Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
GNB1	2782	broad.mit.edu	37	1	1720641	1720641	+	Missense_Mutation	SNP	C	C	T	rs11554059		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:1720641C>T	uc001aif.2	-	10	1099	c.767G>A	c.(766-768)CGT>CAT	p.R256H	GNB1_uc009vky.2_Missense_Mutation_p.R156H	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	256					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		CTGGTCAGCACGAAGGTCAAA	0.522		NA									OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	30					0	0	0	0
GRIK3	2899	broad.mit.edu	37	1	37271718	37271718	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:37271718G>A	uc001caz.2	-	14	2436	c.2301C>T	c.(2299-2301)ATC>ATT	p.I767I	GRIK3_uc001cba.1_Silent_p.I767I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	767	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGGCGTGCCGATGCCGTAGC	0.662		NA											13	53					0	0	0	0
C1orf109	54955	broad.mit.edu	37	1	38152075	38152075	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:38152075C>T	uc001cbp.2	-	3	515	c.325G>A	c.(325-327)GTG>ATG	p.V109M	C1orf109_uc001cbn.2_5'Flank|C1orf109_uc010oig.1_Missense_Mutation_p.V172M|C1orf109_uc001cbo.2_Missense_Mutation_p.V171M|C1orf109_uc001cbq.1_Silent_p.E91E	NM_017850	NP_060320	Q9NX04	CA109_HUMAN	hypothetical protein LOC54955	109											0		Myeloproliferative disorder(586;0.0393)				ATCTGAAACACTCGCTCCACA	0.498		NA											5	38					0	0	0	0
GLIS1	148979	broad.mit.edu	37	1	54060170	54060170	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:54060170G>A	uc001cvr.1	-	3	973	c.406C>T	c.(406-408)CTT>TTT	p.L136F		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	136					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						CAGGCTTCAAGTTGCAAGCTG	0.667		NA											12	42					0	0	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999913	112999913	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:112999913C>T	uc001ebx.2	+	6	2027	c.1799C>T	c.(1798-1800)ACC>ATC	p.T600I	CTTNBP2NL_uc001ebz.2_RNA	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	600						actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTCCATTGACCAAAACTCAT	0.522		NA											10	79					0	0	0	0
AQP10	89872	broad.mit.edu	37	1	154295468	154295468	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:154295468G>A	uc001feu.2	+	3	283	c.243G>A	c.(241-243)CTG>CTA	p.L81L	AQP10_uc001fev.2_Silent_p.L81L|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	81	Cytoplasmic (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGCCCACCTGAATCCAGCCT	0.363		NA											25	74					0	0	0	0
LAMC1	3915	broad.mit.edu	37	1	183085957	183085957	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:183085957T>A	uc001gpy.3	+	8	1740	c.1483T>A	c.(1483-1485)TGC>AGC	p.C495S		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	495	Laminin EGF-like 5; first part.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGCACACCCTGCTTCTGCTT	0.388		NA											18	73					0	0	0	0
RGS21	431704	broad.mit.edu	37	1	192335209	192335209	+	Silent	SNP	T	T	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:192335209T>C	uc001gsh.2	+	5	588	c.414T>C	c.(412-414)AAT>AAC	p.N138N		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	138					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						AACTGGTAAATAGCCAACAGG	0.333		NA											13	46					0	0	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213414331	213414331	+	Silent	SNP	A	A	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:213414331A>C	uc010ptr.1	+	11	1671	c.1512A>C	c.(1510-1512)TCA>TCC	p.S504S	RPS6KC1_uc001hkd.2_Silent_p.S492S|RPS6KC1_uc010pts.1_Silent_p.S292S|RPS6KC1_uc010ptt.1_Silent_p.S292S|RPS6KC1_uc010ptu.1_Silent_p.S323S|RPS6KC1_uc010ptv.1_Silent_p.S39S|RPS6KC1_uc001hke.2_Silent_p.S323S	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	504					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GTTCAAGTTCAGAAGAAGAAT	0.408		NA											15	35					0	0	0	0
ITGB1	3688	broad.mit.edu	37	10	33211200	33211200	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:33211200G>C	uc001iws.3	-	9	1249	c.1113C>G	c.(1111-1113)ATC>ATG	p.I371M	ITGB1_uc001iwp.3_Missense_Mutation_p.I371M|ITGB1_uc001iwq.3_Missense_Mutation_p.I371M|ITGB1_uc001iwr.3_Missense_Mutation_p.I371M|ITGB1_uc001iwt.3_Missense_Mutation_p.I371M|ITGB1_uc001iwu.1_Missense_Mutation_p.I371M	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	371	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ATGCATCAATGATCAACTGAA	0.328		NA											19	79					0	0	0	0
ZNF33B	7582	broad.mit.edu	37	10	43090020	43090020	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:43090020A>T	uc001jaf.1	-	5	493	c.378T>A	c.(376-378)TTT>TTA	p.F126L	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.F14L|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	126						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGTCCATGTTAAATGGTATTC	0.348		NA											11	66					0	0	0	0
PHYHIPL	84457	broad.mit.edu	37	10	61005100	61005100	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:61005100G>T	uc001jkk.3	+	5	1146	c.880G>T	c.(880-882)GAA>TAA	p.E294*	PHYHIPL_uc001jkl.3_Nonsense_Mutation_p.E248*|PHYHIPL_uc001jkm.3_Nonsense_Mutation_p.E268*	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	294											0						ACCAGGAGATGAATTTTGTAA	0.403		NA											19	55					9.96e-16	5.46e-15	1	0
INPP5F	22876	broad.mit.edu	37	10	121582640	121582640	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:121582640G>C	uc001leo.2	+	18	2256	c.2090G>C	c.(2089-2091)AGA>ACA	p.R697T	INPP5F_uc001lep.2_Missense_Mutation_p.R87T	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	697							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CTGCACTACAGATACAAAGAA	0.403		NA											3	58					0	0	0	0
OR51I2	390064	broad.mit.edu	37	11	5475541	5475541	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:5475541C>A	uc010qzf.1	+	1	823	c.823C>A	c.(823-825)CTC>ATC	p.L275I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATACATGTCCTCATGTCAAA	0.473		NA											47	158					1.24e-20	6.83e-20	1	0
SLC1A2	6506	broad.mit.edu	37	11	35308365	35308365	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:35308365C>T	uc001mwd.2	-	8	1817	c.1225G>A	c.(1225-1227)GCC>ACC	p.A409T	SLC1A2_uc001mwe.2_Missense_Mutation_p.A400T|SLC1A2_uc010rev.1_Missense_Mutation_p.A409T	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	409	Helical; (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	ATAAAGATGGCGGCTACCGCT	0.468		NA											17	141					0	0	0	0
