Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SPEN	23013	broad.mit.edu	37	1	16260533	16260533	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:16260533G>A	uc001axk.1	+	11	8002	c.7798G>A	c.(7798-7800)GAG>AAG	p.E2600K	SPEN_uc010obp.1_Missense_Mutation_p.E2559K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2600	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACAAGCCTCGGAGGTGCTGGT	0.498		NA											12	113					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109806318	109806318	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:109806318C>T	uc001dxa.3	+	9	4981	c.4920C>T	c.(4918-4920)CTC>CTT	p.L1640L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1640	Extracellular (Potential).|Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCTGGTACCTCAGCCTCATGT	0.652		NA									OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	120					0	0	0	0
GPR89A	653519	broad.mit.edu	37	1	145765384	145765384	+	Silent	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:145765384T>C	uc001eot.2	-	13	1320	c.1146A>G	c.(1144-1146)CTA>CTG	p.L382L	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Silent_p.L80L|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Silent_p.L306L|GPR89A_uc010ozb.1_Silent_p.L357L|GPR89A_uc001eos.2_Silent_p.L262L|GPR89A_uc010ozc.1_Silent_p.L357L|GPR89A_uc010ozd.1_Silent_p.L329L|GPR89A_uc010oze.1_Silent_p.L382L	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	382	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TCTGTGCTAATAGCAGGACAA	0.328		NA											23	173					0	0	0	0
LHX9	56956	broad.mit.edu	37	1	197887087	197887087	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:197887087C>T	uc001guk.1	+	1	571	c.134C>T	c.(133-135)GCC>GTC	p.A45V	LHX9_uc009wzc.1_RNA|LHX9_uc001gui.1_Missense_Mutation_p.A36V|LHX9_uc001guj.1_Missense_Mutation_p.A51V	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	45					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						AAGACTGAGGCCCGTCTGGCC	0.657		NA											7	79					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198668699	198668699	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:198668699C>T	uc001gur.1	+	5	479	c.299C>T	c.(298-300)TCA>TTA	p.S100L	PTPRC_uc001gus.1_Missense_Mutation_p.S100L|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.S36L|PTPRC_uc009wzf.1_Missense_Mutation_p.S36L|PTPRC_uc010ppg.1_Missense_Mutation_p.S36L|PTPRC_uc001guu.1_Missense_Mutation_p.S143L|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	100	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTAGGTGTTTCATCAGTACAG	0.488		NA									OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	72					0	0	0	0
KIF14	9928	broad.mit.edu	37	1	200587425	200587425	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:200587425T>C	uc010ppk.1	-	2	866	c.427A>G	c.(427-429)ATG>GTG	p.M143V	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	143	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCAGTGTCATTTTGACAGAA	0.348		NA											5	58					0	0	0	0
TTC13	79573	broad.mit.edu	37	1	231061288	231061288	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:231061288G>A	uc001huf.3	-	13	1594	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	TTC13_uc009xfi.2_Silent_p.F468F|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Silent_p.F468F|TTC13_uc009xfk.1_Silent_p.F411F	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	521							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TGTTTGGCAGGAAACCAGGTG	0.408		NA											6	62					0	0	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249108682	249108682	+	Missense_Mutation	SNP	G	G	A	rs151290329		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:249108682G>A	uc001iew.1	-	5	1055	c.503C>T	c.(502-504)ACG>ATG	p.T168M	SH3BP5L_uc010pzp.1_Missense_Mutation_p.T61M|SH3BP5L_uc010pzq.1_Missense_Mutation_p.T136M|SH3BP5L_uc001iev.1_Missense_Mutation_p.T49M	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	168											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CTCCTGCCACGTGGGGTCCAG	0.592		NA											3	41					0	0	0	0
DNMBP	23268	broad.mit.edu	37	10	101657950	101657950	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr10:101657950T>A	uc001kqj.2	-	9	2905	c.2813A>T	c.(2812-2814)AAT>ATT	p.N938I	DNMBP_uc010qpl.1_5'UTR|DNMBP_uc001kqg.2_Missense_Mutation_p.N226I|DNMBP_uc001kqh.2_Missense_Mutation_p.N570I	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	938	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGGGGTGGAATTCAGCAACTC	0.438		NA											11	73					0	0	0	0
