Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ANGPTL7	10218	broad.mit.edu	37	1	11249656	11249656	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:11249656C>G	uc001ase.2	+	1	259	c.20C>G	c.(19-21)TCA>TGA	p.S7*	MTOR_uc001asd.2_Intron	NM_021146	NP_066969	O43827	ANGL7_HUMAN	angiopoietin-like 7 precursor	7					response to oxidative stress|signal transduction	extracellular region	receptor binding				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.39e-06)|COAD - Colon adenocarcinoma(227;0.000244)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0487)		AAGCCTCTCTCAGCTGTGACC	0.557		NA											18	138					0	0	0	0
VPS13D	55187	broad.mit.edu	37	1	12337106	12337106	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:12337106G>A	uc001atv.2	+	19	3602	c.3461G>A	c.(3460-3462)GGA>GAA	p.G1154E	VPS13D_uc001atw.2_Missense_Mutation_p.G1154E|VPS13D_uc001atx.2_Missense_Mutation_p.G342E	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1154					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGAGAACAAGGAACTTACCAG	0.393		NA											5	84					0	0	0	0
PADI3	51702	broad.mit.edu	37	1	17609457	17609457	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:17609457C>G	uc001bai.2	+	16	1918	c.1878C>G	c.(1876-1878)CTC>CTG	p.L626L		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	626					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CGCTGGGCCTCCACTGCACCT	0.587		NA											7	54					0	0	0	0
NFYC	4802	broad.mit.edu	37	1	41235027	41235027	+	Splice_Site	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:41235027G>A	uc001cge.2	+	9	894	c.886_splice	c.e9-1	p.I296_splice	NFYC_uc001cfx.3_Splice_Site_p.I296_splice|NFYC_uc009vwd.2_Splice_Site_p.I277_splice|NFYC_uc001cfz.2_Splice_Site_p.I277_splice|NFYC_uc010ojn.1_Splice_Site_p.I239_splice|NFYC_uc001cfy.3_Splice_Site_p.I277_splice|NFYC_uc001cgc.2_Splice_Site_p.I243_splice|NFYC_uc001cgb.2_Splice_Site_p.I277_splice|NFYC_uc001cgd.3_Splice_Site_p.I277_splice	NM_001142588	NP_001136060	Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma isoform 1						protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|kidney(1)	3	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			GATTCTTACAGATTACACAGA	0.463		NA											9	93					0	0	0	0
KDM4A	9682	broad.mit.edu	37	1	44137205	44137205	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:44137205G>A	uc001cjx.2	+	11	1559	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	465					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						AGTCAAATTTGAAGAGCTTAA	0.418		NA											13	110					0	0	0	0
RPS8	6202	broad.mit.edu	37	1	45243773	45243773	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:45243773G>A	uc001cmi.2	+	5	512	c.489G>A	c.(487-489)GAG>GAA	p.E163E	SNORD38B_uc001cml.2_5'Flank	NM_001012	NP_001003	P62241	RS8_HUMAN	ribosomal protein S8	163					endocrine pancreas development|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					GTCTCCTGGAGGAGCAGTTCC	0.448		NA											3	12					0	0	0	0
DNAJC6	9829	broad.mit.edu	37	1	65858191	65858191	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:65858191G>T	uc001dcd.1	+	12	1539	c.1375G>T	c.(1375-1377)GAA>TAA	p.E459*	DNAJC6_uc001dcc.1_Nonsense_Mutation_p.E490*|DNAJC6_uc010opc.1_Nonsense_Mutation_p.E446*|DNAJC6_uc001dce.1_Nonsense_Mutation_p.E516*	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	459					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						ATCAGATGATGAACTTCTGAC	0.512		NA											11	25					1.62e-10	1.76e-10	1	0
ODF2L	57489	broad.mit.edu	37	1	86852635	86852635	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:86852635C>G	uc001dll.1	-	2	416	c.76G>C	c.(76-78)GAT>CAT	p.D26H	ODF2L_uc001dlm.1_Missense_Mutation_p.D26H|ODF2L_uc001dln.2_Missense_Mutation_p.D26H|ODF2L_uc001dlo.2_5'UTR|ODF2L_uc001dlp.2_Missense_Mutation_p.D26H|ODF2L_uc010osg.1_Missense_Mutation_p.D26H|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	26						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CGTGGTAAATCTTCTTTCTCT	0.358		NA											7	68					0	0	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342038	94342038	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:94342038C>T	uc001dqf.2	-	2	1491	c.1453G>A	c.(1453-1455)GAC>AAC	p.D485N	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.D280N	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		AATGCATTGTCACATGACAGA	0.378		NA											23	41					0	0	0	0
GNAT2	2780	broad.mit.edu	37	1	110151357	110151357	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:110151357C>T	uc001dya.2	-	4	570	c.357G>A	c.(355-357)ATG>ATA	p.M119I		NM_005272	NP_005263	P19087	GNAT2_HUMAN	guanine nucleotide binding protein, alpha	119					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		GCTCAGGAGGCATGGTTCCCT	0.517		NA											21	49					0	0	0	0
SLC16A4	9122	broad.mit.edu	37	1	110921808	110921808	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:110921808C>T	uc001dzo.1	-	6	879	c.697G>A	c.(697-699)GAA>AAA	p.E233K	SLC16A4_uc009wfs.1_Missense_Mutation_p.E185K|SLC16A4_uc001dzp.1_Intron|SLC16A4_uc010ovy.1_Missense_Mutation_p.E171K|SLC16A4_uc001dzq.1_Intron|SLC16A4_uc010ovz.1_Missense_Mutation_p.E123K	NM_004696	NP_004687	O15374	MOT5_HUMAN	solute carrier family 16, member 4	233	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			ovary(3)	3		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	GTAGACTCTTCTGTCTCATGG	0.423		NA											39	90					0	0	0	0
CA14	23632	broad.mit.edu	37	1	150235226	150235226	+	Silent	SNP	T	T	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:150235226T>G	uc001etx.2	+	6	828	c.519T>G	c.(517-519)GCT>GCG	p.A173A		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	173	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGAATATAGCTTATGAACACA	0.363		NA											55	91					0	0	0	0
C1orf56	54964	broad.mit.edu	37	1	151021004	151021004	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:151021004C>A	uc001ewn.2	+	1	746	c.681C>A	c.(679-681)CAC>CAA	p.H227Q		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	227						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAAGCTGCACGGCCTTTCCG	0.652		NA									OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	83					4.16e-05	4.41e-05	1	0
FLG2	388698	broad.mit.edu	37	1	152324824	152324824	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:152324824G>A	uc001ezw.3	-	3	5511	c.5438C>T	c.(5437-5439)TCA>TTA	p.S1813L	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1813							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGAACCCTGAGTGCCCTTC	0.537		NA											61	149					0	0	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161166083	161166083	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:161166083C>A	uc001fyt.3	-	3	1396	c.968G>T	c.(967-969)GGA>GTA	p.G323V	ADAMTS4_uc001fyu.2_3'UTR	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	323	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGTGGAGACTCCACACAGGTC	0.597		NA											12	59					3.07e-06	3.27e-06	1	0
DDR2	4921	broad.mit.edu	37	1	162749994	162749994	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:162749994C>G	uc001gcf.2	+	19	2991	c.2526C>G	c.(2524-2526)TTC>TTG	p.F842L	DDR2_uc001gcg.2_Missense_Mutation_p.F842L|uc001gch.1_5'Flank	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	842	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GTCCCTCATTCCAAGAAATCC	0.522		NA											8	98					0	0	0	0
CFH	3075	broad.mit.edu	37	1	196658599	196658599	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:196658599G>A	uc001gtj.3	+	8	1254	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	CFH_uc001gti.3_Silent_p.E338E|CFH_uc009wyw.2_Intron|CFH_uc009wyx.2_Silent_p.E274E	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	338	Sushi 6.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TATATCATGAGAATATGCGTA	0.313		NA											12	62					0	0	0	0
ATP6V1G3	127124	broad.mit.edu	37	1	198509756	198509756	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:198509756G>A	uc001gup.2	-	2	131	c.25C>T	c.(25-27)CAC>TAC	p.H9Y	ATP6V1G3_uc009wzd.2_Missense_Mutation_p.H9Y|ATP6V1G3_uc001guo.2_Missense_Mutation_p.H9Y	NM_133262	NP_573569	Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal, V1 subunit	9	Potential.				cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)	1						AGAAGCTGGTGGATCCCCTGA	0.448		NA											43	70					0	0	0	0
KIF14	9928	broad.mit.edu	37	1	200549426	200549426	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:200549426C>G	uc010ppk.1	-	21	3860	c.3421G>C	c.(3421-3423)GAA>CAA	p.E1141Q	KIF14_uc010ppj.1_Missense_Mutation_p.E650Q	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1141	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TCAAACTTTTCCAGACTCCAG	0.264		NA											6	16					0	0	0	0
LMOD1	25802	broad.mit.edu	37	1	201868676	201868676	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:201868676T>G	uc001gxb.2	-	2	1713	c.1465A>C	c.(1465-1467)AAG>CAG	p.K489Q	LMOD1_uc010ppu.1_Missense_Mutation_p.K438Q	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	489					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						TTCTCTCCCTTGGCTTCCTGT	0.592		NA											11	16					0	0	0	0
C4BPA	722	broad.mit.edu	37	1	207286390	207286390	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:207286390C>T	uc001hfo.2	+	2	214	c.20C>T	c.(19-21)CCA>CTA	p.P7L		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	7					complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CCAAAAACTCCATCTGGGGCT	0.393		NA											16	32					0	0	0	0
MTR	4548	broad.mit.edu	37	1	236995364	236995364	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:236995364G>T	uc001hyi.3	+	13	1597	c.1174G>T	c.(1174-1176)GCA>TCA	p.A392S	MTR_uc010pxw.1_Intron|MTR_uc010pxx.1_Missense_Mutation_p.A392S|MTR_uc010pxy.1_Missense_Mutation_p.A392S	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	392	Pterin-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	ACTCATCATGGCAGGAAACTA	0.448		NA											6	48					2.01e-06	2.15e-06	1	0
EXO1	9156	broad.mit.edu	37	1	242045251	242045251	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:242045251C>T	uc001hzh.2	+	14	2683	c.2143C>T	c.(2143-2145)CAA>TAA	p.Q715*	EXO1_uc001hzi.2_Nonsense_Mutation_p.Q715*|EXO1_uc001hzj.2_Nonsense_Mutation_p.Q715*|EXO1_uc009xgq.2_Nonsense_Mutation_p.Q714*	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	715	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			ACTTGACAGTCAAAGTGACCA	0.279		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					4	44					0	0	0	0
OR2M2	391194	broad.mit.edu	37	1	248343777	248343777	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:248343777T>C	uc010pzf.1	+	1	490	c.490T>C	c.(490-492)TTT>CTT	p.F164L		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGTAGCCACATTTTCCTTCTC	0.418		NA											115	182					0	0	0	0
FBXO18	84893	broad.mit.edu	37	10	5956205	5956205	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:5956205C>T	uc001iis.2	+	8	1464	c.1369C>T	c.(1369-1371)CAG>TAG	p.Q457*	FBXO18_uc001iir.2_Nonsense_Mutation_p.Q383*|FBXO18_uc009xig.2_Nonsense_Mutation_p.Q383*|FBXO18_uc001iit.2_Nonsense_Mutation_p.Q508*	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	457					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GGAACCTCTCCAGGTGGTGAA	0.448		NA											9	86					0	0	0	0
APBB1IP	54518	broad.mit.edu	37	10	26789781	26789781	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:26789781A>G	uc001iss.2	+	5	515	c.194A>G	c.(193-195)GAT>GGT	p.D65G	APBB1IP_uc001isr.2_Missense_Mutation_p.D65G|APBB1IP_uc009xks.1_Missense_Mutation_p.D65G	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	65					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CAAGATTTAGATGCTCTCATG	0.403		NA											14	51					0	0	0	0
MASTL	84930	broad.mit.edu	37	10	27459563	27459563	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:27459563G>A	uc001itm.2	+	8	2314	c.1675G>A	c.(1675-1677)GAT>AAT	p.D559N	MASTL_uc001itl.2_Missense_Mutation_p.D559N|MASTL_uc009xkw.1_Missense_Mutation_p.D559N|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	559	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TTCTGATGATGATAGAGCTTC	0.333		NA											14	51					0	0	0	0
ANK3	288	broad.mit.edu	37	10	62029966	62029966	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:62029966T>C	uc001jky.2	-	5	628	c.436A>G	c.(436-438)ATG>GTG	p.M146V	ANK3_uc010qih.1_Missense_Mutation_p.M129V|ANK3_uc001jkz.3_Missense_Mutation_p.M140V|ANK3_uc001jlb.1_Translation_Start_Site	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	146	ANK 3.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGGGCTGCCATATACAATGGC	0.398		NA											19	33					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63816914	63816914	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:63816914G>C	uc001jlt.1	+	6	911	c.885G>C	c.(883-885)AAG>AAC	p.K295N	ARID5B_uc001jlu.1_Missense_Mutation_p.K52N	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	295					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CCAAGCCGAAGAATAACCATA	0.458		NA											18	22					0	0	0	0
