Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRDM2	7799	broad.mit.edu	37	1	14106924	14106924	+	Silent	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:14106924A>G	uc001avi.2	+	8	3490	c.2634A>G	c.(2632-2634)GTA>GTG	p.V878V	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Silent_p.V878V|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Silent_p.V677V|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	878						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTAGTGCTGTAAAGAAAAGGA	0.423		NA											26	68					0	0	0	0
PDIK1L	149420	broad.mit.edu	37	1	26448944	26448944	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:26448944A>G	uc010oew.1	+	3	1175	c.902A>G	c.(901-903)AAT>AGT	p.N301S	PDIK1L_uc001blj.3_Missense_Mutation_p.N301S|PDIK1L_uc009vsb.2_Missense_Mutation_p.N301S	NM_152835	NP_690048	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	301	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity				0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		AAATCTATGAATGGGCGAATG	0.398		NA											21	45					0	0	0	0
MAP3K6	9064	broad.mit.edu	37	1	27682581	27682581	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:27682581G>C	uc001bny.1	-	27	3896	c.3647C>G	c.(3646-3648)TCA>TGA	p.S1216*	MAP3K6_uc009vsw.1_Nonsense_Mutation_p.S1208*	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1216					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTGGTCCGTTGAAAGAGCAGC	0.562		NA											14	41					0	0	0	0
EPHA10	284656	broad.mit.edu	37	1	38227606	38227606	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:38227606G>A	uc009vvi.2	-	3	407	c.321C>T	c.(319-321)TTC>TTT	p.F107F	EPHA10_uc001cbw.3_Silent_p.F107F	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	107	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACGGAGTGTGAACTGCAGTT	0.622		NA											41	101					0	0	0	0
FPGT	8790	broad.mit.edu	37	1	74671407	74671407	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:74671407A>G	uc001dgb.1	+	4	1713	c.1676A>G	c.(1675-1677)TAT>TGT	p.Y559C	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Missense_Mutation_p.Y184C|FPGT_uc010oqu.1_Missense_Mutation_p.Y305C|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	559					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						CTGAATAGCTATAAGTTGCTG	0.338		NA											17	43					0	0	0	0
CCDC76	54482	broad.mit.edu	37	1	100598746	100598746	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:100598746C>A	uc001dsv.2	+	1	41	c.22C>A	c.(22-24)CCG>ACG	p.P8T	SASS6_uc001dsu.2_5'Flank|SASS6_uc009wdz.2_5'Flank|CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.P8T	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	8					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		CGCGACGTCGCCGCACGCGCC	0.552		NA											8	33					0.000274275	0.000296909	1	0
SYPL2	284612	broad.mit.edu	37	1	110022065	110022065	+	Silent	SNP	G	G	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:110022065G>C	uc001dxp.2	+	6	1080	c.714G>C	c.(712-714)CCG>CCC	p.P238P	SYPL2_uc010ovk.1_Silent_p.P174P	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	238	Cytoplasmic (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		AGGAGACCCCGTGGCATGGAc	0.413		NA											22	51					0	0	0	0
MOV10	4343	broad.mit.edu	37	1	113240920	113240920	+	Silent	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:113240920C>T	uc001eck.2	+	16	2598	c.2328C>T	c.(2326-2328)ATC>ATT	p.I776I	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Silent_p.I776I|MOV10_uc001ecm.2_Silent_p.I716I	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	776					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GCTTTCCCATCATCTTTCACG	0.557		NA											7	28					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145299900	145299900	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:145299900C>G	uc001end.3	+	6	984	c.949C>G	c.(949-951)CAA>GAA	p.Q317E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.Q317E|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	317											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTTCTAACTCAACTGTCCGG	0.428		NA											22	134					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152192700	152192700	+	Missense_Mutation	SNP	C	C	G	rs147754674		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:152192700C>G	uc001ezt.1	-	3	1481	c.1405G>C	c.(1405-1407)GAG>CAG	p.E469Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	469					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTAGACTCGTGGTGACCA	0.567		NA											42	109					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152192821	152192821	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:152192821C>G	uc001ezt.1	-	3	1360	c.1284G>C	c.(1282-1284)CAG>CAC	p.Q428H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	428	4				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGACCCACGCTGGCCGTGGC	0.612		NA											18	44					0	0	0	0
FCRLB	127943	broad.mit.edu	37	1	161697075	161697075	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:161697075C>A	uc001gbh.2	+	8	1138	c.904C>A	c.(904-906)CCA>ACA	p.P302T	FCRLB_uc009wus.2_Missense_Mutation_p.P302T|FCRLB_uc001gbj.2_Silent_p.L253L|FCRLB_uc001gbk.2_Missense_Mutation_p.S267Y|FCRLB_uc001gbl.2_Silent_p.L246L|FCRLB_uc001gbm.2_Missense_Mutation_p.S260Y|FCRLB_uc001gbi.2_Missense_Mutation_p.P302T|FCRLB_uc001gbn.3_Missense_Mutation_p.S304Y	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	302						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CGCCCCAGCTCCATGGGCCGC	0.637		NA											11	36					0.000673444	0.000715133	1	0
