Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
TMEM39B	55116	broad.mit.edu	37	1	32542834	32542834	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:32542834A>G	uc010ogv.1	+	5	651	c.505A>G	c.(505-507)ACG>GCG	p.T169A	TMEM39B_uc010ogt.1_Intron|TMEM39B_uc010ogu.1_Missense_Mutation_p.T42A|TMEM39B_uc001bue.3_Missense_Mutation_p.T169A|TMEM39B_uc001buf.3_Intron|TMEM39B_uc010ogw.1_Intron	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	169	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CACCGTTCTCACGGCAACAGG	0.597		NA											4	99					0	0	0	0
MARCKSL1	65108	broad.mit.edu	37	1	32800482	32800482	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:32800482C>T	uc001bvd.2	-	2	504	c.304G>A	c.(304-306)GGC>AGC	p.G102S		NM_023009	NP_075385	P49006	MRP_HUMAN	MARCKS-like 1	102						plasma membrane	calmodulin binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AAGGACAGGCCGCTCAATTTG	0.577		NA											3	54					0	0	0	0
GRIK3	2899	broad.mit.edu	37	1	37337839	37337839	+	Missense_Mutation	SNP	G	G	A	rs141595955		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:37337839G>A	uc001caz.2	-	4	817	c.682C>T	c.(682-684)CGC>TGC	p.R228C	GRIK3_uc001cba.1_Missense_Mutation_p.R228C	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	228	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AAGATAATGCGGAATTCCCGG	0.597		NA											14	23					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NA											4	64					0	0	0	0
RD3	343035	broad.mit.edu	37	1	211652474	211652474	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:211652474G>A	uc001him.2	-	3	1656	c.492C>T	c.(490-492)AGC>AGT	p.S164S	RD3_uc001hin.2_RNA|RD3_uc009xda.2_RNA	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	164					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		TCCTGATGTCGCTGGCGAAGG	0.701		NA											9	13					0	0	0	0
DISC1	27185	broad.mit.edu	37	1	232162197	232162197	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:232162197C>T	uc001huz.2	+	12	2377	c.2324C>T	c.(2323-2325)TCT>TTT	p.S775F	TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pxh.1_Missense_Mutation_p.S807F|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.S398F|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.S653F|DISC1_uc010pxn.1_Missense_Mutation_p.S420F|DISC1_uc001hva.2_Missense_Mutation_p.S753F	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	775	Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with ATF4 and ATF5.|Interaction with PAFAH1B1.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				TACATCCTTTCTGCAGAACTT	0.443		NA											4	6					0	0	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687277	27687277	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:27687277G>A	uc001itu.2	-	4	2368	c.2250C>T	c.(2248-2250)TTC>TTT	p.F750F		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	750					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TTGTCTGAATGAAGCCCCGGG	0.318		NA											4	24					0	0	0	0
LYZL1	84569	broad.mit.edu	37	10	29581596	29581596	+	Silent	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:29581596C>T	uc001iul.2	+	3	483	c.426C>T	c.(424-426)GTC>GTT	p.V142V		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	96					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				ACTGCCATGTCGCCTGCTCAG	0.537		NA											15	54					0	0	0	0
TET1	80312	broad.mit.edu	37	10	70405630	70405630	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:70405630C>A	uc001jok.3	+	4	3649	c.3144C>A	c.(3142-3144)TGC>TGA	p.C1048*		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1048					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TGGAGTATTGCAACCAGTTAC	0.388		NA											18	80					2.94e-08	3.3e-08	1	0
FAM190B	54462	broad.mit.edu	37	10	86131078	86131078	+	Silent	SNP	T	T	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:86131078T>C	uc001kdh.1	+	2	464	c.270T>C	c.(268-270)GAT>GAC	p.D90D	FAM190B_uc001kdg.1_Silent_p.D90D|FAM190B_uc010qmd.1_Silent_p.D90D	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	90										ovary(3)|skin(1)	4						ATTCACATGATAAAATAATTG	0.328		NA											3	46					0	0	0	0
TAF5	6877	broad.mit.edu	37	10	105146990	105146990	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:105146990G>T	uc001kwv.2	+	9	1911	c.1888G>T	c.(1888-1890)GTG>TTG	p.V630L	TAF5_uc010qqq.1_Missense_Mutation_p.V575L	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	630	WD 4.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		TCTTGCTGATGTGAATTGTAC	0.423		NA											21	39					7.45e-12	8.54e-12	1	0
PLEKHA1	59338	broad.mit.edu	37	10	124186509	124186509	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:124186509A>G	uc001lge.1	+	11	985	c.862A>G	c.(862-864)ATT>GTT	p.I288V	PLEKHA1_uc001lgf.1_Missense_Mutation_p.I288V|PLEKHA1_uc001lgg.1_Missense_Mutation_p.I288V|PLEKHA1_uc001lgh.2_Missense_Mutation_p.I288V	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	288	PH 2.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCTGGCGCCATTGTAGCACA	0.473		NA											21	43					0	0	0	0
