Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ACTRT2	140625	broad.mit.edu	37	1	2939015	2939015	+	Silent	SNP	G	G	A	rs145991951		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:2939015G>A	uc001ajz.2	+	1	970	c.765G>A	c.(763-765)CCG>CCA	p.P255P		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	255						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCGGGGACCCGCTGCACCAGG	0.657		NA											11	62					0	0	0	0
STX12	23673	broad.mit.edu	37	1	28144385	28144385	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:28144385G>A	uc001bou.3	+	7	725	c.600G>A	c.(598-600)CAG>CAA	p.Q200Q		NM_177424	NP_803173	Q86Y82	STX12_HUMAN	syntaxin 12	200	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		ATGTCAATCAGATATTTAAAG	0.333		NA											6	27					0	0	0	0
C8A	731	broad.mit.edu	37	1	57340684	57340684	+	Silent	SNP	C	C	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:57340684C>A	uc001cyo.2	+	3	366	c.234C>A	c.(232-234)ATC>ATA	p.I78I		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	78	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GTGGTGACATCTGGGATCAAG	0.488		NA											16	28					1.15e-07	1.49e-07	1	0
ZZZ3	26009	broad.mit.edu	37	1	78098454	78098454	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:78098454T>C	uc001dhq.2	-	5	1062	c.586A>G	c.(586-588)ATC>GTC	p.I196V	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.I196V|ZZZ3_uc001dhp.2_Missense_Mutation_p.I196V	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TAGCCTGTGATTTCTTCAACT	0.398		NA											9	94					0	0	0	0
NOTCH2	4853	broad.mit.edu	37	1	120512221	120512221	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:120512221C>A	uc001eik.2	-	6	1277	c.1021G>T	c.(1021-1023)GAT>TAT	p.D341Y	NOTCH2_uc001eil.2_Missense_Mutation_p.D341Y|NOTCH2_uc001eim.3_Missense_Mutation_p.D258Y	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	341	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGGCACAATCATCAATGTTC	0.562		NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				14	57					6.32e-08	8.24e-08	1	0
FLG	2312	broad.mit.edu	37	1	152282297	152282297	+	Missense_Mutation	SNP	C	C	G	rs139417173	by1000genomes	TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:152282297C>G	uc001ezu.1	-	3	5101	c.5065G>C	c.(5065-5067)GCA>CCA	p.A1689P		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1689	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTGTCTGCTGACTGCTGG	0.572		NA							Ichthyosis				156	410					0	0	0	0
FLAD1	80308	broad.mit.edu	37	1	154961254	154961254	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:154961254G>A	uc001fgf.1	+	2	1400	c.1046G>A	c.(1045-1047)GGA>GAA	p.G349E	FLAD1_uc001fgc.2_Missense_Mutation_p.G250E|FLAD1_uc001fgd.1_Missense_Mutation_p.G349E|FLAD1_uc001fge.1_Missense_Mutation_p.G252E|FLAD1_uc001fgg.1_Missense_Mutation_p.G252E|FLAD1_uc001fgh.1_Missense_Mutation_p.G82E	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	349					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTGCCCCAGGGATCGCTGGTC	0.562		NA											16	83					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171549100	171549100	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:171549100A>G	uc010pmg.1	+	28	7666	c.7400A>G	c.(7399-7401)TAT>TGT	p.Y2467C	BAT2L2_uc010pmh.1_Missense_Mutation_p.Y1379C|BAT2L2_uc010pmi.1_Missense_Mutation_p.Y304C|BAT2L2_uc010pmj.1_Translation_Start_Site	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	2467	Gln-rich.						protein C-terminus binding				0						CTTCAACCATATAGGTAAATG	0.448		NA											4	25					0	0	0	0
NEK2	4751	broad.mit.edu	37	1	211843718	211843718	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:211843718G>C	uc001hir.1	-	5	816	c.670C>G	c.(670-672)CTC>GTC	p.L224V	NEK2_uc001hiq.1_Missense_Mutation_p.L224V|NEK2_uc001his.3_Missense_Mutation_p.L224V|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	224	Protein kinase.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		TTCCCAGCGAGTTCTTTCTGG	0.343		NA											19	202					0	0	0	0
URB2	9816	broad.mit.edu	37	1	229794895	229794895	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:229794895C>T	uc001hts.1	+	10	4562	c.4426C>T	c.(4426-4428)CTC>TTC	p.L1476F	URB2_uc009xfd.1_Missense_Mutation_p.L1476F	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1476						nucleolus				central_nervous_system(2)|ovary(1)	3						GGGCATTTACCTCATCCTGGA	0.517		NA											54	127					0	0	0	0
SLC39A12	221074	broad.mit.edu	37	10	18289628	18289628	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr10:18289628C>T	uc001ipo.2	+	11	1906	c.1633C>T	c.(1633-1635)CTG>TTG	p.L545L	SLC39A12_uc001ipn.2_Silent_p.L508L|SLC39A12_uc001ipp.2_Silent_p.L544L|SLC39A12_uc010qck.1_Silent_p.L411L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	545	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AATCATGATTCTGGTTGGGGA	0.423		NA											21	58					0	0	0	0
OR52K1	390036	broad.mit.edu	37	11	4510853	4510853	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:4510853G>A	uc001lza.1	+	1	723	c.723G>A	c.(721-723)GGG>GGA	p.G241G		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		AGGCATTTGGGACATGTGTGT	0.537		NA											55	121					0	0	0	0
FNBP4	23360	broad.mit.edu	37	11	47741494	47741494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:47741494G>A	uc009ylv.2	-	16	3103	c.2950C>T	c.(2950-2952)CAG>TAG	p.Q984*	FNBP4_uc001ngi.2_Nonsense_Mutation_p.Q298*|FNBP4_uc001ngj.2_Nonsense_Mutation_p.Q891*	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	984										ovary(1)	1						ACCAGCTGCTGCTGTTTCCAC	0.443		NA											12	60					0	0	0	0
OR5T1	390155	broad.mit.edu	37	11	56043788	56043788	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:56043788T>C	uc001nio.1	+	1	674	c.674T>C	c.(673-675)ATT>ACT	p.I225T		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	225	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					ACTATCCTGATTGTCCTGATC	0.428		NA											58	131					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70319378	70319378	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:70319378C>G	uc001oqc.2	-	22	5224	c.5146G>C	c.(5146-5148)GAG>CAG	p.E1716Q	SHANK2_uc010rqn.1_Missense_Mutation_p.E1128Q|SHANK2_uc001opz.2_Missense_Mutation_p.E1121Q|uc009ysn.1_Intron|SHANK2_uc001opy.2_Missense_Mutation_p.E52Q	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1337					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGTTCATCTCTGTTGGCGAG	0.632		NA											26	420					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70332717	70332717	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:70332717C>A	uc001oqc.2	-	21	3759	c.3681G>T	c.(3679-3681)ATG>ATT	p.M1227I	SHANK2_uc010rqn.1_Missense_Mutation_p.M639I|SHANK2_uc001opz.2_Missense_Mutation_p.M632I|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	848					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAGACTCCTTCATGGCTCGGT	0.627		NA											25	506					3.01e-09	3.96e-09	1	0
