Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SCMH1	22955	broad.mit.edu	37	1	41514424	41514424	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:41514424G>A	uc001cgo.2	-	11	1525	c.1214C>T	c.(1213-1215)GCT>GTT	p.A405V	SCMH1_uc010ojr.1_Missense_Mutation_p.A247V|SCMH1_uc001cgp.2_Missense_Mutation_p.A344V|SCMH1_uc001cgr.2_Missense_Mutation_p.A344V|SCMH1_uc001cgs.2_Missense_Mutation_p.A415V|SCMH1_uc001cgt.2_Missense_Mutation_p.A344V|SCMH1_uc001cgq.2_Missense_Mutation_p.A358V|SCMH1_uc010ojs.1_RNA	NM_001031694	NP_001026864	Q96GD3	SCMH1_HUMAN	sex comb on midleg 1 isoform 1	405					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				CTGGTGATAAGCACAGTCGAT	0.522		NA											29	60					0	0	0	0
DOCK7	85440	broad.mit.edu	37	1	62921091	62921091	+	Silent	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:62921091A>G	uc001daq.2	-	49	6418	c.6384T>C	c.(6382-6384)GAT>GAC	p.D2128D	DOCK7_uc001dan.2_Silent_p.D1991D|DOCK7_uc001dao.2_Silent_p.D1989D|DOCK7_uc001dap.2_Silent_p.D2108D|DOCK7_uc001dam.2_Silent_p.D1310D	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2139					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CAGTTTAGAGATCCATTTTGC	0.348		NA											12	28					0	0	0	0
SPAG17	200162	broad.mit.edu	37	1	118584559	118584559	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:118584559T>C	uc001ehk.2	-	21	2989	c.2921A>G	c.(2920-2922)AAC>AGC	p.N974S		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	974						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTCTCTGCGTTATCCTTGCC	0.393		NA											79	192					0	0	0	0
TAGLN2	8407	broad.mit.edu	37	1	159890213	159890213	+	Silent	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:159890213G>A	uc001fum.1	-	1	137	c.87C>T	c.(85-87)ATC>ATT	p.I29I	CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Silent_p.I29I|TAGLN2_uc001fuo.1_Silent_p.I29I|TAGLN2_uc010piy.1_Silent_p.I29I	NM_003564	NP_003555	P37802	TAGL2_HUMAN	transgelin 2	29	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTGGATCAGGATCTGCTCCA	0.582		NA											11	46					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171509694	171509694	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:171509694G>T	uc010pmg.1	+	16	3349	c.3083G>T	c.(3082-3084)CGG>CTG	p.R1028L	BAT2L2_uc010pmh.1_Missense_Mutation_p.R5L	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1028	Potential.						protein C-terminus binding				0						AAAGAGGAACGGGAACAGAGG	0.433		NA											11	27					4.69e-08	5.48e-08	1	0
FAM5C	339479	broad.mit.edu	37	1	190067946	190067946	+	Silent	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:190067946C>T	uc001gse.1	-	8	1735	c.1503G>A	c.(1501-1503)CTG>CTA	p.L501L	FAM5C_uc010pot.1_Silent_p.L399L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	501						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CCGTTTTCTGCAGCAGATATT	0.502		NA											27	96					0	0	0	0
FAM5C	339479	broad.mit.edu	37	1	190067951	190067951	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:190067951G>T	uc001gse.1	-	8	1730	c.1498C>A	c.(1498-1500)CTG>ATG	p.L500M	FAM5C_uc010pot.1_Missense_Mutation_p.L398M	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	500						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTCTGCAGCAGATATTTCATC	0.493		NA											27	102					7.42e-09	8.79e-09	1	0
OR2T3	343173	broad.mit.edu	37	1	248637082	248637083	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:248637082_248637083GG>TT	uc001iel.1	+	1	431_432	c.431_432GG>TT	c.(430-432)AGG>ATT	p.R144I		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	144	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGAACCAGAGGGTGTGCCAGC	0.55		NA											6	26					0	0	0	0
SAMD8	142891	broad.mit.edu	37	10	76910800	76910800	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr10:76910800A>G	uc001jwx.1	+	2	617	c.514A>G	c.(514-516)ATA>GTA	p.I172V	SAMD8_uc001jwy.1_Missense_Mutation_p.I172V	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	172	Helical; (Potential).				sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CATTATGGTTATAGTCCATGA	0.368		NA											3	31					0	0	0	0
RAB11FIP2	22841	broad.mit.edu	37	10	119798612	119798612	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr10:119798612C>T	uc001ldj.1	-	3	1576	c.1136G>A	c.(1135-1137)GGA>GAA	p.G379E	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.G379E	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	379					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GCTATCAGATCCCCCATTGTT	0.353		NA											10	73					0	0	0	0
FAM53B	9679	broad.mit.edu	37	10	126370453	126370453	+	Missense_Mutation	SNP	G	G	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr10:126370453G>C	uc001lhv.1	-	4	1152	c.629C>G	c.(628-630)ACC>AGC	p.T210S	FAM53B_uc001lhu.1_Missense_Mutation_p.T210S|FAM53B_uc001lhw.2_Missense_Mutation_p.T210S	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	210										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		AGGGCTCCAGGTGTCACCTGC	0.642		NA											2	9					0	0	0	0
FOLH1	2346	broad.mit.edu	37	11	49227672	49227672	+	Silent	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:49227672A>G	uc001ngy.2	-	2	432	c.171T>C	c.(169-171)AAT>AAC	p.N57N	FOLH1_uc001ngz.2_Silent_p.N57N|FOLH1_uc009yly.2_Silent_p.N42N|FOLH1_uc009ylz.2_Silent_p.N42N|FOLH1_uc009yma.2_5'UTR|FOLH1_uc001nha.2_Silent_p.N42N	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	57	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ATGCTTTCATATTATGCTTTG	0.323		NA											14	26					0	0	0	0
DAGLA	747	broad.mit.edu	37	11	61511763	61511763	+	Silent	SNP	C	C	G	rs145101853		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:61511763C>G	uc001nsa.2	+	20	3042	c.2931C>G	c.(2929-2931)GCC>GCG	p.A977A		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	977	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GGCTCTTTGCCGGCTCAGCCG	0.677		NA											21	55					0	0	0	0
B3GNT1	11041	broad.mit.edu	37	11	66113556	66113556	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:66113556C>G	uc001ohr.2	-	2	1357	c.1212G>C	c.(1210-1212)TTG>TTC	p.L404F	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	404	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						ACTTGGCCTTCAACTCCTGTT	0.512		NA											24	110					0	0	0	0
