Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PER3	8863	broad.mit.edu	37	1	7870006	7870006	+	Silent	SNP	G	G	T	rs139242507		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:7870006G>T	uc001aoo.2	+	11	1468	c.1293G>T	c.(1291-1293)TCG>TCT	p.S431S	PER3_uc009vmg.1_Silent_p.S432S|PER3_uc009vmh.1_Silent_p.S432S|PER3_uc001aop.2_Silent_p.S432S|PER3_uc010nzw.1_Silent_p.S113S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGCGGGTCGCAGGAGCAGC	0.592		NA											11	34					9.7e-10	2.03e-09	1	0
PRAMEF12	390999	broad.mit.edu	37	1	12837316	12837316	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:12837316G>A	uc001aui.2	+	3	1053	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	342										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCAGTTCTGCTGGAGCAAG	0.587		NA											16	55					0	0	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855677	12855677	+	Silent	SNP	C	C	G	rs142654121		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:12855677C>G	uc001auj.1	+	4	1060	c.957C>G	c.(955-957)CTC>CTG	p.L319L		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	319	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCAAGCCTCGGTTACCTAA	0.493		NA											23	110					0	0	0	0
MAGI3	260425	broad.mit.edu	37	1	114184803	114184803	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:114184803C>T	uc001edk.2	+	10	1812	c.1631C>T	c.(1630-1632)TCG>TTG	p.S544L	MAGI3_uc001edh.3_Missense_Mutation_p.S569L|MAGI3_uc001edi.3_Missense_Mutation_p.S544L|MAGI3_uc010owm.1_Missense_Mutation_p.S569L|MAGI3_uc001edj.2_Missense_Mutation_p.S265L	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	569					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AATGGAAAATCGGGACACACT	0.493		NA											28	79					0	0	0	0
HMGCS2	3158	broad.mit.edu	37	1	120296002	120296002	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:120296002C>A	uc001eid.2	-	7	1246	c.1195G>T	c.(1195-1197)GCC>TCC	p.A399S	HMGCS2_uc010oxj.1_Missense_Mutation_p.A357S|HMGCS2_uc001eie.2_Missense_Mutation_p.A307S	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	399					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		AGTTCTTGGGCAGAGTGGCTG	0.348		NA											9	23					1.34e-11	2.81e-11	1	0
THEM4	117145	broad.mit.edu	37	1	151867562	151867562	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:151867562C>T	uc001ezj.1	-	2	387	c.208G>A	c.(208-210)GAC>AAC	p.D70N	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	70					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGGAGCCGTCTTCACATTTC	0.433		NA											4	89					0	0	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058810	152058810	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:152058810C>T	uc001ezo.1	-	3	1413	c.1348G>A	c.(1348-1350)GAA>AAA	p.E450K		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	450							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCTCCTCCTTCTGAGCTTAGA	0.448		NA											18	192					0	0	0	0
CCDC19	25790	broad.mit.edu	37	1	159857775	159857775	+	Silent	SNP	G	G	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:159857775G>T	uc001fui.2	-	5	462	c.444C>A	c.(442-444)ATC>ATA	p.I148I	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Silent_p.I63I|CCDC19_uc001ful.2_Silent_p.I63I|CCDC19_uc009wtc.1_Silent_p.I148I	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	148						mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TCTGTTTCATGATCTTCTTTC	0.542		NA											29	54					1.56e-20	3.33e-20	1	0
SELE	6401	broad.mit.edu	37	1	169701064	169701064	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:169701064G>A	uc001ggm.3	-	4	598	c.441C>T	c.(439-441)TCC>TCT	p.S147S	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	147	EGF-like.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GGCCACTGCAGGATGTATTGG	0.438		NA											11	20					0	0	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174606603	174606603	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:174606603G>A	uc001gjx.2	+	14	1996	c.1801G>A	c.(1801-1803)GAA>AAA	p.E601K		NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	601	Rab-GAP TBC.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						AGATGGTCAAGAATCGCTCTA	0.358		NA											16	57					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186273956	186273956	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:186273956C>G	uc001gru.3	+	6	551	c.500C>G	c.(499-501)TCC>TGC	p.S167C	PRG4_uc001grt.3_Missense_Mutation_p.S126C|PRG4_uc009wyl.2_Intron|PRG4_uc009wym.2_Intron|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	167	Ser-rich.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAGAGtcctcctcctcctcc	0.259		NA											4	40					0	0	0	0
CDC73	79577	broad.mit.edu	37	1	193104562	193104562	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:193104562G>A	uc001gtb.2	+	4	592	c.349G>A	c.(349-351)GGT>AGT	p.G117S	MIR1278_hsa-mir-1278|MI0006425_5'Flank	NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	117					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						CTTAGAAATAGGTCTTCAGCG	0.333		NA							Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				23	42					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197115445	197115445	+	Silent	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:197115445G>C	uc001gtu.2	-	1	380	c.123C>G	c.(121-123)CTC>CTG	p.L41L	ASPM_uc001gtv.2_Silent_p.L41L|ASPM_uc001gtw.3_5'UTR	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	41					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGAAGTGGCTGAGAGACAGGA	0.373		NA											10	50					0	0	0	0
