Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AIM1L	55057	broad.mit.edu	37	1	26663842	26663842	+	Missense_Mutation	SNP	G	G	A	rs145909949	by1000genomes	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:26663842G>A	uc001bmd.3	-	9	968	c.538C>T	c.(538-540)CGG>TGG	p.R180W	AIM1L_uc001bmf.3_Missense_Mutation_p.R71W	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	180	Beta/gamma crystallin 'Greek key' 4.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		TGGTGGCCCCGGAAGCCCTCC	0.607		NA											5	72					0	0	0	0
LCK	3932	broad.mit.edu	37	1	32740034	32740034	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:32740034C>T	uc001bux.2	+	2	242	c.104C>T	c.(103-105)ACG>ATG	p.T35M	LCK_uc001buy.2_Missense_Mutation_p.T35M|LCK_uc001buz.2_Missense_Mutation_p.T35M|LCK_uc010ohc.1_Missense_Mutation_p.T79M|LCK_uc001bva.2_Missense_Mutation_p.T35M	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	35	Interactions with CD4 and CD8 (By similarity).			T -> R (in Ref. 2; AAA59502).	activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GGCAAGGGCACGGTAAGAGGC	0.532		NA	T	TRB@	T-ALL								15	45					0	0	0	0
TMEM54	113452	broad.mit.edu	37	1	33363922	33363922	+	Splice_Site	SNP	T	T	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:33363922T>A	uc001bwi.1	-	2	131	c.17_splice	c.e2-1	p.G6_splice	TMEM54_uc001bwj.1_Splice_Site_p.G6_splice|TMEM54_uc001bwk.1_Splice_Site_p.G6_splice	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54							integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCAGGCCTCCTGTGGGGGACA	0.602		NA											15	37					0	0	0	0
PTCH2	8643	broad.mit.edu	37	1	45293182	45293182	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:45293182C>T	uc010olf.1	-	15	2275	c.2263G>A	c.(2263-2265)GCC>ACC	p.A755T	PTCH2_uc010olg.1_Missense_Mutation_p.A453T	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	755	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCAAAGAGGGCGCGTTGGGAG	0.642		NA							Basal_Cell_Nevus_syndrome				12	29					0	0	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042502	59042502	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:59042502G>A	uc001cyz.3	-	1	665	c.327C>T	c.(325-327)GAC>GAT	p.D109D		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	109	Extracellular (Potential).|Thyroglobulin type-1.				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					GGCCCTCGGGGTCGCAGTCGG	0.701		NA											4	11					0	0	0	0
PKN2	5586	broad.mit.edu	37	1	89298809	89298809	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:89298809C>T	uc001dmn.2	+	21	3062	c.2720C>T	c.(2719-2721)GCA>GTA	p.A907V	PKN2_uc010osp.1_Missense_Mutation_p.A891V|PKN2_uc010osq.1_Missense_Mutation_p.A750V|PKN2_uc009wcv.2_Missense_Mutation_p.A859V|PKN2_uc010osr.1_Missense_Mutation_p.A572V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	907	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GAGAAAGATGCAGAGGATGTA	0.318		NA											3	24					0	0	0	0
ABCA4	24	broad.mit.edu	37	1	94506793	94506793	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:94506793T>C	uc001dqh.2	-	23	3598	c.3494A>G	c.(3493-3495)AAC>AGC	p.N1165S		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1165	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCTCTGGATGTTTTTCATCTT	0.562		NA											10	53					0	0	0	0
PTPN22	26191	broad.mit.edu	37	1	114397603	114397603	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:114397603G>A	uc001eds.2	-	8	739	c.609C>T	c.(607-609)GAC>GAT	p.D203D	uc001edv.1_5'Flank|PTPN22_uc009wgq.2_Silent_p.D203D|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Silent_p.D203D|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Silent_p.D203D	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	203	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGAATAGGGTCTATAGATG	0.368		NA											29	83					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738746	176738746	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:176738746G>T	uc001gkz.2	+	16	5491	c.4327G>T	c.(4327-4329)GAA>TAA	p.E1443*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1443	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTTCTAGAAGGAAATTCTGCT	0.453		NA											11	54					1.09e-07	1.2e-07	1	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200818427	200818427	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:200818427C>T	uc001gvl.2	+	12	2833	c.2563C>T	c.(2563-2565)CCT>TCT	p.P855S	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.P844S|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.P828S	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	855						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CATGGAGAATCCTCAAGCCAA	0.413		NA											13	95					0	0	0	0
IPO9	55705	broad.mit.edu	37	1	201817629	201817629	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:201817629C>A	uc001gwz.2	+	4	471	c.421C>A	c.(421-423)CCT>ACT	p.P141T		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	141					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CTGGGACTGGCCTGAAGCTTG	0.542		NA											10	46					1.59e-06	1.74e-06	1	0
DISC1	27185	broad.mit.edu	37	1	231829916	231829916	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:231829916C>A	uc001huz.2	+	2	465	c.412C>A	c.(412-414)CCT>ACT	p.P138T	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.P127T|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.P127T|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.P127T|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.P138T|DISC1_uc010pwp.1_Missense_Mutation_p.P138T|DISC1_uc010pwq.1_Missense_Mutation_p.P138T|DISC1_uc010pwr.1_Missense_Mutation_p.P138T|DISC1_uc010pws.1_Missense_Mutation_p.P138T|DISC1_uc010pwt.1_Missense_Mutation_p.P138T|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.P138T|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.P138T|DISC1_uc010pxb.1_Missense_Mutation_p.P138T|DISC1_uc010pxc.1_Missense_Mutation_p.P138T|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.P138T|DISC1_uc009xfr.2_Missense_Mutation_p.P93T|DISC1_uc010pxf.1_Missense_Mutation_p.P138T|DISC1_uc010pxg.1_Missense_Mutation_p.P138T|DISC1_uc010pxh.1_Missense_Mutation_p.P138T|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.P138T|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.P138T|DISC1_uc010pwm.1_Missense_Mutation_p.P138T|DISC1_uc001hux.1_Missense_Mutation_p.P138T|DISC1_uc001hvc.3_Missense_Mutation_p.P138T|DISC1_uc010pwn.1_Missense_Mutation_p.P138T	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	138	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GCCGTGTGGCCCTGGGAGTGC	0.612		NA											8	23					0.00448238	0.00461075	1	0
ZNF670	93474	broad.mit.edu	37	1	247201495	247201495	+	Silent	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:247201495A>G	uc001icd.1	-	4	597	c.426T>C	c.(424-426)CAT>CAC	p.H142H	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	142	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			ATTGTTTGCAATGATATAACT	0.413		NA											41	140					0	0	0	0