FAM55B	120406	broad.mit.edu	37	11	114568901	114568901	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:114568901G>T	uc009yyy.2	+	3	365	c.267G>T	c.(265-267)GAG>GAT	p.E89D		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	89						integral to membrane				ovary(1)	1						ACATTATGGAGAAACTAGACC	0.458		NA											15	23					5.35e-07	6.14e-07	1	0
VWA5A	4013	broad.mit.edu	37	11	124007741	124007741	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:124007741G>T	uc001pzu.2	+	15	1854	c.1645G>T	c.(1645-1647)GCT>TCT	p.A549S	VWA5A_uc001pzt.2_Missense_Mutation_p.A549S	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	549										upper_aerodigestive_tract(1)|ovary(1)	2						TCACCGCCTTGCTGCCAAGTC	0.453		NA											23	30					2.45e-14	3.02e-14	1	0
CD163	9332	broad.mit.edu	37	12	7639150	7639150	+	Silent	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:7639150G>A	uc001qsz.3	-	10	2531	c.2403C>T	c.(2401-2403)CAC>CAT	p.H801H	CD163_uc001qta.3_Silent_p.H801H|CD163_uc009zfw.2_Silent_p.H834H	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	801	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GCCCCCAGCCGTGTGAATGGC	0.483		NA											46	114					0	0	0	0
TMEM117	84216	broad.mit.edu	37	12	44605082	44605082	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:44605082A>G	uc001rod.2	+	5	586	c.520A>G	c.(520-522)ATG>GTG	p.M174V	TMEM117_uc001roe.2_Missense_Mutation_p.M70V|TMEM117_uc009zkc.2_Missense_Mutation_p.M174V	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	174	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GGTCACTGATATGATGCTTCA	0.353		NA											14	49					0	0	0	0
ERBB3	2065	broad.mit.edu	37	12	56481413	56481413	+	Missense_Mutation	SNP	A	A	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:56481413A>T	uc001sjh.2	+	5	793	c.600A>T	c.(598-600)GAA>GAT	p.E200D	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.E141D|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	200	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTGGATCAGAAGACTGCCAGA	0.552		NA											20	42					0	0	0	0
MED13L	23389	broad.mit.edu	37	12	116421091	116421091	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:116421091T>C	uc001tvw.2	-	21	4841	c.4786A>G	c.(4786-4788)ATT>GTT	p.I1596V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1596	Ser-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ATCTGGCTAATACCAGGAGCA	0.512		NA											22	37					0	0	0	0
GCN1L1	10985	broad.mit.edu	37	12	120584869	120584869	+	Missense_Mutation	SNP	A	A	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:120584869A>C	uc001txo.2	-	38	4947	c.4934T>G	c.(4933-4935)CTG>CGG	p.L1645R		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1645	HEAT 11.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGGTCTGTCAGGGAGTACAT	0.557		NA											9	15					0	0	0	0
KNTC1	9735	broad.mit.edu	37	12	123095404	123095404	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:123095404A>G	uc001ucv.2	+	53	5742	c.5579A>G	c.(5578-5580)TAT>TGT	p.Y1860C	KNTC1_uc010taf.1_Missense_Mutation_p.Y785C	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1860					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CCAATTGATTATAGTTCAAGA	0.328		NA											12	24					0	0	0	0
MTUS2	23281	broad.mit.edu	37	13	29600957	29600957	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:29600957G>A	uc001usl.3	+	1	2210	c.2152G>A	c.(2152-2154)GTC>ATC	p.V718I		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	708	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GAAGCCAAGGGTCTTCAGTTC	0.493		NA											14	29					0	0	0	0
SPG20	23111	broad.mit.edu	37	13	36909740	36909740	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:36909740C>A	uc001uvn.2	-	3	498	c.228G>T	c.(226-228)CAG>CAT	p.Q76H	SPG20_uc010ten.1_Missense_Mutation_p.Q76H|SPG20_uc001uvm.2_Missense_Mutation_p.Q76H|SPG20_uc001uvo.2_Missense_Mutation_p.Q76H|SPG20_uc001uvq.2_Missense_Mutation_p.Q76H|SPG20_uc001uvp.2_Missense_Mutation_p.Q76H	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	76	MIT.				cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		TCTGTTGCATCTGTCTAGCAG	0.453		NA											26	27					9.58e-11	1.16e-10	1	0
PCDH8	5100	broad.mit.edu	37	13	53421763	53421763	+	Missense_Mutation	SNP	G	G	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:53421763G>C	uc001vhi.2	-	1	1012	c.809C>G	c.(808-810)GCA>GGA	p.A270G	PCDH8_uc001vhj.2_Missense_Mutation_p.A270G	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	270	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GGGGTCGGCTGCGTCCAGGTC	0.711		NA											2	1					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328847	88328847	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:88328847G>T	uc001vln.2	+	2	1423	c.1204G>T	c.(1204-1206)GCT>TCT	p.A402S	SLITRK5_uc010tic.1_Missense_Mutation_p.A161S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	402	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CGAGAGCATCGCTGAACTGCA	0.567		NA											17	19					2.35e-11	2.86e-11	1	0
COQ6	51004	broad.mit.edu	37	14	74428218	74428218	+	Missense_Mutation	SNP	T	T	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr14:74428218T>A	uc001xph.2	+	10	1235	c.1155T>A	c.(1153-1155)GAT>GAA	p.D385E	ENTPD5_uc001xpi.2_Intron|COQ6_uc001xpe.2_Missense_Mutation_p.D310E|COQ6_uc001xpf.2_Missense_Mutation_p.D310E|COQ6_uc010tuk.1_Missense_Mutation_p.D360E|COQ6_uc001xpg.2_Missense_Mutation_p.D385E	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	385					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		GCTTTGGGGATATCTCCAGCT	0.512		NA											10	27					0	0	0	0
TRPM7	54822	broad.mit.edu	37	15	50935734	50935734	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:50935734T>C	uc001zyt.3	-	5	602	c.338A>G	c.(337-339)TAT>TGT	p.Y113C	TRPM7_uc010bew.1_Missense_Mutation_p.Y113C	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	113	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTTGGTGTCATATGATAGCCT	0.338		NA											16	40					0	0	0	0
IQCH	64799	broad.mit.edu	37	15	67786666	67786666	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:67786666A>G	uc002aqo.1	+	20	2979	c.2932A>G	c.(2932-2934)ATA>GTA	p.I978V	IQCH_uc002aqq.1_Missense_Mutation_p.I635V|IQCH_uc002aqp.1_Missense_Mutation_p.N618S|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	978										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CCATCAAGAAATATCAGCACC	0.398		NA											5	21					0	0	0	0