FCRLB	127943	broad.mit.edu	37	1	161697178	161697178	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:161697178C>T	uc001gbh.2	+	8	1241	c.1007C>T	c.(1006-1008)TCC>TTC	p.S336F	FCRLB_uc009wus.2_Missense_Mutation_p.S336F|FCRLB_uc001gbj.2_Missense_Mutation_p.P288S|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_Missense_Mutation_p.P281S|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Missense_Mutation_p.S336F|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	336						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			AACACCACCTCCACCGGGCTG	0.692		NA											16	30					0	0	0	0
FAM5B	57795	broad.mit.edu	37	1	177249883	177249883	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:177249883G>A	uc001glf.2	+	8	1883	c.1571G>A	c.(1570-1572)CGC>CAC	p.R524H	FAM5B_uc001glg.2_Missense_Mutation_p.R419H	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	524						extracellular region		p.R524H(1)		skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CAGGATAGCCGCATTGAGGTA	0.567		NA											13	22					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181701838	181701838	+	Silent	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:181701838C>T	uc001gow.2	+	20	2781	c.2616C>T	c.(2614-2616)ACC>ACT	p.T872T	CACNA1E_uc009wxs.2_Silent_p.T760T|CACNA1E_uc001gox.1_Silent_p.T98T|CACNA1E_uc009wxt.2_Silent_p.T98T	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	872	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ACCAGAGGACCCCTTTGTCCC	0.622		NA											10	14					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240370958	240370958	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:240370958C>G	uc010pyd.1	+	5	3071	c.2846C>G	c.(2845-2847)CCC>CGC	p.P949R	FMN2_uc010pye.1_Missense_Mutation_p.P953R	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	949	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCCTCTACCCGGAGCGGCA	0.697		NA											5	20					0	0	0	0
PRDM11	56981	broad.mit.edu	37	11	45246383	45246383	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:45246383C>T	uc001myo.2	+	8	1709	c.1460C>T	c.(1459-1461)TCG>TTG	p.S487L		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	487								p.S487L(1)		upper_aerodigestive_tract(1)	1						CCAGAGTTCTCGGACCCTGCA	0.542		NA											30	68					0	0	0	0
OR4A15	81328	broad.mit.edu	37	11	55135388	55135388	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:55135388T>A	uc010rif.1	+	1	29	c.29T>A	c.(28-30)TTT>TAT	p.F10Y		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATCTCAAATTTATCACTGAC	0.408		NA											7	43					0	0	0	0
GLYAT	10249	broad.mit.edu	37	11	58478154	58478154	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:58478154G>A	uc001nnb.2	-	5	552	c.397C>T	c.(397-399)CTC>TTC	p.L133F	GLYAT_uc001nnc.2_Missense_Mutation_p.L133F	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	133					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	GCCATATAGAGAATGCGTTGT	0.428		NA											32	87					0	0	0	0
ATG2A	23130	broad.mit.edu	37	11	64665596	64665596	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:64665596C>T	uc001obx.2	-	34	4935	c.4820G>A	c.(4819-4821)GGC>GAC	p.G1607D	ATG2A_uc001obw.2_Missense_Mutation_p.G372D	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1607							protein binding			ovary(1)|central_nervous_system(1)	2						GGGGTTGATGCCGGCCACCAG	0.627		NA									OREG0004029	type=REGULATORY REGION|Gene=BC033850|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	143					0	0	0	0
TIGD3	220359	broad.mit.edu	37	11	65123651	65123651	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:65123651G>A	uc001odo.3	+	2	535	c.372G>A	c.(370-372)CTG>CTA	p.L124L		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	124	H-T-H motif (By similarity).|HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						TCGGCTGGCTGGTCCGCTGGA	0.662		NA											11	42					0	0	0	0
PCNXL3	399909	broad.mit.edu	37	11	65393198	65393198	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:65393198G>A	uc001oey.2	+	19	3211	c.3211G>A	c.(3211-3213)GTC>ATC	p.V1071I	PCNXL3_uc009yqn.2_Missense_Mutation_p.V31I|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1071	Helical; (Potential).					integral to membrane					0						CGCCAGCACCGTCTTTATTGC	0.627		NA									OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	14					0	0	0	0
SART1	9092	broad.mit.edu	37	11	65735028	65735028	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:65735028G>A	uc001ogl.2	+	11	1492	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	467					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						GACGACACCCGAGTGGAGAAC	0.682		NA											10	20					0	0	0	0
MAP6	4135	broad.mit.edu	37	11	75298616	75298616	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:75298616G>A	uc001owu.2	-	4	1995	c.1930C>T	c.(1930-1932)CCA>TCA	p.P644S		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	644	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GGATGCTCTGGGACCATGGGA	0.517		NA											44	138					0	0	0	0
