Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CDK11B	984	broad.mit.edu	37	1	1650803	1650803	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:1650803C>G	uc001agv.1	-	6	430	c.319G>C	c.(319-321)GAG>CAG	p.E107Q	CDK11B_uc001ags.1_5'Flank|CDK11B_uc001agt.1_5'Flank|CDK11B_uc001aha.1_Missense_Mutation_p.E73Q|CDK11B_uc001agw.1_Missense_Mutation_p.E73Q|CDK11B_uc001agy.1_Missense_Mutation_p.E107Q|CDK11B_uc001agx.1_Missense_Mutation_p.E107Q|CDK11B_uc001agz.1_5'UTR|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_Missense_Mutation_p.E107Q|CDK11A_uc009vks.2_Missense_Mutation_p.E107Q|CDK11A_uc010nys.1_Missense_Mutation_p.E107Q|CDK11A_uc010nyt.1_Missense_Mutation_p.E107Q|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_Missense_Mutation_p.E107Q|CDK11A_uc009vku.1_Missense_Mutation_p.E107Q|CDK11A_uc009vkv.1_Missense_Mutation_p.E107Q|CDK11A_uc001aht.1_Missense_Mutation_p.E107Q|CDK11B_uc001ahu.1_Missense_Mutation_p.E107Q|CDK11B_uc001ahv.1_Missense_Mutation_p.E107Q|CDK11B_uc001ahw.1_Missense_Mutation_p.E107Q	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	107					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CTACATTTTTCTTTTCTCTTT	0.388		NA											38	127					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103461591	103461591	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:103461591G>A	uc001dul.2	-	27	2567	c.2249C>T	c.(2248-2250)CCT>CTT	p.P750L	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P762L|COL11A1_uc001dun.2_Missense_Mutation_p.P711L|COL11A1_uc009weh.2_Missense_Mutation_p.P634L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	750	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGTGGACCAGGGGGACCCTG	0.358		NA											23	87					0	0	0	0
PMVK	10654	broad.mit.edu	37	1	154897618	154897618	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:154897618C>T	uc001ffq.2	-	5	889	c.566G>A	c.(565-567)CGC>CAC	p.R189H		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	189					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AAGTCTGGAGCGGATAAATTC	0.572		NA											68	116					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181767512	181767512	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:181767512G>A	uc001gow.2	+	47	6520	c.6355G>A	c.(6355-6357)GTC>ATC	p.V2119I	CACNA1E_uc009wxs.2_Missense_Mutation_p.V2007I|CACNA1E_uc009wxt.2_Missense_Mutation_p.V1388I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2162	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCTCCCACCCGTCCCGCCAAA	0.627		NA											43	94					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198711143	198711143	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:198711143T>C	uc001gur.1	+	24	2723	c.2543T>C	c.(2542-2544)GTG>GCG	p.V848A	PTPRC_uc001gus.1_Missense_Mutation_p.V800A|PTPRC_uc001gut.1_Missense_Mutation_p.V687A	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	848	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GGTCCCATTGTGGTGCACTGC	0.473		NA											5	22					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16942822	16942822	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr10:16942822G>A	uc001ioo.2	-	53	8264	c.8212C>T	c.(8212-8214)CCC>TCC	p.P2738S	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.P94S	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2738	CUB 20.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTGTATGGGGTTCAATATCA	0.433		NA											3	29					0	0	0	0
POLR2L	5441	broad.mit.edu	37	11	840466	840466	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr11:840466G>T	uc001lsc.2	-	2	131	c.110C>A	c.(109-111)GCC>GAC	p.A37D	TSPAN4_uc001lsd.1_5'Flank|TSPAN4_uc001lse.1_5'Flank|TSPAN4_uc001lsf.1_5'Flank|TSPAN4_uc001lsg.1_5'Flank|TSPAN4_uc001lsh.1_5'Flank	NM_021128	NP_066951	P62875	RPAB5_HUMAN	DNA directed RNA polymerase II polypeptide L	37					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;4.1e-25)|Epithelial(43;3.15e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGGCCCAGGGCATCCAGCGC	0.622		NA											41	75					7.53e-24	8.83e-24	1	0
