Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF2	65122	broad.mit.edu	37	1	12920063	12920063	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:12920063A>G	uc001aum.1	+	3	890	c.803A>G	c.(802-804)CAC>CGC	p.H268R		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	268											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCTGGAACACCTCCAGTTG	0.463		NA											17	74					0	0	0	0
NBPF1	55672	broad.mit.edu	37	1	16907242	16907243	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:16907242_16907243GG>TT	uc009vos.1	-	16	2476_2477	c.1588_1589CC>AA	c.(1588-1590)CCA>AAA	p.P530K	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Missense_Mutation_p.P259K	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	530	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GAGGCTACCTGGGAGAATGTTT	0.421		NA											20	645					0	0	0	0
PADI2	11240	broad.mit.edu	37	1	17422438	17422438	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:17422438C>G	uc001baf.2	-	4	459	c.377G>C	c.(376-378)CGG>CCG	p.R126P	PADI2_uc010ocm.1_Missense_Mutation_p.R126P|PADI2_uc001bag.1_Missense_Mutation_p.R126P	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	126					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CACACCATCCCGGTCTGCGTC	0.612		NA											3	50					0	0	0	0
SFRS4	6429	broad.mit.edu	37	1	29475099	29475099	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:29475099G>T	uc001bro.2	-	6	1681	c.1308C>A	c.(1306-1308)ACC>ACA	p.T436T	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	436	Arg/Ser-rich (RS domain).			TNQ -> RNE (in Ref. 1; AAA36649).	mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		TCTCCTGATTGGTGCCAGCAT	0.522		NA											9	134					4.69e-08	1.04e-06	1	0
COL16A1	1307	broad.mit.edu	37	1	32165642	32165642	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:32165642C>T	uc001btk.1	-	3	513	c.148G>A	c.(148-150)GGC>AGC	p.G50S	COL16A1_uc001btj.1_5'Flank|COL16A1_uc001btl.3_Missense_Mutation_p.G50S	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	50	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGTGCTCACCAGTCACGTTG	0.572		NA											11	21					0	0	0	0
SPOCD1	90853	broad.mit.edu	37	1	32264059	32264059	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:32264059C>T	uc001bts.1	-	8	2070	c.2012G>A	c.(2011-2013)CGG>CAG	p.R671Q	SPOCD1_uc001btt.2_5'UTR|SPOCD1_uc001btu.2_Missense_Mutation_p.R671Q|SPOCD1_uc001btv.2_Missense_Mutation_p.R164Q|SPOCD1_uc001btw.1_5'UTR	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	671	TFIIS central.		R -> W (in a breast cancer sample; somatic mutation).		transcription, DNA-dependent			p.R671W(1)		ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCTGGGGTCCCGCAGGTTGAA	0.617		NA											12	21					0	0	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47564902	47564902	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:47564902A>G	uc001cqu.1	+	8	1016	c.1013A>G	c.(1012-1014)CAG>CGG	p.Q338R		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	338	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						GAGCATCAGCAGAGATGCCGA	0.458		NA											3	35					0	0	0	0
MCOLN2	255231	broad.mit.edu	37	1	85395292	85395292	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:85395292T>A	uc001dkm.2	-	13	1854	c.1613A>T	c.(1612-1614)GAG>GTG	p.E538V	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	538						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TTTCTGATACTCTTCTTTGCT	0.438		NA											5	20					0	0	0	0
CCBL2	56267	broad.mit.edu	37	1	89426943	89426943	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:89426943T>C	uc001dmp.2	-	8	1071	c.694A>G	c.(694-696)ATT>GTT	p.I232V	CCBL2_uc001dmq.2_Missense_Mutation_p.I198V|CCBL2_uc001dmr.2_Missense_Mutation_p.I68V	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	232					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGGTCAGCAATTACTTGCAGT	0.363		NA											17	85					0	0	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454676	114454676	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:114454676A>G	uc001eeg.2	+	4	1633	c.1462A>G	c.(1462-1464)AAG>GAG	p.K488E	DCLRE1B_uc001eeh.2_Intron|DCLRE1B_uc001eei.2_Missense_Mutation_p.K362E	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	488					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCACAGCAGCAAGGGCACCCC	0.532		NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					11	30					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NA											5	26					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152277266	152277266	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:152277266G>C	uc001ezu.1	-	3	10132	c.10096C>G	c.(10096-10098)CAG>GAG	p.Q3366E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3366	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTGGCTCTGCTGATGGGGC	0.582		NA							Ichthyosis				25	177					0	0	0	0
LCE1C	353133	broad.mit.edu	37	1	152777761	152777761	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:152777761C>A	uc001fap.1	-	2	245	c.194G>T	c.(193-195)GGG>GTG	p.G65V		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	65	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGCATCCCCCAGAGCTGGA	0.617		NA											7	42					2.01e-06	4.26e-05	1	0
FAM5B	57795	broad.mit.edu	37	1	177250578	177250578	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:177250578G>T	uc001glf.2	+	8	2578	c.2266G>T	c.(2266-2268)GTG>TTG	p.V756L	FAM5B_uc001glg.2_Missense_Mutation_p.V651L	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	756						extracellular region		p.V756M(1)		skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CAACAATGAGGTGGGCAGGAT	0.557		NA											5	42					1.02e-07	2.26e-06	1	0
RGL1	23179	broad.mit.edu	37	1	183895366	183895366	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:183895366G>A	uc001gqo.2	+	18	2404	c.2247G>A	c.(2245-2247)ACG>ACA	p.T749T	RGL1_uc001gqm.2_Silent_p.T784T|RGL1_uc010pog.1_Silent_p.T747T|RGL1_uc010poh.1_Silent_p.T747T|RGL1_uc010poi.1_Silent_p.T720T	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	749					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CCAGCTTGACGTTGCCCAGGA	0.502		NA											23	32					0	0	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186839595	186839595	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:186839595C>T	uc001gsc.2	+	3	267	c.62C>T	c.(61-63)ACG>ATG	p.T21M	PLA2G4A_uc010pos.1_Missense_Mutation_p.T21M	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	21	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CACAAGTTTACGGTAGTGGTG	0.383		NA											9	29					0	0	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186915840	186915840	+	Nonsense_Mutation	SNP	G	G	T	rs77939449		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:186915840G>T	uc001gsc.2	+	11	1310	c.1105G>T	c.(1105-1107)GGA>TGA	p.G369*	PLA2G4A_uc010pos.1_Nonsense_Mutation_p.G309*	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	369	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CGACTTATTTGGAAGCAAATT	0.328		NA											10	101					9.31e-06	0.00019321	1	0