OR2M3	127062	broad.mit.edu	37	1	248366902	248366902	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:248366902T>C	uc010pzg.1	+	1	533	c.533T>C	c.(532-534)TTC>TCC	p.F178S		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCCACTTCTTCTGTGACTTC	0.423		NA											38	182					0	0	0	0
OR2M7	391196	broad.mit.edu	37	1	248487479	248487479	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:248487479C>G	uc010pzk.1	-	1	392	c.392G>C	c.(391-393)AGA>ACA	p.R131T		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTGGTGTATCTTAGAGGGTG	0.438		NA											8	241					0	0	0	0
FBXO18	84893	broad.mit.edu	37	10	5948405	5948405	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:5948405G>A	uc001iis.2	+	3	658	c.563G>A	c.(562-564)GGT>GAT	p.G188D	FBXO18_uc001iir.2_Missense_Mutation_p.G114D|FBXO18_uc009xig.2_Missense_Mutation_p.G114D|FBXO18_uc001iit.2_Missense_Mutation_p.G239D	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	188					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GGGGACGTGGGTCCTGATCCC	0.448		NA											5	19					0	0	0	0
APBB1IP	54518	broad.mit.edu	37	10	26785285	26785285	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:26785285A>T	uc001iss.2	+	4	446	c.125A>T	c.(124-126)GAA>GTA	p.E42V	APBB1IP_uc001isr.2_Missense_Mutation_p.E42V|APBB1IP_uc009xks.1_Missense_Mutation_p.E42V	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	42					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CCCAGAGCTGAATTTAACTAC	0.343		NA											18	56					0	0	0	0
PARD3	56288	broad.mit.edu	37	10	34408630	34408630	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:34408630C>T	uc010qej.1	-	24	3588	c.3588G>A	c.(3586-3588)TCG>TCA	p.S1196S	PARD3_uc010qek.1_Silent_p.S1193S|PARD3_uc010qel.1_Silent_p.S1159S|PARD3_uc010qem.1_Silent_p.S1180S|PARD3_uc010qen.1_Silent_p.S1150S|PARD3_uc010qeo.1_Silent_p.S1113S|PARD3_uc010qep.1_Silent_p.S1106S|PARD3_uc010qeq.1_Silent_p.S1084S	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1196					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CCACGGACACCGAGTGTCGCC	0.617		NA											5	11					0	0	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974590	64974590	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:64974590G>C	uc001jmn.2	-	8	1637	c.1337C>G	c.(1336-1338)GCA>GGA	p.A446G	JMJD1C_uc001jml.2_Missense_Mutation_p.A227G|JMJD1C_uc001jmm.2_Missense_Mutation_p.A158G|JMJD1C_uc010qiq.1_Missense_Mutation_p.A264G|JMJD1C_uc009xpi.2_Missense_Mutation_p.A264G|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.A158G	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	446					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCGCTTCTCTGCTTCTTCATG	0.388		NA											29	42					0	0	0	0
CTNNA3	29119	broad.mit.edu	37	10	67726429	67726429	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:67726429T>A	uc009xpn.1	-	17	2464	c.2341A>T	c.(2341-2343)ATC>TTC	p.I781F	CTNNA3_uc001jmw.2_Missense_Mutation_p.I781F	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	781					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TGACTGCAGATTTTCAGTTGG	0.428		NA											14	46					0	0	0	0
GRID1	2894	broad.mit.edu	37	10	87614310	87614310	+	Silent	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:87614310G>C	uc001kdl.1	-	8	1277	c.1176C>G	c.(1174-1176)GTC>GTG	p.V392V	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	392	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTTCAAACTGGACATAGGGAT	0.498		NA								Multiple Myeloma(13;0.14)			10	34					0	0	0	0
WAPAL	23063	broad.mit.edu	37	10	88259533	88259533	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:88259533C>T	uc001kdo.2	-	3	1909	c.1467G>A	c.(1465-1467)CAG>CAA	p.Q489Q	WAPAL_uc001kdn.2_Silent_p.Q532Q|WAPAL_uc009xsw.2_Silent_p.Q489Q	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	489	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CTGGGGGAGGCTGCAAGGAGG	0.358		NA											18	63					0	0	0	0
HPS6	79803	broad.mit.edu	37	10	103826369	103826369	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:103826369G>A	uc001kuj.2	+	1	1223	c.1138G>A	c.(1138-1140)GCC>ACC	p.A380T		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	380						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		TCTGCTTTCAGCCTTGGGTCT	0.582		NA							Hermansky-Pudlak_syndrome				5	39					0	0	0	0
TAF5	6877	broad.mit.edu	37	10	105133180	105133180	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:105133180G>A	uc001kwv.2	+	2	648	c.625G>A	c.(625-627)GGA>AGA	p.G209R	TAF5_uc010qqq.1_Missense_Mutation_p.G209R	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	209					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CAACCAACAAGGAGATCCCAC	0.413		NA											8	87					0	0	0	0
APBB1	322	broad.mit.edu	37	11	6425033	6425033	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr11:6425033G>A	uc001mdb.1	-	3	841	c.741C>T	c.(739-741)AAC>AAT	p.N247N	APBB1_uc001mcz.1_5'Flank|APBB1_uc001mdd.3_Silent_p.N27N|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Silent_p.N247N|APBB1_uc010rab.1_5'Flank|APBB1_uc010rac.1_5'Flank|APBB1_uc010rad.1_5'Flank|APBB1_uc010rae.1_Silent_p.N12N|APBB1_uc010raf.1_Translation_Start_Site|APBB1_uc009yfa.2_Translation_Start_Site|APBB1_uc009yey.2_Translation_Start_Site|APBB1_uc010rag.1_Translation_Start_Site|APBB1_uc009yfb.2_Translation_Start_Site|APBB1_uc001mde.2_Translation_Start_Site|APBB1_uc010rah.1_Translation_Start_Site	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	247					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TCTCGAAGGCGTTGGGGTTCC	0.617		NA											17	14					0	0	0	0