TTC17	55761	broad.mit.edu	37	11	43513699	43513699	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:43513699G>T	uc001mxi.2	+	23	3294	c.3280G>T	c.(3280-3282)GTC>TTC	p.V1094F	TTC17_uc010rfj.1_Missense_Mutation_p.V1094F|TTC17_uc001mxl.2_Missense_Mutation_p.V150F|TTC17_uc001mxm.2_Missense_Mutation_p.V75F	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1094	TPR 6.						binding			ovary(5)	5						TCTGGGCAATGTCTACGTGGC	0.478		NA											9	86					1.13e-05	1.22e-05	1	0
OR5B12	390191	broad.mit.edu	37	11	58207492	58207492	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:58207492C>G	uc010rkh.1	-	1	133	c.133G>C	c.(133-135)GAA>CAA	p.E45Q		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	45	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGAATCAATTCAATCATCCCC	0.488		NA											5	49					0	0	0	0
SNX15	29907	broad.mit.edu	37	11	64802351	64802351	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:64802351C>T	uc001oci.3	+	7	942	c.289C>T	c.(289-291)CGA>TGA	p.R97*	SNX15_uc009ypy.2_Nonsense_Mutation_p.R97*|SNX15_uc001ocj.2_Nonsense_Mutation_p.R97*|SNX15_uc001ock.2_Nonsense_Mutation_p.R97*	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	97	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						CGAGGAGCGGCGAAAGGGGGC	0.622		NA											4	48					0	0	0	0
MMP7	4316	broad.mit.edu	37	11	102401427	102401427	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:102401427C>T	uc001phb.2	-	1	52	c.5G>A	c.(4-6)CGA>CAA	p.R2Q	MMP7_uc009yxd.2_Missense_Mutation_p.R2Q|MMP7_uc010rus.1_Missense_Mutation_p.R2Q	NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	2					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		CACGGTGAGTCGCATAGCTGC	0.547		NA											5	50					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335745	117335745	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:117335745C>T	uc001prh.1	-	17	3360	c.3358G>A	c.(3358-3360)GCC>ACC	p.A1120T		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1060	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCATACTGGGCGAACTTCTTG	0.622		NA											6	92					0	0	0	0
AMIGO2	347902	broad.mit.edu	37	12	47472579	47472579	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:47472579C>T	uc001rpm.2	-	3	862	c.207G>A	c.(205-207)CTG>CTA	p.L69L	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Silent_p.L69L|AMIGO2_uc001rpl.2_Silent_p.L69L	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	69	Extracellular (Potential).|LRR 1.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					GTCTCTTAATCAGTCTGAAAA	0.493		NA											7	66					0	0	0	0
VDR	7421	broad.mit.edu	37	12	48238570	48238570	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:48238570T>C	uc001rqm.2	-	11	1525	c.1243A>G	c.(1243-1245)ACG>GCG	p.T415A	VDR_uc001rql.2_Missense_Mutation_p.T465A|VDR_uc001rqn.2_Missense_Mutation_p.T415A|VDR_uc010slq.1_Missense_Mutation_p.T383A	NM_001017535	NP_001017535	P11473	VDR_HUMAN	vitamin D (1,25-dihydroxyvitamin D3) receptor	415	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ACAAGGGGCGTTAGCTTCATG	0.607		NA											4	31					0	0	0	0
TENC1	23371	broad.mit.edu	37	12	53455639	53455639	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:53455639G>A	uc001sbp.2	+	22	3624	c.3489G>A	c.(3487-3489)CTG>CTA	p.L1163L	TENC1_uc001sbl.2_Silent_p.L1039L|TENC1_uc001sbn.2_Silent_p.L1173L|TENC1_uc001sbq.2_Silent_p.L561L|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Silent_p.L658L|TENC1_uc001sbs.2_5'UTR	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1163	SH2.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						GGGCCTTCCTGATCAGGGACA	0.617		NA											12	139					0	0	0	0
RARG	5916	broad.mit.edu	37	12	53609131	53609131	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:53609131G>A	uc001sce.2	-	5	906	c.421C>T	c.(421-423)CGC>TGC	p.R141C	RARG_uc001scd.2_Missense_Mutation_p.R130C|RARG_uc010sob.1_Missense_Mutation_p.R119C|RARG_uc001scf.2_Missense_Mutation_p.R141C|RARG_uc001scg.2_Missense_Mutation_p.R69C|RARG_uc010soc.1_Missense_Mutation_p.R20C|RARG_uc010sod.1_Missense_Mutation_p.R178C	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	141	NR C4-type.|Nuclear receptor.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TACTGGCAGCGATTCCTGGTC	0.552		NA											8	85					0	0	0	0