OR5D18	219438	broad.mit.edu	37	11	55587492	55587492	+	Silent	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:55587492C>T	uc010rin.1	+	1	387	c.387C>T	c.(385-387)AAC>AAT	p.N129N		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CCATTTGCAACCCTCTGCTCT	0.478		NA											44	159					0	0	0	0
OR4D6	219983	broad.mit.edu	37	11	59225310	59225310	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:59225310G>A	uc010rku.1	+	1	877	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGAAATCAAGAGATGAAGTC	0.522		NA											44	117					0	0	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120291479	120291479	+	Missense_Mutation	SNP	G	G	A	rs34754222		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:120291479G>A	uc001pxl.1	+	5	224	c.217G>A	c.(217-219)GTA>ATA	p.V73I	ARHGEF12_uc009zat.2_Missense_Mutation_p.V54I|ARHGEF12_uc010rzn.1_5'UTR|ARHGEF12_uc009zau.1_5'UTR	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	73	PDZ.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TCAGCGTTGCGTAATCATCCA	0.383		NA	T	MLL	AML								23	48					0	0	0	0
ACRBP	84519	broad.mit.edu	37	12	6749669	6749669	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:6749669C>T	uc001qpu.1	-	7	1145	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	LPAR5_uc010sff.1_5'Flank|ACRBP_uc001qpt.1_5'Flank|ACRBP_uc010sfg.1_Missense_Mutation_p.R333Q	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	366						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CATGTGTCGCCGCCCAAGGCT	0.637		NA											8	23					0	0	0	0
CLEC12B	387837	broad.mit.edu	37	12	10167883	10167883	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:10167883C>T	uc001qwz.2	+	4	570	c.442C>T	c.(442-444)CAA>TAA	p.Q148*	CLEC12B_uc001qwx.1_Nonsense_Mutation_p.Q148*|CLEC12B_uc001qwy.1_Nonsense_Mutation_p.Q45*|CLEC12B_uc009zhe.2_RNA	NM_001129998	NP_001123470	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B isoform	148	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity|sugar binding				0						TAAGATGTGGCAATGGTACCA	0.388		NA											23	94					0	0	0	0
PTPRO	5800	broad.mit.edu	37	12	15742441	15742441	+	Missense_Mutation	SNP	C	C	T	rs61757814		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:15742441C>T	uc001rcv.1	+	25	3637	c.3463C>T	c.(3463-3465)CAC>TAC	p.H1155Y	PTPRO_uc001rcw.1_Missense_Mutation_p.H1127Y|PTPRO_uc001rcx.1_Missense_Mutation_p.H344Y|PTPRO_uc001rcy.1_Missense_Mutation_p.H344Y|PTPRO_uc001rcz.1_Missense_Mutation_p.H316Y|PTPRO_uc001rda.1_Missense_Mutation_p.H316Y	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1155	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GCTCTTGCAGCACATTCGGGA	0.463		NA											29	77					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	21981956	21981956	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:21981956G>A	uc001rfi.1	-	29	3625	c.3605C>T	c.(3604-3606)ACG>ATG	p.T1202M	ABCC9_uc001rfh.2_Missense_Mutation_p.T1202M|ABCC9_uc001rfj.1_Missense_Mutation_p.T1166M	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1202	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTTTGTATCCGTCAGTTCCAG	0.413		NA											19	95					0	0	0	0
DENND5B	160518	broad.mit.edu	37	12	31552693	31552693	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:31552693C>T	uc001rki.1	-	16	3149	c.2963G>A	c.(2962-2964)GGG>GAG	p.G988E	DENND5B_uc001rkh.1_Missense_Mutation_p.G1023E|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	988	PLAT.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GGTCAGCTTCCCCAAGTTCTG	0.443		NA											5	33					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53671305	53671305	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:53671305G>A	uc001sck.2	+	10	2228	c.2137G>A	c.(2137-2139)GAA>AAA	p.E713K	ESPL1_uc001scj.2_Missense_Mutation_p.E388K|ESPL1_uc010soe.1_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	713					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGAGGAATTTGAAGTCAATGA	0.433		NA											16	38					0	0	0	0
PDE1B	5153	broad.mit.edu	37	12	54968993	54968993	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:54968993C>G	uc001sgd.1	+	11	1342	c.1176C>G	c.(1174-1176)TTC>TTG	p.F392L	PDE1B_uc010soz.1_Missense_Mutation_p.F255L|PDE1B_uc010spa.1_Missense_Mutation_p.F351L|PDE1B_uc001sgf.2_Missense_Mutation_p.F255L|PDE1B_uc001sge.2_Missense_Mutation_p.F372L|PDE1B_uc009znq.2_Missense_Mutation_p.F188L	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	392	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGAGGAATTCTTCCGTCAGG	0.577		NA											27	85					0	0	0	0
CDK4	1019	broad.mit.edu	37	12	58143273	58143273	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:58143273C>T	uc001spv.2	-	6	874	c.647G>A	c.(646-648)GGA>GAA	p.G216E	CDK4_uc010ssb.1_Missense_Mutation_p.G96E|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	216	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TTCAGAGTTTCCACAGAAGAG	0.418		NA	Mis			melanoma 			Hereditary_Melanoma				6	29					0	0	0	0
SYT1	6857	broad.mit.edu	37	12	79685859	79685859	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:79685859G>T	uc001sys.2	+	7	1094	c.423G>T	c.(421-423)GAG>GAT	p.E141D	SYT1_uc001syt.2_Missense_Mutation_p.E141D|SYT1_uc001syu.2_Missense_Mutation_p.E138D|SYT1_uc001syv.2_Missense_Mutation_p.E141D	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	141	Cytoplasmic (Potential).|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AAGAAGAGGAGAAACTGGGAA	0.368		NA											10	37					7.48e-07	3.85e-06	1	0
PSPC1	55269	broad.mit.edu	37	13	20325582	20325582	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr13:20325582C>A	uc001uml.2	-	4	982	c.796G>T	c.(796-798)GCT>TCT	p.A266S	PSPC1_uc001umj.1_RNA|PSPC1_uc001umk.1_RNA	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	266	Sufficient for perinucleolar caps localization and interaction with NONO.|Sufficient for paraspeckles localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		CCAGGTTGAGCAAAACGTGGT	0.378		NA											12	41					0.000978159	0.00469724	1	0
ATP7B	540	broad.mit.edu	37	13	52542595	52542595	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr13:52542595G>A	uc001vfw.2	-	4	1849	c.1692C>T	c.(1690-1692)GGC>GGT	p.G564G	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Silent_p.G564G|ATP7B_uc001vfy.2_Silent_p.G453G|ATP7B_uc010tgt.1_Silent_p.G564G|ATP7B_uc010tgu.1_Silent_p.G564G|ATP7B_uc010tgv.1_Silent_p.G564G|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	564	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GCTCAATGTTGCCATCGGAGC	0.498		NA							Wilson_disease				8	39					0	0	0	0
