Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MRPS15	64960	broad.mit.edu	37	1	36926866	36926866	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:36926866T>C	uc001cas.2	-	4	463	c.299A>G	c.(298-300)AAG>AGG	p.K100R		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	100					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCTGCTCACCTTGTTGGCCAT	0.393		NA											17	32					0	0	0	0
EPHA10	284656	broad.mit.edu	37	1	38187398	38187398	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:38187398C>T	uc009vvi.2	-	11	2166	c.2080G>A	c.(2080-2082)GAG>AAG	p.E694K	EPHA10_uc001cbt.2_5'Flank|EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	694	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTGAGGGCCTCGGCCAGGAAG	0.672		NA											5	24					0	0	0	0
RRAGC	64121	broad.mit.edu	37	1	39317431	39317431	+	Splice_Site	SNP	T	T	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:39317431T>C	uc001ccq.2	-	5	779	c.757_splice	c.e5-1	p.N253_splice	RRAGC_uc010oim.1_Splice_Site_p.N219_splice|RRAGC_uc001ccr.2_Splice_Site_p.N175_splice	NM_022157	NP_071440	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C						apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				ACCTGAATTCTTGGAAAAACA	0.323		NA											16	66					0	0	0	0
TMEM48	55706	broad.mit.edu	37	1	54269617	54269617	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:54269617G>C	uc001cvs.2	-	10	1291	c.1050C>G	c.(1048-1050)TTC>TTG	p.F350L	TMEM48_uc010onu.1_Missense_Mutation_p.F310L|TMEM48_uc001cvt.2_Missense_Mutation_p.F227L|TMEM48_uc009vzk.2_RNA|TMEM48_uc010onv.1_Missense_Mutation_p.F15L	NM_018087	NP_060557	Q9BTX1	NDC1_HUMAN	transmembrane protein 48	350	Cytoplasmic (Potential).				mRNA transport|nuclear pore complex assembly|nuclear pore distribution|protein transport|transmembrane transport	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore			ovary(1)|pancreas(1)	2						GGCTGAGGCTGAAAACTTCTT	0.308		NA											36	185					0	0	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510198	77510198	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:77510198C>T	uc001dhi.2	+	3	746	c.571C>T	c.(571-573)CTC>TTC	p.L191F	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	191	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						CAACCTGCATCTCCTGAGCCA	0.587		NA											27	187					0	0	0	0
CCDC18	343099	broad.mit.edu	37	1	93691976	93691976	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:93691976T>G	uc001dpq.2	+	17	2784	c.2616T>G	c.(2614-2616)TTT>TTG	p.F872L	CCDC18_uc009wdl.1_Missense_Mutation_p.F389L	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	753	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AGGAAAAGTTTGAAAAACAGT	0.294		NA											5	51					0	0	0	0
FCRLA	84824	broad.mit.edu	37	1	161681071	161681071	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:161681071G>C	uc001gbe.2	+	4	617	c.375G>C	c.(373-375)TGG>TGC	p.W125C	FCRLA_uc001gbd.2_Missense_Mutation_p.W119C|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	102	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GCCAGGCCTGGCAAGACTGGC	0.577		NA											6	49					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198713307	198713307	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:198713307C>T	uc001gur.1	+	26	2996	c.2816C>T	c.(2815-2817)CCG>CTG	p.P939L	PTPRC_uc001gus.1_Missense_Mutation_p.P891L|PTPRC_uc001gut.1_Missense_Mutation_p.P778L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	939	Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CCCAGTGAGCCGTCTCCACTA	0.294		NA											5	31					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240601464	240601464	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:240601464T>A	uc010pyd.1	+	16	5239	c.5014T>A	c.(5014-5016)TTT>ATT	p.F1672I	FMN2_uc010pye.1_Missense_Mutation_p.F1676I|FMN2_uc010pyg.1_Missense_Mutation_p.F268I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1672	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGCTCTGACTTTAAAGACTT	0.383		NA											15	117					0	0	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129300	248129300	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:248129300C>G	uc010pzd.1	+	1	667	c.667C>G	c.(667-669)CTA>GTA	p.L223V	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	223	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TATTATCTTGCTACTACCATT	0.448		NA											9	18					0	0	0	0
SPAG6	9576	broad.mit.edu	37	10	22690177	22690177	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:22690177C>G	uc001iri.2	+	9	1427	c.1285C>G	c.(1285-1287)CTG>GTG	p.L429V	SPAG6_uc001irj.2_Missense_Mutation_p.L429V|SPAG6_uc010qct.1_Missense_Mutation_p.L399V|SPAG6_uc009xkh.2_Missense_Mutation_p.L407V	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	429					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						TCCCAATATTCTGAAACATGT	0.348		NA											8	26					0	0	0	0
OPN4	94233	broad.mit.edu	37	10	88425489	88425489	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:88425489G>T	uc001kdq.2	+	10	1645	c.1418G>T	c.(1417-1419)AGC>ATC	p.S473I	LDB3_uc010qml.1_5'Flank|LDB3_uc010qmm.1_5'Flank|LDB3_uc001kdu.2_5'Flank|LDB3_uc001kdv.2_5'Flank|LDB3_uc009xsz.2_5'Flank|OPN4_uc001kdp.2_Missense_Mutation_p.S484I|OPN4_uc010qmk.1_Intron|LDB3_uc001kdr.2_5'Flank|LDB3_uc009xsy.2_5'Flank|LDB3_uc001kds.2_5'Flank|LDB3_uc001kdt.2_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	473	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CTGATCCCCAGCCAGGACCCC	0.577		NA											23	54					1.11e-09	1.32e-09	1	0