OR2T12	127064	broad.mit.edu	37	1	248458349	248458349	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:248458349C>T	uc010pzj.1	-	1	532	c.532G>A	c.(532-534)GAG>AAG	p.E178K		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACGGGGGCCTCGCAGAAGAAG	0.567		NA											26	72					0	0	0	0
OR2T4	127074	broad.mit.edu	37	1	248524920	248524920	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:248524920G>T	uc001ieh.1	+	1	38	c.38G>T	c.(37-39)TGG>TTG	p.W13L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACACTGGATGGTCGGATTTC	0.483		NA											11	47					0.000151284	0.000161395	1	0
OR2G6	391211	broad.mit.edu	37	1	248685642	248685642	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:248685642C>T	uc001ien.1	+	1	695	c.695C>T	c.(694-696)GCG>GTG	p.A232V		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAATCAGCTGCGGGCCGCCAA	0.468		NA											27	70					0	0	0	0
SORCS1	114815	broad.mit.edu	37	10	108716285	108716285	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr10:108716285C>G	uc001kym.2	-	2	620	c.612G>C	c.(610-612)GAG>GAC	p.E204D	SORCS1_uc001kyl.2_Missense_Mutation_p.E204D|SORCS1_uc009xxs.2_Missense_Mutation_p.E204D|SORCS1_uc001kyn.1_Missense_Mutation_p.E204D|SORCS1_uc001kyo.2_Missense_Mutation_p.E204D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	204	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAAGCGAGCTCTCTGTGATGC	0.418		NA											17	28					0	0	0	0
BCCIP	56647	broad.mit.edu	37	10	127519144	127519144	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr10:127519144C>T	uc001ljb.3	+	4	358	c.335C>T	c.(334-336)TCA>TTA	p.S112L	BCCIP_uc001ljd.3_Missense_Mutation_p.S112L|BCCIP_uc010qui.1_Missense_Mutation_p.S112L|BCCIP_uc001ljc.3_Missense_Mutation_p.S112L|BCCIP_uc010quj.1_Intron	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	112	Interaction with BRCA2.				cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ACGGATGTTTCAGAAGACAGC	0.299		NA											15	67					0	0	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57080223	57080223	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:57080223C>A	uc001njr.2	-	4	2251	c.1939G>T	c.(1939-1941)GAG>TAG	p.E647*	TNKS1BP1_uc001njs.2_Nonsense_Mutation_p.E647*|TNKS1BP1_uc009ymd.1_Nonsense_Mutation_p.E98*	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	647	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GCCTCCTCCTCAACAGGCAGT	0.647		NA											15	31					7.93e-07	8.72e-07	1	0
DAGLA	747	broad.mit.edu	37	11	61505662	61505662	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:61505662C>T	uc001nsa.2	+	16	1750	c.1639C>T	c.(1639-1641)CGA>TGA	p.R547*		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	547	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TGTCCTGCAGCGAAGCACCAA	0.642		NA											10	39					0	0	0	0
HNRNPUL2	221092	broad.mit.edu	37	11	62488775	62488775	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:62488775G>A	uc001nuw.2	-	9	1796	c.1603C>T	c.(1603-1605)CTT>TTT	p.L535F	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	535					cell killing	nucleus	ATP binding|nucleic acid binding				0						ACCTGATCAAGAATAAAGTTC	0.428		NA											11	295					0	0	0	0
SIPA1	6494	broad.mit.edu	37	11	65417519	65417519	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:65417519G>T	uc001ofb.2	+	13	3012	c.2845G>T	c.(2845-2847)GAG>TAG	p.E949*	SIPA1_uc010rom.1_Nonsense_Mutation_p.E847*|SIPA1_uc001ofd.2_Nonsense_Mutation_p.E949*	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	949					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GCTGTCCCGAGAGGGTGAGGC	0.627		NA											19	49					1.68e-08	1.86e-08	1	0
EXPH5	23086	broad.mit.edu	37	11	108380358	108380358	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:108380358T>C	uc001pkk.2	-	6	5987	c.5876A>G	c.(5875-5877)TAT>TGT	p.Y1959C	EXPH5_uc010rvy.1_Missense_Mutation_p.Y1771C|EXPH5_uc010rvz.1_Missense_Mutation_p.Y1803C|EXPH5_uc010rwa.1_Missense_Mutation_p.Y1883C	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1959					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GTCATCCTCATAGATATTAAG	0.448		NA											47	105					0	0	0	0
OR4D5	219875	broad.mit.edu	37	11	123811134	123811134	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:123811134G>A	uc001pzk.1	+	1	811	c.811G>A	c.(811-813)GTC>ATC	p.V271I		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	271	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGACAAGGCCGTCTCTGTGCT	0.493		NA											29	79					0	0	0	0
ACRBP	84519	broad.mit.edu	37	12	6753641	6753641	+	Silent	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:6753641C>T	uc001qpu.1	-	5	654	c.606G>A	c.(604-606)GAG>GAA	p.E202E	ACRBP_uc010sfg.1_Silent_p.E169E	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	202						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CCTGCCTGTGCTCCACTCCTT	0.378		NA											17	78					0	0	0	0
PRB3	5544	broad.mit.edu	37	12	11421068	11421068	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:11421068G>A	uc001qzs.2	-	3	153	c.115C>T	c.(115-117)CGA>TGA	p.R39*	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	39	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGTGGGCGTCGTCCTTCTGGC	0.547		NA											20	69					0	0	0	0
PRB2	653247	broad.mit.edu	37	12	11545926	11545926	+	Silent	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:11545926A>G	uc010shk.1	-	3	1121	c.1086T>C	c.(1084-1086)CCT>CCC	p.P362P		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GCTTTCCTGGAGGAGATCGGG	0.612		NA											81	258					0	0	0	0
GRIN2B	2904	broad.mit.edu	37	12	13828761	13828761	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:13828761T>G	uc001rbt.2	-	4	1222	c.1043A>C	c.(1042-1044)AAT>ACT	p.N348T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	348	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAAGGACAAATTCCTCCCCTC	0.408		NA											21	80					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40681270	40681270	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:40681270A>T	uc001rmg.3	+	20	2739	c.2618A>T	c.(2617-2619)GAT>GTT	p.D873V	LRRK2_uc001rmh.1_Missense_Mutation_p.D495V	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	873					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCTAAATTTGATGAATGGACC	0.383		NA											6	61					0	0	0	0
SCYL2	55681	broad.mit.edu	37	12	100728042	100728042	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:100728042G>A	uc001thn.2	+	14	1910	c.1860G>A	c.(1858-1860)CAG>CAA	p.Q620Q	SCYL2_uc001thm.1_Silent_p.Q620Q	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	620					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						AAGAACAGCAGAAGTAAGTAG	0.338		NA											20	55					0	0	0	0
CIT	11113	broad.mit.edu	37	12	120214570	120214570	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:120214570C>T	uc001txi.1	-	14	1795	c.1742G>A	c.(1741-1743)CGG>CAG	p.R581Q	CIT_uc001txh.1_Missense_Mutation_p.R115Q|CIT_uc001txj.1_Missense_Mutation_p.R581Q	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	581	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GAGATCACTCCGTCTTCTTGC	0.448		NA											32	63					0	0	0	0