CRB1	23418	broad.mit.edu	37	1	197316484	197316484	+	Missense_Mutation	SNP	G	G	A	rs148240351		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:197316484G>A	uc001gtz.2	+	4	998	c.863G>A	c.(862-864)TGC>TAC	p.C288Y	CRB1_uc010poz.1_Missense_Mutation_p.C219Y|CRB1_uc001gty.1_Missense_Mutation_p.C288Y|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Intron|CRB1_uc010ppb.1_Missense_Mutation_p.C288Y|CRB1_uc010ppc.1_RNA	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	288	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGCTGTAACTGCACGGGTAGT	0.388		NA											18	131					0	0	0	0
WDR26	80232	broad.mit.edu	37	1	224607315	224607315	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:224607315T>C	uc001hop.3	-	5	692	c.326A>G	c.(325-327)TAT>TGT	p.Y109C	WDR26_uc001hoq.3_Missense_Mutation_p.Y93C|WDR26_uc009xei.1_Missense_Mutation_p.Y93C	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	256						cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		ACACATCAGATACCTAAAAAT	0.378		NA											37	33					0	0	0	0
ARID4B	51742	broad.mit.edu	37	1	235346105	235346105	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:235346105G>A	uc001hwq.2	-	20	2627	c.2129C>T	c.(2128-2130)TCT>TTT	p.S710F	ARID4B_uc001hwr.2_Missense_Mutation_p.S624F|ARID4B_uc001hws.3_Missense_Mutation_p.S624F|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.S391F	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			AGAACTTTCAGAAGCTAGAAA	0.373		NA											16	71					0	0	0	0
ADSS	159	broad.mit.edu	37	1	244574694	244574694	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:244574694G>T	uc001iaj.2	-	12	1507	c.1213C>A	c.(1213-1215)CTC>ATC	p.L405I		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	405					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CATCCTGGGAGAGTCTTATAT	0.343		NA											20	133					1.28e-07	2.79e-06	1	0
OR11L1	391189	broad.mit.edu	37	1	248004731	248004731	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248004731G>A	uc001idn.1	-	1	468	c.468C>T	c.(466-468)GGC>GGT	p.G156G		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGCAGAAAGCCTGTGCTGA	0.577		NA											11	48					0	0	0	0
OR2M5	127059	broad.mit.edu	37	1	248308964	248308965	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248308964_248308965GG>TT	uc010pze.1	+	1	515_516	c.515_516GG>TT	c.(514-516)CGG>CTT	p.R172L		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TGTGGGTCTCGGGAAATAGCCC	0.426		NA											13	191					0	0	0	0
OR2T4	127074	broad.mit.edu	37	1	248525876	248525876	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248525876G>C	uc001ieh.1	+	1	994	c.994G>C	c.(994-996)GCT>CCT	p.A332P		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	332	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTCATGGGGGCTCTGAAGAA	0.413		NA											25	109					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16870832	16870832	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:16870832G>A	uc001ioo.2	-	66	10788	c.10736C>T	c.(10735-10737)TCT>TTT	p.S3579F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3579	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAGGATGGAGAGCTGGCGTT	0.433		NA									OREG0020047	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	37					0	0	0	0
FRMPD2	143162	broad.mit.edu	37	10	49409355	49409355	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:49409355T>A	uc001jgi.2	-	15	1977	c.1870A>T	c.(1870-1872)AGT>TGT	p.S624C	FRMPD2_uc001jgh.2_Missense_Mutation_p.S592C|FRMPD2_uc001jgj.2_Missense_Mutation_p.S602C	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	624	FERM.			S -> G (in Ref. 3; CAH18097).	tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		AAGTATTTACTGGTCTTGGCT	0.448		NA											9	73					0	0	0	0
SORCS1	114815	broad.mit.edu	37	10	108469071	108469072	+	Missense_Mutation	DNP	CT	CT	AG			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:108469071_108469072CT>AG	uc001kym.2	-	7	1060_1061	c.1052_1053AG>CT	c.(1051-1053)CAG>CCT	p.Q351P	SORCS1_uc001kyl.2_Missense_Mutation_p.Q351P|SORCS1_uc009xxs.2_Missense_Mutation_p.Q351P|SORCS1_uc001kyn.1_Missense_Mutation_p.Q351P|SORCS1_uc001kyo.2_Missense_Mutation_p.Q351P	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	351	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTGTACAGTTCTGCATTCGGCA	0.386		NA											16	56					0	0	0	0
TIAL1	7073	broad.mit.edu	37	10	121336173	121336173	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:121336173C>T	uc001lei.1	-	11	1515	c.951G>A	c.(949-951)CCG>CCA	p.P317P	TIAL1_uc001leh.1_Silent_p.P295P|TIAL1_uc001lej.1_Silent_p.P334P|TIAL1_uc001lek.1_Silent_p.P194P|TIAL1_uc009xzi.1_Silent_p.P186P|TIAL1_uc010qtb.1_3'UTR	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1	317					apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		CTCCATAAGGCGGTACTTGCC	0.428		NA											26	103					0	0	0	0
NUP98	4928	broad.mit.edu	37	11	3726504	3726504	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:3726504G>A	uc001lyh.2	-	22	3299	c.3008C>T	c.(3007-3009)GCA>GTA	p.A1003V	NUP98_uc001lyi.2_Missense_Mutation_p.A1003V|NUP98_uc001lyg.2_Missense_Mutation_p.A71V	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1020					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGAAGTATCTGCTTTGGAAGG	0.413		NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								26	62					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22279232	22279232	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:22279232G>A	uc001mqi.2	+	14	1656	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	ANO5_uc001mqj.2_Missense_Mutation_p.E446K	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	447	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ACAGGAGATGGAACCTTACAT	0.378		NA											26	39					0	0	0	0
OR5B12	390191	broad.mit.edu	37	11	58206944	58206944	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:58206944G>C	uc010rkh.1	-	1	681	c.681C>G	c.(679-681)CGC>CGG	p.R227R		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTCAGGTGAGCGCATCTTCA	0.398		NA											3	45					0	0	0	0
OR4D11	219986	broad.mit.edu	37	11	59271552	59271552	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:59271552C>A	uc001noa.1	+	1	504	c.504C>A	c.(502-504)TTC>TTA	p.F168L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCTCCCTTTCTGTGGACCCA	0.512		NA											19	80					1.4e-16	3.22e-15	1	0
AHNAK	79026	broad.mit.edu	37	11	62297926	62297926	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:62297926G>T	uc001ntl.2	-	5	4263	c.3963C>A	c.(3961-3963)CCC>CCA	p.P1321P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1321					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGAGATCTTGGGGGCCTTGA	0.517		NA											33	80					1.03e-13	2.37e-12	1	0
MACROD1	28992	broad.mit.edu	37	11	63919857	63919857	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:63919857T>G	uc001nyh.2	-	2	426	c.307A>C	c.(307-309)AAG>CAG	p.K103Q		NM_014067	NP_054786	Q9BQ69	MACD1_HUMAN	MACRO domain containing 1	103											0						CTCAGGCCCTTCAGAAAGGCT	0.567		NA											13	47					0	0	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810581	65810581	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:65810581C>T	uc001ogv.2	-	2	853	c.693G>A	c.(691-693)GTG>GTA	p.V231V	GAL3ST3_uc001ogw.2_Silent_p.V231V	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	231	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						AAACCTCCTCCACCTGGCGGA	0.662		NA											6	27					0	0	0	0
