Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CELSR2	1952	broad.mit.edu	37	1	109794178	109794178	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr1:109794178G>A	uc001dxa.3	+	1	1538	c.1477G>A	c.(1477-1479)GTA>ATA	p.V493I		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	493	Cadherin 3.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTTGGTGACAGTACAGGTCCT	0.567		NA											4	183					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152286334	152286334	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr1:152286334C>T	uc001ezu.1	-	3	1064	c.1028G>A	c.(1027-1029)AGA>AAA	p.R343K	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	343	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGACTGGCTCTGTCTTCATC	0.562		NA							Ichthyosis				10	238					0	0	0	0
CFHR2	3080	broad.mit.edu	37	1	196918742	196918742	+	Silent	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr1:196918742C>T	uc001gtq.1	+	2	293	c.216C>T	c.(214-216)TGC>TGT	p.C72C	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	72	Sushi 1.					extracellular region				skin(2)|ovary(1)	3						GCATAACGTGCGCAGAAGAAG	0.408		NA											4	40					0	0	0	0
CAMK1D	57118	broad.mit.edu	37	10	12867572	12867572	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:12867572C>G	uc001ilo.2	+	10	1157	c.922C>G	c.(922-924)CAA>GAA	p.Q308E	CAMK1D_uc001iln.2_Missense_Mutation_p.Q308E	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	308	Autoinhibitory domain (By similarity).|Calmodulin-binding (By similarity).					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		GAAATTTCAGCAAGCATTTAA	0.413		NA											5	80					0	0	0	0
PKD2L1	9033	broad.mit.edu	37	10	102056008	102056008	+	Silent	SNP	G	G	C			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:102056008G>C	uc001kqx.1	-	7	1610	c.1227C>G	c.(1225-1227)CTC>CTG	p.L409L	PKD2L1_uc009xwm.1_Silent_p.L362L	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	409	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		GATTCACCTCGAGGGTTCGGA	0.542		NA											3	28					0	0	0	0
SUFU	51684	broad.mit.edu	37	10	104359280	104359280	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:104359280G>A	uc001kvy.1	+	8	1147	c.1001G>A	c.(1000-1002)GGC>GAC	p.G334D	SUFU_uc001kvw.1_Missense_Mutation_p.G334D|SUFU_uc001kvx.2_Missense_Mutation_p.G334D|SUFU_uc009xxe.1_RNA|SUFU_uc009xxf.1_RNA	NM_016169	NP_057253	Q9UMX1	SUFU_HUMAN	suppressor of fused	334					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		CGGCAGAATGGCCTCGCCCAC	0.582		NA	D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation				6	51					0	0	0	0
TRIM8	81603	broad.mit.edu	37	10	104415877	104415877	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:104415877G>A	uc001kvz.2	+	4	1038	c.915G>A	c.(913-915)GTG>GTA	p.V305V		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	305						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCAAGTCTGTGAAAATCCTGA	0.637		NA											5	209					0	0	0	0
PATL1	219988	broad.mit.edu	37	11	59420024	59420024	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr11:59420024C>T	uc001noe.3	-	11	1482	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	PATL1_uc009yms.1_Missense_Mutation_p.E417K|PATL1_uc010rkw.1_Missense_Mutation_p.E152K	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	447	Region H.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1						TGTATTTCTTCAGCAGCTGAC	0.458		NA											4	62					0	0	0	0
C11orf53	341032	broad.mit.edu	37	11	111154935	111154935	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr11:111154935G>A	uc001plc.2	+	3	289	c.142G>A	c.(142-144)GCA>ACA	p.A48T		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	48											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		TGAGTCCTCCGCAGGGCAGAG	0.582		NA											7	178					0	0	0	0
ESR2	2100	broad.mit.edu	37	14	64746775	64746775	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr14:64746775G>A	uc001xha.1	-	3	927	c.459C>T	c.(457-459)AGC>AGT	p.S153S	ESR2_uc001xgu.2_Silent_p.S153S|ESR2_uc001xgv.2_Silent_p.S153S|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Silent_p.S153S|ESR2_uc001xgy.1_Silent_p.S153S|ESR2_uc001xgz.1_Silent_p.S153S|ESR2_uc010aqb.1_Intron|ESR2_uc010aqc.1_Silent_p.S153S	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	153	NR C4-type.|Nuclear receptor.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	ATGCGTAATCGCTGCAGACAG	0.473		NA											12	207					0	0	0	0
GALNT1	2589	broad.mit.edu	37	18	33283589	33283589	+	Silent	SNP	C	C	G			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr18:33283589C>G	uc010dmu.2	+	11	1568	c.1515C>G	c.(1513-1515)CTC>CTG	p.L505L	GALNT1_uc002kyz.3_Silent_p.L445L|GALNT1_uc002kzb.2_Silent_p.L505L	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	505	Lumenal (Potential).|Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GCAACCAACTCTGGGAGTATG	0.373		NA											4	50					0	0	0	0