DPYSL4	10570	broad.mit.edu	37	10	134008356	134008356	+	Silent	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:134008356C>T	uc009ybb.2	+	4	475	c.321C>T	c.(319-321)CAC>CAT	p.H107H		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	107					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CAGTGGACCACGTCTTCCCCG	0.642		NA											26	77					0	0	0	0
TOLLIP	54472	broad.mit.edu	37	11	1309866	1309866	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:1309866G>A	uc001lte.2	-	4	618	c.507C>T	c.(505-507)GTC>GTT	p.V169V	TOLLIP_uc001ltd.2_Silent_p.V100V|TOLLIP_uc009ycu.2_Silent_p.V108V|TOLLIP_uc001ltf.2_Silent_p.V119V	NM_019009	NP_061882	Q9H0E2	TOLIP_HUMAN	toll interacting protein	169					cell-cell signaling|inflammatory response|innate immune response|intracellular signal transduction|leukocyte activation|phosphorylation	cytosol|interleukin-1 receptor complex|interleukin-18 receptor complex	kinase binding|signal transducer activity|Toll-like receptor binding				0		all_cancers(49;7.62e-05)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00152)|Lung(200;0.09)|LUSC - Lung squamous cell carcinoma(625;0.107)		CGTAGGACATGACGAGGTTGA	0.647		NA											13	25					0	0	0	0
NELL1	4745	broad.mit.edu	37	11	21594899	21594899	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:21594899C>G	uc001mqe.2	+	19	2479	c.2326C>G	c.(2326-2328)CTT>GTT	p.L776V	NELL1_uc001mqf.2_Missense_Mutation_p.L729V|NELL1_uc009yid.2_Missense_Mutation_p.L804V|NELL1_uc010rdo.1_Missense_Mutation_p.L719V|NELL1_uc010rdp.1_Missense_Mutation_p.L489V|NELL1_uc001mqh.2_Missense_Mutation_p.L321V	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	776	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGTTTCACGGCTTAGTGGCTC	0.493		NA											10	107					0	0	0	0
CFL1	1072	broad.mit.edu	37	11	65623573	65623573	+	Silent	SNP	G	G	A	rs144718277		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:65623573G>A	uc001ofs.2	-	2	378	c.144C>T	c.(142-144)ATC>ATT	p.I48I	CFL1_uc001oft.2_Silent_p.I48I|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	48	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		CCTCCTCCAGGATGATGTTCT	0.562		NA											5	54					0	0	0	0
CFL1	1072	broad.mit.edu	37	11	65623576	65623576	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:65623576G>A	uc001ofs.2	-	2	375	c.141C>T	c.(139-141)ATC>ATT	p.I47I	CFL1_uc001oft.2_Silent_p.I47I|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	47	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		CCTCCAGGATGATGTTCTTCT	0.557		NA											4	58					0	0	0	0
PZP	5858	broad.mit.edu	37	12	9349218	9349218	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:9349218C>G	uc001qvl.2	-	9	960	c.931G>C	c.(931-933)GGC>CGC	p.G311R	PZP_uc009zgl.2_Missense_Mutation_p.G180R	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						ATTTCAAAGCCCGTATTTGTA	0.393		NA											20	58					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49447022	49447022	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:49447022C>A	uc001rta.3	-	7	922	c.922G>T	c.(922-924)GAG>TAG	p.E308*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	308	PHD-type 2.|RING-type 2; degenerate.|Cys-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCAGTTCCTCCATGGGTGGT	0.478		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			25	92					1.32e-05	1.46e-05	1	0
CCNA1	8900	broad.mit.edu	37	13	37014297	37014297	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr13:37014297G>A	uc001uvr.3	+	6	1425	c.1075G>A	c.(1075-1077)GTC>ATC	p.V359I	CCNA1_uc010teo.1_Missense_Mutation_p.V315I|CCNA1_uc010abq.2_Missense_Mutation_p.V315I|CCNA1_uc010abp.2_Missense_Mutation_p.V315I|CCNA1_uc001uvs.3_Missense_Mutation_p.V358I|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	359					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		AGGAGTGTGCGTCAGGACTGA	0.463		NA											30	24					0	0	0	0
STRN3	29966	broad.mit.edu	37	14	31380280	31380280	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr14:31380280G>A	uc001wqu.2	-	13	1903	c.1687C>T	c.(1687-1689)CCG>TCG	p.P563S	STRN3_uc001wqv.2_Missense_Mutation_p.P479S|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	563	WD 2.				negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		CTGGGACTCGGCATATTCCAC	0.368		NA											3	70					0	0	0	0
BAHD1	22893	broad.mit.edu	37	15	40758306	40758306	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr15:40758306C>T	uc001zlu.2	+	7	2391	c.2320C>T	c.(2320-2322)CGC>TGC	p.R774C	BAHD1_uc001zlt.2_Missense_Mutation_p.R773C|BAHD1_uc010bbp.1_Missense_Mutation_p.R770C|BAHD1_uc001zlv.2_Missense_Mutation_p.R771C	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	774	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCGCCACGGGCGCATCCTTAA	0.622		NA											20	64					0	0	0	0