IFT81	28981	broad.mit.edu	37	12	110574583	110574583	+	Silent	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:110574583A>G	uc001tqi.2	+	8	829	c.699A>G	c.(697-699)CTA>CTG	p.L233L	IFT81_uc001tqh.2_Silent_p.L233L|IFT81_uc001tqj.2_RNA|IFT81_uc001tqg.2_Silent_p.L233L	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	233	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						TTTTAAAGCTATTTCATGCAG	0.348		NA											3	21					0	0	0	0
AKAP6	9472	broad.mit.edu	37	14	33292535	33292535	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:33292535C>G	uc001wrq.2	+	13	5686	c.5516C>G	c.(5515-5517)CCC>CGC	p.P1839R		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1839			P -> T (in a colorectal cancer sample; somatic mutation).		protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding	p.P1839T(1)		breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATGACCAATCCCTCTGATACT	0.373		NA											4	75					0	0	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633915	70633915	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:70633915C>G	uc001xly.2	-	2	1979	c.1225G>C	c.(1225-1227)GAG>CAG	p.E409Q	SLC8A3_uc001xlw.2_Missense_Mutation_p.E409Q|SLC8A3_uc001xlx.2_Missense_Mutation_p.E409Q|SLC8A3_uc001xlz.2_Missense_Mutation_p.E409Q|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	409	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CCACAGTTCTCCAGGCACTGG	0.512		NA											15	106					0	0	0	0
YY1	7528	broad.mit.edu	37	14	100728656	100728656	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:100728656T>C	uc001ygy.1	+	2	1175	c.695T>C	c.(694-696)ATT>ACT	p.I232T		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	232					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				AAAAAAGATATTGACCATGAG	0.333		NA											4	47					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	26026297	26026297	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:26026297C>T	uc010ayu.2	-	2	629	c.523G>A	c.(523-525)GAA>AAA	p.E175K		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	175	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGGAAGATTTCGTTGCAGCGA	0.493		NA											3	33					0	0	0	0
TLN2	83660	broad.mit.edu	37	15	62942335	62942335	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:62942335G>A	uc002alb.3	+	2	189	c.189G>A	c.(187-189)TGG>TGA	p.W63*		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	63					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AAGGGATTTGGCTGGAAGCGG	0.478		NA											7	87					0	0	0	0
TRAP1	10131	broad.mit.edu	37	16	3736066	3736066	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:3736066G>A	uc002cvt.3	-	4	491	c.402C>T	c.(400-402)GAC>GAT	p.D134D	TRAP1_uc010uxf.1_Silent_p.D81D	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	134					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				GTGCTTGGCCGTCAGACACCA	0.532		NA											4	58					0	0	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25255343	25255343	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:25255343G>C	uc002dod.3	-	6	2151	c.1744C>G	c.(1744-1746)CTG>GTG	p.L582V	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.L378V	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	582					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GAGTTAATCAGGGCATCCATC	0.532		NA											7	59					0	0	0	0
ZNF668	79759	broad.mit.edu	37	16	31075507	31075507	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:31075507C>G	uc010caf.2	-	2	631	c.274G>C	c.(274-276)GCC>CCC	p.A92P	ZNF668_uc002eao.2_Missense_Mutation_p.A92P|ZNF668_uc010cag.1_Missense_Mutation_p.A92P	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	92	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GTCTTGTAGGCCTTGGGGCAT	0.667		NA											5	38					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10209914	10209914	+	Silent	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:10209914T>C	uc002gmk.1	-	37	5418	c.5328A>G	c.(5326-5328)GAA>GAG	p.E1776E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1776	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGTGTCCTGTTCCTTCTTTA	0.577		NA											9	96					0	0	0	0
FAM83G	644815	broad.mit.edu	37	17	18882983	18882983	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:18882983G>T	uc002guw.2	-	4	861	c.694C>A	c.(694-696)CTC>ATC	p.L232I	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	232										ovary(1)|central_nervous_system(1)	2						CGCACTCTGAGATTCTGTTTT	0.587		NA											6	89					0.00448238	0.00475938	1	0