HNF1A	6927	broad.mit.edu	37	12	121432043	121432043	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:121432043G>A	uc001tzg.2	+	4	813	c.790G>A	c.(790-792)GTC>ATC	p.V264I	HNF1A_uc001tze.1_Missense_Mutation_p.V264I|HNF1A_uc001tzf.2_Missense_Mutation_p.V264I|HNF1A_uc010szn.1_Missense_Mutation_p.V264I	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	264	Homeobox; HNF1-type.|Interaction with DNA.				glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGAGGTGCGTGTCTACAACTG	0.647		NA							Hepatic_Adenoma_Familial_Clustering_of				5	10					0	0	0	0
FLT1	2321	broad.mit.edu	37	13	28880897	28880897	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:28880897C>T	uc001usb.3	-	29	4018	c.3733G>A	c.(3733-3735)GAC>AAC	p.D1245N	FLT1_uc010aap.2_Missense_Mutation_p.D250N|FLT1_uc010aaq.2_Missense_Mutation_p.D370N|FLT1_uc001usa.3_Missense_Mutation_p.D463N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1245	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTGCTGCTGTCGCCCTGGTAG	0.552		NA											12	52					0	0	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33091954	33091954	+	Silent	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:33091954G>T	uc001uuk.3	-	6	1915	c.1737C>A	c.(1735-1737)GTC>GTA	p.V579V	N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010abe.1_Intron|N4BP2L2_uc010tdz.1_Intron	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	579											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GATTATTTGTGACACAGACAC	0.413		NA											10	48					0.00829132	0.00848826	1	0
OLFM4	10562	broad.mit.edu	37	13	53616150	53616150	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:53616150G>T	uc001vhl.2	+	3	463	c.463G>T	c.(463-465)GAC>TAC	p.D155Y	OLFM4_uc001vhk.1_Missense_Mutation_p.D155Y	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	155	Potential.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CACTGAACTGGACTTCGAGCT	0.403		NA											20	70					5.26e-13	5.92e-13	1	0
GPC5	2262	broad.mit.edu	37	13	92560274	92560274	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:92560274T>C	uc010tif.1	+	6	1730	c.1364T>C	c.(1363-1365)ATA>ACA	p.I455T		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	455						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GATCCTGTGATAAATCAGATT	0.358		NA											19	27					0	0	0	0
PTGER2	5732	broad.mit.edu	37	14	52794093	52794093	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:52794093G>A	uc001wzr.2	+	2	1249	c.998G>A	c.(997-999)CGG>CAG	p.R333Q		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	333	Cytoplasmic (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CTCTGTTGTCGGATTTCATTA	0.408		NA											15	90					0	0	0	0
C14orf102	55051	broad.mit.edu	37	14	90798195	90798195	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:90798195G>T	uc001xyi.1	-	1	85	c.54C>A	c.(52-54)AGC>AGA	p.S18R	C14orf102_uc001xyj.1_5'UTR	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	18							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		CTTTCCTGGAGCTCCCGCCAT	0.592		NA											9	124					0.00448238	0.00461075	1	0
LGMN	5641	broad.mit.edu	37	14	93176022	93176022	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:93176022G>A	uc001yav.2	-	12	1341	c.1015C>T	c.(1015-1017)CTG>TTG	p.L339L	LGMN_uc001yat.2_Silent_p.L339L|LGMN_uc001yau.2_Silent_p.L339L|LGMN_uc001yaw.2_Silent_p.L339L|LGMN_uc010aul.2_Silent_p.L220L|LGMN_uc001yax.2_Silent_p.L339L|LGMN_uc001yay.2_Silent_p.L339L	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	339					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		CTCACATCCAGATGCCGCTGG	0.592		NA											37	112					0	0	0	0
C14orf129	51527	broad.mit.edu	37	14	96851862	96851862	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:96851862G>A	uc001yfj.3	+	4	406	c.261G>A	c.(259-261)GTG>GTA	p.V87V	C14orf129_uc001yfl.2_Silent_p.V87V	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	87						cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		TCTTGTAGGTGGTAGGCTATG	0.398		NA											44	93					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20559465	20559465	+	Silent	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr16:20559465C>T	uc002dhj.3	-	9	1227	c.1017G>A	c.(1015-1017)GAG>GAA	p.E339E	ACSM2B_uc002dhk.3_Silent_p.E339E|ACSM2B_uc010bwf.1_Silent_p.E339E	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	339					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GAAGAAGGGACTCCCCTCCAG	0.527		NA											42	120					0	0	0	0
TUBB3	10381	broad.mit.edu	37	16	89986164	89986164	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr16:89986164G>A	uc002fpf.2	+	1	906	c.498G>A	c.(496-498)GCG>GCA	p.A166A	MC1R_uc002fpe.3_Silent_p.A166A|TUBB3_uc010ciz.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	Error:Variant_position_missing_in_Q13509_after_alignment					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GAGCCGTTGCGGCCATCTGGG	0.647		NA											13	50					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7576852	7576852	+	Splice_Site	SNP	C	C	T	rs11575997		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:7576852C>T	uc002gim.2	-	9	1187	c.993_splice	c.e9+1	p.Q331_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.Q331_splice|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site_p.Q199_splice|TP53_uc010cng.1_Splice_Site_p.Q199_splice|TP53_uc002gii.1_Splice_Site_p.Q199_splice|TP53_uc010cnh.1_Splice_Site_p.Q331_splice|TP53_uc010cni.1_Splice_Site_p.Q331_splice|TP53_uc002gij.2_Splice_Site_p.Q331_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(7)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGACTTAGTACCTGAAGGGTG	0.458		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			37	50					0	0	0	0
TEKT3	64518	broad.mit.edu	37	17	15231310	15231310	+	Missense_Mutation	SNP	G	G	A	rs143165525	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:15231310G>A	uc002gon.2	-	4	849	c.662C>T	c.(661-663)ACG>ATG	p.T221M		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	221					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CACATTTACCGTCAGCAGTTG	0.383		NA											27	89					0	0	0	0
C17orf63	55731	broad.mit.edu	37	17	27086837	27086837	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:27086837G>A	uc002hct.1	-	3	407	c.140C>T	c.(139-141)GCG>GTG	p.A47V	C17orf63_uc010wax.1_Missense_Mutation_p.A47V|C17orf63_uc010way.1_Missense_Mutation_p.A47V|C17orf63_uc002hcw.2_Intron	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	47										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			CTTAGCATACGCATCCAATTC	0.393		NA											3	12					0	0	0	0
ACACA	31	broad.mit.edu	37	17	35600294	35600294	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:35600294C>T	uc002hnm.2	-	22	3004	c.2813G>A	c.(2812-2814)AGC>AAC	p.S938N	ACACA_uc002hnk.2_Missense_Mutation_p.S860N|ACACA_uc002hnl.2_Missense_Mutation_p.S880N|ACACA_uc002hnn.2_Missense_Mutation_p.S938N|ACACA_uc002hno.2_Missense_Mutation_p.S975N|ACACA_uc010cuz.2_Missense_Mutation_p.S938N	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	938					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TACCTGCTGGCTGGGAAACTG	0.428		NA											18	144					0	0	0	0