FAM90A1	55138	broad.mit.edu	37	12	8375146	8375146	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr12:8375146G>C	uc001qui.2	-	7	1226	c.667C>G	c.(667-669)CTC>GTC	p.L223V	FAM90A1_uc001quh.2_Missense_Mutation_p.L223V	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	223							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		ACCACGAGGAGAGGCTCGGGG	0.647		NA											33	57					0	0	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57988994	57988994	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr12:57988994C>T	uc001sou.2	+	3	489	c.358C>T	c.(358-360)CAA>TAA	p.Q120*	PIP4K2C_uc001sot.2_Nonsense_Mutation_p.Q120*|PIP4K2C_uc010srs.1_Nonsense_Mutation_p.Q102*|PIP4K2C_uc010srt.1_Nonsense_Mutation_p.Q120*	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	120	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					CATTGATGACCAAGATTACTT	0.463		NA											130	147					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23906082	23906082	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr13:23906082A>C	uc001uon.2	-	10	12522	c.11933T>G	c.(11932-11934)CTT>CGT	p.L3978R	SACS_uc001uoo.2_Missense_Mutation_p.L3831R|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3978					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTGTTCTTCAAGTATACTGCT	0.398		NA											23	79					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23445688	23445688	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr14:23445688A>T	uc001whz.2	-	4	1592	c.1216T>A	c.(1216-1218)TGT>AGT	p.C406S	JUB_uc001why.2_5'UTR	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	406	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AAGTGACCACAGACACAGCAT	0.453		NA											114	60					0	0	0	0
ACOT1	641371	broad.mit.edu	37	14	74004392	74004392	+	Silent	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr14:74004392C>T	uc001xol.1	+	1	465	c.267C>T	c.(265-267)CCC>CCT	p.P89P	HEATR4_uc010tua.1_Intron|ACOT1_uc010tuc.1_Silent_p.P89P	NM_001037161	NP_001032238	Q86TX2	ACOT1_HUMAN	acyl-CoA thioesterase 1	89					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	cytosol	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(108;1.37e-45)|BRCA - Breast invasive adenocarcinoma(234;0.0033)		CCGAGAAACCCTTGGTGCGGC	0.736		NA											4	16					0	0	0	0
CDAN1	146059	broad.mit.edu	37	15	43023151	43023151	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr15:43023151T>C	uc001zql.2	-	13	2096	c.1979A>G	c.(1978-1980)CAG>CGG	p.Q660R	CDAN1_uc001zqj.2_5'Flank|CDAN1_uc001zqk.2_5'UTR	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	660						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		AATGGAGTCCTGAAGCTCACC	0.607		NA											4	132					0	0	0	0
ISL2	64843	broad.mit.edu	37	15	76633517	76633517	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr15:76633517C>G	uc002bbw.1	+	5	916	c.838C>G	c.(838-840)CCC>GCC	p.P280A		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	280						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCGGGCAGTCCCATCCGCCA	0.657		NA											15	29					0	0	0	0
SEPX1	51734	broad.mit.edu	37	16	1991308	1991308	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr16:1991308C>T	uc010uvs.1	-	2	291	c.154G>A	c.(154-156)GCC>ACC	p.A52T		NM_016332	NP_057416	Q9NZV6	MSRB1_HUMAN	selenoprotein X, 1	52					protein repair	cytoplasm|nucleus	peptide-methionine-(S)-S-oxide reductase activity|zinc ion binding			ovary(1)	1					L-Methionine(DB00134)	ACGCTGTCGGCGTGAATGGTC	0.622		NA											7	50					0	0	0	0