HERC4	26091	broad.mit.edu	37	10	69699408	69699408	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:69699408G>A	uc001jng.3	-	22	2843	c.2532C>T	c.(2530-2532)AGC>AGT	p.S844S	HERC4_uc009xpq.2_Silent_p.S376S|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Silent_p.S836S|HERC4_uc009xpr.2_Intron|HERC4_uc001jni.3_Silent_p.S580S	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	844	HECT.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						ACTGTTGCATGCTTCTGCAAA	0.284		NA											10	34					0	0	0	0
HKDC1	80201	broad.mit.edu	37	10	71000451	71000451	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:71000451G>A	uc001jpf.3	+	6	768	c.635G>A	c.(634-636)GGG>GAG	p.G212E	HKDC1_uc010qje.1_Missense_Mutation_p.G75E	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	212					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						GACACCGTGGGGACCATGATG	0.562		NA											29	41					0	0	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143656	91143656	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:91143656G>A	uc001kgh.2	+	2	666	c.586G>A	c.(586-588)GGG>AGG	p.G196R	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	196	TPR 4.						binding				0						CACAGCATCAGGGAGGAATAA	0.453		NA											43	211					0	0	0	0
SMC3	9126	broad.mit.edu	37	10	112356208	112356208	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:112356208G>A	uc001kze.2	+	19	2142	c.2016G>A	c.(2014-2016)AGG>AGA	p.R672R		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	672	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		ATGACACAAGGAAGTCTCGAC	0.373		NA											28	53					0	0	0	0
EBF3	253738	broad.mit.edu	37	10	131641455	131641455	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:131641455C>T	uc001lki.1	-	12	1172	c.1113G>A	c.(1111-1113)CTG>CTA	p.L371L		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	380					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCGCCCGCTTCAGTAACACCT	0.602		NA											4	10					0	0	0	0
ECHS1	1892	broad.mit.edu	37	10	135176399	135176399	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:135176399C>G	uc001lmu.2	-	8	917	c.846G>C	c.(844-846)AAG>AAC	p.K282N		NM_004092	NP_004083	P30084	ECHM_HUMAN	mitochondrial short-chain enoyl-coenzyme A	282					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		TGGCCTTTCTCTTTTCCACAA	0.517		NA											4	75					0	0	0	0
TEAD1	7003	broad.mit.edu	37	11	12785959	12785959	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:12785959A>T	uc001mkj.3	+	3	800	c.135A>T	c.(133-135)TTA>TTT	p.L45F		NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	60	TEA.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		AAATCATCTTATCAGACGAAG	0.488		NA											23	42					0	0	0	0
CYP2R1	120227	broad.mit.edu	37	11	14907463	14907463	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:14907463T>A	uc001mlr.2	-	2	226	c.226A>T	c.(226-228)ATC>TTC	p.I76F	CYP2R1_uc001mlo.2_5'UTR|CYP2R1_uc001mlp.2_5'UTR|CYP2R1_uc001mlq.2_RNA|CYP2R1_uc001mls.1_Missense_Mutation_p.I21F	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	76					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	AAACTGAAGATCTTTGAGAAG	0.373		NA											14	33					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22248857	22248857	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:22248857G>C	uc001mqi.2	+	7	690	c.373G>C	c.(373-375)GAT>CAT	p.D125H	ANO5_uc001mqj.2_Missense_Mutation_p.D124H	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	125	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GGACTCGGAAGATGGAAGAAC	0.348		NA											38	97					0	0	0	0
OR4B1	119765	broad.mit.edu	37	11	48238839	48238839	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:48238839G>A	uc010rhs.1	+	1	478	c.478G>A	c.(478-480)GTT>ATT	p.V160I		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TCAGATTCTCGTTATCATCCA	0.468		NA											38	77					0	0	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653074	55653074	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:55653074A>C	uc010rip.1	+	2	262	c.170A>C	c.(169-171)AAG>ACG	p.K57T	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	57						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GAATGCAAGAAGACAACGCGG	0.512		NA											4	14					0	0	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735780	55735780	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:55735780G>C	uc010rit.1	-	1	160	c.160C>G	c.(160-162)CTT>GTT	p.L54V		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AAATTGCTAAGAAAAAAATAC	0.328		NA											15	81					0	0	0	0
INTS5	80789	broad.mit.edu	37	11	62416825	62416825	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:62416825G>A	uc001nud.2	-	2	780	c.727C>T	c.(727-729)CTC>TTC	p.L243F	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	243					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CCACAGGAGAGAACCCGGGAA	0.542		NA											21	50					0	0	0	0
NPAS4	266743	broad.mit.edu	37	11	66191403	66191403	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:66191403G>A	uc001ohx.1	+	7	1218	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	NPAS4_uc010rpc.1_Missense_Mutation_p.E138K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	348					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTCATTCCCTGAAAACATTCT	0.577		NA											29	181					0	0	0	0
ACER3	55331	broad.mit.edu	37	11	76709867	76709867	+	Splice_Site	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:76709867T>C	uc009yum.1	+	7	601	c.497_splice	c.e7+2	p.W166_splice	ACER3_uc010rsg.1_Splice_Site_p.W124_splice|ACER3_uc009yul.1_Splice_Site|ACER3_uc001oxu.2_Splice_Site|ACER3_uc009yun.1_Splice_Site_p.W124_splice|ACER3_uc009yuo.1_Splice_Site_p.W71_splice|ACER3_uc010rsh.1_Splice_Site_p.W129_splice|ACER3_uc010rsi.1_Splice_Site_p.W71_splice|ACER3_uc010rsj.1_Splice_Site_p.W71_splice	NM_018367	NP_060837	Q9NUN7	ACER3_HUMAN	phytoceramidase, alkaline						ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity				0						TGTTACATGGTAAGTAGTTTG	0.318		NA											7	29					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92624013	92624013	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:92624013G>A	uc001pdj.3	+	25	13425	c.13408G>A	c.(13408-13410)GAA>AAA	p.E4470K	FAT3_uc001pdi.3_Missense_Mutation_p.E942K	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4502	Pro-rich.|Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTCCCCAACGAAACGGATTT	0.592		NA								TCGA Ovarian(4;0.039)			17	29					0	0	0	0
SLC35F2	54733	broad.mit.edu	37	11	107676147	107676147	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:107676147C>T	uc001pjq.2	-	5	1090	c.669G>A	c.(667-669)CTG>CTA	p.L223L	SLC35F2_uc010rvu.1_Silent_p.L75L|SLC35F2_uc001pjs.2_3'UTR	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	223					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CCTGTCTGCTCAGCTTCTTCA	0.408		NA											5	46					0	0	0	0
SIK3	23387	broad.mit.edu	37	11	116729228	116729228	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:116729228G>C	uc001ppy.2	-	20	2671	c.2635C>G	c.(2635-2637)CAG>GAG	p.Q879E	SIK3_uc001ppz.2_Missense_Mutation_p.Q718E|SIK3_uc001pqa.2_Missense_Mutation_p.Q819E|SIK3_uc001ppw.2_Missense_Mutation_p.Q236E|SIK3_uc001ppx.2_Missense_Mutation_p.Q257E|SIK3_uc001pqb.2_Missense_Mutation_p.Q182E	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	879	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.R879R(1)		ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GGCGGCTGCTGATGTGCACTG	0.587		NA											12	107					0	0	0	0
OR6T1	219874	broad.mit.edu	37	11	123814028	123814028	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:123814028C>A	uc010sab.1	-	1	518	c.518G>T	c.(517-519)GGT>GTT	p.G173V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGGTCAATACCATTGGGGCC	0.562		NA											25	21					7.76e-22	8.56e-22	1	0
PRDM10	56980	broad.mit.edu	37	11	129780421	129780421	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:129780421G>A	uc001qfm.2	-	20	3357	c.3125C>T	c.(3124-3126)TCT>TTT	p.S1042F	PRDM10_uc001qfj.2_Missense_Mutation_p.S943F|PRDM10_uc001qfk.2_Missense_Mutation_p.S905F|PRDM10_uc001qfl.2_Missense_Mutation_p.S956F|PRDM10_uc010sbx.1_Missense_Mutation_p.S952F|PRDM10_uc001qfn.2_Missense_Mutation_p.S1038F	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1029	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GTGCTGCACAGAGGAATTctg	0.522		NA											11	45					0	0	0	0
IFLTD1	160492	broad.mit.edu	37	12	25702360	25702360	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:25702360A>T	uc001rgs.2	-	2	297	c.147T>A	c.(145-147)TAT>TAA	p.Y49*	IFLTD1_uc001rgt.1_5'UTR|IFLTD1_uc010sji.1_Nonsense_Mutation_p.Y70*|IFLTD1_uc010sjj.1_Intron|IFLTD1_uc009zjc.2_Nonsense_Mutation_p.Y70*	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	49						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GACTAGACAGATAGTAACCAA	0.398		NA											22	37					0	0	0	0
RASSF8	11228	broad.mit.edu	37	12	26217552	26217552	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:26217552C>G	uc001rgx.2	+	3	446	c.225C>G	c.(223-225)CTC>CTG	p.L75L	RASSF8_uc001rgy.2_Silent_p.L75L|RASSF8_uc001rgz.2_Silent_p.L75L|RASSF8_uc009zjd.1_Silent_p.L75L|RASSF8_uc009zje.1_Silent_p.L75L	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	75	Ras-associating.				signal transduction						0	Colorectal(261;0.0847)					ATGTGCAGCTCATTCTACGAC	0.463		NA											21	109					0	0	0	0
C12orf35	55196	broad.mit.edu	37	12	32135856	32135856	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:32135856C>T	uc001rks.2	+	4	2381	c.1967C>T	c.(1966-1968)TCA>TTA	p.S656L		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	656										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CAAGAATCCTCAACAAAAGGA	0.423		NA											6	59					0	0	0	0
NELL2	4753	broad.mit.edu	37	12	45173642	45173642	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:45173642C>T	uc001rog.2	-	4	1094	c.499G>A	c.(499-501)GAC>AAC	p.D167N	NELL2_uc001rof.3_Missense_Mutation_p.D166N|NELL2_uc001roh.2_Missense_Mutation_p.D167N|NELL2_uc009zkd.2_Missense_Mutation_p.D166N|NELL2_uc010skz.1_Missense_Mutation_p.D217N|NELL2_uc010sla.1_Missense_Mutation_p.D190N|NELL2_uc001roi.1_Missense_Mutation_p.D167N|NELL2_uc010slb.1_Missense_Mutation_p.D166N|NELL2_uc001roj.2_Missense_Mutation_p.D167N	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	167	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTATTGCAGTCAATGTGTAAA	0.403		NA											8	82					0	0	0	0
DDX23	9416	broad.mit.edu	37	12	49225034	49225034	+	Silent	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:49225034G>C	uc001rsm.2	-	16	2221	c.2130C>G	c.(2128-2130)CTC>CTG	p.L710L		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	710	Helicase C-terminal.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						CCCCAGCCTTGAGGTTGGACA	0.483		NA											19	146					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52099309	52099309	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:52099309G>A	uc001ryw.2	+	10	1421	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	SCN8A_uc010snl.1_Missense_Mutation_p.E280K|SCN8A_uc001ryx.1_Missense_Mutation_p.E280K|SCN8A_uc001ryz.1_Missense_Mutation_p.E280K|SCN8A_uc001ryy.2_Missense_Mutation_p.E280K	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	415	I.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CATGGCTTATGAAGAACAGAA	0.453		NA											4	33					0	0	0	0
MYF5	4617	broad.mit.edu	37	12	81112735	81112735	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:81112735C>A	uc001szg.2	+	3	808	c.673C>A	c.(673-675)CAG>AAG	p.Q225K		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	225					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GTTGCCTCTCCAGGATCTGGC	0.488		NA											25	60					7.42e-09	8e-09	1	0
CUX2	23316	broad.mit.edu	37	12	111785464	111785464	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:111785464G>A	uc001tsa.1	+	22	3949	c.3796G>A	c.(3796-3798)GAG>AAG	p.E1266K		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1266						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CTCTGAGACTGAGGACCAGAA	0.622		NA											11	32					0	0	0	0
TRIAP1	51499	broad.mit.edu	37	12	120882720	120882720	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:120882720C>T	uc001tyg.2	-	2	226	c.186G>A	c.(184-186)CTG>CTA	p.L62L	GATC_uc010szi.1_5'Flank	NM_016399	NP_057483	O43715	TRIA1_HUMAN	p53-inducible cell-survival factor	62					anti-apoptosis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	mitochondrion|perinuclear region of cytoplasm	caspase inhibitor activity|protein binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCATGAACTCCAGTCCTTCAA	0.403		NA											32	156					0	0	0	0
CLIP1	6249	broad.mit.edu	37	12	122794385	122794385	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:122794385G>T	uc001ucg.1	-	19	3624	c.3518C>A	c.(3517-3519)TCA>TAA	p.S1173*	CLIP1_uc001uch.1_Nonsense_Mutation_p.S1162*|CLIP1_uc001uci.1_Nonsense_Mutation_p.S1127*|CLIP1_uc001ucj.1_Nonsense_Mutation_p.S748*	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1173	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTGCAACGCTGAAAGCTGCTG	0.507		NA											19	39					6.94e-10	7.53e-10	1	0