MAPT	4137	broad.mit.edu	37	17	44060805	44060805	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:44060805C>T	uc002ijr.3	+	6	955	c.635C>T	c.(634-636)CCG>CTG	p.P212L	MAPT_uc010dau.2_Missense_Mutation_p.P212L|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	212					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				AAAGAGAGGCCGGGGAGCAAG	0.692		NA											6	18					0	0	0	0
BRIP1	83990	broad.mit.edu	37	17	59821801	59821801	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:59821801C>A	uc002izk.1	-	15	2390	c.2249G>T	c.(2248-2250)GGA>GTA	p.G750V	BRIP1_uc002izl.1_Missense_Mutation_p.G131V	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	750					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ACCTTTCTCTCCTTTGTATTT	0.308		NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				33	115					2.29e-25	2.59e-25	1	0
HELZ	9931	broad.mit.edu	37	17	65104673	65104673	+	Silent	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:65104673C>T	uc010wqk.1	-	30	4849	c.4662G>A	c.(4660-4662)CCG>CCA	p.P1554P	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.P1553P|HELZ_uc010der.2_Silent_p.P97P	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CCCTCACTGGCGGCTGATGTA	0.562		NA											11	58					0	0	0	0
ITGB4	3691	broad.mit.edu	37	17	73725497	73725497	+	Silent	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:73725497C>T	uc002jpg.2	+	7	905	c.718C>T	c.(718-720)CTG>TTG	p.L240L	ITGB4_uc002jph.2_Silent_p.L240L|ITGB4_uc010dgo.2_Silent_p.L240L|ITGB4_uc002jpi.3_Silent_p.L240L|ITGB4_uc010dgp.1_Silent_p.L240L|ITGB4_uc002jpj.2_Silent_p.L240L|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	240	VWFA.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGATGCCATCCTGCAGACAGC	0.622		NA											10	38					0	0	0	0
HRH4	59340	broad.mit.edu	37	18	22056762	22056762	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr18:22056762G>A	uc002kvi.2	+	3	509	c.409G>A	c.(409-411)GTG>ATG	p.V137M	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	137	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TACTCTGATGGTGGCCGTTTG	0.388		NA											28	81					0	0	0	0
PMAIP1	5366	broad.mit.edu	37	18	57569917	57569917	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr18:57569917G>A	uc002lic.2	+	2	315	c.97G>A	c.(97-99)GGA>AGA	p.G33R	PMAIP1_uc002lid.2_Nonsense_Mutation_p.W83*	NM_021127	NP_066950	Q13794	APR_HUMAN	phorbol-12-myristate-13-acetate-induced protein	33	BH3.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to glucose starvation|cellular response to hypoxia|negative regulation of mitochondrial membrane potential|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of glucose metabolic process|positive regulation of protein oligomerization|positive regulation of release of cytochrome c from mitochondria|proteasomal protein catabolic process|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability|response to dsRNA|signal transduction by p53 class mediator resulting in induction of apoptosis|T cell homeostasis|virus-infected cell apoptosis	cytosol|mitochondrial outer membrane|nucleus	protein binding				0		Colorectal(73;0.0946)				CAGGAGATTTGGAGACAAACT	0.433		NA											23	49					0	0	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054997	4054997	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:4054997G>C	uc002lzh.2	-	2	309	c.234C>G	c.(232-234)GAC>GAG	p.D78E	ZBTB7A_uc002lzi.2_Missense_Mutation_p.D78E	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	78	BTB.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCTGACGAAGTCGATCTCGT	0.662		NA											5	35					0	0	0	0
TRIP10	9322	broad.mit.edu	37	19	6749986	6749986	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:6749986C>T	uc002mfs.2	+	12	1370	c.1304C>T	c.(1303-1305)CCT>CTT	p.P435L	TRIP10_uc010dux.1_Missense_Mutation_p.P379L|TRIP10_uc002mfr.2_Missense_Mutation_p.P379L|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.P198L	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	435	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						GAGAAGACACCTCAGATGGGG	0.468		NA											32	103					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11134270	11134270	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:11134270G>A	uc002mqf.3	+	20	3220	c.2936G>A	c.(2935-2937)CGA>CAA	p.R979Q	SMARCA4_uc010dxp.2_Missense_Mutation_p.R979Q|SMARCA4_uc010dxo.2_Missense_Mutation_p.R979Q|SMARCA4_uc002mqg.1_Missense_Mutation_p.R979Q|SMARCA4_uc010dxq.2_Missense_Mutation_p.R979Q|SMARCA4_uc010dxr.2_Missense_Mutation_p.R979Q|SMARCA4_uc002mqj.3_Missense_Mutation_p.R979Q|SMARCA4_uc010dxs.2_Missense_Mutation_p.R979Q|SMARCA4_uc010dxt.1_Missense_Mutation_p.R199Q|SMARCA4_uc002mqh.3_Missense_Mutation_p.R102Q|SMARCA4_uc002mqi.1_Missense_Mutation_p.R182Q	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	979					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TTGCTCCGACGACTCAAGAAG	0.577		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				8	17					0	0	0	0
CCDC151	115948	broad.mit.edu	37	19	11537572	11537572	+	Silent	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:11537572C>T	uc002mrs.2	-	5	788	c.645G>A	c.(643-645)AAG>AAA	p.K215K	CCDC151_uc002mrr.2_Silent_p.K150K|CCDC151_uc010dxz.2_Intron	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	215	Potential.									ovary(1)	1						TCATCTGGGCCTTCTCCAGGC	0.627		NA											7	25					0	0	0	0
DDX39	10212	broad.mit.edu	37	19	14521049	14521049	+	Silent	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:14521049C>A	uc010xnp.1	-	6	756	c.711G>T	c.(709-711)GTG>GTT	p.V237V	DDX39_uc002myo.2_Silent_p.V237V|DDX39_uc010dzl.2_RNA|DDX39_uc010dzm.1_Silent_p.V237V	NM_005804	NP_005795	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39	237	Helicase ATP-binding.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding				0						ACTTCCTGCACACAGGCCGGA	0.632		NA											14	52					6.72e-11	7.53e-11	1	0
ABHD8	79575	broad.mit.edu	37	19	17411760	17411760	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:17411760G>A	uc002ngb.3	-	2	906	c.666C>T	c.(664-666)GCC>GCT	p.A222A		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	222							hydrolase activity				0						TGTAGGCTGCGGCCACCTGGG	0.602		NA											5	90					0	0	0	0
FXYD5	53827	broad.mit.edu	37	19	35657174	35657174	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:35657174C>T	uc002nyg.1	+	8	519	c.433C>T	c.(433-435)CGG>TGG	p.R145W	FXYD5_uc010xsq.1_Missense_Mutation_p.R145W|FXYD5_uc002nyh.1_Missense_Mutation_p.R145W|FXYD5_uc002nyi.1_Missense_Mutation_p.R82W|FXYD5_uc002nyj.1_5'Flank	NM_014164	NP_054883	Q96DB9	FXYD5_HUMAN	FXYD domain-containing ion transport regulator 5	145	Extracellular (Potential).				microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity				0	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CCTCCGGAAACGGGGGCTGTT	0.552		NA											33	205					0	0	0	0