UBE4A	9354	broad.mit.edu	37	11	118243810	118243810	+	Missense_Mutation	SNP	A	A	C	rs111254610		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:118243810A>C	uc001psw.2	+	7	860	c.731A>C	c.(730-732)GAT>GCT	p.D244A	UBE4A_uc001psv.2_Missense_Mutation_p.D251A	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	244					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding	p.D251A(1)		ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GATTTTGAAGATGTAACTGAG	0.328		NA											11	24					0	0	0	0
NELL2	4753	broad.mit.edu	37	12	45170851	45170851	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:45170851C>G	uc001rog.2	-	7	1331	c.736G>C	c.(736-738)GAT>CAT	p.D246H	NELL2_uc001rof.3_Missense_Mutation_p.D245H|NELL2_uc001roh.2_Missense_Mutation_p.D246H|NELL2_uc009zkd.2_Missense_Mutation_p.D245H|NELL2_uc010skz.1_Missense_Mutation_p.D296H|NELL2_uc010sla.1_Missense_Mutation_p.D269H|NELL2_uc001roi.1_Missense_Mutation_p.D246H|NELL2_uc010slb.1_Missense_Mutation_p.D245H|NELL2_uc001roj.2_Missense_Mutation_p.D246H	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	246	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity	p.D246H(1)		skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GCTAAAATATCCTGTAGCTCC	0.378		NA											12	49					0	0	0	0
ARID2	196528	broad.mit.edu	37	12	46244616	46244616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:46244616C>T	uc001ros.1	+	15	2710	c.2710C>T	c.(2710-2712)CAG>TAG	p.Q904*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q904*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q360*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q531*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q238*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	904	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.Q904*(1)		ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCTCCCTTCTCAGCAAGTTTC	0.483		NA											16	63					0	0	0	0
PAN2	9924	broad.mit.edu	37	12	56720656	56720656	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:56720656A>T	uc001skx.2	-	7	1380	c.1007T>A	c.(1006-1008)TTT>TAT	p.F336Y	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.F336Y|PAN2_uc001sky.2_Missense_Mutation_p.F336Y	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	336					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGACACATCAAATGTCATTAG	0.557		NA											32	71					0	0	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559527	129559527	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:129559527G>T	uc009zyl.1	-	9	2521	c.2193C>A	c.(2191-2193)TTC>TTA	p.F731L	TMEM132D_uc001uia.2_Missense_Mutation_p.F269L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	731	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCATCAAGGAGAAGTCTTTCC	0.473		NA											13	35					1.62e-10	1.84e-10	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184386	130184386	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:130184386T>C	uc009zyl.1	-	2	1265	c.937A>G	c.(937-939)AGA>GGA	p.R313G		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	313	Extracellular (Potential).					integral to membrane		p.R313G(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTGGAATTTCTGGAGATGGAA	0.502		NA											10	22					0	0	0	0
B3GALTL	145173	broad.mit.edu	37	13	31891811	31891811	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr13:31891811G>A	uc010aaz.2	+	13	1283	c.1173G>A	c.(1171-1173)ACG>ACA	p.T391T	B3GALTL_uc001utn.3_RNA	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	391	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		GCTACATCACGGGAGGAGGAG	0.527		NA											15	50					0	0	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21771560	21771560	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:21771560A>G	uc001wag.2	+	5	658	c.658A>G	c.(658-660)ATG>GTG	p.M220V		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	220					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGGTCTATGCATGCCTAACAG	0.403		NA											9	24					0	0	0	0
HECTD1	25831	broad.mit.edu	37	14	31598317	31598317	+	Silent	SNP	A	A	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:31598317A>C	uc001wrc.1	-	25	4749	c.4260T>G	c.(4258-4260)GCT>GCG	p.A1420A	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Silent_p.A888A	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1420	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CATGGACATCAGCTCCTGAAA	0.478		NA											3	126					0	0	0	0
FSCB	84075	broad.mit.edu	37	14	44974982	44974982	+	Silent	SNP	G	G	A	rs140508672	by1000genomes	TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:44974982G>A	uc001wvn.2	-	1	1518	c.1209C>T	c.(1207-1209)GGC>GGT	p.G403G		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	403	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTTCAAGGGCGCCCTCAGCTG	0.517		NA											20	69					0	0	0	0
ATP5S	27109	broad.mit.edu	37	14	50792426	50792426	+	Silent	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:50792426A>G	uc001wxw.1	+	5	1325	c.633A>G	c.(631-633)AAA>AAG	p.K211K	ATP5S_uc001wxx.1_3'UTR|ATP5S_uc010ant.1_Intron	NM_001003803	NP_001003803	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	211					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			ovary(1)|skin(1)	2	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		TGGAACTAAAATTACAATTGA	0.308		NA											28	55					0	0	0	0
SMOC1	64093	broad.mit.edu	37	14	70490018	70490018	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:70490018G>A	uc001xls.1	+	11	1398	c.1145G>A	c.(1144-1146)CGG>CAG	p.R382Q	SMOC1_uc001xlt.1_Missense_Mutation_p.R382Q	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	382	EF-hand 1.|1 (Potential).				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding	p.R382Q(1)		upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATTAACAAGCGGGAGATGAAG	0.542		NA											20	61					0	0	0	0