MESDC2	23184	broad.mit.edu	37	15	81282115	81282115	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:81282115C>T	uc002bfy.1	-	1	91	c.18G>A	c.(16-18)TGG>TGA	p.W6*	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	6	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						CCTTGCGCGCCCACCTGGAAG	0.642		NA											8	11					0	0	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92671678	92671678	+	Missense_Mutation	SNP	A	A	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:92671678A>T	uc002bqx.2	+	7	1672	c.1471A>T	c.(1471-1473)ATC>TTC	p.I491F	SLCO3A1_uc002bqy.2_Missense_Mutation_p.I491F|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Missense_Mutation_p.I433F	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	491	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GGCAGATGGCATCACCTACCT	0.463		NA											19	45					0	0	0	0
ST8SIA2	8128	broad.mit.edu	37	15	93007600	93007600	+	Silent	SNP	C	C	T	rs113311093		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:93007600C>T	uc002bra.2	+	6	1268	c.1113C>T	c.(1111-1113)TGC>TGT	p.C371C	ST8SIA2_uc002brb.2_Silent_p.C350C	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	371	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TCGGCCAGTGCGATGGGGCCA	0.597		NA											27	57					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	21078616	21078616	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:21078616A>G	uc010vbe.1	-	24	3506	c.3506T>C	c.(3505-3507)CTA>CCA	p.L1169P		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1169	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGGGAAGAATAGTCTCTTCTT	0.438		NA											21	13					0	0	0	0
CHD9	80205	broad.mit.edu	37	16	53358379	53358379	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:53358379A>G	uc002ehb.2	+	38	8430	c.8266A>G	c.(8266-8268)AGG>GGG	p.R2756G	CHD9_uc002egy.2_Missense_Mutation_p.R2740G|CHD9_uc002ehc.2_Missense_Mutation_p.R2741G|CHD9_uc002ehf.2_Missense_Mutation_p.R1854G|CHD9_uc010cbw.2_Missense_Mutation_p.R822G	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2756					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AAAAACAGAAAGGACAGAGAG	0.463		NA											19	24					0	0	0	0
ZZEF1	23140	broad.mit.edu	37	17	3921231	3921231	+	Missense_Mutation	SNP	T	T	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:3921231T>A	uc002fxe.2	-	47	7604	c.7540A>T	c.(7540-7542)ATA>TTA	p.I2514L	ZZEF1_uc002fxg.1_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2514							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGGGACCGTATCCTTTCATCT	0.507		NA											9	38					0	0	0	0
USP6	9098	broad.mit.edu	37	17	5042664	5042664	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:5042664G>A	uc002gau.1	+	22	3423	c.1193G>A	c.(1192-1194)CGG>CAG	p.R398Q	USP6_uc002gav.1_Missense_Mutation_p.R398Q|USP6_uc010ckz.1_Missense_Mutation_p.R81Q|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	398					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						CAGTTCCAGCGGCCCATTTGC	0.657		NA	T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								7	24					0	0	0	0
ZNF286A	57335	broad.mit.edu	37	17	15620349	15620349	+	Silent	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:15620349C>T	uc010cot.2	+	6	1707	c.1311C>T	c.(1309-1311)CCC>CCT	p.P437P	ZNF286A_uc002goz.3_Silent_p.P325P|ZNF286A_uc010vwa.1_Silent_p.P437P|ZNF286A_uc002gpa.2_Silent_p.P437P	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GAGAGAAACCCTATGAGTGTA	0.388		NA											14	23					0	0	0	0
GPR179	440435	broad.mit.edu	37	17	36485312	36485312	+	Silent	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:36485312C>A	uc002hpz.2	-	11	4161	c.4140G>T	c.(4138-4140)CCG>CCT	p.P1380P		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1380	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCCAGGGACACGGCTCTGCCT	0.597		NA											42	73					2.36e-20	2.95e-20	1	0
MED1	5469	broad.mit.edu	37	17	37564173	37564173	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:37564173G>A	uc002hrv.3	-	17	4513	c.4301C>T	c.(4300-4302)CCA>CTA	p.P1434L	MED1_uc010wee.1_Missense_Mutation_p.P1262L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1434	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		ACTGATGAGTGGAGAGCCATA	0.488		NA								HNSCC(31;0.082)			19	41					0	0	0	0
CCR7	1236	broad.mit.edu	37	17	38711204	38711204	+	Silent	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:38711204G>A	uc002huw.2	-	3	990	c.927C>T	c.(925-927)GAC>GAT	p.D309D		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	309	Extracellular (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				TGTAGGTGACGTCGTAGGCGA	0.567		NA											9	38					0	0	0	0
TANC2	26115	broad.mit.edu	37	17	61432352	61432352	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:61432352A>G	uc002jal.3	+	12	1984	c.1961A>G	c.(1960-1962)TAT>TGT	p.Y654C	TANC2_uc010wpe.1_Missense_Mutation_p.Y564C|TANC2_uc002jam.1_Missense_Mutation_p.Y21C	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	654							binding			ovary(2)	2						CAAGGGTCCTATCTATATCTG	0.388		NA											38	84					0	0	0	0
ZNF521	25925	broad.mit.edu	37	18	22807417	22807417	+	Missense_Mutation	SNP	G	G	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:22807417G>C	uc002kvk.2	-	4	712	c.465C>G	c.(463-465)TTC>TTG	p.F155L	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.F155L|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	155	C2H2-type 3.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GCTTGTGTTTGAACAGCCTAC	0.498		NA	T	PAX5	ALL								14	64					0	0	0	0
RIT2	6014	broad.mit.edu	37	18	40695399	40695399	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:40695399C>T	uc002lav.2	-	1	259	c.86G>A	c.(85-87)GGG>GAG	p.G29E	RIT2_uc010dnf.2_Missense_Mutation_p.G29E	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	29	GTP (By similarity).				nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						ACCAACTCCCCCTGCTCCCAG	0.512		NA											20	189					0	0	0	0
SYT4	6860	broad.mit.edu	37	18	40850388	40850388	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:40850388C>G	uc002law.2	-	4	1565	c.1196G>C	c.(1195-1197)GGA>GCA	p.G399A	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.G381A|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	399	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TCCACCAGTTCCTTCTGCTGC	0.493		NA											34	208					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50432611	50432611	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:50432611C>A	uc002lfe.1	+	3	1197	c.610C>A	c.(610-612)CCG>ACG	p.P204T	DCC_uc010xdr.1_Missense_Mutation_p.P52T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	204	Extracellular (Potential).|Ig-like C2-type 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCGACTCCAACCGGGGGACAT	0.502		NA											7	24					0.000442599	0.000490081	1	0