ZNF461	92283	broad.mit.edu	37	19	37129598	37129598	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:37129598A>T	uc002oem.2	-	6	1877	c.1649T>A	c.(1648-1650)GTC>GAC	p.V550D	ZNF461_uc002oen.2_Missense_Mutation_p.V519D|ZNF461_uc010xtj.1_Missense_Mutation_p.V527D	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGGAAACCTGACTGGCTTCTC	0.378		NA											4	13					0	0	0	0
LIPE	3991	broad.mit.edu	37	19	42930494	42930494	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:42930494C>T	uc002otr.2	-	1	1085	c.808G>A	c.(808-810)GTG>ATG	p.V270M	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	270					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				CCTGACATCACTTTATAACCA	0.488		NA											28	120					0	0	0	0
TRAPPC6A	79090	broad.mit.edu	37	19	45681404	45681404	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:45681404G>T	uc002paw.2	-	1	92	c.73C>A	c.(73-75)CCC>ACC	p.P25T	TRAPPC6A_uc002pav.2_Missense_Mutation_p.P25T|BLOC1S3_uc002pax.3_5'Flank			O75865	TPC6A_HUMAN	SubName: Full=TRAPPC6Adelta29-42; SubName: Full=Trafficking protein particle complex 6A, isoform CRA_a;	25					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding				0		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00872)|GBM - Glioblastoma multiforme(486;0.233)		CCCGGGCCGGGGTCGGGGTCG	0.612		NA											7	22					0.00448238	0.00461075	1	0
SNRPD2	6633	broad.mit.edu	37	19	46191786	46191786	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:46191786T>G	uc002pcw.2	-	2	338	c.41A>C	c.(40-42)GAG>GCG	p.E14A	SNRPD2_uc002pcv.2_Missense_Mutation_p.E4A	NM_004597	NP_004588	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 isoform 1	14					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		CTGCAGCTCCTCTGGGGTCAT	0.532		NA											16	134					0	0	0	0
SCAF1	58506	broad.mit.edu	37	19	50157990	50157990	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:50157990C>T	uc002poq.2	+	9	3605	c.3481C>T	c.(3481-3483)CCC>TCC	p.P1161S		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1161					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCCCCCTGGCCCCTCCAGCTA	0.672		NA											7	99					0	0	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51919567	51919567	+	Missense_Mutation	SNP	G	G	A	rs147122969	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:51919567G>A	uc002pwo.2	-	4	1367	c.751C>T	c.(751-753)CCA>TCA	p.P251S	SIGLEC10_uc002pwp.2_Missense_Mutation_p.P193S|SIGLEC10_uc002pwq.2_Missense_Mutation_p.P193S|SIGLEC10_uc002pwr.2_Missense_Mutation_p.P251S|SIGLEC10_uc010ycy.1_Missense_Mutation_p.P251S|SIGLEC10_uc010ycz.1_Missense_Mutation_p.P203S|SIGLEC10_uc010eow.2_Silent_p.R15R|SIGLEC10_uc002pws.1_Missense_Mutation_p.P177S	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	251	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TCAGTACCTGGCGTGTTGTCA	0.483		NA											6	136					0	0	0	0
LILRA4	23547	broad.mit.edu	37	19	54848719	54848719	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:54848719A>G	uc002qfj.2	-	5	961	c.904T>C	c.(904-906)TCC>CCC	p.S302P	LILRA4_uc002qfi.2_Missense_Mutation_p.S236P	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	302	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CACTCGGAGGAGACGTTGTGT	0.682		NA											8	31					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15415841	15415841	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:15415841G>A	uc002rcc.1	-	44	5517	c.5491C>T	c.(5491-5493)CCC>TCC	p.P1831S	NBAS_uc010exl.1_Missense_Mutation_p.P903S|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1831										ovary(2)|liver(1)|skin(1)	4						GGGATTTTGGGAACAAGTTTG	0.403		NA											9	58					0	0	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17697544	17697544	+	Silent	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:17697544A>G	uc002rcl.1	-	1	2163	c.2139T>C	c.(2137-2139)TGT>TGC	p.C713C	RAD51AP2_uc010exn.1_Silent_p.C704C	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	713										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTGTTGAGGACAACTCATAT	0.323		NA											6	66					0	0	0	0
LYG2	254773	broad.mit.edu	37	2	99863255	99863255	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:99863255A>C	uc002szw.1	-	3	185	c.72T>G	c.(70-72)AGT>AGG	p.S24R	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_Missense_Mutation_p.S24R|LYG2_uc002szx.1_Missense_Mutation_p.S24R	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	lysozyme G-like 2 precursor	24					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1						TCATTGAGTGACTGAAGGGGT	0.502		NA											21	74					0	0	0	0
EIF5B	9669	broad.mit.edu	37	2	100011184	100011184	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:100011184A>G	uc002tab.2	+	21	3276	c.3092A>G	c.(3091-3093)TAT>TGT	p.Y1031C	EIF5B_uc010yvq.1_Missense_Mutation_p.Y13C	NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	1031					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						CCTTTTAGGTATGCAGTAATT	0.338		NA											24	102					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098945	178098945	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368		NA	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			20	41					0	0	0	0
RTEL1	51750	broad.mit.edu	37	20	62326202	62326202	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr20:62326202C>T	uc002yfu.1	+	32	3561	c.3218C>T	c.(3217-3219)TCC>TTC	p.S1073F	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.S1073F|RTEL1_uc011abd.1_Missense_Mutation_p.S1097F|RTEL1_uc011abe.1_Missense_Mutation_p.S850F|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.S318F|TNFRSF6B_uc002yfy.2_5'Flank|TNFRSF6B_uc002yfz.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	1073					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCCCTGGGGTCCGCGGGCTGT	0.662		NA											5	52					0	0	0	0
BRWD1	54014	broad.mit.edu	37	21	40650700	40650700	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr21:40650700G>A	uc002yxk.1	-	10	1111	c.972C>T	c.(970-972)GGC>GGT	p.G324G	BRWD1_uc002yxl.2_Silent_p.G324G|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_5'UTR|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Silent_p.G44G	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	324	WD 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GCATTTGAACGCCTGGCCTAG	0.333		NA											33	79					0	0	0	0
HHATL	57467	broad.mit.edu	37	3	42739102	42739102	+	Missense_Mutation	SNP	C	C	T	rs140686107		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:42739102C>T	uc003clw.2	-	8	910	c.763G>A	c.(763-765)GTG>ATG	p.V255M	HHATL_uc003clx.2_Missense_Mutation_p.V255M	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	255	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		ATGGCCACCACGCTTAGGCCT	0.612		NA											9	69					0	0	0	0
ZIC4	84107	broad.mit.edu	37	3	147114119	147114119	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:147114119C>G	uc003ewd.1	-	3	481	c.208G>C	c.(208-210)GAC>CAC	p.D70H	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.D120H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	70						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GCGTACATGTCTCCAGGGAGC	0.726		NA											7	11					0	0	0	0