FAM161B	145483	broad.mit.edu	37	14	74413239	74413239	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:74413239G>A	uc001xpd.1	-	2	230	c.124C>T	c.(124-126)CCC>TCC	p.P42S		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						CTGGCCCTGGGCAAAACCAGC	0.507		NA											4	139					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42110413	42110413	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr15:42110413A>T	uc001zok.3	+	19	2306	c.2020A>T	c.(2020-2022)ATC>TTC	p.I674F	MAPKBP1_uc001zoj.3_Missense_Mutation_p.I668F|MAPKBP1_uc010bcj.2_Missense_Mutation_p.I175F|MAPKBP1_uc010bci.2_Missense_Mutation_p.I668F|MAPKBP1_uc010udb.1_Missense_Mutation_p.I507F|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.I175F	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	674	WD 11.							p.I668F(1)		central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCCCTCAGGGATCTACATTGC	0.572		NA											11	49					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81592385	81592385	+	Silent	SNP	G	G	A	rs142057384		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr15:81592385G>A	uc002bgh.3	+	14	3094	c.2718G>A	c.(2716-2718)TCG>TCA	p.S906S	IL16_uc010blq.1_Silent_p.S860S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.S948S|IL16_uc002bgg.2_Silent_p.S906S|IL16_uc002bgi.1_Silent_p.S296S|IL16_uc002bgj.2_Silent_p.S400S|IL16_uc002bgk.2_Silent_p.S205S|IL16_uc002bgl.1_Silent_p.S205S|IL16_uc010unq.1_Silent_p.S205S	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	906					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TACTGTCCTCGGGGTCCCCTG	0.647		NA											3	78					0	0	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2983757	2983757	+	Silent	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr16:2983757C>T	uc002csd.2	+	6	1653	c.1290C>T	c.(1288-1290)TTC>TTT	p.F430F	FLYWCH1_uc002csb.2_Silent_p.F429F|FLYWCH1_uc002csc.2_Silent_p.F429F|FLYWCH1_uc010bsv.2_Silent_p.F105F	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	430	FLYWCH-type 3.					nucleus	DNA binding|metal ion binding				0						GGGGCAGCTTCCTGGTGTACG	0.682		NA											7	9					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	T	C	rs121912666		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	15					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579358	7579358	+	Missense_Mutation	SNP	C	C	A	rs11540654		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr17:7579358C>A	uc002gim.2	-	4	523	c.329G>T	c.(328-330)CGT>CTT	p.R110L	TP53_uc002gig.1_Missense_Mutation_p.R110L|TP53_uc002gih.2_Missense_Mutation_p.R110L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.R110L|TP53_uc010cni.1_Missense_Mutation_p.R110L|TP53_uc002gij.2_Missense_Mutation_p.R110L|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.R71L|TP53_uc010cnk.1_Missense_Mutation_p.R125L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	110	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		R -> G (in a sporadic cancer; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(24)|p.R110P(8)|p.0?(7)|p.R110fs*13(5)|p.R110C(4)|p.G59fs*23(3)|p.F109_R110delFR(2)|p.R110H(2)|p.V73fs*9(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.R110fs*18(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.R110S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGCCCAGACGGAAACCGTA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	45					0.000422831	0.000455514	1	0
GPR179	440435	broad.mit.edu	37	17	36485397	36485397	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr17:36485397C>A	uc002hpz.2	-	11	4076	c.4055G>T	c.(4054-4056)AGT>ATT	p.S1352I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1352	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGCCTCCACACTGTCCCCCGC	0.627		NA											10	44					1.59e-06	1.76e-06	1	0
DCC	1630	broad.mit.edu	37	18	50942511	50942511	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr18:50942511A>C	uc002lfe.1	+	21	3735	c.3148A>C	c.(3148-3150)ATG>CTG	p.M1050L	DCC_uc010xdr.1_Missense_Mutation_p.M878L|DCC_uc010dpf.1_Missense_Mutation_p.M685L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1050	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.M1050L(1)		skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCCTGACAAAATGGCTAATGA	0.378		NA											10	10					0	0	0	0
DOK6	220164	broad.mit.edu	37	18	67406313	67406313	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr18:67406313A>T	uc002lkl.2	+	6	902	c.712A>T	c.(712-714)ATG>TTG	p.M238L		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	238				M -> V (in Ref. 5; BAB71577).			insulin receptor binding	p.M238L(1)		upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TGAAAGATTAATGCTAGAAAT	0.443		NA											34	35					0	0	0	0
CTDP1	9150	broad.mit.edu	37	18	77489013	77489013	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr18:77489013G>C	uc002lnh.1	+	11	2671	c.2524G>C	c.(2524-2526)GAG>CAG	p.E842Q	CTDP1_uc002lni.1_Intron|CTDP1_uc010drd.1_Missense_Mutation_p.E842Q	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	842					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CAGTATGTCTGAGACAATGCC	0.592		NA											4	189					0	0	0	0