DHCR7	1717	broad.mit.edu	37	11	71146483	71146483	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:71146483C>T	uc001oqk.2	-	9	1616	c.1366G>A	c.(1366-1368)GGC>AGC	p.G456S	DHCR7_uc001oql.2_Missense_Mutation_p.G456S	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	456					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	CAGTCCCGGCCGTACTTGCTG	0.657		NA							Smith-Lemli-Opitz_syndrome				10	29					0	0	0	0
SLC35F2	54733	broad.mit.edu	37	11	107682478	107682478	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:107682478T>A	uc001pjq.2	-	3	750	c.329A>T	c.(328-330)AAG>ATG	p.K110M	SLC35F2_uc010rvu.1_Translation_Start_Site|SLC35F2_uc001pjs.2_Missense_Mutation_p.K110M	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	110	Helical; (Potential).				transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAGGATGTACTTCCACCATTT	0.418		NA											33	122					0	0	0	0
PTS	5805	broad.mit.edu	37	11	112101363	112101363	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:112101363G>C	uc001pnj.3	+	4	280	c.201G>C	c.(199-201)ACG>ACC	p.T67T	PTS_uc009yyo.2_RNA	NM_000317	NP_000308	Q03393	PTPS_HUMAN	6-pyruvoyltetrahydropterin synthase	67			T -> M (in HPABH4A).		cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding				0		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)		ACCCTGCTACGGGAATGGTTA	0.383		NA											3	77					0	0	0	0
APLP2	334	broad.mit.edu	37	11	129996669	129996669	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:129996669C>A	uc010sby.1	+	8	1322	c.1165C>A	c.(1165-1167)CGC>AGC	p.R389S	APLP2_uc001qfp.2_Missense_Mutation_p.R389S|APLP2_uc001qfq.2_Missense_Mutation_p.R333S|APLP2_uc010sbz.1_Missense_Mutation_p.R177S|APLP2_uc001qfr.2_Missense_Mutation_p.R155S|APLP2_uc001qfs.2_Missense_Mutation_p.R160S|APLP2_uc001qfv.2_Missense_Mutation_p.R280S	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	389	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGAGCATGCTCGCTTCCAGAA	0.468		NA											7	104					0.000157383	0.0030423	1	0
SNX19	399979	broad.mit.edu	37	11	130785040	130785040	+	Silent	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:130785040C>G	uc001qgk.3	-	1	1343	c.795G>C	c.(793-795)GTG>GTC	p.V265V	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.V265V|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	265	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		AAAAGATACCCACGAGTACAA	0.552		NA											4	65					0	0	0	0
GALNT8	26290	broad.mit.edu	37	12	4835909	4835909	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:4835909G>C	uc001qne.1	+	2	515	c.423G>C	c.(421-423)CAG>CAC	p.Q141H		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	141	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AGGCGGCCCAGGACCTCTTCC	0.547		NA											4	21					0	0	0	0
LTBR	4055	broad.mit.edu	37	12	6495602	6495602	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:6495602A>G	uc001qny.1	+	6	827	c.659A>G	c.(658-660)GAG>GGG	p.E220G	LTBR_uc010sfc.1_Missense_Mutation_p.E201G|LTBR_uc001qnz.1_Missense_Mutation_p.E215G	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	220	Extracellular (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						CTGCCCCCAGAGATGTCAGGT	0.547		NA											6	7					0	0	0	0
PRH1	5554	broad.mit.edu	37	12	11035684	11035684	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:11035684C>A	uc001qzc.2	-	6	664	c.76G>T	c.(76-78)GAA>TAA	p.E26*	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	26	Inhibits hydroxyapatite formation, binds to hydroxyapatite and calcium.					extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		GGAACATCTTCCTGGCTGACA	0.398		NA											15	54					2.94e-08	6.55e-07	1	0
PRB3	5544	broad.mit.edu	37	12	11420146	11420146	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:11420146G>C	uc001qzs.2	-	4	948	c.910C>G	c.(910-912)CAG>GAG	p.Q304E	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	304	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGCTGTCCCTGGGGAGGTCTG	0.517		NA											14	30					0	0	0	0
LDHB	3945	broad.mit.edu	37	12	21788507	21788507	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:21788507C>A	uc001rfc.2	-	7	992	c.974G>T	c.(973-975)TGG>TTG	p.W325L	LDHB_uc001rfd.2_Missense_Mutation_p.W325L|LDHB_uc001rfe.2_Missense_Mutation_p.W325L	NM_002300	NP_002291	P07195	LDHB_HUMAN	L-lactate dehydrogenase B	325			W -> R (in LDHB deficiency).		glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)	CTGGATGTCCCACAGGGTATC	0.438		NA											8	144					0.000442599	0.00827283	1	0
C12orf35	55196	broad.mit.edu	37	12	32135423	32135423	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:32135423A>T	uc001rks.2	+	4	1948	c.1534A>T	c.(1534-1536)AAG>TAG	p.K512*		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	512										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CTATTCTGAAAAGCGGCCAAT	0.388		NA											10	55					0	0	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966845	41966845	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:41966845C>A	uc010skn.1	+	10	1735	c.1667C>A	c.(1666-1668)TCC>TAC	p.S556Y	PDZRN4_uc001rmq.3_Missense_Mutation_p.S497Y|PDZRN4_uc009zjz.2_Missense_Mutation_p.S495Y|PDZRN4_uc001rmr.2_Missense_Mutation_p.S382Y	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	755							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GTAGACCGTTCCCCTGACAGT	0.498		NA											8	35					1.13e-05	0.000231687	1	0
COPZ1	22818	broad.mit.edu	37	12	54744287	54744287	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:54744287A>G	uc001sfs.1	+	9	551	c.514A>G	c.(514-516)AAG>GAG	p.K172E	COPZ1_uc001sft.2_Missense_Mutation_p.K121E|COPZ1_uc009znm.1_Missense_Mutation_p.K180E|COPZ1_uc010sot.1_Missense_Mutation_p.K149E	NM_016057	NP_057141	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	172					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0						AGAACAGATCAAGTGGTCACT	0.493		NA											8	112					0	0	0	0
MON2	23041	broad.mit.edu	37	12	62938684	62938684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:62938684C>T	uc001sre.2	+	21	2864	c.2473C>T	c.(2473-2475)CAG>TAG	p.Q825*	MON2_uc009zqj.2_Nonsense_Mutation_p.Q825*|MON2_uc010ssl.1_Nonsense_Mutation_p.Q753*|MON2_uc010ssm.1_Nonsense_Mutation_p.Q802*|MON2_uc010ssn.1_Nonsense_Mutation_p.Q825*|MON2_uc001srf.2_Nonsense_Mutation_p.Q588*	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	826					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCAGGTCTGCCAGCATCCAAA	0.333		NA											12	40					0	0	0	0
GRIP1	23426	broad.mit.edu	37	12	66770984	66770984	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:66770984G>A	uc001stk.2	-	20	2788	c.2547C>T	c.(2545-2547)TGC>TGT	p.C849C	GRIP1_uc010sta.1_Silent_p.C793C|GRIP1_uc001stj.2_Silent_p.C631C|GRIP1_uc001stl.1_Silent_p.C741C|GRIP1_uc001stm.2_Silent_p.C849C	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	901					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTGACTGTCCGCAGGTTTCCA	0.443		NA											37	166					0	0	0	0
C12orf26	84190	broad.mit.edu	37	12	82870447	82870447	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:82870447T>A	uc001szq.2	+	10	1618	c.1597T>A	c.(1597-1599)TAC>AAC	p.Y533N		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	533											0						TATAATGAACTACTACGAGAA	0.284		NA											18	95					0	0	0	0
CRY1	1407	broad.mit.edu	37	12	107395137	107395137	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:107395137G>T	uc001tmi.3	-	5	1464	c.605C>A	c.(604-606)ACA>AAA	p.T202K		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	202					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						TAAGCCATCTGTATCAAAACC	0.343		NA											5	73					0.000274275	0.00521276	1	0