KLHL24	54800	broad.mit.edu	37	3	183381264	183381264	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:183381264G>A	uc003flv.2	+	4	1234	c.939G>A	c.(937-939)GAG>GAA	p.E313E	KLHL24_uc003flw.2_Silent_p.E313E|KLHL24_uc003flx.2_Silent_p.E313E	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	313						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GCTATTCTGAGGTGATAGTTG	0.333		NA											32	83					0	0	0	0
TNK2	10188	broad.mit.edu	37	3	195595233	195595233	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:195595233G>C	uc003fvu.1	-	12	2434	c.1891C>G	c.(1891-1893)CCC>GCC	p.P631A	TNK2_uc003fvq.1_Missense_Mutation_p.P38A|TNK2_uc003fvr.1_Missense_Mutation_p.P156A|TNK2_uc003fvs.1_Missense_Mutation_p.P663A|TNK2_uc003fvt.1_Missense_Mutation_p.P709A|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	631	Required for interaction with SRC.|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GCGGGCGGGGGGGGCAGCGGG	0.726		NA											7	33					0	0	0	0
SH3TC1	54436	broad.mit.edu	37	4	8224685	8224685	+	Missense_Mutation	SNP	G	G	T	rs148540586		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:8224685G>T	uc003gkv.3	+	10	1332	c.1231G>T	c.(1231-1233)GTG>TTG	p.V411L	SH3TC1_uc003gkw.3_Missense_Mutation_p.V335L|SH3TC1_uc003gkx.3_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	411							binding			large_intestine(2)|pancreas(1)	3						TGTCTGCAGCGTGTACAGCCT	0.602		NA											6	21					0.00198382	0.0020603	1	0
NPFFR2	10886	broad.mit.edu	37	4	73012967	73012967	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:73012967T>A	uc003hgg.2	+	4	1105	c.1007T>A	c.(1006-1008)CTC>CAC	p.L336H	NPFFR2_uc010iig.1_Missense_Mutation_p.L118H|NPFFR2_uc003hgi.2_Missense_Mutation_p.L237H|NPFFR2_uc003hgh.2_Missense_Mutation_p.L234H|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	336	Helical; Name=5; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			CCCCTCTCCCTCATTGTCATC	0.527		NA											16	36					0	0	0	0
HPSE	10855	broad.mit.edu	37	4	84216583	84216583	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:84216583G>C	uc003hoj.3	-	12	1645	c.1546C>G	c.(1546-1548)CTC>GTC	p.L516V	uc003hoi.2_5'Flank|HPSE_uc010ika.2_Missense_Mutation_p.L458V|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.L259V|HPSE_uc011cct.1_Missense_Mutation_p.L442V|HPSE_uc003hok.3_Missense_Mutation_p.L516V	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	516					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CCTGGCCGGAGAGGTTTTTCC	0.403		NA											11	69					0	0	0	0
FSTL5	56884	broad.mit.edu	37	4	162463813	162463813	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:162463813G>T	uc003iqh.2	-	9	1484	c.1048C>A	c.(1048-1050)CAG>AAG	p.Q350K	FSTL5_uc003iqi.2_Missense_Mutation_p.Q349K|FSTL5_uc010iqv.2_Missense_Mutation_p.Q349K	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	350	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCTCTAGCCTGACTCTCTGGA	0.418		NA											10	58					9.05e-12	1.02e-11	1	0
MYO10	4651	broad.mit.edu	37	5	16674967	16674967	+	Silent	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:16674967C>T	uc003jft.3	-	35	5427	c.4959G>A	c.(4957-4959)CTG>CTA	p.L1653L	MYO10_uc011cnb.1_Silent_p.L282L|MYO10_uc011cnc.1_Silent_p.L532L|MYO10_uc011cnd.1_Silent_p.L1010L|MYO10_uc011cne.1_Silent_p.L1010L|MYO10_uc010itx.2_Silent_p.L1275L	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1653	MyTH4.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TTTACCTTTTCAGATGGAACT	0.547		NA											15	135					0	0	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255327	140255327	+	Silent	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:140255327C>A	uc003lic.2	+	1	397	c.270C>A	c.(268-270)ATC>ATA	p.I90I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.I90I	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	90	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGACCGCGAGA	0.597		NA											29	226					4.75e-14	5.37e-14	1	0
FAT2	2196	broad.mit.edu	37	5	150922100	150922100	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:150922100A>G	uc003lue.3	-	9	8601	c.8588T>C	c.(8587-8589)CTT>CCT	p.L2863P	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2863	Extracellular (Potential).|Cadherin 25.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCACAGTCAAGTTCCTGGAG	0.532		NA											10	79					0	0	0	0
LARP1	23367	broad.mit.edu	37	5	154183811	154183811	+	Silent	SNP	C	C	T	rs140378046	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:154183811C>T	uc003lvp.2	+	14	2919	c.2490C>T	c.(2488-2490)AGC>AGT	p.S830S	LARP1_uc003lvo.2_Silent_p.S753S	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	830							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCTTGGAGAGCCATGTGGGCT	0.537		NA											6	128					0	0	0	0
CNOT8	9337	broad.mit.edu	37	5	154250226	154250226	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:154250226A>G	uc003lvu.2	+	5	796	c.317A>G	c.(316-318)GAC>GGC	p.D106G	CNOT8_uc011ddf.1_5'UTR|CNOT8_uc011ddg.1_5'UTR|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.D106G|CNOT8_uc010jig.2_5'UTR|CNOT8_uc010jif.2_5'UTR|CNOT8_uc003lvw.2_Missense_Mutation_p.D106G|CNOT8_uc011ddi.1_5'UTR|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	106					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTAGAGAGGACATGTACTCC	0.393		NA						Direct_reversal_of_damage					22	80					0	0	0	0
ACOT13	55856	broad.mit.edu	37	6	24667534	24667534	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:24667534A>G	uc003nek.2	+	1	272	c.43A>G	c.(43-45)ATG>GTG	p.M15V	TDP2_uc003nei.2_5'Flank|TDP2_uc003nej.2_5'Flank|TDP2_uc010jpu.1_5'Flank|ACOT13_uc010jpv.2_5'UTR	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	15					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						GATAAAGGCCATGACCAAGGC	0.512		NA									OREG0017230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	23					0	0	0	0
RUNX2	860	broad.mit.edu	37	6	45459775	45459775	+	Silent	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:45459775C>A	uc011dvx.1	+	6	993	c.783C>A	c.(781-783)GTC>GTA	p.V261V	RUNX2_uc011dvy.1_Silent_p.V261V|RUNX2_uc003oxt.2_Silent_p.V247V	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	261	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GAGTAGGTGTCCCGCCTCAGA	0.502		NA											14	128					1.05e-09	1.17e-09	1	0
KHDRBS2	202559	broad.mit.edu	37	6	62390900	62390900	+	Missense_Mutation	SNP	C	C	G	rs139583671		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:62390900C>G	uc003peg.2	-	9	1265	c.1018G>C	c.(1018-1020)GGA>CGA	p.G340R		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCCCTGTATCCCCCTCTGGCT	0.493		NA											13	45					0	0	0	0
