876	broad.mit.edu	37	14	21215972	21215972	+	Missense_Mutation	SNP	G	G	A	rs149270684	byFrequency	TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr14:21215972G>A	ENST00000326842.2	+	2	360	c.233G>A	c.(232-234)cGt>cAt	p.R78H		NM_006683.4	NP_006674.2	Q14507	EP3A_HUMAN	epididymal protein 3A	78					sperm displacement	extracellular space				breast(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						AAAATTCAGCGTGCATGCATC	0.438000													6	41					0	0	1	0	0
IFNL3	282617	broad.mit.edu	37	19	39734290	39734290	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:39734290G>T	ENST00000413851.2	-	5	611	c.573C>A	c.(571-573)agC>agA	p.S191R		NM_172139.2	NP_742151.2			interferon, lambda 3									p.S191S(1)									ACAGGTCCCCGCTGGCAACAC	0.527000													3	16					0.115264	0.117298	1	1	0
BARD1	580	broad.mit.edu	37	2	215610519	215610519	+	Silent	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:215610519T>C	ENST00000260947.4	-	8	1871	c.1737A>G	c.(1735-1737)tcA>tcG	p.S579S	BARD1_ENST00000449967.2_Silent_p.S435S	NM_000465.2	NP_000456.2	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	579	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCTGTTGTTCTGAAGACAGCC	0.398000									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				17	127					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20116857	20116857	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:20116857T>C	ENST00000397165.2	-	4	1614	c.1454A>G	c.(1453-1455)aAa>aGa	p.K485R	ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000597972.1_Missense_Mutation_p.K491R|ZNF682_ENST00000595736.1_Missense_Mutation_p.K409R|ZNF682_ENST00000397162.1_Missense_Mutation_p.K453R|ZNF682_ENST00000358523.5_Missense_Mutation_p.K453R	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TTCCCCACATTTTTTATACTT	0.338000													15	66					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132407666	132407666	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:132407666C>T	ENST00000337331.5	-	21	3039	c.2953G>A	c.(2953-2955)Gcc>Acc	p.A985T	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	985					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGGGACTGGGCTACTCTTGGG	0.473000													19	114					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53609155	53609155	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:53609155T>C	ENST00000425354.2	-	5	884	c.397A>G	c.(397-399)Atc>Gtc	p.I133V	RARG_ENST00000394426.1_Missense_Mutation_p.I133V|RARG_ENST00000338561.5_Missense_Mutation_p.I122V|RARG_ENST00000327550.3_Missense_Mutation_p.I61V|RARG_ENST00000543726.1_Missense_Mutation_p.I111V|RARG_ENST00000543762.1_5'UTR	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	133					canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TTGTTGATGATACAGTTTTTG	0.537000													18	95					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154557382	154557382	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:154557382G>A	ENST00000368474.4	-	15	3780	c.3581C>T	c.(3580-3582)aCg>aTg	p.T1194M	ADAR_ENST00000292205.5_Missense_Mutation_p.T1237M|ADAR_ENST00000368471.3_Missense_Mutation_p.T899M	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	1194	A to I editase.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTTCTTGGCCGTCTCGTAGTC	0.468000													20	90					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114515930	114515930	+	Silent	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:114515930A>G	ENST00000369558.1	+	16	3661	c.3429A>G	c.(3427-3429)gcA>gcG	p.A1143A	HIPK1_ENST00000340480.4_Silent_p.A769A|HIPK1_ENST00000406344.1_Silent_p.A749A|HIPK1_ENST00000369561.4_Silent_p.A1109A|HIPK1_ENST00000369554.2_Silent_p.A1098A|HIPK1_ENST00000369553.1_Silent_p.A749A|HIPK1_ENST00000426820.2_Silent_p.A1143A|HIPK1_ENST00000369555.2_Silent_p.A1098A			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	1143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCATGCTGCAGCCTATACCA	0.577000													15	87					0	0	1	0	0
CEP76	79959	broad.mit.edu	37	18	12691416	12691416	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr18:12691416C>T	ENST00000262127.2	-	7	1100	c.875G>A	c.(874-876)aGa>aAa	p.R292K	CEP76_ENST00000423709.2_Missense_Mutation_p.R217K|RP11-973H7.2_ENST00000585331.1_RNA	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	292					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAAATATTCTCTCCACCACTG	0.328000													18	94					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170201117	170201117	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:170201117G>A	ENST00000231706.4	-	6	1416	c.1101C>T	c.(1099-1101)gaC>gaT	p.D367D	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	367						integral to membrane	amino acid transmembrane transporter activity	p.D367D(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AAAGGAGCCCGTCACCAGCCA	0.537000											OREG0015917	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	49					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144811226	144811226	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:144811226C>T	ENST00000367545.3	+	30	4154	c.4154C>T	c.(4153-4155)tCa>tTa	p.S1385L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1385	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding	p.S1385L(1)		NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCAGAGATCTCAGCCCATGAG	0.418000													14	101					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74006522	74006522	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:74006522C>A	ENST00000301607.3	-	22	3017	c.2764G>T	c.(2764-2766)Gaa>Taa	p.E922*	EVPL_ENST00000586740.1_Nonsense_Mutation_p.E944*	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	922	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTCTCCTCTTCCAGCTGGGCC	0.652000													6	50					0.000157383	0.00016807	1	1	0