VAV1	7409	broad.mit.edu	37	19	6829898	6829898	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:6829898A>T	uc002mfu.1	+	14	1464	c.1367A>T	c.(1366-1368)GAT>GTT	p.D456V	VAV1_uc010xjh.1_Missense_Mutation_p.D424V|VAV1_uc010dva.1_Missense_Mutation_p.D456V|VAV1_uc002mfv.1_Missense_Mutation_p.D401V	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	456	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CAGGTTCGGGATGACTCTTCA	0.552		NA											4	61					0	0	0	0
KEAP1	9817	broad.mit.edu	37	19	10597384	10597384	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:10597384C>G	uc002moq.1	-	6	1975	c.1819G>C	c.(1819-1821)GCT>CCT	p.A607P	KEAP1_uc002mop.1_Missense_Mutation_p.A266P|KEAP1_uc002mor.1_Missense_Mutation_p.A607P	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	607	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATGGTGACAGCCACGCCCACC	0.557		NA											8	122					0	0	0	0
ZNF563	147837	broad.mit.edu	37	19	12429679	12429679	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:12429679T>A	uc002mtp.2	-	4	1398	c.1160A>T	c.(1159-1161)CAC>CTC	p.H387L		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	387	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCTCCAGTGTGCATTATCAT	0.418		NA											13	144					0	0	0	0
GADD45GIP1	90480	broad.mit.edu	37	19	13065144	13065144	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:13065144C>T	uc002mwb.2	-	2	571	c.547G>A	c.(547-549)GAG>AAG	p.E183K		NM_052850	NP_443082	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma	183	Potential.				cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(1)|skin(1)	2						TCCTTCTTCTCTAGGTCCTGG	0.627		NA											6	101					0	0	0	0
CYTH2	9266	broad.mit.edu	37	19	48981788	48981788	+	Missense_Mutation	SNP	A	A	G	rs144064799		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:48981788A>G	uc002pjj.3	+	12	1354	c.1054A>G	c.(1054-1056)ATG>GTG	p.M352V	CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	352	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GGGAAACCACATGGTGTACCG	0.463		NA											3	54					0	0	0	0
NUP62	23636	broad.mit.edu	37	19	50412820	50412820	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:50412820G>A	uc002pqx.2	-	2	349	c.245C>T	c.(244-246)GCT>GTT	p.A82V	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.A82V|NUP62_uc002pqz.2_Missense_Mutation_p.A82V|NUP62_uc002pra.2_Missense_Mutation_p.A82V|NUP62_uc002prb.2_Missense_Mutation_p.A82V|NUP62_uc002prc.2_Missense_Mutation_p.A82V	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	82	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCCCCCGAAGCAAGAGTCGC	0.577		NA											14	131					0	0	0	0
KLF11	8462	broad.mit.edu	37	2	10186310	10186310	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:10186310G>A	uc002raf.1	+	2	238	c.76G>A	c.(76-78)GAG>AAG	p.E26K	KLF11_uc010yjc.1_Missense_Mutation_p.E9K	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	26					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GTCCATCCTGGAGAGGAAGCG	0.522		NA											5	50					0	0	0	0
PSD4	23550	broad.mit.edu	37	2	113950906	113950906	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:113950906G>T	uc002tjc.2	+	8	2174	c.1991G>T	c.(1990-1992)AGA>ATA	p.R664I	PSD4_uc002tjd.2_Missense_Mutation_p.R285I|PSD4_uc002tje.2_Missense_Mutation_p.R635I|PSD4_uc002tjf.2_Missense_Mutation_p.R285I	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	664	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CAGTTCTCCAGACGCTTCCAC	0.597		NA											4	62					0.00024832	0.000265155	1	0
BMPR2	659	broad.mit.edu	37	2	203420620	203420620	+	Silent	SNP	T	T	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:203420620T>G	uc002uzf.3	+	12	3380	c.2232T>G	c.(2230-2232)CCT>CCG	p.P744P	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	744	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AGATCTATCCTCTCCCCAAGC	0.458		NA											5	72					0	0	0	0
MAFB	9935	broad.mit.edu	37	20	39317186	39317186	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr20:39317186A>G	uc002xji.2	-	1	691	c.305T>C	c.(304-306)CTG>CCG	p.L102P		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	102					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CTCGGGCGTCAGGTTGAGCGC	0.587		NA	T	IGH@	MM								3	62					0	0	0	0