DACH1	1602	broad.mit.edu	37	13	72053410	72053410	+	Silent	SNP	T	T	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr13:72053410T>C	uc010thn.1	-	9	2184	c.1761A>G	c.(1759-1761)CAA>CAG	p.Q587Q	DACH1_uc010tho.1_Silent_p.Q439Q|DACH1_uc010thp.1_Silent_p.Q385Q	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	639	DACHbox-C.|Potential.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CCTGTTTCTCTTGAGCTCTGG	0.373		NA											20	86					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23886750	23886750	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:23886750C>T	uc001wjx.2	-	31	4421	c.4315G>A	c.(4315-4317)GCT>ACT	p.A1439T		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1439	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGGGCTGCAGCAGCAGCATTG	0.602		NA											17	86					0	0	0	0
PRKD1	5587	broad.mit.edu	37	14	30135410	30135410	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:30135410G>A	uc001wqh.2	-	3	589	c.408C>T	c.(406-408)TCC>TCT	p.S136S		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	136					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CAAAGGTGGCGGAAGCTGTAA	0.403		NA											19	52					0	0	0	0
FBXO34	55030	broad.mit.edu	37	14	55818744	55818744	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:55818744G>C	uc001xbu.2	+	2	1881	c.1636G>C	c.(1636-1638)GAG>CAG	p.E546Q	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.E546Q	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	546										ovary(2)|lung(2)|skin(1)	5						ACCAGTGCTTGAGGCATCCAG	0.507		NA											41	122					0	0	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68215205	68215205	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:68215205C>T	uc001xka.2	-	42	7707	c.7568G>A	c.(7567-7569)TGG>TAG	p.W2523*	ZFYVE26_uc010tsz.1_RNA	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2523					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGTCAGAAGCCACTGGGCACA	0.642		NA											4	64					0	0	0	0
CPSF2	53981	broad.mit.edu	37	14	92601740	92601740	+	Silent	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:92601740C>T	uc001yah.1	+	6	682	c.445C>T	c.(445-447)CTG>TTG	p.L149L		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	149					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TATCACACCTCTGCCAGCTGG	0.368		NA											14	57					0	0	0	0
C14orf73	91828	broad.mit.edu	37	14	103573994	103573994	+	Silent	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:103573994C>T	uc001ymk.2	+	9	1804	c.1728C>T	c.(1726-1728)TTC>TTT	p.F576F		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	576											0		Melanoma(154;0.155)	Epithelial(46;0.221)			TGCACCGGTTCGTGGTCCGCG	0.612		NA											4	7					0	0	0	0
SHC4	399694	broad.mit.edu	37	15	49127202	49127202	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:49127202G>A	uc001zxb.1	-	11	1930	c.1501C>T	c.(1501-1503)CAG>TAG	p.Q501*	SHC4_uc010uey.1_Nonsense_Mutation_p.Q258*|SHC4_uc010uez.1_Nonsense_Mutation_p.Q215*	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	501	CH1.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		GCACCCGGCTGAACAGTTTCT	0.418		NA											4	11					0	0	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49288750	49288750	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:49288750C>T	uc001zxe.1	-	17	2571	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	SECISBP2L_uc001zxd.1_Missense_Mutation_p.E768K|SECISBP2L_uc010bep.1_Missense_Mutation_p.E575K	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	813										breast(1)|skin(1)	2						TTCCTGGCCTCCTCAGTGAGT	0.368		NA											55	192					0	0	0	0
THSD4	79875	broad.mit.edu	37	15	72039251	72039251	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:72039251G>T	uc002atb.1	+	12	2190	c.2111G>T	c.(2110-2112)CGC>CTC	p.R704L	THSD4_uc002ate.2_Missense_Mutation_p.R344L	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	704	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GTTCTGTGCCGCCAGGTGTAC	0.627		NA											13	27					1.36e-06	6.98e-06	1	0
CHSY1	22856	broad.mit.edu	37	15	101719133	101719133	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:101719133C>G	uc002bwt.1	-	4	1352	c.869G>C	c.(868-870)AGA>ACA	p.R290T	CHSY1_uc010usd.1_Missense_Mutation_p.R18T	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	290	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATGGAGATCTCTAATGTACCC	0.398		NA											13	57					0	0	0	0
ABCA3	21	broad.mit.edu	37	16	2347779	2347779	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:2347779G>A	uc002cpy.1	-	16	2752	c.2040C>T	c.(2038-2040)ATC>ATT	p.I680I	ABCA3_uc010bsk.1_Silent_p.I622I|ABCA3_uc010bsl.1_Silent_p.I680I	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	680	ABC transporter 1.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TGGAGCCTGCGATGAGGGCGA	0.662		NA											10	54					0	0	0	0
ZNF174	7727	broad.mit.edu	37	16	3452371	3452371	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:3452371G>T	uc002cvc.2	+	1	1182	c.367G>T	c.(367-369)GAT>TAT	p.D123Y	ZNF434_uc002cux.3_5'Flank|ZNF434_uc010uwx.1_5'Flank|ZNF434_uc002cuy.3_5'Flank|ZNF434_uc002cuz.2_5'Flank|ZNF434_uc010uwy.1_5'Flank|ZNF434_uc010uxa.1_5'Flank|ZNF174_uc002cva.2_Missense_Mutation_p.D123Y|ZNF174_uc002cvb.2_Missense_Mutation_p.D123Y	NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	123	SCAN box.				negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0						CCTCGTGGAAGATTTTCACAG	0.468		NA											20	50					1.56e-14	8.47e-14	1	0
CREBBP	1387	broad.mit.edu	37	16	3778424	3778424	+	Silent	SNP	T	T	C	rs142545779	byFrequency	TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:3778424T>C	uc002cvv.2	-	31	6828	c.6624A>G	c.(6622-6624)CAA>CAG	p.Q2208Q	CREBBP_uc002cvw.2_Silent_p.Q2170Q	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2208	Poly-Gln.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.Q2208H(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		gttgctgctgttgttgctgct	0.428		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				6	32					0	0	0	0
NOD2	64127	broad.mit.edu	37	16	50745602	50745602	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:50745602G>A	uc002egm.1	+	4	1885	c.1780G>A	c.(1780-1782)GGG>AGG	p.G594R	NOD2_uc010cbk.1_Missense_Mutation_p.G567R|NOD2_uc002egl.1_Missense_Mutation_p.G372R|NOD2_uc010cbl.1_Missense_Mutation_p.G372R|NOD2_uc010cbm.1_Missense_Mutation_p.G372R|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	594	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				TGTCGTGCCAGGGAGTACGGC	0.577		NA											10	26					0	0	0	0