ZFAND6	54469	broad.mit.edu	37	15	80412738	80412738	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr15:80412738T>G	uc002bfe.1	+	3	363	c.52T>G	c.(52-54)TGT>GGT	p.C18G	ZFAND6_uc002bff.1_Missense_Mutation_p.C18G|ZFAND6_uc002bfg.1_Missense_Mutation_p.C18G|ZFAND6_uc002bfh.1_Missense_Mutation_p.C18G|ZFAND6_uc002bfi.1_Missense_Mutation_p.C18G	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	18	A20-type.						DNA binding|zinc ion binding				0						TTCCACTGGCTGTGGATTTTA	0.393		NA											29	58					0	0	0	0
HYDIN	54768	broad.mit.edu	37	16	70891747	70891747	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr16:70891747A>T	uc002ezr.2	-	72	12281	c.12153T>A	c.(12151-12153)CAT>CAA	p.H4051Q	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4052										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGATGCCCAGATGGAAAGGTG	0.468		NA											3	9					0	0	0	0
SLC13A5	284111	broad.mit.edu	37	17	6599181	6599181	+	Silent	SNP	G	G	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:6599181G>T	uc002gdj.2	-	7	1007	c.919C>A	c.(919-921)CGG>AGG	p.R307R	SLC13A5_uc010vtf.1_Silent_p.R307R|SLC13A5_uc010clq.2_Silent_p.R264R|SLC13A5_uc002gdk.2_Silent_p.R290R|SLC13A5_uc002gdl.1_Silent_p.R289R	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	307						integral to membrane	citrate transmembrane transporter activity				0						CCCAGCTTCCGGTACTCCTCC	0.567		NA											26	156					6.07e-21	7.09e-21	1	0
DNAH9	1770	broad.mit.edu	37	17	11725866	11725866	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:11725866G>C	uc002gne.2	+	47	9030	c.8962G>C	c.(8962-8964)GCA>CCA	p.A2988P	DNAH9_uc010coo.2_Missense_Mutation_p.A2282P	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2988	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCCTCAGCAAGCATTGGAGTC	0.532		NA											7	175					0	0	0	0
KRT39	390792	broad.mit.edu	37	17	39118800	39118800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:39118800G>A	uc002hvo.1	-	4	760	c.724C>T	c.(724-726)CAG>TAG	p.Q242*	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	242	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				AGCTGACACTGTAAAGAATTG	0.418		NA											4	133					0	0	0	0
KRT36	8689	broad.mit.edu	37	17	39644901	39644901	+	Missense_Mutation	SNP	G	G	A	rs148033888	byFrequency	TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:39644901G>A	uc002hwt.2	-	2	535	c.535C>T	c.(535-537)CGG>TGG	p.R179W		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	179	Rod.|Coil 1B.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CACTTGGTCCGGAAGTCGTCA	0.552		NA											23	42					0	0	0	0
TRIM37	4591	broad.mit.edu	37	17	57125153	57125153	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:57125153G>A	uc002iwy.3	-	16	2002	c.1558C>T	c.(1558-1560)CTG>TTG	p.L520L	TRIM37_uc002iwz.3_Silent_p.L520L|TRIM37_uc002ixa.3_Silent_p.L398L|TRIM37_uc010woc.1_Silent_p.L486L	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	520						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					ACAAGATCCAGATCCAGATCT	0.418		NA							Mulibrey_Nanism				5	57					0	0	0	0
ZNF236	7776	broad.mit.edu	37	18	74611013	74611013	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr18:74611013T>A	uc002lmi.2	+	11	1921	c.1723T>A	c.(1723-1725)TTT>ATT	p.F575I	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	575	C2H2-type 13.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TGACAAAAAATTTCGAACCTC	0.383		NA											5	63					0	0	0	0
ZNF700	90592	broad.mit.edu	37	19	12058339	12058339	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr19:12058339G>C	uc002msu.2	+	3	327	c.201G>C	c.(199-201)TGG>TGC	p.W67C	ZNF700_uc010xme.1_Missense_Mutation_p.W85C|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAAAAAATGGAGTGACCAGA	0.358		NA											3	89					0	0	0	0
ZNF526	116115	broad.mit.edu	37	19	42728645	42728645	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr19:42728645G>A	uc002osz.1	+	3	246	c.90G>A	c.(88-90)ATG>ATA	p.M30I		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				CGGCAGAGATGATGGAGATGT	0.557		NA											5	85					0	0	0	0
ZNF761	388561	broad.mit.edu	37	19	53959551	53959551	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr19:53959551A>G	uc010eqp.2	+	7	2248	c.1790A>G	c.(1789-1791)CAG>CGG	p.Q597R	ZNF761_uc010ydy.1_Missense_Mutation_p.Q543R|ZNF761_uc002qbt.1_Missense_Mutation_p.Q543R	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	597	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GAAATACATCAGAAAATTCAT	0.408		NA											24	60					0	0	0	0