SFRS8	6433	broad.mit.edu	37	12	132238982	132238982	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:132238982C>T	uc001uja.1	+	9	1532	c.1392C>T	c.(1390-1392)GCC>GCT	p.A464A	SFRS8_uc010tbn.1_Silent_p.A464A|SFRS8_uc001ujb.1_Silent_p.A257A|SFRS8_uc001uiz.1_Silent_p.A338A	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	464	SURP motif 2.				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		ACAAGCTGGCCGAGTATGTCG	0.557		NA											4	33					0	0	0	0
BRCA2	675	broad.mit.edu	37	13	32971100	32971100	+	Silent	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr13:32971100C>A	uc001uub.1	+	26	9794	c.9567C>A	c.(9565-9567)CCC>CCA	p.P3189P		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3189					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAAATGATCCCAAGTGGTCCA	0.378		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			10	192					0.00010058	0.00197235	1	0
POSTN	10631	broad.mit.edu	37	13	38138655	38138655	+	Splice_Site	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr13:38138655C>T	uc001uwo.3	-	22	2591	c.2473_splice	c.e22+1	p.G825_splice	POSTN_uc010tet.1_Splice_Site_p.G326_splice|POSTN_uc001uwp.3_Splice_Site_p.G768_splice|POSTN_uc001uwr.2_Splice_Site_p.G770_splice|POSTN_uc001uwq.2_Splice_Site_p.G740_splice	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AATACACTTACCTTGAACTTT	0.323		NA											28	96					0	0	0	0
SLC39A2	29986	broad.mit.edu	37	14	21469108	21469109	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:21469108_21469109GG>TT	uc001vyr.2	+	4	487_488	c.300_301GG>TT	c.(298-303)ATGGAG>ATTTAG	p.100_101ME>I*	SLC39A2_uc001vys.2_Nonsense_Mutation_p.1_2ME>I*	NM_014579	NP_055394	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter),	100_101	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			ovary(2)|central_nervous_system(1)	3	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		GTTTCTAGATGGAGTATCCCTA	0.47		NA											14	366					0	0	0	0
CHD8	57680	broad.mit.edu	37	14	21874023	21874023	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:21874023C>A	uc001was.1	-	15	2165	c.2071G>T	c.(2071-2073)GAA>TAA	p.E691*	CHD8_uc001war.1_Nonsense_Mutation_p.E587*|CHD8_uc001wav.1_Nonsense_Mutation_p.E133*	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	970	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACCTTGTGTTCCTAGAAATGG	0.333		NA											18	32					9.17e-09	2.06e-07	1	0
DHRS4L1	728635	broad.mit.edu	37	14	24511906	24511906	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:24511906C>T	uc010alc.2	+	3	316	c.316C>T	c.(316-318)CTT>TTT	p.L106F	DHRS4L1_uc010tnu.1_Intron	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4	106							binding|oxidoreductase activity				0						GGCTATGAAGCTTCATGGAGT	0.408		NA											18	98					0	0	0	0
DDHD1	80821	broad.mit.edu	37	14	53527915	53527915	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:53527915T>C	uc001xai.2	-	8	2001	c.1771A>G	c.(1771-1773)AAG>GAG	p.K591E	DDHD1_uc001xaj.2_Missense_Mutation_p.K598E|DDHD1_uc001xah.2_Missense_Mutation_p.K591E|DDHD1_uc001xag.2_Missense_Mutation_p.K173E|DDHD1_uc001xak.1_5'UTR	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	591					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					TCTATTTCCTTCAGCCTAAGA	0.348		NA											15	79					0	0	0	0
SLC35F4	341880	broad.mit.edu	37	14	58060704	58060704	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:58060704C>A	uc001xdb.1	-	2	350	c.350G>T	c.(349-351)GGA>GTA	p.G117V	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TCCTGAGGATCCTTGGTTTTG	0.468		NA											7	35					0.000157383	0.0030423	1	0
SYNE2	23224	broad.mit.edu	37	14	64443439	64443439	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:64443439A>T	uc001xgm.2	+	12	1517	c.1287A>T	c.(1285-1287)TTA>TTT	p.L429F	SYNE2_uc001xgl.2_Missense_Mutation_p.L429F	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	429	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAATGACTTTATTCAAGGTTG	0.383		NA											14	142					0	0	0	0
GSC	145258	broad.mit.edu	37	14	95234883	95234883	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:95234883G>A	uc001ydu.2	-	3	866	c.719C>T	c.(718-720)GCG>GTG	p.A240V		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	240					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		CTCCGGTGACGCCTTCGACGA	0.572		NA											13	105					0	0	0	0
ATG2B	55102	broad.mit.edu	37	14	96772063	96772063	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:96772063G>C	uc001yfi.2	-	31	4961	c.4596C>G	c.(4594-4596)ACC>ACG	p.T1532T		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1532										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGCTCGTATCGGTCTTATTAA	0.403		NA											3	48					0	0	0	0
AK7	122481	broad.mit.edu	37	14	96864496	96864496	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:96864496C>A	uc001yfn.2	+	2	234	c.190C>A	c.(190-192)CTG>ATG	p.L64M	AK7_uc001yfm.1_Missense_Mutation_p.L64M	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	64	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GTCAGCTATGCTGGAAGCTTC	0.488		NA											13	72					1.36e-06	2.91e-05	1	0
RAGE	5891	broad.mit.edu	37	14	102717262	102717262	+	Silent	SNP	C	C	G	rs142858806		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:102717262C>G	uc001ylm.2	-	7	703	c.477G>C	c.(475-477)ACG>ACC	p.T159T	RAGE_uc010txv.1_Silent_p.T129T|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	159	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGATGTATTCCGTGTACGGCT	0.557		NA											3	49					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105419866	105419866	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:105419866G>T	uc010axc.1	-	7	2042	c.1922C>A	c.(1921-1923)TCA>TAA	p.S641*	AHNAK2_uc001ypx.2_Nonsense_Mutation_p.S541*	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	641						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTTTGTCATTGAGTCACTGTC	0.423		NA											12	297					0.000422831	0.0079914	1	0
MTA1	9112	broad.mit.edu	37	14	105930441	105930441	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:105930441G>T	uc001yqx.2	+	13	1336	c.1149G>T	c.(1147-1149)CCG>CCT	p.P383P	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Silent_p.P144P	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	383					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGGGGGCGCCGGGCCAGAGCC	0.652		NA											15	40					5.01e-05	0.00100308	1	0
TGM7	116179	broad.mit.edu	37	15	43585695	43585695	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:43585695G>T	uc001zrf.1	-	2	150	c.145C>A	c.(145-147)CGA>AGA	p.R49R		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	49					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TGGAAGGGTCGGCTGAAGCTC	0.617		NA											27	56					1.38e-23	3.22e-22	1	0
DIS3L	115752	broad.mit.edu	37	15	66587415	66587415	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:66587415G>T	uc010ujm.1	+	2	244	c.229G>T	c.(229-231)GAG>TAG	p.E77*	DIS3L_uc010ujl.1_5'UTR|DIS3L_uc002app.2_5'UTR|DIS3L_uc002apq.2_Nonsense_Mutation_p.E77*|DIS3L_uc010bho.2_5'UTR	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	77					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						TGAGTTTCCTGAGTTGAAGGG	0.393		NA											8	119					0.000442599	0.00827283	1	0
