Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SPATA21	374955	broad.mit.edu	37	1	16727317	16727317	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:16727317G>A	uc001ayn.2	-	11	1555	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Missense_Mutation_p.R335W	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	358							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TTCTGCAACCGCAGCCGGCCT	0.582		NA											6	264					0	0	0	0
SASS6	163786	broad.mit.edu	37	1	100572486	100572486	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:100572486G>A	uc001dsu.2	-	12	1531	c.1390C>T	c.(1390-1392)CTA>TTA	p.L464L	SASS6_uc009wdz.2_Silent_p.L297L	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	464	Potential.				centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		TTATTTTTTAGAAGTTGTTTG	0.214		NA											3	20					0	0	0	0
STXBP3	6814	broad.mit.edu	37	1	109340774	109340774	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:109340774A>C	uc001dvy.2	+	16	1439	c.1364A>C	c.(1363-1365)CAA>CCA	p.Q455P	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	455					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TAGTCTCAACAAGGCAAACCG	0.313		NA											29	113					0	0	0	0
SYT6	148281	broad.mit.edu	37	1	114680442	114680442	+	Missense_Mutation	SNP	C	C	T	rs139165674	byFrequency	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:114680442C>T	uc001eev.2	-	3	741	c.491G>A	c.(490-492)CGT>CAT	p.R164H		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	249	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCAGGATACGCACAATCAG	0.542		NA											32	89					0	0	0	0
PTGFRN	5738	broad.mit.edu	37	1	117492010	117492010	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:117492010G>A	uc001egv.1	+	4	1166	c.1029G>A	c.(1027-1029)TCG>TCA	p.S343S		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	343	Ig-like C2-type 3.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TGCACAGCTCGCCTCATGTTG	0.572		NA											11	89					0	0	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858559	149858559	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:149858559G>C	uc001etd.2	+	1	35	c.35G>C	c.(34-36)CGC>CCC	p.R12P	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	12					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCAAGGCCCGCGCCAAGGCC	0.582		NA											12	128					0	0	0	0
THEM5	284486	broad.mit.edu	37	1	151824773	151824773	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:151824773G>A	uc009wnd.2	-	2	418	c.286C>T	c.(286-288)CGG>TGG	p.R96W		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	96							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTGAGTCCCCGGATGTGGTCT	0.542		NA											19	139					0	0	0	0
NTRK1	4914	broad.mit.edu	37	1	156843527	156843527	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:156843527A>G	uc001fqh.1	+	8	1009	c.953A>G	c.(952-954)AAT>AGT	p.N318S	NTRK1_uc001fqf.1_Missense_Mutation_p.N288S|NTRK1_uc009wsi.1_Missense_Mutation_p.N23S|NTRK1_uc001fqi.1_Missense_Mutation_p.N318S|NTRK1_uc009wsk.1_Missense_Mutation_p.N318S	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	318	Ig-like C2-type 2.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGCTCTTCAATGGCTCCGTG	0.637		NA	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			5	27					0	0	0	0
RNASEL	6041	broad.mit.edu	37	1	182554927	182554927	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:182554927G>A	uc001gpj.1	-	1	1182	c.1015C>T	c.(1015-1017)CAG>TAG	p.Q339*	RNASEL_uc009wxz.1_Nonsense_Mutation_p.Q339*|RNASEL_uc001gpk.2_Nonsense_Mutation_p.Q339*|RNASEL_uc009wya.1_Nonsense_Mutation_p.Q339*	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	339					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TGTGAGCTCTGAGGCTTCCAG	0.463		NA							Hereditary_Prostate_Cancer				11	84					0	0	0	0
DHX9	1660	broad.mit.edu	37	1	182812531	182812531	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:182812531A>G	uc001gpr.2	+	3	377	c.214A>G	c.(214-216)ATA>GTA	p.I72V	DHX9_uc001gps.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	72	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TTTGGTTCGAATAAATGAAAT	0.378		NA											7	74					0	0	0	0
HMCN1	83872	broad.mit.edu	37	1	186136045	186136045	+	Missense_Mutation	SNP	G	G	A	rs148826584	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:186136045G>A	uc001grq.1	+	100	15774	c.15545G>A	c.(15544-15546)CGA>CAA	p.R5182Q	HMCN1_uc001grs.1_Missense_Mutation_p.R751Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5182	EGF-like 2; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTGGCTTTCGAAGAACCTCT	0.458		NA											10	68					0	0	0	0
BTG2	7832	broad.mit.edu	37	1	203276431	203276431	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:203276431G>A	uc001gzq.2	+	2	413	c.342G>A	c.(340-342)GGG>GGA	p.G114G	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	114					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			ACCGCATTGGGGAGGACGGCT	0.667		NA											15	81					0	0	0	0
CD34	947	broad.mit.edu	37	1	208061164	208061164	+	Silent	SNP	A	A	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:208061164A>T	uc001hgw.1	-	8	1335	c.1077T>A	c.(1075-1077)GCT>GCA	p.A359A	CD34_uc001hgv.1_Silent_p.A201A|CD34_uc001hgx.1_3'UTR|CD34_uc010psj.1_Silent_p.A224A	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	359	Cytoplasmic (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						CGTTTTCCTGAGCCCCTCGGT	0.592		NA											5	53					0	0	0	0
TTC13	79573	broad.mit.edu	37	1	231060684	231060684	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:231060684C>T	uc001huf.3	-	14	1655	c.1624G>A	c.(1624-1626)GTG>ATG	p.V542M	TTC13_uc009xfi.2_Missense_Mutation_p.V489M|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.V489M|TTC13_uc009xfk.1_Missense_Mutation_p.V432M	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	542							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		GTACGCTGCACGGCTTGCATG	0.463		NA											24	101					0	0	0	0
OR2T2	401992	broad.mit.edu	37	1	248616314	248616314	+	Silent	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:248616314C>A	uc001iek.1	+	1	216	c.216C>A	c.(214-216)ACC>ACA	p.T72T		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCATGGATACCATCTACATCT	0.512		NA											16	189					3.52e-12	4.38e-12	1	0
OR2T2	401992	broad.mit.edu	37	1	248616457	248616457	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:248616457C>A	uc001iek.1	+	1	359	c.359C>A	c.(358-360)GCC>GAC	p.A120D		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTCTCATGGCCTATGACCGC	0.547		NA											12	130					5.01e-05	5.96e-05	1	0
PFKFB3	5209	broad.mit.edu	37	10	6255710	6255710	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:6255710A>G	uc001ije.2	+	2	585	c.201A>G	c.(199-201)AAA>AAG	p.K67K	PFKFB3_uc001ijd.2_Silent_p.K47K|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Silent_p.K81K|PFKFB3_uc001ijf.2_Silent_p.K67K	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	67	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						TCCCCACAAAAGGTGAGACTG	0.612		NA											3	158					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55600185	55600185	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:55600185C>A	uc001jju.1	-	29	4273	c.3878G>T	c.(3877-3879)CGG>CTG	p.R1293L	PCDH15_uc010qhq.1_Missense_Mutation_p.R1298L|PCDH15_uc010qhr.1_Missense_Mutation_p.R1293L|PCDH15_uc010qhs.1_Missense_Mutation_p.R1305L|PCDH15_uc010qht.1_Missense_Mutation_p.R1300L|PCDH15_uc010qhu.1_Missense_Mutation_p.R1293L|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1293L|PCDH15_uc010qhw.1_Missense_Mutation_p.R1256L|PCDH15_uc010qhx.1_Missense_Mutation_p.R1222L|PCDH15_uc010qhy.1_Missense_Mutation_p.R1298L|PCDH15_uc010qhz.1_Missense_Mutation_p.R1293L|PCDH15_uc010qia.1_Missense_Mutation_p.R1271L|PCDH15_uc010qib.1_Missense_Mutation_p.R1271L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1293	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATCTCCATGCCGGCGAGCTCC	0.448		NA								HNSCC(58;0.16)			11	71					0.00829132	0.00944551	1	0
ARID5B	84159	broad.mit.edu	37	10	63829502	63829502	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:63829502G>A	uc001jlt.1	+	8	1171	c.1145G>A	c.(1144-1146)GGC>GAC	p.G382D	ARID5B_uc001jlu.1_Missense_Mutation_p.G139D	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	382	ARID.				liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GATGAATTAGGCGGTAATCCT	0.403		NA											12	58					0	0	0	0