CYLD	1540	broad.mit.edu	37	16	50816274	50816274	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr16:50816274A>T	uc002egp.1	+	11	2138	c.1723A>T	c.(1723-1725)ACT>TCT	p.T575S	CYLD_uc002ego.2_Missense_Mutation_p.T572S|CYLD_uc010cbs.1_Missense_Mutation_p.T572S|CYLD_uc002egq.1_Missense_Mutation_p.T572S|CYLD_uc002egr.1_Missense_Mutation_p.T572S|CYLD_uc002egs.1_Missense_Mutation_p.T572S	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	575	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AGAAGAAAATACTCCACCAAA	0.303		NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				12	21					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578550	7578550	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr17:7578550G>T	uc002gim.2	-	5	574	c.380C>A	c.(379-381)TCC>TAC	p.S127Y	TP53_uc002gig.1_Missense_Mutation_p.S127Y|TP53_uc002gih.2_Missense_Mutation_p.S127Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.S127Y|TP53_uc010cni.1_Missense_Mutation_p.S127Y|TP53_uc002gij.2_Missense_Mutation_p.S127Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S34Y|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.S88Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	127	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S127F(18)|p.S127Y(8)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.Y126_N131delYSPALN(3)|p.S127P(3)|p.S127T(2)|p.P128fs*42(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.P128fs*18(1)|p.Y126fs*11(1)|p.S127S(1)|p.S127C(1)|p.S127_Q136del10(1)|p.P13fs*18(1)|p.?(1)|p.S127fs*43(1)|p.S127fs*42(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGGCAGGGGAGTACTGTAG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	29					1.02e-10	1.16e-10	1	0
ARMC6	93436	broad.mit.edu	37	19	19162842	19162842	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr19:19162842C>T	uc002nld.2	+	5	1039	c.691C>T	c.(691-693)CAT>TAT	p.H231Y	ARMC6_uc002nlc.2_Missense_Mutation_p.H206Y|ARMC6_uc010xql.1_Missense_Mutation_p.H138Y|ARMC6_uc002nle.2_Missense_Mutation_p.H206Y|ARMC6_uc010xqm.1_Missense_Mutation_p.H231Y	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	231	ARM 1.						protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			TGCCATCACCCATCATGGCCA	0.592		NA											7	44					0	0	0	0
RYR1	6261	broad.mit.edu	37	19	38991629	38991629	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr19:38991629C>T	uc002oit.2	+	47	7743	c.7613C>T	c.(7612-7614)ACG>ATG	p.T2538M	RYR1_uc002oiu.2_Missense_Mutation_p.T2538M|RYR1_uc002oiv.1_Translation_Start_Site	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2538	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCGCTGGACACGGTGAGCAAC	0.612		NA											8	14					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33623487	33623487	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:33623487T>C	uc002ros.2	+	34	5044	c.5044T>C	c.(5044-5046)TGC>CGC	p.C1682R	LTBP1_uc002rot.2_Missense_Mutation_p.C1356R|LTBP1_uc002rou.2_Missense_Mutation_p.C1355R|LTBP1_uc002rov.2_Missense_Mutation_p.C1302R|LTBP1_uc010ymz.1_Missense_Mutation_p.C1313R|LTBP1_uc010yna.1_Missense_Mutation_p.C1260R|LTBP1_uc010ynb.1_Missense_Mutation_p.C579R	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1681	EGF-like 18; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GAATGCCAAGTGCATTAACAC	0.438		NA											40	50					0	0	0	0
CYP27C1	339761	broad.mit.edu	37	2	127958736	127958736	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:127958736C>T	uc002tod.2	-	3	481	c.350G>A	c.(349-351)CGG>CAG	p.R117Q		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	117						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		GCAGAATTCCCGCCAGGGCTT	0.522		NA											64	118					0	0	0	0
CPS1	1373	broad.mit.edu	37	2	211441130	211441130	+	Silent	SNP	T	T	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:211441130T>C	uc002vee.3	+	3	429	c.297T>C	c.(295-297)CCT>CCC	p.P99P	CPS1_uc010fur.2_Silent_p.P105P	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	99	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGCCAACCCTATTATTGGGA	0.428		NA											3	117					0	0	0	0