LONP1	9361	broad.mit.edu	37	19	5699115	5699115	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:5699115G>A	uc002mcx.2	-	10	1641	c.1608C>T	c.(1606-1608)ATC>ATT	p.I536I	LONP1_uc002mcy.2_Silent_p.I472I|LONP1_uc010duh.2_Silent_p.I277I|LONP1_uc010dui.2_Silent_p.I520I|LONP1_uc002mcz.2_Silent_p.I340I	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	536					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GGGCGCGGGCGATGGAGCGAG	0.632		NA											17	71					0	0	0	0
FKBP8	23770	broad.mit.edu	37	19	18649084	18649084	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:18649084G>A	uc002njk.1	-	5	824	c.711C>T	c.(709-711)TTC>TTT	p.F237F	FKBP8_uc002nji.1_Silent_p.F75F|FKBP8_uc010xqi.1_Silent_p.F266F|FKBP8_uc002njj.1_Silent_p.F238F|FKBP8_uc002njl.1_Silent_p.F238F|FKBP8_uc002njm.1_Silent_p.F237F|FKBP8_uc010ebr.1_Silent_p.F76F|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	237	TPR 1.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						CGGCCAGGACGAAGTCCGCCC	0.667		NA											5	68					0	0	0	0
ZFP36	7538	broad.mit.edu	37	19	39898771	39898771	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:39898771G>A	uc002olh.1	+	2	471	c.413G>A	c.(412-414)CGC>CAC	p.R138H	ZFP36_uc010egn.1_Missense_Mutation_p.A11T	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	138					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGGCCAATCGCCACCCCAAA	0.612		NA											37	93					0	0	0	0
DHX34	9704	broad.mit.edu	37	19	47856424	47856424	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:47856424A>G	uc010xyn.1	+	2	478	c.137A>G	c.(136-138)GAA>GGA	p.E46G	DHX34_uc010elc.1_Missense_Mutation_p.E46G	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	46						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TTCTTCCGTGAAGAGGATTAC	0.537		NA											17	40					0	0	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55605735	55605735	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:55605735C>T	uc002qix.2	-	13	1677	c.1661G>A	c.(1660-1662)CGC>CAC	p.R554H	PPP1R12C_uc010yfs.1_Missense_Mutation_p.R480H|PPP1R12C_uc002qiy.2_Missense_Mutation_p.R553H	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	554						cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCGAGACTGGCGCATGAGACG	0.398		NA											12	50					0	0	0	0
SIX2	10736	broad.mit.edu	37	2	45233324	45233324	+	Silent	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:45233324C>T	uc002ruo.2	-	2	1154	c.861G>A	c.(859-861)GTG>GTA	p.V287V	SIX2_uc002rup.2_Silent_p.V289V	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	287						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCCCAGGTCCACGAGGTTGG	0.642		NA											13	56					0	0	0	0
APLF	200558	broad.mit.edu	37	2	68729908	68729908	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:68729908C>T	uc002sep.2	+	3	387	c.214C>T	c.(214-216)CTC>TTC	p.L72F	APLF_uc010fdf.2_Missense_Mutation_p.L48F	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	72	FHA-like.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						GAAGAGTCAGCTCTTACCATT	0.294		NA											31	76					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136546023	136546023	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:136546023G>A	uc002tuu.1	-	17	5666	c.5655C>T	c.(5653-5655)TAC>TAT	p.Y1885Y		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1885	Helical; (Potential).				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		AAAAGAGAACGTACAAAGCTG	0.522		NA											31	146					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141946119	141946119	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:141946119C>T	uc002tvj.1	-	7	1856	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	295	Extracellular (Potential).|LDL-receptor class B 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATAGAGATTTCGAGTGAGCCA	0.408		NA								TSP Lung(27;0.18)			13	26					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216298182	216298182	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:216298182C>T	uc002vfa.2	-	3	546	c.280G>A	c.(280-282)GAA>AAA	p.E94K	FN1_uc002vfb.2_Missense_Mutation_p.E94K|FN1_uc002vfc.2_Missense_Mutation_p.E94K|FN1_uc002vfd.2_Missense_Mutation_p.E94K|FN1_uc002vfe.2_Missense_Mutation_p.E94K|FN1_uc002vff.2_Missense_Mutation_p.E94K|FN1_uc002vfg.2_Missense_Mutation_p.E94K|FN1_uc002vfh.2_Missense_Mutation_p.E94K|FN1_uc002vfi.2_Missense_Mutation_p.E94K|FN1_uc002vfj.2_Missense_Mutation_p.E94K|FN1_uc002vfl.2_Missense_Mutation_p.E94K	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	94	Fibrin- and heparin-binding 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAGTCTCTTCAGCTGAGGGG	0.468		NA											10	32					0	0	0	0
KCNB1	3745	broad.mit.edu	37	20	47991218	47991218	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr20:47991218G>A	uc002xur.1	-	2	1043	c.879C>T	c.(877-879)CGC>CGT	p.R293R	KCNB1_uc002xus.1_Silent_p.R293R	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	293					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGACCACGCGGCGGACATTCT	0.537		NA											20	34					0	0	0	0
STAB1	23166	broad.mit.edu	37	3	52553341	52553341	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:52553341G>A	uc003dej.2	+	49	5170	c.5096G>A	c.(5095-5097)GGC>GAC	p.G1699D	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1699	Extracellular (Potential).|FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.G1699D(1)		large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCGTGAACGGCATCCTGCAC	0.642		NA											63	76					0	0	0	0