EFTUD1	79631	broad.mit.edu	37	15	82512439	82512439	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:82512439G>T	uc002bgt.1	-	13	1593	c.1424C>A	c.(1423-1425)CCA>CAA	p.P475Q	EFTUD1_uc002bgu.1_Missense_Mutation_p.P424Q	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	475					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						CTCTCCTTTTGGACATGTTTC	0.493		NA											11	121					6.32e-08	1.4e-06	1	0
ANPEP	290	broad.mit.edu	37	15	90347556	90347556	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:90347556G>A	uc002bop.3	-	6	1399	c.1107C>T	c.(1105-1107)TTC>TTT	p.F369F		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	369	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ACAGGGGGTCGAACAGCAGGG	0.632		NA											7	28					0	0	0	0
BLM	641	broad.mit.edu	37	15	91346911	91346912	+	Nonsense_Mutation	DNP	CG	CG	AT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:91346911_91346912CG>AT	uc002bpr.2	+	18	3616_3617	c.3519_3520CG>AT	c.(3517-3522)CTCGGA>CTATGA	p.G1174*	BLM_uc010uqh.1_Nonsense_Mutation_p.G1174*|BLM_uc010uqi.1_Nonsense_Mutation_p.G799*|BLM_uc010bnx.2_Intron|BLM_uc002bpt.2_Nonsense_Mutation_p.G149*	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1174					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			ATGTGATGCTCGGAAATAAAGC	0.317		NA	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				8	213					0	0	0	0
RRN3	54700	broad.mit.edu	37	16	15157137	15157137	+	Silent	SNP	T	T	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:15157137T>G	uc002dde.2	-	17	1778	c.1710A>C	c.(1708-1710)TCA>TCC	p.S570S	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Silent_p.S438S|RRN3_uc010uzq.1_Silent_p.S540S	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	570	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						TGAATTTCTTTGACCTGTCAA	0.373		NA											18	96					0	0	0	0
CDR2	1039	broad.mit.edu	37	16	22360714	22360714	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:22360714C>T	uc002dkn.2	-	4	700	c.392G>A	c.(391-393)AGC>AAC	p.S131N		NM_001802	NP_001793	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2	131	Potential.					nucleus	protein binding			skin(1)	1				GBM - Glioblastoma multiforme(48;0.0188)		CTCCACTTGGCTCTGGAGGTG	0.527		NA											27	60					0	0	0	0
SALL1	6299	broad.mit.edu	37	16	51173271	51173271	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:51173271G>A	uc010vgs.1	-	2	2893	c.2862C>T	c.(2860-2862)AGC>AGT	p.S954S	SALL1_uc010vgr.1_Silent_p.S857S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	954					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCAAACTCGCTTGGGACCG	0.517		NA											13	22					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65005485	65005485	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:65005485G>A	uc002eoi.2	-	11	2073	c.1639C>T	c.(1639-1641)CGA>TGA	p.R547*	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Nonsense_Mutation_p.R547*|CDH11_uc010vin.1_Nonsense_Mutation_p.R421*	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	547	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TACAAACCTCGGTTGTCTCTG	0.398		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	50					0	0	0	0
DDX19A	55308	broad.mit.edu	37	16	70333201	70333201	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:70333201A>G	uc002eys.2	+	1	130	c.1A>G	c.(1-3)ATG>GTG	p.M1V	DDX19B_uc010vly.1_Missense_Mutation_p.M1V|DDX19B_uc010vlv.1_Intron|DDX19B_uc010vlw.1_Intron|DDX19B_uc002eyo.2_Missense_Mutation_p.M1V|DDX19B_uc002eyp.2_Missense_Mutation_p.M1V|DDX19B_uc002eyq.2_5'UTR|DDX19B_uc002eyr.2_5'UTR|DDX19B_uc010vlx.1_5'UTR	NM_007242	NP_009173	Q9NUU7	DD19A_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	1					mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				GCCTGGGACCATGGCCACTGA	0.667		NA											3	4					0	0	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76501310	76501310	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:76501310T>A	uc002feu.1	+	12	1930	c.1545T>A	c.(1543-1545)TGT>TGA	p.C515*	CNTNAP4_uc002fev.1_Nonsense_Mutation_p.C379*|CNTNAP4_uc010chb.1_Nonsense_Mutation_p.C442*|CNTNAP4_uc002fex.1_Nonsense_Mutation_p.C518*|CNTNAP4_uc002few.2_Nonsense_Mutation_p.C490*	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	515	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TTCAGGGATGTATGAGGCTCA	0.433		NA											11	25					0	0	0	0
ASGR2	433	broad.mit.edu	37	17	7017444	7017444	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:7017444A>G	uc002gep.3	-	2	381	c.116T>C	c.(115-117)TTT>TCT	p.F39S	ASGR2_uc002gem.1_5'UTR|ASGR2_uc002gen.1_Intron|ASGR2_uc002geo.1_Missense_Mutation_p.F39S|ASGR2_uc002ger.3_Missense_Mutation_p.F39S|ASGR2_uc002geq.3_Intron|ASGR2_uc010clw.2_Intron|ASGR2_uc010vtl.1_Intron	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	39	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	GCCTTTCAAAAATGGATTTCC	0.537		NA											10	46					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Silent	SNP	C	C	A	rs55863639		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:7579312C>A	uc002gim.2	-	4	569	c.375G>T	c.(373-375)ACG>ACT	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	25					2.94e-08	6.55e-07	1	0
RHBDL3	162494	broad.mit.edu	37	17	30621436	30621436	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:30621436C>A	uc002hhe.1	+	5	657	c.643C>A	c.(643-645)CTG>ATG	p.L215M	RHBDL3_uc010csw.1_Missense_Mutation_p.L207M|RHBDL3_uc010csx.1_Missense_Mutation_p.L215M|RHBDL3_uc010csy.1_Missense_Mutation_p.L117M|RHBDL3_uc002hhf.1_Missense_Mutation_p.L117M	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	215					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				TTGGCGCTACCTGACATACAT	0.463		NA											9	36					1.13e-05	0.000231687	1	0
C17orf66	256957	broad.mit.edu	37	17	34185928	34185928	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:34185928C>T	uc002hke.1	-	9	1052	c.903G>A	c.(901-903)CAG>CAA	p.Q301Q	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Silent_p.Q261Q|C17orf66_uc010wcm.1_Silent_p.Q267Q	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	301							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GGCACAGGCACTGCAACAAGA	0.567		NA											9	55					0	0	0	0
HSPB9	94086	broad.mit.edu	37	17	40275302	40275302	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:40275302C>T	uc002hyy.2	+	1	547	c.434C>T	c.(433-435)CCG>CTG	p.P145L	KAT2A_uc002hyx.2_5'Flank	NM_033194	NP_149971	Q9BQS6	HSPB9_HUMAN	heat shock protein, alpha-crystallin-related,	145					response to stress	cytoplasm|nucleus	protein binding				0		all_cancers(22;0.00064)|Breast(137;0.00104)|all_epithelial(22;0.00866)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GGACCGTCCCCGAGACTCGGG	0.637		NA											9	26					0	0	0	0
TUBG1	7283	broad.mit.edu	37	17	40766632	40766632	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:40766632G>A	uc002ian.2	+	10	1513	c.1115G>A	c.(1114-1116)CGG>CAG	p.R372Q		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	372					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TCGGCCCACCGGGTCAGCGGG	0.592		NA											15	45					0	0	0	0
