Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PIK3R3	8503	broad.mit.edu	37	1	46511672	46511672	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr1:46511672C>T	uc001cpb.3	-	9	1861	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	PIK3R3_uc009vyb.2_Missense_Mutation_p.E310K|PIK3R3_uc009vyc.2_Missense_Mutation_p.E386K|PIK3R3_uc001cpc.3_Missense_Mutation_p.E369K|PIK3R3_uc010olw.1_Missense_Mutation_p.E415K|PIK3R3_uc010olv.1_Missense_Mutation_p.E159K	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	369	SH2 2.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					AGCAAGTCCTCTGCTTGTACT	0.398		NA											20	80					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197091638	197091638	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr1:197091638C>A	uc001gtu.2	-	14	3735	c.3478G>T	c.(3478-3480)GCT>TCT	p.A1160S	ASPM_uc001gtv.2_Missense_Mutation_p.A1160S|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1160	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGACATATAGCGTCAAATGGC	0.413		NA											5	12					1.24e-05	2.22e-05	1	0
PGBD2	267002	broad.mit.edu	37	1	249212056	249212056	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr1:249212056G>T	uc001ifh.2	+	3	1420	c.1273G>T	c.(1273-1275)GCT>TCT	p.A425S	PGBD2_uc001ifg.2_Missense_Mutation_p.A174S|PGBD2_uc009xhd.2_Missense_Mutation_p.A422S	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	425										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTGCTCCAATGCTGTGGGCAT	0.517		NA											7	38					5.18e-06	9.47e-06	1	0
TALDO1	6888	broad.mit.edu	37	11	755976	755976	+	Silent	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr11:755976G>A	uc001lqz.2	+	2	245	c.195G>A	c.(193-195)GCG>GCA	p.A65A	TALDO1_uc010qwl.1_Silent_p.A65A|TALDO1_uc001lra.2_Silent_p.A65A	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	65					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		TGGAGGAGGCGATTGCCTATG	0.632		NA											4	27					0	0	0	0
ATM	472	broad.mit.edu	37	11	108206667	108206667	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr11:108206667A>C	uc001pkb.1	+	56	8632	c.8247A>C	c.(8245-8247)AAA>AAC	p.K2749N	ATM_uc009yxr.1_Missense_Mutation_p.K2749N|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.K1401N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2749	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGAAGAGGAAATTAACTATCT	0.328		NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			15	13					0	0	0	0
C3AR1	719	broad.mit.edu	37	12	8212707	8212707	+	Silent	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr12:8212707G>A	uc001qtv.1	-	2	167	c.75C>T	c.(73-75)CTC>CTT	p.L25L		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	25	Helical; Name=1; (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		TGACCATGGAGAGAATTACTG	0.488		NA											30	68					0	0	0	0
CUX2	23316	broad.mit.edu	37	12	111758147	111758147	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr12:111758147G>T	uc001tsa.1	+	17	2487	c.2334G>T	c.(2332-2334)GAG>GAT	p.E778D		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	778						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCAAGTCCGAGATCGGCGACG	0.721		NA											18	39					5.39e-06	9.79e-06	1	0
GTF3A	2971	broad.mit.edu	37	13	28004707	28004707	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr13:28004707A>T	uc001ure.2	+	4	631	c.437A>T	c.(436-438)CAT>CTT	p.H146L	GTF3A_uc001urf.2_5'UTR|GTF3A_uc001urg.2_RNA	NM_002097	NP_002088	Q92664	TF3A_HUMAN	transcription factor IIIA	146	C2H2-type 4; atypical.				regulation of transcription, DNA-dependent|rRNA transcription|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding|RNA binding|zinc ion binding				0		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.11)|OV - Ovarian serous cystadenocarcinoma(117;0.158)		TTTAAGAAACATCAGCAGCTG	0.383		NA											9	9					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77662989	77662989	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr13:77662989G>A	uc001vkf.2	-	62	10680	c.10589C>T	c.