ZNF503	84858	broad.mit.edu	37	10	77160129	77160129	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:77160129C>G	uc001jxg.2	-	2	655	c.319G>C	c.(319-321)GAT>CAT	p.D107H	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					TTCTTGGCATCGAGCTGCGGG	0.597		NA											8	45					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1156593	1156593	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:1156593G>A	uc009ycr.1	+	7	736	c.610G>A	c.(610-612)GCC>ACC	p.A204T		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	200	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCAAATACGCCAACAAGAC	0.607		NA											13	101					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1265999	1265999	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:1265999T>C	uc009ycr.1	+	48	9929	c.9803T>C	c.(9802-9804)CTT>CCT	p.L3268P	MUC5B_uc001ltb.2_Missense_Mutation_p.L2633P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2630	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).|RTL -> LTP (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCACGCACGCTTCCAGTGTGG	0.637		NA											3	148					0	0	0	0
CARS	833	broad.mit.edu	37	11	3038413	3038413	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:3038413C>A	uc001lxh.2	-	15	1665	c.1591G>T	c.(1591-1593)GCC>TCC	p.A531S	CARS_uc001lxe.2_Missense_Mutation_p.A521S|CARS_uc001lxf.2_Missense_Mutation_p.A614S|CARS_uc001lxg.2_Missense_Mutation_p.A531S|CARS_uc010qxo.1_Missense_Mutation_p.A614S|CARS_uc010qxp.1_Missense_Mutation_p.A544S	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	531					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	GCTTTCCGGGCTGCCATATAG	0.577		NA	T	ALK	ALCL								8	71					5.18e-06	6.2e-06	1	0
NUP98	4928	broad.mit.edu	37	11	3697423	3697423	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:3697423G>A	uc001lyh.2	-	33	5660	c.5369C>T	c.(5368-5370)TCC>TTC	p.S1790F	NUP98_uc001lyi.2_Missense_Mutation_p.S1716F|NUP98_uc001lyg.2_Missense_Mutation_p.S755F	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1807					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCGCAGATAGGACTGGGTAAG	0.587		NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								11	60					0	0	0	0
TPH1	7166	broad.mit.edu	37	11	18054883	18054883	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:18054883C>G	uc001mnp.2	-	3	366	c.340G>C	c.(340-342)GAC>CAC	p.D114H	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	114					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TGGTCCAGGTCAGAAATCTTC	0.284		NA											21	157					0	0	0	0
HRASLS2	54979	broad.mit.edu	37	11	63326093	63326093	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:63326093G>A	uc001nxg.1	-	3	217	c.158C>T	c.(157-159)GCC>GTC	p.A53V		NM_017878	NP_060348	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	53					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity				0						GTTGGTCAGGGCAGACAGGAC	0.557		NA											4	162					0	0	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68701351	68701351	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:68701351G>A	uc001ook.1	+	10	1609	c.1507G>A	c.(1507-1509)GAG>AAG	p.E503K	IGHMBP2_uc001ool.1_Missense_Mutation_p.E127K|IGHMBP2_uc001oom.1_Missense_Mutation_p.E81K	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	503					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGAGCTGGAGGAGGAGGACGA	0.562		NA											7	16					0	0	0	0
MYO7A	4647	broad.mit.edu	37	11	76919561	76919561	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:76919561C>T	uc001oyb.2	+	43	6215	c.5943C>T	c.(5941-5943)GAC>GAT	p.D1981D	MYO7A_uc001oyc.2_Silent_p.D1943D|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1981	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCATCAAGGACGGTAATGAGG	0.597		NA											3	21					0	0	0	0
SCN3B	55800	broad.mit.edu	37	11	123516409	123516410	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:123516409_123516410GG>AA	uc001pza.1	-	3	511_512	c.104_105CC>TT	c.(103-105)GCC>GTT	p.A35V	SCN3B_uc001pzb.1_Missense_Mutation_p.A35V	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	35	Ig-like C2-type.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TGCCCTGCACGGCCTCCGTCTC	0.629		NA											15	100					0	0	0	0
GOLT1B	51026	broad.mit.edu	37	12	21668638	21668638	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:21668638A>G	uc001rez.2	+	5	573	c.414A>G	c.(412-414)GTA>GTG	p.V138V	GOLT1B_uc009zis.2_RNA|GOLT1B_uc009zit.2_RNA|GOLT1B_uc009ziu.2_RNA	NM_016072	NP_057156	Q9Y3E0	GOT1B_HUMAN	golgi transport 1 homolog B	138	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport|vesicle-mediated transport	endoplasmic reticulum|Golgi membrane|integral to membrane	signal transducer activity				0						ACAATATGGTATAACAACAAG	0.264		NA											8	58					0	0	0	0
ASB8	140461	broad.mit.edu	37	12	48543152	48543152	+	Silent	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:48543152T>C	uc001rrh.2	-	4	1033	c.864A>G	c.(862-864)GAA>GAG	p.E288E	ASB8_uc010slr.1_Silent_p.E284E	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	288	SOCS box.				intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						TCTCCGGCTATTCTAAAAGTA	0.517		NA											6	50					0	0	0	0
TUBA1B	10376	broad.mit.edu	37	12	49521800	49521800	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:49521800C>A	uc001rtm.2	-	4	1518	c.1297G>T	c.(1297-1299)GAG>TAG	p.E433*	TUBA1B_uc001rto.2_Nonsense_Mutation_p.E398*|TUBA1B_uc001rtk.2_Nonsense_Mutation_p.E398*|TUBA1B_uc001rtl.2_Nonsense_Mutation_p.E398*|TUBA1B_uc001rtn.2_Nonsense_Mutation_p.E280*|uc010smg.1_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	433					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						CCAACCTCCTCATAATCCTTC	0.517		NA											29	168					1.89e-17	2.37e-17	1	0
ESYT1	23344	broad.mit.edu	37	12	56524381	56524381	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:56524381G>A	uc001sjq.2	+	2	456	c.406G>A	c.(406-408)GTG>ATG	p.V136M	ESYT1_uc001sjr.2_Missense_Mutation_p.V136M	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	136						integral to membrane				ovary(4)|skin(1)	5						CTTCCCAGACGTGGAAAAGGC	0.507		NA											12	76					0	0	0	0
TMEM19	55266	broad.mit.edu	37	12	72091109	72091109	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:72091109A>G	uc001sws.2	+	4	1015	c.432A>G	c.(430-432)ACA>ACG	p.T144T	TMEM19_uc001swr.1_Silent_p.T130T|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	144						integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGTACCCACAGAACTGGCCC	0.468		NA											27	128					0	0	0	0
PWP1	11137	broad.mit.edu	37	12	108102726	108102726	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:108102726A>G	uc001tmo.1	+	12	1188	c.1101A>G	c.(1099-1101)GTA>GTG	p.V367V	PWP1_uc009zuu.1_Silent_p.V367V	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	367					transcription, DNA-dependent	nucleus					0						ACGGCTTTGTATATAATTTGG	0.368		NA											5	34					0	0	0	0
TMEM132B	114795	broad.mit.edu	37	12	126139185	126139185	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:126139185T>A	uc001uhe.1	+	9	3174	c.3166T>A	c.(3166-3168)TGC>AGC	p.C1056S	TMEM132B_uc001uhf.1_Missense_Mutation_p.C568S	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1056	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CAAGTGGGTCTGCCAAGATAT	0.473		NA											4	75					0	0	0	0
SPERT	220082	broad.mit.edu	37	13	46287817	46287817	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:46287817G>A	uc001van.1	+	3	737	c.657G>A	c.(655-657)CTG>CTA	p.L219L	SPERT_uc001vao.2_Silent_p.L183L	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	219						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CGCCACTGCTGCACAAAGACA	0.657		NA											4	47					0	0	0	0
LPAR6	10161	broad.mit.edu	37	13	48985944	48985944	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:48985944T>C	uc010acu.2	-	1	1710	c.616A>G	c.(616-618)ATG>GTG	p.M206V	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Missense_Mutation_p.M206V|LPAR6_uc001vcf.2_Missense_Mutation_p.M206V	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	206	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						TTTAGCACCATACTAGAACAA	0.254		NA											5	38					0	0	0	0
DIS3	22894	broad.mit.edu	37	13	73334727	73334727	+	Silent	SNP	G	G	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:73334727G>T	uc001vix.3	-	20	3107	c.2733C>A	c.(2731-2733)ATC>ATA	p.I911I	DIS3_uc001viy.3_Silent_p.I881I|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	911					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AGTCTAACATGATTTTCACTT	0.333		NA								Multiple Myeloma(4;0.011)			12	57					6.4e-05	7.57e-05	1	0