OR10S1	219873	broad.mit.edu	37	11	123847523	123847523	+	Silent	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:123847523G>T	uc001pzm.1	-	1	876	c.876C>A	c.(874-876)ATC>ATA	p.I292I		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGGAGTTACGATTGTGTAGA	0.537		NA											33	76					2.5e-28	3.44e-28	1	0
ADAMTS8	11095	broad.mit.edu	37	11	130281312	130281312	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:130281312C>T	uc001qgg.3	-	6	2108	c.1750G>A	c.(1750-1752)GGG>AGG	p.G584R	ADAMTS8_uc001qgf.2_Missense_Mutation_p.G65R	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	584	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TGGTAATTACCGTCAGGGGGG	0.587		NA											13	30					0	0	0	0
OLR1	4973	broad.mit.edu	37	12	10313470	10313470	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:10313470G>A	uc001qxo.1	-	4	593	c.479C>T	c.(478-480)TCG>TTG	p.S160L	OLR1_uc010sgz.1_Intron|OLR1_uc010sha.1_Intron	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	160	Extracellular (Potential).|C-type lectin.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						AAATGAGCCCGAGGAAAATAG	0.428		NA											38	110					0	0	0	0
ITPR2	3709	broad.mit.edu	37	12	26808652	26808652	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:26808652G>A	uc001rhg.2	-	20	2995	c.2578C>T	c.(2578-2580)CTG>TTG	p.L860L		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	860	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCAAATGTCAGTTTATTTTTT	0.313		NA											20	58					0	0	0	0
SLC4A8	9498	broad.mit.edu	37	12	51883736	51883736	+	Splice_Site	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:51883736G>A	uc001rys.1	+	19	2878	c.2700_splice	c.e19+1	p.K900_splice	SLC4A8_uc001rym.2_Splice_Site_p.K847_splice|SLC4A8_uc001ryn.2_Splice_Site_p.K847_splice|SLC4A8_uc001ryo.2_Splice_Site_p.K847_splice|SLC4A8_uc010snj.1_Splice_Site_p.K927_splice|SLC4A8_uc001ryr.2_Splice_Site_p.K900_splice	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate						bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TATCTTAAAGGTAATCATCCT	0.269		NA											10	64					0	0	0	0
SMUG1	23583	broad.mit.edu	37	12	54576251	54576251	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:54576251G>T	uc001sff.1	-	4	571	c.442C>A	c.(442-444)CTC>ATC	p.L148I	SMUG1_uc001sfa.1_5'Flank|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Missense_Mutation_p.L148I|SMUG1_uc009znf.1_Missense_Mutation_p.L148I|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	148				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						TGTCCACAGAGGTTCCGGAAA	0.567		NA						BER_DNA_glycosylases					17	109					1.15e-07	1.49e-07	1	0
TSPAN19	144448	broad.mit.edu	37	12	85421708	85421708	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:85421708A>G	uc009zsj.2	-	4	334	c.233T>C	c.(232-234)ATT>ACT	p.I78T		NM_001100917	NP_001094387	P0C672	TSN19_HUMAN	tetraspanin 19	78	Helical; (Potential).					integral to membrane				ovary(1)	1						TTCGTTGTGAATTCCTATATA	0.299		NA											3	13					0	0	0	0
TXNRD1	7296	broad.mit.edu	37	12	104725379	104725379	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:104725379A>G	uc010swk.1	+	14	1632	c.1610A>G	c.(1609-1611)GAG>GGG	p.E537G	TXNRD1_uc010swl.1_Missense_Mutation_p.E387G|TXNRD1_uc010swm.1_Missense_Mutation_p.E439G|TXNRD1_uc010swn.1_Missense_Mutation_p.E387G|TXNRD1_uc010swo.1_Missense_Mutation_p.E387G|TXNRD1_uc010swp.1_Missense_Mutation_p.E349G|TXNRD1_uc010swq.1_Missense_Mutation_p.E437G|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.E453G	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	537					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GGCCTTTCTGAGGAGAAAGCT	0.333		NA											4	22					0	0	0	0
RFC5	5985	broad.mit.edu	37	12	118467588	118467588	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:118467588C>G	uc001twq.2	+	10	1009	c.884C>G	c.(883-885)TCT>TGT	p.S295C	RFC5_uc010syx.1_Missense_Mutation_p.S274C|RFC5_uc010syy.1_Missense_Mutation_p.S274C|RFC5_uc010syz.1_Missense_Mutation_p.S210C|RFC5_uc009zwr.2_Missense_Mutation_p.S292C	NM_007370	NP_031396	P40937	RFC5_HUMAN	replication factor C 5 isoform 1	295					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACTTTCCATCTTCAGTTCGA	0.373		NA											20	101					0	0	0	0
CLIP1	6249	broad.mit.edu	37	12	122839067	122839067	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:122839067G>A	uc001ucg.1	-	6	1346	c.1240C>T	c.(1240-1242)CGA>TGA	p.R414*	CLIP1_uc001uch.1_Nonsense_Mutation_p.R414*|CLIP1_uc001uci.1_Nonsense_Mutation_p.R414*|CLIP1_uc001ucj.1_Nonsense_Mutation_p.R115*|CLIP1_uc009zxo.1_Nonsense_Mutation_p.R5*|CLIP1_uc010tae.1_Nonsense_Mutation_p.R348*	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	414	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ACCATTGTTCGCAGCTGGTCC	0.507		NA											12	60					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32798468	32798468	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr13:32798468C>A	uc001utx.2	+	37	5358	c.4862C>A	c.(4861-4863)GCC>GAC	p.A1621D	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1621					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GGATGCTGGGCCCCCCTGGTT	0.572		NA											26	68					2.45e-14	3.32e-14	1	0
ING1	3621	broad.mit.edu	37	13	111371619	111371619	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr13:111371619C>T	uc001vri.2	+	2	1041	c.609C>T	c.(607-609)CGC>CGT	p.R203R	ING1_uc001vrf.2_Silent_p.R16R|ING1_uc001vrg.2_5'UTR|ING1_uc001vrh.2_Silent_p.R60R	NM_005537	NP_005528	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1 isoform D	203					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			ovary(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GCTTCAGTCGCGAGACAGACG	0.647		NA											13	91					0	0	0	0
DHRS7	51635	broad.mit.edu	37	14	60622827	60622827	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr14:60622827C>T	uc001xes.2	-	2	361	c.177G>A	c.(175-177)TCG>TCA	p.S59S	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Silent_p.S9S|DHRS7_uc001xeu.2_Silent_p.S59S	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	59	NAD (By similarity).						binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		CAATTCCACTCGAGGCTCCAG	0.448		NA											10	86					0	0	0	0
CILP	8483	broad.mit.edu	37	15	65490732	65490732	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:65490732T>C	uc002aon.2	-	9	2073	c.1892A>G	c.(1891-1893)AAT>AGT	p.N631S		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	631					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TGTGGAAATATTCCGGGGATC	0.517		NA											51	124					0	0	0	0
C15orf60	283677	broad.mit.edu	37	15	73766183	73766183	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:73766183C>G	uc002avq.2	+	2	198	c.170C>G	c.(169-171)TCC>TGC	p.S57C	C15orf60_uc010bjb.2_Missense_Mutation_p.S57C	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	57										pancreas(1)	1						GTTTTTGATTCCAATGAAGAA	0.323		NA											5	6					0	0	0	0