(10588-10590)GCT>GTT	p.A3530V	MYCBP2_uc010aev.2_Missense_Mutation_p.A2934V|MYCBP2_uc001vke.2_Missense_Mutation_p.A150V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AACTCGACAAGCAGATTTCCT	0.353		NA											17	20					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23447604	23447604	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:23447604G>A	uc001whz.2	-	2	1433	c.1057C>T	c.(1057-1059)CAG>TAG	p.Q353*	JUB_uc001why.2_5'Flank	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	353	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		TCCAGGGCCTGGCAGGCATTG	0.542		NA											124	49					0	0	0	0
TM9SF1	10548	broad.mit.edu	37	14	24679887	24679887	+	Silent	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:24679887A>G	uc010tob.1	-	4	1159	c.525T>C	c.(523-525)CCT>CCC	p.P175P	CHMP4A_uc001wni.2_Silent_p.P192P|CHMP4A_uc010toc.1_RNA|CHMP4A_uc001wnj.2_Silent_p.P192P	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	Error:Variant_position_missing_in_O15321_after_alignment					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		CAAAGCCCATAGGCCGAGAAA	0.507		NA											3	152					0	0	0	0
SOS2	6655	broad.mit.edu	37	14	50597456	50597456	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:50597456T>C	uc001wxs.3	-	20	3198	c.3100A>G	c.(3100-3102)AAA>GAA	p.K1034E	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.K1001E	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1034					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					CCAGGAGATTTTAAGGAAAAA	0.383		NA											6	56					0	0	0	0
EML5	161436	broad.mit.edu	37	14	89091394	89091394	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:89091394C>T	uc001xxg.2	-	36	5004	c.4818G>A	c.(4816-4818)GCG>GCA	p.A1606A	EML5_uc001xxf.2_Silent_p.A393A|EML5_uc001xxh.1_Silent_p.A737A	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1598	WD 23.					cytoplasm|microtubule				ovary(3)	3						TGTGAGCTCTCGCCACGATTC	0.502		NA											6	67					0	0	0	0
KLC1	3831	broad.mit.edu	37	14	104167058	104167058	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:104167058C>T	uc001yno.2	+	14	2025	c.1717C>T	c.(1717-1719)CGC>TGC	p.R573C	KLC1_uc010tyf.1_Silent_p.T616T|KLC1_uc001yns.2_RNA|XRCC3_uc001yny.3_Intron|XRCC3_uc001ynx.3_Intron|XRCC3_uc001ynz.3_Intron|XRCC3_uc001yoa.3_Intron	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	573					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				AAGACGCCACCGCTAACGTGA	0.627		NA											11	70					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28467346	28467346	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr15:28467346T>C	uc001zbj.2	-	36	5586	c.5480A>G	c.(5479-5481)AAC>AGC	p.N1827S		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1827					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCCTCAACGTTGTCACAACT	0.458		NA											9	29					0	0	0	0
ACTC1	70	broad.mit.edu	37	15	35082732	35082732	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr15:35082732A>G	uc001ziu.1	-	7	1258	c.1015T>C	c.(1015-1017)TAC>CAC	p.Y339H	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	339					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CAGACAGAGTATTTACGCTCA	0.478		NA											21	69					0	0	0	0
PKD1	5310	broad.mit.edu	37	16	2160250	2160250	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr16:2160250C>G	uc002cos.1	-	15	5127	c.4918G>C	c.(4918-4920)GGT>CGT	p.G1640R	PKD1_uc002cot.1_Missense_Mutation_p.G1640R	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1640	Extracellular (Potential).|PKD 12.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TAGCGGCCACCGCCCACCACC	0.617		NA											19	13					0	0	0	0
TAOK2	9344	broad.mit.edu	37	16	30002124	30002124	+	Missense_Mutation	SNP	A	A	G	rs140227077		TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr16:30002124A>G	uc002dvc.1	+	18	3248	c.2465A>G	c.(2464-2466)CAG>CGG	p.Q822R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GATGAGACCCAGGAGGCAGAG	0.612		NA											18	34					0	0	0	0