NOVA2	4858	broad.mit.edu	37	19	46444042	46444042	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr19:46444042G>A	uc002pdv.2	-	4	606	c.558C>T	c.(556-558)CCC>CCT	p.P186P		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	186	KH 2.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		GCACCTGCTCGGGCTCGCCGC	0.632		NA											3	34					0	0	0	0
ATAD2B	54454	broad.mit.edu	37	2	24046267	24046267	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:24046267G>A	uc002rek.3	-	16	2286	c.1992C>T	c.(1990-1992)TCC>TCT	p.S664S	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rej.3_5'UTR	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	664							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCACGTTGGGAAGCAGGCA	0.453		NA											3	28					0	0	0	0
C2orf16	84226	broad.mit.edu	37	2	27804893	27804893	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:27804893G>A	uc002rkz.3	+	1	5505	c.5454G>A	c.(5452-5454)TTG>TTA	p.L1818L	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1818	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACAGTCTCTTGGAGAGGAGCC	0.537		NA											6	104					0	0	0	0
RGPD4	285190	broad.mit.edu	37	2	108488636	108488636	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:108488636A>T	uc010ywk.1	+	20	4258	c.4176A>T	c.(4174-4176)CAA>CAT	p.Q1392H	RGPD4_uc002tdu.2_Missense_Mutation_p.Q579H|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1392	RanBD1 2.				intracellular transport		binding			skin(2)	2						ATAATAAGCAAGTTCGTATAG	0.363		NA											6	246					0	0	0	0
CRYGA	1418	broad.mit.edu	37	2	209025578	209025578	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:209025578C>T	uc002vcq.3	-	3	492	c.475G>A	c.(475-477)GGT>AGT	p.G159S		NM_014617	NP_055432	P11844	CRGA_HUMAN	crystallin, gamma A	159	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GCATCTGCACCCCCCCAGTCG	0.537		NA											3	87					0	0	0	0
MAPK1	5594	broad.mit.edu	37	22	22127164	22127164	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:22127164C>T	uc002zvn.2	-	7	1204	c.964G>A	c.(964-966)GAG>AAG	p.E322K	MAPK1_uc002zvo.2_Missense_Mutation_p.E322K|MAPK1_uc010gtk.1_Missense_Mutation_p.E278K	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478		NA											3	45					0	0	0	0
SLC2A11	66035	broad.mit.edu	37	22	24204324	24204324	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:24204324G>A	uc002zyn.3	+	2	154	c.55G>A	c.(55-57)GCT>ACT	p.A19T	SLC2A11_uc002zyl.1_Missense_Mutation_p.A26T|SLC2A11_uc002zym.3_Missense_Mutation_p.A26T|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Missense_Mutation_p.A26T|SLC2A11_uc011ajd.1_Missense_Mutation_p.A13T|SLC2A11_uc002zyp.3_Missense_Mutation_p.A22T	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	19	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						GACCATCTGCGCTGCCGGCAT	0.557		NA											4	156					0	0	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39387498	39387498	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:39387498G>A	uc003awo.1	+	6	939	c.885G>A	c.(883-885)GCG>GCA	p.A295A	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Silent_p.A270A|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	295					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding	p.A295V(1)		ovary(1)	1	Melanoma(58;0.04)					AAGTGCGTGCGTTCCTTCAGG	0.577		NA											5	105					0	0	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283601	40283601	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:40283601G>C	uc003ayg.2	-	2	403	c.152C>G	c.(151-153)TCA>TGA	p.S51*		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	51	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CATAATCTCTGAGAGAGAAAT	0.418		NA											3	126					0	0	0	0
CCR1	1230	broad.mit.edu	37	3	46244880	46244880	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr3:46244880G>A	uc003cph.1	-	2	996	c.925C>T	c.(925-927)CGG>TGG	p.R309W	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	309	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AGGTACTTCCGGAACCTCTCA	0.587		NA											3	25					0	0	0	0
C3orf38	285237	broad.mit.edu	37	3	88199220	88199220	+	Silent	SNP	C	C	G			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr3:88199220C>G	uc003dqw.2	+	2	329	c.18C>G	c.(16-18)CTC>CTG	p.L6L	CGGBP1_uc003dqu.2_5'Flank	NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	6					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TGTCGGGACTCAGCTTTTCAG	0.617		NA											3	24					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71492944	71492944	+	Silent	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr5:71492944G>A	uc003kbw.3	+	5	4003	c.3762G>A	c.(3760-3762)TCG>TCA	p.S1254S	MAP1B_uc010iyw.1_Silent_p.S1271S|MAP1B_uc010iyx.1_Silent_p.S1128S|MAP1B_uc010iyy.1_Silent_p.S1128S	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1254						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCAGCCCATCGAAGAGCCCGT	0.493		NA											5	44					0	0	0	0