GCKR	2646	broad.mit.edu	37	2	27728586	27728586	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:27728586C>T	uc002rky.2	+	10	818	c.752C>T	c.(751-753)CCC>CTC	p.P251L	GCKR_uc010ezd.2_Missense_Mutation_p.P251L|GCKR_uc010ylu.1_Missense_Mutation_p.P61L	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	251	SIS 1.			P -> V (in Ref. 2; CAB61828).	carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					CCTCTTCAGCCCGAGGGTCTC	0.552		NA											8	54					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116534856	116534856	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:116534856G>A	uc002tla.1	+	14	1751	c.1294G>A	c.(1294-1296)GAT>AAT	p.D432N	DPP10_uc002tlb.1_Missense_Mutation_p.D382N|DPP10_uc002tlc.1_Missense_Mutation_p.D428N|DPP10_uc002tle.2_Missense_Mutation_p.D436N|DPP10_uc002tlf.1_Missense_Mutation_p.D425N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	432	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CTTGGCATACGATGAAACTAC	0.358		NA											9	36					0	0	0	0
PDE11A	50940	broad.mit.edu	37	2	178682613	178682613	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:178682613A>G	uc002ulq.2	-	8	1934	c.1616T>C	c.(1615-1617)TTT>TCT	p.F539S	PDE11A_uc002ulp.2_Missense_Mutation_p.F95S|PDE11A_uc002ulr.2_Missense_Mutation_p.F289S|PDE11A_uc002uls.1_Missense_Mutation_p.F181S|PDE11A_uc002ult.1_Missense_Mutation_p.F289S|PDE11A_uc002ulu.1_Missense_Mutation_p.F181S	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	539	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGCATCATCAAAAGGTTTCCC	0.378		NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				5	34					0	0	0	0
BOLL	66037	broad.mit.edu	37	2	198636708	198636708	+	Splice_Site	SNP	T	T	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:198636708T>G	uc002uus.2	-	6	663	c.353_splice	c.e6-1	p.R118_splice	uc002uup.2_Intron|BOLL_uc002uur.2_Splice_Site_p.R124_splice|BOLL_uc002uut.2_Splice_Site_p.R130_splice|BOLL_uc010zha.1_Splice_Site_p.G9_splice|BOLL_uc002uuu.1_Splice_Site_p.R124_splice	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2						cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						TACTAGAACCTAAAGCAAAGA	0.279		NA											16	87					0	0	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119916	38119916	+	Silent	SNP	C	C	T	rs55853304		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:38119916C>T	uc003atr.2	+	7	1624	c.1353C>T	c.(1351-1353)CCC>CCT	p.P451P	TRIOBP_uc003atu.2_Silent_p.P279P|TRIOBP_uc003atq.1_Silent_p.P451P|TRIOBP_uc003ats.1_Silent_p.P279P	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	451					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GAGACAACCCCACAACATCCT	0.602		NA											8	47					0	0	0	0
MKL1	57591	broad.mit.edu	37	22	40817050	40817050	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:40817050C>A	uc003ayv.1	-	7	889	c.682G>T	c.(682-684)GAG>TAG	p.E228*	MKL1_uc003ayw.1_Nonsense_Mutation_p.E228*|MKL1_uc010gye.1_Nonsense_Mutation_p.E228*|MKL1_uc010gyf.1_Nonsense_Mutation_p.E178*	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	228	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGCTTCAGCTCCTTGGCCTTC	0.597		NA	T	RBM15	acute megakaryocytic leukemia								6	77					8.13e-05	8.92e-05	1	0
SLC25A17	10478	broad.mit.edu	37	22	41173340	41173340	+	Silent	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:41173340C>T	uc003azc.2	-	6	629	c.489G>A	c.(487-489)TCG>TCA	p.S163S	SLC25A17_uc010gyg.2_RNA|SLC25A17_uc011aou.1_Silent_p.S126S|SLC25A17_uc003azd.2_RNA|SLC25A17_uc011aov.1_Silent_p.S90S	NM_006358	NP_006349	O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier;	163	Solcar 2.|Helical; Name=4; (Potential).				fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding				0						TCCATAAAGCCGAGATTCCTT	0.408		NA											13	26					0	0	0	0
SBF1	6305	broad.mit.edu	37	22	50903692	50903692	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:50903692G>T	uc003blh.2	-	11	1350	c.1155C>A	c.(1153-1155)TGC>TGA	p.C385*	SBF1_uc011arx.1_Nonsense_Mutation_p.C49*|SBF1_uc003bli.2_Nonsense_Mutation_p.C386*	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	385	dDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGACGTGCAGGCACCAGCGAT	0.642		NA											4	7					2.56e-06	2.84e-06	1	0
MYRIP	25924	broad.mit.edu	37	3	40085595	40085595	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:40085595G>A	uc003cka.2	+	3	300	c.165G>A	c.(163-165)AAG>AAA	p.K55K	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.K55K|MYRIP_uc010hhw.2_Missense_Mutation_p.S12N|MYRIP_uc010hhx.1_Silent_p.K55K	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	55	RabBD.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TCCTCTCGAAGCACCAGCAGT	0.542		NA											4	32					0	0	0	0