APCDD1L	164284	broad.mit.edu	37	20	57035940	57035940	+	Missense_Mutation	SNP	G	G	A	rs147052922	byFrequency	TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr20:57035940G>A	uc002xze.1	-	4	1598	c.1412C>T	c.(1411-1413)TCG>TTG	p.S471L	APCDD1L_uc010zzp.1_Missense_Mutation_p.S482L	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	471						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CTTCTGCAGCGATGGCCTGTG	0.627		NA											4	63					0	0	0	0
MRPL39	54148	broad.mit.edu	37	21	26972131	26972131	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:26972131C>G	uc002ylo.2	-	5	582	c.568G>C	c.(568-570)GAT>CAT	p.D190H	MRPL39_uc002yln.2_Missense_Mutation_p.D190H	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	190						mitochondrial ribosome	nucleotide binding				0						ATCCACTCATCAAGTTTGCTA	0.348		NA											3	57					0	0	0	0
UBE2G2	7327	broad.mit.edu	37	21	46193489	46193489	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:46193489G>A	uc002zfy.2	-	5	433	c.358C>T	c.(358-360)CTG>TTG	p.L120L	UBE2G2_uc002zfx.2_Silent_p.L92L	NM_003343	NP_003334	P60604	UB2G2_HUMAN	ubiquitin-conjugating enzyme E2G 2 isoform 1	120					protein K48-linked ubiquitination	cytosol	ATP binding|protein binding|ubiquitin-protein ligase activity			breast(3)|central_nervous_system(1)	4				Colorectal(79;0.0638)		ACCGACAGCAGGATCTTCTCC	0.637		NA											4	35					0	0	0	0
COL18A1	80781	broad.mit.edu	37	21	46875807	46875807	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:46875807C>T	uc011afs.1	+	1	384	c.363C>T	c.(361-363)ATC>ATT	p.I121I	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.I121I	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	121					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CCAAAGGCATCCGGAGCTTCG	0.642		NA											8	80					0	0	0	0
MCM3AP	8888	broad.mit.edu	37	21	47700039	47700039	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:47700039T>A	uc002zir.1	-	4	1571	c.1535A>T	c.(1534-1536)AAA>ATA	p.K512I		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	512					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					GGAAAAGGGTTTCTTATTGGG	0.483		NA											8	126					0	0	0	0
C22orf29	79680	broad.mit.edu	37	22	19839545	19839545	+	Silent	SNP	A	A	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr22:19839545A>T	uc002zqg.2	-	2	839	c.240T>A	c.(238-240)GGT>GGA	p.G80G	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Silent_p.G80G|C22orf29_uc002zqi.2_Silent_p.G80G|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	80											0	Colorectal(54;0.0993)					CAGCTAGGGGACCCCTTTCTG	0.627		NA											11	50					0	0	0	0
CHL1	10752	broad.mit.edu	37	3	369921	369921	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:369921G>A	uc003bou.2	+	5	540	c.269G>A	c.(268-270)GGA>GAA	p.G90E	CHL1_uc003bot.2_Missense_Mutation_p.G90E|CHL1_uc003bow.1_Missense_Mutation_p.G90E|CHL1_uc011asi.1_Missense_Mutation_p.G90E	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	90	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AACAATTCAGGAACATTCAGG	0.388		NA											6	94					0	0	0	0
CRYBG3	131544	broad.mit.edu	37	3	97598838	97598838	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:97598838T>A	uc003drx.2	+	3	1118	c.1054T>A	c.(1054-1056)TAT>AAT	p.Y352N		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						GATGGTTATCTATGATCTCCA	0.284		NA											10	59					0	0	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277533	140277533	+	Silent	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:140277533G>C	uc003etn.2	+	12	2065	c.1875G>C	c.(1873-1875)GTG>GTC	p.V625V		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	625	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						ATGCCTATGTGATGGTCCTCC	0.547		NA								HNSCC(16;0.037)			5	65					0	0	0	0
PHC3	80012	broad.mit.edu	37	3	169835109	169835109	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:169835109T>C	uc010hws.1	-	10	2126	c.2062A>G	c.(2062-2064)ATA>GTA	p.I688V	PHC3_uc003fgl.2_Missense_Mutation_p.I700V|PHC3_uc011bpq.1_Missense_Mutation_p.I647V	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	688					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTGTTCTCTATACTGGGAATG	0.448		NA											7	42					0	0	0	0