CARS2	79587	broad.mit.edu	37	13	111299462	111299462	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:111299462C>T	uc001vrd.2	-	11	1219	c.1179G>A	c.(1177-1179)GCG>GCA	p.A393A	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	393					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	CCCACAGCATCGCTTCCCTGA	0.672		NA											3	14					0	0	0	0
C13orf16	121793	broad.mit.edu	37	13	111973249	111973249	+	Silent	SNP	G	G	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:111973249G>T	uc001vsa.2	+	2	141	c.12G>T	c.(10-12)GTG>GTT	p.V4V		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	4	Extracellular (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TGGAATACGTGCTGGAAGTGA	0.642		NA											5	108					0.000602214	0.000702	1	0
OSGEP	55644	broad.mit.edu	37	14	20917164	20917164	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:20917164G>A	uc001vxf.2	-	5	872	c.516C>T	c.(514-516)AAC>AAT	p.N172N		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	172					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		GACTTGGGTCGTTAGAAATCT	0.453		NA											21	198					0	0	0	0
GMPR2	51292	broad.mit.edu	37	14	24702464	24702464	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:24702464C>T	uc001wnr.2	+	2	387	c.5C>T	c.(4-6)CCT>CTT	p.P2L	NEDD8_uc001wnn.2_5'Flank|NEDD8_uc001wno.2_5'Flank|NEDD8_uc001wnp.2_5'Flank|GMPR2_uc001wnq.1_Missense_Mutation_p.P2L|GMPR2_uc001wnv.2_5'UTR|GMPR2_uc001wns.2_Missense_Mutation_p.P2L|GMPR2_uc001wnt.2_Missense_Mutation_p.P2L|GMPR2_uc001wnu.2_5'UTR|GMPR2_uc001wnw.2_Missense_Mutation_p.P2L|GMPR2_uc010all.2_Missense_Mutation_p.P2L|GMPR2_uc001wnx.2_Missense_Mutation_p.P20L|GMPR2_uc010tod.1_Missense_Mutation_p.P2L|GMPR2_uc010alk.1_Missense_Mutation_p.P2L|GMPR2_uc010toe.1_Missense_Mutation_p.P2L	NM_001002001	NP_001002001	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2 isoform 2	2					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			ovary(3)	3				GBM - Glioblastoma multiforme(265;0.0181)		AGCGCCATGCCTCATATTGAC	0.517		NA											79	341					0	0	0	0
COCH	1690	broad.mit.edu	37	14	31348049	31348049	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:31348049G>A	uc001wqr.2	+	5	352	c.272G>A	c.(271-273)CGA>CAA	p.R91Q	COCH_uc001wqp.2_Missense_Mutation_p.R91Q|COCH_uc001wqq.3_Missense_Mutation_p.R91Q|uc001wqs.2_Intron|COCH_uc001wqt.1_5'Flank	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	91	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		GGACCTGTACGAGTCTATAGC	0.458		NA											17	81					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	79933641	79933641	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:79933641C>T	uc001xun.2	+	13	2712	c.2221C>T	c.(2221-2223)CGG>TGG	p.R741W	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.R109W|NRXN3_uc010asw.2_Missense_Mutation_p.R109W|NRXN3_uc001xur.3_Missense_Mutation_p.R109W	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1114	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCCCAGCACGCGGTCTGACCG	0.577		NA											19	94					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94089060	94089060	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:94089060C>T	uc001ybv.1	+	28	5099	c.5016C>T	c.(5014-5016)TCC>TCT	p.S1672S	KIAA1409_uc001ybs.1_Silent_p.S1650S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1827						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CTGAGGAATCCGAATTTAAGA	0.473		NA											7	46					0	0	0	0
SORD	6652	broad.mit.edu	37	15	45353314	45353314	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr15:45353314C>G	uc001zul.3	+	4	456	c.315C>G	c.(313-315)TTC>TTG	p.F105L	SORD_uc010uel.1_Intron|SORD_uc001zum.3_Missense_Mutation_p.F105L|SORD_uc010bdz.2_Missense_Mutation_p.F26L	NM_003104	NP_003095	Q00796	DHSO_HUMAN	sorbitol dehydrogenase	105					fructose biosynthetic process|glucose metabolic process|L-xylitol catabolic process|sorbitol catabolic process|sperm motility	cilium|extracellular space|flagellum|membrane fraction|mitochondrial membrane|soluble fraction	L-iditol 2-dehydrogenase activity|NAD binding|sugar binding|zinc ion binding				0		all_cancers(109;3.43e-12)|all_epithelial(112;2.33e-10)|Lung NSC(122;6.01e-07)|all_lung(180;4.38e-06)|Melanoma(134;0.0122)		all cancers(107;1.6e-18)|GBM - Glioblastoma multiforme(94;4.95e-07)|COAD - Colon adenocarcinoma(120;0.0704)|Colorectal(133;0.0706)	NADH(DB00157)	ATGATGAATTCTGCAAGATGG	0.542		NA											7	57					0	0	0	0
RNF111	54778	broad.mit.edu	37	15	59373425	59373425	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr15:59373425C>T	uc002afv.2	+	8	2518	c.2239C>T	c.(2239-2241)CCT>TCT	p.P747S	RNF111_uc002afs.2_Missense_Mutation_p.P747S|RNF111_uc002aft.2_Missense_Mutation_p.P747S|RNF111_uc002afu.2_Missense_Mutation_p.P746S|RNF111_uc002afw.2_Missense_Mutation_p.P747S|RNF111_uc002afx.2_Missense_Mutation_p.P273S	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	747	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		GAGACTGCATCCTCATGAAGT	0.463		NA											11	83					0	0	0	0
THSD4	79875	broad.mit.edu	37	15	72030124	72030124	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr15:72030124G>A	uc002atb.1	+	10	1763	c.1684G>A	c.(1684-1686)GAA>AAA	p.E562K	THSD4_uc010ukg.1_Missense_Mutation_p.E202K|THSD4_uc002ate.2_Missense_Mutation_p.E202K	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	562						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GGAGGAGGGAGAACAGAAAGG	0.562		NA											11	62					0	0	0	0
SNRNP25	79622	broad.mit.edu	37	16	104045	104045	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:104045A>G	uc002cfj.3	+	1	217	c.56A>G	c.(55-57)GAT>GGT	p.D19G	POLR3K_uc002cfi.1_5'Flank|SNRNP25_uc002cfk.3_5'Flank	NM_024571	NP_078847	Q9BV90	SNR25_HUMAN	U11/U12 snRNP 25K protein	19					mRNA processing	U12-type spliceosomal complex					0						CTGCTCTGCGATCTGCCGATC	0.701		NA											5	22					0	0	0	0
IGFALS	3483	broad.mit.edu	37	16	1842153	1842153	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:1842153A>G	uc002cmy.2	-	2	347	c.266T>C	c.(265-267)GTC>GCC	p.V89A	IGFALS_uc010uvn.1_Missense_Mutation_p.V127A|IGFALS_uc010uvo.1_5'UTR	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	89	LRR 1.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						TGCCGGGGGGACGGACGAGAG	0.687		NA											3	40					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	20994156	20994156	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:20994156C>T	uc010vbe.1	-	49	7746	c.7746G>A	c.(7744-7746)TCG>TCA	p.S2582S	DNAH3_uc010vbd.1_Silent_p.S17S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2582	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AATTGATCAGCGAAGGGAACA	0.483		NA											13	78					0	0	0	0
GDPD3	79153	broad.mit.edu	37	16	30124099	30124100	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:30124099_30124100GC>AA	uc002dwp.2	-	3	276_277	c.197_198GC>TT	c.(196-198)CGC>CTT	p.R66L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.R4L|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	66	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						GGAGGTCCGAGCGCTGGGCCAT	0.653		NA									OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	84					0	0	0	0
ITGAX	3687	broad.mit.edu	37	16	31383062	31383062	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:31383062T>C	uc002ebu.1	+	17	2184	c.2117T>C	c.(2116-2118)CTC>CCC	p.L706P	ITGAX_uc002ebt.2_Missense_Mutation_p.L706P	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	706	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTCCGAGTCCTCGGGCTGAAG	0.632		NA											7	85					0	0	0	0
ABCC11	85320	broad.mit.edu	37	16	48226462	48226462	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:48226462G>A	uc002eff.1	-	19	3025	c.2675C>T	c.(2674-2676)TCC>TTC	p.S892F	ABCC11_uc002efg.1_Missense_Mutation_p.S892F|ABCC11_uc002efh.1_Missense_Mutation_p.S892F|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	892	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CAGGGCCGTGGATGCCTTCCT	0.562		NA							Cerumen_Type				10	79					0	0	0	0
CDYL2	124359	broad.mit.edu	37	16	80638322	80638322	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:80638322A>G	uc002ffs.2	-	7	1589	c.1484T>C	c.(1483-1485)CTT>CCT	p.L495P		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	495						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						GTAGCTGAAAAGGGAGTCAAG	0.552		NA											3	129					0	0	0	0