OR2M4	26245	broad.mit.edu	37	1	248402918	248402918	+	Missense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:248402918T>A	ENST00000306687.1	+	1	688	c.688T>A	c.(688-690)Tct>Act	p.S230T		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCACATGGGCTCTGGGGAAAG	0.488000													6	50					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657852	197657852	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:197657852T>C	ENST00000263956.3	-	3	328	c.239A>G	c.(238-240)aAg>aGg	p.K80R	GTF3C3_ENST00000409364.3_Missense_Mutation_p.K80R	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	80						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						GTGAACTGACTTCCTCACTCC	0.463000													11	83					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146267421	146267421	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:146267421C>G	ENST00000367503.3	-	7	1667	c.1269G>C	c.(1267-1269)aaG>aaC	p.K423N	SHPRH_ENST00000438092.2_Missense_Mutation_p.K423N|SHPRH_ENST00000275233.7_Missense_Mutation_p.K423N|SHPRH_ENST00000367505.2_Missense_Mutation_p.K423N	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	423					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGATTTCTGTCTTTTTCAGTT	0.333000													4	46					0	0	1	0	0
MPP2	4355	broad.mit.edu	37	17	41958118	41958118	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:41958118C>T	ENST00000269095.4	-	10	1395	c.1091G>A	c.(1090-1092)cGc>cAc	p.R364H	MPP2_ENST00000536246.1_Missense_Mutation_p.R353H|MPP2_ENST00000523501.1_Missense_Mutation_p.R353H|MPP2_ENST00000520305.1_Missense_Mutation_p.R225H|MPP2_ENST00000518766.1_Missense_Mutation_p.R409H|MPP2_ENST00000461854.1_Missense_Mutation_p.R388H|MPP2_ENST00000377184.3_Missense_Mutation_p.R381H	NM_001278370.1|NM_001278381.1|NM_005374.3	NP_001265299.1|NP_001265310.1|NP_005365.3	Q14168	MPP2_HUMAN	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	388					signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(4)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CTTCAGGCTGCGCCGTCCCAC	0.612000											OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	67					0	0	1	0	0
NDRG3	57446	broad.mit.edu	37	20	35282014	35282014	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr20:35282014G>A	ENST00000373803.2	-	17	1132	c.1076C>T	c.(1075-1077)tCt>tTt	p.S359F	NDRG3_ENST00000540765.1_Missense_Mutation_p.S242F|NDRG3_ENST00000373773.3_Missense_Mutation_p.S251F|NDRG3_ENST00000359675.2_Missense_Mutation_p.S334F|NDRG3_ENST00000349004.1_Missense_Mutation_p.S346F			Q9UGV2	NDRG3_HUMAN	NDRG family member 3	346					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Myeloproliferative disorder(115;0.00878)				GCTGGTGACAGACCGGCTGAA	0.552000													10	44					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8133718	8133718	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:8133718G>T	ENST00000315684.8	-	17	2834	c.2827C>A	c.(2827-2829)Ccc>Acc	p.P943T		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	943					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						AGGTGAGGGGGGAATTCACAT	0.517000													6	67					0.0215528	0.0221942	1	1	0
ADAM10	102	broad.mit.edu	37	15	58919941	58919941	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:58919941T>C	ENST00000260408.3	-	10	1761	c.1318A>G	c.(1318-1320)Ata>Gta	p.I440V	ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000396140.2_Missense_Mutation_p.I139V	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	440	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		ACTTGGCTTATATTTCTAATA	0.318000													9	49					0	0	1	0	0
MED10	84246	broad.mit.edu	37	5	6377334	6377334	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:6377334T>C	ENST00000255764.3	-	2	261	c.151A>G	c.(151-153)Att>Gtt	p.I51V		NM_032286.2	NP_115662.2	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	51					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				kidney(1)|large_intestine(1)|ovary(1)|prostate(1)|urinary_tract(1)	5						CACTTGTCAATATCCTGTAAG	0.398000													11	74					0	0	1	0	0
FOSB	2354	broad.mit.edu	37	19	45974060	45974060	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:45974060G>A	ENST00000353609.3	+	2	892	c.300G>A	c.(298-300)ccG>ccA	p.P100P	FOSB_ENST00000592436.1_Silent_p.P100P|ERCC1_ENST00000423698.2_Intron|FOSB_ENST00000586615.1_Silent_p.P51P|FOSB_ENST00000591858.1_Silent_p.P61P|FOSB_ENST00000592811.1_Silent_p.P51P|FOSB_ENST00000590335.1_Silent_p.P100P|FOSB_ENST00000417353.2_Silent_p.P100P|FOSB_ENST00000585836.1_Silent_p.P61P|FOSB_ENST00000443841.2_Intron	NM_006732.2	NP_006723.2	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	100					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	13		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		ACGACATGCCGGGAACCAGCT	0.662000													16	147					0	0	1	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6089554	6089554	+	Nonsense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr7:6089554T>A	ENST00000199389.6	-	3	546	c.400A>T	c.(400-402)Aga>Tga	p.R134*	EIF2AK1_ENST00000536084.1_Intron	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	134			R -> K (in dbSNP:rs55744865).		negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TGACGAACTCTCTCTTTAGCA	0.338000													25	89					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140261916	140261916	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:140261916C>T	ENST00000289272.2	+	1	63	c.63C>T	c.(61-63)ctC>ctT	p.L21L	PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.L21L|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGATCCTCGCAGCCTGGG	0.592000													35	156					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31625400	31625400	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr20:31625400C>G	ENST00000349552.1	+	8	702	c.702C>G	c.(700-702)atC>atG	p.I234M		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	234						extracellular region	lipid binding										GCAAAACCATCAAGCTTGCTG	0.607000													4	85					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129195646	129195646	+	Splice_Site	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:129195646T>A	ENST00000296266.3	+	12	1492		c.e12+2		IFT122_ENST00000349441.2_Splice_Site|IFT122_ENST00000348417.2_Splice_Site|IFT122_ENST00000507564.1_Splice_Site|IFT122_ENST00000347300.2_Splice_Site|IFT122_ENST00000504021.1_Splice_Site|IFT122_ENST00000440957.2_Splice_Site|IFT122_ENST00000431818.2_Splice_Site	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)						camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						AGCAGAAAGGTAAGAGGCAGG	0.512000													11	54					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554241	135554241	+	Missense_Mutation	SNP	A	A	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:135554241A>T	ENST00000372146.4	+	2	1799	c.1235A>T	c.(1234-1236)aAt>aTt	p.N412I	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	412					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCAGGGCTGAATGTTCACAAT	0.453000													30	102					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123091839	123091839	+	Missense_Mutation	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:123091839A>G	ENST00000264501.4	+	3	410	c.37A>G	c.(37-39)Ata>Gta	p.I13V	KIAA1109_ENST00000388738.3_Missense_Mutation_p.I13V|KIAA1109_ENST00000455637.1_Missense_Mutation_p.I13V			Q2LD37	K1109_HUMAN	KIAA1109	13					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TGTTCCTAGTATAACTCAATT	0.299000													4	31					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774189	40774189	+	Silent	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:40774189G>T	ENST00000602553.1	-	5	1380	c.1086C>A	c.(1084-1086)ctC>ctA	p.L362L	ZNF658_ENST00000377626.3_Silent_p.L362L|ZNF658_ENST00000441795.1_Silent_p.L360L			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ATTTCTGGTAGAGGGCATCTG	0.368000													35	172					1.57019e-19	1.84791e-19	1	1	0
SHC4	399694	broad.mit.edu	37	15	49135689	49135689	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:49135689T>C	ENST00000332408.4	-	10	1828	c.1400A>G	c.(1399-1401)aAt>aGt	p.N467S	SHC4_ENST00000396535.3_Missense_Mutation_p.N224S|SHC4_ENST00000537958.1_Missense_Mutation_p.N181S	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	467	CH1.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		AGCCTGTGTATTAATGTAGCA	0.512000													17	79					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131953847	131953847	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:131953847G>T	ENST00000378823.3	+	21	3651	c.2833G>T	c.(2833-2835)Gaa>Taa	p.E945*	RAD50_ENST00000265335.6_Nonsense_Mutation_p.E1084*	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	1084					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTATGAAGAAGAAATTATTCA	0.323000								Homologous recombination					18	109					8.10497e-08	9.0462e-08	1	1	0
SIPA1L3	23094	broad.mit.edu	37	19	38590602	38590602	+	Splice_Site	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:38590602C>T	ENST00000222345.6	+	5	2175	c.1665_splice	c.e5-1	p.L556_splice		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	556					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCTTGAGTAGCTCATCACCCT	0.552000													25	66					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23381605	23381605	+	Silent	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:23381605T>C	ENST00000400181.4	+	6	938	c.834T>C	c.(832-834)cgT>cgC	p.R278R	KDM1A_ENST00000542151.1_Silent_p.R278R|KDM1A_ENST00000356634.3_Silent_p.R258R|RP1-184J9.2_ENST00000427154.1_RNA	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	258					blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						ATTTAGAGCGTCATGGTCTTA	0.368000													23	152					0	0	1	0	0
KLF1	10661	broad.mit.edu	37	19	12995779	12995779	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:12995779G>T	ENST00000264834.4	-	3	1049	c.1009C>A	c.(1009-1011)Cgc>Agc	p.R337S		NM_006563.3	NP_006554.1	Q13351	KLF1_HUMAN	Kruppel-like factor 1 (erythroid)	337					erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|skin(1)	5		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGAAGGGGCGCTGCCCCGTG	0.657000													11	62					0.00136819	0.00142589	1	1	0
GPM6A	2823	broad.mit.edu	37	4	176556071	176556071	+	Silent	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:176556071G>C	ENST00000280187.7	-	8	867	c.822C>G	c.(820-822)ctC>ctG	p.L274L	GPM6A_ENST00000515090.1_Silent_p.L267L|GPM6A_ENST00000393658.2_Silent_p.L274L|GPM6A_ENST00000506219.1_5'UTR|GPM6A_ENST00000506894.1_Silent_p.L263L	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	274						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		TGTATGCATTGAGCCGCTCTT	0.428000													11	66					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185962417	185962417	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:185962417C>T	ENST00000271588.4	+	23	3710	c.3481C>T	c.(3481-3483)Cag>Tag	p.Q1161*	HMCN1_ENST00000485744.1_3'UTR|HMCN1_ENST00000367492.2_Nonsense_Mutation_p.Q1161*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1161	Ig-like C2-type 8.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GAATGTGACTCAGGCTGTCAA	0.423000													11	60					0	0	1	0	0