RBL2	5934	broad.mit.edu	37	16	53524139	53524139	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:53524139G>C	uc002ehi.3	+	22	3465	c.3347G>C	c.(3346-3348)AGA>ACA	p.R1116T	RBL2_uc002ehj.2_Missense_Mutation_p.R826T|RBL2_uc010vgw.1_Missense_Mutation_p.R495T	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1116					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CCTGCAAAAAGAATTTGCCCA	0.393		NA											21	49					0	0	0	0
GOT2	2806	broad.mit.edu	37	16	58743428	58743428	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:58743428G>A	uc002eof.1	-	9	1177	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	GOT2_uc010vim.1_Missense_Mutation_p.R312W	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	355					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGTTGAGTCCGCATGCCAATG	0.507		NA											7	282					0	0	0	0
SLC38A8	146167	broad.mit.edu	37	16	84065527	84065527	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:84065527C>T	uc002fhg.1	-	4	577	c.577G>A	c.(577-579)GTG>ATG	p.V193M		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	193	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						TAGTACTGCACGGTGATGACC	0.617		NA											15	55					0	0	0	0
OR1E2	8388	broad.mit.edu	37	17	3336564	3336564	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:3336564G>T	uc010vre.1	-	1	572	c.572C>A	c.(571-573)TCT>TAT	p.S191Y		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	191	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						CAGCAGAGCAGACATATCACA	0.468		NA											18	27					4.76e-15	2.6e-14	1	0
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	rs121912651		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	44					0	0	0	0
PER1	5187	broad.mit.edu	37	17	8053316	8053316	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:8053316C>T	uc002gkd.2	-	4	740	c.502G>A	c.(502-504)GCA>ACA	p.A168T	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Missense_Mutation_p.A152T|PER1_uc010vus.1_Missense_Mutation_p.A168T	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	168					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CAGGCCAGTGCGTACTGCAGC	0.627		NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					41	102					0	0	0	0
TEKT3	64518	broad.mit.edu	37	17	15215733	15215733	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:15215733C>A	uc002gon.2	-	7	1131	c.944G>T	c.(943-945)CGG>CTG	p.R315L		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	315					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		GGAAGCTGCCCGTTCACTCTG	0.458		NA											20	57					1.34e-09	7.1e-09	1	0
TEKT3	64518	broad.mit.edu	37	17	15234646	15234646	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:15234646T>C	uc002gon.2	-	3	444	c.257A>G	c.(256-258)AAC>AGC	p.N86S		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	86					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		AGTGGTTCTGTTGGAAACAAA	0.478		NA											31	67					0	0	0	0
KRT37	8688	broad.mit.edu	37	17	39580482	39580482	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:39580482G>A	uc002hwp.1	-	1	341	c.294C>T	c.(292-294)AAC>AAT	p.N98N	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	98	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CATTCAGGGTGTTTTTGCCGT	0.582		NA											21	68					0	0	0	0
KRT35	3886	broad.mit.edu	37	17	39635675	39635675	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:39635675A>C	uc002hws.2	-	3	678	c.635T>G	c.(634-636)CTG>CGG	p.L212R		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	212	Rod.|Coil 1B.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				AGACTTGCACAGGGTCAGGTC	0.517		NA											18	82					0	0	0	0
WNT3	7473	broad.mit.edu	37	17	44845801	44845801	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:44845801C>T	uc002ikv.2	-	4	1072	c.953G>A	c.(952-954)GGC>GAC	p.G318D		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	318					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			CGTGTTGTGGCCCCGGCCACA	0.592		NA											31	117					0	0	0	0
QRICH2	84074	broad.mit.edu	37	17	74289852	74289852	+	Missense_Mutation	SNP	C	C	T	rs138229886		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:74289852C>T	uc002jrd.1	-	4	638	c.458G>A	c.(457-459)CGT>CAT	p.R153H	QRICH2_uc010wsz.1_Missense_Mutation_p.R79H|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	153							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						AGCTTCATCACGGGCCCTCGG	0.542		NA											14	50					0	0	0	0
ATP8B3	148229	broad.mit.edu	37	19	1796851	1796851	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:1796851C>T	uc002ltw.2	-	16	1846	c.1612G>A	c.(1612-1614)GCC>ACC	p.A538T	ATP8B3_uc002ltv.2_Missense_Mutation_p.A491T|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	538	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCCCGTCGGCGAACTTGTTC	0.721		NA											7	20					0	0	0	0
PRKACA	5566	broad.mit.edu	37	19	14213716	14213716	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:14213716A>G	uc002myc.2	-	4	448	c.248T>C	c.(247-249)CTG>CCG	p.L83P	PRKACA_uc002myb.2_Missense_Mutation_p.L75P|PRKACA_uc010xnm.1_Missense_Mutation_p.L25P|PRKACA_uc002myd.2_Missense_Mutation_p.L25P	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	83	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						GATCTGTTTCAGTTTCACCAC	0.562		NA											23	81					0	0	0	0
CYP4F12	66002	broad.mit.edu	37	19	15806808	15806808	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:15806808C>T	uc002nbl.2	+	10	1239	c.1178C>T	c.(1177-1179)CCC>CTC	p.P393L		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AGGTTACATCCCCCAGCTCCC	0.597		NA											27	61					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22156897	22156897	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:22156897G>T	uc002nqp.2	-	4	1088	c.939C>A	c.(937-939)TAC>TAA	p.Y313*	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTTACATTTGTAGGGCTTCT	0.418		NA											9	48					2.18e-05	0.00010967	1	0
SLC7A9	11136	broad.mit.edu	37	19	33334841	33334841	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:33334841C>T	uc002ntv.3	-	10	1111	c.994G>A	c.(994-996)GGC>AGC	p.G332S	SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Missense_Mutation_p.G332S|SLC7A9_uc002ntw.3_Missense_Mutation_p.G123S	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	332	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CCCTCCCGGCCCGCCACGTAA	0.567		NA											7	28					0	0	0	0
KIAA0355	9710	broad.mit.edu	37	19	34791871	34791871	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:34791871G>A	uc002nvd.3	+	2	1352	c.493G>A	c.(493-495)GAG>AAG	p.E165K	KIAA0355_uc010edk.1_Missense_Mutation_p.E155K	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	165										ovary(1)	1	Esophageal squamous(110;0.162)					CCAGGACATTGAGGTAGAGTA	0.393		NA											10	43					0	0	0	0