ZNF276	92822	broad.mit.edu	37	16	89789017	89789017	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:89789017C>T	uc002fos.3	+	2	381	c.284C>T	c.(283-285)TCC>TTC	p.S95F	C16orf7_uc002fol.1_5'Flank|C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.S20F|ZNF276_uc002foq.3_Missense_Mutation_p.S20F|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	95	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CGCAGCATCTCCGAGAGGGCG	0.667		NA											10	94					0	0	0	0
CAMTA2	23125	broad.mit.edu	37	17	4873662	4873662	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:4873662T>C	uc002gah.1	-	17	3086	c.2978A>G	c.(2977-2979)GAC>GGC	p.D993G	SPAG7_uc002gae.2_5'Flank|SPAG7_uc002gaf.2_5'Flank|CAMTA2_uc010cku.1_Missense_Mutation_p.D1016G|CAMTA2_uc002gag.1_Missense_Mutation_p.D992G|CAMTA2_uc002gai.1_Missense_Mutation_p.D995G|CAMTA2_uc010ckv.1_Missense_Mutation_p.D640G	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	993					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGGGAAATGGTCCACATTCTC	0.602		NA											3	108					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	G	A	rs121913344		TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	75					0	0	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274379	39274379	+	Silent	SNP	G	G	A	rs411996	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:39274379G>A	uc002hvz.2	-	1	228	c.189C>T	c.(187-189)ACC>ACT	p.T63T		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	63	8.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGCGGCAGCAGGTGGGCTGGC	0.657		NA											9	94					0	0	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48597049	48597049	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:48597049G>A	uc010wmr.1	+	7	1108	c.946G>A	c.(946-948)GAG>AAG	p.E316K	MYCBPAP_uc002iqx.2_Missense_Mutation_p.E316K|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	279					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CTTGGGAGATGAGATGACAGG	0.547		NA											7	44					0	0	0	0
CA10	56934	broad.mit.edu	37	17	49825158	49825158	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:49825158G>A	uc002itw.3	-	4	1286	c.300C>T	c.(298-300)AAC>AAT	p.N100N	CA10_uc002itu.3_Silent_p.N29N|CA10_uc002itv.3_Silent_p.N106N|CA10_uc002itx.3_Silent_p.N100N|CA10_uc002ity.3_Silent_p.N100N|CA10_uc002itz.2_Silent_p.N100N	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	100					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTCTTCCAGTGTTGTACATGG	0.542		NA											11	81					0	0	0	0
INTS2	57508	broad.mit.edu	37	17	59972740	59972740	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:59972740A>G	uc002izn.2	-	12	1599	c.1523T>C	c.(1522-1524)GTA>GCA	p.V508A	INTS2_uc002izm.2_Missense_Mutation_p.V500A	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	508					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TGGCTTAATTACAATCTAAAA	0.294		NA											4	15					0	0	0	0
MRC2	9902	broad.mit.edu	37	17	60749025	60749025	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:60749025T>A	uc002jad.2	+	7	1535	c.1133T>A	c.(1132-1134)GTG>GAG	p.V378E	MRC2_uc002jac.2_Missense_Mutation_p.V378E	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	378	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGGGCCAATGTGAAGGTGGAG	0.632		NA											6	42					0	0	0	0
C19orf21	126353	broad.mit.edu	37	19	758519	758519	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:758519G>T	uc002lpo.2	+	2	1656	c.1573G>T	c.(1573-1575)GTC>TTC	p.V525F		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	525										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCCCCCATGTCTGGGGCTG	0.672		NA											17	58					1.03e-11	1.28e-11	1	0
DENND1C	79958	broad.mit.edu	37	19	6476960	6476960	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:6476960C>T	uc002mfe.2	-	10	678	c.586G>A	c.(586-588)GTG>ATG	p.V196M	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_Translation_Start_Site|DENND1C_uc010xje.1_Missense_Mutation_p.V152M	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	196	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						ACGGCCACCACCAGCTCCGTT	0.642		NA											12	40					0	0	0	0
ZNF177	7730	broad.mit.edu	37	19	9489013	9489013	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:9489013G>C	uc002mli.2	+	8	689	c.26G>C	c.(25-27)TGG>TCG	p.W9S	ZNF177_uc002mlj.2_5'UTR|ZNF177_uc002mlk.2_Missense_Mutation_p.W9S	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	9					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGACAACCTGGTCACAGGTA	0.507		NA											4	52					0	0	0	0
FARSA	2193	broad.mit.edu	37	19	13035607	13035607	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:13035607C>T	uc002mvs.2	-	10	1089	c.1041G>A	c.(1039-1041)CCG>CCA	p.P347P	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Silent_p.P316P|FARSA_uc010dyy.1_Silent_p.P268P	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	347					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	AGTACTTGACCGGAGTGAAGG	0.632		NA											12	161					0	0	0	0
ASF1B	55723	broad.mit.edu	37	19	14247232	14247232	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:14247232C>T	uc002mye.2	-	1	209	c.37G>A	c.(37-39)GAG>AAG	p.E13K	uc002myf.2_5'Flank	NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	13	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						CTCGGGTTCTCCAGGACCGCC	0.716		NA											13	49					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363559	22363559	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:22363559C>G	uc002nqs.1	-	3	1278	c.960G>C	c.(958-960)TGG>TGC	p.W320C		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	320	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGCTTGAGGACCAGCTGAAGG	0.433		NA											11	105					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22939799	22939799	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:22939799G>A	uc010xrh.1	-	6	2532	c.2532C>T	c.(2530-2532)GCC>GCT	p.A844A		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GTTTCCTAAGGGCTGAGAAAT	0.348		NA											13	86					0	0	0	0
WTIP	126374	broad.mit.edu	37	19	34984493	34984493	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:34984493G>T	uc002nvm.2	+	5	997	c.997G>T	c.(997-999)GAG>TAG	p.E333*		NM_001080436	NP_001073905			Wilms tumor 1 interacting protein												0	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGTGGACGTGGAGAACAACAT	0.617		NA											11	99					0.00829132	0.00944551	1	0
MLL4	9757	broad.mit.edu	37	19	36212436	36212436	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:36212436C>T	uc010eei.2	+	3	2187	c.2187C>T	c.(2185-2187)AAC>AAT	p.N729N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	729	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCTGAGCAACGGGCCACAGA	0.662		NA											6	60					0	0	0	0
HNRNPL	3191	broad.mit.edu	37	19	39336375	39336375	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:39336375C>A	uc010xul.1	-	4	636	c.625G>T	c.(625-627)GAT>TAT	p.D209Y	HNRNPL_uc010xum.1_Missense_Mutation_p.D76Y|HNRNPL_uc010xun.1_5'Flank	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	209	RRM 2.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TAAAGAACATCCTGCAAAAGC	0.478		NA											5	59					0.000602214	0.000702	1	0
STRN4	29888	broad.mit.edu	37	19	47226075	47226075	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:47226075C>T	uc002pfl.2	-	14	1931	c.1898G>A	c.(1897-1899)GGC>GAC	p.G633D	STRN4_uc002pfm.2_Missense_Mutation_p.G640D|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	633						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		ACCGCTGCTGCCCCGGGACTC	0.627		NA											23	134					0	0	0	0
DTNB	1838	broad.mit.edu	37	2	25754408	25754408	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:25754408G>C	uc002rgh.2	-	9	1185	c.935C>G	c.(934-936)ACG>AGG	p.T312R	DTNB_uc010yko.1_Missense_Mutation_p.T255R|DTNB_uc010ykp.1_Missense_Mutation_p.T108R|DTNB_uc002rgo.2_Missense_Mutation_p.T133R|DTNB_uc002rgi.2_Missense_Mutation_p.T312R|DTNB_uc002rgj.2_Missense_Mutation_p.T312R|DTNB_uc002rgk.2_Missense_Mutation_p.T312R|DTNB_uc002rgl.2_Missense_Mutation_p.T312R|DTNB_uc002rgq.2_Missense_Mutation_p.T312R|DTNB_uc002rgm.2_Missense_Mutation_p.T312R|DTNB_uc002rgn.2_Missense_Mutation_p.T108R|DTNB_uc002rgr.1_Missense_Mutation_p.T301R|DTNB_uc010ykq.1_Missense_Mutation_p.T165R	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	312						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGTTCTCTCGTGGGTACACA	0.438		NA											16	104					0	0	0	0