GPRC6A	222545	broad.mit.edu	37	6	117128089	117128089	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:117128089C>T	uc003pxj.1	-	3	801	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	GPRC6A_uc003pxk.1_Missense_Mutation_p.R260Q|GPRC6A_uc003pxl.1_Missense_Mutation_p.R260Q	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	260	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTTCAGTGTCCGATTGATTCT	0.363		NA											11	77					0	0	0	0
SMPDL3A	10924	broad.mit.edu	37	6	123130244	123130244	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:123130244G>T	uc003pzg.2	+	8	1574	c.1053G>T	c.(1051-1053)TTG>TTT	p.L351F	SMPDL3A_uc003pzh.2_Missense_Mutation_p.L220F	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	351					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		AGGATATGTTGCAGTATTACT	0.413		NA											15	81					8.6e-14	9.71e-14	1	0
ECT2L	345930	broad.mit.edu	37	6	139206872	139206872	+	Missense_Mutation	SNP	G	G	A	rs79865247	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:139206872G>A	uc003qif.1	+	16	2267	c.2164G>A	c.(2164-2166)GCT>ACT	p.A722T	ECT2L_uc011edq.1_Intron	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	722	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TCTTCTCTACGCTGTCAGGCT	0.468		NA											17	40					0	0	0	0
MYCT1	80177	broad.mit.edu	37	6	153043080	153043080	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:153043080C>T	uc003qpd.3	+	2	408	c.400C>T	c.(400-402)CGA>TGA	p.R134*	MYCT1_uc010kjc.1_Intron|MYCT1_uc003qpc.3_Nonsense_Mutation_p.R134*	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	134						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CTGTGAACGTCGAAGCAACCT	0.498		NA											26	100					0	0	0	0
MAS1	4142	broad.mit.edu	37	6	160328742	160328742	+	Missense_Mutation	SNP	A	A	G	rs147267209	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:160328742A>G	uc003qsz.2	+	1	769	c.755A>G	c.(754-756)TAT>TGT	p.Y252C		NM_002377	NP_002368	P04201	MAS_HUMAN	MAS1 oncogene	252	Extracellular (Potential).				anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			ovary(2)|lung(2)	4		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		CTGCTGTACTATGAGTATTGG	0.458		NA											5	87					0	0	0	0
DDC	1644	broad.mit.edu	37	7	50611624	50611624	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:50611624C>A	uc003tpf.3	-	2	246	c.160G>T	c.(160-162)GAG>TAG	p.E54*	DDC_uc010kza.2_Nonsense_Mutation_p.E54*|DDC_uc003tpg.3_Nonsense_Mutation_p.E54*	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	54					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATGATGTCCTCAAACGTGTCT	0.562		NA											43	94					8.01e-26	9.11e-26	1	0
STEAP2	261729	broad.mit.edu	37	7	89861767	89861767	+	Silent	SNP	T	T	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:89861767T>G	uc003ujz.2	+	5	1695	c.1302T>G	c.(1300-1302)CTT>CTG	p.L434L	STEAP2_uc010len.2_Silent_p.L434L|STEAP2_uc003uka.2_Silent_p.L434L|STEAP2_uc003ukb.2_Silent_p.L434L|STEAP2_uc003ukc.2_Intron|STEAP2_uc003ukd.2_Silent_p.L434L	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	434	Helical; (Potential).				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					ACTTTGTTCTTGCTCTTGTTT	0.353		NA											14	31					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100479790	100479790	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:100479790A>G	uc003uwy.2	+	6	783	c.515A>G	c.(514-516)TAT>TGT	p.Y172C	SRRT_uc010lhl.1_Missense_Mutation_p.Y172C|SRRT_uc003uxa.2_Missense_Mutation_p.Y172C|SRRT_uc003uwz.2_Missense_Mutation_p.Y172C	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	172					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GTCAAGCGCTATAATGACTAC	0.557		NA											12	67					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151875040	151875040	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:151875040C>T	uc003wla.2	-	38	7717	c.7498G>A	c.(7498-7500)GTG>ATG	p.V2500M	MLL3_uc003wkz.2_Missense_Mutation_p.V1561M|MLL3_uc003wky.2_Missense_Mutation_p.V9M	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2500	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGAGGAGGCACAAGGAAGCGC	0.363		NA	N		medulloblastoma								12	106					0	0	0	0
HTR5A	3361	broad.mit.edu	37	7	154863042	154863042	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:154863042C>T	uc003wlu.1	+	1	497	c.433C>T	c.(433-435)CGC>TGC	p.R145C	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	145	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GTCCATCACGCGCCACATGGA	0.632		NA											7	30					0	0	0	0
ST18	9705	broad.mit.edu	37	8	53062328	53062328	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:53062328A>T	uc003xqz.2	-	11	2172	c.2016T>A	c.(2014-2016)TAT>TAA	p.Y672*	ST18_uc011ldq.1_Nonsense_Mutation_p.Y319*|ST18_uc011ldr.1_Nonsense_Mutation_p.Y637*|ST18_uc011lds.1_Nonsense_Mutation_p.Y577*|ST18_uc003xra.2_Nonsense_Mutation_p.Y672*|ST18_uc003xrb.2_Nonsense_Mutation_p.Y672*	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	672						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GAGTTTTGCTATAGTTGATAG	0.443		NA											9	52					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764890	77764890	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:77764890G>A	uc003yav.2	+	10	5985	c.5598G>A	c.(5596-5598)GCG>GCA	p.A1866A	ZFHX4_uc003yau.1_Silent_p.A1911A|ZFHX4_uc003yaw.1_Silent_p.A1866A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1866						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTGCCAAAGCGTTATTGGAAA	0.453		NA								HNSCC(33;0.089)			4	26					0	0	0	0
SLC26A7	115111	broad.mit.edu	37	8	92365191	92365191	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:92365191A>T	uc003yex.2	+	12	1559	c.1281A>T	c.(1279-1281)TTA>TTT	p.L427F	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.L427F|SLC26A7_uc003yfa.2_Missense_Mutation_p.L427F	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	427	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TCCGAGATTTAAAAAAATATT	0.328		NA											11	106					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100287445	100287445	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:100287445C>G	uc003yiv.2	+	19	2898	c.2787C>G	c.(2785-2787)ATC>ATG	p.I929M	VPS13B_uc003yiw.2_Missense_Mutation_p.I929M|VPS13B_uc003yiu.1_Missense_Mutation_p.I929M|VPS13B_uc003yix.1_Missense_Mutation_p.I400M	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	929					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTTCACAATCCAAGTTCCAC	0.398		NA											13	186					0	0	0	0
SLC25A32	81034	broad.mit.edu	37	8	104419953	104419953	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:104419953T>C	uc003yll.2	-	2	517	c.214A>G	c.(214-216)ATT>GTT	p.I72V	SLC25A32_uc011lhr.1_5'UTR	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	72	Solcar 1.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	AGTTTCCAAATGGTAGTCAAG	0.408		NA											18	167					0	0	0	0
LRP12	29967	broad.mit.edu	37	8	105509897	105509897	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:105509897G>T	uc003yma.2	-	5	978	c.883C>A	c.(883-885)CGT>AGT	p.R295S	LRP12_uc003ymb.2_Missense_Mutation_p.R276S|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	295	Extracellular (Potential).|CUB 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATGACTTTACGGTGATCACCA	0.358		NA											8	69					0.000157383	0.000167487	1	0