CCDC47	57003	broad.mit.edu	37	17	61843274	61843274	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:61843274G>T	uc002jbs.3	-	2	598	c.262C>A	c.(262-264)CAG>AAG	p.Q88K	CCDC47_uc010ddx.2_Missense_Mutation_p.Q88K|CCDC47_uc002jbt.2_Missense_Mutation_p.Q88K	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	88						integral to membrane	protein binding				0						AGCCTCACCTGGGTATCTGCA	0.393		NA											12	215					0.00010058	0.00197235	1	0
RNF213	57674	broad.mit.edu	37	17	78319551	78319551	+	Silent	SNP	C	C	T	rs143772929		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:78319551C>T	uc002jyh.1	+	4	1858	c.1635C>T	c.(1633-1635)TTC>TTT	p.F545F		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATGTGGCCTTCGCCAATAAGG	0.463		NA											12	50					0	0	0	0
PTPRM	5797	broad.mit.edu	37	18	8143677	8143677	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr18:8143677G>A	uc002knn.3	+	14	2703	c.2200G>A	c.(2200-2202)GAG>AAG	p.E734K	PTPRM_uc010dkv.2_Missense_Mutation_p.E734K|PTPRM_uc010wzl.1_Missense_Mutation_p.E521K	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	734	Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CCCAGAACCCGAGAAACAGAC	0.423		NA											12	60					0	0	0	0
MYO5B	4645	broad.mit.edu	37	18	47421488	47421488	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr18:47421488G>C	uc002leb.2	-	22	3156	c.2868C>G	c.(2866-2868)ACC>ACG	p.T956T	MYO5B_uc002lea.2_Silent_p.T97T	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	956	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CTACCTCCATGGTGTATGTTG	0.552		NA											3	37					0	0	0	0
SHC2	25759	broad.mit.edu	37	19	436383	436383	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:436383T>C	uc002loq.3	-	6	823	c.823A>G	c.(823-825)AGA>GGA	p.R275G	SHC2_uc002lop.3_Missense_Mutation_p.R16G	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	275	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCACCTCTCTGGTTGATG	0.716		NA											9	16					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9069845	9069845	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:9069845A>G	uc002mkp.2	-	3	17805	c.17601T>C	c.(17599-17601)CCT>CCC	p.P5867P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5869	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGTCCCTATAGGACCTGTTT	0.493		NA											3	79					0	0	0	0
KEAP1	9817	broad.mit.edu	37	19	10610177	10610177	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:10610177T>A	uc002moq.1	-	2	689	c.533A>T	c.(532-534)CAG>CTG	p.Q178L	KEAP1_uc002mor.1_Missense_Mutation_p.Q178L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGGGTCCAGCTGCTGCACCAG	0.567		NA											6	9					0	0	0	0
PLVAP	83483	broad.mit.edu	37	19	17476149	17476149	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:17476149G>T	uc002ngk.1	-	3	1175	c.1125C>A	c.(1123-1125)CTC>CTA	p.L375L		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	375	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						GCTCCATCCTGAGCTGCTCCG	0.617		NA											15	40					8.01e-06	0.000167655	1	0
SF4	57794	broad.mit.edu	37	19	19416690	19416690	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:19416690T>C	uc002nmh.2	-	4	508	c.506A>G	c.(505-507)GAG>GGG	p.E169G	SF4_uc002nmg.2_5'Flank|SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	169					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						ATAGTCCTCCTCCTCGTCCTC	0.647		NA											6	31					0	0	0	0
PSG8	440533	broad.mit.edu	37	19	43262160	43262160	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:43262160G>A	uc002ouo.2	-	3	801	c.703C>T	c.(703-705)CTC>TTC	p.L235F	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.L74F|PSG8_uc002ouh.2_Missense_Mutation_p.L235F|PSG8_uc010ein.2_Missense_Mutation_p.L113F|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Missense_Mutation_p.L74F|PSG8_uc002oul.3_Missense_Mutation_p.L235F|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	235						extracellular region					0		Prostate(69;0.00899)				TCACGGAGGAGATTCAGGGTG	0.527		NA											24	117					0	0	0	0
ZNF229	7772	broad.mit.edu	37	19	44934288	44934288	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:44934288C>G	uc002oze.1	-	6	1102	c.668G>C	c.(667-669)TGC>TCC	p.C223S	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Missense_Mutation_p.C217S	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				AGATATCCAGCAAAAGCTGTC	0.378		NA											5	94					0	0	0	0
ZNF577	84765	broad.mit.edu	37	19	52383578	52383578	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:52383578C>G	uc010yde.1	-	4	449	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	ZNF577_uc010ydd.1_RNA|ZNF577_uc002pxx.3_Missense_Mutation_p.E20Q|ZNF577_uc002pxv.2_Missense_Mutation_p.E13Q|ZNF577_uc002pxw.2_Missense_Mutation_p.E13Q	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		aaatttacctcccctgaagaa	0.03		NA											22	110					0	0	0	0
ZNF649	65251	broad.mit.edu	37	19	52394790	52394790	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:52394790T>C	uc002pxy.2	-	5	867	c.599A>G	c.(598-600)CAT>CGT	p.H200R	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	200	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTCCTGTATGAATTCTCTT	0.463		NA											11	45					0	0	0	0
CACNG8	59283	broad.mit.edu	37	19	54466610	54466610	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54466610G>A	uc002qcs.1	+	1	317	c.211G>A	c.(211-213)GGC>AGC	p.G71S		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	72					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CGGGGGCGGCGGCGCCTCGGA	0.726		NA											3	7					0	0	0	0
LILRB3	11025	broad.mit.edu	37	19	54746049	54746049	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54746049C>A	uc010erh.1	-	3	332	c.208G>T	c.(208-210)GAC>TAC	p.D70Y	LILRA6_uc002qew.1_Missense_Mutation_p.D70Y|LILRB3_uc002qeh.1_Missense_Mutation_p.D70Y|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.D70Y|LILRA6_uc002qek.1_Missense_Mutation_p.D70Y|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.D70Y|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.D70Y|LILRB3_uc002qep.1_Missense_Mutation_p.D70Y|LILRB3_uc002qeq.1_Missense_Mutation_p.D70Y|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.D70Y|LILRA6_uc010yep.1_Missense_Mutation_p.D70Y|LILRA6_uc010yeq.1_Missense_Mutation_p.D70Y|LILRA6_uc002qet.3_RNA|LILRA6_uc002qeu.1_Missense_Mutation_p.D70Y|LILRA6_uc002qev.1_5'Flank	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	70	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTATTTCTGTCCAAGGGCTCT	0.567		NA											18	147					2.98e-07	6.47e-06	1	0
PTPRH	5794	broad.mit.edu	37	19	55718094	55718094	+	Silent	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:55718094T>A	uc002qjq.2	-	3	388	c.315A>T	c.(313-315)GGA>GGT	p.G105G	PTPRH_uc010esv.2_Silent_p.G105G|PTPRH_uc002qjs.2_Silent_p.G112G	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	105	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGCTATTTACTCCGTCTTTCT	0.498		NA											14	80					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57328305	57328305	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:57328305C>T	uc002qnu.2	-	7	1856	c.1505G>A	c.(1504-1506)GGG>GAG	p.G502E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G473E|PEG3_uc002qnv.2_Missense_Mutation_p.G502E|PEG3_uc002qnw.2_Missense_Mutation_p.G378E|PEG3_uc002qnx.2_Missense_Mutation_p.G376E|PEG3_uc010etr.2_Missense_Mutation_p.G502E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	502					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAAACGTTTCCCTCCAACCTG	0.453		NA											15	83					0	0	0	0