SOS1	6654	broad.mit.edu	37	2	39251221	39251221	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:39251221T>A	uc002rrk.3	-	9	1173	c.1132A>T	c.(1132-1134)ACA>TCA	p.T378S	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_5'UTR|SOS1_uc002rrl.2_Missense_Mutation_p.T110S	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	378	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AGCAAAGCTGTTATTGCTTGT	0.303		NA							Noonan_syndrome				4	49					0	0	0	0
SLC8A1	6546	broad.mit.edu	37	2	40397431	40397431	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:40397431G>A	uc002rrx.2	-	6	2052	c.2028C>T	c.(2026-2028)ATC>ATT	p.I676I	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Silent_p.I671I|SLC8A1_uc002rrz.2_Silent_p.I663I|SLC8A1_uc002rsa.2_Intron|SLC8A1_uc002rsd.3_Intron|SLC8A1_uc002rsb.1_Silent_p.I668I	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	676	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTGCAATGGTGATTACAGTAG	0.433		NA											8	56					0	0	0	0
RGPD4	285190	broad.mit.edu	37	2	108487680	108487680	+	Missense_Mutation	SNP	G	G	A	rs2919157		TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:108487680G>A	uc010ywk.1	+	20	3302	c.3220G>A	c.(3220-3222)GTA>ATA	p.V1074I	RGPD4_uc002tdu.2_Missense_Mutation_p.V261I|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1074	RanBD1 1.				intracellular transport		binding			skin(2)	2						TGATGCTGAGGTAAGGCAGTG	0.383		NA											71	513					0	0	0	0
SULT1C2	6819	broad.mit.edu	37	2	108924864	108924864	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:108924864G>A	uc002tdy.2	+	8	1288	c.835G>A	c.(835-837)GAA>AAA	p.E279K	SULT1C2_uc002tdx.2_Missense_Mutation_p.E290K|SULT1C2_uc010ywq.1_Missense_Mutation_p.E293K	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	279					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						GAGGTTTGATGAAATCTATAG	0.413		NA											9	86					0	0	0	0
ERCC3	2071	broad.mit.edu	37	2	128029027	128029027	+	Silent	SNP	T	T	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:128029027T>A	uc002toh.1	-	12	1925	c.1830A>T	c.(1828-1830)GTA>GTT	p.V610V	ERCC3_uc002toe.1_Silent_p.V365V|ERCC3_uc002tof.1_Silent_p.V546V|ERCC3_uc002tog.1_Silent_p.V546V	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	610	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		AAGTGTCACCTACCTACAGAA	0.413		NA	Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				8	118					0	0	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882145	228882145	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:228882145C>G	uc002vpq.2	-	7	3472	c.3425G>C	c.(3424-3426)AGA>ACA	p.R1142T	SPHKAP_uc002vpp.2_Missense_Mutation_p.R1142T|SPHKAP_uc010zlx.1_Missense_Mutation_p.R1142T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1142						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCAAATCCTCTCCCTTCATT	0.527		NA											9	46					0	0	0	0
GIGYF2	26058	broad.mit.edu	37	2	233675989	233675989	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:233675989A>C	uc002vti.3	+	19	2271	c.1934A>C	c.(1933-1935)AAA>ACA	p.K645T	GIGYF2_uc010zmj.1_Missense_Mutation_p.K645T|GIGYF2_uc002vtg.2_Missense_Mutation_p.K639T|GIGYF2_uc002vtj.3_Missense_Mutation_p.K666T|GIGYF2_uc002vtk.3_Missense_Mutation_p.K645T|GIGYF2_uc002vth.3_Missense_Mutation_p.K639T|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.K476T|GIGYF2_uc002vtq.3_5'UTR	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	645	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CAACAGCAGAAAGCAGCACTG	0.423		NA											7	60					0	0	0	0
ESPNL	339768	broad.mit.edu	37	2	239040108	239040108	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:239040108G>A	uc002vxq.3	+	9	2863	c.2753G>A	c.(2752-2754)GGC>GAC	p.G918D	ESPNL_uc010fyw.2_Missense_Mutation_p.G614D	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	918										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TGGACCGACGGCTTCGAGGAC	0.706		NA											3	35					0	0	0	0
ENTPD6	955	broad.mit.edu	37	20	25188018	25188018	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:25188018A>C	uc002wuj.2	+	3	541	c.361A>C	c.(361-363)ACC>CCC	p.T121P	ENTPD6_uc010zsy.1_Missense_Mutation_p.T121P|ENTPD6_uc010gdj.1_Missense_Mutation_p.T93P|ENTPD6_uc010zsz.1_Intron|ENTPD6_uc002wum.2_Missense_Mutation_p.T104P|ENTPD6_uc010zta.1_Missense_Mutation_p.T121P|ENTPD6_uc002wun.2_Missense_Mutation_p.T121P|ENTPD6_uc002wuk.2_Missense_Mutation_p.T120P|ENTPD6_uc002wul.2_Missense_Mutation_p.T120P|ENTPD6_uc010ztb.1_Missense_Mutation_p.T93P|ENTPD6_uc010ztc.1_Missense_Mutation_p.T93P|ENTPD6_uc002wuo.2_Intron|ENTPD6_uc010ztd.1_5'Flank	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	121	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						CTTCCAGTTCACCCGGCCCCC	0.587		NA											9	49					0	0	0	0
NINL	22981	broad.mit.edu	37	20	25456758	25456758	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:25456758C>T	uc002wux.1	-	17	3243	c.3169G>A	c.(3169-3171)GAC>AAC	p.D1057N	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1057	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GTTTCCATGTCATCCTTCTCT	0.532		NA											33	108					0	0	0	0
ZNF334	55713	broad.mit.edu	37	20	45131154	45131154	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:45131154C>T	uc002xsc.2	-	5	1008	c.824G>A	c.(823-825)CGT>CAT	p.R275H	ZNF334_uc002xsa.2_Missense_Mutation_p.R298H|ZNF334_uc002xsb.2_Missense_Mutation_p.R237H|ZNF334_uc002xsd.2_Missense_Mutation_p.R237H|ZNF334_uc010ghl.2_Missense_Mutation_p.R274H	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	275	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				TGTCTTCACACGAAAAGTTTT	0.413		NA											15	113					0	0	0	0
ZNF831	128611	broad.mit.edu	37	20	57767313	57767313	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:57767313C>T	uc002yan.2	+	1	1239	c.1239C>T	c.(1237-1239)TCC>TCT	p.S413S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	413	Potential.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGCTCATCTCCCACAACCAGG	0.532		NA											5	17					0	0	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072462	17072462	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:17072462T>A	uc002zlp.1	-	1	1239	c.979A>T	c.(979-981)AGT>TGT	p.S327C		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	327					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AACACCTCACTCAGGTAAATG	0.577		NA											28	221					0	0	0	0
LZTR1	8216	broad.mit.edu	37	22	21348279	21348279	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:21348279A>G	uc002zto.2	+	13	1523	c.1420A>G	c.(1420-1422)ATC>GTC	p.I474V	LZTR1_uc002ztn.2_Missense_Mutation_p.I433V|LZTR1_uc011ahy.1_Missense_Mutation_p.I455V|LZTR1_uc010gsr.1_Missense_Mutation_p.I345V|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	474	BTB 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TCGCAGGAAGATCACGCAGGC	0.647		NA											6	31					0	0	0	0
AP1B1	162	broad.mit.edu	37	22	29754833	29754833	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:29754833T>A	uc003afj.2	-	5	591	c.407A>T	c.(406-408)TAT>TTT	p.Y136F	AP1B1_uc003afi.2_Missense_Mutation_p.Y136F|AP1B1_uc003afk.2_Missense_Mutation_p.Y136F|AP1B1_uc003afl.2_Missense_Mutation_p.Y136F	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	136					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CTTGCGCACATATGGATCCTC	0.602		NA											11	40					0	0	0	0
MPPED1	758	broad.mit.edu	37	22	43830954	43830954	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:43830954G>A	uc011apv.1	+	3	448	c.225G>A	c.(223-225)ATG>ATA	p.M75I	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.M75I|MPPED1_uc011apz.1_Missense_Mutation_p.M108I	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	75							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CTCCCTGCAGGGTGGACCCGG	0.647		NA											15	150					0	0	0	0
PLXNB2	23654	broad.mit.edu	37	22	50720046	50720046	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:50720046C>T	uc003bkv.3	-	21	3577	c.3471G>A	c.(3469-3471)CCG>CCA	p.P1157P	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Silent_p.P142P	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1157	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCGCTTGGGCGGGGGCTGCA	0.692		NA											10	67					0	0	0	0