CSPG4	1464	broad.mit.edu	37	15	75981392	75981392	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:75981392G>A	uc002baw.2	-	3	2107	c.2014C>T	c.(2014-2016)CGA>TGA	p.R672*		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	672	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TGGGCCAGTCGCAACCCTGTG	0.672		NA											13	86					0	0	0	0
PEX11A	8800	broad.mit.edu	37	15	90226795	90226795	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:90226795C>T	uc002boi.2	-	3	652	c.557G>A	c.(556-558)CGA>CAA	p.R186Q	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	186	Lumenal (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTTCAGAGATCGGAATAAAAG	0.473		NA											40	232					0	0	0	0
USP31	57478	broad.mit.edu	37	16	23117561	23117561	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr16:23117561G>A	uc002dll.2	-	4	926	c.926C>T	c.(925-927)TCT>TTT	p.S309F		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	309					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		AATTGGCAAAGAAATGCAAAG	0.383		NA											6	42					0	0	0	0
CDYL2	124359	broad.mit.edu	37	16	80654799	80654799	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr16:80654799C>T	uc002ffs.2	-	4	973	c.868G>A	c.(868-870)GCA>ACA	p.A290T		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	290						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TCTGTGGCTGCGTTGCAGAGC	0.557		NA											9	40					0	0	0	0
PELP1	27043	broad.mit.edu	37	17	4594214	4594214	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:4594214G>C	uc002fyi.3	-	3	615	c.389C>G	c.(388-390)TCT>TGT	p.S130C	PELP1_uc010vsf.1_5'UTR	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	130					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CCGAAGCCAAGACACACAGTG	0.537		NA											12	53					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11572997	11572997	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:11572997T>G	uc002gne.2	+	17	3307	c.3239T>G	c.(3238-3240)GTG>GGG	p.V1080G	DNAH9_uc010coo.2_Missense_Mutation_p.V374G	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1080	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCCATCAAGGTGTTTGACGGC	0.468		NA											21	150					0	0	0	0
NF1	4763	broad.mit.edu	37	17	29586061	29586061	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:29586061T>A	uc002hgg.2	+	33	4677	c.4344T>A	c.(4342-4344)AGT>AGA	p.S1448R	NF1_uc002hgh.2_Missense_Mutation_p.S1427R|NF1_uc002hgi.1_Missense_Mutation_p.S460R	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1448	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(3)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TACTTCAGAGTATTGCCAATC	0.313		NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	14					0	0	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349724	30349724	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:30349724T>G	uc002hgu.2	+	1	1570	c.1559T>G	c.(1558-1560)ATA>AGA	p.I520R	LRRC37B_uc010wbx.1_Missense_Mutation_p.I438R|LRRC37B_uc010csu.2_Missense_Mutation_p.I520R	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	520	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AGCACCAACATATGTGAGCTC	0.537		NA											57	164					0	0	0	0
UBTF	7343	broad.mit.edu	37	17	42288993	42288993	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:42288993T>C	uc002igb.2	-	9	1095	c.1028A>G	c.(1027-1029)TAT>TGT	p.Y343C	UBTF_uc002igc.2_Missense_Mutation_p.Y306C|UBTF_uc010czs.2_Missense_Mutation_p.Y343C|UBTF_uc002igd.2_Missense_Mutation_p.Y306C|UBTF_uc010czt.2_Missense_Mutation_p.Y343C|UBTF_uc002ige.2_Missense_Mutation_p.Y306C	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	343	HMG box 3.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTTCTTGTGATAGGCGTCCTT	0.587		NA											31	134					0	0	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626341	44626341	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:44626341T>C	uc002ikn.1	+	9	3839	c.3836T>C	c.(3835-3837)ATT>ACT	p.I1279T	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Missense_Mutation_p.I240T|LRRC37A2_uc010dax.1_Missense_Mutation_p.I209T	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1279	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		ACCCACGCTATTTCCATTTTA	0.468		NA											18	96					0	0	0	0
AKAP1	8165	broad.mit.edu	37	17	55196358	55196358	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:55196358C>T	uc002iux.2	+	10	2821	c.2590C>T	c.(2590-2592)CCA>TCA	p.P864S	AKAP1_uc010wnl.1_Missense_Mutation_p.P864S|AKAP1_uc010dcm.2_Missense_Mutation_p.P864S	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	864					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					AAGTTACAGTCCAACTGGTCT	0.333		NA											70	261					0	0	0	0
FAM20A	54757	broad.mit.edu	37	17	66536060	66536060	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:66536060C>T	uc002jho.2	-	9	1555	c.1267G>A	c.(1267-1269)GAT>AAT	p.D423N	FAM20A_uc010wqp.1_Missense_Mutation_p.D285N|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.D134N	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	423						extracellular region					0	Breast(10;1.64e-13)					AGGAACCCATCATCCCCGAAC	0.567		NA											8	49					0	0	0	0
ABCA9	10350	broad.mit.edu	37	17	66978771	66978771	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:66978771A>G	uc002jhu.2	-	37	4795	c.4652T>C	c.(4651-4653)CTG>CCG	p.L1551P	ABCA9_uc010dez.2_Missense_Mutation_p.L1513P	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1551					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ATAGACCATCAGGGAGGAGAA	0.433		NA											3	106					0	0	0	0
SMCHD1	23347	broad.mit.edu	37	18	2673310	2673310	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:2673310C>G	uc002klm.3	+	4	644	c.455C>G	c.(454-456)TCA>TGA	p.S152*		NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	152					chromosome organization		ATP binding				0						ATTGACAATTCATTGTCTGCT	0.328		NA											8	22					0	0	0	0
CDH2	1000	broad.mit.edu	37	18	25532209	25532209	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:25532209T>G	uc002kwg.2	-	16	3088	c.2629A>C	c.(2629-2631)AGT>CGT	p.S877R	CDH2_uc010xbn.1_Missense_Mutation_p.S846R	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	877	Ser-rich.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCACCACTACTTGAGGAATTA	0.507		NA									OREG0003876	type=REGULATORY REGION|Gene=CDH2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	15	95					0	0	0	0
FAM59A	64762	broad.mit.edu	37	18	29867548	29867548	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:29867548C>T	uc002kxl.2	-	4	1068	c.1012G>A	c.(1012-1014)GAG>AAG	p.E338K	FAM59A_uc002kxk.1_Missense_Mutation_p.E338K	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	338										ovary(1)|skin(1)	2						CGTGAATACTCATCGATGTCG	0.547		NA											13	103					0	0	0	0
NOL4	8715	broad.mit.edu	37	18	31538215	31538215	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:31538215C>T	uc010dmi.2	-	7	1453	c.1224G>A	c.(1222-1224)CTG>CTA	p.L408L	NOL4_uc010xbs.1_Silent_p.L123L|NOL4_uc002kxr.3_Silent_p.L244L|NOL4_uc010xbt.1_Silent_p.L334L|NOL4_uc010dmh.2_Silent_p.L334L|NOL4_uc010xbu.1_Silent_p.L408L|NOL4_uc002kxt.3_Silent_p.L408L|NOL4_uc010xbv.1_Silent_p.L157L|NOL4_uc010xbw.1_Silent_p.L294L	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	408						nucleolus	RNA binding			ovary(3)	3						TAAAAGCTTTCAGCCGCTCGG	0.448		NA											40	85					0	0	0	0