ACACA	31	broad.mit.edu	37	17	35620680	35620680	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr17:35620680G>A	uc002hnm.2	-	11	1317	c.1126C>T	c.(1126-1128)CGT>TGT	p.R376C	ACACA_uc002hnk.2_Missense_Mutation_p.R298C|ACACA_uc002hnl.2_Missense_Mutation_p.R318C|ACACA_uc002hnn.2_Missense_Mutation_p.R376C|ACACA_uc002hno.2_Missense_Mutation_p.R413C|ACACA_uc010cuz.2_Missense_Mutation_p.R376C	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	376	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAGCAATCACGACCAAACAAA	0.433		NA											19	180					0	0	0	0
PSME3	10197	broad.mit.edu	37	17	40986550	40986550	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr17:40986550A>G	uc002ibr.2	+	3	320	c.94A>G	c.(94-96)AAT>GAT	p.N32D	PSME3_uc002ibp.2_5'UTR|PSME3_uc002ibq.2_Missense_Mutation_p.N32D|PSME3_uc002ibs.2_Missense_Mutation_p.N43D|PSME3_uc010whd.1_5'UTR	NM_005789	NP_005780	P61289	PSME3_HUMAN	proteasome activator subunit 3 isoform 1	32					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome activator complex	endopeptidase activator activity|identical protein binding|MDM2 binding|p53 binding				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CTTGGTGGCAAATTTTTTCCC	0.328		NA											33	86					0	0	0	0
RTTN	25914	broad.mit.edu	37	18	67801778	67801778	+	Splice_Site	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr18:67801778C>T	uc002lkp.2	-	23	2954	c.2886_splice	c.e23-1	p.W962_splice	RTTN_uc002lko.2_Splice_Site|RTTN_uc010xfb.1_Splice_Site_p.W50_splice	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin								binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				ATTAACAGACCTATTTCATAA	0.333		NA											4	31					0	0	0	0
SAFB2	9667	broad.mit.edu	37	19	5604923	5604923	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:5604923T>C	uc002mcd.2	-	10	1533	c.1321A>G	c.(1321-1323)AAC>GAC	p.N441D		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	441	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CTGCGGGCGTTCGTTACCACT	0.517		NA											7	47					0	0	0	0
S1PR5	53637	broad.mit.edu	37	19	10624909	10624909	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:10624909A>T	uc002mot.1	-	2	836	c.779T>A	c.(778-780)TTT>TAT	p.F260Y	S1PR5_uc002mou.1_Missense_Mutation_p.F260Y	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	260	Helical; Name=6; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						ACATGCCACAAAGGCCAGGAG	0.716		NA											7	4					0	0	0	0
ZNF574	64763	broad.mit.edu	37	19	42584699	42584699	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:42584699C>T	uc002osm.3	+	2	2110	c.1941C>T	c.(1939-1941)TCC>TCT	p.S647S	ZNF574_uc002osk.3_Silent_p.S737S	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	647	C2H2-type 15; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CCTTCCCCTCCTCACTGCGGC	0.697		NA											16	64					0	0	0	0
IRGQ	126298	broad.mit.edu	37	19	44097383	44097383	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:44097383C>T	uc002oww.2	-	2	785	c.667G>A	c.(667-669)GCA>ACA	p.A223T	IRGQ_uc010eiv.2_Missense_Mutation_p.A223T	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	223							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				TCTAGCCGTGCGCTGCCCAGG	0.682		NA											22	46					0	0	0	0
LILRB1	10859	broad.mit.edu	37	19	55144748	55144748	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:55144748C>G	uc002qgj.2	+	8	1580	c.1240C>G	c.(1240-1242)CCC>GCC	p.P414A	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P414A|LILRB1_uc002qgk.2_Missense_Mutation_p.P414A|LILRB1_uc002qgm.2_Missense_Mutation_p.P414A|LILRB1_uc010erq.2_Missense_Mutation_p.P414A|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	414	Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CCCCAGTGACCCCCTGGAGCT	0.622		NA								HNSCC(37;0.09)			3	78					0	0	0	0