COX15	1355	broad.mit.edu	37	10	101474430	101474430	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:101474430G>C	uc001kqb.3	-	9	1764	c.1147C>G	c.(1147-1149)CTG>GTG	p.L383V	COX15_uc001kqc.3_Intron|COX15_uc010qpj.1_Missense_Mutation_p.L204V	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	383	Helical; (Potential).				heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		GTGGCGGCCAGAGGAGTTGGG	0.507		NA											12	84					0	0	0	0
SEC31B	25956	broad.mit.edu	37	10	102247522	102247522	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:102247522C>T	uc001krc.1	-	26	3493	c.3391G>A	c.(3391-3393)GAG>AAG	p.E1131K	SEC31B_uc010qpo.1_Missense_Mutation_p.E1130K|SEC31B_uc001krd.1_Missense_Mutation_p.E668K|SEC31B_uc001krf.1_Missense_Mutation_p.E564K|SEC31B_uc001kre.1_Missense_Mutation_p.E562K	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1131					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CGGGCAACCTCATGGAGCCCA	0.587		NA											4	31					0	0	0	0
OR8H1	219469	broad.mit.edu	37	11	56057964	56057964	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr11:56057964T>C	uc010rje.1	-	1	575	c.575A>G	c.(574-576)TAC>TGC	p.Y192C		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					TTCAATGTCGTATGTGTCCAT	0.443		NA											14	71					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49438545	49438545	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:49438545C>A	uc001rta.3	-	19	4945	c.4945G>T	c.(4945-4947)GAG>TAG	p.E1649*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1649					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGAGCAGCTCATCGGTGTCC	0.607		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			17	50					9.77e-05	0.000107738	1	0
TRHDE	29953	broad.mit.edu	37	12	72666978	72666978	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:72666978C>T	uc001sxa.2	+	1	450	c.420C>T	c.(418-420)CGC>CGT	p.R140R	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	140	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CGCAGCTGCGCCTGTCGGGCC	0.697		NA											5	25					0	0	0	0
CUX2	23316	broad.mit.edu	37	12	111758444	111758444	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:111758444G>A	uc001tsa.1	+	17	2784	c.2631G>A	c.(2629-2631)AAG>AAA	p.K877K		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	877						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCACCCTGAAGCCCACCGTGC	0.701		NA											4	12					0	0	0	0
TRAFD1	10906	broad.mit.edu	37	12	112578685	112578685	+	Silent	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:112578685C>G	uc001ttp.2	+	5	386	c.300C>G	c.(298-300)CTC>CTG	p.L100L	TRAFD1_uc001tto.2_Silent_p.L100L|TRAFD1_uc009zwb.2_Silent_p.L100L|TRAFD1_uc010syj.1_RNA	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	100	TRAF-type.				negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TTTCCATTCTCAAACTGAAGG	0.463		NA											22	73					0	0	0	0
P2RX7	5027	broad.mit.edu	37	12	121605311	121605311	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:121605311G>A	uc001tzm.2	+	8	861	c.765G>A	c.(763-765)GAG>GAA	p.E255E	P2RX7_uc001tzn.2_Silent_p.E165E|P2RX7_uc001tzo.2_Intron|P2RX7_uc001tzp.2_Intron|P2RX7_uc001tzq.2_Silent_p.E85E	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	255						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGGGCATTGAGATCTACTGGG	0.537		NA											16	80					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124268604	124268604	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:124268604C>T	uc001uft.3	+	8	952	c.927C>T	c.(925-927)ATC>ATT	p.I309I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	309	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGGATGTGATCAAGGAATCCG	0.463		NA											28	41					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124285882	124285882	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:124285882G>A	uc001uft.3	+	15	2188	c.2163G>A	c.(2161-2163)ACG>ACA	p.T721T	DNAH10_uc010tav.1_Silent_p.T263T|DNAH10_uc010taw.1_Silent_p.T206T	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	721	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCATAGGAACGTTAAACGATG	0.463		NA											69	164					0	0	0	0
PIWIL1	9271	broad.mit.edu	37	12	130827639	130827639	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:130827639G>A	uc001uik.2	+	3	273	c.183G>A	c.(181-183)AAG>AAA	p.K61K	PIWIL1_uc001uij.1_Silent_p.K61K	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	61					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAACAGCCAAGTCACAAGGTG	0.438		NA											9	14					0	0	0	0
ARL11	115761	broad.mit.edu	37	13	50204602	50204602	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr13:50204602A>G	uc001vdf.1	+	2	165	c.19A>G	c.(19-21)AGA>GGA	p.R7G		NM_138450	NP_612459	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	7					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		TGTGAATTCCAGAGGTCACAA	0.557		NA											13	106					0	0	0	0