DIAPH3	81624	broad.mit.edu	37	13	60557957	60557957	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr13:60557957C>A	uc001vht.2	-	13	1645	c.1426G>T	c.(1426-1428)GAT>TAT	p.D476Y	DIAPH3_uc001vhu.2_Missense_Mutation_p.D213Y|DIAPH3_uc001vhv.2_Missense_Mutation_p.D54Y	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	476	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AAGTCTGGATCCATTCCATCT	0.294		NA											31	68					3.04e-20	3.35e-20	1	0
NGDN	25983	broad.mit.edu	37	14	23945265	23945265	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:23945265G>A	uc001wjy.2	+	7	475	c.448G>A	c.(448-450)GAA>AAA	p.E150K	NGDN_uc001wjz.2_Missense_Mutation_p.E150K|NGDN_uc001wka.2_5'Flank	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	150	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GGAGGAAGATGAAGCAGAAGA	0.423		NA											5	61					0	0	0	0
RIN3	79890	broad.mit.edu	37	14	93118912	93118912	+	Silent	SNP	T	T	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:93118912T>A	uc001yap.2	+	6	1670	c.1518T>A	c.(1516-1518)TCT>TCA	p.S506S	RIN3_uc010auk.2_Silent_p.S168S|RIN3_uc001yaq.2_Silent_p.S431S|RIN3_uc001yar.1_Silent_p.S168S|RIN3_uc001yas.1_Silent_p.S168S	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	506	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GCCCTGCTTCTCAGGCTGGGA	0.652		NA											20	40					0	0	0	0
ATG2B	55102	broad.mit.edu	37	14	96807957	96807957	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:96807957C>T	uc001yfi.2	-	6	1191	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	276										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GGTGCTATCTCTGGTAAATTT	0.438		NA											16	82					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418065	105418066	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:105418065_105418066GC>AA	uc010axc.1	-	7	3842_3843	c.3722_3723GC>TT	c.(3721-3723)GGC>GTT	p.G1241V	AHNAK2_uc001ypx.2_Missense_Mutation_p.G1141V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1241						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCCTTTGAAGCCGGCTCCCTC	0.639		NA											78	36					0	0	0	0
MKRN3	7681	broad.mit.edu	37	15	23812217	23812217	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:23812217C>A	uc001ywh.3	+	1	1764	c.1288C>A	c.(1288-1290)CCT>ACT	p.P430T	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Intron	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	430						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGGAGATGAGCCTCCTGGGCC	0.522		NA											15	46					5.01e-05	5.3e-05	1	0
LCMT2	9836	broad.mit.edu	37	15	43622164	43622164	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:43622164G>A	uc001zrg.2	-	1	728	c.524C>T	c.(523-525)GCG>GTG	p.A175V	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	175					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GTCGAGCCCCGCGGCGCCCAG	0.716		NA											23	28					0	0	0	0
GNB5	10681	broad.mit.edu	37	15	52446255	52446255	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:52446255C>T	uc002abt.1	-	4	322	c.257G>A	c.(256-258)CGG>CAG	p.R86Q	GNB5_uc002abr.1_Missense_Mutation_p.R44Q|GNB5_uc002abs.1_Missense_Mutation_p.R44Q|GNB5_uc002abu.3_Missense_Mutation_p.R44Q	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	86						heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		GGCCTCCACCCGCTCCGCCAC	0.562		NA											9	29					0	0	0	0
MYO5A	4644	broad.mit.edu	37	15	52609388	52609388	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:52609388G>C	uc002aby.2	-	39	5435	c.5191C>G	c.(5191-5193)CGT>GGT	p.R1731G	MYO5A_uc002abx.3_Missense_Mutation_p.R1704G|MYO5A_uc010ugd.1_Missense_Mutation_p.R453G	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1731	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TTCTTGTCACGCAGCCATTCT	0.368		NA											7	50					0	0	0	0
LMAN1L	79748	broad.mit.edu	37	15	75105240	75105240	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:75105240C>G	uc002ayt.1	+	1	47	c.45C>G	c.(43-45)CTC>CTG	p.L15L	LMAN1L_uc010bkd.2_Intron|LMAN1L_uc010ulo.1_Intron|LMAN1L_uc010bke.1_Silent_p.L15L	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	15						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GCCTTCTCCTCCTGCTCCTGG	0.632		NA											33	60					0	0	0	0
LMAN1L	79748	broad.mit.edu	37	15	75105354	75105354	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:75105354C>T	uc002ayt.1	+	1	161	c.159C>T	c.(157-159)TTC>TTT	p.F53F	LMAN1L_uc010bkd.2_5'UTR|LMAN1L_uc010ulo.1_5'UTR|LMAN1L_uc010bke.1_Silent_p.F53F	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	53	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GAATACCCTTCTGGAGCCATC	0.617		NA											23	31					0	0	0	0
FURIN	5045	broad.mit.edu	37	15	91422758	91422758	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:91422758C>G	uc002bpu.1	+	10	1354	c.1138C>G	c.(1138-1140)CTC>GTC	p.L380V		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	380					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CATCATTGCTCTCACCCTGGA	0.627		NA											4	31					0	0	0	0
ST8SIA2	8128	broad.mit.edu	37	15	92981732	92981732	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:92981732C>T	uc002bra.2	+	4	595	c.440C>T	c.(439-441)TCG>TTG	p.S147L	ST8SIA2_uc002brb.2_Missense_Mutation_p.S126L	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	147	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CCCAGGACTTCGCCACTGAAG	0.537		NA											9	106					0	0	0	0
KIAA0556	23247	broad.mit.edu	37	16	27720105	27720105	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:27720105C>T	uc002dow.2	+	13	1493	c.1469C>T	c.(1468-1470)TCG>TTG	p.S490L	KIAA0556_uc002dox.1_Missense_Mutation_p.S398L	NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	490								p.S490S(1)		ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TGGGGCAACTCGTGGTGGGTG	0.483		NA											7	59					0	0	0	0
SLC5A2	6524	broad.mit.edu	37	16	31498885	31498885	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:31498885C>G	uc002ecf.3	+	7	709	c.690C>G	c.(688-690)TTC>TTG	p.F230L	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	230	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						CGGGTCTCTTCGACAAATACC	0.652		NA											4	85					0	0	0	0
CAPNS2	84290	broad.mit.edu	37	16	55601232	55601232	+	Silent	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:55601232A>G	uc002eid.1	+	1	649	c.564A>G	c.(562-564)CAA>CAG	p.Q188Q	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	188	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding				0						TAAATGAACAACTTTACCAAA	0.483		NA											47	88					0	0	0	0
ATMIN	23300	broad.mit.edu	37	16	81077197	81077197	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:81077197G>C	uc002ffz.1	+	4	1112	c.1094G>C	c.(1093-1095)AGC>ACC	p.S365T	ATMIN_uc002fga.2_Missense_Mutation_p.S207T|ATMIN_uc010vnn.1_Missense_Mutation_p.S136T|ATMIN_uc002fgb.1_Missense_Mutation_p.S207T	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	365	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						CTTAAGGAGAGCCTACCTCTT	0.458		NA											9	52					0	0	0	0
FANCA	2175	broad.mit.edu	37	16	89849296	89849296	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:89849296C>T	uc002fou.1	-	17	1639	c.1597G>A	c.(1597-1599)GAT>AAT	p.D533N	FANCA_uc010vpn.1_Missense_Mutation_p.D533N	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	533					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GATGACAAATCCTCGTAGAGT	0.488		NA	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				7	40					0	0	0	0
ACADVL	37	broad.mit.edu	37	17	7127131	7127131	+	Splice_Site	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:7127131G>A	uc002gev.2	+	13	1421	c.1270_splice	c.e13-1	p.E424_splice	ACADVL_uc010vtp.1_Splice_Site_p.E434_splice|ACADVL_uc002gew.2_Splice_Site_p.E402_splice|ACADVL_uc002gex.2_Splice_Site_p.E348_splice|uc002gey.1_5'Flank|MIR324_hsa-mir-324|MI0000813_5'Flank	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain						energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						TTTGTCCCTAGGAGGCAGCCT	0.557		NA											24	48					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	43					0	0	0	0
MFSD6L	162387	broad.mit.edu	37	17	8701980	8701980	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:8701980G>A	uc002glp.1	-	1	607	c.459C>T	c.(457-459)TTC>TTT	p.F153F		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	153						integral to membrane				central_nervous_system(1)	1						GTGGGTTTCTGAAGCCAGGCA	0.582		NA											11	93					0	0	0	0
FAM18B	51030	broad.mit.edu	37	17	18694255	18694255	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:18694255A>G	uc002gum.2	+	3	167	c.142A>G	c.(142-144)ATC>GTC	p.I48V	FAM18B_uc002gun.2_5'UTR	NM_016078	NP_057162	Q9NYZ1	F18B1_HUMAN	hypothetical protein LOC51030	48	Helical; (Potential).			I -> T (in Ref. 4; BAF83502).		integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (53;0.0872)|READ - Rectum adenocarcinoma(1115;0.0967)		AGTCAGTGCAATCATCGTCTA	0.393		NA											110	136					0	0	0	0
MYO18A	399687	broad.mit.edu	37	17	27442707	27442707	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:27442707C>T	uc002hdt.1	-	12	2360	c.2202G>A	c.(2200-2202)GAG>GAA	p.E734E	MYO18A_uc010wbc.1_Silent_p.E276E|MYO18A_uc002hds.2_Silent_p.E276E|MYO18A_uc010csa.1_Silent_p.E734E|MYO18A_uc002hdu.1_Silent_p.E734E|MYO18A_uc010wbd.1_Silent_p.E403E	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	734	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGCCACTCTCCTCGGGGCCCT	0.642		NA											7	6					0	0	0	0
WNK4	65266	broad.mit.edu	37	17	40947834	40947834	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:40947834G>C	uc002ibj.2	+	16	3235	c.3214G>C	c.(3214-3216)GAG>CAG	p.E1072Q	WNK4_uc010wgx.1_Missense_Mutation_p.E736Q|CCDC56_uc010wgz.1_Missense_Mutation_p.Q142E	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1072					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AGCTCTGGCTGAGAGCGACCG	0.607		NA											3	40					0	0	0	0
IMP5	162540	broad.mit.edu	37	17	43923106	43923106	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:43923106C>T	uc010wka.1	+	1	834	c.834C>T	c.(832-834)GTC>GTT	p.V278V	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	278	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		ACCACTTTGTCTATGTCACCA	0.592		NA											6	136					0	0	0	0
XYLT2	64132	broad.mit.edu	37	17	48432263	48432263	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:48432263G>C	uc002iqo.2	+	4	962	c.853G>C	c.(853-855)GAT>CAT	p.D285H	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	285	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					CCAGGGCTATGATAACGTGCG	0.642		NA											7	86					0	0	0	0
COLEC12	81035	broad.mit.edu	37	18	480723	480723	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr18:480723G>A	uc002kkm.2	-	2	257	c.42C>T	c.(40-42)TTC>TTT	p.F14F		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	14	Cytoplasmic (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GCTTGTAACCGAAGGATTGCA	0.552		NA											12	49					0	0	0	0
DSG2	1829	broad.mit.edu	37	18	29104495	29104495	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr18:29104495C>T	uc002kwu.3	+	7	963	c.775C>T	c.(775-777)CAG>TAG	p.Q259*		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	259	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGCTCAAGTTCAGATTCGTAT	0.343		NA											5	35					0	0	0	0
CDH20	28316	broad.mit.edu	37	18	59221721	59221721	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr18:59221721C>T	uc010dps.1	+	11	2211	c.2199C>T	c.(2197-2199)GCC>GCT	p.A733A	CDH20_uc002lif.2_Silent_p.A727A	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	733	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TCTACGAGGCCGACATGGACC	0.642		NA											3	33					0	0	0	0
MAP2K2	5605	broad.mit.edu	37	19	4101137	4101137	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:4101137C>G	uc002lzk.2	-	6	839	c.585G>C	c.(583-585)GTG>GTC	p.V195V	MAP2K2_uc002lzj.2_Silent_p.V5V	NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	195	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGGGCTTCACATCTGGAG	0.662		NA							Cardiofaciocutaneous_syndrome				6	13					0	0	0	0
TMEM146	257062	broad.mit.edu	37	19	5754220	5754220	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:5754220G>A	uc002mda.2	+	13	1303	c.1242G>A	c.(1240-1242)TCG>TCA	p.S414S	TMEM146_uc010duj.1_Silent_p.S72S	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	414	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGACTGCTTCGTTGATACCCC	0.453		NA											41	88					0	0	0	0
ACER1	125981	broad.mit.edu	37	19	6309843	6309843	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:6309843G>A	uc002mel.2	-	4	431	c.353C>T	c.(352-354)TCC>TTC	p.S118F		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	118	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GATGAACTGGGACCTGGGGAG	0.617		NA											6	32					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8618294	8618294	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:8618294C>G	uc002mkg.2	-	5	468	c.354G>C	c.(352-354)GTG>GTC	p.V118V	MYO1F_uc002mkh.2_Silent_p.V118V|MYO1F_uc010xkf.1_Silent_p.V118V	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	118	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						ATTTGGCTGCCACTGTCTTCC	0.512		NA											6	87					0	0	0	0