ZADH2	284273	broad.mit.edu	37	18	72914167	72914167	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:72914167G>T	uc002llx.2	-	2	606	c.338C>A	c.(337-339)GCC>GAC	p.A113D	ZADH2_uc010dqv.2_5'UTR	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	113						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TGTGTATCTGGCACTAGCAGA	0.542		NA											15	48					3.27e-08	3.85e-08	1	0
ZNF99	7652	broad.mit.edu	37	19	22941472	22941472	+	Silent	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:22941472A>G	uc010xrh.1	-	5	966	c.966T>C	c.(964-966)ACT>ACC	p.T322T		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CCTTATGTACAGTAAGTTTTG	0.363		NA											15	25					0	0	0	0
ZNF383	163087	broad.mit.edu	37	19	37733572	37733572	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:37733572C>T	uc002oft.1	+	8	1014	c.434C>T	c.(433-435)CCT>CTT	p.P145L	ZNF383_uc002ofs.1_Missense_Mutation_p.P80L|ZNF383_uc002ofu.1_Missense_Mutation_p.P145L	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATATTCACTCCTGAATACATG	0.368		NA											30	54					0	0	0	0
RASGRP4	115727	broad.mit.edu	37	19	38903847	38903847	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:38903847C>T	uc002oir.2	-	11	1616	c.1402G>A	c.(1402-1404)GAG>AAG	p.E468K	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Missense_Mutation_p.E399K|RASGRP4_uc010xub.1_Missense_Mutation_p.E434K|RASGRP4_uc010xuc.1_Missense_Mutation_p.E376K|RASGRP4_uc010xud.1_Missense_Mutation_p.E371K|RASGRP4_uc010xue.1_Missense_Mutation_p.E279K|RASGRP4_uc010egb.2_Missense_Mutation_p.E454K	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	468	EF-hand.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			ACCAGCTGCTCCACATGCCGA	0.667		NA											7	13					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627		NA											7	16					0	0	0	0
ZNF404	342908	broad.mit.edu	37	19	44377455	44377455	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:44377455C>T	uc002oxs.3	-	2	911	c.902G>A	c.(901-903)TGT>TAT	p.C301Y		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	304	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GGCCTTTTCACATTGTTCACA	0.368		NA											5	21					0	0	0	0
ZC3H4	23211	broad.mit.edu	37	19	47584838	47584838	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:47584838T>C	uc002pga.3	-	11	1410	c.1372A>G	c.(1372-1374)ATC>GTC	p.I458V	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	458	C3H1-type 3.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCACCATTGATGCAGTTCCCA	0.547		NA											16	26					0	0	0	0
MED25	81857	broad.mit.edu	37	19	50334077	50334077	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:50334077G>T	uc002ppw.1	+	9	1087	c.1034G>T	c.(1033-1035)AGT>ATT	p.S345I	MED25_uc010ybe.1_Missense_Mutation_p.S132I|MED25_uc002ppx.1_Missense_Mutation_p.S126I	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	345	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		TCCCAGCCCAGTCTGGTCTCC	0.726		NA											21	28					7.42e-09	8.79e-09	1	0
ZNF611	81856	broad.mit.edu	37	19	53209236	53209236	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:53209236G>A	uc002pzz.2	-	7	1389	c.1072C>T	c.(1072-1074)CTT>TTT	p.L358F	ZNF611_uc010eqc.2_Missense_Mutation_p.L288F|ZNF611_uc010ydo.1_Missense_Mutation_p.L288F|ZNF611_uc010ydr.1_Missense_Mutation_p.L289F|ZNF611_uc010ydp.1_Missense_Mutation_p.L358F|ZNF611_uc010ydq.1_Missense_Mutation_p.L358F|ZNF611_uc002qaa.3_Missense_Mutation_p.L288F	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	358	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TGATGTGAAAGTTGTGATTGT	0.343		NA											8	48					0	0	0	0
POMC	5443	broad.mit.edu	37	2	25387568	25387568	+	Missense_Mutation	SNP	C	C	A	rs143923583	byFrequency	TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:25387568C>A	uc002rfy.1	-	3	337	c.74G>T	c.(73-75)CGT>CTT	p.R25L	POMC_uc002rfz.1_Missense_Mutation_p.R25L|POMC_uc002rga.1_Missense_Mutation_p.R25L	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	25					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	GCACCAGCCACGCACTTCCAT	0.612		NA											21	41					1.02e-10	1.23e-10	1	0
B3GNT2	10678	broad.mit.edu	37	2	62450518	62450518	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:62450518C>G	uc002sbs.2	+	2	1401	c.1163C>G	c.(1162-1164)TCT>TGT	p.S388C		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	388	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GATATTTGGTCTCAGTTGCAG	0.323		NA											6	28					0	0	0	0
SLC35F5	80255	broad.mit.edu	37	2	114476737	114476737	+	Missense_Mutation	SNP	A	A	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:114476737A>T	uc002tku.1	-	14	1914	c.1490T>A	c.(1489-1491)ATT>AAT	p.I497N	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	497					transport	integral to membrane					0						TTACCTCTGAATTCGATGTTT	0.333		NA											6	30					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	140990803	140990803	+	Missense_Mutation	SNP	T	T	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:140990803T>A	uc002tvj.1	-	91	14724	c.13752A>T	c.(13750-13752)GAA>GAT	p.E4584D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4584	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGAAGCAGTTCTTTCCTTT	0.328		NA								TSP Lung(27;0.18)			7	28					0	0	0	0
RIF1	55183	broad.mit.edu	37	2	152276855	152276855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:152276855C>T	uc002txm.2	+	7	785	c.655C>T	c.(655-657)CAA>TAA	p.Q219*	RIF1_uc002txl.2_Nonsense_Mutation_p.Q219*|RIF1_uc010fnv.1_Nonsense_Mutation_p.Q183*|RIF1_uc002txn.2_Nonsense_Mutation_p.Q219*|RIF1_uc002txo.2_Nonsense_Mutation_p.Q219*|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	219					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TCAGAAACAGCAAGAAATAGC	0.413		NA											4	30					0	0	0	0
GALNT13	114805	broad.mit.edu	37	2	155252510	155252510	+	Silent	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:155252510C>T	uc002tyr.3	+	10	1731	c.1164C>T	c.(1162-1164)GTC>GTT	p.V388V	GALNT13_uc002tyt.3_Silent_p.V388V|GALNT13_uc010foc.1_Silent_p.V207V|GALNT13_uc010fod.2_Silent_p.V141V	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	388	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CAGGTGTTGTCAAAGTGGATT	0.353		NA											8	12					0	0	0	0