SF3B1	23451	broad.mit.edu	37	2	198285265	198285265	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr2:198285265T>C	uc002uue.2	-	4	350	c.302A>G	c.(301-303)TAT>TGT	p.Y101C	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Missense_Mutation_p.Y101C|SF3B1_uc002uug.2_Missense_Mutation_p.Y101C	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	101					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAATGGATCATACTGAAAAGA	0.358		NA											37	23					0	0	0	0
KIF1A	547	broad.mit.edu	37	2	241689923	241689923	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr2:241689923A>G	uc002vzy.2	-	26	2743	c.2597T>C	c.(2596-2598)CTG>CCG	p.L866P	KIF1A_uc010fzk.2_Missense_Mutation_p.L967P|KIF1A_uc002vzz.1_Missense_Mutation_p.L967P	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	866					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACGGTGTACCAGGGGAACGGG	0.652		NA											3	52					0	0	0	0
CHGB	1114	broad.mit.edu	37	20	5903296	5903296	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr20:5903296A>G	uc002wmg.2	+	4	812	c.506A>G	c.(505-507)GAG>GGG	p.E169G	CHGB_uc010zqz.1_5'UTR	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	169	Poly-Glu.					extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAGGAGGAGGAGGGAGAGAAC	0.512		NA											3	47					0	0	0	0
FOXS1	2307	broad.mit.edu	37	20	30433105	30433105	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr20:30433105G>T	uc002wwt.1	-	1	316	c.241C>A	c.(241-243)CGC>AGC	p.R81S		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	81	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						CGGTCATCGCGGGGCACCTTG	0.637		NA											17	62					6.5e-13	1.29e-12	1	0
GSS	2937	broad.mit.edu	37	20	33519179	33519179	+	Silent	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr20:33519179G>A	uc002xbg.2	-	11	1151	c.1071C>T	c.(1069-1071)GCC>GCT	p.A357A	GSS_uc010zun.1_Silent_p.A229A|GSS_uc010zuo.1_Silent_p.A246A|GSS_uc010zup.1_Silent_p.A288A|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Silent_p.A87A	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	357					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	ACCGGCTAGGGGCAGCAAGGG	0.562		NA											9	33					0	0	0	0
CABIN1	23523	broad.mit.edu	37	22	24439496	24439496	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr22:24439496C>T	uc002zzi.1	+	6	603	c.476C>T	c.(475-477)CCC>CTC	p.P159L	CABIN1_uc002zzj.1_Missense_Mutation_p.P159L|CABIN1_uc002zzl.1_Missense_Mutation_p.P159L|CABIN1_uc010guk.1_Missense_Mutation_p.P114L|CABIN1_uc002zzk.1_Missense_Mutation_p.P114L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	159					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GACCACTGGCCCTGTTTGGAT	0.512		NA											15	83					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26164180	26164180	+	Silent	SNP	T	T	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr22:26164180T>C	uc003abz.1	+	4	547	c.297T>C	c.(295-297)CCT>CCC	p.P99P	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	99	Ser-rich.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CAAGCTCTCCTGGGAGCTCAG	0.582		NA											16	136					0	0	0	0
PARP15	165631	broad.mit.edu	37	3	122354785	122354785	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:122354785C>T	uc003efm.2	+	12	1941	c.1875C>T	c.(1873-1875)TTC>TTT	p.F625F	PARP15_uc003efn.2_Silent_p.F430F|PARP15_uc003efo.1_Silent_p.F372F|PARP15_uc003efp.1_Silent_p.F391F|PARP15_uc011bjt.1_Silent_p.F322F	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	603	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		CTGGAGTCTTCACAAAGGGAC	0.488		NA											16	40					0	0	0	0
DNAJC13	23317	broad.mit.edu	37	3	132219737	132219737	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:132219737C>T	uc003eor.2	+	39	4581	c.4516C>T	c.(4516-4518)CGG>TGG	p.R1506W		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1506							heat shock protein binding			ovary(1)|breast(1)	2						GGATCTCTGTCGGGTACTATA	0.373		NA											35	79					0	0	0	0