ZNF266	10781	broad.mit.edu	37	19	9528555	9528555	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:9528555A>T	uc002mll.2	-	2	330	c.64T>A	c.(64-66)TCT>ACT	p.S22T	ZNF266_uc002mlm.2_Missense_Mutation_p.S22T|ZNF266_uc002mln.2_Missense_Mutation_p.S22T|ZNF266_uc002mlo.2_Missense_Mutation_p.S22T|ZNF266_uc010dwp.2_Missense_Mutation_p.S22T|ZNF266_uc010dwq.2_Missense_Mutation_p.S22T	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCAGCCAAGAGATCAGACTG	0.438		NA											61	111					0	0	0	0
HOOK2	29911	broad.mit.edu	37	19	12878702	12878702	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:12878702G>A	uc002muy.2	-	13	1402	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	HOOK2_uc010xmq.1_5'Flank|HOOK2_uc002muz.2_Missense_Mutation_p.R411W	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	411	Sufficient for interaction with microtubules.|Potential.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						AAGGAGTCCCGCTCCGCCAAC	0.677		NA											21	22					0	0	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728925	15728925	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:15728925G>C	uc002nbi.2	+	3	377	c.313G>C	c.(313-315)GAC>CAC	p.D105H	CYP4F8_uc010xoi.1_Missense_Mutation_p.D105H|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	105					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						GTGCCACCCTGACATCGTCCG	0.577		NA											17	98					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40368715	40368715	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:40368715G>A	uc002omp.3	-	28	12641	c.12633C>T	c.(12631-12633)GGC>GGT	p.G4211G		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4211	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGCACACTGCGCCATGATAGC	0.597		NA											31	348					0	0	0	0
TSKS	60385	broad.mit.edu	37	19	50266447	50266447	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:50266447C>T	uc002ppm.2	-	1	69	c.58G>A	c.(58-60)GAC>AAC	p.D20N		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	20							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GTGGGGGTGTCCCCGGCCTCA	0.657		NA											16	74					0	0	0	0
RDH13	112724	broad.mit.edu	37	19	55559839	55559839	+	Silent	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:55559839G>C	uc002qio.3	-	5	701	c.516C>G	c.(514-516)CTC>CTG	p.L172L	RDH13_uc002qip.2_Silent_p.L101L|RDH13_uc010esr.1_RNA	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	172							binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	CCAGGGACGAGAGGTTGATGA	0.512		NA											5	67					0	0	0	0
ZNF211	10520	broad.mit.edu	37	19	58152803	58152803	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:58152803G>A	uc002qpq.2	+	3	1129	c.949G>A	c.(949-951)GAA>AAA	p.E317K	ZNF211_uc010yhb.1_Missense_Mutation_p.E321K|ZNF211_uc002qpp.2_Missense_Mutation_p.E330K|ZNF211_uc002qpr.2_Missense_Mutation_p.E381K|ZNF211_uc002qps.2_Missense_Mutation_p.E382K|ZNF211_uc002qpt.2_Missense_Mutation_p.E329K|ZNF211_uc010yhc.1_Missense_Mutation_p.E329K|ZNF211_uc010yhd.1_Missense_Mutation_p.E256K|ZNF211_uc010yhe.1_Missense_Mutation_p.E308K	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	317	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGCGTGCCCTGAATGTGGGAA	0.408		NA											18	79					0	0	0	0
ZNF274	10782	broad.mit.edu	37	19	58697098	58697098	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:58697098A>T	uc002qrq.1	+	3	512	c.53A>T	c.(52-54)GAT>GTT	p.D18V	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_Intron|ZNF274_uc002qrr.1_Missense_Mutation_p.D18V|ZNF274_uc002qrs.1_Intron|ZNF274_uc010eum.1_5'UTR	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	18	KRAB 1.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		ACCTTTGAAGATGTAACACTG	0.517		NA											42	65					0	0	0	0
KCNS3	3790	broad.mit.edu	37	2	18113159	18113159	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:18113159T>G	uc002rcv.2	+	3	1335	c.884T>G	c.(883-885)ATG>AGG	p.M295R	KCNS3_uc002rcw.2_Missense_Mutation_p.M295R	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	295	Helical; Name=Segment S4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTACGGCTTATGAGGATTTTC	0.498		NA											30	61					0	0	0	0
STRN	6801	broad.mit.edu	37	2	37126701	37126701	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:37126701C>T	uc002rpn.2	-	6	769	c.760G>A	c.(760-762)GAT>AAT	p.D254N	STRN_uc010ezx.2_Missense_Mutation_p.D254N	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	254					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TCTCTTCCATCAACATCATCA	0.338		NA											4	47					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44079964	44079964	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:44079964C>T	uc002rtq.2	+	6	1011	c.921C>T	c.(919-921)ATC>ATT	p.I307I	ABCG8_uc010yoa.1_Silent_p.I307I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	307	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCACAGCCATCGGCTACCCCT	0.592		NA											11	92					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44102445	44102445	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:44102445C>T	uc002rtq.2	+	11	1739	c.1649C>T	c.(1648-1650)GCG>GTG	p.A550V	ABCG8_uc010yoa.1_Missense_Mutation_p.A549V	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	550	Helical; Name=4; (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGCCGCCGCGGCCCTGCTC	0.617		NA											18	49					0	0	0	0
USP34	9736	broad.mit.edu	37	2	61431396	61431396	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:61431396T>C	uc002sbe.2	-	74	9401	c.9379A>G	c.(9379-9381)AGT>GGT	p.S3127G	USP34_uc002sbd.2_Intron	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3127					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CATACCTTACTGGTTTCCACC	0.428		NA											44	72					0	0	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530075	80530075	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:80530075G>T	uc002sok.1	-	2	1140	c.870C>A	c.(868-870)AAC>AAA	p.N290K	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	290	LRR 9.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AGGTGAGGCGGTTGGAGTCCA	0.602		NA								HNSCC(69;0.2)			13	32					1.57e-10	1.71e-10	1	0
SLC5A7	60482	broad.mit.edu	37	2	108604753	108604753	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:108604753G>A	uc002tdv.2	+	2	418	c.142G>A	c.(142-144)GAT>AAT	p.D48N	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.D48N|SLC5A7_uc010ywn.1_Intron	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	48	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TGGTGGCCGAGATATTGGTTT	0.527		NA											4	66					0	0	0	0
TTL	150465	broad.mit.edu	37	2	113251798	113251798	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:113251798C>G	uc002thu.2	+	3	494	c.315C>G	c.(313-315)CTC>CTG	p.L105L		NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	105	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		CAACCAATCTCAAGACTCCAG	0.443		NA	T	ETV6	ALL								10	52					0	0	0	0
UBXN4	23190	broad.mit.edu	37	2	136528186	136528186	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:136528186A>G	uc002tur.2	+	8	1014	c.703A>G	c.(703-705)ATG>GTG	p.M235V	UBXN4_uc002tus.2_Missense_Mutation_p.M1V	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	235	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						TGGAAAAGAAATGTTGGATTA	0.328		NA											8	13					0	0	0	0
FAP	2191	broad.mit.edu	37	2	163055300	163055300	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:163055300C>T	uc002ucd.2	-	16	1577	c.1369G>A	c.(1369-1371)GAC>AAC	p.D457N	FAP_uc010fpc.2_5'UTR|FAP_uc010zct.1_Missense_Mutation_p.D432N|FAP_uc010fpd.2_5'UTR	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	457	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TTGGCGTAGTCGCTGAAACTT	0.468		NA											20	41					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168103755	168103755	+	Silent	SNP	T	T	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:168103755T>G	uc002udx.2	+	8	5871	c.5853T>G	c.(5851-5853)GCT>GCG	p.A1951A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.A1776A|XIRP2_uc010fpq.2_Silent_p.A1729A|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1776					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATGCTAAAGCTGTGATGGCAG	0.403		NA											8	43					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179635006	179635006	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:179635006C>G	uc010zfg.1	-	36	8646	c.8422G>C	c.(8422-8424)GAA>CAA	p.E2808Q	TTN_uc010zfh.1_Missense_Mutation_p.E2762Q|TTN_uc010zfi.1_Missense_Mutation_p.E2762Q|TTN_uc010zfj.1_Missense_Mutation_p.E2762Q|TTN_uc002unb.2_Missense_Mutation_p.E2808Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2808							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGCATTTTCCAAGGCTGTC	0.408		NA											16	88					0	0	0	0
COL3A1	1281	broad.mit.edu	37	2	189873853	189873853	+	Silent	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:189873853A>G	uc002uqj.1	+	48	3846	c.3729A>G	c.(3727-3729)GGA>GGG	p.G1243G		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1243	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGTTAATGGACAAATAGAAA	0.423		NA											5	106					0	0	0	0
ANKAR	150709	broad.mit.edu	37	2	190559831	190559831	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:190559831C>G	uc002uqw.1	+	5	1219	c.1219C>G	c.(1219-1221)CAA>GAA	p.Q407E	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	478						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GACAGATGCTCAATTACATGA	0.338		NA											4	47					0	0	0	0
PLCL1	5334	broad.mit.edu	37	2	198949886	198949886	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:198949886G>C	uc010fsp.2	+	2	1936	c.1645G>C	c.(1645-1647)GAT>CAT	p.D549H	PLCL1_uc002uuv.3_Missense_Mutation_p.D470H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	549	Interaction with GABA A beta subunit (By similarity).				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TTCTGATCCAGATGTGTTAGA	0.413		NA											20	41					0	0	0	0
NOP58	51602	broad.mit.edu	37	2	203157551	203157551	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:203157551C>T	uc002uzb.2	+	9	982	c.832C>T	c.(832-834)CGA>TGA	p.R278*	SNORD11_uc002uzd.1_5'Flank	NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	278	Nop.				cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						TCTACAAAATCGAATGATGGC	0.358		NA											7	106					0	0	0	0
SPEG	10290	broad.mit.edu	37	2	220354138	220354138	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:220354138C>T	uc010fwg.2	+	36	8398	c.8398C>T	c.(8398-8400)CCT>TCT	p.P2800S		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2800	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCTGACTCTCCTACCTCACT	0.627		NA											4	15					0	0	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545520	234545520	+	Missense_Mutation	SNP	G	G	C	rs45458396		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:234545520G>C	uc002vur.2	+	1	398	c.352G>C	c.(352-354)GAC>CAC	p.D118H	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.D118H	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	118					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGTTTTCTTGACTTATTTTT	0.368		NA											13	106					0	0	0	0
SNX5	27131	broad.mit.edu	37	20	17937598	17937598	+	Silent	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:17937598G>C	uc002wqc.2	-	2	221	c.135C>G	c.(133-135)GTC>GTG	p.V45V	SNX5_uc002wqb.2_RNA|SNX5_uc002wqd.2_Silent_p.V45V|SNX5_uc002wqe.2_5'UTR|SNX5_uc010zrt.1_Silent_p.V45V	NM_014426	NP_055241	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	45	Phosphatidylinositol bisphosphate binding (By similarity).|PX.				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			large_intestine(1)	1						CTGTAAATTTGACTTTGTCTC	0.423		NA											16	57					0	0	0	0
ACSS1	84532	broad.mit.edu	37	20	25038407	25038407	+	Missense_Mutation	SNP	G	G	A	rs141662914		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:25038407G>A	uc002wub.2	-	1	1210	c.332C>T	c.(331-333)TCT>TTT	p.S111F	ACSS1_uc002wuc.2_Missense_Mutation_p.S111F|ACSS1_uc010gdc.2_Missense_Mutation_p.S111F	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	111					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCACTCACCAGAGACATTTAA	0.667		NA											7	47					0	0	0	0
NANP	140838	broad.mit.edu	37	20	25604531	25604531	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:25604531G>A	uc002wuy.2	-	1	118	c.54C>T	c.(52-54)ATC>ATT	p.I18I	uc002wuz.2_5'Flank	NM_152667	NP_689880	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	18					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity				0						CGGCCGTGTCGATGAGAGTGT	0.701		NA											4	26					0	0	0	0
ITCH	83737	broad.mit.edu	37	20	33045206	33045206	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:33045206G>A	uc010geu.1	+	14	1537	c.1345G>A	c.(1345-1347)GAC>AAC	p.D449N	ITCH_uc002xak.2_Missense_Mutation_p.D408N|ITCH_uc010zuj.1_Missense_Mutation_p.D298N	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	449	WW 3.|Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GAAGAGAACAGACAGCAATGG	0.403		NA											4	20					0	0	0	0