DCHS1	8642	broad.mit.edu	37	11	6646039	6646039	+	Missense_Mutation	SNP	G	G	A	rs141901540		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr11:6646039G>A	uc001mem.1	-	20	7617	c.7207C>T	c.(7207-7209)CGG>TGG	p.R2403W		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2403	Cadherin 23.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGAGTCCCGATCAGTGGCA	0.557		NA											6	9					0	0	0	0
GALNT8	26290	broad.mit.edu	37	12	4855415	4855415	+	Silent	SNP	T	T	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:4855415T>C	uc001qne.1	+	6	1256	c.1164T>C	c.(1162-1164)CTT>CTC	p.L388L		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	388	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						ACGTGGAGCTTAGCCTGAGGG	0.498		NA											4	45					0	0	0	0
CD163L1	283316	broad.mit.edu	37	12	7559320	7559320	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:7559320C>T	uc001qsy.2	-	5	921	c.895G>A	c.(895-897)GTA>ATA	p.V299I	CD163L1_uc010sge.1_Missense_Mutation_p.V309I	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	299	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCTTGCATACGACATCAGCT	0.522		NA											22	55					0	0	0	0
BRAP	8315	broad.mit.edu	37	12	112082288	112082288	+	Silent	SNP	T	T	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:112082288T>C	uc001tsn.3	-	12	1688	c.1494A>G	c.(1492-1494)CGA>CGG	p.R498R	BRAP_uc010syh.1_Silent_p.R319R|BRAP_uc009zvv.2_Silent_p.R468R	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	498	Potential.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						CTTGGTTGGCTCGCAAACACT	0.483		NA											20	78					0	0	0	0
RPLP0	6175	broad.mit.edu	37	12	120636708	120636708	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:120636708G>C	uc001txp.2	-	5	651	c.414C>G	c.(412-414)TTC>TTG	p.F138L	RPLP0_uc001txq.2_Missense_Mutation_p.F138L|RPLP0_uc001txr.2_Missense_Mutation_p.F138L|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	138					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAAAGCCTGGAAAAAGGAGG	0.567		NA											6	18					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123812541	123812541	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:123812541A>C	uc010tap.1	-	10	1330	c.1330T>G	c.(1330-1332)TTA>GTA	p.L444V	SBNO1_uc010tao.1_Missense_Mutation_p.L443V|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.L444V|SBNO1_uc001ueu.2_Missense_Mutation_p.L443V|SBNO1_uc001uev.2_Missense_Mutation_p.L442V|SBNO1_uc009zxy.1_Missense_Mutation_p.L409V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	444							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ACAGGACATAAGTTTTTGGCT	0.368		NA											14	70					0	0	0	0
MTUS2	23281	broad.mit.edu	37	13	29599504	29599504	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr13:29599504C>T	uc001usl.3	+	1	757	c.699C>T	c.(697-699)CAC>CAT	p.H233H		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	223						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TGCCAGACCACGCTGTCCCGG	0.587		NA											6	9					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109318469	109318469	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr13:109318469C>T	uc001vqt.1	+	2	324	c.198C>T	c.(196-198)GAC>GAT	p.D66D	MYO16_uc010agk.1_Silent_p.D88D	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	66	ANK 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TGCTACAGGACGCGATTATCC	0.428		NA											4	16					0	0	0	0
MMP14	4323	broad.mit.edu	37	14	23313687	23313687	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:23313687G>C	uc001whc.2	+	7	1353	c.1119G>C	c.(1117-1119)GAG>GAC	p.E373D		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	373	Hemopexin-like 2.|Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CTGCCTACGAGAGGAAGGATG	0.537		NA											15	170					0	0	0	0
HECTD1	25831	broad.mit.edu	37	14	31619322	31619322	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:31619322C>T	uc001wrc.1	-	13	2527	c.2038G>A	c.(2038-2040)GAT>AAT	p.D680N	HECTD1_uc001wrd.1_Missense_Mutation_p.D195N	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	680					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCTGCTGCATCACTCCAAATA	0.418		NA											19	147					0	0	0	0
BAZ1A	11177	broad.mit.edu	37	14	35343736	35343736	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:35343736G>C	uc001wsk.2	-	2	643	c.75C>G	c.(73-75)TTC>TTG	p.F25L	BAZ1A_uc001wsl.2_Missense_Mutation_p.F25L|BAZ1A_uc001wsm.1_Missense_Mutation_p.F25L	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	25	WAC.|Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CTTTACAGTAGAAAACTTCCT	0.667		NA											4	58					0	0	0	0
MDGA2	161357	broad.mit.edu	37	14	47530684	47530684	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:47530684T>A	uc001wwj.3	-	7	1282	c.1086A>T	c.(1084-1086)GAA>GAT	p.E362D	MDGA2_uc001wwi.3_Missense_Mutation_p.E133D|MDGA2_uc010ani.2_Translation_Start_Site	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	362	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						AAGGAACAGCTTCTACTTGGC	0.403		NA											40	64					0	0	0	0
DUOX1	53905	broad.mit.edu	37	15	45437213	45437213	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr15:45437213G>T	uc001zus.1	+	19	2603	c.2257G>T	c.(2257-2259)GCA>TCA	p.A753S	DUOX1_uc001zut.1_Missense_Mutation_p.A753S|DUOX1_uc010bee.1_Missense_Mutation_p.A133S|DUOX1_uc001zuu.2_5'Flank	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	753	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GCTGATGAGAGCAGCTGTGAC	0.592		NA											7	61					5.18e-06	1.05e-05	1	0