TP63	8626	broad.mit.edu	37	3	189526137	189526137	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:189526137A>G	uc003fry.2	+	4	490	c.401A>G	c.(400-402)TAT>TGT	p.Y134C	TP63_uc003frx.2_Missense_Mutation_p.Y134C|TP63_uc003frz.2_Missense_Mutation_p.Y134C|TP63_uc010hzc.1_Missense_Mutation_p.Y134C|TP63_uc003fsa.2_Missense_Mutation_p.Y40C|TP63_uc003fsb.2_Missense_Mutation_p.Y40C|TP63_uc003fsc.2_Missense_Mutation_p.Y40C|TP63_uc003fsd.2_Missense_Mutation_p.Y40C|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Missense_Mutation_p.Y15C	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	134					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCAGTCCCTATAACACAGAC	0.617		NA							Hay-Wells_syndrome	HNSCC(45;0.13)			15	80					0	0	0	0
EVC	2121	broad.mit.edu	37	4	5750014	5750014	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:5750014C>T	uc003gil.1	+	8	1263	c.1079C>T	c.(1078-1080)TCT>TTT	p.S360F	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Silent_p.E463E	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	360					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TTGTGCGATTCTCAGGAGCTG	0.488		NA											3	36					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187530345	187530345	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:187530345G>A	uc003izf.2	-	16	10386	c.10198C>T	c.(10198-10200)CGA>TGA	p.R3400*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3400	Extracellular (Potential).|Cadherin 31.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACCGTTTCTCGGTCGAGAAGT	0.453		NA								HNSCC(5;0.00058)			8	33					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187542660	187542660	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:187542660G>A	uc003izf.2	-	10	5268	c.5080C>T	c.(5080-5082)CAA>TAA	p.Q1694*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1694	Extracellular (Potential).|Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACTGATGATTGACTATGGGCT	0.393		NA								HNSCC(5;0.00058)			7	49					0	0	0	0
TRIML2	205860	broad.mit.edu	37	4	189022315	189022315	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:189022315C>G	uc003izl.2	-	3	261	c.225G>C	c.(223-225)CAG>CAC	p.Q75H	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.Q125H|TRIML2_uc011clf.1_Missense_Mutation_p.Q125H	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	75	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CCTGCTGTCTCTGGAGATTCT	0.428		NA											5	45					0	0	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	171485	171485	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:171485G>A	uc003jak.2	+	14	2958	c.2908G>A	c.(2908-2910)GCC>ACC	p.A970T		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	970	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GCTCCGAGCCGCCGAGGTCGT	0.677		NA											4	28					0	0	0	0
ADCY2	108	broad.mit.edu	37	5	7626401	7626401	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:7626401T>C	uc003jdz.1	+	4	759	c.692T>C	c.(691-693)ATC>ACC	p.I231T		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	231	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AAGTCGCGGATCAAGTTGGAA	0.398		NA											3	56					0	0	0	0
PIK3R1	5295	broad.mit.edu	37	5	67589628	67589628	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:67589628A>T	uc003jva.2	+	11	1951	c.1391A>T	c.(1390-1392)GAT>GTT	p.D464V	PIK3R1_uc003jvb.2_Missense_Mutation_p.D464V|PIK3R1_uc003jvc.2_Missense_Mutation_p.D164V|PIK3R1_uc003jvd.2_Missense_Mutation_p.D194V|PIK3R1_uc003jve.2_Missense_Mutation_p.D143V|PIK3R1_uc011crb.1_Missense_Mutation_p.D134V	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	464					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.D464fs*2(1)|p.?(1)|p.D464H(1)|p.Y463_L466del(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGAGAATATGATAGATTATAT	0.294		NA	Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			9	54					0	0	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948498	82948498	+	Silent	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:82948498G>T	uc003kim.2	-	2	317	c.246C>A	c.(244-246)ACC>ACA	p.T82T	HAPLN1_uc003kin.2_Silent_p.T82T	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	82	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		AAGTTAGCTTGGTCCACTTAA	0.423		NA											5	97					1.64e-10	1.81e-10	1	0
RASA1	5921	broad.mit.edu	37	5	86659189	86659189	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:86659189T>A	uc003kiw.2	+	11	1596	c.1478T>A	c.(1477-1479)TTA>TAA	p.L493*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.L316*|RASA1_uc011ctv.1_Nonsense_Mutation_p.L326*|RASA1_uc011ctw.1_Nonsense_Mutation_p.L327*|RASA1_uc010jaw.2_Nonsense_Mutation_p.L315*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	493	PH.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGGAAAAATTTATATTTTATC	0.289		NA											10	33					0	0	0	0