ARMC9	80210	broad.mit.edu	37	2	232079577	232079577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:232079577C>T	uc002vrq.3	+	4	323	c.211C>T	c.(211-213)CAG>TAG	p.Q71*	ARMC9_uc002vrp.3_Nonsense_Mutation_p.Q71*	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	71							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CAACGGAGACCAGAAGGTGTT	0.463		NA											11	28					0	0	0	0
TTC3	7267	broad.mit.edu	37	21	38567994	38567994	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr21:38567994C>T	uc002yvz.2	+	42	5341	c.5236C>T	c.(5236-5238)CCT>TCT	p.P1746S	TTC3_uc002ywa.2_Missense_Mutation_p.P1746S|TTC3_uc002ywb.2_Missense_Mutation_p.P1746S|TTC3_uc010gnf.2_Missense_Mutation_p.P1511S|TTC3_uc002ywc.2_Missense_Mutation_p.P1436S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1746					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CGAGTTACTCCCTGAGTCTTC	0.532		NA											39	145					0	0	0	0
UMODL1	89766	broad.mit.edu	37	21	43547902	43547902	+	Silent	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr21:43547902C>A	uc002zaf.1	+	20	3651	c.3651C>A	c.(3649-3651)CTC>CTA	p.L1217L	UMODL1_uc002zad.1_Silent_p.L1145L|UMODL1_uc002zae.1_Silent_p.L1273L|UMODL1_uc002zag.1_Silent_p.L1345L|UMODL1_uc002zal.1_Silent_p.L167L|UMODL1_uc010gpa.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1217	Extracellular (Potential).|ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						ACTGCAAACTCCGCGTCTGCA	0.468		NA											7	33					0.00198382	0.00213927	1	0
POTEH	23784	broad.mit.edu	37	22	16267045	16267045	+	Silent	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr22:16267045T>C	uc010gqp.2	-	9	1456	c.1404A>G	c.(1402-1404)GAA>GAG	p.E468E	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.E187E|POTEH_uc002zlj.1_Silent_p.E303E	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	468										skin(1)	1						TAGTCAGGTTTTCTGGGAATC	0.403		NA											42	197					0	0	0	0
TOM1	10043	broad.mit.edu	37	22	35726367	35726367	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr22:35726367C>T	uc003ann.2	+	8	918	c.793C>T	c.(793-795)CAG>TAG	p.Q265*	TOM1_uc011ami.1_Nonsense_Mutation_p.Q232*|TOM1_uc011amj.1_Nonsense_Mutation_p.Q108*|TOM1_uc003ans.2_Nonsense_Mutation_p.Q108*|TOM1_uc011amk.1_Nonsense_Mutation_p.Q227*|TOM1_uc003anp.2_Nonsense_Mutation_p.Q265*|TOM1_uc011aml.1_Nonsense_Mutation_p.Q220*|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Nonsense_Mutation_p.Q259*|TOM1_uc003anr.2_Nonsense_Mutation_p.Q108*	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	265	GAT.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CCGAGCCATGCAGCAGCGGGT	0.517		NA											32	67					0	0	0	0
LOC401052	401052	broad.mit.edu	37	3	10049172	10049172	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr3:10049172C>G	uc003bur.1	-	4	827	c.213G>C	c.(211-213)CAG>CAC	p.Q71H	CIDEC_uc003bto.2_Intron	NM_001008737	NP_001008737	B3KMQ7	B3KMQ7_HUMAN	hypothetical protein LOC401052	71											0						ATTGGCCTTTCTGCTTCGATG	0.582		NA											37	54					0	0	0	0
PLCL2	23228	broad.mit.edu	37	3	17052602	17052602	+	Missense_Mutation	SNP	A	A	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr3:17052602A>C	uc011awc.1	+	5	1845	c.1740A>C	c.(1738-1740)GAA>GAC	p.E580D	PLCL2_uc011awd.1_Missense_Mutation_p.E462D	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	588					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						ACGAAGATGAAGGAGCAGAAA	0.433		NA											10	9					0	0	0	0
UPK1B	7348	broad.mit.edu	37	3	118905597	118905597	+	Missense_Mutation	SNP	A	A	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr3:118905597A>T	uc003ecc.2	+	2	98	c.9A>T	c.(7-9)AAA>AAT	p.K3N	UPK1B_uc011bix.1_Intron|UPK1B_uc003ecd.2_Missense_Mutation_p.K3N	NM_006952	NP_008883	O75841	UPK1B_HUMAN	uroplakin 1B	3	Cytoplasmic (Potential).				epithelial cell differentiation	integral to membrane	structural molecule activity				0				GBM - Glioblastoma multiforme(114;0.222)		AGATGGCCAAAGACAACTCAA	0.418		NA											25	25					0	0	0	0
ZNF721	170960	broad.mit.edu	37	4	436033	436033	+	Silent	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:436033G>A	uc003gag.2	-	3	2914	c.2223C>T	c.(2221-2223)AAC>AAT	p.N741N	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Silent_p.N773N|ZNF721_uc010ibe.2_Silent_p.N729N	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	741						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCTTATATTCGTTCAGGTTTG	0.388		NA											3	11					0	0	0	0
DDX60	55601	broad.mit.edu	37	4	169188752	169188752	+	Missense_Mutation	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:169188752G>A	uc003irp.2	-	22	3312	c.3020C>T	c.(3019-3021)GCT>GTT	p.A1007V		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1007							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGTTAGTGCAGCACATGGGTG	0.284		NA											11	38					0	0	0	0
C4orf41	60684	broad.mit.edu	37	4	184626159	184626159	+	Silent	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:184626159C>A	uc003ivx.2	+	27	3167	c.2991C>A	c.(2989-2991)ATC>ATA	p.I997I	C4orf41_uc003ivw.2_Silent_p.I997I|C4orf41_uc010isc.2_Silent_p.I341I|C4orf41_uc003ivy.2_Silent_p.I603I	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	997											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		ATATCCCCATCATCACAACTG	0.358		NA											35	85					2.95e-19	3.68e-19	1	0
SORBS2	8470	broad.mit.edu	37	4	186545478	186545478	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:186545478C>A	uc003iyl.2	-	13	1951	c.1093G>T	c.(1093-1095)GCA>TCA	p.A365S	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.A465S|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.A269S|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.A479S|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	365						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CAGATTTCTGCGTTTTGCCGG	0.522		NA											19	52					2.38e-13	2.9e-13	1	0
KLKB1	3818	broad.mit.edu	37	4	187179174	187179174	+	Splice_Site	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:187179174G>T	uc003iyy.2	+	15	1797	c.1726_splice	c.e15-1	p.G576_splice	KLKB1_uc011clc.1_Splice_Site_p.G374_splice|KLKB1_uc011cld.1_Splice_Site_p.G491_splice	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor						blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CTGTGACTCAGGGAGATTCAG	0.478		NA											16	43					2e-07	2.3e-07	1	0