NKTR	4820	broad.mit.edu	37	3	42659092	42659092	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:42659092A>G	uc003clo.2	+	3	236	c.89A>G	c.(88-90)GAC>GGC	p.D30G	NKTR_uc003cll.1_Missense_Mutation_p.D30G|NKTR_uc003clm.1_5'UTR|NKTR_uc003clp.2_5'UTR|NKTR_uc011azp.1_5'UTR|NKTR_uc003clq.1_5'Flank	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	30	PPIase cyclophilin-type.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CTCTTCTCAGACATATGTCCA	0.328		NA											10	42					0	0	0	0
NBEAL2	23218	broad.mit.edu	37	3	47044464	47044464	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:47044464G>A	uc003cqp.2	+	34	5656	c.5477G>A	c.(5476-5478)CGC>CAC	p.R1826H	NBEAL2_uc010hjm.1_Missense_Mutation_p.R1203H|NBEAL2_uc010hjn.1_Missense_Mutation_p.R222H|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1826							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCCATCCCCCGCTGGAAACTG	0.612		NA											16	19					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432746	73432746	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:73432746G>A	uc003dpl.1	-	10	3067	c.2971C>T	c.(2971-2973)CGG>TGG	p.R991W	PDZRN3_uc011bgh.1_Missense_Mutation_p.R648W|PDZRN3_uc010hoe.1_Missense_Mutation_p.R689W|PDZRN3_uc011bgf.1_Missense_Mutation_p.R708W|PDZRN3_uc011bgg.1_Missense_Mutation_p.R711W	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	991	Potential.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AACTCGCGCCGCCGCCGCTGC	0.582		NA											14	72					0	0	0	0
OR5K4	403278	broad.mit.edu	37	3	98073476	98073476	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:98073476G>C	uc011bgv.1	+	1	779	c.779G>C	c.(778-780)GGA>GCA	p.G260A		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ATGTATATTGGACCATCTGAA	0.348		NA											4	178					0	0	0	0
SIDT1	54847	broad.mit.edu	37	3	113331029	113331029	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:113331029C>T	uc003eak.2	+	19	2605	c.1954C>T	c.(1954-1956)CGT>TGT	p.R652C	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.R652C|SIDT1_uc011big.1_Missense_Mutation_p.R405C|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_Missense_Mutation_p.R105C	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	652	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						TTATATGGGTCGTTTCAAGAT	0.413		NA											5	65					0	0	0	0
KIAA1407	57577	broad.mit.edu	37	3	113723577	113723577	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:113723577G>C	uc003eax.2	-	11	2032	c.1885C>G	c.(1885-1887)CCT>GCT	p.P629A	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.P607A	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	629										ovary(2)	2						TCAGTCCCAGGGGAAGCAACA	0.423		NA											27	188					0	0	0	0
HEG1	57493	broad.mit.edu	37	3	124692701	124692701	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:124692701G>C	uc003ehs.3	-	16	3938	c.3870C>G	c.(3868-3870)TTC>TTG	p.F1290L	HEG1_uc003ehr.3_Missense_Mutation_p.F144L|HEG1_uc011bke.1_Missense_Mutation_p.F1390L	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	1290	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GGGACATTTGGAAATCTCCAC	0.383		NA											4	98					0	0	0	0
RHO	6010	broad.mit.edu	37	3	129251571	129251571	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:129251571G>A	uc003emt.2	+	4	987	c.892G>A	c.(892-894)GCC>ACC	p.A298T		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	298	Helical; Name=7; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TGCCAAGAGCGCCGCCATCTA	0.602		NA											7	111					0	0	0	0
KCNMB2	10242	broad.mit.edu	37	3	178543544	178543544	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:178543544G>A	uc003fjd.2	+	3	568	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Silent_p.Q75Q|KCNMB2_uc003fjf.2_Silent_p.Q75Q|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	75	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			CATACATGCAGAGGTAATACC	0.527		NA											47	255					0	0	0	0
TFRC	7037	broad.mit.edu	37	3	195792459	195792459	+	Silent	SNP	T	T	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:195792459T>C	uc003fvz.3	-	10	1336	c.1053A>G	c.(1051-1053)GGA>GGG	p.G351G	TFRC_uc003fwa.3_Silent_p.G351G|TFRC_uc010hzy.2_Silent_p.G270G|TFRC_uc011btr.1_Silent_p.G69G	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	351	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AGGGACAGTCTCCTTCCATAT	0.438		NA	T	BCL6	NHL								19	180					0	0	0	0
FSTL5	56884	broad.mit.edu	37	4	162307361	162307361	+	Silent	SNP	C	C	T	rs35820116	byFrequency	TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr4:162307361C>T	uc003iqh.2	-	16	2518	c.2082G>A	c.(2080-2082)ACG>ACA	p.T694T	FSTL5_uc003iqi.2_Silent_p.T693T|FSTL5_uc010iqv.2_Silent_p.T684T|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	694						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATGGAGTGCCCGTCACATCAC	0.478		NA											4	49					0	0	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370498	38370498	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:38370498G>A	uc003jlc.1	+	6	970	c.646G>A	c.(646-648)GTG>ATG	p.V216M	EGFLAM_uc003jlb.1_Missense_Mutation_p.V216M	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	216	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CCAGTTTGCCGTGAGGGCAAT	0.567		NA											6	31					0	0	0	0