ADIG	149685	broad.mit.edu	37	20	37209995	37209995	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:37209995G>A	uc002xjb.1	+	1	158	c.102G>A	c.(100-102)TGG>TGA	p.W34*		NM_001018082	NP_001018092	Q0VDE8	ADIG_HUMAN	small adipocyte factor 1	34	Helical; (Potential).				brown fat cell differentiation|positive regulation of fat cell differentiation|white fat cell differentiation	cytoplasm|integral to membrane|nucleus					0		Myeloproliferative disorder(115;0.00878)				TGATCATCTGGCTACGCTTCT	0.517		NA											40	49					0	0	0	0
MAFB	9935	broad.mit.edu	37	20	39316788	39316788	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:39316788C>T	uc002xji.2	-	1	1089	c.703G>A	c.(703-705)GAG>AAG	p.E235K		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	235					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CGGATCACCTCGTCCTTGGTG	0.612		NA	T	IGH@	MM								5	12					0	0	0	0
ZNFX1	57169	broad.mit.edu	37	20	47863847	47863847	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:47863847G>A	uc002xui.2	-	14	5961	c.5714C>T	c.(5713-5715)GCC>GTC	p.A1905V		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1905							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CAGGTTGTTGGCCGTGTCAGA	0.522		NA											30	64					0	0	0	0
MYT1	4661	broad.mit.edu	37	20	62871203	62871203	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:62871203G>T	uc002yii.2	+	22	3548	c.3184G>T	c.(3184-3186)GGC>TGC	p.G1062C	MYT1_uc002yij.2_Missense_Mutation_p.G721C|MYT1_uc002yik.2_Missense_Mutation_p.G28C	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1062					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGAGCTGTCCGGCCTGAGCCA	0.592		NA											19	119					7.42e-09	8e-09	1	0
GABPA	2551	broad.mit.edu	37	21	27136626	27136626	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr21:27136626C>T	uc002ylx.3	+	8	1435	c.908C>T	c.(907-909)TCA>TTA	p.S303L	GABPA_uc002yly.3_Missense_Mutation_p.S303L	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	303					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						CCGAGGATTTCAGGAGAAGAT	0.338		NA											16	24					0	0	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744345	31744345	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr21:31744345G>A	uc002ynz.3	-	1	213	c.187C>T	c.(187-189)CCC>TCC	p.P63S		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	63	5 X 10 AA approximate repeats.|2.					intermediate filament					0						CAGCTGGTGGGCTCCCAGCAG	0.602		NA											23	43					0	0	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869589	22869589	+	Silent	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:22869589T>C	uc002zwe.2	-	2	619	c.366A>G	c.(364-366)GAA>GAG	p.E122E	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TATAACCAGGTTCAGATGAAG	0.483		NA											35	51					0	0	0	0
TST	7263	broad.mit.edu	37	22	37407100	37407100	+	Missense_Mutation	SNP	G	G	A	rs148918180	by1000genomes	TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:37407100G>A	uc003aqg.2	-	2	1562	c.862C>T	c.(862-864)CGT>TGT	p.R288C	TST_uc003aqh.2_Missense_Mutation_p.R288C	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	288	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						TGGGACACACGGCTCTCTGGG	0.617		NA											5	103					0	0	0	0
MICALL1	85377	broad.mit.edu	37	22	38323542	38323542	+	Silent	SNP	G	G	A	rs138192828		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:38323542G>A	uc003aui.2	+	9	1674	c.1590G>A	c.(1588-1590)CCG>CCA	p.P530P		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	530	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					TTCTGGAGCCGCCAGCTGTGC	0.657		NA											33	53					0	0	0	0
APOBEC3H	164668	broad.mit.edu	37	22	39497505	39497505	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:39497505C>T	uc011aoh.1	+	3	480	c.414C>T	c.(412-414)TTC>TTT	p.F138F	APOBEC3H_uc011aoi.1_5'Flank|APOBEC3H_uc003axa.3_5'Flank	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	138					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					TCATGGGCTTCCCAAGTAGGA	0.493		NA											13	47					0	0	0	0
CNTN6	27255	broad.mit.edu	37	3	1363508	1363508	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:1363508C>G	uc003boz.2	+	8	1203	c.936C>G	c.(934-936)CTC>CTG	p.L312L	CNTN6_uc011asj.1_Silent_p.L240L|CNTN6_uc003bpa.2_Silent_p.L312L	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	312					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGGGTCAACTCATTTTTTATG	0.348		NA											21	25					0	0	0	0
CAPN7	23473	broad.mit.edu	37	3	15276644	15276644	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:15276644G>C	uc003bzn.2	+	12	1669	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	calpain 7	467	Calpain catalytic.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1						GGATATTAGAGAGTTCAAGGT	0.393		NA											5	22					0	0	0	0
SATB1	6304	broad.mit.edu	37	3	18390856	18390856	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:18390856G>C	uc003cbh.2	-	11	3833	c.2098C>G	c.(2098-2100)CTC>GTC	p.L700V	SATB1_uc003cbi.2_Missense_Mutation_p.L732V|SATB1_uc003cbj.2_Missense_Mutation_p.L700V	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	700	Homeobox.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						TGGTGCTTGAGATAGTACCGC	0.507		NA											7	134					0	0	0	0
SNRK	54861	broad.mit.edu	37	3	43344765	43344765	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:43344765C>T	uc003cms.3	+	3	402	c.70C>T	c.(70-72)CGA>TGA	p.R24*	SNRK_uc003cmt.3_Nonsense_Mutation_p.R24*|SNRK_uc010hik.2_Nonsense_Mutation_p.R24*|SNRK_uc011azr.1_Intron|SNRK_uc003cmu.2_Nonsense_Mutation_p.R24*	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	24	ATP (By similarity).|Protein kinase.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		AACCTTGGGTCGAGGCCATTT	0.423		NA											22	27					0	0	0	0
MAP4	4134	broad.mit.edu	37	3	47957727	47957727	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:47957727G>A	uc003csb.2	-	7	2116	c.1590C>T	c.(1588-1590)CTC>CTT	p.L530L	MAP4_uc003csc.3_Silent_p.L530L|MAP4_uc011bbf.1_Silent_p.L507L|MAP4_uc003csf.3_Silent_p.L547L	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	530	17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CGTTCTTGATGAGAACTACTT	0.502		NA											36	33					0	0	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085380	64085380	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:64085380T>A	uc003dmf.2	-	8	2468	c.1882A>T	c.(1882-1884)ATT>TTT	p.I628F		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	628						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTGTAGCCAATGGGGTTGCTG	0.602		NA											35	34					0	0	0	0
CD80	941	broad.mit.edu	37	3	119246643	119246643	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:119246643C>T	uc003ecq.2	-	6	1237	c.842G>A	c.(841-843)AGA>AAA	p.R281K	CD80_uc010hqt.1_Missense_Mutation_p.R249K|CD80_uc010hqu.1_Missense_Mutation_p.R155K	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	281	Cytoplasmic (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	ACTTTCCCTTCTCAATCTCTC	0.453		NA											11	95					0	0	0	0
PODXL2	50512	broad.mit.edu	37	3	127379318	127379318	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:127379318G>A	uc003ejq.2	+	3	471	c.447G>A	c.(445-447)ATG>ATA	p.M149I		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	149	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						TGCCCAAGATGAATCTGGTTG	0.348		NA											17	68					0	0	0	0
ATP2C1	27032	broad.mit.edu	37	3	130714944	130714944	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:130714944C>T	uc003enl.2	+	23	2337	c.2115C>T	c.(2113-2115)TTC>TTT	p.F705F	ATP2C1_uc011blg.1_Silent_p.F739F|ATP2C1_uc011blh.1_Silent_p.F700F|ATP2C1_uc011bli.1_Silent_p.F739F|ATP2C1_uc003enk.2_Silent_p.F689F|ATP2C1_uc003enm.2_Silent_p.F705F|ATP2C1_uc003enn.2_Silent_p.F689F|ATP2C1_uc003eno.2_Silent_p.F705F|ATP2C1_uc003enp.2_Silent_p.F705F|ATP2C1_uc003enq.2_Silent_p.F705F|ATP2C1_uc003enr.2_Silent_p.F705F|ATP2C1_uc003ens.2_Silent_p.F705F|ATP2C1_uc003ent.2_Silent_p.F705F|ATP2C1_uc003enu.2_Silent_p.F383F	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	705	Helical; Name=5; (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TCGTTAGATTCCAGCTGAGCA	0.318		NA							Hailey-Hailey_disease				9	162					0	0	0	0
DNAJC13	23317	broad.mit.edu	37	3	132196904	132196904	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:132196904C>T	uc003eor.2	+	24	2694	c.2629C>T	c.(2629-2631)CTT>TTT	p.L877F		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	877							heat shock protein binding			ovary(1)|breast(1)	2						TTTACAAGCCCTTGCTATTGT	0.333		NA											22	92					0	0	0	0
RFC4	5984	broad.mit.edu	37	3	186507820	186507820	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:186507820C>G	uc003fqz.2	-	11	1253	c.1030G>C	c.(1030-1032)GAA>CAA	p.E344Q	RFC4_uc011bsc.1_Missense_Mutation_p.E344Q	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	344					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TGCAAATGTTCATCAGCACCA	0.378		NA											9	79					0	0	0	0
RFC4	5984	broad.mit.edu	37	3	186507847	186507847	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:186507847C>T	uc003fqz.2	-	11	1226	c.1003G>A	c.(1003-1005)GAC>AAC	p.D335N	RFC4_uc011bsc.1_Missense_Mutation_p.D335N	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	335					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		AGGCATTTGTCAACTTCCTAC	0.378		NA											9	71					0	0	0	0
EVC	2121	broad.mit.edu	37	4	5811288	5811288	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:5811288G>A	uc003gil.1	+	19	2916	c.2732G>A	c.(2731-2733)CGA>CAA	p.R911Q	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	911					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				GCCTTGGCCCGAGTGCCCCTT	0.433		NA											6	49					0	0	0	0
BOD1L	259282	broad.mit.edu	37	4	13606027	13606027	+	Missense_Mutation	SNP	C	C	T	rs79874260	by1000genomes	TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:13606027C>T	uc003gmz.1	-	10	2614	c.2497G>A	c.(2497-2499)GCT>ACT	p.A833T	BOD1L_uc010idr.1_Missense_Mutation_p.A170T	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	833	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GTTTTTTCAGCTGACAAGCGT	0.353		NA											6	17					0	0	0	0
UBA6	55236	broad.mit.edu	37	4	68543386	68543386	+	Silent	SNP	T	T	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:68543386T>A	uc003hdg.3	-	6	460	c.408A>T	c.(406-408)ACA>ACT	p.T136T	UBA6_uc003hdi.2_Silent_p.T136T|UBA6_uc003hdj.2_Silent_p.T136T	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	136					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						CAGAAGATGATGTGACATGAA	0.308		NA											28	38					0	0	0	0
C4orf7	260436	broad.mit.edu	37	4	71099858	71099858	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:71099858C>T	uc003hfd.2	+	4	297	c.212C>T	c.(211-213)CCA>CTA	p.P71L		NM_152997	NP_694542	Q8NFU4	FDSCP_HUMAN	chromosome 4 open reading frame 7 precursor	71	Pro-rich.					extracellular region				central_nervous_system(1)	1						TTTCCTATTCCAATACCTGAA	0.408		NA											42	85					0	0	0	0
G3BP2	9908	broad.mit.edu	37	4	76572243	76572243	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:76572243C>G	uc003hir.2	-	10	1192	c.1027G>C	c.(1027-1029)GAT>CAT	p.D343H	G3BP2_uc003his.2_Missense_Mutation_p.D343H|G3BP2_uc003hit.2_Missense_Mutation_p.D310H	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	343	RRM.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TCATTTTCATCAATATCATGT	0.338		NA											8	41					0	0	0	0
PTPN13	5783	broad.mit.edu	37	4	87671658	87671658	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:87671658G>A	uc003hpz.2	+	18	3166	c.2686G>A	c.(2686-2688)GAG>AAG	p.E896K	PTPN13_uc003hpy.2_Missense_Mutation_p.E896K|PTPN13_uc003hqa.2_Missense_Mutation_p.E896K|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	896						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCTCCAAGCAGAGTCTGTTAG	0.438		NA											9	176					0	0	0	0
RG9MTD2	93587	broad.mit.edu	37	4	100474995	100474995	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:100474995C>T	uc003huy.2	-	6	905	c.592G>A	c.(592-594)GAT>AAT	p.D198N	RG9MTD2_uc003huz.3_Missense_Mutation_p.D198N|RG9MTD2_uc003hva.3_Missense_Mutation_p.D198N	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	198							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		TTTGATTCATCTAATTCCTTC	0.323		NA											6	45					0	0	0	0
MFSD8	256471	broad.mit.edu	37	4	128878725	128878725	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:128878725C>G	uc003ifp.2	-	3	248	c.85G>C	c.(85-87)GAA>CAA	p.E29Q	MFSD8_uc011cgu.1_5'UTR|MFSD8_uc011cgv.1_Missense_Mutation_p.E29Q|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_5'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	29	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						TAATGCTCTTCAGTCTCTAAA	0.299		NA											15	92					0	0	0	0
FHDC1	85462	broad.mit.edu	37	4	153897181	153897181	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:153897181G>A	uc003inf.2	+	11	2813	c.2738G>A	c.(2737-2739)AGA>AAA	p.R913K		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	913					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AAGTCCAGCAGAGGCGCCGGC	0.672		NA											5	30					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155157796	155157796	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:155157796A>T	uc003inw.2	-	25	6643	c.6643T>A	c.(6643-6645)TAT>AAT	p.Y2215N		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2215	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGGTGTGATAGCTCAGGCTG	0.488		NA											4	69					0	0	0	0