MED12L	116931	broad.mit.edu	37	3	151112629	151112629	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:151112629C>T	uc003eyp.2	+	37	5727	c.5689C>T	c.(5689-5691)CAA>TAA	p.Q1897*	MED12L_uc011bnz.1_Nonsense_Mutation_p.Q1757*	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1897	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTTCTCAGGCAAGCCCAGAC	0.512		NA											16	101					0	0	0	0
DGKG	1608	broad.mit.edu	37	3	185975671	185975671	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:185975671C>T	uc003fqa.2	-	17	2019	c.1482G>A	c.(1480-1482)GGG>GGA	p.G494G	DGKG_uc003fqb.2_Silent_p.G455G|DGKG_uc003fqc.2_Silent_p.G469G|DGKG_uc011brx.1_Silent_p.G435G	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	494	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AGCCAACTGTCCCATCTCCAC	0.448		NA											46	63					0	0	0	0
PGM2	55276	broad.mit.edu	37	4	37848566	37848566	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:37848566T>G	uc011byb.1	+	9	1095	c.1022T>G	c.(1021-1023)GTG>GGG	p.V341G	PGM2_uc011bya.1_Missense_Mutation_p.V202G|PGM2_uc011byc.1_Missense_Mutation_p.V181G	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	341					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						GAATGGAGGGTGTTTTCAGGC	0.428		NA											8	73					0	0	0	0
CWH43	80157	broad.mit.edu	37	4	49030675	49030675	+	Silent	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:49030675C>A	uc003gyv.2	+	10	1478	c.1296C>A	c.(1294-1296)ATC>ATA	p.I432I	CWH43_uc011bzl.1_Silent_p.I405I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	432					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						CTGCTGCCATCTGGCCTTTCA	0.448		NA											9	32					1.77e-08	3.33e-08	1	0
ADH1C	126	broad.mit.edu	37	4	100268199	100268199	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:100268199C>T	uc003huu.2	-	3	308	c.223G>A	c.(223-225)GAA>AAA	p.E75K		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	75					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CAAACACTTTCCACGATGCCG	0.512		NA							Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				56	189					0	0	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951990	119951990	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:119951990C>A	uc003icm.3	+	4	2256	c.2060C>A	c.(2059-2061)GCC>GAC	p.A687D	SYNPO2_uc010ina.2_Missense_Mutation_p.A687D|SYNPO2_uc010inb.2_Missense_Mutation_p.A687D|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.A615D	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	687						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TTGCAGGAGGCCAAAAGGAGA	0.463		NA											11	34					1.59e-06	2.92e-06	1	0
ANKH	56172	broad.mit.edu	37	5	14758681	14758681	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:14758681T>A	uc003jfm.3	-	3	671	c.340A>T	c.(340-342)ATC>TTC	p.I114F		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	114	Extracellular (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						AGTTTATTGATAATGTAGTAT	0.418		NA											12	47					0	0	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140724693	140724693	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:140724693G>C	uc003ljm.1	+	1	1093	c.1093G>C	c.(1093-1095)GAA>CAA	p.E365Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.E125Q|PCDHGA3_uc011dap.1_Missense_Mutation_p.E365Q	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	365	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTGGAAGAGAAATTGCTCT	0.443		NA											34	44					0	0	0	0
RNF145	153830	broad.mit.edu	37	5	158630622	158630622	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:158630622C>A	uc003lxp.2	-	2	317	c.4G>T	c.(4-6)GCT>TCT	p.A2S	RNF145_uc011ddy.1_Missense_Mutation_p.A16S|RNF145_uc003lxo.1_Missense_Mutation_p.A30S|RNF145_uc011ddz.1_Missense_Mutation_p.A19S|RNF145_uc010jiq.1_Missense_Mutation_p.A32S|RNF145_uc011dea.1_Missense_Mutation_p.A18S	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	2						integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTTTGCAGCCATGTTGttt	0.363		NA											15	30					6.32e-08	1.18e-07	1	0