TTC15	51112	broad.mit.edu	37	2	3405563	3405563	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:3405563G>C	uc002qxm.1	+	3	1269	c.1063G>C	c.(1063-1065)GAC>CAC	p.D355H	TTC15_uc002qxn.1_Missense_Mutation_p.D355H|TTC15_uc010ewm.1_Missense_Mutation_p.D355H	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	355							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		TGCAGTTAAAGACTTGATGCT	0.378		NA											17	135					0	0	0	0
FAM179A	165186	broad.mit.edu	37	2	29240047	29240047	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:29240047C>G	uc010ezl.2	+	9	1423	c.1072C>G	c.(1072-1074)CGG>GGG	p.R358G	FAM179A_uc010ymm.1_Missense_Mutation_p.R358G|FAM179A_uc002rmr.3_Intron	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	358							binding			ovary(3)|skin(1)	4						CAAGTCTGCCCGGGAGAAGAT	0.493		NA											4	93					0	0	0	0
ALMS1	7840	broad.mit.edu	37	2	73826530	73826530	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:73826530A>G	uc002sje.1	+	19	11664	c.11553A>G	c.(11551-11553)GTA>GTG	p.V3851V	ALMS1_uc002sjf.1_Silent_p.V3807V|ALMS1_uc002sjh.1_Silent_p.V3237V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3849					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTTTCTAGGTAGCAAACCATG	0.368		NA											36	180					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116510785	116510785	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:116510785A>T	uc002tla.1	+	11	1443	c.986A>T	c.(985-987)AAT>ATT	p.N329I	DPP10_uc002tlb.1_Missense_Mutation_p.N279I|DPP10_uc002tlc.1_Missense_Mutation_p.N325I|DPP10_uc002tle.2_Missense_Mutation_p.N333I|DPP10_uc002tlf.1_Missense_Mutation_p.N322I	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	329	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TGGGTAAGCAATACCAAGACT	0.363		NA											10	41					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168107879	168107879	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:168107879T>A	uc002udx.2	+	8	9995	c.9977T>A	c.(9976-9978)GTG>GAG	p.V3326E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V3151E|XIRP2_uc010fpq.2_Missense_Mutation_p.V3104E|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3151					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAAAATTTCGTGAATGACCCT	0.443		NA											7	78					0	0	0	0
FASTKD2	22868	broad.mit.edu	37	2	207651558	207651558	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:207651558A>T	uc002vbu.2	+	8	1939	c.1529A>T	c.(1528-1530)TAC>TTC	p.Y510F	FASTKD2_uc002vbv.2_Missense_Mutation_p.Y510F|FASTKD2_uc002vbx.2_Missense_Mutation_p.Y510F|FASTKD2_uc002vbw.1_Missense_Mutation_p.Y510F	NM_001136193	NP_001129665	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	510					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|skin(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		TTGATGAATTACTTTCCCCTG	0.403		NA											35	80					0	0	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209200049	209200049	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:209200049C>T	uc002vcz.2	+	25	4320	c.4162C>T	c.(4162-4164)CTT>TTT	p.L1388F	PIKFYVE_uc002vcy.1_Missense_Mutation_p.L1332F	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1388					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						CATTCGGCTTCTTGAAGTATG	0.363		NA											71	134					0	0	0	0
CPS1	1373	broad.mit.edu	37	2	211539654	211539654	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:211539654T>A	uc002vee.3	+	35	4262	c.4130T>A	c.(4129-4131)GTG>GAG	p.V1377E	CPS1_uc010fur.2_Missense_Mutation_p.V1383E|CPS1_uc010fus.2_Missense_Mutation_p.V926E	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1377					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCCTTGGTGTGGCTGAACAA	0.343		NA											18	121					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	227920692	227920692	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:227920692A>G	uc010zlt.1	-	30	3339	c.2685T>C	c.(2683-2685)GAT>GAC	p.D895D		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	895	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTAGCCCATCATCTCCAAAGG	0.582		NA											5	18					0	0	0	0
DGKD	8527	broad.mit.edu	37	2	234296984	234296984	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:234296984C>T	uc002vui.1	+	2	250	c.238C>T	c.(238-240)CGA>TGA	p.R80*	DGKD_uc002vuj.1_Nonsense_Mutation_p.R36*	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	80	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity	p.R80Q(1)		central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCTTCGAGGGCGAACGCTTTA	0.507		NA											25	59					0	0	0	0
HDAC4	9759	broad.mit.edu	37	2	240061464	240061464	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:240061464G>A	uc002vyk.3	-	9	1686	c.894C>T	c.(892-894)TCC>TCT	p.S298S	HDAC4_uc010fyz.1_Silent_p.S293S|HDAC4_uc010zoa.1_Silent_p.S293S|HDAC4_uc010fza.2_Silent_p.S298S|HDAC4_uc010fyy.2_Silent_p.S250S|HDAC4_uc010znz.1_Silent_p.S181S|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	298	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AGCTGGGTCCGGAGCCTGGGG	0.677		NA											16	28					0	0	0	0
XRN2	22803	broad.mit.edu	37	20	21336733	21336733	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:21336733T>C	uc002wsf.1	+	22	2131	c.2036T>C	c.(2035-2037)CTT>CCT	p.L679P	XRN2_uc002wsg.1_Missense_Mutation_p.L603P|XRN2_uc010zsk.1_Missense_Mutation_p.L625P	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	679					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						AGAAACAGCCTTGGAGGTGAT	0.403		NA											7	55					0	0	0	0
TH1L	51497	broad.mit.edu	37	20	57564012	57564012	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:57564012G>C	uc002yag.2	+	5	494	c.467G>C	c.(466-468)CGG>CCG	p.R156P	TH1L_uc010zzu.1_Missense_Mutation_p.R156P|TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.R156P	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	156					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			ACCACGTGGCGGGACCTTTTT	0.478		NA											3	46					0	0	0	0
TTC3	7267	broad.mit.edu	37	21	38516833	38516833	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr21:38516833A>C	uc002yvz.2	+	21	1886	c.1781A>C	c.(1780-1782)GAA>GCA	p.E594A	TTC3_uc011aee.1_Missense_Mutation_p.E284A|TTC3_uc002ywa.2_Missense_Mutation_p.E594A|TTC3_uc002ywb.2_Missense_Mutation_p.E594A|TTC3_uc010gnf.2_Missense_Mutation_p.E359A|TTC3_uc002ywc.2_Missense_Mutation_p.E284A|TTC3_uc011aed.1_Missense_Mutation_p.E284A|TTC3_uc010gne.1_Missense_Mutation_p.E594A	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	594	TPR 4.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AGATTTCTAGAAGCTCTCAAT	0.373		NA											25	83					0	0	0	0
IGSF5	150084	broad.mit.edu	37	21	41151062	41151063	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr21:41151062_41151063CG>AT	uc002yyo.2	+	5	867_868	c.764_765CG>AT	c.(763-765)CCG>CAT	p.P255H		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	255	Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				TCAAGTTTACCGAGTTTAGGTT	0.381		NA											5	68					0	0	0	0