FASTKD3	79072	broad.mit.edu	37	5	7867461	7867461	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:7867461C>T	uc003jeb.2	-	2	873	c.736G>A	c.(736-738)GAA>AAA	p.E246K	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	246					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TCCAATTTTTCACCTTGAAGT	0.373		NA											9	119					0	0	0	0
FASTKD3	79072	broad.mit.edu	37	5	7867642	7867642	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:7867642C>G	uc003jeb.2	-	2	692	c.555G>C	c.(553-555)CTG>CTC	p.L185L	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	185					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GCAACAGAATCAGAGCTTGCA	0.433		NA											10	127					0	0	0	0
FASTKD3	79072	broad.mit.edu	37	5	7867698	7867698	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:7867698C>G	uc003jeb.2	-	2	636	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	167					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GGCTCCTTTTCAAACTGAAAG	0.413		NA											8	108					0	0	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052056	9052056	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:9052056G>T	uc003jek.2	-	20	3486	c.2774C>A	c.(2773-2775)CCC>CAC	p.P925H		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	925	Extracellular (Potential).|TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GCTGCCCATGGGGAACAGGAG	0.572		NA											10	32					0.000978159	0.00101951	1	0
RANBP3L	202151	broad.mit.edu	37	5	36251470	36251470	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:36251470G>A	uc003jkh.2	-	13	1792	c.1299C>T	c.(1297-1299)TGC>TGT	p.C433C	RANBP3L_uc011cow.1_Silent_p.C458C	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	433					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CACAGCTTTCGCAGTTCAATT	0.373		NA											19	37					0	0	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407099	38407099	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:38407099A>G	uc003jlc.1	+	8	1322	c.998A>G	c.(997-999)AAG>AGG	p.K333R	EGFLAM_uc003jlb.1_Missense_Mutation_p.K333R|EGFLAM_uc003jle.1_Missense_Mutation_p.K99R|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	333						cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AGAAAGGGGAAGAATGGTGTG	0.532		NA											29	106					0	0	0	0
RICTOR	253260	broad.mit.edu	37	5	38944623	38944623	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:38944623C>T	uc003jlp.2	-	36	4862	c.4838G>A	c.(4837-4839)CGC>CAC	p.R1613H	RICTOR_uc003jlo.2_Missense_Mutation_p.R1637H|RICTOR_uc010ivf.2_Missense_Mutation_p.R1290H	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1613					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					AACTTCTTTGCGAAGGAGTAT	0.333		NA											28	86					0	0	0	0
ITGA2	3673	broad.mit.edu	37	5	52371079	52371079	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:52371079A>T	uc003joy.2	+	23	2913	c.2770A>T	c.(2770-2772)AAT>TAT	p.N924Y	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.N848Y|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	924	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CAAGGCTGATAATTTGGTCAA	0.368		NA											9	27					0	0	0	0
CCDC125	202243	broad.mit.edu	37	5	68616157	68616157	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:68616157C>G	uc003jvv.1	-	1	254	c.211G>C	c.(211-213)GAA>CAA	p.E71Q	CCDC125_uc003jvx.1_Missense_Mutation_p.E71Q|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_5'UTR|CCDC125_uc003jvz.1_Missense_Mutation_p.E71Q	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	71						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		AAACTCGCTTCATTTCTTTCT	0.388		NA											54	56					0	0	0	0
POLK	51426	broad.mit.edu	37	5	74879221	74879221	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:74879221C>G	uc003kdw.2	+	8	1134	c.1038C>G	c.(1036-1038)ATC>ATG	p.I346M	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003keb.2_Missense_Mutation_p.I346M|POLK_uc010izq.2_Intron|POLK_uc003kec.2_Missense_Mutation_p.I256M|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.I256M|POLK_uc003kee.2_Missense_Mutation_p.I346M|POLK_uc003kef.2_Missense_Mutation_p.I256M	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	346	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TGGACTTCATCAAGGATTTAC	0.323		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					17	37					0	0	0	0
SV2C	22987	broad.mit.edu	37	5	75490760	75490760	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:75490760C>T	uc003kei.1	+	3	731	c.597C>T	c.(595-597)CTC>CTT	p.L199L		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	199	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TAGTGTACCTCGGGATGATGG	0.468		NA											13	125					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79030703	79030703	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:79030703A>G	uc003kgc.2	+	2	6187	c.6115A>G	c.(6115-6117)AAA>GAA	p.K2039E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2039						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TAGCCAGGAAAAAATTAAACT	0.428		NA											23	22					0	0	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175902	140175902	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:140175902C>T	uc003lhd.2	+	1	1459	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.N451N|PCDHA2_uc011czy.1_Silent_p.N451N	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCGCCGGCGT	0.647		NA											39	44					0	0	0	0
PCDHB6	56130	broad.mit.edu	37	5	140529865	140529865	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:140529865G>C	uc003lir.2	+	1	27	c.27G>C	c.(25-27)AAG>AAC	p.K9N	PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	9					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACAGAACAAGAAAAGGCAAG	0.433		NA											15	57					0	0	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768638	140768638	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:140768638C>G	uc003lkc.1	+	1	1187	c.1187C>G	c.(1186-1188)TCA>TGA	p.S396*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Nonsense_Mutation_p.S396*	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	396	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAACTTCTTCAAGAAACACG	0.418		NA											6	77					0	0	0	0
RNF14	9604	broad.mit.edu	37	5	141353158	141353158	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:141353158C>T	uc003lly.2	+	2	44	c.5C>T	c.(4-6)TCG>TTG	p.S2L	RNF14_uc003llz.2_Missense_Mutation_p.S2L|RNF14_uc003lma.2_Missense_Mutation_p.S2L|RNF14_uc003lmb.2_5'UTR|RNF14_uc003lmc.2_Missense_Mutation_p.S2L|RNF14_uc011dbg.1_Missense_Mutation_p.S2L|RNF14_uc011dbh.1_Missense_Mutation_p.S2L|RNF14_uc003lmd.2_Missense_Mutation_p.S2L	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	2					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GTCCTTATGTCGTCAGAAGAT	0.328		NA											8	37					0	0	0	0
ABLIM3	22885	broad.mit.edu	37	5	148619423	148619423	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:148619423C>T	uc003lpy.2	+	13	1427	c.1176C>T	c.(1174-1176)TCC>TCT	p.S392S	ABLIM3_uc003lpz.1_Silent_p.S392S|ABLIM3_uc003lqa.1_Silent_p.S338S|ABLIM3_uc003lqb.2_Silent_p.S330S|ABLIM3_uc003lqc.1_Silent_p.S392S|ABLIM3_uc003lqd.1_Silent_p.S330S|ABLIM3_uc003lqf.2_Silent_p.S330S|ABLIM3_uc003lqe.1_Silent_p.S330S	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	392					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCTTCTCCCGCTCACCTC	0.627		NA											35	35					0	0	0	0
PDGFRB	5159	broad.mit.edu	37	5	149516593	149516593	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:149516593C>T	uc003lro.2	-	2	487	c.18G>A	c.(16-18)GCG>GCA	p.A6A	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Silent_p.A6A	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	6					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GAGCTGGCATCGCACCCGGAA	0.647		NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								3	21					0	0	0	0
GABRA1	2554	broad.mit.edu	37	5	161322867	161322867	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:161322867C>A	uc010jiw.2	+	10	1520	c.1052C>A	c.(1051-1053)CCA>CAA	p.P351Q	GABRA1_uc010jix.2_Missense_Mutation_p.P351Q|GABRA1_uc010jiy.2_Missense_Mutation_p.P351Q|GABRA1_uc003lyx.3_Missense_Mutation_p.P351Q|GABRA1_uc010jiz.2_Missense_Mutation_p.P351Q|GABRA1_uc010jja.2_Missense_Mutation_p.P351Q|GABRA1_uc010jjb.2_Missense_Mutation_p.P351Q	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	351	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGTGTGGTTCCAGAAAAGGTA	0.398		NA											31	35					4.75e-14	5.2e-14	1	0
BTNL9	153579	broad.mit.edu	37	5	180472573	180472573	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:180472573C>T	uc003mmt.2	+	2	315	c.84C>T	c.(82-84)CTC>CTT	p.L28L	BTNL9_uc011dhi.1_Intron	NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	28						integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCTCCTCCTCCTTCAGCCTG	0.607		NA											5	39					0	0	0	0
HIST1H2AB	8335	broad.mit.edu	37	6	26033738	26033738	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:26033738G>C	uc003nft.1	-	1	59	c.59C>G	c.(58-60)TCT>TGT	p.S20C	HIST1H3B_uc003nfs.1_5'Flank	NM_003513	NP_003504	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	20					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ACCTGCACGAGAAGACCGAGT	0.572		NA											5	106					0	0	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28215883	28215883	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:28215883C>G	uc003nks.1	-	3	860	c.616G>C	c.(616-618)GAT>CAT	p.D206H	ZKSCAN4_uc011dlb.1_Missense_Mutation_p.D51H	NM_019110	NP_061983	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	206					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ACCATTGCATCTTCTCTGCAG	0.572		NA											9	18					0	0	0	0
CYP21A2	1589	broad.mit.edu	37	6	31975151	31975151	+	Missense_Mutation	SNP	T	T	G	rs115914286	by1000genomes	TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:31975151T>G	uc010jtp.2	+	8	962	c.844T>G	c.(844-846)TTG>GTG	p.L282V	CYP21A2_uc011dpb.1_Missense_Mutation_p.L252V			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	281			V -> G (in AH3; salt wasting form).	V->I: Normal KM but 50% reduced Vmax.|V->T: Normal KM but 10% reduced Vmax.	glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						GGAAGGGCACTTGCACATGGC	0.607		NA											3	22					0	0	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169064	32169064	+	Silent	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:32169064C>G	uc003obb.2	-	22	4108	c.3969G>C	c.(3967-3969)CTG>CTC	p.L1323L	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1323	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GTCCTACCCTCAGAGTCAGGG	0.642		NA											7	67					0	0	0	0
SPDEF	25803	broad.mit.edu	37	6	34512160	34512160	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:34512160G>A	uc003ojq.1	-	2	488	c.73C>T	c.(73-75)CGG>TGG	p.R25W	SPDEF_uc011dsq.1_Missense_Mutation_p.R25W	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	25					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						AAGCCTGTCCGCGACACCGTG	0.716		NA											5	36					0	0	0	0
PRICKLE4	29964	broad.mit.edu	37	6	41753185	41753185	+	Silent	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:41753185G>C	uc011duf.1	+	6	737	c.489G>C	c.(487-489)CTG>CTC	p.L163L	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	123	LIM zinc-binding 1.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCAGGCCCTGATAAACCTCA	0.617		NA											5	58					0	0	0	0
PKHD1	5314	broad.mit.edu	37	6	51890330	51890330	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:51890330C>T	uc003pah.1	-	32	4554	c.4278G>A	c.(4276-4278)TCG>TCA	p.S1426S	PKHD1_uc003pai.2_Silent_p.S1426S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1426	IPT/TIG 9.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TAAAAGGACCCGAGAGGTCAA	0.537		NA											28	110					0	0	0	0
RAB23	51715	broad.mit.edu	37	6	57061369	57061369	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:57061369C>T	uc003pds.2	-	4	483	c.277G>A	c.(277-279)GAT>AAT	p.D93N	RAB23_uc003pdt.2_Missense_Mutation_p.D93N|RAB23_uc010kac.2_Missense_Mutation_p.D93N|RAB23_uc010kad.2_Intron	NM_183227	NP_899050	Q9ULC3	RAB23_HUMAN	Ras-related protein Rab-23	93					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GATTCCCTATCTGTGGTAGAG	0.353		NA											6	65					0	0	0	0
CD109	135228	broad.mit.edu	37	6	74516607	74516607	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:74516607C>G	uc003php.2	+	25	3426	c.3001C>G	c.(3001-3003)CCT>GCT	p.P1001A	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.P1001A|CD109_uc010kba.2_Missense_Mutation_p.P924A	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	1001						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TGAAGCCGATCCTTACATAGA	0.343		NA											4	30					0	0	0	0