BLM	641	broad.mit.edu	37	15	91312807	91312807	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr15:91312807G>C	uc002bpr.2	+	12	2643	c.2546G>C	c.(2545-2547)AGA>ACA	p.R849T	BLM_uc010uqh.1_Missense_Mutation_p.R849T|BLM_uc010uqi.1_Missense_Mutation_p.R474T|BLM_uc010bnx.2_Missense_Mutation_p.R849T|BLM_uc002bps.1_Missense_Mutation_p.R411T	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	849	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AAGATTCTCAGACCTCAGGTG	0.517		NA	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				4	27					0	0	0	0
MSLN	10232	broad.mit.edu	37	16	816458	816458	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:816458G>C	uc002cjw.1	+	12	1249	c.1198G>C	c.(1198-1200)GAA>CAA	p.E400Q	MSLN_uc002cjt.1_Missense_Mutation_p.E400Q|MSLN_uc002cju.1_Missense_Mutation_p.E400Q|MSLN_uc010brd.1_Missense_Mutation_p.E399Q|MSLN_uc002cjv.1_Missense_Mutation_p.E400Q|MSLN_uc002cjx.1_Missense_Mutation_p.E400Q|MSLN_uc002cjy.1_Missense_Mutation_p.E65Q	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	400					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GGCTTTGCTTGAAGTCAACAA	0.572		NA											10	62					0	0	0	0
SETD6	79918	broad.mit.edu	37	16	58550236	58550236	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:58550236C>T	uc002ens.2	+	3	524	c.465C>T	c.(463-465)CAC>CAT	p.H155H	SETD6_uc010cdl.2_Silent_p.H155H|SETD6_uc002enr.2_Silent_p.H131H|SETD6_uc010cdm.2_RNA|SETD6_uc010vij.1_Silent_p.H79H	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	155	SET.				negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						GCTTGGAGCACCCGATGTTCT	0.672		NA											5	34					0	0	0	0
FTSJD1	55783	broad.mit.edu	37	16	71318560	71318560	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:71318560T>A	uc010cga.2	-	3	1670	c.1264A>T	c.(1264-1266)AAA>TAA	p.K422*	FTSJD1_uc002ezy.3_Nonsense_Mutation_p.K422*|FTSJD1_uc002ezz.3_Nonsense_Mutation_p.K422*	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	422						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						ATACTAGATTTTTTTACTAGC	0.299		NA											7	62					0	0	0	0
DHODH	1723	broad.mit.edu	37	16	72046004	72046004	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:72046004C>A	uc002fbp.2	+	2	98	c.77C>A	c.(76-78)TCC>TAC	p.S26Y	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	26	Helical; (By similarity).				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	CTCTTCGCCTCCTACCTGATG	0.602		NA											16	105					1.36e-06	2.77e-06	1	0
CDT1	81620	broad.mit.edu	37	16	88873832	88873832	+	Silent	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:88873832C>G	uc002flu.2	+	9	1473	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	473					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		AGCCTGCGCTCAGCATGGAGG	0.657		NA											5	47					0	0	0	0
ALOX12	239	broad.mit.edu	37	17	6909233	6909233	+	Silent	SNP	G	G	A	rs114312186	byFrequency	TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:6909233G>A	uc002gdx.3	+	10	1358	c.1305G>A	c.(1303-1305)CAG>CAA	p.Q435Q	uc002gdy.1_Intron	NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	435	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						CGGCAGCTCAGCTGACCTACT	0.632		NA											3	27					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578532	7578532	+	Missense_Mutation	SNP	A	A	T	rs28934873		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:7578532A>T	uc002gim.2	-	5	592	c.398T>A	c.(397-399)ATG>AAG	p.M133K	TP53_uc002gig.1_Missense_Mutation_p.M133K|TP53_uc002gih.2_Missense_Mutation_p.M133K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M1K|TP53_uc010cng.1_Missense_Mutation_p.M1K|TP53_uc002gii.1_Missense_Mutation_p.M1K|TP53_uc010cnh.1_Missense_Mutation_p.M133K|TP53_uc010cni.1_Missense_Mutation_p.M133K|TP53_uc002gij.2_Missense_Mutation_p.M133K|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M40K|TP53_uc002gio.2_Missense_Mutation_p.M1K|TP53_uc010vug.1_Missense_Mutation_p.M94K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	133	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		KM -> NL (in a sporadic cancer; somatic mutation).|M -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M133K(12)|p.0?(7)|p.M133R(5)|p.M133fs*37(3)|p.M133I(3)|p.M133L(2)|p.N131fs*27(2)|p.M133T(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.Y126fs*11(1)|p.M133V(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.L130_M133delLNKM(1)|p.M133fs*16(1)|p.M133fs*13(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCAAAACATCTTGTTGAG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	12					0	0	0	0
STX8	9482	broad.mit.edu	37	17	9448488	9448488	+	Splice_Site	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:9448488C>T	uc002glx.2	-	4	473	c.323_splice	c.e4+1	p.R108_splice		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						AAACATCCTACCTGATTAGAT	0.418		NA											5	36					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11511572	11511572	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:11511572G>A	uc002gne.2	+	2	612	c.544G>A	c.(544-546)GGA>AGA	p.G182R	DNAH9_uc002gnd.1_Missense_Mutation_p.G182R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	182	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCAAGTGAAGGGAAAAACTTT	0.512		NA											10	118					0	0	0	0
CNP	1267	broad.mit.edu	37	17	40125676	40125676	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:40125676G>A	uc002hyl.1	+	4	1144	c.1000G>A	c.(1000-1002)GGC>AGC	p.G334S	CNP_uc010wfz.1_Missense_Mutation_p.G211S|CNP_uc002hym.1_Missense_Mutation_p.G314S|CNP_uc010wga.1_Missense_Mutation_p.G99S|CNP_uc002hyn.1_Missense_Mutation_p.G99S	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	334					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		CATCACCCTCGGCTGTGCAGC	0.647		NA											7	38					0	0	0	0