LIG4	3981	broad.mit.edu	37	13	108861732	108861732	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr13:108861732T>A	uc001vqn.2	-	2	2158	c.1885A>T	c.(1885-1887)AAA>TAA	p.K629*	LIG4_uc001vqo.2_Nonsense_Mutation_p.K629*|LIG4_uc010agg.1_Nonsense_Mutation_p.K562*|LIG4_uc010agf.2_Nonsense_Mutation_p.K629*|LIG4_uc001vqp.2_Nonsense_Mutation_p.K629*	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	629					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					GGGGCAGCTTTCCGCTTTTTT	0.383		NA						NHEJ					22	51					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110829000	110829000	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr13:110829000C>G	uc001vqw.3	-	35	3063	c.2941G>C	c.(2941-2943)GGG>CGG	p.G981R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	981	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGCCTGCCCGTCCTTTCCA	0.577		NA											15	43					0	0	0	0
KIAA0247	9766	broad.mit.edu	37	14	70175519	70175519	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr14:70175519G>C	uc001xlk.2	+	5	900	c.584G>C	c.(583-585)AGA>ACA	p.R195T	KIAA0247_uc010aqz.2_Missense_Mutation_p.R170T	NM_014734	NP_055549	Q92537	K0247_HUMAN	hypothetical protein LOC9766 precursor	195	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		GCTGACCCCAGAGTACAGATT	0.592		NA											18	89					0	0	0	0
C14orf79	122616	broad.mit.edu	37	14	105457937	105457937	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr14:105457937G>A	uc001ypy.1	+	3	832	c.679G>A	c.(679-681)GGA>AGA	p.G227R	C14orf79_uc001ypz.1_RNA|C14orf79_uc010tym.1_RNA	NM_174891	NP_777551	Q96F83	CN079_HUMAN	hypothetical protein LOC122616	227											0		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00326)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0181)			TCTTGTTCTCGGAATAGATGC	0.562		NA											42	70					0	0	0	0
APBA2	321	broad.mit.edu	37	15	29390768	29390768	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:29390768G>T	uc001zck.2	+	8	1534	c.1327G>T	c.(1327-1329)GCA>TCA	p.A443S	APBA2_uc010azj.2_Missense_Mutation_p.A431S|APBA2_uc010uat.1_Missense_Mutation_p.A431S|APBA2_uc001zcl.2_Missense_Mutation_p.A431S|APBA2_uc001zcm.1_Missense_Mutation_p.A135S	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	443	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGTTTTAAATGCAGACACGCA	0.468		NA											7	50					0.00198382	0.00209747	1	0
ARHGAP11A	9824	broad.mit.edu	37	15	32921801	32921801	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:32921801C>T	uc001zgy.1	+	8	1665	c.943C>T	c.(943-945)CTA>TTA	p.L315L	ARHGAP11A_uc010ubw.1_Silent_p.L126L|ARHGAP11A_uc001zgw.2_Silent_p.L315L|ARHGAP11A_uc001zgx.2_Silent_p.L315L|ARHGAP11A_uc010ubx.1_Silent_p.L126L	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	315					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TTCAGCCCAGCTATCTGAATC	0.343		NA											9	84					0	0	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42439928	42439928	+	Silent	SNP	A	A	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:42439928A>C	uc001zoz.2	-	12	1155	c.1092T>G	c.(1090-1092)GGT>GGG	p.G364G	PLA2G4F_uc010bcq.2_5'Flank|PLA2G4F_uc001zoy.2_5'UTR|PLA2G4F_uc010bcr.2_Silent_p.G115G|PLA2G4F_uc001zpa.2_Silent_p.G115G|PLA2G4F_uc010bcs.2_Silent_p.G151G	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	364	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CTCGGGTTCCACCCCCGGAAC	0.522		NA											11	56					0	0	0	0
UBL7	84993	broad.mit.edu	37	15	74738533	74738533	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:74738533G>A	uc002axw.1	-	11	1203	c.1041C>T	c.(1039-1041)GAC>GAT	p.D347D	UBL7_uc002axx.1_Silent_p.D387D|UBL7_uc010bjr.1_Silent_p.D238D|UBL7_uc002axy.1_Silent_p.D347D|UBL7_uc002axz.1_Silent_p.D347D	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	347	UBA.						protein binding			ovary(1)	1						GGATGCCCATGTCACGTAGCT	0.602		NA											17	89					0	0	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85164982	85164982	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:85164982T>C	uc002bkr.2	+	3	1782	c.1556T>C	c.(1555-1557)GTG>GCG	p.V519A	ZSCAN2_uc010bmz.1_Missense_Mutation_p.V517A|ZSCAN2_uc010bna.2_Missense_Mutation_p.V369A|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	519	C2H2-type 11.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CAGCTCGTAGTGCACCAGCGG	0.592		NA											30	147					0	0	0	0
KLHL25	64410	broad.mit.edu	37	15	86312285	86312285	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:86312285C>T	uc002bly.2	-	2	960	c.757G>A	c.(757-759)GAG>AAG	p.E253K		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	253						cytoplasm				ovary(2)	2						AGGAGGGCCTCGCTGGAGACG	0.657		NA											8	23					0	0	0	0
TMEM8A	58986	broad.mit.edu	37	16	426289	426289	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:426289C>T	uc002cgu.3	-	6	1200	c.1071G>A	c.(1069-1071)ACG>ACA	p.T357T	TMEM8A_uc002cgv.3_Silent_p.T164T	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	357	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						TGTCCTCCCGCGTGACTGGGT	0.672		NA											31	74					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857175	9857175	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:9857175G>A	uc002czo.3	-	13	4774	c.4226C>T	c.(4225-4227)GCA>GTA	p.A1409V	GRIN2A_uc010uym.1_Missense_Mutation_p.A1409V|GRIN2A_uc010uyn.1_3'UTR|GRIN2A_uc002czr.3_3'UTR	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1409	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACAGTACGATGCCGTTGACCT	0.502		NA											19	41					0	0	0	0