AFF4	27125	broad.mit.edu	37	5	132232314	132232314	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr5:132232314C>T	uc003kyd.2	-	11	2416	c.2008G>A	c.(2008-2010)GAG>AAG	p.E670K	AFF4_uc011cxk.1_Missense_Mutation_p.E348K|AFF4_uc003kye.1_Missense_Mutation_p.E670K	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	670					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTATTGCTCTCGGGGTACTTA	0.443		NA											4	55					0	0	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723793	140723793	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr5:140723793C>T	uc003ljm.1	+	1	193	c.193C>T	c.(193-195)CGC>TGC	p.R65C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.R65C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTCCGCATCGTCTC	0.617		NA									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	136					0	0	0	0
ASF1A	25842	broad.mit.edu	37	6	119226832	119226832	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr6:119226832C>G	uc011ebn.1	+	3	578	c.241C>G	c.(241-243)CCA>GCA	p.P81A		NM_014034	NP_054753	Q9Y294	ASF1A_HUMAN	ASF1 anti-silencing function 1 homolog A	81	Interaction with histone H3, CHAF1B, and HIRA.				chromatin modification|DNA repair|loss of chromatin silencing|nucleosome assembly|transcription, DNA-dependent	chromatin remodeling complex	chromatin binding|histone binding				0		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0633)|OV - Ovarian serous cystadenocarcinoma(136;0.188)		TGCACCTAATCCAGGACTCAT	0.393		NA											3	116					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82581315	82581315	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr7:82581315C>G	uc003uhx.2	-	5	9243	c.8954G>C	c.(8953-8955)AGA>ACA	p.R2985T	PCLO_uc003uhv.2_Missense_Mutation_p.R2985T|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2916					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCCAATCCCTCTATAACCATA	0.423		NA											7	173					0	0	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490605	141490605	+	Silent	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr7:141490605C>T	uc003vwr.1	+	1	589	c.444C>T	c.(442-444)TTC>TTT	p.F148F		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	148	Helical; Name=4; (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					GCTTAACATTCTATCATCCTC	0.433		NA											4	24					0	0	0	0
CPA6	57094	broad.mit.edu	37	8	68423859	68423859	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr8:68423859C>G	uc003xxq.3	-	4	605	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	CPA6_uc003xxr.3_5'UTR|CPA6_uc003xxs.2_Missense_Mutation_p.E117Q	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	117					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			CTTCCCTTCTCCAGTGTTTTC	0.388		NA											6	198					0	0	0	0
FAM189A2	9413	broad.mit.edu	37	9	71992331	71992331	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:71992331G>A	uc010mon.1	+	5	402	c.298G>A	c.(298-300)GTC>ATC	p.V100I	FAM189A2_uc004ahg.2_Missense_Mutation_p.V100I|FAM189A2_uc010moo.1_5'UTR	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61 precursor	100	Helical; (Potential).					integral to membrane					0						GACCACCACCGTCTGCTTGGT	0.532		NA											7	55					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77354692	77354692	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:77354692G>A	uc004ajl.1	-	34	5672	c.5434C>T	c.(5434-5436)CGG>TGG	p.R1812W	TRPM6_uc004ajk.1_Missense_Mutation_p.R1807W|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.R763W|TRPM6_uc010mpd.1_Missense_Mutation_p.R645W|TRPM6_uc010mpe.1_Missense_Mutation_p.R359W|TRPM6_uc004ajj.1_Missense_Mutation_p.R768W	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1812	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGCCATGTCCGCACAACCTCA	0.488		NA											5	183					0	0	0	0
KIAA0649	9858	broad.mit.edu	37	9	138379027	138379027	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:138379027C>T	uc004cfr.1	+	4	3220	c.2671C>T	c.(2671-2673)CGC>TGC	p.R891C		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	891						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		CGTGTGCACACGCAGCCAGAG	0.697		NA											15	57					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139413085	139413085	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:139413085G>A	uc004chz.2	-	6	1057	c.1057C>T	c.(1057-1059)CGT>TGT	p.R353C		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	353	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.R353H(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGGCCACACGGTCATGGCAG	0.652		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	16					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28518115	28518115	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr15:28518115delC	uc001zbj.2	-	8	942	c.836delG	c.(835-837)GGAfs	p.G279fs	HERC2_uc001zbl.1_5'UTR	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	279					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGGGATGCTTCCTGGCCCTTT	0.592		NA											7	62	---	---	---	---	NA	NA	NA	NA