ITGA1	3672	broad.mit.edu	37	5	52235492	52235492	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:52235492A>G	uc003jou.2	+	25	3203	c.3151A>G	c.(3151-3153)ACT>GCT	p.T1051A	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.T582A	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	1051	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GACTACATCAACTGACCATCT	0.323		NA											31	37					0	0	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626678	140626678	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:140626678G>T	uc003lje.2	+	1	1532	c.1532G>T	c.(1531-1533)GGC>GTC	p.G511V		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	511	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGACAACGGCCACCTGTTC	0.682		NA											29	89					1.75e-13	2.02e-13	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140723799	140723799	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:140723799G>A	uc003ljm.1	+	1	199	c.199G>A	c.(199-201)GTC>ATC	p.V67I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.V67I	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCCGCATCGTCTCCAGAGG	0.617		NA									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	163					0	0	0	0
UNC5A	90249	broad.mit.edu	37	5	176295646	176295646	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:176295646A>G	uc003mey.2	+	4	713	c.521A>G	c.(520-522)GAG>GGG	p.E174G	UNC5A_uc003mex.1_Missense_Mutation_p.E174G|UNC5A_uc010jkg.1_Missense_Mutation_p.E134G	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	174	Ig-like C2-type.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGTCCACCGGAGGGCATCCCT	0.662		NA											3	11					0	0	0	0
MBOAT1	154141	broad.mit.edu	37	6	20126818	20126818	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:20126818A>G	uc003ncx.1	-	7	849	c.644T>C	c.(643-645)ATA>ACA	p.I215T	MBOAT1_uc011dji.1_Missense_Mutation_p.I66T	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	215					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			CTTCATGTGTATATGCTTCCC	0.408		NA									OREG0017224	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	135					0	0	0	0
C6orf27	80737	broad.mit.edu	37	6	31734251	31734251	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:31734251C>T	uc011dog.1	-	14	2411	c.2173G>A	c.(2173-2175)GTC>ATC	p.V725I	C6orf27_uc003nxd.2_Missense_Mutation_p.V400I	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	725						extracellular region				ovary(3)	3						TCCAGAAGGACAGGGACTACA	0.652		NA											10	4					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977694	46977694	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:46977694C>T	uc003oyt.2	-	11	1676	c.1477G>A	c.(1477-1479)GTT>ATT	p.V493I	GPR110_uc011dwl.1_Missense_Mutation_p.V181I	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	493	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TTTTTGGAAACGGGTAGAATG	0.408		NA											7	67					0	0	0	0
FIG4	9896	broad.mit.edu	37	6	110106193	110106193	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:110106193C>T	uc003ptt.2	+	17	2125	c.1910C>T	c.(1909-1911)CCA>CTA	p.P637L	FIG4_uc011eau.1_Missense_Mutation_p.P360L	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	637					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		TGGTGGACACCAGAGGTGATA	0.269		NA											10	90					0	0	0	0
ZNF479	90827	broad.mit.edu	37	7	57187579	57187579	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr7:57187579G>A	uc010kzo.2	-	5	1814	c.1543C>T	c.(1543-1545)CAC>TAC	p.H515Y		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	515	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTCCAGTGTGAATTATCTTA	0.348		NA											5	20					0	0	0	0
ZNF394	84124	broad.mit.edu	37	7	99097569	99097569	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr7:99097569C>T	uc003uqs.2	-	1	309	c.148G>A	c.(148-150)GAG>AAG	p.E50K	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.E50K	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	50					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TAGTTGGGCTCCCAACTTCCG	0.642		NA											8	57					0	0	0	0