NMT1	4836	broad.mit.edu	37	17	43175850	43175850	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:43175850C>T	uc002ihz.2	+	7	832	c.814C>T	c.(814-816)CAC>TAC	p.H272Y	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	272					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				CAGGCGGGTTCACCTGGAGGG	0.527		NA											11	100					0	0	0	0
MYO5B	4645	broad.mit.edu	37	18	47373592	47373592	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr18:47373592C>T	uc002leb.2	-	33	4671	c.4383G>A	c.(4381-4383)CGG>CGA	p.R1461R	MYO5B_uc002ldz.2_Silent_p.R31R|MYO5B_uc002lea.2_Silent_p.R576R	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1461	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CCTTCTCTTTCCGCTGGACCG	0.572		NA											8	26					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9048921	9048921	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:9048921C>T	uc002mkp.2	-	5	32914	c.32710G>A	c.(32710-32712)GAG>AAG	p.E10904K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10906	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGTGGTCTCTGGTTCACCA	0.502		NA											14	65					0	0	0	0
CHERP	10523	broad.mit.edu	37	19	16629998	16629998	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:16629998C>G	uc002nei.1	-	17	2797	c.2723G>C	c.(2722-2724)CGC>CCC	p.R908P	MED26_uc002nee.2_RNA|C19orf44_uc002neh.1_Intron|C19orf44_uc010eai.1_Intron|CHERP_uc010xpg.1_Missense_Mutation_p.R447P	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	908					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GGCCTTCATGCGGGCGATGAA	0.637		NA											3	13					0	0	0	0
SPTBN4	57731	broad.mit.edu	37	19	40993612	40993612	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:40993612G>A	uc002ony.2	+	3	264	c.178G>A	c.(178-180)GAA>AAA	p.E60K	SPTBN4_uc002onx.2_Missense_Mutation_p.E60K|SPTBN4_uc002onz.2_Missense_Mutation_p.E60K	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	60	Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGATGAGCGGGAAGCCGTGCA	0.647		NA											8	103					0	0	0	0
PSG6	5675	broad.mit.edu	37	19	43414874	43414874	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:43414874C>T	uc002ovj.1	-	3	616	c.564G>A	c.(562-564)ATG>ATA	p.M188I	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.M195I|PSG6_uc002ovi.2_Missense_Mutation_p.M189I|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_5'UTR|PSG6_uc002ovf.1_Missense_Mutation_p.M188I|PSG6_uc002ovg.1_Missense_Mutation_p.M188I	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	188	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				ACCTGTGAGTCATAGGGAGGT	0.493		NA											86	145					0	0	0	0
FTL	2512	broad.mit.edu	37	19	49468783	49468783	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:49468783C>T	uc002plo.2	+	1	218	c.19C>T	c.(19-21)CAG>TAG	p.Q7*	FTL_uc002pln.1_Nonsense_Mutation_p.Q7*	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	7	Ferritin-like diiron.				cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	CCAGATTCGTCAGAATTATTC	0.567		NA											69	52					0	0	0	0
LILRA5	353514	broad.mit.edu	37	19	54823872	54823872	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:54823872G>C	uc002qfe.2	-	2	143	c.23C>G	c.(22-24)TCT>TGT	p.S8C	LILRA5_uc002qff.2_Missense_Mutation_p.S8C|LILRA5_uc010yev.1_Missense_Mutation_p.S8C|LILRA5_uc010yew.1_Missense_Mutation_p.S8C|LILRA5_uc002qfh.1_Missense_Mutation_p.S8C|LILRA5_uc002qfg.1_Missense_Mutation_p.S8C	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	8					innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGCTGTGCAGATGGATGAGA	0.597		NA											5	40					0	0	0	0
SLC27A5	10998	broad.mit.edu	37	19	59011756	59011756	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:59011756G>T	uc002qtc.2	-	6	1528	c.1418C>A	c.(1417-1419)GCG>GAG	p.A473E	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	473	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		AGGCTCCGCCGCCTCCATGTC	0.627		NA											10	48					1.05e-09	2.19e-09	1	0
ANKRD36	375248	broad.mit.edu	37	2	97808556	97808556	+	Silent	SNP	A	A	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:97808556A>G	uc010yva.1	+	8	1129	c.885A>G	c.(883-885)GGA>GGG	p.G295G	ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_Intron|ANKRD36_uc002sxo.2_Intron|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	295											0						TAAAGGATGGACAAAAATCTG	0.318		NA											2	3					0	0	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120006	103120006	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:103120006G>A	uc002tbz.3	+	3	1277	c.820G>A	c.(820-822)GGG>AGG	p.G274R		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	274	Helical; Name=H/M6; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CATCGTTGTGGGGCTTGGAGG	0.393		NA											8	46					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179594065	179594065	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:179594065A>G	uc010zfg.1	-	61	15310	c.15086T>C	c.(15085-15087)GTA>GCA	p.V5029A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V1690A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5956							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATTGGATACAATGCACTG	0.433		NA											11	63					0	0	0	0