ARF4	378	broad.mit.edu	37	3	57569702	57569702	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:57569702T>C	uc003dix.3	-	3	529	c.181A>G	c.(181-183)ATT>GTT	p.I61V	ARF4_uc003diy.3_RNA|ARF4_uc010hnd.2_Missense_Mutation_p.I34V|ARF4_uc003diz.3_Intron	NM_001660	NP_001651	P18085	ARF4_HUMAN	ADP-ribosylation factor 4	61					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus	GTP binding|GTPase activity	p.I61V(1)		upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0449)|Kidney(284;0.0561)		GTGAAACAAATGTTCTTATAT	0.353		NA											26	35					0	0	0	0
GPR149	344758	broad.mit.edu	37	3	154055685	154055685	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:154055685C>T	uc003faa.2	-	4	2099	c.1999G>A	c.(1999-2001)GGG>AGG	p.G667R		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	667	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCTGTTTCCCCTAGGTCACAT	0.438		NA											4	143					0	0	0	0
GABRA4	2557	broad.mit.edu	37	4	46930431	46930431	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:46930431G>A	uc003gxg.2	-	9	1615	c.1476C>T	c.(1474-1476)ACC>ACT	p.T492T		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	492	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TAGCCCCTATGGTATTAACTG	0.473		NA											16	77					0	0	0	0
LPHN3	23284	broad.mit.edu	37	4	62598970	62598970	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:62598970A>T	uc010ihh.2	+	5	1066	c.893A>T	c.(892-894)GAA>GTA	p.E298V	LPHN3_uc003hcq.3_Missense_Mutation_p.E298V|LPHN3_uc010ihg.1_Missense_Mutation_p.E366V|LPHN3_uc003hcs.1_Missense_Mutation_p.E127V	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	298	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CTACGGATCGAAGGAACATGG	0.393		NA											8	37					0	0	0	0
UGT2B11	10720	broad.mit.edu	37	4	70071211	70071211	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:70071211C>G	uc003heh.2	-	4	1086	c.1077G>C	c.(1075-1077)CAG>CAC	p.Q359H	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	359					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GAAGGTCATTCTGGGGTATCC	0.373		NA											7	127					0	0	0	0
CDS1	1040	broad.mit.edu	37	4	85566477	85566477	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:85566477A>T	uc011ccv.1	+	12	1753	c.1255A>T	c.(1255-1257)AGG>TGG	p.R419W	CDS1_uc010ike.1_3'UTR	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	419					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		AAGTTTTATAAGGTACTTTTA	0.328		NA											29	30					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175897355	175897355	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:175897355G>T	uc003iuc.2	+	5	1349	c.679G>T	c.(679-681)GTT>TTT	p.V227F	ADAM29_uc003iud.2_Missense_Mutation_p.V227F|ADAM29_uc010irr.2_Missense_Mutation_p.V227F|ADAM29_uc011cki.1_Missense_Mutation_p.V227F	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	227	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GGATCTATATGTTATTGTTAA	0.338		NA											23	42					1.11e-12	1.26e-12	1	0
FAT1	2195	broad.mit.edu	37	4	187518254	187518254	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:187518254C>T	uc003izf.2	-	25	12628	c.12440G>A	c.(12439-12441)GGC>GAC	p.G4147D	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Missense_Mutation_p.G38D	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4147	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGATAGGAGCCGTGCGTGTT	0.587		NA								HNSCC(5;0.00058)			9	16					0	0	0	0
ANKH	56172	broad.mit.edu	37	5	14716914	14716914	+	Missense_Mutation	SNP	C	C	T	rs148228793		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr5:14716914C>T	uc003jfm.3	-	9	1373	c.1042G>A	c.(1042-1044)GTG>ATG	p.V348M	ANKH_uc003jfl.3_Missense_Mutation_p.V61M	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	348	Extracellular (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	p.V348M(1)		upper_aerodigestive_tract(1)	1						TTCTCAGACACGTTGGGTGTC	0.463		NA											8	23					0	0	0	0
HMGCR	3156	broad.mit.edu	37	5	74655134	74655134	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr5:74655134A>G	uc003kdp.2	+	17	2453	c.2297A>G	c.(2296-2298)CAG>CGG	p.Q766R	HMGCR_uc011cst.1_Missense_Mutation_p.Q786R|HMGCR_uc003kdq.2_Missense_Mutation_p.Q713R|HMGCR_uc010izo.2_Missense_Mutation_p.Q89R|HMGCR_uc010izp.2_Intron	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	766	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GCCTGTGGACAGGTGAGCTCT	0.453		NA											12	33					0	0	0	0
CDYL	9425	broad.mit.edu	37	6	4935984	4935984	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:4935984G>A	uc003mwi.2	+	5	1220	c.1089G>A	c.(1087-1089)GAG>GAA	p.E363E	CDYL_uc003mwj.2_Silent_p.E309E|CDYL_uc003mwk.2_Silent_p.E74E|CDYL_uc011dhx.1_Silent_p.E177E|CDYL_uc011dhy.1_Silent_p.E177E	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	363					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		AGTCCTCAGAGAATAACTCAC	0.532		NA											23	70					0	0	0	0
GCM2	9247	broad.mit.edu	37	6	10874807	10874807	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:10874807G>A	uc003mzn.3	-	5	1014	c.942C>T	c.(940-942)GTC>GTT	p.V314V	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	314					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TGTATGAATTGACATTACATT	0.428		NA											52	131					0	0	0	0