IRX1	79192	broad.mit.edu	37	5	3601102	3601102	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:3601102T>C	uc003jde.2	+	4	1443	c.1391T>C	c.(1390-1392)CTG>CCG	p.L464P		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	464						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TGCAGCTCTCTGGCCCCGCAG	0.662		NA											14	53					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23522415	23522415	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:23522415C>G	uc003jgo.2	+	7	693	c.511C>G	c.(511-513)CTC>GTC	p.L171V		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	171					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CAACCTAGAACTCAGGAAGAA	0.433		NA								HNSCC(3;0.000094)			26	93					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24505331	24505331	+	Missense_Mutation	SNP	A	A	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:24505331A>T	uc003jgr.1	-	8	1615	c.1283T>A	c.(1282-1284)CTT>CAT	p.L428H	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	428	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GATTCTGTCAAGGTCAGTATG	0.358		NA								HNSCC(23;0.051)			17	35					0	0	0	0
PRKAA1	5562	broad.mit.edu	37	5	40767661	40767661	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:40767661T>C	uc003jmc.2	-	6	734	c.728A>G	c.(727-729)TAT>TGT	p.Y243C	PRKAA1_uc003jmb.2_Missense_Mutation_p.Y258C	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	243	Protein kinase.				activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TTGAGGGGTATAGAAGATCCC	0.388		NA											15	79					0	0	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182317	140182317	+	Missense_Mutation	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:140182317C>A	uc003lhf.2	+	1	1535	c.1535C>A	c.(1534-1536)GCG>GAG	p.A512E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A512E	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	512	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGTACACGCGGAGAGCGGC	0.706		NA											42	41					2.25e-16	2.79e-16	1	0
ZNF354C	30832	broad.mit.edu	37	5	178505981	178505981	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:178505981T>C	uc003mju.2	+	5	663	c.548T>C	c.(547-549)ATA>ACA	p.I183T		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		AGTGTTCCTATAGAAAGGATA	0.358		NA											18	19					0	0	0	0
FAM83B	222584	broad.mit.edu	37	6	54804723	54804723	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr6:54804723C>G	uc003pck.2	+	5	1070	c.954C>G	c.(952-954)AGC>AGG	p.S318R		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	318										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CTGTTTCCAGCCAGAGAAACC	0.388		NA											19	47					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48318540	48318540	+	Silent	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:48318540A>G	uc003toq.2	+	18	7774	c.7749A>G	c.(7747-7749)ACA>ACG	p.T2583T	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2583					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATCATTTCACATTTGAAAAGA	0.308		NA											29	45					0	0	0	0
PARP12	64761	broad.mit.edu	37	7	139737556	139737556	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:139737556T>C	uc003vvl.1	-	7	2157	c.1283A>G	c.(1282-1284)AAG>AGG	p.K428R	PARP12_uc003vvk.1_Missense_Mutation_p.K214R|PARP12_uc010lnf.1_Intron	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	428	WWE 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					GGCCTGGAACTTCAAGGTGGC	0.602		NA											11	26					0	0	0	0
OR2A2	442361	broad.mit.edu	37	7	143806912	143806912	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:143806912G>T	uc011ktz.1	+	1	237	c.237G>T	c.(235-237)AAG>AAT	p.K79N		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					ATGTTCCCAAGATGTTGGCAA	0.433		NA											27	152					4.72e-08	5.48e-08	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146825855	146825855	+	Missense_Mutation	SNP	T	T	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:146825855T>G	uc003weu.1	+	7	1526	c.1010T>G	c.(1009-1011)ATG>AGG	p.M337R		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	337	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGGCTGCATGGAAAGCATC	0.408		NA								HNSCC(39;0.1)			40	70					0	0	0	0
SMARCD3	6604	broad.mit.edu	37	7	150936506	150936506	+	Silent	SNP	G	G	A	rs139287814		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:150936506G>A	uc003wjs.2	-	12	1475	c.1374C>T	c.(1372-1374)GCC>GCT	p.A458A	SMARCD3_uc003wjt.2_Silent_p.A445A|SMARCD3_uc003wju.2_Silent_p.A445A	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	458					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCGACTGACGGCCTCCTGGG	0.612		NA											12	34					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154585880	154585880	+	Missense_Mutation	SNP	C	C	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:154585880C>G	uc003wlk.2	+	11	1357	c.1228C>G	c.(1228-1230)CTC>GTC	p.L410V	DPP6_uc003wli.2_Missense_Mutation_p.L346V|DPP6_uc003wlm.2_Missense_Mutation_p.L348V|DPP6_uc011kvq.1_Missense_Mutation_p.L303V	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	410	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CATCCTCACCCTCTGCGACGC	0.657		NA											4	10					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	2832027	2832027	+	Missense_Mutation	SNP	T	T	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:2832027T>C	uc011kwk.1	-	56	9079	c.8689A>G	c.(8689-8691)ACG>GCG	p.T2897A	CSMD1_uc011kwj.1_Missense_Mutation_p.T2226A|CSMD1_uc010lrg.2_Missense_Mutation_p.T907A	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2897	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACACTCTCGTGTCGTTGCCT	0.572		NA											5	8					0	0	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409370	59409370	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:59409370G>T	uc003xtm.3	-	3	764	c.701C>A	c.(700-702)GCC>GAC	p.A234D		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	234					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TTTCTCCCGGGCATTGTGCGC	0.488		NA							Neonatal_Giant_Cell_Hepatitis				20	76					1.16e-05	1.32e-05	1	0