MEX3D	399664	broad.mit.edu	37	19	1556787	1556788	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:1556787_1556788GC>TT	uc010dsn.2	-	2	730_731	c.730_731GC>AA	c.(730-732)GCC>AAC	p.A244N		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	244					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGTGTTCGGCCGCCGACAGG	0.688		NA											19	49					0	0	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841649	8841649	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:8841649C>T	uc010xkg.1	+	1	259	c.259C>T	c.(259-261)CGG>TGG	p.R87W		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						AGACTTTCTGCGGGGAGAAGG	0.552		NA											19	74					0	0	0	0
ANGPTL6	83854	broad.mit.edu	37	19	10203335	10203335	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:10203335C>G	uc002mmx.1	-	6	1461	c.1343G>C	c.(1342-1344)TGG>TCG	p.W448S	C19orf66_uc002mmu.3_3'UTR|C19orf66_uc002mmv.3_3'UTR|C19orf66_uc002mmw.3_3'UTR|ANGPTL6_uc002mmy.1_Missense_Mutation_p.W448S	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	448	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			AAACTCAGCCCAGTAGACACC	0.617		NA											28	83					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22157159	22157159	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:22157159T>C	uc002nqp.2	-	4	826	c.677A>G	c.(676-678)GAG>GGG	p.E226G	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTAGGGTTTCTCTCCAGTATG	0.358		NA											15	57					0	0	0	0
DPY19L3	147991	broad.mit.edu	37	19	32930743	32930743	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:32930743A>G	uc002ntg.2	+	8	958	c.782A>G	c.(781-783)AAT>AGT	p.N261S	DPY19L3_uc002nth.1_Missense_Mutation_p.N261S|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	261	Helical; (Potential).					integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TGGCAATTTAATCAATTTATG	0.388		NA											28	49					0	0	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56734095	56734095	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:56734095G>A	uc002qmq.2	-	4	770	c.604C>T	c.(604-606)CTA>TTA	p.L202L	ZSCAN5A_uc010ygi.1_Silent_p.L85L|ZSCAN5A_uc002qmr.2_Silent_p.L202L|ZSCAN5A_uc002qms.1_Silent_p.L202L	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	202					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CTCTTGTGTAGCAGAAAGTCC	0.488		NA											17	68					0	0	0	0
ABHD1	84696	broad.mit.edu	37	2	27352690	27352690	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:27352690C>T	uc002rit.2	+	6	846	c.686C>T	c.(685-687)TCT>TTT	p.S229F	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_RNA	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	229						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGACTCTGTCTGCATGCTGG	0.567		NA											16	81					0	0	0	0
THADA	63892	broad.mit.edu	37	2	43801884	43801884	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:43801884C>T	uc002rsw.3	-	11	1672	c.1320G>A	c.(1318-1320)TTG>TTA	p.L440L	THADA_uc002rsx.3_Silent_p.L440L|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Silent_p.L150L|THADA_uc002rta.2_Silent_p.L150L|THADA_uc002rtb.1_Silent_p.L440L|THADA_uc002rtc.3_Silent_p.L440L|THADA_uc002rtd.2_Silent_p.L440L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	440							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GACTCTCAGTCAATTCCACAA	0.418		NA											34	83					0	0	0	0
RANBP2	5903	broad.mit.edu	37	2	109382140	109382140	+	Silent	SNP	C	C	T	rs139290272	byFrequency	TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:109382140C>T	uc002tem.3	+	20	5271	c.5145C>T	c.(5143-5145)AGC>AGT	p.S1715S		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1715					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CTCCAAAGAGCGGATTTGAGG	0.428		NA											25	130					0	0	0	0
WDR33	55339	broad.mit.edu	37	2	128471233	128471233	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:128471233C>T	uc002tpg.1	-	18	3415	c.3232G>A	c.(3232-3234)GAA>AAA	p.E1078K		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1078					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CTGCGGCCTTCCCATGCCCCC	0.677		NA											33	128					0	0	0	0
ZEB2	9839	broad.mit.edu	37	2	145147391	145147391	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:145147391G>T	uc002tvu.2	-	10	3752	c.3272C>A	c.(3271-3273)GCG>GAG	p.A1091E	ZEB2_uc002tvv.2_Missense_Mutation_p.A1085E|ZEB2_uc010zbm.1_Missense_Mutation_p.A1062E|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1091	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTCGCGCTCCGCCGCTTCCCG	0.602		NA											17	91					5.01e-05	6.32e-05	1	0
TTN	7273	broad.mit.edu	37	2	179669322	179669322	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:179669322C>T	uc002und.2	-	2	273	c.48G>A	c.(46-48)GTG>GTA	p.V16V	TTN_uc010zfg.1_Silent_p.V16V|TTN_uc010zfh.1_Silent_p.V16V|TTN_uc010zfi.1_Silent_p.V16V|TTN_uc010zfj.1_Silent_p.V16V|TTN_uc002unb.2_Silent_p.V16V			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	16							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCAGTACCACAACGCTTT	0.438		NA											14	59					0	0	0	0
NRP2	8828	broad.mit.edu	37	2	206562314	206562314	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:206562314C>T	uc002vaw.2	+	2	911	c.120C>T	c.(118-120)ATC>ATT	p.I40I	NRP2_uc002vat.2_Silent_p.I40I|NRP2_uc002vau.2_Silent_p.I40I|NRP2_uc002vav.2_Silent_p.I40I|NRP2_uc002vax.2_Silent_p.I40I|NRP2_uc002vay.2_Silent_p.I40I|NRP2_uc010fud.2_Silent_p.I40I	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	40	Extracellular (Potential).|CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CTGGCTATATCACCTCTCCCG	0.498		NA											62	371					0	0	0	0
CUL3	8452	broad.mit.edu	37	2	225376090	225376090	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:225376090C>T	uc002vny.2	-	6	1248	c.864G>A	c.(862-864)TTG>TTA	p.L288L	CUL3_uc010zls.1_Silent_p.L222L|CUL3_uc010fwy.1_Silent_p.L294L	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	288					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TTCCATTTTTCAACATATGTA	0.338		NA											24	110					0	0	0	0
CUL3	8452	broad.mit.edu	37	2	225378279	225378279	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:225378279C>G	uc002vny.2	-	5	1000	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	CUL3_uc010zls.1_Missense_Mutation_p.E140Q|CUL3_uc010fwy.1_Missense_Mutation_p.E212Q	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	206					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AAAGGAGCCTCAAAATCTTCT	0.308		NA											5	24					0	0	0	0
