Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
RASAL1	8437	broad.mit.edu	37	12	113552686	113552686	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr12:113552686A>G	uc001tum.1	-	13	1393	c.1100T>C	c.(1099-1101)CTG>CCG	p.L367P	RASAL1_uc010syp.1_Missense_Mutation_p.L367P|RASAL1_uc001tul.2_Missense_Mutation_p.L367P|RASAL1_uc001tun.1_Missense_Mutation_p.L367P|RASAL1_uc010syq.1_Missense_Mutation_p.L367P|RASAL1_uc001tuo.3_Missense_Mutation_p.L367P|RASAL1_uc010syr.1_Missense_Mutation_p.L367P	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	367	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						CACAGGCTTCAGGACCTCGTG	0.657		NA											4	329					0	0	0	0
AKAP11	11215	broad.mit.edu	37	13	42874583	42874583	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr13:42874583A>C	uc001uys.1	+	8	1876	c.1701A>C	c.(1699-1701)AAA>AAC	p.K567N		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	567					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTGCATTTAAAGACTTACAGA	0.323		NA											3	59					0	0	0	0
CUEDC1	404093	broad.mit.edu	37	17	55957076	55957076	+	Silent	SNP	A	A	G			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:55957076A>G	uc002ivd.1	-	3	1079	c.360T>C	c.(358-360)CCT>CCC	p.P120P	CUEDC1_uc002ive.1_Silent_p.P120P	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	120	Pro-rich.									skin(2)	2						CCGAGCTATCAGGTTCCAAAG	0.408		NA											3	99					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579566	7579566	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:7579566delC	uc002gim.2	-	4	315	c.121delG	c.(121-123)GATfs	p.D41fs	TP53_uc002gig.1_Frame_Shift_Del_p.D41fs|TP53_uc002gih.2_Frame_Shift_Del_p.D41fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.D41fs|TP53_uc010cni.1_Frame_Shift_Del_p.D41fs|TP53_uc002gij.2_Frame_Shift_Del_p.D41fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.D2fs|TP53_uc010cnk.1_Frame_Shift_Del_p.D56fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	41	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.D41fs*3(1)|p.S37fs*79(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCAAATCATCCATTGCTTGG	0.458		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	285	---	---	---	---	NA	NA	NA	NA