PREX1	57580	broad.mit.edu	37	20	47244457	47244457	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr20:47244457C>T	uc002xtw.1	-	38	4834	c.4811G>A	c.(4810-4812)CGG>CAG	p.R1604Q	PREX1_uc002xtv.1_Missense_Mutation_p.R901Q	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1604					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCCGTGGCTCCGTGCCAAGAT	0.692		NA											11	30					0	0	0	0
NKTR	4820	broad.mit.edu	37	3	42676726	42676726	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:42676726C>G	uc003clo.2	+	12	1178	c.1031C>G	c.(1030-1032)CCT>CGT	p.P344R	NKTR_uc003clm.1_Missense_Mutation_p.P91R|NKTR_uc003clp.2_Missense_Mutation_p.P91R|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.P234R|NKTR_uc003clr.1_Missense_Mutation_p.P91R|NKTR_uc003cls.2_Missense_Mutation_p.P44R	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	344					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TATCACACACCTCCAAGATCA	0.398		NA											31	9					0	0	0	0
NKTR	4820	broad.mit.edu	37	3	42680280	42680280	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:42680280G>T	uc003clo.2	+	13	3231	c.3084G>T	c.(3082-3084)GAG>GAT	p.E1028D	NKTR_uc003clm.1_Missense_Mutation_p.E775D|NKTR_uc003clp.2_Missense_Mutation_p.E775D|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.E918D|NKTR_uc003clr.1_Missense_Mutation_p.E775D|NKTR_uc003cls.2_Missense_Mutation_p.E728D	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1028					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AGGAGGAGGAGGAGATTGATG	0.358		NA											48	22					2.75e-27	3.24e-27	1	0
BOC	91653	broad.mit.edu	37	3	112993314	112993314	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:112993314A>G	uc003dzx.2	+	9	1948	c.1327A>G	c.(1327-1329)AGG>GGG	p.R443G	BOC_uc003dzy.2_Missense_Mutation_p.R443G|BOC_uc003dzz.2_Missense_Mutation_p.R443G|BOC_uc003eab.2_Missense_Mutation_p.R144G	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	443	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GCAGATGCTGAGGGGGCAACC	0.652		NA											36	36					0	0	0	0
PLK4	10733	broad.mit.edu	37	4	128812740	128812740	+	Missense_Mutation	SNP	A	A	G	rs11552117		TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr4:128812740A>G	uc003ifo.2	+	9	2187	c.1942A>G	c.(1942-1944)ATT>GTT	p.I648V	PLK4_uc011cgs.1_Missense_Mutation_p.I616V|PLK4_uc011cgt.1_Missense_Mutation_p.I607V	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	648					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GCAGATCACTATTTATTATCC	0.338		NA											53	97					0	0	0	0
AFF4	27125	broad.mit.edu	37	5	132269985	132269985	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr5:132269985G>A	uc003kyd.2	-	3	1180	c.772C>T	c.(772-774)CGG>TGG	p.R258W	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.R258W|AFF4_uc003kyf.3_Missense_Mutation_p.R258W	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	258	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCATGGGCCGCACATAGGCA	0.517		NA											4	95					0	0	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559714	140559714	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr5:140559714C>T	uc011dai.1	+	1	2285	c.2099C>T	c.(2098-2100)TCG>TTG	p.S700L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	700	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTGTCTTCGCTCTTCCTC	0.672		NA											134	38					0	0	0	0
NT5E	4907	broad.mit.edu	37	6	86197162	86197162	+	Silent	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr6:86197162C>T	uc003pko.3	+	5	1615	c.1059C>T	c.(1057-1059)TGC>TGT	p.C353C	NT5E_uc010kbr.2_Silent_p.C353C	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	353					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	CTCAATCATGCCGCTTTAGAG	0.348		NA											5	185					0	0	0	0