C20orf30	29058	broad.mit.edu	37	20	5086842	5086842	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:5086842T>G	uc002wll.2	-	4	680	c.214A>C	c.(214-216)AGC>CGC	p.S72R	C20orf30_uc010gbi.2_Missense_Mutation_p.S72R|C20orf30_uc002wlk.2_Missense_Mutation_p.S135R|C20orf30_uc002wlm.2_Missense_Mutation_p.S72R|C20orf30_uc002wln.2_Missense_Mutation_p.S72R|C20orf30_uc002wlo.2_RNA	NM_001009924	NP_001009924	Q96A57	CT030_HUMAN	hypothetical protein LOC29058 isoform 2	72						integral to membrane					0						ACCCCTTTGCTGATGTAGCCT	0.388		NA											3	85					0	0	0	0
C20orf26	26074	broad.mit.edu	37	20	20054956	20054956	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:20054956C>G	uc002wru.2	+	4	381	c.305C>G	c.(304-306)ACG>AGG	p.T102R	C20orf26_uc010gcw.1_Missense_Mutation_p.T56R|C20orf26_uc010zse.1_Missense_Mutation_p.T102R|C20orf26_uc010zsf.1_Missense_Mutation_p.T102R	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	102										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCCCTGAATACGTTGTTCATG	0.512		NA											33	113					0	0	0	0
CST1	1469	broad.mit.edu	37	20	23731396	23731396	+	Missense_Mutation	SNP	G	G	T	rs143815991		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:23731396G>T	uc002wtp.2	-	1	179	c.108C>A	c.(106-108)AAC>AAA	p.N36K		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	36						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					TGAGGTCTGCGTTATAGATGC	0.572		NA											7	63					1.13e-05	1.44e-05	1	0
NEURL2	140825	broad.mit.edu	37	20	44519120	44519120	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:44519120G>C	uc002xqg.1	-	1	782	c.511C>G	c.(511-513)CTC>GTC	p.L171V	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	171	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				TGGTCCAAGAGATGGCTGTAG	0.657		NA									OREG0025985	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	77					0	0	0	0
CSE1L	1434	broad.mit.edu	37	20	47704564	47704564	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:47704564C>A	uc002xty.2	+	17	1876	c.1742C>A	c.(1741-1743)TCT>TAT	p.S581Y	CSE1L_uc010zyg.1_Missense_Mutation_p.S364Y|CSE1L_uc010ghx.2_Missense_Mutation_p.S525Y|CSE1L_uc010ghy.2_Missense_Mutation_p.S202Y|CSE1L_uc010zyh.1_Missense_Mutation_p.S230Y	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	581					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			AGAAGTTTTTCTCTCCTACAA	0.373		NA											11	27					2.81e-09	3.7e-09	1	0
CBLN4	140689	broad.mit.edu	37	20	54578941	54578941	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:54578941T>G	uc002xxa.2	-	1	1072	c.287A>C	c.(286-288)GAT>GCT	p.D96A		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	96	C1q.					cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			TCTGACCTGATCGAAGTAAAT	0.647		NA											30	192					0	0	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28307044	28307044	+	Missense_Mutation	SNP	C	C	A	rs142161826		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr21:28307044C>A	uc002ymg.2	-	4	2159	c.1430G>T	c.(1429-1431)CGA>CTA	p.R477L		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	477					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GATCTGCTTTCGTGGTAGGTC	0.507		NA											8	43					1.13e-05	1.44e-05	1	0
IFNAR2	3455	broad.mit.edu	37	21	34624976	34624976	+	Missense_Mutation	SNP	G	G	A	rs147789575	byFrequency	TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr21:34624976G>A	uc002yrd.2	+	7	878	c.550G>A	c.(550-552)GAA>AAA	p.E184K	IFNAR2_uc002yrb.2_Missense_Mutation_p.E184K|IFNAR2_uc002yrc.2_Missense_Mutation_p.E184K|IFNAR2_uc002yre.2_Missense_Mutation_p.E184K|IFNAR2_uc002yrf.2_Missense_Mutation_p.E184K|IFNAR2_uc002yrg.2_Missense_Mutation_p.E53K|IL10RB_uc002yrh.1_Missense_Mutation_p.E34K|IL10RB_uc002yri.1_5'UTR	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	184	Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GCATAAACCCGAAATAAAAGG	0.333		NA											12	25					0	0	0	0
PIK3IP1	113791	broad.mit.edu	37	22	31679217	31679217	+	Silent	SNP	T	T	A	rs145125391		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr22:31679217T>A	uc003akm.2	-	6	835	c.645A>T	c.(643-645)CGA>CGT	p.R215R	PIK3IP1_uc003akl.2_RNA|PIK3IP1_uc011alo.1_3'UTR|PIK3IP1_uc003akn.2_Silent_p.R195R	NM_052880	NP_443112	Q96FE7	P3IP1_HUMAN	HGFL protein isoform 1	215	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GCAGAGTGATTCGCTGCATCT	0.507		NA											15	71					0	0	0	0
LARGE	9215	broad.mit.edu	37	22	34157394	34157394	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr22:34157394T>C	uc003and.3	-	3	649	c.70A>G	c.(70-72)ATC>GTC	p.I24V	LARGE_uc003ane.3_Missense_Mutation_p.I24V|LARGE_uc010gwp.2_Missense_Mutation_p.I24V|LARGE_uc011ame.1_Intron|LARGE_uc011amf.1_Missense_Mutation_p.I24V	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	24	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				ATCCAGGTGATGGCTGGGATG	0.507		NA											24	100					0	0	0	0
PLXNB2	23654	broad.mit.edu	37	22	50727227	50727227	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr22:50727227C>T	uc003bkv.3	-	5	1431	c.1325G>A	c.(1324-1326)CGC>CAC	p.R442H		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	442	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TACCAGGTCGCGCTTGACTCT	0.607		NA											10	40					0	0	0	0
CNTN6	27255	broad.mit.edu	37	3	1367528	1367528	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:1367528A>T	uc003boz.2	+	9	1243	c.976A>T	c.(976-978)AAT>TAT	p.N326Y	CNTN6_uc011asj.1_Missense_Mutation_p.N254Y|CNTN6_uc003bpa.2_Missense_Mutation_p.N326Y	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	326	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GAAAATCCAAAATACACACCT	0.403		NA											11	40					0	0	0	0
CCR3	1232	broad.mit.edu	37	3	46307687	46307687	+	Silent	SNP	A	A	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:46307687A>T	uc003cpg.1	+	4	1581	c.1038A>T	c.(1036-1038)ACA>ACT	p.T346T	CCR3_uc003cpi.1_Silent_p.T346T|CCR3_uc003cpj.1_Silent_p.T346T|CCR3_uc003cpk.1_Silent_p.T367T|CCR3_uc010hjb.1_Silent_p.T364T|CCR3_uc003cpl.1_Silent_p.T379T	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	346	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTCCATCCACAGCAGAGCCGG	0.488		NA											14	28					0	0	0	0
TSC22D2	9819	broad.mit.edu	37	3	150128558	150128558	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:150128558G>A	uc003exv.2	+	1	1771	c.1421G>A	c.(1420-1422)GGG>GAG	p.G474E	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.G474E	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	474							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGTCCTGCCGGGGCTGGGCAG	0.726		NA											6	44					0	0	0	0
MED12L	116931	broad.mit.edu	37	3	151101967	151101967	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:151101967G>T	uc003eyp.2	+	33	4820	c.4782G>T	c.(4780-4782)GAG>GAT	p.E1594D	MED12L_uc011bnz.1_Missense_Mutation_p.E1454D|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.E757D	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1594					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GATCTGAAGAGAACAAGCGTG	0.378		NA											50	44					6.32e-29	8.74e-29	1	0