TRHR	7201	broad.mit.edu	37	8	110131301	110131301	+	Missense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:110131301G>T	uc003ymz.3	+	2	830	c.814G>T	c.(814-816)GTA>TTA	p.V272L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	272	Helical; Name=6; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity	p.V272A(1)		skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GGCAGTGGTTGTAATTCTGTT	0.413		NA											152	134					3.55e-78	4.48e-78	1	0
KDM4C	23081	broad.mit.edu	37	9	6986506	6986506	+	Missense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr9:6986506C>T	uc003zkh.2	+	11	2097	c.1517C>T	c.(1516-1518)TCA>TTA	p.S506L	KDM4C_uc010mhu.2_Missense_Mutation_p.S528L|KDM4C_uc011lmi.1_Missense_Mutation_p.S506L|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.S506L|KDM4C_uc011lmk.1_Missense_Mutation_p.S325L|KDM4C_uc011lml.1_Missense_Mutation_p.S193L	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	506					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TCCGAGCTTTCATGGCCAAAG	0.478		NA											17	24					0	0	0	0
VPS13A	23230	broad.mit.edu	37	9	79898351	79898351	+	Missense_Mutation	SNP	G	G	C			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr9:79898351G>C	uc004akr.2	+	30	3459	c.3199G>C	c.(3199-3201)GAT>CAT	p.D1067H	VPS13A_uc004akp.3_Missense_Mutation_p.D1067H|VPS13A_uc004akq.3_Missense_Mutation_p.D1067H|VPS13A_uc004aks.2_Intron	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1067					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CTTTATTCAAGATCAGAAATG	0.254		NA											10	10					0	0	0	0
KIF27	55582	broad.mit.edu	37	9	86518343	86518343	+	Missense_Mutation	SNP	T	T	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr9:86518343T>G	uc004ana.2	-	4	1234	c.1090A>C	c.(1090-1092)AAA>CAA	p.K364Q	KIF27_uc010mpw.2_Missense_Mutation_p.K364Q|KIF27_uc010mpx.2_Missense_Mutation_p.K364Q	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	364	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						CGAAGCAATTTAATCTCAAAT	0.433		NA											19	57					0	0	0	0
MID1	4281	broad.mit.edu	37	X	10535569	10535569	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:10535569C>A	uc004cte.3	-	2	210	c.19G>T	c.(19-21)GAA>TAA	p.E7*	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Nonsense_Mutation_p.E7*|MID1_uc004cth.3_Nonsense_Mutation_p.E7*|MID1_uc004ctk.3_Nonsense_Mutation_p.E7*|MID1_uc004cti.3_Nonsense_Mutation_p.E7*|MID1_uc004ctj.3_Nonsense_Mutation_p.E7*|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Nonsense_Mutation_p.E7*|MID1_uc004ctn.1_Nonsense_Mutation_p.E7*|MID1_uc004cto.1_Nonsense_Mutation_p.E7*|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Nonsense_Mutation_p.E7*|MID1_uc004ctu.2_Nonsense_Mutation_p.E7*|MID1_uc004ctv.2_Nonsense_Mutation_p.E7*|MID1_uc004ctw.2_Nonsense_Mutation_p.E7*|MID1_uc010ndy.1_Nonsense_Mutation_p.E7*|uc010ndz.1_5'Flank|MID1_uc004cty.2_Nonsense_Mutation_p.E7*|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Nonsense_Mutation_p.E7*|MID1_uc010nea.1_5'Flank|MID1_uc004cuc.1_Nonsense_Mutation_p.E7*|MID1_uc004cud.1_Nonsense_Mutation_p.E7*|MID1_uc004cue.1_Nonsense_Mutation_p.E7*|MID1_uc004cuf.1_Nonsense_Mutation_p.E7*|MID1_uc004cug.1_Nonsense_Mutation_p.E7*	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	7					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						CAGGTCAGTTCTGACTCCAGT	0.493		NA											28	20					4.88e-14	5.98e-14	1	0
GPR64	10149	broad.mit.edu	37	X	19022940	19022940	+	Missense_Mutation	SNP	A	A	G			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:19022940A>G	uc004cyx.2	-	23	2061	c.1897T>C	c.(1897-1899)TAT>CAT	p.Y633H	GPR64_uc004cyy.2_Missense_Mutation_p.Y630H|GPR64_uc004cyz.2_Missense_Mutation_p.Y619H|GPR64_uc004czb.2_Missense_Mutation_p.Y633H|GPR64_uc004czc.2_Missense_Mutation_p.Y617H|GPR64_uc004czd.2_Missense_Mutation_p.Y609H|GPR64_uc004cze.2_Missense_Mutation_p.Y603H|GPR64_uc004czf.2_Missense_Mutation_p.Y595H|GPR64_uc004cza.2_Missense_Mutation_p.Y611H|GPR64_uc004cyw.2_Missense_Mutation_p.Y617H|GPR64_uc010nfj.2_Missense_Mutation_p.Y514H	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	633	Helical; Name=1; (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					CAACCAATATATGTAATGAAC	0.353		NA											27	56					0	0	0	0
KDM6A	7403	broad.mit.edu	37	X	44922694	44922694	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:44922694C>T	uc004dge.3	+	16	1930	c.1555C>T	c.(1555-1557)CGA>TGA	p.R519*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R485*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R571*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R474*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R526*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R223*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R158*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	519					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGCACAGGTACGATCTACTGG	0.463		NA	D|N|F|S		renal|oesophageal SCC|MM								18	37					0	0	0	0
ZNF711	7552	broad.mit.edu	37	X	84526033	84526033	+	Silent	SNP	G	G	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:84526033G>A	uc004eeo.2	+	9	1832	c.1485G>A	c.(1483-1485)TTG>TTA	p.L495L	ZNF711_uc004eep.2_Silent_p.L495L|ZNF711_uc004eeq.2_Silent_p.L541L|ZNF711_uc011mqy.1_Silent_p.L94L	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	495	C2H2-type 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						ACAGGCATTTGTTGGCCGTTC	0.408		NA											3	29					0	0	0	0
RGAG1	57529	broad.mit.edu	37	X	109696372	109696372	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:109696372G>T	uc004eor.1	+	3	2773	c.2527G>T	c.(2527-2529)GGA>TGA	p.G843*	RGAG1_uc011msr.1_Nonsense_Mutation_p.G843*	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	843										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TCCCATCTCTGGAGCAATGTC	0.517		NA											61	32					1.5e-40	1.88e-40	1	0
VPS13D	55187	broad.mit.edu	37	1	12414089	12414090	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:12414089_12414090delTC	uc001atv.2	+	47	9631_9632	c.9490_9491delTC	c.(9490-9492)TCTfs	p.S3164fs	VPS13D_uc001atw.2_Frame_Shift_Del_p.S3139fs|VPS13D_uc001atx.2_Frame_Shift_Del_p.S2351fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3163					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAACATATTTTCTGACAGTGCA	0.356		NA											7	47	---	---	---	---	NA	NA	NA	NA