LRRN1	57633	broad.mit.edu	37	3	3887531	3887531	+	Silent	SNP	G	G	C	rs147557425	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:3887531G>C	uc003bpt.3	+	2	1967	c.1206G>C	c.(1204-1206)CCG>CCC	p.P402P	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	402	LRRCT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GTGCCATGCCGCCCGAATATA	0.483		NA											26	79					0	0	0	0
SLC6A11	6538	broad.mit.edu	37	3	10974928	10974928	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:10974928G>A	uc003bvz.2	+	11	1497	c.1463G>A	c.(1462-1464)GGC>GAC	p.G488D		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	488	Helical; Name=10; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ATCTGCATCGGCTGGGTGTAT	0.582		NA											4	171					0	0	0	0
MITF	4286	broad.mit.edu	37	3	70008500	70008500	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:70008500C>T	uc003dnz.2	+	9	1206	c.1090C>T	c.(1090-1092)CGC>TGC	p.R364C	MITF_uc011bgb.1_Missense_Mutation_p.R312C|MITF_uc003doa.2_Missense_Mutation_p.R363C|MITF_uc003dob.2_Missense_Mutation_p.R348C|MITF_uc003dod.2_Missense_Mutation_p.R339C|MITF_uc003doe.2_Missense_Mutation_p.R257C|MITF_uc003dof.2_Missense_Mutation_p.R263C	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	370					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		AGAACAGCAACGCGCAAAAGA	0.463		NA	A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						8	35					0	0	0	0
OR5H14	403273	broad.mit.edu	37	3	97868271	97868271	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:97868271C>T	uc003dsg.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGTTTGTTCTCACAGGATTTT	0.403		NA											18	167					0	0	0	0
ABI3BP	25890	broad.mit.edu	37	3	100469363	100469363	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:100469363C>T	uc003dun.2	-	35	3289	c.3204G>A	c.(3202-3204)GGG>GGA	p.G1068G	ABI3BP_uc003duj.2_Silent_p.G648G|ABI3BP_uc003duk.2_Silent_p.G777G|ABI3BP_uc003dul.2_Silent_p.G898G|ABI3BP_uc011bhd.1_Silent_p.G1022G|ABI3BP_uc003dum.2_Silent_p.G479G	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	1068						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GAATTGTAGTCCCACATTCAT	0.388		NA											9	130					0	0	0	0
MORC1	27136	broad.mit.edu	37	3	108746688	108746688	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:108746688G>A	uc003dxl.2	-	17	1701	c.1614C>T	c.(1612-1614)AGC>AGT	p.S538S	MORC1_uc011bhn.1_Silent_p.S538S	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	538					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						GTGATATTGTGCTCATGGTGC	0.398		NA											17	79					0	0	0	0
DPPA2	151871	broad.mit.edu	37	3	109023367	109023367	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:109023367G>T	uc003dxo.2	-	7	1056	c.809C>A	c.(808-810)TCC>TAC	p.S270Y		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	270						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TATGCCTGGGGATGGGAAAAT	0.478		NA											17	53					9.17e-09	1.13e-08	1	0
DPPA4	55211	broad.mit.edu	37	3	109047778	109047778	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:109047778C>T	uc003dxq.3	-	6	892	c.837G>A	c.(835-837)CCG>CCA	p.P279P	DPPA4_uc011bho.1_Missense_Mutation_p.A181T	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	279						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CTTCAAGGTGCGGGGGTGGAA	0.463		NA											12	40					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414052	121414052	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:121414052G>C	uc003eei.3	-	13	5429	c.5303C>G	c.(5302-5304)TCT>TGT	p.S1768C	GOLGB1_uc010hrc.2_Missense_Mutation_p.S1773C|GOLGB1_uc003eej.3_Missense_Mutation_p.S1734C|GOLGB1_uc011bjm.1_Missense_Mutation_p.S1654C|GOLGB1_uc010hrd.1_Missense_Mutation_p.S1732C	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1768	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGCTTGTTTAGATACATTACC	0.393		NA											20	226					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155314050	155314050	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:155314050C>T	uc011bok.1	-	2	438	c.161G>A	c.(160-162)CGA>CAA	p.R54Q	PLCH1_uc011boj.1_Missense_Mutation_p.R54Q|PLCH1_uc011bol.1_Missense_Mutation_p.R36Q	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	54	PH.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCTAGAGGGTCGCCATCGGAG	0.498		NA											55	195					0	0	0	0
SI	6476	broad.mit.edu	37	3	164760860	164760860	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:164760860G>A	uc003fei.2	-	17	2053	c.1991C>T	c.(1990-1992)TCT>TTT	p.S664F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	664	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATATCCGTCAGAATTATGGTT	0.358		NA								HNSCC(35;0.089)			14	73					0	0	0	0
CCDC149	91050	broad.mit.edu	37	4	24854761	24854761	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:24854761T>C	uc011bxr.1	-	5	449	c.305A>G	c.(304-306)AAT>AGT	p.N102S	CCDC149_uc003grc.2_Missense_Mutation_p.N102S|CCDC149_uc003grb.2_RNA|CCDC149_uc003grd.2_Missense_Mutation_p.N102S|CCDC149_uc003gre.2_Missense_Mutation_p.N47S|CCDC149_uc011bxq.1_5'UTR	NM_173463	NP_775734	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149 isoform 1	102											0		Breast(46;0.173)				CAGATGTTTATTTCGGTCCTG	0.413		NA											16	83					0	0	0	0
PLK4	10733	broad.mit.edu	37	4	128807211	128807211	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:128807211A>T	uc003ifo.2	+	5	931	c.686A>T	c.(685-687)GAA>GTA	p.E229V	PLK4_uc011cgs.1_Missense_Mutation_p.E197V|PLK4_uc011cgt.1_Missense_Mutation_p.E188V	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	229	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GCAGATTATGAAATGCCATCT	0.398		NA											10	131					0	0	0	0
ZNF827	152485	broad.mit.edu	37	4	146807157	146807157	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:146807157C>T	uc003ikn.2	-	4	1468	c.1420G>A	c.(1420-1422)GTC>ATC	p.V474I	ZNF827_uc003ikm.2_Missense_Mutation_p.V474I|ZNF827_uc010iox.2_Missense_Mutation_p.V124I	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					GATCCCTTGACATCTGGGTCT	0.567		NA											9	65					0	0	0	0
FSTL5	56884	broad.mit.edu	37	4	162306902	162306902	+	Silent	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:162306902G>A	uc003iqh.2	-	16	2977	c.2541C>T	c.(2539-2541)GCC>GCT	p.A847A	FSTL5_uc003iqi.2_Silent_p.A846A|FSTL5_uc010iqv.2_Silent_p.A837A|uc010iqu.1_Intron	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	847						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AGGGTTTTTAGGCATCTCCAA	0.338		NA											10	81					0	0	0	0
ACSL1	2180	broad.mit.edu	37	4	185681655	185681655	+	Splice_Site	SNP	C	C	T	rs111329654		TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:185681655C>T	uc003iww.2	-	18	1933	c.1639_splice	c.e18-1	p.N547_splice	ACSL1_uc011ckm.1_Splice_Site_p.N376_splice|ACSL1_uc003iwt.1_Splice_Site_p.N547_splice|ACSL1_uc003iwu.1_Splice_Site_p.N547_splice|ACSL1_uc011ckn.1_Splice_Site_p.N513_splice|ACSL1_uc003iws.1_Splice_Site_p.N107_splice	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1						digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGGTGCCATTCTGTTGATCAG	0.403		NA											44	337					0	0	0	0
DHX29	54505	broad.mit.edu	37	5	54565331	54565331	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:54565331C>T	uc003jpx.2	-	21	3324	c.3204G>A	c.(3202-3204)CCG>CCA	p.P1068P	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1068							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GTTGGCCCAACGGAGTCAGTT	0.443		NA											7	32					0	0	0	0
IPO11	51194	broad.mit.edu	37	5	61779883	61779883	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:61779883C>G	uc003jtc.2	+	11	1258	c.1068C>G	c.(1066-1068)TTC>TTG	p.F356L	IPO11_uc011cqr.1_Missense_Mutation_p.F396L|IPO11_uc003jtb.1_Missense_Mutation_p.F356L	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	356	HEAT 3.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AGATGGCATTCTTCACATATC	0.353		NA											9	62					0	0	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603276	140603276	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:140603276G>A	uc003ljb.2	+	1	199	c.199G>A	c.(199-201)GTG>ATG	p.V67M	PCDHB14_uc011dal.1_Intron	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	67	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCCGGGTAGTGTCTGATGA	0.493		NA											14	106					0	0	0	0
POU4F3	5459	broad.mit.edu	37	5	145719962	145719962	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:145719962C>T	uc003loa.2	+	2	1061	c.972C>T	c.(970-972)AAC>AAT	p.N324N		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	324	Homeobox.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTTCTGCAACCAGAGACAGA	0.552		NA											7	74					0	0	0	0