ADCY8	114	broad.mit.edu	37	8	131922053	131922053	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:131922053G>A	uc003ytd.3	-	6	1797	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L	ADCY8_uc010mds.2_Missense_Mutation_p.S514L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	514	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCACAGCACCGAGCCGGAGTG	0.478		NA								HNSCC(32;0.087)			12	142					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	145001198	145001198	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:145001198A>T	uc003zaf.1	-	29	4473	c.4303T>A	c.(4303-4305)TCC>ACC	p.S1435T	PLEC_uc003zab.1_Missense_Mutation_p.S1298T|PLEC_uc003zac.1_Missense_Mutation_p.S1302T|PLEC_uc003zad.2_Missense_Mutation_p.S1298T|PLEC_uc003zae.1_Missense_Mutation_p.S1266T|PLEC_uc003zag.1_Missense_Mutation_p.S1276T|PLEC_uc003zah.2_Missense_Mutation_p.S1284T|PLEC_uc003zaj.2_Missense_Mutation_p.S1325T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1435	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TTGGCCGGGGAGGCCACCGGC	0.642		NA											9	39					0	0	0	0
GLDC	2731	broad.mit.edu	37	9	6587232	6587232	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr9:6587232G>A	uc003zkc.2	-	15	1952	c.1759C>T	c.(1759-1761)CAA>TAA	p.Q587*		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	587					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCTTGAGCTTGATCCAGAGGC	0.393		NA											32	54					0	0	0	0
ECM2	1842	broad.mit.edu	37	9	95280053	95280053	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr9:95280053A>T	uc004ash.2	-	3	462	c.397T>A	c.(397-399)TGT>AGT	p.C133S	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.C133S|ECM2_uc011lty.1_Missense_Mutation_p.C133S|ECM2_uc004asg.2_Missense_Mutation_p.C133S|ECM2_uc011ltz.1_Missense_Mutation_p.C133S|ECM2_uc004asi.2_Missense_Mutation_p.C133S	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	133	VWFC.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						GTTTCATCACAAAGAACTCTT	0.522		NA											58	69					0	0	0	0
BSPRY	54836	broad.mit.edu	37	9	116130642	116130642	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr9:116130642G>A	uc004bhg.3	+	5	709	c.661G>A	c.(661-663)GCG>ACG	p.A221T	BSPRY_uc010muw.2_Intron	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	221	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						CTGGGCAACGGCGGTTCTTGG	0.527		NA											8	90					0	0	0	0
POF1B	79983	broad.mit.edu	37	X	84585990	84585990	+	Silent	SNP	G	G	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:84585990G>A	uc004eer.2	-	7	965	c.819C>T	c.(817-819)CAC>CAT	p.H273H	POF1B_uc004ees.2_Silent_p.H273H	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	273							actin binding				0						CTAATAAGCAGTGATATAGAT	0.378		NA											21	44					0	0	0	0
TNMD	64102	broad.mit.edu	37	X	99852545	99852545	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:99852545G>C	uc004efy.3	+	5	694	c.468G>C	c.(466-468)TGG>TGC	p.W156C	TNMD_uc004efz.2_Missense_Mutation_p.W156C	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	156	Extracellular (Potential).|BRICHOS.					integral to membrane				central_nervous_system(1)	1						CAGTGATTTGGGTCCCAGCAG	0.373		NA											11	99					0	0	0	0
XKRX	402415	broad.mit.edu	37	X	100177997	100177997	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:100177997T>A	uc004egn.2	-	2	994	c.389A>T	c.(388-390)GAG>GTG	p.E130V	XKRX_uc011mre.1_Intron	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	130						integral to membrane|plasma membrane				breast(1)	1						ATAGGGCTCCTCCTGCTCCTC	0.507		NA											88	135					0	0	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382142	101382142	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:101382142A>T	uc004eip.2	+	3	559	c.340A>T	c.(340-342)AGT>TGT	p.S114C		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						agagccagagagtgagggaga	0.229		NA											33	36					0	0	0	0
COL4A5	1287	broad.mit.edu	37	X	107909817	107909817	+	Silent	SNP	T	T	C			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:107909817T>C	uc004enz.1	+	39	3748	c.3546T>C	c.(3544-3546)GGT>GGC	p.G1182G	COL4A5_uc011mso.1_Silent_p.G1182G	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1182	Triple-helical region.		G -> R (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GACAGAAGGGTGAACCAGGTG	0.428		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				20	14					0	0	0	0
NOTCH2	4853	broad.mit.edu	37	1	120458389	120458389	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:120458389delG	uc001eik.2	-	34	7212	c.6956delC	c.(6955-6957)GCGfs	p.A2319fs		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	2319	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGAGCCCCCGCTGGTTGGGC	0.622		NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				15	62	---	---	---	---	NA	NA	NA	NA
GNPAT	8443	broad.mit.edu	37	1	231396328	231396330	+	In_Frame_Del	DEL	AAA	AAA	-			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:231396328_231396330delAAA	uc001hup.3	+	3	543_545	c.337_339delAAA	c.(337-339)AAAdel	p.K113del	GNPAT_uc009xfo.1_In_Frame_Del_p.K4del|GNPAT_uc009xfp.2_In_Frame_Del_p.K52del	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	113					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				AATGAGTCACAAACTGCGTCTTG	0.414		NA											37	314	---	---	---	---	NA	NA	NA	NA
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr18:34261459_34261460delAG	uc002kzt.1	+	12	1468_1469	c.1371_1372delAG	c.(1369-1374)GCAGAGfs	p.A457fs	FHOD3_uc002kzr.1_Frame_Shift_Del_p.A457fs|FHOD3_uc002kzs.1_Frame_Shift_Del_p.A457fs|FHOD3_uc010dmz.1_Frame_Shift_Del_p.A172fs	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	457_458	Potential.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.46		NA											7	83	---	---	---	---	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179395925	179395925	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:179395925delG	uc010zfg.1	-	307	97937	c.97713delC	c.(97711-97713)ACCfs	p.T32571fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.T26266fs|TTN_uc010zfi.1_Frame_Shift_Del_p.T26199fs|TTN_uc010zfj.1_Frame_Shift_Del_p.T26074fs|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33498							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCGTAGACGGTCATGGACC	0.483		NA											45	164	---	---	---	---	NA	NA	NA	NA
MATN4	8785	broad.mit.edu	37	20	43926821	43926822	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr20:43926821_43926822delGC	uc002xnn.2	-	7	1601_1602	c.1414_1415delGC	c.(1414-1416)GCCfs	p.A472fs	MATN4_uc002xno.2_Frame_Shift_Del_p.A431fs|MATN4_uc002xnp.2_Frame_Shift_Del_p.A390fs|MATN4_uc010zwr.1_Frame_Shift_Del_p.A420fs|MATN4_uc002xnr.1_Frame_Shift_Del_p.A472fs	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	513	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TTCCTCCTTGGCGCGCGCTGCC	0.683		NA											16	52	---	---	---	---	NA	NA	NA	NA