TBC1D9B	23061	broad.mit.edu	37	5	179320402	179320402	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:179320402C>T	uc003mlh.2	-	5	680	c.643G>A	c.(643-645)GAG>AAG	p.E215K	TBC1D9B_uc003mli.2_Missense_Mutation_p.E215K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E215K	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	215						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGATGCTCTCGGGGAAGAGC	0.587		NA											17	14					0	0	0	0
FRS3	10817	broad.mit.edu	37	6	41738404	41738404	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr6:41738404C>A	uc003orc.1	-	7	1676	c.1432G>T	c.(1432-1434)GGC>TGC	p.G478C		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	478					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGGCGGTGCCATCGTCTCGG	0.627		NA											17	64					3.41e-10	6.51e-10	1	0
PKHD1	5314	broad.mit.edu	37	6	51524466	51524466	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr6:51524466C>T	uc003pah.1	-	61	10734	c.10458G>A	c.(10456-10458)TTG>TTA	p.L3486L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3486	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTTGTTCCCCAATAGAAAAA	0.453		NA											14	32					0	0	0	0
FAM135A	57579	broad.mit.edu	37	6	71247998	71247998	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr6:71247998C>T	uc003pfj.2	+	18	4255	c.4122C>T	c.(4120-4122)CTC>CTT	p.L1374L	FAM135A_uc003pfi.2_Silent_p.L1178L|FAM135A_uc003pfh.2_Silent_p.L1161L|FAM135A_uc003pfl.2_Silent_p.L1041L|FAM135A_uc003pfn.2_Silent_p.L580L|FAM135A_uc003pfo.1_Silent_p.L745L|FAM135A_uc010kan.1_Intron	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	1374										central_nervous_system(1)	1						CTCTAGGTCTCTGGTTTATGC	0.308		NA											11	14					0	0	0	0
TBX20	57057	broad.mit.edu	37	7	35288434	35288434	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:35288434G>C	uc011kas.1	-	3	411	c.400C>G	c.(400-402)CGG>GGG	p.R134G		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	134	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						AAGGACACCCGGATGGTTGGA	0.478		NA											5	48					0	0	0	0
URGCP	55665	broad.mit.edu	37	7	43917489	43917489	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:43917489T>C	uc003tiw.2	-	6	1630	c.1573A>G	c.(1573-1575)AGG>GGG	p.R525G	URGCP_uc003tiu.2_Missense_Mutation_p.R482G|URGCP_uc003tiv.2_Missense_Mutation_p.R450G|URGCP_uc003tix.2_Missense_Mutation_p.R516G|URGCP_uc003tiy.2_Missense_Mutation_p.R482G|URGCP_uc003tiz.2_Missense_Mutation_p.R482G|URGCP_uc011kbj.1_Missense_Mutation_p.R482G	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	525					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						AGCTCAGCCCTGTGCTTCTCA	0.647		NA											3	89					0	0	0	0
MGC26647	219557	broad.mit.edu	37	7	88423535	88423535	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:88423535A>G	uc003ujv.2	-	2	904	c.722T>C	c.(721-723)CTG>CCG	p.L241P	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	241											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			CTCAGAATCCAGAGTGATGTG	0.403		NA											15	23					0	0	0	0
AKAP9	10142	broad.mit.edu	37	7	91659267	91659267	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:91659267G>T	uc003ulg.2	+	15	4432	c.4207G>T	c.(4207-4209)GGA>TGA	p.G1403*	AKAP9_uc003ule.2_Nonsense_Mutation_p.G1415*|AKAP9_uc003ulf.2_Nonsense_Mutation_p.G1403*|AKAP9_uc003uli.2_Nonsense_Mutation_p.G1028*	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1415					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AATGTACCCTGGAAGTTGTGT	0.269		NA	T	BRAF	papillary thyroid								47	47					1.4e-22	2.82e-22	1	0