SP8	221833	broad.mit.edu	37	7	20825289	20825289	+	Silent	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr7:20825289G>A	uc003suy.2	-	3	334	c.93C>T	c.(91-93)CAC>CAT	p.H31H	SP8_uc003suz.2_Silent_p.H49H	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	31	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GTTTCCAGGGGTGGAAGCCTT	0.617		NA											21	42					0	0	0	0
ABCB4	5244	broad.mit.edu	37	7	87051469	87051469	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr7:87051469C>T	uc003uiv.1	-	18	2360	c.2284G>A	c.(2284-2286)GGA>AGA	p.G762R	ABCB4_uc003uiw.1_Missense_Mutation_p.G762R|ABCB4_uc003uix.1_Missense_Mutation_p.G762R	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	762	Helical; (By similarity).|ABC transmembrane type-1 2.		G -> E (in ICP).		cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GAAATAATTCCCAGAAATAAG	0.318		NA											3	15					0	0	0	0
ZNF282	8427	broad.mit.edu	37	7	148909533	148909533	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr7:148909533G>A	uc003wfm.2	+	6	1141	c.1036G>A	c.(1036-1038)GAC>AAC	p.D346N	ZNF282_uc011kun.1_Missense_Mutation_p.D346N|ZNF282_uc003wfn.2_Missense_Mutation_p.D286N|ZNF282_uc003wfo.2_Intron	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	346					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GGATTTGGCAGACAGAGATAT	0.353		NA											3	31					0	0	0	0
DPY19L4	286148	broad.mit.edu	37	8	95802031	95802031	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr8:95802031G>A	uc003ygx.2	+	19	2189	c.2065G>A	c.(2065-2067)GAG>AAG	p.E689K		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	689						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					ATTTTGTCATGAGGTCAAAAT	0.303		NA											98	188					0	0	0	0
SECISBP2	79048	broad.mit.edu	37	9	91972404	91972404	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:91972404G>A	uc004aqj.1	+	15	2272	c.2192G>A	c.(2191-2193)CGC>CAC	p.R731H	SECISBP2_uc011ltk.1_Missense_Mutation_p.R730H|SECISBP2_uc004aqk.1_Missense_Mutation_p.R658H|SECISBP2_uc010mqo.1_Missense_Mutation_p.R436H|SECISBP2_uc011ltl.1_Missense_Mutation_p.R663H	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	731					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						GCTCTCAACCGCAAAGCTCTG	0.507		NA											6	205					0	0	0	0
ROR2	4920	broad.mit.edu	37	9	94519560	94519560	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:94519560G>A	uc004arj.1	-	3	656	c.457C>T	c.(457-459)CGG>TGG	p.R153W	ROR2_uc004ari.1_Missense_Mutation_p.R13W|ROR2_uc004ark.2_Missense_Mutation_p.R153W	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	153	Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						TCACCCAGCCGCACAAACAGG	0.537		NA											4	123					0	0	0	0
SUSD1	64420	broad.mit.edu	37	9	114886703	114886703	+	Silent	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:114886703G>A	uc004bfu.2	-	6	761	c.720C>T	c.(718-720)GGC>GGT	p.G240G	SUSD1_uc010mui.2_Silent_p.G240G|SUSD1_uc010muj.2_Silent_p.G240G	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	240	Sushi 2.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						CTGGAGGGTTGCCACAGTTGA	0.483		NA											76	39					0	0	0	0
OR1N1	138883	broad.mit.edu	37	9	125288894	125288894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:125288894G>A	uc004bmn.1	-	1	679	c.679C>T	c.(679-681)CGA>TGA	p.R227*		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						CCACGGGTTCGGACCCTCAGG	0.542		NA											44	31					0	0	0	0
SNAPC4	6621	broad.mit.edu	37	9	139273678	139273678	+	Silent	SNP	C	C	A			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:139273678C>A	uc004chh.2	-	21	2610	c.2601G>T	c.(2599-2601)GCG>GCT	p.A867A		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	867					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CCCGGCTGGACGCCAGTCTTC	0.642		NA											6	30					8.13e-05	8.96e-05	1	0