HLA-A	3105	broad.mit.edu	37	6	29910349	29910349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:29910349C>T	uc003nol.2	+	1	19	c.19C>T	c.(19-21)CGA>TGA	p.R7*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Nonsense_Mutation_p.R7*|HLA-A_uc003noo.2_Nonsense_Mutation_p.R7*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.R7*|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_5'Flank|HLA-A_uc011dmc.1_5'Flank|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	7					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CATGGCGCCCCGAACCCTCCT	0.677		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			11	33					0	0	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778484	31778484	+	Silent	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:31778484G>A	uc003nxh.2	-	2	1449	c.1266C>T	c.(1264-1266)ATC>ATT	p.I422I	HSPA1L_uc010jte.2_Silent_p.I422I	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	422					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						GCTTGGTGGGGATGGTGGAGT	0.597		NA											23	68					0	0	0	0
RSPH9	221421	broad.mit.edu	37	6	43638533	43638533	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:43638533G>T	uc003ovw.1	+	5	704	c.678G>T	c.(676-678)TGG>TGT	p.W226C	RSPH9_uc003ovx.1_Nonsense_Mutation_p.E244*	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	226					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton		p.W226C(1)		upper_aerodigestive_tract(1)|skin(1)	2						CAGGGTCCTGGAGCATCCAGA	0.642		NA							Kartagener_syndrome				6	51					7.48e-07	8.34e-07	1	0
WASF1	8936	broad.mit.edu	37	6	110423257	110423257	+	Silent	SNP	T	T	G			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:110423257T>G	uc003ptv.1	-	10	1893	c.1056A>C	c.(1054-1056)GTA>GTC	p.V352V	WASF1_uc003ptw.1_Silent_p.V352V|WASF1_uc003ptx.1_Silent_p.V352V|WASF1_uc003pty.1_Silent_p.V352V	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	352	Poly-Pro.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GTGGGGGAGGTACTGGAGGGG	0.572		NA											8	33					0	0	0	0
ETV1	2115	broad.mit.edu	37	7	13935510	13935510	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:13935510T>C	uc011jxq.1	-	14	2154	c.1415A>G	c.(1414-1416)AAC>AGC	p.N472S	ETV1_uc011jxn.1_Missense_Mutation_p.N432S|ETV1_uc011jxo.1_Missense_Mutation_p.N369S|ETV1_uc011jxp.1_Missense_Mutation_p.N414S|ETV1_uc003ssw.3_Missense_Mutation_p.N449S|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.N454S|ETV1_uc011jxs.1_Missense_Mutation_p.N454S	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	472					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GTAGCCTTCGTTGTAGGGGTG	0.483		NA	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								6	20					0	0	0	0
TMEM195	392636	broad.mit.edu	37	7	15599868	15599868	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:15599868A>T	uc003stb.1	-	2	325	c.155T>A	c.(154-156)CTG>CAG	p.L52Q		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	52	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						AAGTTCAAGCAGCATCAAAGA	0.378		NA											18	47					0	0	0	0
ELMO1	9844	broad.mit.edu	37	7	37264524	37264524	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:37264524G>A	uc003tfk.1	-	9	968	c.661C>T	c.(661-663)CAG>TAG	p.Q221*	ELMO1_uc011kbc.1_Nonsense_Mutation_p.Q125*|ELMO1_uc010kxg.1_Nonsense_Mutation_p.Q221*	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	221					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding	p.Q221*(1)		ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GTGATCTCCTGCGCCACTTTC	0.532		NA											13	29					0	0	0	0
EPDR1	54749	broad.mit.edu	37	7	37988572	37988572	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:37988572G>A	uc003tfp.2	+	2	779	c.760G>A	c.(760-762)GAA>AAA	p.E254K	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.E73K	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	134					cell-matrix adhesion	extracellular region	calcium ion binding	p.E254K(1)		upper_aerodigestive_tract(1)	1						CTCCACCTTTGAAGACCAGTA	0.512		NA											15	26					0	0	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508605	106508605	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:106508605C>T	uc003vdv.3	+	2	684	c.599C>T	c.(598-600)CCG>CTG	p.P200L	PIK3CG_uc003vdu.2_Missense_Mutation_p.P200L|PIK3CG_uc003vdw.2_Missense_Mutation_p.P200L	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	200					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GCCATGCACCCGTGGGTGACG	0.622		NA											15	50					0	0	0	0
GCC1	79571	broad.mit.edu	37	7	127223255	127223255	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:127223255C>T	uc003vma.2	-	2	1559	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	381	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TTGGCTTTCTCGTAGGTGCCT	0.547		NA											32	92					0	0	0	0
RB1CC1	9821	broad.mit.edu	37	8	53573780	53573780	+	Missense_Mutation	SNP	G	G	A	rs151174558		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr8:53573780G>A	uc003xre.3	-	10	1978	c.1420C>T	c.(1420-1422)CGC>TGC	p.R474C	RB1CC1_uc003xrf.3_Missense_Mutation_p.R474C	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	474					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding	p.R474C(1)		ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ATTACGAGGCGGAGCAAAGCT	0.378		NA											16	66					0	0	0	0