AQPEP	206338	broad.mit.edu	37	5	115327924	115327924	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:115327924G>A	uc003kro.2	+	5	1374	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	AQPEP_uc003krp.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	404	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TCAACTGACAGAAAAAAAGAC	0.388		NA											5	84					0	0	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214357	140214357	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:140214357C>G	uc003lhq.2	+	1	389	c.389C>G	c.(388-390)CCT>CGT	p.P130R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.P130R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	130	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACCCTCCGGTGTTC	0.592		NA											8	184					0	0	0	0
KIF4B	285643	broad.mit.edu	37	5	154393632	154393632	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:154393632G>A	uc010jih.1	+	1	373	c.213G>A	c.(211-213)CCG>CCA	p.P71P		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	71	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGTAGCGCCGCTCATAAAAG	0.463		NA											9	62					0	0	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24523069	24523069	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:24523069C>T	uc003neg.2	+	7	1117	c.1089C>T	c.(1087-1089)GCC>GCT	p.A363A	ALDH5A1_uc003nef.2_Silent_p.A376A	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	363					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TCGCCGAGGCCATGAAGAAGA	0.428		NA											10	106					0	0	0	0
ZNF391	346157	broad.mit.edu	37	6	27368887	27368887	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:27368887G>C	uc003njf.1	+	3	1256	c.738G>C	c.(736-738)GAG>GAC	p.E246D		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						ACACTGGAGAGAATCCCTATG	0.433		NA											3	44					0	0	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28327420	28327420	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:28327420G>A	uc003nle.3	+	2	273	c.57G>A	c.(55-57)CAG>CAA	p.Q19Q	ZKSCAN3_uc010jrc.2_Silent_p.Q19Q|ZKSCAN3_uc003nlf.3_Intron	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	19					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						CAGAAGACCAGATGGAGCTTC	0.562		NA											9	98					0	0	0	0
DLK2	65989	broad.mit.edu	37	6	43418618	43418618	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:43418618C>G	uc003ova.2	-	6	1020	c.811G>C	c.(811-813)GTG>CTG	p.V271L	DLK2_uc003ovb.2_Missense_Mutation_p.V271L	NM_023932	NP_076421	Q6UY11	DLK2_HUMAN	EGF-like-domain, multiple 9 precursor	271	Extracellular (Potential).					integral to membrane	calcium ion binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCAGGTACCACTACAGCTGAG	0.647		NA											6	63					0	0	0	0
PRDM1	639	broad.mit.edu	37	6	106553695	106553695	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:106553695A>G	uc003prd.2	+	5	1894	c.1660A>G	c.(1660-1662)AGA>GGA	p.R554G	PRDM1_uc003pre.2_Missense_Mutation_p.R420G	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	554					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TAAAAACAAAAGAAACATGAC	0.537		NA	D|N|Mis|F|S		DLBCL								4	50					0	0	0	0
C6orf170	221322	broad.mit.edu	37	6	121600334	121600334	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:121600334T>C	uc003pyo.1	-	15	1734	c.1666A>G	c.(1666-1668)ATT>GTT	p.I556V	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Missense_Mutation_p.I75V	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	556					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		ACAGATGCAATTCTTGCCAAA	0.328		NA											5	59					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152722368	152722368	+	Missense_Mutation	SNP	A	A	G	rs138004884	byFrequency	TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:152722368A>G	uc010kiw.2	-	47	7536	c.6934T>C	c.(6934-6936)TTT>CTT	p.F2312L	SYNE1_uc003qot.3_Missense_Mutation_p.F2319L|SYNE1_uc003qou.3_Missense_Mutation_p.F2312L|SYNE1_uc010kjb.1_Missense_Mutation_p.F2295L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2312	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCATTAATAAACTTCTCCACT	0.393		NA								HNSCC(10;0.0054)			4	66					0	0	0	0