CNGB1	1258	broad.mit.edu	37	16	57994804	57994804	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:57994804C>T	uc002emt.2	-	8	539	c.474G>A	c.(472-474)CTG>CTA	p.L158L	CNGB1_uc010cdh.2_Silent_p.L158L|CNGB1_uc002emu.2_Silent_p.L158L	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	158					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCACAGAAGCAGCCGCAGCC	0.622		NA											3	22					0	0	0	0
DPEP3	64180	broad.mit.edu	37	16	68011733	68011733	+	Splice_Site	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:68011733C>G	uc002evc.3	-	6	926	c.832_splice	c.e6-1	p.K278_splice	DPEP3_uc010cex.2_Splice_Site_p.K278_splice	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a						meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		CTACTACTTTCTGCAGAAACA	0.498		NA											3	24					0	0	0	0
HYDIN	54768	broad.mit.edu	37	16	70926425	70926425	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:70926425C>A	uc002ezr.2	-	56	9381	c.9253G>T	c.(9253-9255)GTG>TTG	p.V3085L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3086										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ACAGAGTCCACGGAAAAGCTG	0.453		NA											9	53					7.48e-07	8.53e-07	1	0
ITGAE	3682	broad.mit.edu	37	17	3661071	3661071	+	Missense_Mutation	SNP	C	C	G	rs143543471		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:3661071C>G	uc002fwo.3	-	9	1048	c.949G>C	c.(949-951)GAG>CAG	p.E317Q		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	317	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AGGGGGTCCTCGAATATGCCA	0.562		NA											33	239					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577498	7577498	+	Splice_Site	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:7577498C>T	uc002gim.2	-	7	976	c.782_splice	c.e7+1	p.S261_splice	TP53_uc002gig.1_Splice_Site_p.R261_splice|TP53_uc002gih.2_Splice_Site_p.S261_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.S129_splice|TP53_uc010cng.1_Splice_Site_p.S129_splice|TP53_uc002gii.1_Splice_Site_p.S129_splice|TP53_uc010cnh.1_Splice_Site_p.S261_splice|TP53_uc010cni.1_Splice_Site_p.S261_splice|TP53_uc002gij.2_Splice_Site_p.S261_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(25)|p.0?(7)|p.E258fs*71(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGCTCCTGACCTGGAGTCTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	30					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	rs121912651		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	44					0	0	0	0
ABCA6	23460	broad.mit.edu	37	17	67092867	67092867	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:67092867C>T	uc002jhw.1	-	24	3371	c.3196G>A	c.(3196-3198)GTC>ATC	p.V1066I		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1066	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AAGAAGCTGACGTCCACTAGT	0.353		NA											6	19					0	0	0	0
OTOP2	92736	broad.mit.edu	37	17	72927021	72927021	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:72927021G>T	uc010wrp.1	+	7	1380	c.1291G>T	c.(1291-1293)GGG>TGG	p.G431W		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	431						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					AGGACCGCCCGGGGCTGAGCC	0.622		NA											7	97					1.07e-07	1.24e-07	1	0
QRICH2	84074	broad.mit.edu	37	17	74287585	74287585	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:74287585G>A	uc002jrd.1	-	4	2905	c.2725C>T	c.(2725-2727)CAA>TAA	p.Q909*	QRICH2_uc010wsz.1_Nonsense_Mutation_p.Q835*|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	909							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						ACATGCTGTTGATCTGGGTGT	0.512		NA											14	122					0	0	0	0
CEP76	79959	broad.mit.edu	37	18	12697408	12697408	+	Splice_Site	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr18:12697408C>T	uc002kri.2	-	5	677	c.521_splice	c.e5-1	p.G174_splice	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_Splice_Site|CEP76_uc010wzz.1_Splice_Site_p.S99_splice|CEP76_uc010xaa.1_Splice_Site	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa						G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						GTTCCATCACCTAGCAATATA	0.299		NA											18	52					0	0	0	0
PRKACA	5566	broad.mit.edu	37	19	14211687	14211687	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:14211687C>T	uc002myc.2	-	5	570	c.370G>A	c.(370-372)GTG>ATG	p.V124M	PRKACA_uc002myb.2_Missense_Mutation_p.V116M|PRKACA_uc010xnm.1_Missense_Mutation_p.V66M|PRKACA_uc002myd.2_Missense_Mutation_p.V66M	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	124	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						CCGCCGGGCACGTACTCCATG	0.602		NA											11	52					0	0	0	0
IL12RB1	3594	broad.mit.edu	37	19	18194250	18194250	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:18194250G>A	uc002nhw.1	-	2	180	c.116C>T	c.(115-117)GCA>GTA	p.A39V	IL12RB1_uc010xqb.1_Missense_Mutation_p.A39V|IL12RB1_uc002nhx.1_Missense_Mutation_p.A79V|IL12RB1_uc002nhy.2_Missense_Mutation_p.A39V	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	39	Extracellular (Potential).				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						ACCTGAGTCTGCATCCGGATA	0.567		NA											4	107					0	0	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728189	20728189	+	Missense_Mutation	SNP	T	T	G	rs57947174	by1000genomes	TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:20728189T>G	uc002npa.2	-	4	1000	c.820A>C	c.(820-822)ACA>CCA	p.T274P		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	274					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						ATCTTATGTGTAGTAAGGTTA	0.398		NA											4	19					0	0	0	0