SI	6476	broad.mit.edu	37	3	164737435	164737435	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:164737435C>T	uc003fei.2	-	28	3440	c.3378G>A	c.(3376-3378)CTG>CTA	p.L1126L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1126	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TATTCCAGTTCAGATCTCGCT	0.433		NA								HNSCC(35;0.089)			38	158					0	0	0	0
SI	6476	broad.mit.edu	37	3	164777770	164777770	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:164777770G>T	uc003fei.2	-	10	1128	c.1066C>A	c.(1066-1068)CAA>AAA	p.Q356K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	356	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CGACTTAGTTGGAATCCAAGA	0.363		NA								HNSCC(35;0.089)			44	420					1.23e-20	1.68e-20	1	0
NAALADL2	254827	broad.mit.edu	37	3	175184818	175184818	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:175184818G>A	uc003fit.2	+	8	1466	c.1379G>A	c.(1378-1380)GGA>GAA	p.G460E	NAALADL2_uc003fiu.1_Missense_Mutation_p.G453E|NAALADL2_uc010hwy.1_Missense_Mutation_p.G234E|NAALADL2_uc010hwz.1_Missense_Mutation_p.G54E	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	460	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AGTTATAATGGACAAGAATGG	0.408		NA											7	555					0	0	0	0
ZNF639	51193	broad.mit.edu	37	3	179051488	179051488	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:179051488A>G	uc003fjq.1	+	6	1079	c.736A>G	c.(736-738)ATG>GTG	p.M246V	ZNF639_uc003fjr.1_Missense_Mutation_p.M246V	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	246	C2H2-type 2.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CTCTACCAATATGCTTCTGAT	0.368		NA											46	124					0	0	0	0
MFN1	55669	broad.mit.edu	37	3	179082965	179082965	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:179082965C>T	uc003fjs.2	+	7	831	c.705C>T	c.(703-705)CTC>CTT	p.L235L	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Silent_p.L263L|MFN1_uc010hxc.2_Silent_p.L88L	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	235	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TTTTCATTCTCAATAATCGTT	0.338		NA											10	164					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597		NA											4	13					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195511959	195511959	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:195511959G>A	uc011bto.1	-	2	6952	c.6492C>T	c.(6490-6492)ACC>ACT	p.T2164T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	45					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGTGTCGGTGACAGGAA	0.577		NA											3	13					0	0	0	0
UBA6	55236	broad.mit.edu	37	4	68499067	68499067	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:68499067T>C	uc003hdg.3	-	23	2190	c.2138A>G	c.(2137-2139)CAT>CGT	p.H713R		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	713					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						ACTTACCTTATGGTTAAAATA	0.303		NA											21	58					0	0	0	0
ODAM	54959	broad.mit.edu	37	4	71063726	71063726	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:71063726C>A	uc003hfc.2	+	4	244	c.227C>A	c.(226-228)TCT>TAT	p.S76Y		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	76	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						TCCCAGTTCTCTTTATCAGCT	0.478		NA											52	141					2.49e-17	3.4e-17	1	0
GRID2	2895	broad.mit.edu	37	4	94411922	94411922	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:94411922C>T	uc011cdt.1	+	12	2249	c.1991C>T	c.(1990-1992)TCC>TTC	p.S664F	GRID2_uc011cdu.1_Missense_Mutation_p.S569F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	664	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGAAAGTTCCATCCAGTAA	0.393		NA											13	45					0	0	0	0
USP53	54532	broad.mit.edu	37	4	120177469	120177469	+	Silent	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:120177469A>G	uc003ics.3	+	7	1507	c.441A>G	c.(439-441)AAA>AAG	p.K147K	USP53_uc003icr.3_Silent_p.K147K|USP53_uc003icu.3_5'UTR	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	147					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						GTACCTCTAAATCTTGTATCA	0.323		NA											5	8					0	0	0	0
ASB5	140458	broad.mit.edu	37	4	177143474	177143474	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:177143474G>C	uc003iuq.1	-	3	390	c.374C>G	c.(373-375)GCA>GGA	p.A125G	ASB5_uc003iup.1_Missense_Mutation_p.A72G	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	125	ANK 2.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ATTAGCTCCTGCTTCCAGCAG	0.418		NA											6	48					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187557927	187557927	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:187557927G>A	uc003izf.2	-	5	3972	c.3784C>T	c.(3784-3786)CGA>TGA	p.R1262*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1262	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTTCTTTCTCGGTCTGGCTTT	0.478		NA								HNSCC(5;0.00058)			119	168					0	0	0	0
MRPS30	10884	broad.mit.edu	37	5	44813292	44813292	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:44813292G>A	uc003joh.2	+	4	976	c.938G>A	c.(937-939)AGA>AAA	p.R313K		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	313					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					AGGCTTTTGAGACAAAACTGT	0.393		NA											4	42					0	0	0	0
RPS23	6228	broad.mit.edu	37	5	81571952	81571953	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:81571952_81571953GC>AT	uc003khu.2	-	4	500_501	c.407_408GC>AT	c.(406-408)GGC>GAT	p.G136D		NM_001025	NP_001016	P62266	RS23_HUMAN	ribosomal protein S23	136					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome				0		Lung NSC(167;0.0025)|all_lung(232;0.00278)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-42)|Epithelial(54;8.38e-37)|all cancers(79;1.42e-31)		TTTCCTTCTTGCCTTTGTATAG	0.381		NA											8	67					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263131	140263131	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:140263131C>T	uc003lif.2	+	1	1278	c.1278C>T	c.(1276-1278)ACC>ACT	p.T426T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.T426T|PCDHA13_uc003lid.2_Silent_p.T426T	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	426	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGTGACCGCGCGGGACG	0.657		NA											34	157					0	0	0	0
TCERG1	10915	broad.mit.edu	37	5	145836812	145836812	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:145836812G>A	uc003lob.2	+	3	392	c.352G>A	c.(352-354)GGA>AGA	p.G118R	TCERG1_uc003loc.2_Missense_Mutation_p.G118R|TCERG1_uc011dbt.1_Missense_Mutation_p.G118R	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	118	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTTCCACCAGGAATGCCTCC	0.453		NA											18	81					0	0	0	0
ADAM19	8728	broad.mit.edu	37	5	156934146	156934146	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:156934146C>T	uc003lwz.2	-	10	972	c.908G>A	c.(907-909)GGC>GAC	p.G303D	ADAM19_uc003lww.1_Missense_Mutation_p.G36D|ADAM19_uc011ddr.1_Missense_Mutation_p.G234D	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	303	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAAGGACATGCCCCTGCAGGA	0.622		NA											4	75					0	0	0	0