HNRNPL	3191	broad.mit.edu	37	19	39334716	39334716	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:39334716C>G	uc010xul.1	-	5	750	c.739G>C	c.(739-741)GCC>CCC	p.A247P	HNRNPL_uc002ojk.2_5'Flank|HNRNPL_uc002ojl.2_5'Flank|HNRNPL_uc010xum.1_Missense_Mutation_p.A114P|HNRNPL_uc010xun.1_5'UTR	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	247	RRM 2.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GAGGCCTTGGCCCGCTGGGCA	0.493		NA											20	65					0	0	0	0
PSG1	5669	broad.mit.edu	37	19	43382154	43382155	+	Missense_Mutation	DNP	CG	CG	AT	rs142473373		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:43382154_43382155CG>AT	uc002ovb.2	-	2	478_479	c.340_341CG>AT	c.(340-342)CGG>ATG	p.R114M	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.R114M|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.R114M|PSG1_uc010eio.1_Missense_Mutation_p.R114M|PSG1_uc002oux.1_Missense_Mutation_p.R43M|PSG1_uc002ouy.1_Missense_Mutation_p.R114M|PSG1_uc002ouz.1_Missense_Mutation_p.R114M|PSG1_uc002ova.1_Missense_Mutation_p.R114M|PSG1_uc002ovc.2_Missense_Mutation_p.R114M|PSG1_uc002ovd.1_Missense_Mutation_p.R114M	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	114	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGCGTCCTCCCGGGTGACATTC	0.45		NA											9	397					0	0	0	0
PRR12	57479	broad.mit.edu	37	19	50102549	50102549	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:50102549G>A	uc002poo.3	+	5	3699	c.3699G>A	c.(3697-3699)AAG>AAA	p.K1233K		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	412	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CTGTGCCCAAGGCTGGCGAGG	0.617		NA											6	22					0	0	0	0
USP29	57663	broad.mit.edu	37	19	57642405	57642405	+	Missense_Mutation	SNP	G	G	T	rs148519716		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:57642405G>T	uc002qny.2	+	4	2718	c.2362G>T	c.(2362-2364)GGT>TGT	p.G788C		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	788					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGGGGCACTGGGTTCTGACAA	0.458		NA											14	31					3.27e-08	1.7e-07	1	0
ALLC	55821	broad.mit.edu	37	2	3726069	3726069	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:3726069G>A	uc010ewt.2	+	4	257	c.96G>A	c.(94-96)CCG>CCA	p.P32P		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	51							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		GTGACAGCCCGTGCTTCAAAG	0.488		NA								HNSCC(21;0.051)			7	30					0	0	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43953472	43953472	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:43953472A>T	uc010yny.1	+	17	2686	c.2603A>T	c.(2602-2604)GAT>GTT	p.D868V	PLEKHH2_uc002rtf.3_Missense_Mutation_p.D867V	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	868	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGATCTTGTGATTCAGATGAA	0.388		NA											10	44					0	0	0	0
GPR45	11250	broad.mit.edu	37	2	105858505	105858505	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:105858505G>T	uc002tco.1	+	1	306	c.190G>T	c.(190-192)GCT>TCT	p.A64S		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	64	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CCAGAGGCCGGCTATGCGCTC	0.617		NA											33	104					1.56e-22	8.71e-22	1	0
HECW2	57520	broad.mit.edu	37	2	197183717	197183717	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:197183717C>T	uc002utm.1	-	9	2080	c.1897G>A	c.(1897-1899)GAG>AAG	p.E633K	HECW2_uc002utl.1_Missense_Mutation_p.E277K	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	633					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CTCTCTCCCTCAGGCCTGGTG	0.592		NA											13	31					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202150039	202150039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:202150039C>T	uc002uxr.1	+	9	1512	c.1303C>T	c.(1303-1305)CGA>TGA	p.R435*	CASP8_uc002uxp.1_Nonsense_Mutation_p.R452*|CASP8_uc002uxq.1_Nonsense_Mutation_p.R420*|CASP8_uc002uxt.1_Nonsense_Mutation_p.R494*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.R420*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.R351*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	435					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCGATGTCCTCGGTAAGTTTT	0.502		NA								HNSCC(4;0.00038)			15	54					0	0	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169470	207169470	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:207169470C>A	uc002vbp.2	+	5	468	c.218C>A	c.(217-219)ACT>AAT	p.T73N		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	73							nucleic acid binding|zinc ion binding			ovary(3)	3						CATGTGAATACTGGGTCATCG	0.383		NA											22	39					2.22e-12	1.19e-11	1	0
OBSL1	23363	broad.mit.edu	37	2	220419305	220419305	+	Silent	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:220419305C>T	uc010fwk.2	-	15	4824	c.4767G>A	c.(4765-4767)TCG>TCA	p.S1589S		NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1589					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GGTGGCCGTCCGAGTGGATGT	0.642		NA											7	20					0	0	0	0
THAP4	51078	broad.mit.edu	37	2	242573331	242573331	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:242573331C>T	uc002wbt.2	-	2	464	c.241G>A	c.(241-243)GTG>ATG	p.V81M		NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	81	THAP-type.						DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		ATGGATGGCACGGCCGTGGGC	0.587		NA											36	123					0	0	0	0
SLC4A11	83959	broad.mit.edu	37	20	3208447	3208447	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr20:3208447C>T	uc002wig.2	-	19	2710	c.2662G>A	c.(2662-2664)GAG>AAG	p.E888K	SLC4A11_uc010zqe.1_Missense_Mutation_p.E915K|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.E872K	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	888	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GGCCTGTGCTCAGCGTCCATG	0.612		NA											11	38					0	0	0	0
MYH9	4627	broad.mit.edu	37	22	36688143	36688144	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr22:36688143_36688144CA>AG	uc003apg.2	-	31	4463_4464	c.4232_4233TG>CT	c.(4231-4233)CTG>CCT	p.L1411P		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1411	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGTCTTCTCCAGCTTGTCGTA	0.634		NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				9	75					0	0	0	0
CACNG2	10369	broad.mit.edu	37	22	37098538	37098538	+	Silent	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr22:37098538C>A	uc003aps.1	-	1	366	c.84G>T	c.(82-84)GTG>GTT	p.V28V	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	28	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						AGTCGGTTCCCACAGCTATGG	0.453		NA											43	146					1.22e-19	6.72e-19	1	0