KIAA0319	9856	broad.mit.edu	37	6	24564520	24564520	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:24564520G>C	uc011djo.1	-	15	2578	c.2341C>G	c.(2341-2343)CTG>GTG	p.L781V	KIAA0319_uc011djp.1_Missense_Mutation_p.L736V|KIAA0319_uc003neh.1_Missense_Mutation_p.L781V|KIAA0319_uc011djq.1_Missense_Mutation_p.L772V|KIAA0319_uc011djr.1_Missense_Mutation_p.L781V|KIAA0319_uc010jpt.1_Missense_Mutation_p.L192V	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	781	PKD 5.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CCCTCCACCAGATTCGTAAGC	0.567		NA											14	86					0	0	0	0
HIST1H2BE	8344	broad.mit.edu	37	6	26184294	26184294	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:26184294A>G	uc003ngt.2	+	1	271	c.271A>G	c.(271-273)ACC>GCC	p.T91A		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	91					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CTCGACCATCACCTCCAGGGA	0.607		NA											11	134					0	0	0	0
TRIM15	89870	broad.mit.edu	37	6	30140093	30140093	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:30140093G>A	uc010jrx.2	+	7	1844	c.1365G>A	c.(1363-1365)TGG>TGA	p.W455*		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	455	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding				0						TTGCCGTCTGGAAAAAAGGTT	0.637		NA											10	54					0	0	0	0
GLO1	2739	broad.mit.edu	37	6	38649810	38649810	+	Silent	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:38649810T>C	uc003ooc.2	-	5	566	c.444A>G	c.(442-444)AAA>AAG	p.K148K		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	148					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	TCTTCACAAATTTGACTCCCA	0.413		NA											10	75					0	0	0	0
ZNF318	24149	broad.mit.edu	37	6	43322834	43322834	+	Silent	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:43322834T>C	uc003oux.2	-	4	2316	c.2238A>G	c.(2236-2238)CCA>CCG	p.P746P	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	746					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TTGGGGCAGATGGGGCTGATG	0.512		NA											17	81					0	0	0	0
CRISP3	10321	broad.mit.edu	37	6	49704206	49704206	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:49704206A>G	uc003ozs.2	-	3	102	c.87T>C	c.(85-87)ACT>ACC	p.T29T		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	29					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTAACAAAGCAGTAAAAGCGG	0.378		NA											23	190					0	0	0	0
COL21A1	81578	broad.mit.edu	37	6	55925556	55925556	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:55925556C>T	uc003pcs.2	-	27	2622	c.2390G>A	c.(2389-2391)TGC>TAC	p.C797Y	COL21A1_uc010jzz.2_Missense_Mutation_p.C182Y|COL21A1_uc011dxg.1_Missense_Mutation_p.C170Y|COL21A1_uc011dxh.1_Missense_Mutation_p.C182Y|COL21A1_uc003pcr.2_Missense_Mutation_p.C154Y	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	797					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACATCTGTGCAAACTTGTCG	0.299		NA											7	66					0	0	0	0
FAM135A	57579	broad.mit.edu	37	6	71232224	71232224	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:71232224A>G	uc003pfj.2	+	11	1171	c.1038A>G	c.(1036-1038)AGA>AGG	p.R346R	FAM135A_uc003pfi.2_Silent_p.R346R|FAM135A_uc003pfh.2_Silent_p.R329R|FAM135A_uc003pfk.2_Silent_p.R372R|FAM135A_uc003pfl.2_Silent_p.R209R|FAM135A_uc003pfn.2_5'Flank|FAM135A_uc003pfo.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	346										central_nervous_system(1)	1						AGGTACGCAGATTTTCTGAGG	0.348		NA											14	144					0	0	0	0
SIM1	6492	broad.mit.edu	37	6	100838427	100838427	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:100838427T>C	uc003pqj.3	-	11	2318	c.2111A>G	c.(2110-2112)CAG>CGG	p.Q704R	SIM1_uc010kcu.2_Missense_Mutation_p.Q704R	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	704	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTCAAAATACTGCCGGTGAGA	0.448		NA											11	91					0	0	0	0
SIM1	6492	broad.mit.edu	37	6	100901656	100901656	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:100901656C>T	uc003pqj.3	-	2	447	c.240G>A	c.(238-240)CTG>CTA	p.L80L	SIM1_uc010kcu.2_Silent_p.L80L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	80	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GATGGGAGCCCAGTTCTCGGC	0.587		NA											15	92					0	0	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762312	130762312	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:130762312G>A	uc003qca.2	+	3	1616	c.745G>A	c.(745-747)GAC>AAC	p.D249N	TMEM200A_uc010kfh.2_Missense_Mutation_p.D249N|TMEM200A_uc010kfi.2_Missense_Mutation_p.D249N|TMEM200A_uc003qcb.2_Missense_Mutation_p.D249N	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	249	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TTTGCTCTCTGACAGCTCTGT	0.463		NA											10	82					0	0	0	0
AHI1	54806	broad.mit.edu	37	6	135778701	135778701	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:135778701A>G	uc003qgi.2	-	9	1466	c.1082T>C	c.(1081-1083)ATT>ACT	p.I361T	AHI1_uc003qgh.2_Missense_Mutation_p.I361T|AHI1_uc003qgj.2_Missense_Mutation_p.I361T|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.I361T	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	361						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TGGGTGAGAAATCATAAAATC	0.358		NA											15	64					0	0	0	0
TMEM106B	54664	broad.mit.edu	37	7	12258148	12258148	+	Splice_Site	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:12258148G>A	uc011jxk.1	+	4	681	c.281_splice	c.e4+1	p.T94_splice	TMEM106B_uc003ssh.2_Splice_Site_p.T94_splice	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B							integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		CAAGAAGAACGTAAGTGATTC	0.279		NA											10	30					0	0	0	0
ANKMY2	57037	broad.mit.edu	37	7	16640498	16640498	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:16640498T>C	uc003sti.2	-	10	1414	c.1214A>G	c.(1213-1215)AAG>AGG	p.K405R	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	405						cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ATTGGAATCCTTTTGAGAGAT	0.423		NA											15	52					0	0	0	0
BMPER	168667	broad.mit.edu	37	7	34118721	34118721	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:34118721G>A	uc011kap.1	+	12	1445	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	444	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AACGGCTCGCGCATCGCGCTC	0.662		NA											4	102					0	0	0	0
ELMO1	9844	broad.mit.edu	37	7	37264509	37264509	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:37264509C>T	uc003tfk.1	-	9	983	c.676G>A	c.(676-678)GGC>AGC	p.G226S	ELMO1_uc011kbc.1_Missense_Mutation_p.G130S|ELMO1_uc010kxg.1_Missense_Mutation_p.G226S	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	226					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						ATGAGCTGGCCGATGGTGATC	0.532		NA											24	73					0	0	0	0
HECW1	23072	broad.mit.edu	37	7	43581558	43581558	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:43581558A>G	uc003tid.1	+	26	4814	c.4209A>G	c.(4207-4209)TTA>TTG	p.L1403L	HECW1_uc011kbi.1_Silent_p.L1369L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1403	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGACATCTTAGACCTCACTT	0.378		NA											13	65					0	0	0	0
DBNL	28988	broad.mit.edu	37	7	44089842	44089842	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:44089842A>C	uc003tjp.3	+	2	200	c.102A>C	c.(100-102)GAA>GAC	p.E34D	DBNL_uc003tjn.2_5'UTR|DBNL_uc003tjo.3_Missense_Mutation_p.E34D|DBNL_uc003tjr.3_5'UTR|DBNL_uc003tjq.3_Missense_Mutation_p.E34D|DBNL_uc011kbm.1_Missense_Mutation_p.E34D|DBNL_uc011kbn.1_Intron|DBNL_uc011kbo.1_5'UTR|DBNL_uc011kbp.1_Missense_Mutation_p.E34D|DBNL_uc011kbq.1_5'UTR|DBNL_uc011kbr.1_5'UTR|DBNL_uc011kbs.1_5'Flank	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	34	ADF-H.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						TTACCTATGAAGGCAACAGCA	0.542		NA											3	121					0	0	0	0
STEAP4	79689	broad.mit.edu	37	7	87913347	87913347	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:87913347C>T	uc003ujs.2	-	2	343	c.238G>A	c.(238-240)GCA>ACA	p.A80T	STEAP4_uc010lek.2_Missense_Mutation_p.A80T|STEAP4_uc003ujt.2_Missense_Mutation_p.A80T	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	80					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CTGTGGATTGCTATGATTATG	0.413		NA											11	94					0	0	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965755	88965755	+	Missense_Mutation	SNP	C	C	A	rs76889726	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:88965755C>A	uc011khi.1	+	4	3997	c.3459C>A	c.(3457-3459)GAC>GAA	p.D1153E		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1153						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTCTCCTGACGAAATAGATA	0.418		NA								HNSCC(36;0.09)			6	64					5.94e-07	7.2e-07	1	0