ZNF292	23036	broad.mit.edu	37	6	87969609	87969609	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:87969609G>C	uc003plm.3	+	8	6303	c.6262G>C	c.(6262-6264)GAA>CAA	p.E2088Q		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2088					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GCATAAAAAAGAAAAGGAGGA	0.388		NA											7	45					0	0	0	0
CNR1	1268	broad.mit.edu	37	6	88853849	88853849	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:88853849C>A	uc011dzq.1	-	2	4708	c.1145G>T	c.(1144-1146)TGC>TTC	p.C382F	CNR1_uc010kbz.2_Missense_Mutation_p.C382F|CNR1_uc011dzr.1_Missense_Mutation_p.C382F|CNR1_uc011dzs.1_Missense_Mutation_p.C382F|CNR1_uc003pmq.3_Missense_Mutation_p.C382F|CNR1_uc011dzt.1_Missense_Mutation_p.C382F|CNR1_uc010kca.2_Missense_Mutation_p.C349F	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	382	Helical; Name=7; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GAGCATACTGCAGAATGCAAA	0.507		NA											18	49					3.52e-12	3.83e-12	1	0
PREP	5550	broad.mit.edu	37	6	105824004	105824004	+	Silent	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:105824004G>C	uc003prc.2	-	4	584	c.381C>G	c.(379-381)CTC>CTG	p.L127L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	127					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ACTTACCTCGGAGTGCCACTG	0.522		NA											17	38					0	0	0	0
REV3L	5980	broad.mit.edu	37	6	111697577	111697577	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:111697577C>T	uc003puy.3	-	13	2304	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	REV3L_uc003pux.3_Missense_Mutation_p.D583N|REV3L_uc003puz.3_Missense_Mutation_p.D583N	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	661					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCTTCATAATCAAAAATACTA	0.323		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	38					0	0	0	0
FYN	2534	broad.mit.edu	37	6	112035585	112035585	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:112035585A>T	uc003pvj.2	-	4	649	c.309T>A	c.(307-309)TTT>TTA	p.F103L	FYN_uc003pvi.2_Missense_Mutation_p.F103L|FYN_uc003pvk.2_Missense_Mutation_p.F103L|FYN_uc003pvh.2_Missense_Mutation_p.F103L	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	103	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	CTCCTTTGTGAAAACTCAGGT	0.428		NA											5	58					0	0	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378934	114378934	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:114378934G>A	uc003pwg.3	-	2	560	c.528C>T	c.(526-528)ATC>ATT	p.I176I	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Silent_p.I176I	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	176	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TCAACAACTTGATGGATGAGT	0.403		NA											43	247					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152770688	152770688	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:152770688C>G	uc010kiw.2	-	28	4086	c.3484G>C	c.(3484-3486)GAG>CAG	p.E1162Q	SYNE1_uc003qot.3_Missense_Mutation_p.E1169Q|SYNE1_uc003qou.3_Missense_Mutation_p.E1162Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E1145Q|SYNE1_uc003qow.2_Missense_Mutation_p.E457Q|SYNE1_uc003qox.1_Missense_Mutation_p.E678Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1162	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGTTTAACCTCTCCGTGGTTG	0.403		NA								HNSCC(10;0.0054)			25	46					0	0	0	0
DMTF1	9988	broad.mit.edu	37	7	86817567	86817567	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:86817567C>T	uc003uih.2	+	13	1687	c.1361C>T	c.(1360-1362)TCT>TTT	p.S454F	DMTF1_uc003uii.2_Missense_Mutation_p.S188F|DMTF1_uc003uij.2_Missense_Mutation_p.S188F|DMTF1_uc011khb.1_Missense_Mutation_p.S366F|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.S454F|DMTF1_uc003uin.2_Missense_Mutation_p.S188F	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	454	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					ACAGCCATCTCTTCTAGCCCC	0.423		NA											56	114					0	0	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87339931	87339931	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:87339931G>C	uc003ujb.2	+	5	880	c.469G>C	c.(469-471)GAA>CAA	p.E157Q	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.E140Q|RUNDC3B_uc011khe.1_Missense_Mutation_p.E140Q|RUNDC3B_uc003ujc.2_Missense_Mutation_p.E140Q|RUNDC3B_uc003ujd.2_Missense_Mutation_p.E62Q	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	157	RUN.									skin(1)	1	Esophageal squamous(14;0.00164)					ACATTTATCTGAATACATCTC	0.303		NA											14	29					0	0	0	0
MGC26647	219557	broad.mit.edu	37	7	88424117	88424117	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:88424117A>T	uc003ujv.2	-	2	322	c.140T>A	c.(139-141)CTT>CAT	p.L47H	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	47											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			CATCCTATCAAGAAGGAATTT	0.388		NA											40	97					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94043559	94043559	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:94043559C>A	uc003ung.1	+	29	2162	c.1691C>A	c.(1690-1692)GCT>GAT	p.A564D	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	564					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCAGGTCCCGCTGGTGAAGTT	0.433		NA								HNSCC(75;0.22)			7	33					3.1e-07	3.32e-07	1	0
NPTX2	4885	broad.mit.edu	37	7	98256519	98256519	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:98256519C>T	uc003upl.2	+	4	1108	c.931C>T	c.(931-933)CAC>TAC	p.H311Y		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	311	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CAAGTGGCACCACATCTGTGT	0.637		NA											19	30					0	0	0	0
SLC26A5	375611	broad.mit.edu	37	7	103017279	103017279	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:103017279A>G	uc003vbz.2	-	19	2253	c.2017T>C	c.(2017-2019)TAT>CAT	p.Y673H	SLC26A5_uc003vbt.1_Missense_Mutation_p.Y673H|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.Y641H|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	673	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						AAGTATACATATATACCGACG	0.313		NA											14	58					0	0	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117431659	117431659	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:117431659T>A	uc003vjf.2	-	4	1683	c.1591A>T	c.(1591-1593)ACT>TCT	p.T531S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	531	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ACACCATGAGTCTTTAAACTG	0.547		NA											42	79					0	0	0	0
RBM28	55131	broad.mit.edu	37	7	127964661	127964661	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:127964661C>G	uc003vmp.2	-	12	1405	c.1290G>C	c.(1288-1290)AAG>AAC	p.K430N	RBM28_uc003vmo.2_Missense_Mutation_p.K47N|RBM28_uc011koj.1_Missense_Mutation_p.K289N|RBM28_uc011kok.1_Missense_Mutation_p.K377N	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	430					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						GCTTCTTCACCTTCGTCGTCT	0.557		NA											26	207					0	0	0	0
AHCYL2	23382	broad.mit.edu	37	7	129028933	129028933	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:129028933C>T	uc011kov.1	+	3	566	c.512C>T	c.(511-513)TCG>TTG	p.S171L	AHCYL2_uc003vot.2_Missense_Mutation_p.S170L|AHCYL2_uc003vov.2_Missense_Mutation_p.S68L|AHCYL2_uc011kow.1_Missense_Mutation_p.S69L|AHCYL2_uc011kox.1_Missense_Mutation_p.S68L	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	171					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GATGAGACATCGCCCAGGGAC	0.398		NA											19	49					0	0	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138774437	138774437	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:138774437A>T	uc003vun.2	-	2	765	c.377T>A	c.(376-378)CTC>CAC	p.L126H	ZC3HAV1_uc003vup.2_Missense_Mutation_p.L126H	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	126					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CAGTCCAGAGAGTTCGTGATT	0.408		NA											26	11					0	0	0	0
MTMR9	66036	broad.mit.edu	37	8	11172549	11172549	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:11172549C>T	uc003wtm.2	+	7	1487	c.1089C>T	c.(1087-1089)GCC>GCT	p.A363A	MTMR9_uc010lrx.2_Silent_p.A256A|MTMR9_uc011kxa.1_Silent_p.A278A	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	363	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		GTTTTGAGGCCCTGATTGAAA	0.483		NA											48	114					0	0	0	0
BIN3	55909	broad.mit.edu	37	8	22487967	22487967	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:22487967G>T	uc003xcl.2	-	5	382	c.285C>A	c.(283-285)TTC>TTA	p.F95L	BIN3_uc003xck.2_Missense_Mutation_p.F47L|BIN3_uc010ltw.2_Missense_Mutation_p.F41L	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	95	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		TTTCCTGATTGAAGGCATCCA	0.592		NA											36	186					3.62e-18	3.98e-18	1	0
NEFM	4741	broad.mit.edu	37	8	24771655	24771655	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:24771655G>C	uc003xed.3	+	1	382	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	NEFM_uc011lac.1_Missense_Mutation_p.E117Q|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	117	Rod.|Coil 1A.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CGGCTACATAGAGAAGGTGCA	0.647		NA											3	13					0	0	0	0
DCTN6	10671	broad.mit.edu	37	8	30038087	30038087	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:30038087G>C	uc003xhy.2	+	6	502	c.415G>C	c.(415-417)GAG>CAG	p.E139Q		NM_006571	NP_006562	O00399	DCTN6_HUMAN	dynactin 6	139						centrosome	transferase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.099)|Kidney(114;0.119)		AGTCATCCCTGAGAATACGGT	0.438		NA											10	43					0	0	0	0
RBPMS	11030	broad.mit.edu	37	8	30402106	30402106	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:30402106C>G	uc003xic.1	+	6	1158	c.493C>G	c.(493-495)CCT>GCT	p.P165A	RBPMS_uc003xid.1_Missense_Mutation_p.P165A|RBPMS_uc003xie.1_Missense_Mutation_p.P165A|RBPMS_uc003xif.1_RNA|RBPMS_uc011lba.1_Missense_Mutation_p.P165A|RBPMS_uc003xib.2_Missense_Mutation_p.P165A|RBPMS_uc010lvh.1_Missense_Mutation_p.P61A	NM_006867	NP_006858	Q93062	RBPMS_HUMAN	RNA-binding protein with multiple splicing	165					positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		TCTACCTCCTCCTGCTTTCAC	0.562		NA											8	159					0	0	0	0
PURG	29942	broad.mit.edu	37	8	30889927	30889927	+	Silent	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:30889927C>T	uc003xin.2	-	1	391	c.372G>A	c.(370-372)GAG>GAA	p.E124E	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Silent_p.E124E	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	124	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		GGGCATAGTGCTCGATGAAGT	0.597		NA											15	92					0	0	0	0
RB1CC1	9821	broad.mit.edu	37	8	53569790	53569790	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:53569790G>C	uc003xre.3	-	15	3157	c.2599C>G	c.(2599-2601)CTA>GTA	p.L867V	RB1CC1_uc003xrf.3_Missense_Mutation_p.L867V	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	867	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AAAGACAGTAGTTCTTTTTGA	0.264		NA											7	33					0	0	0	0
MOS	4342	broad.mit.edu	37	8	57025630	57025630	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:57025630G>A	uc011leb.1	-	1	912	c.912C>T	c.(910-912)TTC>TTT	p.F304F		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	304	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCGAGTCCTCGAAGACGGCAG	0.682		NA											6	29					0	0	0	0
CSPP1	79848	broad.mit.edu	37	8	68028195	68028195	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:68028195A>G	uc003xxi.2	+	13	1455	c.1424A>G	c.(1423-1425)GAG>GGG	p.E475G	CSPP1_uc003xxg.1_Missense_Mutation_p.E467G|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.E440G|CSPP1_uc003xxk.2_Missense_Mutation_p.E146G	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	475						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			CACTTTGAAGAGATGATACCA	0.408		NA											37	81					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95504890	95504890	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:95504890T>C	uc003ygo.1	-	21	4811	c.4798A>G	c.(4798-4800)ATA>GTA	p.I1600V	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1600					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTTGACGTTATAAAGGTCTCA	0.338		NA											10	74					0	0	0	0
IFNA8	3445	broad.mit.edu	37	9	21409512	21409512	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:21409512G>C	uc003zpc.1	+	1	367	c.337G>C	c.(337-339)GAC>CAC	p.D113H		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	113					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		CATCGAACTTGACCAGCAGCT	0.502		NA											26	45					0	0	0	0
RGP1	9827	broad.mit.edu	37	9	35751957	35751957	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:35751957C>T	uc011lpf.1	+	8	908	c.767C>T	c.(766-768)TCA>TTA	p.S256L	GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Missense_Mutation_p.S296L	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	256										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCCCAGTTTTCAGTCAGCTTA	0.577		NA											5	24					0	0	0	0