LGR4	55366	broad.mit.edu	37	11	27390526	27390527	+	Frame_Shift_Ins	INS	-	-	AGAAATCA			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:27390526_27390527insAGAAATCA	uc001mrj.3	-	18	2228_2229	c.1743_1744insTGATTTCT	c.(1741-1746)TCTGTGfs	p.S581fs	LGR4_uc001mrk.3_Frame_Shift_Ins_p.S557fs	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	581_582	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						AAGTTAGACACAGAAATCAAGC	0.386		NA											13	57	---	---	---	---	NA	NA	NA	NA
JUB	84962	broad.mit.edu	37	14	23451177	23451177	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr14:23451177delG	uc001whz.2	-	1	675	c.299delC	c.(298-300)CCTfs	p.P100fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	100	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTGAGGTAGAGGCAAGGCCCG	0.701		NA											4	4	---	---	---	---	NA	NA	NA	NA
HERC2	8924	broad.mit.edu	37	15	28446658	28446659	+	Frame_Shift_Ins	INS	-	-	T	rs146159039	byFrequency	TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:28446658_28446659insT	uc001zbj.2	-	48	7765_7766	c.7659_7660insA	c.(7657-7662)AAACGAfs	p.K2553fs	HERC2_uc001zbk.1_Frame_Shift_Ins_p.K88fs	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2553_2554					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAATCAGCTCGTTTTTTGTACG	0.366		NA											27	59	---	---	---	---	NA	NA	NA	NA
VASN	114990	broad.mit.edu	37	16	4432380	4432381	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:4432380_4432381insA	uc002cwj.1	+	2	1657_1658	c.1502_1503insA	c.(1501-1503)CTAfs	p.L501fs	CORO7_uc002cwe.2_Intron|CORO7_uc002cwf.2_Intron|CORO7_uc002cwg.3_Intron|CORO7_uc002cwh.3_Intron|CORO7_uc010uxh.1_Intron|CORO7_uc010uxi.1_Intron|CORO7_uc002cwi.1_Intron|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_Intron	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	slit-like 2 precursor	501	Fibronectin type-III.|Extracellular (Potential).					extracellular region|integral to membrane					0						TATCGCAACCTATCGGGCCCTG	0.668		NA											8	14	---	---	---	---	NA	NA	NA	NA
ZFHX3	463	broad.mit.edu	37	16	72822585	72822586	+	Frame_Shift_Ins	INS	-	-	G	rs141461385		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:72822585_72822586insG	uc002fck.2	-	10	10262_10263	c.9589_9590insC	c.(9589-9591)CAGfs	p.Q3197fs	ZFHX3_uc002fcl.2_Frame_Shift_Ins_p.Q2283fs	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3197	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				ctgctgctgctgGGGGGGTTGC	0.53		NA											23	118	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7577115	7577116	+	In_Frame_Ins	INS	-	-	AAC			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:7577115_7577116insAAC	uc002gim.2	-	8	1016_1017	c.822_823insGTT	c.(820-825)insGTT	p.274_275insV	TP53_uc002gig.1_Intron|TP53_uc002gih.2_In_Frame_Ins_p.274_275insV|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Ins_p.142_143insV|TP53_uc010cng.1_In_Frame_Ins_p.142_143insV|TP53_uc002gii.1_In_Frame_Ins_p.142_143insV|TP53_uc010cnh.1_In_Frame_Ins_p.274_275insV|TP53_uc010cni.1_In_Frame_Ins_p.274_275insV|TP53_uc002gij.2_In_Frame_Ins_p.274_275insV	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	274_275	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V274F(17)|p.V274A(13)|p.V274L(9)|p.C275G(7)|p.V274D(7)|p.0?(7)|p.C275R(6)|p.V274G(6)|p.V274I(4)|p.V274V(3)|p.C275fs*31(2)|p.?(2)|p.V274fs*71(1)|p.R273_C275delRVC(1)|p.V274_P278del(1)|p.C275fs*70(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGACAGGCACAAACACGCACCT	0.55		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	19	---	---	---	---	NA	NA	NA	NA
CD28	940	broad.mit.edu	37	2	204591669	204591669	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:204591669delC	uc002vah.3	+	2	588	c.366delC	c.(364-366)TACfs	p.Y122fs	CD28_uc002vag.1_Intron|CD28_uc010zio.1_Intron|CD28_uc010ftx.2_Intron|CD28_uc002vaj.3_Intron	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	122	Extracellular (Potential).|Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						CTCCTCCTTACCTAGACAATG	0.368		NA											16	28	---	---	---	---	NA	NA	NA	NA
MFSD7	84179	broad.mit.edu	37	4	678633	678634	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:678633_678634insA	uc003gay.2	-	5	654_655	c.597_598insT	c.(595-600)TATACCfs	p.Y199fs	MFSD7_uc003gaw.2_5'UTR|MFSD7_uc003gax.2_Frame_Shift_Ins_p.Y199fs|MFSD7_uc003gaz.2_Frame_Shift_Ins_p.Y80fs|MFSD7_uc003gba.2_Frame_Shift_Ins_p.Y102fs|MFSD7_uc003gbb.1_Frame_Shift_Ins_p.Y135fs	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	199_200	Helical; (Potential).				transmembrane transport	integral to membrane					0						GCAGGGATGGTATAGACACCGA	0.683		NA											6	11	---	---	---	---	NA	NA	NA	NA
PDZD2	23037	broad.mit.edu	37	5	32098603	32098604	+	Frame_Shift_Ins	INS	-	-	ACAA			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:32098603_32098604insACAA	uc003jhl.2	+	23	8469_8470	c.8081_8082insACAA	c.(8080-8082)GCAfs	p.A2694fs	PDZD2_uc003jhm.2_Frame_Shift_Ins_p.A2694fs|PDZD2_uc003jhn.2_5'Flank	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2694	PDZ 5.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTGCACCAGGCACAGCTGCACA	0.594		NA											19	32	---	---	---	---	NA	NA	NA	NA
CAPN11	11131	broad.mit.edu	37	6	44148689	44148702	+	Frame_Shift_Del	DEL	GGGCTTTGGCCTGG	GGGCTTTGGCCTGG	-			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr6:44148689_44148702delGGGCTTTGGCCTGG	uc003owt.1	+	18	1862_1875	c.1824_1837delGGGCTTTGGCCTGG	c.(1822-1839)AAGGGCTTTGGCCTGGATfs	p.K608fs	CAPN11_uc011dvn.1_Frame_Shift_Del_p.K262fs	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	608_613	EF-hand 1.|Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCAAGACCAAGGGCTTTGGCCTGGATGCTTGCCG	0.57		NA											36	209	---	---	---	---	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113569097	113569119	+	Frame_Shift_Del	DEL	TGGTGCTACCAGCAAAGTGGCCT	TGGTGCTACCAGCAAAGTGGCCT	-	rs143731892	byFrequency	TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:113569097_113569119delTGGTGCTACCAGCAAAGTGGCCT	uc003ynu.2	-	25	4266_4288	c.4107_4129delAGGCCACTTTGCTGGTAGCACCA	c.(4105-4131)CAAGGCCACTTTGCTGGTAGCACCATCfs	p.Q1369fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.Q641fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.Q1329fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.Q1265fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1369_1377	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCATAAATGATGGTGCTACCAGCAAAGTGGCCTTGGTCACTGA	0.453		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	36	---	---	---	---	NA	NA	NA	NA