RYR1	6261	broad.mit.edu	37	19	39010003	39010003	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:39010003G>T	uc002oit.2	+	67	10298	c.10168G>T	c.(10168-10170)GGC>TGC	p.G3390C	RYR1_uc002oiu.2_Missense_Mutation_p.G3390C|RYR1_uc002oiv.1_Missense_Mutation_p.G310C|RYR1_uc010xuf.1_Missense_Mutation_p.G310C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3390					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCCCAGGAGGGCGAGCTGCT	0.662		NA											6	20					0.00116845	0.00124839	1	0
HNRNPUL1	11100	broad.mit.edu	37	19	41782195	41782195	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:41782195G>A	uc002oqb.3	+	5	1067	c.778G>A	c.(778-780)GAG>AAG	p.E260K	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.E160K|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.E160K|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.E260K|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.E217K|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.E160K|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.E160K|HNRNPUL1_uc010eho.2_Missense_Mutation_p.E160K|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.E160K|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.E116K|HNRNPUL1_uc010ehl.1_Missense_Mutation_p.E160K	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	260	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TGTATGCTTCGAGATGAAGGT	0.532		NA											12	88					0	0	0	0
PPFIA3	8541	broad.mit.edu	37	19	49631304	49631304	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:49631304G>A	uc002pmr.2	+	2	506	c.174G>A	c.(172-174)CTG>CTA	p.L58L	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_5'Flank|PPFIA3_uc010yaj.1_5'Flank|PPFIA3_uc002pms.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	58	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CAGCGCAGCTGCGGCTGCGCG	0.726		NA											10	13					0	0	0	0
NCOA1	8648	broad.mit.edu	37	2	24929930	24929930	+	Silent	SNP	C	C	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr2:24929930C>A	uc002rfk.2	+	11	1849	c.1591C>A	c.(1591-1593)CGA>AGA	p.R531R	NCOA1_uc010eye.2_Silent_p.R531R|NCOA1_uc002rfi.2_Silent_p.R380R|NCOA1_uc002rfj.2_Silent_p.R531R|NCOA1_uc002rfl.2_Silent_p.R531R	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	531	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAATAATAACCGATCTTATTC	0.443		NA	T	PAX3	alveolar rhadomyosarcoma								16	83					2.23e-06	2.5e-06	1	0
SPTBN1	6711	broad.mit.edu	37	2	54849492	54849492	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr2:54849492C>T	uc002rxu.2	+	9	1181	c.932C>T	c.(931-933)GCC>GTC	p.A311V	SPTBN1_uc002rxv.1_Missense_Mutation_p.A311V|SPTBN1_uc002rxx.2_Missense_Mutation_p.A298V	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	311	Spectrin 1.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GAATCACTTGCCTCTGACCTT	0.398		NA											10	91					0	0	0	0
RANBP2	5903	broad.mit.edu	37	2	109383270	109383270	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr2:109383270C>T	uc002tem.3	+	20	6401	c.6275C>T	c.(6274-6276)ACG>ATG	p.T2092M		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2092	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATAACGACTACGATGAACCTG	0.413		NA											62	360					0	0	0	0
OVOL2	58495	broad.mit.edu	37	20	18022341	18022341	+	Silent	SNP	C	C	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr20:18022341C>A	uc002wqi.1	-	3	591	c.348G>T	c.(346-348)TCG>TCT	p.S116S		NM_021220	NP_067043	Q9BRP0	OVOL2_HUMAN	zinc finger protein 339	116					negative regulation of keratinocyte differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription by competitive promoter binding|regulation of cell cycle|regulation of keratinocyte proliferation|transcription, DNA-dependent	nucleus	DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1						TGTGAACCACCGAGTCGCTGC	0.612		NA											10	28					0.000673444	0.000727176	1	0
LSS	4047	broad.mit.edu	37	21	47635094	47635094	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr21:47635094C>T	uc002zij.2	-	9	1090	c.1011G>A	c.(1009-1011)CCG>CCA	p.P337P	LSS_uc011afv.1_Silent_p.P326P|LSS_uc002zil.2_Silent_p.P337P|LSS_uc002zik.2_Silent_p.P257P	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	337					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GGGCACTGACCGGGCCGATGC	0.642		NA											7	67					0	0	0	0
PCNT	5116	broad.mit.edu	37	21	47863774	47863774	+	Missense_Mutation	SNP	C	C	G	rs138097697		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr21:47863774C>G	uc002zji.3	+	45	9859	c.9752C>G	c.(9751-9753)CCA>CGA	p.P3251R	PCNT_uc002zjj.2_Missense_Mutation_p.P3054R	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3251					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GAGTCCCCCCCAACCCGGGAT	0.592		NA											40	73					0	0	0	0
RFPL3	10738	broad.mit.edu	37	22	32756682	32756682	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr22:32756682G>A	uc003amj.2	+	2	1022	c.817G>A	c.(817-819)GTC>ATC	p.V273I	RFPL3_uc010gwn.2_Missense_Mutation_p.V244I|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	273	B30.2/SPRY.						zinc ion binding			ovary(1)	1						ATTCAGGAGCGTCTCTGCTGA	0.483		NA											14	47					0	0	0	0