NOP58	51602	broad.mit.edu	37	2	203155110	203155110	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:203155110C>T	ENST00000264279.5	+	7	790	c.564C>T	c.(562-564)ggC>ggT	p.G188G		NM_015934.3	NP_057018.1	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein	188					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2)	16						AATGGTATGGCTGGCATTTCC	0.313000													9	75					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75849918	75849918	+	Silent	SNP	A	A	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr10:75849918A>T	ENST00000211998.4	+	10	1408	c.1314A>T	c.(1312-1314)atA>atT	p.I438I	VCL_ENST00000372755.3_Silent_p.I438I|VCL_ENST00000478896.2_Intron|VCL_ENST00000417648.2_Intron	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	438	3 X 112 AA tandem repeats.|N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					TTGGGGAAATATCTGCTCTGA	0.398000													16	78					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576904	7576904	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:7576904G>A	ENST00000420246.2	-	9	1074	c.942C>T	c.(940-942)tcC>tcT	p.S314S	TP53_ENST00000359597.4_Silent_p.S314S|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Silent_p.S314S|TP53_ENST00000445888.2_Silent_p.S314S|TP53_ENST00000269305.4_Silent_p.S314S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	314	Interaction with CARM1.|Interaction with HIPK1 (By similarity).		S -> F (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.S315fs*22(2)|p.S315fs*30(1)|p.?(1)|p.S314fs*25(1)|p.L308fs*15(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGGGGAGAGGAGCTGGTGT	0.478000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	40					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461393	141461393	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:141461393G>A	ENST00000389328.4	-	2	388	c.374C>T	c.(373-375)tCc>tTc	p.S125F	TRAPPC9_ENST00000438773.2_Missense_Mutation_p.S27F|TRAPPC9_ENST00000389327.3_Missense_Mutation_p.S27F	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	27					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GTTCTCCTCGGAGACGATGCC	0.557000													9	69					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123091841	123091841	+	Silent	SNP	A	A	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:123091841A>C	ENST00000264501.4	+	3	412	c.39A>C	c.(37-39)atA>atC	p.I13I	KIAA1109_ENST00000388738.3_Silent_p.I13I|KIAA1109_ENST00000455637.1_Silent_p.I13I			Q2LD37	K1109_HUMAN	KIAA1109	13					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TTCCTAGTATAACTCAATTAG	0.294000													4	31					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322321	55322321	+	Missense_Mutation	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:55322321G>T	ENST00000314644.2	+	1	539	c.539G>T	c.(538-540)tGc>tTc	p.C180F		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GTGGCCATTTGCAAGCCCTTG	0.498000										HNSCC(20;0.049)			19	83					3.51602e-12	4.00178e-12	1	1	0
COL8A1	1295	broad.mit.edu	37	3	99514668	99514668	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:99514668C>T	ENST00000261037.3	+	5	2303	c.1923C>T	c.(1921-1923)aaC>aaT	p.N641N	COL8A1_ENST00000273342.4_Silent_p.N641N	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	641	C1q.|Nonhelical region (NC1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						TGCTGTATAACGGCAGACAGA	0.552000													11	51					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1080567	1080567	+	Silent	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:1080567T>C	ENST00000441003.2	+	9	1236	c.1209T>C	c.(1207-1209)gaT>gaC	p.D403D	MUC2_ENST00000359061.5_Silent_p.D403D	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	403	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCACCTTCGATGGGAAGACGT	0.647000													7	29					0	0	1	0	0
SPANXN4	441525	broad.mit.edu	37	X	142113849	142113849	+	Missense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chrX:142113849T>A	ENST00000370504.3	+	1	132	c.49T>A	c.(49-51)Tgt>Agt	p.C17S	SPANXN4_ENST00000446864.1_Missense_Mutation_p.C17S			Q5MJ08	SPXN4_HUMAN	SPANX family, member N4	17										endometrium(2)|large_intestine(2)|lung(3)|ovary(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGAGCCCCTGTGAATCTAA	0.428000													3	8					0	0	1	0	0
GALNT9	50614	broad.mit.edu	37	12	132683769	132683769	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:132683769C>T	ENST00000328957.8	-	9	1446	c.1447G>A	c.(1447-1449)Gag>Aag	p.E483K	GALNT9_ENST00000535228.1_Missense_Mutation_p.E234K|GALNT9_ENST00000541995.1_Missense_Mutation_p.E117K|GALNT9_ENST00000397325.2_Missense_Mutation_p.E117K	NM_001122636.1	NP_001116108.1	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)	483	Ricin B-type lectin.				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(5)	9	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		TCGCCGTCCTCCGCTCCCTGG	0.657000													7	57					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20523043	20523043	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:20523043G>A	ENST00000359062.3	+	1	865	c.825G>A	c.