C5orf41	153222	broad.mit.edu	37	5	172517748	172517748	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:172517748A>G	uc003mch.2	+	4	870	c.566A>G	c.(565-567)AAG>AGG	p.K189R	C5orf41_uc003mcg.2_Missense_Mutation_p.K189R|C5orf41_uc003mcf.2_Missense_Mutation_p.K189R|C5orf41_uc011dfd.1_Missense_Mutation_p.K189R	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	189							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTTCTTCTAAGACTCTGCAG	0.438		NA											8	26					0	0	0	0
MAPK9	5601	broad.mit.edu	37	5	179669687	179669687	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:179669687G>T	uc003mls.3	-	8	1028	c.757C>A	c.(757-759)CAG>AAG	p.Q253K	MAPK9_uc003mlt.3_Missense_Mutation_p.Q253K|MAPK9_uc010jlc.2_Missense_Mutation_p.Q253K|MAPK9_uc003mlv.3_Missense_Mutation_p.Q253K	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	253	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGTTGGCTGAAGTTTCTTC	0.388		NA											5	46					1.24e-05	1.57e-05	1	0
DSP	1832	broad.mit.edu	37	6	7585963	7585963	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:7585963C>T	uc003mxp.1	+	24	8747	c.8468C>T	c.(8467-8469)CCG>CTG	p.P2823L	DSP_uc003mxq.1_Missense_Mutation_p.P2224L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2823	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCTTCGGCTCCGGGGtcccgc	0.428		NA											5	120					0	0	0	0
EEF1E1	9521	broad.mit.edu	37	6	8102741	8102742	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:8102741_8102742GC>AA	uc003mxz.2	-	1	87_88	c.13_14GC>TT	c.(13-15)GCA>TTA	p.A5L	EEF1E1_uc011dic.1_Missense_Mutation_p.A5L	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	5					negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)					CGACAACTCTGCGGCCGCCGCC	0.604		NA											6	47					0	0	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44217786	44217786	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:44217786G>A	uc003oxa.1	+	5	627	c.543G>A	c.(541-543)GTG>GTA	p.V181V	HSP90AB1_uc011dvr.1_Silent_p.V171V|HSP90AB1_uc003oxb.1_Silent_p.V181V|HSP90AB1_uc011dvs.1_Missense_Mutation_p.M1I|HSP90AB1_uc003oxc.1_5'UTR	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	181					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTACCAAAGTGATCCTCCATC	0.438		NA											23	78					0	0	0	0
CD2AP	23607	broad.mit.edu	37	6	47563619	47563619	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:47563619G>A	uc003oyw.2	+	12	1587	c.1131G>A	c.(1129-1131)CAG>CAA	p.Q377Q		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	377	Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			CACTGGAACAGAAACCTTCTA	0.353		NA											25	190					0	0	0	0
TFAP2B	7021	broad.mit.edu	37	6	50810853	50810853	+	Silent	SNP	G	G	A	rs140849621		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:50810853G>A	uc003pag.2	+	7	1297	c.1131G>A	c.(1129-1131)CCG>CCA	p.P377P		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	377				QLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTS GEGPGSKTGDKEEKHRK -> GNFVKNLRIYWRRTGHR (in Ref. 1; CAA71047).	nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					ACCGGACACCGATAGGGAACA	0.592		NA											60	142					0	0	0	0
TBL2	26608	broad.mit.edu	37	7	72987687	72987687	+	Silent	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:72987687G>A	uc003tyh.2	-	4	695	c.561C>T	c.(559-561)CAC>CAT	p.H187H	TBL2_uc011kex.1_Silent_p.H151H|TBL2_uc010lbg.2_Silent_p.H92H|TBL2_uc003tyi.2_Silent_p.H22H|TBL2_uc011key.1_Silent_p.H58H|TBL2_uc010lbh.2_Silent_p.H92H	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	187	WD 3.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				CAGGCGCCTTGTGCTTTTTAG	0.557		NA											28	134					0	0	0	0
STEAP4	79689	broad.mit.edu	37	7	87913481	87913481	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:87913481C>T	uc003ujs.2	-	2	209	c.104G>A	c.(103-105)GGA>GAA	p.G35E	STEAP4_uc010lek.2_Missense_Mutation_p.G35E|STEAP4_uc003ujt.2_Missense_Mutation_p.G35E	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	35					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CATTTTCAATCCCAGTGATCT	0.413		NA											10	100					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100484783	100484783	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:100484783G>A	uc003uwy.2	+	16	2205	c.1937G>A	c.(1936-1938)CGG>CAG	p.R646Q	SRRT_uc010lhl.1_Missense_Mutation_p.R645Q|SRRT_uc003uxa.2_Missense_Mutation_p.R645Q|SRRT_uc003uwz.2_Missense_Mutation_p.R646Q	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	646					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						ATCCACGTTCGGGGGCCCATG	0.602		NA											26	184					0	0	0	0
GPR37	2861	broad.mit.edu	37	7	124404598	124404598	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:124404598A>T	uc003vli.2	-	1	1084	c.433T>A	c.(433-435)TTC>ATC	p.F145I		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	145	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						ATCTGAAGGAAGAGCTGGAGG	0.627		NA											17	154					0	0	0	0
TRIM24	8805	broad.mit.edu	37	7	138239468	138239469	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:138239468_138239469GA>TT	uc003vuc.2	+	9	1502_1503	c.1287_1288GA>TT	c.(1285-1290)GAGAGC>GATTGC	p.429_430ES>DC	TRIM24_uc003vub.2_Missense_Mutation_p.429_430ES>DC	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	429_430					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						AGGATAAAGAGAGCCAGCCACA	0.371		NA											10	113					0	0	0	0
SORBS3	10174	broad.mit.edu	37	8	22429318	22429318	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:22429318C>T	uc003xbv.2	+	19	2171	c.1831C>T	c.(1831-1833)CAG>TAG	p.Q611*	SORBS3_uc003xbw.3_Nonsense_Mutation_p.Q269*	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	611					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		TAACACCTCTCAGATACACTG	0.607		NA											12	77					0	0	0	0
POTEA	340441	broad.mit.edu	37	8	43157231	43157231	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:43157231G>C	uc003xpz.1	+	5	854	c.811G>C	c.(811-813)GCA>CCA	p.A271P	POTEA_uc003xqa.1_Intron	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	271										ovary(1)	1						TGAAGATTATGCAGTTTCTAG	0.294		NA											14	52					0	0	0	0
SNX16	64089	broad.mit.edu	37	8	82713776	82713776	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:82713776C>T	uc011lft.1	-	9	1498	c.991G>A	c.(991-993)GAG>AAG	p.E331K	SNX16_uc003ycn.2_Missense_Mutation_p.E331K|SNX16_uc003yco.2_Missense_Mutation_p.E302K	NM_022133	NP_071416	P57768	SNX16_HUMAN	sorting nexin 16 isoform a	331					cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			ovary(1)|pancreas(1)	2						ACTTCTATCTCTGATACAGCA	0.353		NA											5	107					0	0	0	0
KCNV1	27012	broad.mit.edu	37	8	110980374	110980374	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:110980374C>T	uc003ynr.3	-	3	1788	c.1446G>A	c.(1444-1446)CTG>CTA	p.L482L	KCNV1_uc010mcw.2_Silent_p.L482L	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	482	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CTCTGCCTTTCAGTCGCAGCA	0.388		NA											10	35					0	0	0	0