TAS2R16	50833	broad.mit.edu	37	7	122634844	122634844	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr7:122634844G>A	uc003vkl.1	-	1	911	c.845C>T	c.(844-846)ACG>ATG	p.T282M		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	282	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						CCTTTTCAACGTAGGGCTGCT	0.423		NA											27	109					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	2976061	2976061	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr8:2976061T>C	uc011kwk.1	-	42	6683	c.6293A>G	c.(6292-6294)TAC>TGC	p.Y2098C	CSMD1_uc011kwj.1_Missense_Mutation_p.Y1490C|CSMD1_uc010lrg.2_Missense_Mutation_p.Y166C	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2098	Extracellular (Potential).|Sushi 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTGATCATGTACCCATTCTG	0.418		NA											22	56					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110447468	110447468	+	Silent	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr8:110447468C>T	uc003yne.2	+	29	3494	c.3390C>T	c.(3388-3390)CCC>CCT	p.P1130P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1130	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACATGCCCCCGTTGCTGTGT	0.408		NA								HNSCC(38;0.096)			55	83					0	0	0	0
LINGO2	158038	broad.mit.edu	37	9	27949442	27949442	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:27949442G>T	uc003zqu.1	-	2	1422	c.1228C>A	c.(1228-1230)CCC>ACC	p.P410T	LINGO2_uc010mjf.1_Missense_Mutation_p.P410T|LINGO2_uc003zqv.1_Missense_Mutation_p.P410T	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	410	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGATTTTGGGTTTTTTGCAG	0.488		NA											12	73					4.37e-10	4.96e-10	1	0
PAX5	5079	broad.mit.edu	37	9	37015016	37015016	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:37015016G>A	uc003zzo.1	-	3	836	c.388C>T	c.(388-390)CCT>TCT	p.P130S	PAX5_uc011lpw.1_Missense_Mutation_p.P130S|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_Missense_Mutation_p.P22S|PAX5_uc010mls.1_Missense_Mutation_p.P130S|PAX5_uc011lpz.1_Missense_Mutation_p.P130S|PAX5_uc011lqa.1_Missense_Mutation_p.P22S|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.P130S|PAX5_uc010mlp.1_Missense_Mutation_p.P130S|PAX5_uc011lqc.1_Missense_Mutation_p.P130S|PAX5_uc010mlr.1_Missense_Mutation_p.P130S|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	130	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)|p.N126_P130>RA(1)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTGACGCTAGGCACGGTGTCA	0.572		NA	T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								10	161					0	0	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88193977	88193977	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:88193977G>A	uc011ltd.1	-	23	3233	c.3200C>T	c.(3199-3201)GCA>GTA	p.A1067V	AGTPBP1_uc004aod.3_Missense_Mutation_p.A693V|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.A1027V|AGTPBP1_uc011lte.1_Missense_Mutation_p.A1079V	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1067					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						CATGCAAAATGCTGGGGCGAT	0.338		NA											44	35					0	0	0	0
FAM75C1	441452	broad.mit.edu	37	9	90538055	90538055	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:90538055C>T	uc010mqi.2	+	4	3262	c.3233C>T	c.(3232-3234)GCG>GTG	p.A1078V	FAM75C1_uc004apq.3_Missense_Mutation_p.A1061V	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CTTTGCCATGCGCGCCATGCC	0.527		NA											5	116					0	0	0	0
ROR2	4920	broad.mit.edu	37	9	94486331	94486331	+	Silent	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:94486331C>T	uc004arj.1	-	9	2644	c.2445G>A	c.(2443-2445)CCG>CCA	p.P815P	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	815	Cytoplasmic (Potential).|Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						CGTAGAGCTGCGGCGGGGGCA	0.677		NA											8	78					0	0	0	0
ZNF484	83744	broad.mit.edu	37	9	95609543	95609543	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:95609543G>T	uc004asu.1	-	5	1675	c.1526C>A	c.(1525-1527)TCA>TAA	p.S509*	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Nonsense_Mutation_p.S511*|ZNF484_uc010mrb.1_Nonsense_Mutation_p.S473*|ZNF484_uc004asv.1_Nonsense_Mutation_p.S473*	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	509	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATGAGATTTGACCTGTCAGT	0.393		NA											42	131					2.2e-31	2.58e-31	1	0
GABBR2	9568	broad.mit.edu	37	9	101470780	101470780	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:101470780G>A	uc004ays.2	-	1	396	c.240C>T	c.(238-240)GCC>GCT	p.A80A		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	80	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CCAGTTCCACGGCGGGGAGCA	0.627		NA											11	8					0	0	0	0
DBC1	1620	broad.mit.edu	37	9	121930087	121930087	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:121930087G>A	uc004bkc.2	-	8	2017	c.1561C>T	c.(1561-1563)CGC>TGC	p.R521C		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	521					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						ATGCGCTTGCGCCACCGAGGG	0.562		NA											20	28					0	0	0	0