(823-825)ctG>ctA	p.L275L	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.L275L(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627000													7	60					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236881	140236881	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:140236881G>A	ENST00000307360.5	+	1	1248	c.1248G>A	c.(1246-1248)agG>agA	p.R416R	PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Silent_p.R416R|PCDHA8_ENST00000531613.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCGAGAGGGTGTCGGCCT	0.637000													55	94					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88260246	88260246	+	Missense_Mutation	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr10:88260246T>C	ENST00000298767.5	-	3	1226	c.754A>G	c.(754-756)Att>Gtt	p.I252V		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	252	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						AAACTTAAAATACAGTCTTCT	0.353000													9	66					0	0	1	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22830863	22830863	+	Silent	SNP	G	G	A	rs111483402	byFrequency	TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr10:22830863G>A	ENST00000376573.4	-	8	1134	c.906C>T	c.(904-906)ggC>ggT	p.G302G	PIP4K2A_ENST00000545335.1_Silent_p.G243G|PIP4K2A_ENST00000323883.7_Silent_p.G162G	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	302	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						CATCGCTCTCGCCCTCCTCCT	0.602000													7	63					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124401152	124401152	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:124401152G>A	ENST00000409039.3	+	62	10542	c.10517G>A	c.(10516-10518)cGg>cAg	p.R3506Q		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3506	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCCCAAGGACGGCAGTTTATT	0.438000													9	36					0	0	1	0	0
SLC52A1	55065	broad.mit.edu	37	17	4936430	4936430	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:4936430G>C	ENST00000424747.1	-	5	1881	c.1169C>G	c.(1168-1170)tCa>tGa	p.S390*	SLC52A1_ENST00000512825.2_Missense_Mutation_p.H349D|SLC52A1_ENST00000254853.5_Nonsense_Mutation_p.S390*	NM_001104577.1	NP_001098047.1	Q9NWF4	RFT_HUMAN	solute carrier family 52 (riboflavin transporter), member 1	390						integral to plasma membrane	receptor activity|riboflavin transporter activity										CTTCACATATGAGAACACACA	0.622000													8	47					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85788103	85788103	+	Missense_Mutation	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:85788103C>T	ENST00000233838.3	-	2	129	c.49G>A	c.(49-51)Gta>Ata	p.V17I	GGCX_ENST00000430215.3_Intron	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	17					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TCTTTCTGTACTTTATCTGCA	0.498000													19	96					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101024772	101024772	+	Missense_Mutation	SNP	C	C	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:101024772C>A	ENST00000284382.4	-	6	813	c.390G>T	c.(388-390)aaG>aaT	p.K130N	CERS3_ENST00000538112.2_Missense_Mutation_p.K130N|CERS3_ENST00000394113.1_Missense_Mutation_p.K130N|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	130	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CCTGGAATTTCTTCAGCCTGG	0.517000													14	52					1.52009e-12	1.75317e-12	1	1	0
IFT172	26160	broad.mit.edu	37	2	27684212	27684212	+	Missense_Mutation	SNP	C	C	T	rs148237432		TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:27684212C>T	ENST00000260570.3	-	22	2469	c.2366G>A	c.(2365-2367)cGa>cAa	p.R789Q		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	789					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					CAGTTCCTCTCGGGTCAGCAC	0.567000													17	87					0	0	1	0	0
SPRY3	10251	broad.mit.edu	37	X	155003770	155003770	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chrX:155003770G>A	ENST00000302805.2	+	2	668	c.237G>A	c.(235-237)ctG>ctA	p.L79L		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	79					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCAGCATCTGAGCCAATCTA	0.542000													25	84					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140401654	140401654	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:140401654G>A	ENST00000286349.3	+	2	883	c.692G>A	c.(691-693)cGc>cAc	p.R231H		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	231						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CGCTTTGACCGCTCCTCCGGG	0.617000													13	131					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360256	27360256	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:27360256G>A	ENST00000335524.3	-	3	1467	c.942C>T	c.(940-942)ccC>ccT	p.P314P		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	314										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCTTTTCTCGGGCAGCAGAT	0.667000													20	77					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28354301	28354301	+	Splice_Site	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:28354301T>A	ENST00000373871.3	-	7	738	c.499_splice	c.e7+1	p.Q166_splice	EYA3_ENST00000436342.2_Splice_Site_p.Q40_splice|EYA3_ENST00000545175.1_Splice_Site_p.Q113_splice|EYA3_ENST00000471498.1_5'UTR|EYA3_ENST00000373863.3_Intron|EYA3_ENST00000373864.1_Intron|EYA3_ENST00000540618.1_Intron			Q99504	EYA3_HUMAN	eyes absent homolog 3 (Drosophila)	166					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		CCTATTTACCTTGAATGGGAT	0.368000													10	109					0	0	1	0	0