C7orf64	84060	broad.mit.edu	37	7	92161858	92161858	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:92161858A>G	uc003ulz.2	+	3	484	c.443A>G	c.(442-444)AAT>AGT	p.N148S	C7orf64_uc011khu.1_Missense_Mutation_p.N148S|C7orf64_uc003uma.2_Missense_Mutation_p.N148S	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	148							nucleotide binding			ovary(2)	2						ACTACTGAAAATAAAGGTATG	0.204		NA											22	18					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52320774	52320774	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:52320774G>A	uc003xqu.3	-	17	3511	c.3410C>T	c.(3409-3411)TCG>TTG	p.S1137L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1137					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGTGGCAGCCGAATCCACGGC	0.522		NA											10	125					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52336259	52336259	+	Silent	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:52336259G>A	uc003xqu.3	-	14	1772	c.1671C>T	c.(1669-1671)TTC>TTT	p.F557F		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	557	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATCCACATGGAATTTACCAC	0.433		NA											9	38					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95531399	95531399	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:95531399C>T	uc003ygo.1	-	9	2340	c.2327G>A	c.(2326-2328)AGC>AAC	p.S776N	KIAA1429_uc003ygp.2_Missense_Mutation_p.S776N|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	776					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTGAAAATGGCTGAACAGTTC	0.423		NA											8	55					0	0	0	0
UBR5	51366	broad.mit.edu	37	8	103287969	103287969	+	Silent	SNP	T	T	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:103287969T>A	uc003ykr.1	-	46	6630	c.6597A>T	c.(6595-6597)GTA>GTT	p.V2199V	UBR5_uc003yks.1_Silent_p.V2199V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2199					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTCCATGAATACCCTGCCGA	0.423		NA											12	32					0	0	0	0
MTSS1	9788	broad.mit.edu	37	8	125597387	125597387	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:125597387C>A	uc003yrk.2	-	6	935	c.401G>T	c.(400-402)CGC>CTC	p.R134L	MTSS1_uc003yrj.2_Missense_Mutation_p.R134L|MTSS1_uc003yrl.2_Missense_Mutation_p.R134L	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	134	IMD.|Potential.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TATCTCTTGGCGGGCTTTCTT	0.363		NA											49	115					9.87e-16	1.97e-15	1	0
RFX3	5991	broad.mit.edu	37	9	3263051	3263051	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:3263051G>A	uc003zhr.2	-	14	1801	c.1489C>T	c.(1489-1491)CGA>TGA	p.R497*	RFX3_uc010mhd.2_Nonsense_Mutation_p.R497*|RFX3_uc003zhs.1_Nonsense_Mutation_p.R497*	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	497					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		GTGTATCTTCGCAGAGTCTGG	0.483		NA											23	98					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627757	43627757	+	Silent	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:43627757A>G	uc011lrb.1	-	4	959	c.930T>C	c.(928-930)TGT>TGC	p.C310C		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	310						integral to membrane					0						CTTCCATCTGACAGGTCTCTG	0.532		NA											5	409					0	0	0	0
BSPRY	54836	broad.mit.edu	37	9	116131934	116131934	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:116131934C>T	uc004bhg.3	+	6	769	c.721C>T	c.(721-723)CCC>TCC	p.P241S	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	241	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GACAGTCAGCCCCTTCCTGCA	0.577		NA											14	84					0	0	0	0
COL5A1	1289	broad.mit.edu	37	9	137676879	137676879	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:137676879A>C	uc004cfe.2	+	30	2911	c.2529A>C	c.(2527-2529)GAA>GAC	p.E843D		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	843	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATGGCCCTGAAGGCCCAAAGG	0.622		NA											34	29					0	0	0	0
SEC16A	9919	broad.mit.edu	37	9	139354513	139354513	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:139354513C>T	uc004chx.2	-	14	5363	c.5054G>A	c.(5053-5055)CGG>CAG	p.R1685Q	SEC16A_uc004chu.2_5'Flank|SEC16A_uc004chv.3_Missense_Mutation_p.R1075Q|SEC16A_uc004chw.2_Missense_Mutation_p.R1685Q|SEC16A_uc010nbn.2_Missense_Mutation_p.R1685Q	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1507					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGCAGGCATCCGTCCGGACAT	0.592		NA											11	8					0	0	0	0