EPPK1	83481	broad.mit.edu	37	8	144944533	144944533	+	Silent	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr8:144944533C>T	uc003zaa.1	-	1	2902	c.2889G>A	c.(2887-2889)CTG>CTA	p.L963L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	963	Plectin 18.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCCTCCAGCAGGGCCAGGG	0.716		NA											3	12					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144993862	144993862	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr8:144993862C>T	uc003zaf.1	-	32	10708	c.10538G>A	c.(10537-10539)CGC>CAC	p.R3513H	PLEC_uc003zab.1_Missense_Mutation_p.R3376H|PLEC_uc003zac.1_Missense_Mutation_p.R3380H|PLEC_uc003zad.2_Missense_Mutation_p.R3376H|PLEC_uc003zae.1_Missense_Mutation_p.R3344H|PLEC_uc003zag.1_Missense_Mutation_p.R3354H|PLEC_uc003zah.2_Missense_Mutation_p.R3362H|PLEC_uc003zaj.2_Missense_Mutation_p.R3403H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3513	Plectin 12.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CAGGCCCCGGCGCATGGCCTC	0.687		NA											12	27					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971108	21971108	+	Missense_Mutation	SNP	C	C	T	rs11552822		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr9:21971108C>T	uc003zpk.2	-	2	462	c.250G>A	c.(250-252)GAC>AAC	p.D84N	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.R139Q	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	84	ANK 3.		D -> E (in a bladder tumor).|D -> N (in an esophagus, a head and neck and a lung tumor).|D -> H (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.D84Y(9)|p.D84V(4)|p.D84N(3)|p.D84G(2)|p.D84fs*63(2)|p.D84H(2)|p.H83fs*2(2)|p.D84_F90del(1)|p.D84D(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.D84fs*0(1)|p.E61_L94del(1)|p.D84fs*36(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGGCAGCGTCGTGCACGGGT	0.741	D84Y(LK2_LUNG)|D84Y(DU145_PROSTATE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			4	5					0	0	0	0
ZNF510	22869	broad.mit.edu	37	9	99522150	99522150	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr9:99522150G>C	uc004awn.1	-	6	1151	c.962C>G	c.(961-963)TCA>TGA	p.S321*	ZNF510_uc004awo.1_Nonsense_Mutation_p.S321*	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTCCACAGTTGACTTCTCAAA	0.358		NA											29	67					0	0	0	0
CXorf22	170063	broad.mit.edu	37	X	35993984	35993984	+	Silent	SNP	C	C	A	rs138251686		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chrX:35993984C>A	uc004ddj.2	+	15	2726	c.2667C>A	c.(2665-2667)CCC>CCA	p.P889P	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	889										large_intestine(1)|lung(1)|ovary(1)	3						AATGGCAACCCGTAAACACAG	0.348		NA											22	38					7.88e-14	9.05e-14	1	0
MED14	9282	broad.mit.edu	37	X	40511065	40511065	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chrX:40511065C>T	uc004dex.3	-	31	4498	c.4358G>A	c.(4357-4359)CGT>CAT	p.R1453H		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1453					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						TGTCTATGGACGCCCACCAGG	0.388		NA											3	3					0	0	0	0
POLR3C	10623	broad.mit.edu	37	1	145608112	145608113	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:145608112_145608113insA	uc001eoh.2	-	4	745_746	c.584_585insT	c.(583-585)TTGfs	p.L195fs	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Frame_Shift_Ins_p.L208fs|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Frame_Shift_Ins_p.L195fs	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	195					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CCTTACCTATCAAGCTGAGTTT	0.411		NA											23	65	---	---	---	---	NA	NA	NA	NA
CR1	1378	broad.mit.edu	37	1	207741172	207741172	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:207741172delT	uc001hfy.2	+	17	2746	c.2606delT	c.(2605-2607)ATCfs	p.I869fs	CR1_uc009xcl.1_Frame_Shift_Del_p.I419fs|CR1_uc001hfx.2_Frame_Shift_Del_p.I1319fs|CR1_uc009xck.1_Frame_Shift_Del_p.I419fs	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	869	Extracellular (Potential).|Sushi 14.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTTCTAGAAATCTTTTGTCCA	0.408		NA											18	47	---	---	---	---	NA	NA	NA	NA
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:113704096_113704098delCTG	uc001tuw.2	+	4	646_648	c.349_351delCTG	c.(349-351)CTGdel	p.L122del	TPCN1_uc001tux.2_In_Frame_Del_p.L194del|TPCN1_uc010syt.1_In_Frame_Del_p.L54del	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	122	Helical; Name=S1 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						GGCCACGGCCCTGCTGCTGCTGC	0.64		NA											8	413	---	---	---	---	NA	NA	NA	NA
MGA	23269	broad.mit.edu	37	15	42003295	42003297	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr15:42003295_42003297delCAT	uc001zog.1	+	8	2923_2925	c.2832_2834delCAT	c.(2830-2835)GGCATC>GGC	p.I946del	MGA_uc010ucy.1_In_Frame_Del_p.I946del|MGA_uc010ucz.1_In_Frame_Del_p.I946del	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	946						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ATTCTTCAGGCATCATCTCAGAA	0.384		NA											48	93	---	---	---	---	NA	NA	NA	NA
COL21A1	81578	broad.mit.edu	37	6	56047356	56047357	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:56047356_56047357delAC	uc003pcs.2	-	2	292_293	c.60_61delGT	c.(58-63)GTGTTAfs	p.V20fs	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Frame_Shift_Del_p.V20fs|COL21A1_uc003pcu.1_Frame_Shift_Del_p.V20fs	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	20_21					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCTTCAGCTAACACAGAATTCT	0.347		NA											6	9	---	---	---	---	NA	NA	NA	NA