ZNF80	7634	broad.mit.edu	37	3	113955725	113955725	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:113955725C>T	uc010hqo.2	-	1	701	c.197G>A	c.(196-198)CGA>CAA	p.R66Q	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	66	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CTGCTGATGTCGAACAAGGAG	0.488		NA											4	30					0	0	0	0
PLXND1	23129	broad.mit.edu	37	3	129278515	129278515	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:129278515C>T	uc003emx.2	-	32	5345	c.5245G>A	c.(5245-5247)GAG>AAG	p.E1749K	PLXND1_uc003emw.2_5'Flank|PLXND1_uc011blb.1_Missense_Mutation_p.E417K	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1749	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CCCCTCTTCTCAGCCTGCTCC	0.582		NA											41	133					0	0	0	0
LAMP3	27074	broad.mit.edu	37	3	182841888	182841888	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:182841888G>C	uc003flh.3	-	6	1456	c.1232C>G	c.(1231-1233)TCT>TGT	p.S411C		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	411	Cytoplasmic (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			CTGGTATCCAGATGATTGACA	0.453		NA											34	62					0	0	0	0
CPN2	1370	broad.mit.edu	37	3	194063384	194063384	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:194063384G>A	uc003fts.2	-	2	138	c.48C>T	c.(46-48)GCC>GCT	p.A16A		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	16					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GGGCAGGCCTGGCCAGGAGCA	0.592		NA											6	68					0	0	0	0
SLC26A1	10861	broad.mit.edu	37	4	982693	982693	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:982693G>A	uc003gcb.2	-	4	2412	c.2034C>T	c.(2032-2034)CTC>CTT	p.L678L	SLC26A1_uc003gbx.2_Intron|IDUA_uc003gby.2_Intron|IDUA_uc003gbz.2_Intron|IDUA_uc003gca.2_Intron|SLC26A1_uc003gcc.2_Silent_p.L678L	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	solute carrier family 26, member 1 isoform a	678	STAS.					integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGTGCACACTGAGGAACAGCT	0.672		NA											4	15					0	0	0	0
RGS12	6002	broad.mit.edu	37	4	3432594	3432594	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:3432594G>A	uc003ggw.2	+	17	4930	c.4026G>A	c.(4024-4026)CTG>CTA	p.L1342L	RGS12_uc003ggv.2_Silent_p.L1342L|RGS12_uc003ggy.1_3'UTR|RGS12_uc003ggz.2_Silent_p.L694L|RGS12_uc011bvs.1_3'UTR|RGS12_uc003gha.2_Silent_p.L684L|RGS12_uc010icv.2_Silent_p.L541L	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1342						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGCTGACCCTGATGGGGGAGG	0.672		NA											7	56					0	0	0	0
LIN54	132660	broad.mit.edu	37	4	83891502	83891502	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:83891502G>A	uc003hnx.3	-	4	1307	c.929C>T	c.(928-930)TCA>TTA	p.S310L	LIN54_uc003hnz.3_Missense_Mutation_p.S89L|LIN54_uc003hny.3_5'UTR|LIN54_uc010ijt.2_Intron|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Missense_Mutation_p.S89L	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	310					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				TTTCAAAGGTGAGATGGCTAT	0.333		NA											16	97					0	0	0	0
NFKB1	4790	broad.mit.edu	37	4	103527776	103527776	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:103527776G>A	uc011ceq.1	+	17	2340	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	NFKB1_uc011cep.1_Missense_Mutation_p.E626K|NFKB1_uc011cer.1_Missense_Mutation_p.E445K	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	625	Interaction with CFLAR.|ANK 3.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	AGCTGCCAAAGAAGGACATGA	0.502		NA											11	72					0	0	0	0
FAM149A	25854	broad.mit.edu	37	4	187088346	187088346	+	Silent	SNP	G	G	T	rs150961217		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:187088346G>T	uc003iyt.3	+	13	1884	c.1305G>T	c.(1303-1305)ACG>ACT	p.T435T	FAM149A_uc011cla.1_Silent_p.T435T|FAM149A_uc003iyu.3_Silent_p.T435T|FAM149A_uc010isl.2_Silent_p.T435T|FAM149A_uc011clb.1_Silent_p.T434T	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	726										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		AGTCGGATACGCCTCGAAAAA	0.368		NA											21	110					7.42e-09	8.76e-09	1	0
C5orf35	133383	broad.mit.edu	37	5	56212663	56212663	+	Silent	SNP	T	T	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:56212663T>G	uc003jqx.2	+	6	1207	c.834T>G	c.(832-834)CTT>CTG	p.L278L	C5orf35_uc003jqy.2_RNA	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	278										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		GTGTTGTTCTTGTCGCACTTA	0.333		NA											13	25					0	0	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59982801	59982801	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:59982801C>G	uc003jsh.2	-	2	375	c.302G>C	c.(301-303)CGT>CCT	p.R101P	DEPDC1B_uc011cqm.1_Missense_Mutation_p.R101P|DEPDC1B_uc011cqn.1_Missense_Mutation_p.R74P	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	101	DEP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				GTATAAGTGACGATTGTCTTC	0.428		NA											27	224					0	0	0	0