RANBP10	57610	broad.mit.edu	37	16	67778309	67778309	+	Silent	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:67778309G>A	ENST00000317506.3	-	4	565	c.450C>T	c.(448-450)ttC>ttT	p.F150F	RANBP10_ENST00000602887.1_5'UTR|RANBP10_ENST00000448631.2_Intron|RANBP10_ENST00000602677.1_Silent_p.F150F|RANBP10_ENST00000411657.2_Silent_p.F33F|RANBP10_ENST00000425512.2_Silent_p.F18F|RANBP10_ENST00000536251.1_5'UTR	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	150	B30.2/SPRY.									endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CCGAGGAGCAGAACGAATGCC	0.532000													6	41					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56549545	56549545	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr19:56549545G>A	ENST00000390649.3	+	10	2770	c.2770G>A	c.(2770-2772)Gcc>Acc	p.A924T		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	924						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTCCCAGTGCGCCCTGCAGAA	0.532000													35	94					0	0	1	0	0
PFKFB3	5209	broad.mit.edu	37	10	6257188	6257188	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr10:6257188C>T	ENST00000379775.4	+	3	537	c.207C>T	c.(205-207)ttC>ttT	p.F69F	PFKFB3_ENST00000379789.4_Silent_p.F49F|PFKFB3_ENST00000540253.1_Silent_p.F83F|PFKFB3_ENST00000360521.2_Silent_p.F69F|PFKFB3_ENST00000317350.4_Silent_p.F69F|PFKFB3_ENST00000536985.1_Silent_p.F49F|PFKFB3_ENST00000379785.1_Silent_p.F69F|PFKFB3_ENST00000379782.3_Silent_p.F69F	NM_004566.3	NP_004557.1	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	69	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						CCACAGTGTTCAACGTCGGGG	0.567000													12	61					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18848708	18848708	+	Missense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:18848708T>A	ENST00000446231.2	-	46	7883	c.7471A>T	c.(7471-7473)Agc>Tgc	p.S2491C	SMG1_ENST00000389467.3_Missense_Mutation_p.S2491C			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2491					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						TCATCTAAGCTACCGTCCAAC	0.423000													11	69					0	0	1	0	0
SSTR5	6755	broad.mit.edu	37	16	1129463	1129463	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:1129463G>A	ENST00000293897.4	+	1	683	c.595G>A	c.(595-597)Gcc>Acc	p.A199T	SSTR5_ENST00000397547.2_Missense_Mutation_p.A199T|SSTR5_ENST00000562758.1_Missense_Mutation_p.A199T	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	199					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GCTGTGGGGCGCCGTCTTCAT	0.677000													3	13					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7021701	7021701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:7021701G>A	ENST00000278314.4	-	3	1528	c.1213C>T	c.(1213-1215)Cag>Tag	p.Q405*	ZNF214_ENST00000536068.1_Nonsense_Mutation_p.Q405*	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TGTACTAACTGATGAATTCGA	0.413000													5	120					0	0	1	0	0
RGS7BP	401190	broad.mit.edu	37	5	63803606	63803606	+	Silent	SNP	G	G	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:63803606G>T	ENST00000334025.2	+	2	560	c.234G>T	c.(232-234)tcG>tcT	p.S78S	RGS7BP_ENST00000508162.1_Intron	NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	78					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		GGGATGTCTCGGTCAGCTGCC	0.498000													12	72					2.68362e-12	3.07461e-12	1	1	0
SYF2	25949	broad.mit.edu	37	1	25549805	25549805	+	Silent	SNP	T	T	C			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:25549805T>C	ENST00000236273.4	-	7	709	c.684A>G	c.(682-684)aaA>aaG	p.K228K	SYF2_ENST00000354361.3_Silent_p.K186K	NM_015484.4	NP_056299.1	O95926	SYF2_HUMAN	SYF2 pre-mRNA-splicing factor	228						catalytic step 2 spliceosome				kidney(1)|large_intestine(1)|lung(4)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		CAGCTGTGTATTTCCCATAGA	0.358000													20	200					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182780744	182780744	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:182780744C>G	ENST00000431877.2	+	11	2556	c.2377C>G	c.(2377-2379)Cag>Gag	p.Q793E	SSFA2_ENST00000409136.1_Missense_Mutation_p.Q302E|SSFA2_ENST00000409001.1_Missense_Mutation_p.Q793E|SSFA2_ENST00000428267.2_Missense_Mutation_p.Q640E|SSFA2_ENST00000320370.7_Missense_Mutation_p.Q793E	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	793						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ACATGATGGTCAGTCTTTAGT	0.498000													9	45					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72320109	72320109	+	Missense_Mutation	SNP	C	C	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr15:72320109C>G	ENST00000356056.5	-	4	1433	c.961G>C	c.(961-963)Gag>Cag	p.E321Q	MYO9A_ENST00000564571.1_Missense_Mutation_p.E321Q|MYO9A_ENST00000566885.1_5'UTR|MYO9A_ENST00000424560.1_Missense_Mutation_p.E321Q|MYO9A_ENST00000444904.1_Missense_Mutation_p.E321Q|MYO9A_ENST00000563542.1_5'UTR|RP11-390D11.1_ENST00000568391.1_RNA	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	321	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CTGGACTTCTCCAGTAGATAT	0.299000													20	111					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51484174	51484174	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr6:51484174G>A	ENST00000371117.3	-	67	12205	c.11930C>T	c.(11929-11931)tCc>tTc	p.S3977F	RP3-335N17.2_ENST00000454361.1_RNA|RP3-335N17.2_ENST00000589278.1_RNA	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3977					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GTGCCCATGGGATGTGATGCC	0.557000													21	92					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86590619	86590619	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:86590619G>A	ENST00000370571.2	-	3	1766	c.1400C>T	c.(1399-1401)aCt>aTt	p.T467I	COL24A1_ENST00000436319.1_Missense_Mutation_p.T467I	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	467					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATAAAGCTCAGTTTCATAGCT	0.373000													12	81					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164730803	164730803	+	Missense_Mutation	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:164730803T>A	ENST00000264382.3	-	34	4089	c.4027A>T	c.(4027-4029)Ata>Tta	p.I1343L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1343	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTTTATCTATTGTTATGTTG	0.338000										HNSCC(35;0.089)			22	99					0	0	1	0	0