MEI1	150365	broad.mit.edu	37	22	42189908	42189908	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr22:42189908G>C	uc003baz.1	+	27	3446	c.3421G>C	c.(3421-3423)GAC>CAC	p.D1141H	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.D527H|MEI1_uc003bbc.1_Missense_Mutation_p.D509H|MEI1_uc010gym.1_Missense_Mutation_p.D474H|MEI1_uc003bbd.1_Missense_Mutation_p.D384H|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA|MEI1_uc011apf.1_Missense_Mutation_p.D155H|MEI1_uc010gyo.1_3'UTR|MEI1_uc003bbf.2_Missense_Mutation_p.D155H|MEI1_uc003bbg.2_Missense_Mutation_p.D155H	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	1141							binding			central_nervous_system(1)|skin(1)	2						CCGGAGCCCAGACATTGGTAG	0.498		NA											5	13					0	0	0	0
FLNB	2317	broad.mit.edu	37	3	58120482	58120482	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr3:58120482C>G	uc003djj.2	+	27	4819	c.4654C>G	c.(4654-4656)CTT>GTT	p.L1552V	FLNB_uc010hne.2_Missense_Mutation_p.L1583V|FLNB_uc003djk.2_Missense_Mutation_p.L1552V|FLNB_uc010hnf.2_Missense_Mutation_p.L1552V|FLNB_uc003djl.2_Missense_Mutation_p.L1383V|FLNB_uc003djm.2_Missense_Mutation_p.L1383V	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1552	Filamin 14.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGAAGGCCTGCTTGCTGTTCA	0.473		NA											43	132					0	0	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377777	113377777	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr3:113377777G>A	uc003eam.2	-	7	3163	c.2752C>T	c.(2752-2754)CAA>TAA	p.Q918*	KIAA2018_uc003eal.2_Nonsense_Mutation_p.Q862*	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	918					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GATGTCTCTTGTTGTAGATTA	0.448		NA											33	98					0	0	0	0
EIF2B5	8893	broad.mit.edu	37	3	183858377	183858377	+	Silent	SNP	C	C	A	rs113994068		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr3:183858377C>A	uc003fmp.2	+	7	1379	c.1015C>A	c.(1015-1017)CGG>AGG	p.R339R	EIF2B5_uc003fmq.2_Silent_p.R60R|EIF2B5_uc003fmr.2_5'Flank	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	339			R -> Q (in VWM).|R -> W (in VWM).|R -> P (in VWM).		astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CACTCATTCCCGGCACAACAT	0.587		NA											5	112					0.00116845	0.00555216	1	0
UGT2B10	7365	broad.mit.edu	37	4	69682402	69682402	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr4:69682402G>C	uc003hee.2	+	1	690	c.665G>C	c.(664-666)TGG>TCG	p.W222S	UGT2B10_uc011cam.1_Intron	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	222					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTTGACTTTTGGTTCCAAATA	0.313		NA											17	65					0	0	0	0
FBXO8	26269	broad.mit.edu	37	4	175158632	175158632	+	Missense_Mutation	SNP	T	T	A	rs148818503		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr4:175158632T>A	uc003itp.2	-	6	1741	c.891A>T	c.(889-891)CAA>CAT	p.Q297H	FBXO8_uc003itq.2_Missense_Mutation_p.Q256H	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	297					regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		CACTAATATTTTGAGCAGCGC	0.378		NA											19	58					0	0	0	0
IRF2	3660	broad.mit.edu	37	4	185339790	185339790	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr4:185339790G>A	uc003iwf.3	-	4	460	c.260C>T	c.(259-261)TCC>TTC	p.S87F		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	87	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		ATCAGGCAAGGAATTCATGGC	0.408		NA											8	36					0	0	0	0
CDH12	1010	broad.mit.edu	37	5	21817158	21817158	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:21817158G>T	uc010iuc.2	-	6	1356	c.898C>A	c.(898-900)CAA>AAA	p.Q300K	CDH12_uc011cno.1_Missense_Mutation_p.Q260K|CDH12_uc003jgk.2_Missense_Mutation_p.Q300K	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	300	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TCTGCATTTTGTCCAAAATCA	0.388		NA								HNSCC(59;0.17)			14	87					3.27e-08	1.7e-07	1	0
TTC23L	153657	broad.mit.edu	37	5	34864544	34864544	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:34864544G>A	uc003jiu.2	+	6	642	c.539G>A	c.(538-540)GGC>GAC	p.G180D	TTC23L_uc003jiv.2_5'UTR|TTC23L_uc010iut.1_5'UTR	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	180	Potential.						binding			central_nervous_system(1)	1						TATTTCACTGGCAGAGAAGCC	0.423		NA											6	105					0	0	0	0
PLK2	10769	broad.mit.edu	37	5	57751189	57751189	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:57751189C>T	uc003jrn.2	-	12	1805	c.1678G>A	c.(1678-1680)GAT>AAT	p.D560N		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	560	POLO box 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		TCAGGAGCATCTGTTGCTGGG	0.408		NA											15	67					0	0	0	0
TTC37	9652	broad.mit.edu	37	5	94833175	94833175	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:94833175G>T	uc003klb.2	-	34	3851	c.3581C>A	c.(3580-3582)GCT>GAT	p.A1194D		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1194							binding			ovary(3)|pancreas(1)	4						AGACCAAAGAGCAGGGTCACC	0.373		NA											6	20					0.000157383	0.000774942	1	0
FSTL4	23105	broad.mit.edu	37	5	132556521	132556521	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:132556521G>A	uc003kyn.1	-	12	1595	c.1377C>T	c.(1375-1377)GAC>GAT	p.D459D	FSTL4_uc003kym.1_Silent_p.D108D	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	459						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGATACCGTCGTCGGAGAAGA	0.547		NA											19	84					0	0	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140779287	140779287	+	Silent	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:140779287C>T	uc003lkf.1	+	1	1593	c.1593C>T	c.(1591-1593)CGC>CGT	p.R531R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.R531R	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	531	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGGCCCGCGACCAGGGCT	0.662		NA											7	27					0	0	0	0
FBXO38	81545	broad.mit.edu	37	5	147819261	147819261	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:147819261C>G	uc003lpf.1	+	19	3196	c.3076C>G	c.(3076-3078)CAC>GAC	p.H1026D	FBXO38_uc003lpg.1_Missense_Mutation_p.H951D|FBXO38_uc003lph.2_Missense_Mutation_p.H781D	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	1026						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACCCCTATCACATCTGTAT	0.433		NA											16	88					0	0	0	0