CBWD6	644019	broad.mit.edu	37	9	69238279	69238279	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:69238279T>C	uc004afj.3	-	8	719	c.613A>G	c.(613-615)ACA>GCA	p.T205A	CBWD6_uc004afk.3_Intron|CBWD6_uc011lrf.1_Intron	NM_001085457	NP_001078926	Q4V339	CBWD6_HUMAN	COBW domain containing 6	205	ATP (Potential).						ATP binding				0						ACCAAGTCTGTTTTATTAATG	0.313		NA											35	110					0	0	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71606110	71606110	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:71606110G>A	uc004agu.2	+	15	1862	c.1557G>A	c.(1555-1557)TTG>TTA	p.L519L	PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	519						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CCATCTACTTGACCGCTGAGC	0.448		NA											9	95					0	0	0	0
FAM120A	23196	broad.mit.edu	37	9	96291798	96291798	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:96291798G>C	uc004atw.2	+	9	1695	c.1670G>C	c.(1669-1671)AGA>ACA	p.R557T	FAM120A_uc004atv.2_Missense_Mutation_p.R557T|FAM120A_uc004atx.2_Missense_Mutation_p.R339T|FAM120A_uc004aty.2_Missense_Mutation_p.R338T|FAM120A_uc004atz.2_Missense_Mutation_p.R206T|FAM120A_uc010mrf.1_RNA|FAM120A_uc010mrg.2_5'Flank	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	557						cytoplasm|plasma membrane	RNA binding				0						GAGGTGCTGAGAGTGGCCGAG	0.592		NA											15	65					0	0	0	0
FAM120A	23196	broad.mit.edu	37	9	96320925	96320925	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:96320925C>T	uc004atw.2	+	15	2756	c.2731C>T	c.(2731-2733)CGT>TGT	p.R911C	FAM120A_uc004aty.2_Missense_Mutation_p.R692C|FAM120A_uc004atz.2_Missense_Mutation_p.R560C|FAM120A_uc010mrg.2_Intron	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	911	RNA binding.					cytoplasm|plasma membrane	RNA binding				0						CCGTGCCTTCCGTGTGGCGGC	0.612		NA											18	96					0	0	0	0
RBM18	92400	broad.mit.edu	37	9	125004258	125004258	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:125004258C>G	uc004bma.2	-	6	644	c.478G>C	c.(478-480)GAG>CAG	p.E160Q	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	160							nucleotide binding|RNA binding				0						GCTGGATACTCTGCATCAGGA	0.408		NA											13	78					0	0	0	0
COL5A1	1289	broad.mit.edu	37	9	137623932	137623932	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:137623932G>T	uc004cfe.2	+	9	1730	c.1348G>T	c.(1348-1350)GGC>TGC	p.G450C		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	450	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGACCTCGGGGCGAGAAAGG	0.527		NA											67	56					7.07e-35	7.82e-35	1	0
MAMDC4	158056	broad.mit.edu	37	9	139751179	139751179	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:139751179G>A	uc004cjs.2	+	15	1788	c.1738G>A	c.(1738-1740)GAG>AAG	p.E580K	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	659	MAM 4.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTGTAACTTTGAGCGGGACAC	0.662		NA											10	23					0	0	0	0
PPP2R3B	28227	broad.mit.edu	37	X	306382	306382	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:306382G>A	uc004cpg.2	-	7	1106	c.905C>T	c.(904-906)GCG>GTG	p.A302V	PPP2R3B_uc011mha.1_Missense_Mutation_p.A141V	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	302					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTTGATGTCCGCCTCCTCCTC	0.637		NA											19	45					0	0	0	0
CSF2RA	1438	broad.mit.edu	37	X	1407734	1407734	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:1407734G>A	uc010nct.2	+	7	748	c.426G>A	c.(424-426)CCG>CCA	p.P142P	CSF2RA_uc011mhb.1_Silent_p.P142P|CSF2RA_uc004cpq.2_Silent_p.P142P|CSF2RA_uc004cpn.2_Silent_p.P142P|CSF2RA_uc004cpo.2_Silent_p.P142P|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.P9P|CSF2RA_uc004cpp.2_Silent_p.P142P|CSF2RA_uc010ncv.2_Silent_p.P142P|CSF2RA_uc004cpr.2_Silent_p.P142P	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	142	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CGAGGGGTCCGACGGCCCCCC	0.478		NA											53	68					0	0	0	0
PIGA	5277	broad.mit.edu	37	X	15349714	15349714	+	Silent	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:15349714G>A	uc004cwr.2	-	2	439	c.339C>T	c.(337-339)CTC>CTT	p.L113L	PIGA_uc004cwq.2_5'UTR|PIGA_uc010nev.2_Silent_p.L113L|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Silent_p.L113L	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	113	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					ATATGTACCTGAGCAATGGCA	0.478		NA											43	10					0	0	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19568091	19568091	+	Splice_Site	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:19568091C>T	uc004czm.2	-	14	1810	c.1494_splice	c.e14+1	p.S498_splice	SH3KBP1_uc011mje.1_Splice_Site_p.S237_splice|SH3KBP1_uc011mjf.1_Splice_Site_p.S260_splice|SH3KBP1_uc004czl.2_Splice_Site_p.S461_splice|SH3KBP1_uc010nfm.2_Splice_Site	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a						apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GAGACACTTACAGATGTGAGG	0.488		NA											5	74					0	0	0	0
SAT1	6303	broad.mit.edu	37	X	23803928	23803928	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:23803928C>A	uc004dau.2	+	6	665	c.471C>A	c.(469-471)TTC>TTA	p.F157L	SAT1_uc004dav.2_RNA	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1	157	N-acetyltransferase.				angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	GGAGACTGTTCAAGATCGACA	0.423		NA											17	15					1.4e-16	1.54e-16	1	0
KDM6A	7403	broad.mit.edu	37	X	44870205	44870205	+	Splice_Site	SNP	G	G	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:44870205G>A	uc004dge.3	+	5	760	c.385_splice	c.e5-1	p.N129_splice	KDM6A_uc010nhk.2_Splice_Site_p.N129_splice|KDM6A_uc011mkz.1_Splice_Site_p.N129_splice|KDM6A_uc011mla.1_Splice_Site_p.N129_splice|KDM6A_uc011mlb.1_Splice_Site_p.N129_splice|KDM6A_uc011mlc.1_Splice_Site	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTCCTTTACAGAATGCTGCCT	0.299		NA	D|N|F|S		renal|oesophageal SCC|MM								5	6					0	0	0	0
MTMR8	55613	broad.mit.edu	37	X	63555987	63555987	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:63555987T>A	uc004dvs.2	-	10	1191	c.1123A>T	c.(1123-1125)ATA>TTA	p.I375L	MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Missense_Mutation_p.I375L	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	375	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CCCATGGATATCCATTCCTTC	0.338		NA											33	10					0	0	0	0
IGSF1	3547	broad.mit.edu	37	X	130412064	130412064	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:130412064C>T	uc004ewd.2	-	13	2324	c.2086G>A	c.(2086-2088)GGC>AGC	p.G696S	IGSF1_uc004ewe.3_Missense_Mutation_p.G690S|IGSF1_uc004ewf.2_Missense_Mutation_p.G676S	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	696	Extracellular (Potential).|Ig-like C2-type 7.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						AGTTCCTGGCCCCGGATTGTG	0.532		NA											37	18					0	0	0	0
ZNF75D	7626	broad.mit.edu	37	X	134426280	134426280	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:134426280C>T	uc004eyp.2	-	4	3186	c.531G>A	c.(529-531)TGG>TGA	p.W177*	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'UTR|ZNF75D_uc004eyo.2_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	177					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTATGTATTCCAATATTCTT	0.498		NA											5	77					0	0	0	0
LDOC1	23641	broad.mit.edu	37	X	140270912	140270912	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:140270912C>T	uc004fbj.2	-	1	399	c.295G>A	c.(295-297)GAA>AAA	p.E99K		NM_012317	NP_036449	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	99					negative regulation of cell proliferation	nucleus	protein binding				0	Acute lymphoblastic leukemia(192;7.65e-05)					TCCTCGGCTTCCCCGGTGAGG	0.552		NA											38	24					0	0	0	0
CXorf40B	541578	broad.mit.edu	37	X	149101932	149101932	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:149101932C>T	uc004fdy.2	-	4	677	c.161G>A	c.(160-162)CGG>CAG	p.R54Q	CXorf40B_uc011mxs.1_RNA	NM_001013845	NP_001013867	Q96DE9	CX04B_HUMAN	hypothetical protein LOC541578	54											0	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAGCTCCCGACAGGCATC	0.587		NA											45	24					0	0	0	0
ITGB1	3688	broad.mit.edu	37	10	33197461	33197462	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:33197461_33197462delCT	uc001iws.3	-	15	2301_2302	c.2165_2166delAG	c.(2164-2166)GAGfs	p.E722fs	ITGB1_uc001iwp.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwq.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwr.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwt.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwu.1_Frame_Shift_Del_p.E722fs	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	722	Extracellular (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CAGTGGGACACTCTGGAAAATA	0.406		NA											18	54	---	---	---	---	NA	NA	NA	NA
AHNAK2	113146	broad.mit.edu	37	14	105413766	105413767	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:105413766_105413767delAG	uc010axc.1	-	7	8141_8142	c.8021_8022delCT	c.(8020-8022)TCTfs	p.S2674fs	AHNAK2_uc001ypx.2_Frame_Shift_Del_p.S2574fs	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2674						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTTCAGCTCAGACACATCCAC	0.564		NA											59	226	---	---	---	---	NA	NA	NA	NA
SLC7A5	8140	broad.mit.edu	37	16	87885358	87885359	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:87885358_87885359insA	uc002fkm.2	-	2	707_708	c.635_636insT	c.(634-636)ATCfs	p.I212fs		NM_003486	NP_003477	Q01650	LAT1_HUMAN	solute carrier family 7 (cationic amino acid	212	Helical; (Potential).				blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding				0				BRCA - Breast invasive adenocarcinoma(80;0.049)		AGCCCAGCAGGATGATCAGGGC	0.668		NA											14	26	---	---	---	---	NA	NA	NA	NA
ZNF750	79755	broad.mit.edu	37	17	80790225	80790226	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:80790225_80790226insA	uc002kga.2	-	2	416_417	c.105_106insT	c.(103-108)AATGAGfs	p.N35fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	35_36						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGTGACTTCTCATTGCAAGTAA	0.411		NA											69	29	---	---	---	---	NA	NA	NA	NA
DNM2	1785	broad.mit.edu	37	19	10893634	10893635	+	Splice_Site	INS	-	-	GGCTACATT			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:10893634_10893635insGGCTACATT	uc002mps.1	+	6	853	c.689_splice	c.e6-1	p.G230_splice	DNM2_uc010dxk.2_Splice_Site|DNM2_uc002mpt.1_Splice_Site_p.G230_splice|DNM2_uc002mpv.1_Splice_Site_p.G230_splice|DNM2_uc002mpu.1_Splice_Site_p.G230_splice|DNM2_uc010dxl.1_Splice_Site_p.G230_splice|DNM2_uc002mpw.2_5'Flank	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2						G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCTCCCCACAGGCTACATTGG	0.574		NA											9	55	---	---	---	---	NA	NA	NA	NA
C19orf2	8725	broad.mit.edu	37	19	30505952	30505952	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:30505952delT	uc002nsr.2	+	11	1614	c.1584delT	c.(1582-1584)GCTfs	p.A528fs	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Frame_Shift_Del_p.A488fs|C19orf2_uc002nst.2_Frame_Shift_Del_p.A452fs	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	528					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		AGTTTAAAGCTGCCAGATTGC	0.413		NA											27	75	---	---	---	---	NA	NA	NA	NA
ARL6IP6	151188	broad.mit.edu	37	2	153575279	153575279	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:153575279delA	uc002tyn.2	+	1	857	c.141delA	c.(139-141)GGAfs	p.G47fs	ARL6IP6_uc002tym.2_Intron|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_5'Flank|PRPF40A_uc010zcd.1_5'Flank|PRPF40A_uc002tyi.2_5'Flank|PRPF40A_uc002tyj.2_5'Flank|PRPF40A_uc002tyl.1_5'Flank	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	47						integral to membrane					0						AGGAGGAGGGATGCGACCAAG	0.706		NA											7	17	---	---	---	---	NA	NA	NA	NA
ZNF334	55713	broad.mit.edu	37	20	45130984	45130985	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:45130984_45130985insA	uc002xsc.2	-	5	1177_1178	c.993_994insT	c.(991-996)TTTCGGfs	p.F331fs	ZNF334_uc002xsa.2_Frame_Shift_Ins_p.F354fs|ZNF334_uc002xsb.2_Frame_Shift_Ins_p.F293fs|ZNF334_uc002xsd.2_Frame_Shift_Ins_p.F293fs|ZNF334_uc010ghl.2_Frame_Shift_Ins_p.F330fs	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	331_332	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GCTGACTTCCGAAAAAAGGTCT	0.436		NA											7	185	---	---	---	---	NA	NA	NA	NA
BMP7	655	broad.mit.edu	37	20	55840910	55840910	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:55840910delA	uc010gip.1	-	1	798	c.269delT	c.(268-270)ATGfs	p.M90fs	BMP7_uc010giq.1_Frame_Shift_Del_p.M90fs|BMP7_uc002xyc.2_Frame_Shift_Del_p.M90fs|uc010gir.1_5'Flank	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	90					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			CTCCACCGCCATGGCGTTGTA	0.672		NA											7	9	---	---	---	---	NA	NA	NA	NA
RINT1	60561	broad.mit.edu	37	7	105190824	105190834	+	Frame_Shift_Del	DEL	TGAAAGGGAGC	TGAAAGGGAGC	-			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:105190824_105190834delTGAAAGGGAGC	uc003vda.1	+	9	1455_1465	c.1224_1234delTGAAAGGGAGC	c.(1222-1236)TTTGAAAGGGAGCTAfs	p.F408fs	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	408_412	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TACTCTTGTTTGAAAGGGAGCTACACAGTGT	0.417		NA											8	183	---	---	---	---	NA	NA	NA	NA