DCAF4	26094	broad.mit.edu	37	14	73422295	73422295	+	Missense_Mutation	SNP	A	A	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr14:73422295A>G	ENST00000553457.1	+	11	1060	c.770A>G	c.(769-771)aAt>aGt	p.N257S	DCAF4_ENST00000353777.3_Missense_Mutation_p.N187S|DCAF4_ENST00000358377.2_Missense_Mutation_p.N357S|DCAF4_ENST00000555042.1_Missense_Mutation_p.N351S|DCAF4_ENST00000509153.1_Missense_Mutation_p.N297S|DCAF4_ENST00000394234.2_Missense_Mutation_p.N257S			Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	357						CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						CGTTGTGGAAATCAAGGCAAG	0.527000													81	165					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19183871	19183871	+	Missense_Mutation	SNP	G	G	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:19183871G>A	ENST00000375371.3	-	2	458	c.437C>T	c.(436-438)tCt>tTt	p.S146F	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	146					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGTCATGACAGACTCGGAGTT	0.572000													5	64					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27917999	27917999	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr8:27917999C>T	ENST00000413272.2	-	8	1183	c.1041G>A	c.(1039-1041)agG>agA	p.R347R	NUGGC_ENST00000341513.6_Silent_p.R347R	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		GGGCCACGTCCCTACAGAAGC	0.562000											OREG0018675	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	28					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83858433	83858433	+	Silent	SNP	C	C	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:83858433C>T	ENST00000340417.3	-	9	1928	c.1551G>A	c.(1549-1551)tcG>tcA	p.S517S	LIN54_ENST00000506560.1_Silent_p.S428S|LIN54_ENST00000510557.1_Silent_p.S296S|LIN54_ENST00000395282.2_3'UTR|LIN54_ENST00000505397.1_Silent_p.S517S|LIN54_ENST00000395283.2_Silent_p.S428S|LIN54_ENST00000446851.2_Silent_p.S296S|LIN54_ENST00000442461.2_Silent_p.S296S	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	517					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.S517S(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				GCCGACTGGCCGACTCTGATG	0.303000													20	87					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94858013	94858013	+	Splice_Site	SNP	T	T	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr5:94858013T>A	ENST00000358746.2	-	19	2056		c.e19-2			NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37								binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						GCCTGTAAACTAAAATTTAAA	0.338000													3	17					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154842200	154842205	+	In_Frame_Del	DEL	GCTGCT	GCTGCT	-	rs58327065		TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr1:154842200_154842205delGCTGCT	ENST00000271915.3	-	1	551_556	c.236_241delAGCAGC	c.(235-243)cca>c	p.QQP79del		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	79	Poly-Gln.					integral to membrane	calmodulin binding	p.Q80_P81insQQ(2)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GGATGCGGTGgctgctgctgctgctg	0.704													4	4	---	---	---	---					
POMC	5443	broad.mit.edu	37	2	25384456	25384457	+	In_Frame_Ins	INS	-	-	GCCGCTGCT	rs10654394	byFrequency	TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:25384456_25384457insGCCGCTGCT	ENST00000405623.1	-	3	752_753	c.297_298insAGCAGCGGC	c.(295-300)ggcagg>ggAGCAGCGGCcagg	p.99_100GR>GAAAR	POMC_ENST00000380794.1_In_Frame_Ins_p.99_100GR>GAAAR|POMC_ENST00000264708.3_In_Frame_Ins_p.99_100GR>GAAAR|POMC_ENST00000395826.2_In_Frame_Ins_p.99_100GR>GAAAR			P01189	COLI_HUMAN	proopiomelanocortin	99			Missing.		cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TTCTGCCCTGCgccgctgctgc	0.728													7	10	---	---	---	---					
HNRNPA1P57	101060039	broad.mit.edu	37	2	41383697	41383697	+	RNA	DEL	G	G	-	rs111828414		TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr2:41383697delG	ENST00000431359.1	+	0	312																											GGATGCCGCCGAAGAAGCATG	0.373													2	4	---	---	---	---					
PHC3	80012	broad.mit.edu	37	3	169889137	169889138	+	Frame_Shift_Ins	INS	-	-	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr3:169889137_169889138insA	ENST00000497658.1	-	4	454_455	c.437_438insT	c.(436-438)tctfs	p.S146fs	PHC3_ENST00000494943.1_Intron|PHC3_ENST00000474275.1_Intron|PHC3_ENST00000481639.1_Frame_Shift_Ins_p.S142fs|PHC3_ENST00000467570.1_Intron|PHC3_ENST00000495893.1_Intron			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	782	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTAAATCCAGGAAAAAAAAATT	0.337													2	4	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187549909	187549910	+	Frame_Shift_Ins	INS	-	-	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr4:187549909_187549910insA	ENST00000441802.2	-	8	4540_4541	c.4331_4332insT	c.(4330-4332)aaafs	p.K1444fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1444	Cadherin 12.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CTATTACTTTGATGAATACCTG	0.312										HNSCC(5;0.00058)			10	32	---	---	---	---					