MXRA5	25878	broad.mit.edu	37	X	3241944	3241944	+	Silent	SNP	C	C	T			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:3241944C>T	uc004crg.3	-	5	1939	c.1782G>A	c.(1780-1782)TCG>TCA	p.S594S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	594	Ig-like C2-type 2.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCAATGTCACCGACTCCCCTG	0.473		NA											5	14					0	0	0	0
GUCY2F	2986	broad.mit.edu	37	X	108718934	108718934	+	Silent	SNP	A	A	G			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:108718934A>G	uc004eod.3	-	2	508	c.232T>C	c.(232-234)TTA>CTA	p.L78L	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	78	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCAATGGCTAATCGCGCAGCA	0.527		NA									OREG0019905	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	17					0	0	0	0
ATP11C	286410	broad.mit.edu	37	X	138832233	138832233	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:138832233C>A	uc004faz.2	-	24	2887	c.2788G>T	c.(2788-2790)GAA>TAA	p.E930*	ATP11C_uc004fax.2_Nonsense_Mutation_p.E138*|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Nonsense_Mutation_p.E930*	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	930	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ATGTGCTGTTCCAGTAGACTA	0.393		NA											5	59					1.24e-05	2.22e-05	1	0
ARHGAP4	393	broad.mit.edu	37	X	153186904	153186904	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:153186904T>A	uc004fjk.1	-	3	391	c.349A>T	c.(349-351)AGC>TGC	p.S117C	ARHGAP4_uc011mzf.1_Missense_Mutation_p.S94C|ARHGAP4_uc004fjl.1_Missense_Mutation_p.S117C|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	117					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGGCCGCGCTCTCCCGGCTC	0.692		NA											7	7					0	0	0	0
SPRYD5	84767	broad.mit.edu	37	11	55658941	55658943	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr11:55658941_55658943delGTG	uc010rip.1	+	7	1284_1286	c.1192_1194delGTG	c.(1192-1194)GTGdel	p.V399del	SPRYD5_uc010riq.1_In_Frame_Del_p.V256del	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	399	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CTCCCCACTTGTGGTGCAATATG	0.448		NA											19	63	---	---	---	---	NA	NA	NA	NA
MLL2	8085	broad.mit.edu	37	12	49444269	49444276	+	Frame_Shift_Del	DEL	GGGAACCA	GGGAACCA	-			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr12:49444269_49444276delGGGAACCA	uc001rta.3	-	11	3095_3102	c.3095_3102delTGGTTCCC	c.(3094-3102)CTGGTTCCCfs	p.L1032fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1032_1034	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGAGTTTTGGGGAACCAGGGAATGCTG	0.611		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			9	45	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578241	7578241	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr17:7578241delA	uc002gim.2	-	6	802	c.608delT	c.(607-609)GTGfs	p.V203fs	TP53_uc002gig.1_Frame_Shift_Del_p.V203fs|TP53_uc002gih.2_Frame_Shift_Del_p.V203fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.V71fs|TP53_uc010cng.1_Frame_Shift_Del_p.V71fs|TP53_uc002gii.1_Frame_Shift_Del_p.V71fs|TP53_uc010cnh.1_Frame_Shift_Del_p.V203fs|TP53_uc010cni.1_Frame_Shift_Del_p.V203fs|TP53_uc002gij.2_Frame_Shift_Del_p.V203fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.V110fs|TP53_uc002gio.2_Frame_Shift_Del_p.V71fs|TP53_uc010vug.1_Frame_Shift_Del_p.V164fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	203	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		VE -> LV (in a sporadic cancer; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.V203E(6)|p.V203L(3)|p.V203fs*44(3)|p.V203V(3)|p.V203fs*6(2)|p.V203M(2)|p.K164_P219del(1)|p.N200fs*4(1)|p.V203A(1)|p.E204fs*5(1)|p.V203_E204>V*(1)|p.V203_E204>LV(1)|p.G199fs*42(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAATACTCCACACGCAAATT	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	17	---	---	---	---	NA	NA	NA	NA