WRNIP1	56897	broad.mit.edu	37	6	2779537	2779537	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:2779537G>A	uc003mtz.2	+	4	1488	c.1297G>A	c.(1297-1299)GCT>ACT	p.A433T	WRNIP1_uc003mua.2_Missense_Mutation_p.A408T	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	433					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				AGACACCCTGGCTTACCTCAG	0.532		NA											22	67					0	0	0	0
MBOAT1	154141	broad.mit.edu	37	6	20124638	20124638	+	Splice_Site	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:20124638C>T	uc003ncx.1	-	8	1112	c.907_splice	c.e8+1	p.A303_splice	MBOAT1_uc011dji.1_Splice_Site_p.A154_splice	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain						phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			ATCAAACTTACCTAATGTCCA	0.428		NA											12	45					0	0	0	0
ZNF192	7745	broad.mit.edu	37	6	28120928	28120928	+	Silent	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:28120928C>T	uc003nkn.1	+	6	1054	c.870C>T	c.(868-870)AAC>AAT	p.N290N	ZNF192_uc010jqx.1_Silent_p.N290N|ZNF192_uc010jqy.1_Silent_p.N103N|ZNF192_uc011dkz.1_Silent_p.N103N	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	290	KRAB.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCAAATGCAACGGGGATGTTA	0.493		NA											19	36					0	0	0	0
KCTD20	222658	broad.mit.edu	37	6	36449469	36449469	+	Silent	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:36449469G>C	uc003ome.2	+	6	1180	c.789G>C	c.(787-789)CTG>CTC	p.L263L	KCTD20_uc011dtm.1_Silent_p.L118L|KCTD20_uc011dtn.1_Silent_p.L17L|KCTD20_uc010jwk.2_Silent_p.L97L|KCTD20_uc011dto.1_Silent_p.L17L	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	263						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						TTGTTGTGCTGACGGATGAGG	0.507		NA											8	54					0	0	0	0
MEA1	4201	broad.mit.edu	37	6	42980233	42980233	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:42980233C>T	uc003otk.2	-	4	600	c.533G>A	c.(532-534)CGG>CAG	p.R178Q	MEA1_uc010jyc.1_Intron|KLHDC3_uc003otl.2_5'Flank|KLHDC3_uc003otm.2_5'Flank|KLHDC3_uc010jyf.2_5'Flank|KLHDC3_uc003otn.2_5'Flank	NM_014623	NP_055438	Q16626	MEA1_HUMAN	male-enhanced antigen	178					cell differentiation|male gonad development|spermatogenesis		protein binding			central_nervous_system(1)|skin(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGATGCCTGCCGGGCTTGGAG	0.582		NA											37	172					0	0	0	0
SLC35F1	222553	broad.mit.edu	37	6	118228943	118228943	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:118228943G>A	uc003pxx.3	+	1	255	c.54G>A	c.(52-54)CCG>CCA	p.P18P		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	18					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CGCCAGCCCCGCCGAACCATG	0.746		NA											14	16					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21639665	21639665	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:21639665G>T	uc003svc.2	+	15	2959	c.2928G>T	c.(2926-2928)ATG>ATT	p.M976I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	976	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TAGAAGAAATGTTATGCAATA	0.373		NA							Kartagener_syndrome				5	94					5.94e-07	3.07e-06	1	0
GTF2I	2969	broad.mit.edu	37	7	74105332	74105332	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:74105332G>A	uc003uau.2	+	3	497	c.127G>A	c.(127-129)GAA>AAA	p.E43K	GTF2I_uc003uat.2_Missense_Mutation_p.E43K|GTF2I_uc003uav.2_Missense_Mutation_p.E43K|GTF2I_uc003uaw.2_Missense_Mutation_p.E43K|GTF2I_uc003uay.2_Missense_Mutation_p.E43K|GTF2I_uc003uax.2_Missense_Mutation_p.E43K	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	43					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						GTCCAAAGCCGAAGTGGCCTG	0.408		NA											43	126					0	0	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963666	88963666	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:88963666G>C	uc011khi.1	+	4	1908	c.1370G>C	c.(1369-1371)TGG>TCG	p.W457S		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	457						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ACTCTTCAATGGCCTACGGAA	0.418		NA								HNSCC(36;0.09)			12	63					0	0	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635071	122635071	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:122635071C>A	uc003vkl.1	-	1	684	c.618G>T	c.(616-618)CAG>CAT	p.Q206H		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	206	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						GATGTTGTATCTGCTTGGTCA	0.463		NA											18	92					1.01e-13	5.46e-13	1	0
PAX4	5078	broad.mit.edu	37	7	127253563	127253563	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:127253563C>T	uc010lld.1	-	5	768	c.562G>A	c.(562-564)GAT>AAT	p.D188N	PAX4_uc003vmf.2_Missense_Mutation_p.D186N|PAX4_uc003vmg.1_Missense_Mutation_p.D188N|PAX4_uc003vmh.2_Missense_Mutation_p.D186N	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	196	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCACTGAATCAGGATACTGC	0.577		NA											15	55					0	0	0	0
AGK	55750	broad.mit.edu	37	7	141333766	141333766	+	Silent	SNP	C	C	T	rs144977618		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:141333766C>T	uc003vwi.2	+	10	825	c.654C>T	c.(652-654)GGC>GGT	p.G218G	AGK_uc011krg.1_RNA	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	218					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)					GAGATGCTGGCGTCAAAGTTA	0.368		NA											22	60					0	0	0	0
SLC4A2	6522	broad.mit.edu	37	7	150771490	150771490	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:150771490G>A	uc003wit.3	+	18	3051	c.2795G>A	c.(2794-2796)CGG>CAG	p.R932Q	SLC4A2_uc011kve.1_Missense_Mutation_p.R923Q|SLC4A2_uc003wiu.3_Missense_Mutation_p.R918Q|SLC4A2_uc003wiv.3_Missense_Mutation_p.R126Q	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	932	Membrane (anion exchange).|Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTCAGATCCGGCGGGTGATT	0.597		NA											35	98					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151848538	151848538	+	Missense_Mutation	SNP	G	G	A	rs139111507	byFrequency	TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:151848538G>A	uc003wla.2	-	50	12874	c.12655C>T	c.(12655-12657)CTT>TTT	p.L4219F	MLL3_uc003wkz.2_Missense_Mutation_p.L3337F|MLL3_uc003wkx.2_Missense_Mutation_p.L377F|MLL3_uc003wky.2_Missense_Mutation_p.L1783F	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4219					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGTTCAAAAGGGTCAGATCT	0.463		NA	N		medulloblastoma								6	20					0	0	0	0
NEIL2	252969	broad.mit.edu	37	8	11637389	11637389	+	Missense_Mutation	SNP	G	G	A	rs113905789		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr8:11637389G>A	uc003wug.2	+	3	1096	c.421G>A	c.(421-423)GTT>ATT	p.V141I	NEIL2_uc003wue.2_Missense_Mutation_p.V141I|NEIL2_uc003wuf.2_Missense_Mutation_p.V80I|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	141					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		GTTTGGCAGCGTTTGGGTGAA	0.572		NA						BER_DNA_glycosylases					34	75					0	0	0	0