NCKAP1	10787	broad.mit.edu	37	2	183790481	183790481	+	Silent	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:183790481C>G	uc002upc.2	-	31	3738	c.3336G>C	c.(3334-3336)CTG>CTC	p.L1112L	NCKAP1_uc002upb.2_Silent_p.L1118L	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	1112					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			ATGCATTTCTCAGCAAGACAT	0.323		NA											7	78					0	0	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800736	185800736	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:185800736C>A	uc002uph.2	+	4	1207	c.613C>A	c.(613-615)CAG>AAG	p.Q205K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	205						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GGATCAAGCCCAGGGGATTCA	0.418		NA											23	56					1.97e-08	4.05e-08	1	0
COL5A2	1290	broad.mit.edu	37	2	189898825	189898825	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:189898825C>T	uc002uqk.2	-	54	4746	c.4471G>A	c.(4471-4473)GTT>ATT	p.V1491I	COL5A2_uc010frx.2_Missense_Mutation_p.V1067I	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1491	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAATTTCAACGCCGAATTCC	0.473		NA											7	51					0	0	0	0
RAPH1	65059	broad.mit.edu	37	2	204305402	204305402	+	Silent	SNP	C	C	G	rs144494517		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:204305402C>G	uc002vad.2	-	14	2736	c.2511G>C	c.(2509-2511)CCG>CCC	p.P837P		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	837					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						GTAATGTTGGCGGGGGTACTG	0.582		NA											7	34					0	0	0	0
BTG3	10950	broad.mit.edu	37	21	18981460	18981460	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr21:18981460C>A	uc002ykk.2	-	2	263	c.3G>T	c.(1-3)ATG>ATT	p.M1I	BTG3_uc002ykl.2_Missense_Mutation_p.M1I	NM_006806	NP_006797	Q14201	BTG3_HUMAN	B-cell translocation gene 3 isoform b	1					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm					0				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		TTTCATTCTTCATTTTTTTCC	0.348		NA											33	35					5.83e-16	1.24e-15	1	0
TRPM2	7226	broad.mit.edu	37	21	45833913	45833913	+	Silent	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr21:45833913C>G	uc002zet.1	+	21	3315	c.3102C>G	c.(3100-3102)CTC>CTG	p.L1034L	TRPM2_uc002zeu.1_Silent_p.L1034L|TRPM2_uc002zew.1_Silent_p.L1034L|TRPM2_uc010gpt.1_Silent_p.L1034L|TRPM2_uc002zex.1_Silent_p.L820L|TRPM2_uc002zey.1_Silent_p.L547L	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1034	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCTACCTGCTCTTCACCAACA	0.657		NA											38	299					0	0	0	0
XIRP1	165904	broad.mit.edu	37	3	39230859	39230859	+	Silent	SNP	T	T	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:39230859T>G	uc003cjk.1	-	2	299	c.78A>C	c.(76-78)CCA>CCC	p.P26P	XIRP1_uc003cji.2_Silent_p.P26P|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	26	Interaction with VASP.|Poly-Pro.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGCTGGGGGTGGAGGGAGGG	0.637		NA											5	7					0	0	0	0
TMEM22	80723	broad.mit.edu	37	3	136573702	136573702	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:136573702C>G	uc003erf.3	+	2	614	c.400C>G	c.(400-402)CTA>GTA	p.L134V	TMEM22_uc003erg.3_Missense_Mutation_p.L134V|TMEM22_uc010hub.2_Missense_Mutation_p.L134V	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	134	DUF6 1.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						AGTTCCATCTCTAGAACTGAT	0.428		NA											31	226					0	0	0	0
MECOM	2122	broad.mit.edu	37	3	168838959	168838959	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:168838959G>A	uc003ffi.3	-	6	722	c.453C>T	c.(451-453)CGC>CGT	p.R151R	MECOM_uc010hwk.1_Silent_p.R174R|MECOM_uc003ffj.3_Silent_p.R216R|MECOM_uc011bpi.1_Silent_p.R152R|MECOM_uc003ffn.3_Silent_p.R151R|MECOM_uc003ffk.2_Silent_p.R151R|MECOM_uc003ffl.2_Silent_p.R311R|MECOM_uc011bpj.1_Silent_p.R339R|MECOM_uc011bpk.1_Silent_p.R141R|MECOM_uc010hwn.2_Silent_p.R339R	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	151	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 4.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGCTGAGAGCGAATGTGCC	0.517		NA											39	22					0	0	0	0
MCF2L2	23101	broad.mit.edu	37	3	183017859	183017859	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:183017859G>A	uc003fli.1	-	11	1329	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I	MCF2L2_uc003flj.1_Silent_p.I413I|MCF2L2_uc011bqr.1_RNA|MCF2L2_uc003flp.1_3'UTR	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	413	Spectrin.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGTTTCCATTGATGAAATCGT	0.488		NA											17	104					0	0	0	0
PAK2	5062	broad.mit.edu	37	3	196529909	196529909	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:196529909C>G	uc003fwy.3	+	4	632	c.310C>G	c.(310-312)CGA>GGA	p.R104G		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	104	GTPase-binding (By similarity).|Autoregulatory region (By similarity).				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		ACAGTGGGCTCGATTACTACA	0.378		NA											4	90					0	0	0	0
STX18	53407	broad.mit.edu	37	4	4426946	4426946	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:4426946C>T	uc003gic.2	-	8	790	c.706G>A	c.(706-708)GAA>AAA	p.E236K		NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	236	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		TTTTCCTGTTCAAACTGTGAG	0.448		NA											5	33					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73957032	73957032	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:73957032G>C	uc003hgp.2	-	29	6430	c.6313C>G	c.(6313-6315)CAT>GAT	p.H2105D	ANKRD17_uc003hgo.2_Missense_Mutation_p.H1992D|ANKRD17_uc003hgq.2_Missense_Mutation_p.H1854D|ANKRD17_uc003hgr.2_Missense_Mutation_p.H2104D	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2105	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGATTAGAATGAGCTGATGAA	0.498		NA											11	124					0	0	0	0