ZAN	7455	broad.mit.edu	37	7	100358081	100358081	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:100358081G>A	uc003uwj.2	+	19	3929	c.3764G>A	c.(3763-3765)CGG>CAG	p.R1255Q	ZAN_uc003uwk.2_Missense_Mutation_p.R1255Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_5'Flank	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1255	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCAAGCGGGCGGTTTGTGGAG	0.587		NA											14	95					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	4494972	4494972	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr8:4494972C>G	uc011kwk.1	-	2	584	c.194G>C	c.(193-195)GGC>GCC	p.G65A		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	65	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATTGCGCTCGCCCGTGATGAT	0.473		NA											18	93					0	0	0	0
TRPA1	8989	broad.mit.edu	37	8	72938196	72938196	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr8:72938196A>G	uc003xza.2	-	25	3225	c.3050T>C	c.(3049-3051)TTC>TCC	p.F1017S	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1017	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TGTACTTACGAATAACATCCC	0.413		NA											7	57					0	0	0	0
CNGB3	54714	broad.mit.edu	37	8	87645051	87645051	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr8:87645051A>C	uc003ydx.2	-	11	1295	c.1249T>G	c.(1249-1251)TTA>GTA	p.L417V	CNGB3_uc010maj.2_Missense_Mutation_p.L279V	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	417	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						ATTTCAAATAAAGTTTGTGGT	0.343		NA											17	33					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77370356	77370356	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:77370356G>A	uc004ajl.1	-	28	5057	c.4819C>T	c.(4819-4821)CAG>TAG	p.Q1607*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.Q1602*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Nonsense_Mutation_p.Q558*|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Nonsense_Mutation_p.Q563*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1607	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GGATTCAACTGGTCACTCTGA	0.428		NA											3	81					0	0	0	0
C9orf3	84909	broad.mit.edu	37	9	97535328	97535328	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:97535328T>C	uc004ava.2	+	2	977	c.842T>C	c.(841-843)CTT>CCT	p.L281P	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.L281P|C9orf3_uc004auy.2_Missense_Mutation_p.L281P|C9orf3_uc004auz.1_Missense_Mutation_p.L281P	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	281					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AACAGGGCCCTTTTTCCATGC	0.463		NA											3	165					0	0	0	0
ZNF510	22869	broad.mit.edu	37	9	99522337	99522337	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:99522337T>C	uc004awn.1	-	6	964	c.775A>G	c.(775-777)ATT>GTT	p.I259V	ZNF510_uc004awo.1_Missense_Mutation_p.I259V	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	259	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				GCTTTTCCAATTTTATTACAT	0.303		NA											6	50					0	0	0	0
TEX10	54881	broad.mit.edu	37	9	103070951	103070951	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:103070951C>T	uc004bas.2	-	13	2511	c.2296G>A	c.(2296-2298)GTA>ATA	p.V766I	TEX10_uc011lvf.1_Missense_Mutation_p.V605I|TEX10_uc011lvg.1_Missense_Mutation_p.V769I	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	766						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TCAGGAATTACAGTCAACCCA	0.428		NA											15	55					0	0	0	0
ZNF483	158399	broad.mit.edu	37	9	114305147	114305147	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:114305147C>T	uc004bff.2	+	6	2156	c.1932C>T	c.(1930-1932)TTC>TTT	p.F644F	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	644	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AGAAAGCCTTCCCAACCCATT	0.388		NA											9	48					0	0	0	0
CRB2	286204	broad.mit.edu	37	9	126137517	126137517	+	Silent	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:126137517C>T	uc004bnx.1	+	12	3620	c.3528C>T	c.(3526-3528)CCC>CCT	p.P1176P		NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	1176	Extracellular (Potential).|EGF-like 15.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCACTCTCCCCTGTGAAGCCA	0.627		NA											8	91					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139400000	139400000	+	Nonsense_Mutation	SNP	C	C	A	rs147841035	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:139400000C>A	uc004chz.2	-	25	4348	c.4348G>T	c.(4348-4350)GAG>TAG	p.E1450*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.E680*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1450	Extracellular (Potential).|LNR 1.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TCGGGCAGCTCGCACGCCTCC	0.677		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	47					0.000442599	0.000520476	1	0
ALAS2	212	broad.mit.edu	37	X	55042039	55042039	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:55042039A>C	uc004dua.3	-	8	1278	c.1140T>G	c.(1138-1140)CAT>CAG	p.H380Q	ALAS2_uc004dub.3_Missense_Mutation_p.H367Q|ALAS2_uc004dud.3_Missense_Mutation_p.H343Q	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	380					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	TGTCAATCTTATGCATAATTC	0.517		NA											10	39					0	0	0	0
TAF1	6872	broad.mit.edu	37	X	70604857	70604857	+	Silent	SNP	A	A	G			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:70604857A>G	uc004dzu.3	+	14	2232	c.2181A>G	c.(2179-2181)ACA>ACG	p.T727T	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.T748T	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	727					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				ACTGCCATACATCTCCTTTCC	0.393		NA											11	38					0	0	0	0
RGAG1	57529	broad.mit.edu	37	X	109696314	109696314	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:109696314G>A	uc004eor.1	+	3	2715	c.2469G>A	c.(2467-2469)ATG>ATA	p.M823I	RGAG1_uc011msr.1_Missense_Mutation_p.M823I	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	823										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CTCCACAAATGACAGCCACAG	0.532		NA											31	91					0	0	0	0
ATP11C	286410	broad.mit.edu	37	X	138886713	138886713	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:138886713C>A	uc004faz.2	-	6	580	c.481G>T	c.(481-483)GAT>TAT	p.D161Y	ATP11C_uc004fba.2_Missense_Mutation_p.D161Y	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	161	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					AGAATAAGATCACAGGGAAAG	0.368		NA											17	81					1.56e-12	1.95e-12	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904539	144904539	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:144904539C>T	uc004fcd.2	+	5	1586	c.596C>T	c.(595-597)GCT>GTT	p.A199V	SLITRK2_uc010nsp.2_Missense_Mutation_p.A199V|SLITRK2_uc010nso.2_Missense_Mutation_p.A199V|SLITRK2_uc011mwq.1_Missense_Mutation_p.A199V|SLITRK2_uc011mwr.1_Missense_Mutation_p.A199V|SLITRK2_uc011mws.1_Missense_Mutation_p.A199V|SLITRK2_uc004fcg.2_Missense_Mutation_p.A199V|SLITRK2_uc011mwt.1_Missense_Mutation_p.A199V	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	199	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCCTTTTGCTGGCGTCCTT	0.483		NA											22	79					0	0	0	0
TAF10	6881	broad.mit.edu	37	11	6632171	6632173	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:6632171_6632173delCTT	uc001mej.1	-	5	662_664	c.637_639delAAG	c.(637-639)AAGdel	p.K213del		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	213					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGTAGTGCGGCTTCTTCACATTG	0.458		NA											17	126	---	---	---	---	NA	NA	NA	NA
CNPY3	10695	broad.mit.edu	37	6	42897358	42897360	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:42897358_42897360delTGC	uc003ota.3	+	1	499_501	c.50_52delTGC	c.(49-54)TTGCTG>TTG	p.17_18LL>L	CNPY3_uc003osy.2_RNA|CNPY3_uc003osz.2_In_Frame_Del_p.17_18LL>L|CNPY3_uc003otc.3_5'UTR|CNPY3_uc003otb.3_5'UTR	NM_006586	NP_006577	Q9BT09	CNPY3_HUMAN	trinucleotide repeat containing 5 precursor	17_18					innate immune response	endoplasmic reticulum				ovary(1)	1	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTTCTTCCCTtgctgctgctgct	0.606		NA											6	6	---	---	---	---	NA	NA	NA	NA