ABHD17B	51104	broad.mit.edu	37	9	74489702	74489703	+	Frame_Shift_Ins	INS	-	-	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr9:74489702_74489703insA	ENST00000333421.6	-	2	405_406	c.294_295insT	c.(292-297)cagaaafs	p.QK98fs	ABHD17B_ENST00000377041.2_Frame_Shift_Ins_p.QK98fs	NM_001025780.1	NP_001020951.1			abhydrolase domain containing 17B																		ACAGCATTTCCATGTGAGAAGA	0.366													25	96	---	---	---	---					
WEE1	7465	broad.mit.edu	37	11	9608371	9608371	+	Frame_Shift_Del	DEL	T	T	-			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:9608371delT	ENST00000299613.6	+	10	1868	c.1113delT	c.(1111-1113)aafs	p.N371fs	WEE1_ENST00000450114.2_Frame_Shift_Del_p.N585fs	NM_001143976.1	NP_001137448.1	P30291	WEE1_HUMAN	WEE1 G2 checkpoint kinase	585	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	23				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TAGAATTGAATGCCGAAAAGT	0.343													10	59	---	---	---	---					
KAT5	10524	broad.mit.edu	37	11	65481075	65481077	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:65481075_65481077delGGA	ENST00000341318.4	+	5	786_788	c.552_554delGGA	c.(550-555)gtg>gt	p.VE184del	KAT5_ENST00000352980.4_In_Frame_Del_p.VE99del|KAT5_ENST00000377046.3_In_Frame_Del_p.VE151del|KAT5_ENST00000525204.1_3'UTR|KAT5_ENST00000534650.1_5'UTR|KAT5_ENST00000530446.1_In_Frame_Del_p.VE132del	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	151					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						AACGGAAGGTGGAGGTGGTTTCA	0.542													14	69	---	---	---	---					
PACS1	55690	broad.mit.edu	37	11	65838059	65838061	+	In_Frame_Del	DEL	GCA	GCA	-	rs75352646		TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:65838059_65838061delGCA	ENST00000320580.4	+	1	135_137	c.102_104delGCA	c.(100-105)ccg>cc	p.PQ34del		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	34	Gly-rich.				interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						agccgccgccgcagcagcagcag	0.793													2	4	---	---	---	---					
SRPR	6734	broad.mit.edu	37	11	126134870	126134871	+	Frame_Shift_Ins	INS	-	-	A			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr11:126134870_126134871insA	ENST00000332118.6	-	11	1662_1663	c.1508_1509insT	c.(1507-1509)agafs	p.R503fs	SRPR_ENST00000532259.1_Frame_Shift_Ins_p.R475fs	NM_003139.3	NP_003130.2	P08240	SRPR_HUMAN	signal recognition particle receptor (docking protein)	503					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding			endometrium(7)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)	21	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		CAATGGCTTCCATGGCAATGCC	0.525													10	54	---	---	---	---					
ACTR6	64431	broad.mit.edu	37	12	100613798	100613799	+	Frame_Shift_Ins	INS	-	-	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr12:100613798_100613799insT	ENST00000188312.2	+	10	1700_1701	c.935_936insT	c.(934-936)cttfs	p.L312fs	ACTR6_ENST00000552376.1_Intron|ACTR6_ENST00000551617.1_Intron|ACTR6_ENST00000546902.1_Frame_Shift_Ins_p.L230fs	NM_022496.4	NP_071941.1	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog (yeast)	312						cytoplasm|cytoskeleton				autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14						ATGCAGCCGCATTTTTTTAAGA	0.376													19	68	---	---	---	---					
METRN	79006	broad.mit.edu	37	16	767275	767276	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:767275_767276delGC	ENST00000568223.2	+	4	945_946	c.770_771delGC	c.(769-771)afs	p.S257fs	METRN_ENST00000568415.1_Frame_Shift_Del_p.S124fs	NM_024042.2	NP_076947.1	Q9UJH8	METRN_HUMAN	meteorin, glial cell differentiation regulator	257										skin(1)	1		Hepatocellular(780;0.00335)				ATGGGCTGGAGCCGCTTTGGGG	0.713													3	6	---	---	---	---					
LOC100129781	100129781	broad.mit.edu	37	16	14403341	14403341	+	RNA	DEL	C	C	-			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr16:14403341delC	ENST00000570945.1	+	0	310																											CCTTCTGGGTCCCTGGTAGAT	0.517													2	4	---	---	---	---					
KRTAP1-3	81850	broad.mit.edu	37	17	39190707	39190708	+	Frame_Shift_Ins	INS	-	-	G			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr17:39190707_39190708insG	ENST00000344363.5	-	1	399_400	c.366_367insC	c.(364-369)ccgctgfs	p.L123fs		NM_030966.1	NP_112228.1	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	133						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(6)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACCACACAGCAGGGGGGCAGGC	0.678													12	36	---	---	---	---					
STK4	6789	broad.mit.edu	37	20	43615932	43615933	+	Frame_Shift_Ins	INS	-	-	T			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chr20:43615932_43615933insT	ENST00000372806.3	+	5	615_616	c.520_521insT	c.(520-522)tacfs	p.Y174fs	STK4_ENST00000372801.1_Frame_Shift_Ins_p.Y174fs|STK4_ENST00000499879.2_Intron|STK4_ENST00000396731.4_Frame_Shift_Ins_p.Y174fs	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	174	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				AGCAGGTCAACTTACAGTAAGT	0.297													11	46	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578866	154578866	+	RNA	DEL	T	T	-			TCGA-4P-AA8J-01A-11D-A391-08	TCGA-4P-AA8J-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fe5f8b2-c794-4c93-b2ab-0b544e366f5c	8713028f-5a09-4f4a-8202-cf52b1834ed1	g.chrX:154578866delT	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTCTCTCTGTTTTTTTTTTT	0.418													2	4	---	---	---	---