FAM123B	139285	broad.mit.edu	37	X	63412939	63412939	+	Silent	SNP	T	T	C			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chrX:63412939T>C	uc004dvo.2	-	2	501	c.228A>G	c.(226-228)GGA>GGG	p.G76G		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	76					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTTTGCTCCGTCCCCCTCCAA	0.537		NA											3	74					0	0	0	0
RLTPR	146206	broad.mit.edu	37	16	67680147	67680148	+	In_Frame_Ins	INS	-	-	CCTGGA			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr16:67680147_67680148insCCTGGA	uc002etn.2	+	5	428_429	c.308_309insCCTGGA	c.(307-309)GCC>GCCCTGGAC	p.103_104insLD	RLTPR_uc010cel.1_In_Frame_Ins_p.103_104insLD|RLTPR_uc010vjr.1_In_Frame_Ins_p.103_104insLD	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	103_104	LRR 2.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGTGTGGCCGCCCTGGAACAGC	0.639		NA											15	61	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7577594	7577595	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr17:7577594_7577595delAC	uc002gim.2	-	7	880_881	c.686_687delGT	c.(685-687)TGTfs	p.C229fs	TP53_uc002gig.1_Frame_Shift_Del_p.C229fs|TP53_uc002gih.2_Frame_Shift_Del_p.C229fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.C97fs|TP53_uc010cng.1_Frame_Shift_Del_p.C97fs|TP53_uc002gii.1_Frame_Shift_Del_p.C97fs|TP53_uc010cnh.1_Frame_Shift_Del_p.C229fs|TP53_uc010cni.1_Frame_Shift_Del_p.C229fs|TP53_uc002gij.2_Frame_Shift_Del_p.C229fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.C136fs|TP53_uc002gio.2_Frame_Shift_Del_p.C97fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	229	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> Y (in sporadic cancers; somatic mutation).|C -> G (in a sporadic cancer; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C229fs*10(10)|p.0?(7)|p.C229*(3)|p.C229S(2)|p.C229R(2)|p.C229Y(2)|p.C229_H233delCTTIH(2)|p.T230fs*9(1)|p.C229fs*1(1)|p.C229fs*18(1)|p.C229_T230insX(1)|p.C229C(1)|p.V225fs*23(1)|p.D228fs*12(1)|p.C229G(1)|p.C229_I232del(1)|p.S227_I232delSDCTTI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGATGGTGGTACAGTCAGAGCC	0.525		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	71	---	---	---	---	NA	NA	NA	NA
SSB	6741	broad.mit.edu	37	2	170665008	170665008	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:170665008delA	uc002ufk.2	+	7	678	c.571delA	c.(571-573)AAAfs	p.K191fs	SSB_uc002ufl.2_Frame_Shift_Del_p.K191fs|SSB_uc002ufm.2_Frame_Shift_Del_p.K191fs	NM_003142	NP_003133	P05455	LA_HUMAN	autoantigen La	191					histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			skin(3)|pancreas(1)	4						TTACTTTGCCAAAAAAAATGA	0.323		NA											7	118	---	---	---	---	NA	NA	NA	NA
C22orf43	51233	broad.mit.edu	37	22	23959767	23959769	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr22:23959767_23959769delCAT	uc002zxf.2	-	7	789_791	c.512_514delATG	c.(511-516)GATGCC>GCC	p.D171del		NM_016449	NP_057533	Q6PGQ1	CV043_HUMAN	hypothetical protein LOC51233	171	Asp-rich.									skin(1)	1						CTTACCTGGGcatcatcatcatc	0.261		NA											10	341	---	---	---	---	NA	NA	NA	NA
DNAJB11	51726	broad.mit.edu	37	3	186295532	186295534	+	In_Frame_Del	DEL	TAT	TAT	-			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:186295532_186295534delTAT	uc003fqi.2	+	4	619_621	c.399_401delTAT	c.(397-402)GATATT>GAT	p.I135del		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	135					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		GAGGAAGTGATATTATTGTAGAT	0.369		NA											20	64	---	---	---	---	NA	NA	NA	NA
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	-	G			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr8:110455173_110455174insG	uc003yne.2	+	36	4498	c.4394_splice	c.e36-1	p.G1465_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322		NA								HNSCC(38;0.096)			9	193	---	---	---	---	NA	NA	NA	NA