TACR3	6870	broad.mit.edu	37	4	104579371	104579371	+	Splice_Site	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:104579371C>T	uc003hxe.1	-	2	880	c.737_splice	c.e2+1	p.T246_splice		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3							integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AATTAACTTACGTGAAATGTT	0.393		NA											16	50					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134072862	134072862	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:134072862G>A	uc003iha.2	+	1	2393	c.1567G>A	c.(1567-1569)GGC>AGC	p.G523S	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.G523S	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	523	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CTCTGAGAACGGCTACTTGTA	0.602		NA											17	68					0	0	0	0
FSTL5	56884	broad.mit.edu	37	4	163032465	163032465	+	Silent	SNP	A	A	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:163032465A>G	uc003iqh.2	-	2	520	c.84T>C	c.(82-84)TAT>TAC	p.Y28Y	FSTL5_uc003iqi.2_Silent_p.Y28Y|FSTL5_uc010iqv.2_Silent_p.Y28Y	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	28						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATTTAAGGCCATATCCTCCTT	0.408		NA											14	116					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127595501	127595501	+	Silent	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:127595501C>T	uc003kuu.2	-	65	8824	c.8385G>A	c.(8383-8385)GAG>GAA	p.E2795E		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2795					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGTCGACACTCTCTAGGCTGA	0.537		NA											11	68					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237196	140237196	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:140237196G>A	uc003lhx.2	+	1	1563	c.1563G>A	c.(1561-1563)CCG>CCA	p.P521P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.P521P|PCDHA10_uc011dad.1_Silent_p.P521P	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	521	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGCAGCCGCTGGACCACG	0.677		NA											9	82					0	0	0	0
PCDHGC3	5098	broad.mit.edu	37	5	140856119	140856119	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:140856119G>A	uc003lkv.1	+	1	551	c.436G>A	c.(436-438)GAG>AAG	p.E146K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.E146K|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	146	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGATTAGCGAGGCCGTGGC	0.547		NA											7	44					0	0	0	0
CDHR2	54825	broad.mit.edu	37	5	176011455	176011455	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:176011455G>A	uc003mem.1	+	19	2239	c.2173G>A	c.(2173-2175)GAA>AAA	p.E725K	CDHR2_uc003men.1_Missense_Mutation_p.E725K	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	725	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GGACCAGACGGAAGCCAACAA	0.637		NA											10	78					0	0	0	0
F12	2161	broad.mit.edu	37	5	176829658	176829658	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:176829658G>A	uc003mgo.3	-	13	1622	c.1573C>T	c.(1573-1575)CCG>TCG	p.P525S	PFN3_uc003mgl.2_5'Flank|F12_uc011dfy.1_Silent_p.Y55Y|F12_uc003mgn.3_Silent_p.Y55Y|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	525	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGAGGAACGGTACCTGCGCC	0.662		NA							Hereditary_Angioedema				7	23					0	0	0	0
AGXT2L2	85007	broad.mit.edu	37	5	177649532	177649532	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:177649532C>T	uc003miz.2	-	8	1003	c.751G>A	c.(751-753)GGC>AGC	p.G251S	AGXT2L2_uc003miy.2_Intron|AGXT2L2_uc003mjc.2_Missense_Mutation_p.G210S|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_Intron|AGXT2L2_uc003mjd.1_Missense_Mutation_p.G109S	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	251						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	CGGCCAAAGCCAACCTGGATC	0.488		NA											12	45					0	0	0	0
GSTA1	2938	broad.mit.edu	37	6	52662432	52662432	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr6:52662432C>T	uc003paz.2	-	3	203	c.91G>A	c.(91-93)GAA>AAA	p.E31K		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	31	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	AATTTCTCTTCAAACTGGAAG	0.368		NA											6	43					0	0	0	0
LAMB4	22798	broad.mit.edu	37	7	107752371	107752371	+	Silent	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr7:107752371G>A	uc010ljo.1	-	4	297	c.213C>T	c.(211-213)ATC>ATT	p.I71I	LAMB4_uc003vey.2_Silent_p.I71I	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	71	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TAGAGTCACAGATGAAGCATT	0.348		NA											13	86					0	0	0	0
THAP5	168451	broad.mit.edu	37	7	108204640	108204640	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr7:108204640T>A	uc003vfm.2	-	3	1337	c.1183A>T	c.(1183-1185)ATA>TTA	p.I395L	THAP5_uc003vfl.2_Missense_Mutation_p.I353L	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	395					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						TTATTCTATATCATAGTGACT	0.328		NA											14	22					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448632	110448632	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr8:110448632G>T	uc003yne.2	+	30	3675	c.3571G>T	c.(3571-3573)GAA>TAA	p.E1191*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1191	Extracellular (Potential).|IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTTGGAAATGAAACCTGCAA	0.358		NA								HNSCC(38;0.096)			22	36					7.42e-09	1.54e-08	1	0