RAD17	5884	broad.mit.edu	37	5	68680680	68680680	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:68680680C>T	uc003jwo.2	+	5	660	c.598C>T	c.(598-600)CTA>TTA	p.L200L	RAD17_uc003jwg.2_Silent_p.L189L|RAD17_uc003jwh.2_Silent_p.L189L|RAD17_uc003jwi.2_Silent_p.L189L|RAD17_uc003jwj.2_Silent_p.L189L|RAD17_uc003jwk.2_Silent_p.L189L|RAD17_uc003jwl.2_Silent_p.L189L|RAD17_uc003jwm.2_Silent_p.L24L|RAD17_uc003jwn.2_Silent_p.L103L	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	200					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		CAAAGAGTTTCTACTAAGAGC	0.323		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					10	43					0	0	0	0
PBX2	5089	broad.mit.edu	37	6	32154198	32154198	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:32154198C>T	uc003oav.1	-	9	1525	c.1254G>A	c.(1252-1254)ACG>ACA	p.T418T	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	418							transcription factor binding			ovary(1)	1						CTGGTCCCTCCGTTGGGGATG	0.572		NA											3	32					0	0	0	0
BTNL2	56244	broad.mit.edu	37	6	32363864	32363864	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:32363864C>G	uc003obg.1	-	5	1030	c.1030G>C	c.(1030-1032)GAA>CAA	p.E344Q	BTNL2_uc010jty.1_Missense_Mutation_p.E67Q|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Missense_Mutation_p.E134Q	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	344	Extracellular (Potential).|Ig-like V-type 3.					integral to membrane				central_nervous_system(1)	1						TCATCTTTTTCAAAAAGGCAG	0.483		NA											7	79					0	0	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283477	33283477	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:33283477G>A	uc003oeb.2	-	2	1369	c.1217C>T	c.(1216-1218)TCC>TTC	p.S406F	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.S406F	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGGGGCATAGGAAGAGGGAGT	0.592		NA											33	212					0	0	0	0
SCUBE3	222663	broad.mit.edu	37	6	35213722	35213722	+	Silent	SNP	A	A	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:35213722A>G	uc003okf.1	+	20	2607	c.2601A>G	c.(2599-2601)TCA>TCG	p.S867S	SCUBE3_uc003okg.1_Silent_p.S866S|SCUBE3_uc003okh.1_Silent_p.S754S	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	867	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CCTTCCCAGCATCCCCATCCT	0.572		NA											87	208					0	0	0	0
KIF6	221458	broad.mit.edu	37	6	39387750	39387750	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:39387750C>G	uc003oot.2	-	15	1879	c.1784G>C	c.(1783-1785)AGT>ACT	p.S595T	KIF6_uc003oos.2_Missense_Mutation_p.S46T|KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Missense_Mutation_p.S386T|KIF6_uc011dua.1_Missense_Mutation_p.S595T|KIF6_uc010jxb.1_Missense_Mutation_p.S539T	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	595	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TTCATTTATACTTTCTCCCAG	0.358		NA											11	89					0	0	0	0
EFHC1	114327	broad.mit.edu	37	6	52303383	52303383	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:52303383C>T	uc003pap.3	+	3	782	c.567C>T	c.(565-567)TTC>TTT	p.F189F	EFHC1_uc011dwv.1_Silent_p.F98F|EFHC1_uc011dww.1_Silent_p.F170F	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	189	DM10 1.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					GTGACCAATTCACACAGGTAT	0.383		NA											8	86					0	0	0	0
ZNF292	23036	broad.mit.edu	37	6	87968682	87968682	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:87968682G>T	uc003plm.3	+	8	5376	c.5335G>T	c.(5335-5337)GGT>TGT	p.G1779C		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TGGATCTCAGGGTGCTGGTGA	0.323		NA											5	22					0.000602214	0.000653741	1	0
LACE1	246269	broad.mit.edu	37	6	108843529	108843529	+	Silent	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:108843529C>T	uc003psj.2	+	13	1533	c.1347C>T	c.(1345-1347)ACC>ACT	p.T449T		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	449							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		CCATGTTTACCGGAGAAGAGG	0.378		NA											11	73					0	0	0	0
CCDC28A	25901	broad.mit.edu	37	6	139101113	139101113	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:139101113C>A	uc003qie.2	+	3	738	c.583C>A	c.(583-585)CAA>AAA	p.Q195K		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	195											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TGGAAAACTTCAAGCATTTGG	0.393		NA											11	62					2.27e-07	2.6e-07	1	0
KATNA1	11104	broad.mit.edu	37	6	149919454	149919454	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:149919454A>C	uc003qmr.1	-	7	966	c.921T>G	c.(919-921)ATT>ATG	p.I307M	KATNA1_uc003qms.2_Missense_Mutation_p.I307M|KATNA1_uc003qmt.2_Missense_Mutation_p.I231M|KATNA1_uc011eed.1_Missense_Mutation_p.I231M	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	307					cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		CTATCTCATCAATAAATATGG	0.393		NA											20	59					0	0	0	0
SYNJ2	8871	broad.mit.edu	37	6	158483059	158483059	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:158483059G>A	uc003qqx.1	+	8	1065	c.990G>A	c.(988-990)ACG>ACA	p.T330T	SYNJ2_uc011efm.1_Intron|SYNJ2_uc003qqw.1_Silent_p.T330T|SYNJ2_uc003qqy.1_Silent_p.T43T|SYNJ2_uc011efn.1_Intron|SYNJ2_uc010kjo.1_Silent_p.T279T|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	330	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CGGGCGACACGCCTATGATCA	0.383		NA											40	286					0	0	0	0
PLG	5340	broad.mit.edu	37	6	161160163	161160163	+	Silent	SNP	G	G	A	rs61731712		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:161160163G>A	uc003qtm.3	+	16	2004	c.1941G>A	c.(1939-1941)CCG>CCA	p.P647P		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	647	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATCTCGAACCGCATGTTCAGG	0.478		NA											34	82					0	0	0	0