NPSR1	387129	broad.mit.edu	37	7	34888178	34888178	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr7:34888178T>C	uc003teg.1	+	8	1056	c.928T>C	c.(928-930)TAT>CAT	p.Y310H	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.Y310H|NPSR1_uc010kwt.1_Missense_Mutation_p.Y157H|NPSR1_uc010kwu.1_Missense_Mutation_p.Y100H|NPSR1_uc010kwv.1_Missense_Mutation_p.Y244H|NPSR1_uc003tei.1_Missense_Mutation_p.Y310H|NPSR1_uc010kww.1_Missense_Mutation_p.Y299H|NPSR1_uc011kar.1_Missense_Mutation_p.Y244H	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	310	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	GGAGCGTTTCTATGCCTCTGT	0.498		NA											11	203					0	0	0	0
TRIM24	8805	broad.mit.edu	37	7	138269634	138269634	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr7:138269634G>A	uc003vuc.2	+	19	3306	c.3091G>A	c.(3091-3093)GAC>AAC	p.D1031N	TRIM24_uc003vub.2_Missense_Mutation_p.D997N	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	1031					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TTCAGATGATGACTTTGTACA	0.373		NA											4	46					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	11					0	0	0	0
TOPORS	10210	broad.mit.edu	37	9	32542338	32542338	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:32542338G>A	uc003zrb.2	-	3	2352	c.2185C>T	c.(2185-2187)CAT>TAT	p.H729Y	TOPORS_uc003zrc.2_Missense_Mutation_p.H662Y	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	729	Interaction with TOP1.|Arg-rich.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTAGAATAATGAGCTCTGGAC	0.378		NA											10	154					0	0	0	0
ABCA2	20	broad.mit.edu	37	9	139906446	139906446	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:139906446G>A	uc011mem.1	-	34	5530	c.5382C>T	c.(5380-5382)ATC>ATT	p.I1794I	ABCA2_uc011mel.1_Silent_p.I1795I|ABCA2_uc004ckl.1_Silent_p.I1725I|ABCA2_uc004ckm.1_Silent_p.I1825I	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1794	Helical; (Potential).				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGAAGATGGCGATGACGACAT	0.637		NA											4	48					0	0	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49032203	49032203	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chrX:49032203G>T	uc004dmy.1	-	9	1693	c.1667C>A	c.(1666-1668)TCA>TAA	p.S556*	PRICKLE3_uc011mmv.1_Nonsense_Mutation_p.S488*|PRICKLE3_uc011mmw.1_Nonsense_Mutation_p.S475*|PRICKLE3_uc011mmx.1_Nonsense_Mutation_p.S518*	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	556	Poly-Ser.						protein binding|zinc ion binding			breast(1)	1						ATCCTCTGATGATTCGGAACT	0.577		NA											15	75					1.15e-07	1.26e-07	1	0
HCFC1	3054	broad.mit.edu	37	X	153215722	153215722	+	Silent	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chrX:153215722G>C	uc004fjp.2	-	24	6504	c.5976C>G	c.(5974-5976)GGC>GGG	p.G1992G		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1992					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTGGCCGGGCCATAGCCCT	0.632		NA											7	32					0	0	0	0
CTBS	1486	broad.mit.edu	37	1	85039999	85040007	+	In_Frame_Del	DEL	GCAGCGCCA	GCAGCGCCA	-			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:85039999_85040007delGCAGCGCCA	uc001dka.2	-	1	157_165	c.92_100delTGGCGCTGC	c.(91-102)CTGGCGCTGCGG>CGG	p.LAL31del	CTBS_uc001dkc.2_5'UTR|CTBS_uc001dkd.2_5'UTR|CTBS_uc001dkb.2_5'UTR	NM_004388	NP_004379	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl- precursor	31_33						lysosome	cation binding				0				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		GCCGCGAGCCgcagcgccagcagcgccag	0.589		NA											2	4	---	---	---	---	NA	NA	NA	NA
EIF4G1	1981	broad.mit.edu	37	3	184045767	184045767	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:184045767delG	uc003fnp.2	+	26	4128	c.3930delG	c.(3928-3930)CTGfs	p.L1310fs	EIF4G1_uc003fnt.2_Frame_Shift_Del_p.L1021fs|EIF4G1_uc003fnq.2_Frame_Shift_Del_p.L1223fs|EIF4G1_uc003fnr.2_Frame_Shift_Del_p.L1146fs|EIF4G1_uc010hxx.2_Frame_Shift_Del_p.L1317fs|EIF4G1_uc003fns.2_Frame_Shift_Del_p.L1270fs|EIF4G1_uc010hxy.2_Frame_Shift_Del_p.L1317fs|EIF4G1_uc003fnv.3_Frame_Shift_Del_p.L1311fs|EIF4G1_uc003fnu.3_Frame_Shift_Del_p.L1310fs|EIF4G1_uc003fnw.2_Frame_Shift_Del_p.L1317fs|EIF4G1_uc003fnx.2_Frame_Shift_Del_p.L1115fs|EIF4G1_uc003fny.3_Frame_Shift_Del_p.L1114fs|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1310	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTGGGCATCTGTCTACTGCTC	0.537		NA											7	113	---	---	---	---	NA	NA	NA	NA