FNBP1	23048	broad.mit.edu	37	9	132740855	132740855	+	Silent	SNP	G	G	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:132740855G>A	uc004byw.1	-	4	453	c.234C>T	c.(232-234)AAC>AAT	p.N78N	FNBP1_uc011mbv.1_Silent_p.N78N|FNBP1_uc011mbw.1_Silent_p.N78N|FNBP1_uc004bza.2_Silent_p.N78N|FNBP1_uc004byz.1_Silent_p.N78N|FNBP1_uc004byx.1_Translation_Start_Site|FNBP1_uc004byy.1_Translation_Start_Site	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	78	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		CATTCATTTCGTTCAGGTTGG	0.433		NA	T	MLL	AML								8	49					0	0	0	0
LAMC3	10319	broad.mit.edu	37	9	133907471	133907471	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:133907471C>T	uc004caa.1	+	3	816	c.718C>T	c.(718-720)CGG>TGG	p.R240W		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	240	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTCTCTAGACCGGCTCAACAC	0.567		NA											10	149					0	0	0	0
PARD3	56288	broad.mit.edu	37	10	34671799	34671808	+	Frame_Shift_Del	DEL	ATGGAACCAA	ATGGAACCAA	-			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:34671799_34671808delATGGAACCAA	uc010qej.1	-	9	1059_1068	c.1059_1068delTTGGTTCCAT	c.(1057-1068)ATTTGGTTCCATfs	p.I353fs	PARD3_uc010qek.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qel.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qem.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qen.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qeo.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qep.1_Frame_Shift_Del_p.I309fs|PARD3_uc010qeq.1_Frame_Shift_Del_p.I309fs|PARD3_uc001ixo.1_Frame_Shift_Del_p.I83fs|PARD3_uc001ixp.1_Frame_Shift_Del_p.I218fs|PARD3_uc001ixq.1_Frame_Shift_Del_p.I353fs|PARD3_uc001ixr.1_Frame_Shift_Del_p.I353fs|PARD3_uc001ixt.1_Frame_Shift_Del_p.I174fs|PARD3_uc001ixu.1_Frame_Shift_Del_p.I309fs|PARD3_uc001ixs.1_Frame_Shift_Del_p.I6fs	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	353_356	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CAGGAACCACATGGAACCAAATGATGGGTG	0.4		NA											36	96	---	---	---	---	NA	NA	NA	NA
CD163	9332	broad.mit.edu	37	12	7636068	7636069	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:7636068_7636069insA	uc001qsz.3	-	12	3110_3111	c.2982_2983insT	c.(2980-2985)AATGAAfs	p.N994fs	CD163_uc001qta.3_Frame_Shift_Ins_p.N994fs|CD163_uc009zfw.2_Frame_Shift_Ins_p.N1027fs	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	994_995	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CACTTCACTTCATTGAGCCATA	0.515		NA											25	48	---	---	---	---	NA	NA	NA	NA
KRT5	3852	broad.mit.edu	37	12	52911893	52911894	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:52911893_52911894insA	uc001san.2	-	3	987_988	c.824_825insT	c.(823-825)CTGfs	p.L275fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.L275fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	275	Rod.|Coil 1B.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCACCTTCTTCAGCATCACAAA	0.52		NA											93	158	---	---	---	---	NA	NA	NA	NA
GPR17	2840	broad.mit.edu	37	2	128409269	128409270	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:128409269_128409270insC	uc010yzn.1	+	4	1655_1656	c.1044_1045insC	c.(1042-1047)CCGCCCfs	p.P348fs	LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Frame_Shift_Ins_p.P348fs|GPR17_uc010yzo.1_Frame_Shift_Ins_p.P320fs|GPR17_uc002tpd.2_Frame_Shift_Ins_p.P320fs	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	348_349	Cytoplasmic (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TCAAGGGCCCGCCCCCCAGCTT	0.619		NA											34	65	---	---	---	---	NA	NA	NA	NA
SFRS15	57466	broad.mit.edu	37	21	33063194	33063194	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr21:33063194delA	uc002ypd.2	-	15	2227	c.1801delT	c.(1801-1803)TATfs	p.Y601fs	SFRS15_uc002ype.2_Frame_Shift_Del_p.Y601fs|SFRS15_uc010glu.2_Frame_Shift_Del_p.Y586fs|SFRS15_uc002ypf.1_Frame_Shift_Del_p.Y275fs	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	601						nucleus	nucleotide binding|RNA binding				0						CATGGAATATAAGTAACACCA	0.378		NA											25	73	---	---	---	---	NA	NA	NA	NA
TBC1D10A	83874	broad.mit.edu	37	22	30688485	30688498	+	Frame_Shift_Del	DEL	ACATGCTGTGGGGG	ACATGCTGTGGGGG	-	rs61730760	byFrequency	TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:30688485_30688498delACATGCTGTGGGGG	uc011akt.1	-	11	1417_1430	c.1393_1406delCCCCCACAGCATGT	c.(1393-1407)CCCCCACAGCATGTGfs	p.P465fs	GATSL3_uc003ahc.2_5'Flank|GATSL3_uc003ahe.2_5'Flank|GATSL3_uc003ahd.2_5'Flank|GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|GATSL3_uc010gvr.2_5'Flank|GATSL3_uc010gvs.2_5'Flank|TBC1D10A_uc003ahj.3_Frame_Shift_Del_p.P377fs|TBC1D10A_uc010gvu.2_Frame_Shift_Del_p.P472fs|TBC1D10A_uc003ahk.3_Frame_Shift_Del_p.P465fs	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	465_469						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CTTCGGGGGCACATGCTGTGGGGGACATGCATCT	0.636		NA											13	194	---	---	---	---	NA	NA	NA	NA