ALKBH4	54784	broad.mit.edu	37	7	102098318	102098318	+	Silent	SNP	C	C	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:102098318C>G	uc003uzl.2	-	3	437	c.432G>C	c.(430-432)GGG>GGC	p.G144G	ALKBH4_uc003uzm.2_Silent_p.G71G	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	144						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGCCCTCCAGCCCCGGGTAGA	0.667		NA											9	50					0	0	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144068318	144068318	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:144068318A>T	uc003wel.2	+	6	3714	c.3596A>T	c.(3595-3597)CAT>CTT	p.H1199L	ARHGEF5_uc003wek.2_Missense_Mutation_p.H1199L|ARHGEF5_uc003wem.2_Missense_Mutation_p.H54L	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1199	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					GCTGTGGATCATTTCCAACTT	0.488		NA											15	201					0	0	0	0
CUL1	8454	broad.mit.edu	37	7	148483659	148483659	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:148483659G>A	uc010lpg.2	+	12	1841	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	CUL1_uc003wey.2_Missense_Mutation_p.E439K|CUL1_uc003wez.2_Missense_Mutation_p.E329K|CUL1_uc003wfa.2_Missense_Mutation_p.E100K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	439					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GAACCCAGAGGAGGCAGAACT	0.378		NA											17	36					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616610	77616610	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr8:77616610T>G	uc003yav.2	+	2	674	c.287T>G	c.(286-288)ATG>AGG	p.M96R	ZFHX4_uc003yat.1_Missense_Mutation_p.M96R|ZFHX4_uc003yau.1_Missense_Mutation_p.M96R|ZFHX4_uc003yaw.1_Missense_Mutation_p.M96R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	96						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGAAATACATGGAACACCAC	0.502		NA								HNSCC(33;0.089)			66	125					0	0	0	0
PTP4A3	11156	broad.mit.edu	37	8	142441135	142441135	+	Silent	SNP	C	C	T	rs150126504	byFrequency	TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr8:142441135C>T	uc003ywg.1	+	5	847	c.513C>T	c.(511-513)TGC>TGT	p.C171C	PTP4A3_uc003ywh.1_Silent_p.C146C|PTP4A3_uc010met.1_Missense_Mutation_p.A85V	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	171						early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			CCCGGTGCTGCGTTATGTAGC	0.622		NA											16	84					0	0	0	0
DNAI1	27019	broad.mit.edu	37	9	34514718	34514718	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr9:34514718C>A	uc003zum.2	+	18	1992	c.1799C>A	c.(1798-1800)GCA>GAA	p.A600E		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	600	WD 4.				cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		GTGTTCGCAGCAGTCACCACA	0.567		NA							Kartagener_syndrome				24	93					1.66e-10	2.01e-10	1	0
SVEP1	79987	broad.mit.edu	37	9	113148250	113148250	+	Silent	SNP	G	G	A			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr9:113148250G>A	uc010mtz.2	-	43	10502	c.10165C>T	c.(10165-10167)CTG>TTG	p.L3389L	SVEP1_uc010mty.2_Silent_p.L1315L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3389	Sushi 33.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCCTGCAGCAGAAAACCTTCC	0.493		NA											4	50					0	0	0	0
PNPLA4	8228	broad.mit.edu	37	X	7868777	7868777	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chrX:7868777C>T	uc011mhq.1	-	7	874	c.712G>A	c.(712-714)GGT>AGT	p.G238S	PNPLA4_uc011mhr.1_Missense_Mutation_p.G238S|PNPLA4_uc011mhs.1_Missense_Mutation_p.G151S	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	238					lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				TCATCAAAACCACACTGATAC	0.343		NA											5	10					0	0	0	0
YY2	404281	broad.mit.edu	37	X	21875473	21875473	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chrX:21875473G>C	uc011mjp.1	+	1	871	c.871G>C	c.(871-873)GCT>CCT	p.A291P	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.A509P|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	291	Mediates transcriptional repression.|C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						ATGTGGCAAAGCTTTTCTTGA	0.537		NA											52	82					0	0	0	0
IGSF1	3547	broad.mit.edu	37	X	130409627	130409627	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chrX:130409627G>T	uc004ewd.2	-	16	3247	c.3009C>A	c.(3007-3009)CAC>CAA	p.H1003Q	IGSF1_uc004ewe.3_Missense_Mutation_p.H997Q|IGSF1_uc004ewf.2_Missense_Mutation_p.H983Q	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1003	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTCCTTCTTTGTGCAGAATGT	0.527		NA											8	34					5.69e-11	6.91e-11	1	0
CTNNA1	1495	broad.mit.edu	37	5	138145779	138145780	+	In_Frame_Ins	INS	-	-	GTG			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:138145779_138145780insGTG	uc003ldh.2	+	4	449_450	c.354_355insGTG	c.(352-357)insGTG	p.119_120insV	CTNNA1_uc011cyx.1_In_Frame_Ins_p.16_17insV|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_In_Frame_Ins_p.119_120insV	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	119_120	Interaction with JUP and CTNNB1.|Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCTGCTCTTCTGTGAAGCGAGG	0.455		NA											15	84	---	---	---	---	NA	NA	NA	NA