PSD3	23362	broad.mit.edu	37	8	18725364	18725364	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr8:18725364C>T	uc003wza.2	-	4	1557	c.1454G>A	c.(1453-1455)CGC>CAC	p.R485H		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	485					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TTCTTTAATGCGCTGTTGTAT	0.463		NA											45	154					0	0	0	0
MYST3	7994	broad.mit.edu	37	8	41791631	41791631	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr8:41791631G>A	uc010lxb.2	-	18	4651	c.4107C>T	c.(4105-4107)ACC>ACT	p.T1369T	MYST3_uc010lxc.2_Silent_p.T1369T|MYST3_uc003xon.3_Silent_p.T1369T	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1369					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			AATCCAGCTCGGTTTCCTCTT	0.502		NA											15	93					0	0	0	0
DENND4C	55667	broad.mit.edu	37	9	19346744	19346744	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:19346744C>G	uc003znq.2	+	18	3155	c.3122C>G	c.(3121-3123)TCA>TGA	p.S1041*	DENND4C_uc011lnc.1_Nonsense_Mutation_p.S371*|DENND4C_uc011lnd.1_Nonsense_Mutation_p.S329*|DENND4C_uc003znr.2_Nonsense_Mutation_p.S329*|DENND4C_uc003zns.2_Nonsense_Mutation_p.S223*|DENND4C_uc003znt.2_Nonsense_Mutation_p.S223*	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1041						integral to membrane				ovary(1)|skin(1)	2						GAGAGGAGATCAAGCCTACCT	0.433		NA											12	93					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0	0
KIF24	347240	broad.mit.edu	37	9	34290194	34290194	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:34290194C>T	uc003zua.3	-	5	1225	c.1105G>A	c.(1105-1107)GAC>AAC	p.D369N	KIF24_uc010mkb.2_Missense_Mutation_p.D400N	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	369	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			TTTAGGAGGTCATAAAGCTGT	0.413		NA											22	82					0	0	0	0
RECK	8434	broad.mit.edu	37	9	36110025	36110025	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:36110025C>A	uc003zyv.2	+	15	1923	c.1837C>A	c.(1837-1839)CGC>AGC	p.R613S	RECK_uc003zyw.2_Missense_Mutation_p.R485S|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	613						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GTGCTCTACCCGCCTTTGCCT	0.473		NA											6	153					0.00198382	0.00932875	1	0
IARS	3376	broad.mit.edu	37	9	95043159	95043159	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:95043159G>A	uc004art.1	-	7	871	c.614C>T	c.(613-615)TCA>TTA	p.S205L	IARS_uc004ars.1_Missense_Mutation_p.S50L|IARS_uc004aru.3_Missense_Mutation_p.S205L|IARS_uc010mqr.2_Missense_Mutation_p.S95L|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	205					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	TACAAATACTGAAGGATCTTG	0.368		NA											5	35					0	0	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111745573	111745573	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:111745573C>T	uc004bdo.1	-	6	794	c.752G>A	c.(751-753)TGC>TAC	p.C251Y	CTNNAL1_uc010mts.1_5'UTR|CTNNAL1_uc010mtt.1_Missense_Mutation_p.C251Y|CTNNAL1_uc004bdp.1_Missense_Mutation_p.C251Y	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	251					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		GGCTGATTCGCAGTTAGGATG	0.338		NA											10	41					0	0	0	0
OLFM1	10439	broad.mit.edu	37	9	138011897	138011897	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:138011897A>G	uc010nar.2	+	6	1647	c.1331A>G	c.(1330-1332)AAC>AGC	p.N444S	OLFM1_uc004cfl.3_Missense_Mutation_p.N426S|OLFM1_uc004cfn.3_Missense_Mutation_p.N195S	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	444	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CCATTCCAGAACAAATACTCC	0.537		NA											13	82					0	0	0	0
RS1	6247	broad.mit.edu	37	X	18662590	18662590	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:18662590A>C	uc004cyo.2	-	5	517	c.482T>G	c.(481-483)CTG>CGG	p.L161R	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	161	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					AATCCAGTTCAGGCGCTCATC	0.532		NA											6	95					0	0	0	0
FAM47A	158724	broad.mit.edu	37	X	34149003	34149003	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:34149003C>T	uc004ddg.2	-	1	1426	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	465										ovary(4)|central_nervous_system(1)	5						AGGCAGGGTTCCCCACAAGGG	0.602		NA											13	45					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70342193	70342193	+	Silent	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:70342193G>A	uc004dyy.2	+	8	1444	c.1245G>A	c.(1243-1245)CAG>CAA	p.Q415Q	MED12_uc011mpq.1_Silent_p.Q415Q|MED12_uc004dyz.2_Silent_p.Q415Q|MED12_uc004dza.2_Silent_p.Q262Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	415					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CCTTCACTCAGCAGGTATGTC	0.483		NA											17	39					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105183934	105183934	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:105183934G>A	uc004emd.2	+	23	4171	c.3868G>A	c.(3868-3870)GAA>AAA	p.E1290K	NRK_uc010npc.1_Missense_Mutation_p.E958K	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1290	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TAATGATCCAGAAAGTAAAAG	0.378		NA								HNSCC(51;0.14)			4	14					0	0	0	0
IRS4	8471	broad.mit.edu	37	X	107979141	107979141	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:107979141C>T	uc004eoc.2	-	1	467	c.434G>A	c.(433-435)CGG>CAG	p.R145Q		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	145	PH.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GATCACGCGCCGCGGTGGAAT	0.632		NA											7	35					0	0	0	0
TMEM187	8269	broad.mit.edu	37	X	153247752	153247752	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:153247752T>C	uc004fjq.2	+	2	773	c.239T>C	c.(238-240)CTG>CCG	p.L80P	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	80						integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGATGGGGCTGGGTCCCCGC	0.692		NA											7	24					0	0	0	0
OSGEPL1	64172	broad.mit.edu	37	2	190619979	190619982	+	Frame_Shift_Del	DEL	ACAG	ACAG	-			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:190619979_190619982delACAG	uc002uqz.1	-	3	1060_1063	c.526_529delCTGT	c.(526-531)CTGTTGfs	p.L176fs	OSGEPL1_uc002ura.1_RNA|OSGEPL1_uc010zfy.1_Frame_Shift_Del_p.L176fs	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	176_177					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			ACTAATGCCAACAGACAGTGACCT	0.368		NA											19	84	---	---	---	---	NA	NA	NA	NA