EIF2C2	27161	broad.mit.edu	37	8	141566084	141566084	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr8:141566084C>T	uc003yvn.2	-	10	1220	c.1180G>A	c.(1180-1182)GTC>ATC	p.V394I	EIF2C2_uc010men.2_Missense_Mutation_p.V317I|EIF2C2_uc010meo.2_Missense_Mutation_p.V394I	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	394					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			AATTCACGGACGTATGGATCT	0.562		NA											10	80					0	0	0	0
C9orf93	203238	broad.mit.edu	37	9	15920346	15920346	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:15920346C>T	uc003zmd.2	+	25	3994	c.3679C>T	c.(3679-3681)CAT>TAT	p.H1227Y	C9orf93_uc003zme.2_Missense_Mutation_p.H1142Y|C9orf93_uc011lmu.1_Missense_Mutation_p.H1235Y	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1227	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		AATGACATCTCATCGAAGTCA	0.343		NA											11	30					0	0	0	0
PRUNE2	158471	broad.mit.edu	37	9	79321541	79321541	+	Silent	SNP	A	A	G			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:79321541A>G	uc010mpk.2	-	8	5773	c.5649T>C	c.(5647-5649)TAT>TAC	p.Y1883Y	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1883					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGGATTAGTATAGTGTGTTT	0.473		NA											17	14					0	0	0	0
TLE4	7091	broad.mit.edu	37	9	82334979	82334979	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:82334979C>T	uc004ald.2	+	17	2533	c.1684C>T	c.(1684-1686)CGT>TGT	p.R562C	TLE4_uc004alc.2_Missense_Mutation_p.R537C|TLE4_uc010mpr.2_Missense_Mutation_p.R416C|TLE4_uc004ale.2_Missense_Mutation_p.R174C|TLE4_uc011lsq.1_Missense_Mutation_p.R505C|TLE4_uc010mps.2_Missense_Mutation_p.R461C|TLE4_uc004alf.2_Missense_Mutation_p.R476C	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						TAACTACATCCGTTCCTGCAG	0.463		NA											8	42					0	0	0	0
CEP110	11064	broad.mit.edu	37	9	123852644	123852644	+	Silent	SNP	G	G	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:123852644G>C	uc004bkx.1	+	2	340	c.309G>C	c.(307-309)CTG>CTC	p.L103L	CEP110_uc004bkw.2_Silent_p.L103L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	103					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						TAAAATCTCTGAACCTTTCAC	0.333		NA											10	98					0	0	0	0
FGD1	2245	broad.mit.edu	37	X	54497839	54497839	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:54497839G>A	uc004dtg.2	-	2	1123	c.389C>T	c.(388-390)CCC>CTC	p.P130L	FGD1_uc011moi.1_5'Flank	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	130	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AAGCCGCTGGGGACCTTCTGG	0.607		NA											4	14					0	0	0	0
GPR174	84636	broad.mit.edu	37	X	78426986	78426986	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:78426986C>A	uc004edg.1	+	1	518	c.482C>A	c.(481-483)ACC>AAC	p.T161N		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	161	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						AGTGATGATACCTCTGGCAAT	0.478		NA								HNSCC(63;0.18)			18	29					9.17e-09	1.9e-08	1	0
PABPC5	140886	broad.mit.edu	37	X	90690579	90690579	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:90690579G>A	uc004efg.2	+	2	443	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	1						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TCAGAGAGATGGGGAGCGGGG	0.512		NA											10	6					0	0	0	0
THOC2	57187	broad.mit.edu	37	X	122767908	122767908	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:122767908T>C	uc004etu.2	-	20	2064	c.2032A>G	c.(2032-2034)ATA>GTA	p.I678V	THOC2_uc011muh.1_Missense_Mutation_p.I603V	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	678					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TCTTTCAATATAAGCAGGTCA	0.323		NA											11	49					0	0	0	0
GPC3	2719	broad.mit.edu	37	X	132888182	132888182	+	Missense_Mutation	SNP	C	C	T	rs148021273	byFrequency	TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:132888182C>T	uc004exe.1	-	3	549	c.359G>A	c.(358-360)CGC>CAC	p.R120H	GPC3_uc004exd.1_5'UTR|GPC3_uc010nrn.1_Missense_Mutation_p.R120H|GPC3_uc011mvh.1_Missense_Mutation_p.R104H|GPC3_uc010nro.1_Missense_Mutation_p.R66H|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	120						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CTTGGCATGGCGAACAACAAT	0.363		NA	T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				7	72					0	0	0	0
PLAC1	10761	broad.mit.edu	37	X	133700419	133700419	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:133700419T>C	uc004exo.1	-	3	580	c.294A>G	c.(292-294)ATA>ATG	p.I98M	PLAC1_uc004exp.1_Missense_Mutation_p.I98M	NM_021796	NP_068568	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1 precursor	98					placenta development	extracellular region				pancreas(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AAGAGTAGTGTATCTCAGTGC	0.522		NA											80	22					0	0	0	0
RIPK4	54101	broad.mit.edu	37	21	43161792	43161803	+	In_Frame_Del	DEL	GTGTGCTAGACT	GTGTGCTAGACT	-	rs148559295		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr21:43161792_43161803delGTGTGCTAGACT	uc002yzn.1	-	8	1598_1609	c.1550_1561delAGTCTAGCACAC	c.(1549-1563)GAGTCTAGCACACGG>GGG	p.517_521ESSTR>G		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	517_521						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						AACAGCAGCCGTGTGCTAGACTCGTCCCCGTT	0.632		NA											12	27	---	---	---	---	NA	NA	NA	NA
PEX2	5828	broad.mit.edu	37	8	77895656	77895657	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr8:77895656_77895657insA	uc003yax.2	-	4	1216_1217	c.758_759insT	c.(757-759)ATGfs	p.M253fs	PEX2_uc003yay.2_Frame_Shift_Ins_p.M253fs|PEX2_uc003yaz.2_Frame_Shift_Ins_p.M253fs	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	253	RING-type.				peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						TGGTGTGAGGCATGGTGGGCCA	0.436		NA											51	72	---	---	---	---	NA	NA	NA	NA