SPTLC1	10558	broad.mit.edu	37	9	94794749	94794749	+	Nonstop_Mutation	SNP	A	A	G			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr9:94794749A>G	uc004arl.1	-	15	1458	c.1420T>C	c.(1420-1422)TAG>CAG	p.*474Q	SPTLC1_uc011ltv.1_Missense_Mutation_p.L463P	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	474						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GACTCTGCCTAGAGCAGGACG	0.582		NA											11	45					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898859	112898859	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr9:112898859C>T	uc004bei.2	+	9	1923	c.1731C>T	c.(1729-1731)CAC>CAT	p.H577H	PALM2-AKAP2_uc004bek.3_Silent_p.H345H|PALM2-AKAP2_uc004bej.3_Silent_p.H345H|PALM2-AKAP2_uc004bel.1_Silent_p.H155H|AKAP2_uc011lwi.1_Silent_p.H203H|AKAP2_uc004bem.2_Silent_p.H203H|PALM2-AKAP2_uc010mtw.1_Silent_p.H163H|AKAP2_uc011lwj.1_Silent_p.H114H|PALM2-AKAP2_uc004ben.2_Silent_p.H114H	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	114							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CACCTCCTCACATCGAGCTCA	0.622		NA											9	62					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139407980	139407980	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr9:139407980G>T	uc004chz.2	-	14	2217	c.2217C>A	c.(2215-2217)TGC>TGA	p.C739*	NOTCH1_uc004cia.1_5'UTR	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	739	Extracellular (Potential).|EGF-like 19; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCACAGTCGCACTTGTACC	0.612		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			16	9					3.41e-10	4.55e-10	1	0
TBX22	50945	broad.mit.edu	37	X	79286052	79286052	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chrX:79286052G>T	uc010nmg.1	+	9	1139	c.1005G>T	c.(1003-1005)TTG>TTT	p.L335F	TBX22_uc004edi.1_Missense_Mutation_p.L215F|TBX22_uc004edj.1_Missense_Mutation_p.L335F	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	335					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CCTCTCCTTTGAACTCCTTAC	0.473		NA											34	43					1.02e-06	1.32e-06	1	0
NXF5	55998	broad.mit.edu	37	X	101092616	101092616	+	Silent	SNP	C	C	T			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chrX:101092616C>T	uc011mrk.1	-	15	1290	c.930G>A	c.(928-930)AGG>AGA	p.R310R	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	310	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TTAGCAGCTTCCTCTGCAGGT	0.527		NA											5	72					0	0	0	0
CTTN	2017	broad.mit.edu	37	11	70275169	70275178	+	Frame_Shift_Del	DEL	CAAGTAACAT	CAAGTAACAT	-			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:70275169_70275178delCAAGTAACAT	uc001opv.3	+	14	1246_1255	c.1040_1049delCAAGTAACAT	c.(1039-1050)ACAAGTAACATCfs	p.T347fs	CTTN_uc001opu.2_Frame_Shift_Del_p.T310fs|CTTN_uc001opw.3_Frame_Shift_Del_p.T310fs|CTTN_uc010rqm.1_Frame_Shift_Del_p.T31fs|CTTN_uc001opx.2_Frame_Shift_Del_p.T31fs	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	347_350						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		ACCAGCAAAACAAGTAACATCAGAGCTAAC	0.567		NA											18	1368	---	---	---	---	NA	NA	NA	NA
FSD2	123722	broad.mit.edu	37	15	83434772	83434772	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:83434772delC	uc002bjd.2	-	10	1732	c.1565delG	c.(1564-1566)GGCfs	p.G522fs	FSD2_uc010uol.1_Frame_Shift_Del_p.G477fs|FSD2_uc010uom.1_Frame_Shift_Del_p.G477fs	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	522	Fibronectin type-III 2.									central_nervous_system(1)	1						GGTCGGGATGCCCACAACAGA	0.597		NA											2	4	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7577516	7577517	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:7577516_7577517insA	uc002gim.2	-	7	958_959	c.764_765insT	c.(763-765)ATCfs	p.I255fs	TP53_uc002gig.1_Frame_Shift_Ins_p.I255fs|TP53_uc002gih.2_Frame_Shift_Ins_p.I255fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.I123fs|TP53_uc010cng.1_Frame_Shift_Ins_p.I123fs|TP53_uc002gii.1_Frame_Shift_Ins_p.I123fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.I255fs|TP53_uc010cni.1_Frame_Shift_Ins_p.I255fs|TP53_uc002gij.2_Frame_Shift_Ins_p.I255fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Ins_p.I162fs|TP53_uc002gio.2_Frame_Shift_Ins_p.I123fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	255	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> T (in sporadic cancers; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> M (in sporadic cancers; somatic mutation).|I -> V (in sporadic cancers; somatic mutation).|I -> N (in sporadic cancers; somatic mutation).|I -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I255F(16)|p.0?(7)|p.I255del(7)|p.I255S(7)|p.I255N(7)|p.I255T(7)|p.I255fs*90(4)|p.I255fs*9(3)|p.I255V(3)|p.T253_I255del(2)|p.I255I(2)|p.I255fs*8(1)|p.?(1)|p.T256fs*8(1)|p.I254fs*7(1)|p.I255M(1)|p.R249_T256delRPILTIIT(1)|p.T256fs*17(1)|p.I254_T256del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTCCAGTGTGATGATGGTGAG	0.584		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	63	---	---	---	---	NA	NA	NA	NA
MFAP4	4239	broad.mit.edu	37	17	19290122	19290123	+	In_Frame_Ins	INS	-	-	AGC			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:19290122_19290123insAGC	uc002gvt.2	-	2	60_61	c.35_36insGCT	c.(34-36)CTT>CTGCTT	p.12_12L>LL	MFAP4_uc002gvr.2_RNA|MFAP4_uc002gvs.2_In_Frame_Ins_p.36_36L>LL	NM_002404	NP_002395	P55083	MFAP4_HUMAN	microfibrillar-associated protein 4 precursor	12					cell adhesion|signal transduction	microfibril	receptor binding				0	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GCGTGGAGAGAAGCAGCAGCAG	0.649		NA											3	5	---	---	---	---	NA	NA	NA	NA
ATR	545	broad.mit.edu	37	3	142176524	142176524	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:142176524delA	uc003eux.3	-	45	7699	c.7577delT	c.(7576-7578)ATGfs	p.M2526fs	ATR_uc003euy.1_Frame_Shift_Del_p.M412fs	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2526	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTCTGTTCCCATAGGACCCAT	0.388		NA						Other_conserved_DNA_damage_response_genes					10	108	---	---	---	---	NA	NA	NA	NA
SMC4	10051	broad.mit.edu	37	3	160150162	160150162	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:160150162delA	uc003fdh.2	+	22	3502	c.3389delA	c.(3388-3390)CAAfs	p.Q1130fs	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Frame_Shift_Del_p.Q1105fs|SMC4_uc003fdj.2_Frame_Shift_Del_p.Q1130fs|SMC4_uc010hwd.2_Frame_Shift_Del_p.Q1072fs|SMC4_uc003fdl.2_Frame_Shift_Del_p.Q833fs	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1130					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTTCGGAAACAAAGGCTTAAT	0.348		NA											29	55	---	---	---	---	NA	NA	NA	NA
SEMA5A	9037	broad.mit.edu	37	5	9054270	9054270	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:9054270delG	uc003jek.2	-	19	3330	c.2618delC	c.(2617-2619)CCGfs	p.P873fs		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	873	TSP type-1 6.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TCCATAGGCCGGGGCTGGATT	0.607		NA											10	66	---	---	---	---	NA	NA	NA	NA