NEFH	4744	broad.mit.edu	37	22	29885318	29885318	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:29885318G>T	uc003afo.2	+	4	1760	c.1689G>T	c.(1687-1689)GAG>GAT	p.E563D	NEFH_uc003afp.2_Intron	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	563	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|5.|Tail.				cell death|nervous system development	neurofilament					0						CACCGCCTGAGGCCAAGTCCC	0.572		NA											6	39					2.01e-06	4.26e-05	1	0
DEPDC5	9681	broad.mit.edu	37	22	32200153	32200153	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:32200153G>T	uc003als.2	+	16	1229	c.1087G>T	c.(1087-1089)GGT>TGT	p.G363C	DEPDC5_uc011als.1_Missense_Mutation_p.G363C|DEPDC5_uc011alu.1_Missense_Mutation_p.G363C|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.G363C|DEPDC5_uc003alr.1_Missense_Mutation_p.G363C|DEPDC5_uc011alt.1_Missense_Mutation_p.G335C	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	363					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TTTAGGAATTGGTGTGGATTT	0.393		NA											7	69					8.13e-05	0.00160786	1	0
IQSEC1	9922	broad.mit.edu	37	3	12977740	12977740	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:12977740G>A	uc003bxt.2	-	3	827	c.818C>T	c.(817-819)GCG>GTG	p.A273V	IQSEC1_uc003bxu.3_Missense_Mutation_p.A151V|IQSEC1_uc011auw.1_Missense_Mutation_p.A259V	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	273					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GGCCCGCGCCGCATCCAGGGC	0.642		NA											8	24					0	0	0	0
KCNH8	131096	broad.mit.edu	37	3	19498349	19498349	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:19498349C>A	uc003cbk.1	+	11	2110	c.1915C>A	c.(1915-1917)CTC>ATC	p.L639I	KCNH8_uc010hex.1_Missense_Mutation_p.L100I	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	639	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CTACTGTGATCTCCAGTGTAT	0.403		NA											21	50					5.26e-13	1.2e-11	1	0
XIRP1	165904	broad.mit.edu	37	3	39227609	39227609	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:39227609C>A	uc003cjk.1	-	2	3549	c.3328G>T	c.(3328-3330)GAT>TAT	p.D1110Y	XIRP1_uc003cji.2_Missense_Mutation_p.D1110Y|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1110							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		ATCCGGGGATCACTTCCACCC	0.607		NA											12	28					6.4e-05	0.00127371	1	0
ZNF660	285349	broad.mit.edu	37	3	44636533	44636533	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:44636533T>A	uc003cnl.1	+	3	1181	c.848T>A	c.(847-849)TTC>TAC	p.F283Y		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	283	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GGGAAAACCTTCAGGCAGACT	0.413		NA											11	25					0	0	0	0
CELSR3	1951	broad.mit.edu	37	3	48694142	48694142	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:48694142G>C	uc003cul.2	-	2	4669	c.4388C>G	c.(4387-4389)CCG>CGG	p.P1463R	CELSR3_uc003cuf.1_Missense_Mutation_p.P1533R	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1463	Extracellular (Potential).|EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGAAGCGCGGGCGGCAGAC	0.687		NA											2	1					0	0	0	0
IP6K1	9807	broad.mit.edu	37	3	49775724	49775724	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:49775724G>C	uc003cxm.1	-	3	670	c.355C>G	c.(355-357)CGC>GGC	p.R119G	IP6K1_uc003cxn.1_5'UTR|IP6K1_uc011bcv.1_5'UTR|IP6K1_uc003cxo.2_Missense_Mutation_p.R119G	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	119					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						AGGCTCCGGCGGGAGTGTTTG	0.542		NA											4	39					0	0	0	0
CCDC14	64770	broad.mit.edu	37	3	123665745	123665745	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:123665745T>A	uc011bjx.1	-	8	1341	c.1250A>T	c.(1249-1251)GAT>GTT	p.D417V	CCDC14_uc003egv.3_Intron|CCDC14_uc003egx.3_Missense_Mutation_p.D217V|CCDC14_uc010hrt.2_Missense_Mutation_p.D376V|CCDC14_uc003egy.3_Missense_Mutation_p.D217V|CCDC14_uc003egz.2_Missense_Mutation_p.D217V	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	417						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		CTTCTGTACATCCTTCACTGT	0.383		NA											29	157					0	0	0	0
CLSTN2	64084	broad.mit.edu	37	3	140251222	140251222	+	Silent	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:140251222C>A	uc003etn.2	+	9	1591	c.1401C>A	c.(1399-1401)ACC>ACA	p.T467T	CLSTN2_uc003etm.2_Silent_p.T467T	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	467	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTGTGGTAACCTTATACATGG	0.413		NA								HNSCC(16;0.037)			17	124					5.35e-07	1.16e-05	1	0
TNIK	23043	broad.mit.edu	37	3	170858204	170858204	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:170858204C>A	uc003fhh.2	-	13	1661	c.1316G>T	c.(1315-1317)CGT>CTT	p.R439L	TNIK_uc003fhi.2_Missense_Mutation_p.R439L|TNIK_uc003fhj.2_Missense_Mutation_p.R439L|TNIK_uc003fhk.2_Missense_Mutation_p.R439L|TNIK_uc003fhl.2_Missense_Mutation_p.R439L|TNIK_uc003fhm.2_Missense_Mutation_p.R439L|TNIK_uc003fhn.2_Missense_Mutation_p.R439L|TNIK_uc003fho.2_Missense_Mutation_p.R439L	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	439	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ATGCTCCGCACGCCTCCTCTC	0.652		NA											30	112					6.06e-23	1.4e-21	1	0
PIK3CA	5290	broad.mit.edu	37	3	178948153	178948153	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:178948153A>T	uc003fjk.2	+	20	3082	c.2925A>T	c.(2923-2925)AGA>AGT	p.R975S		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	975	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CAAAGACAAGAGAATTTGAGA	0.323		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	245					0	0	0	0
TTC14	151613	broad.mit.edu	37	3	180321093	180321093	+	Silent	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:180321093A>T	uc003fkk.2	+	3	600	c.468A>T	c.(466-468)ATA>ATT	p.I156I	TTC14_uc003fkl.2_Silent_p.I156I|TTC14_uc003fkm.2_Silent_p.I156I	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	156	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGAGAGATATAGCCCACTTAG	0.358		NA											16	170					0	0	0	0
MASP1	5648	broad.mit.edu	37	3	186968049	186968050	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:186968049_186968050GG>TT	uc003frh.1	-	8	1411_1412	c.1079_1080CC>AA	c.(1078-1080)CCC>CAA	p.P360Q	MASP1_uc003fri.2_Missense_Mutation_p.P360Q|MASP1_uc003frj.2_Missense_Mutation_p.P329Q|MASP1_uc003frk.1_Missense_Mutation_p.P360Q|MASP1_uc011bse.1_Missense_Mutation_p.P334Q	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	360	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTTTACAGGTGGGAATCTTGTT	0.287		NA											11	260					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193166098	193166098	+	Silent	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:193166098C>G	uc003ftd.2	-	18	2157	c.2049G>C	c.(2047-2049)CTG>CTC	p.L683L	ATP13A4_uc003fte.1_Silent_p.L683L|ATP13A4_uc011bsr.1_Silent_p.L154L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	683	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCAGAAATATCAGGTCTGATT	0.348		NA											33	97					0	0	0	0
C3orf43	255798	broad.mit.edu	37	3	196235135	196235135	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:196235135G>C	uc003fws.2	-	3	425	c.268C>G	c.(268-270)CGT>GGT	p.R90G	C3orf43_uc003fwr.2_Missense_Mutation_p.R82G	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	90						integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		TCAAGCACACGAGTATGCAAG	0.423		NA											6	200					0	0	0	0
C4orf23	152992	broad.mit.edu	37	4	8469757	8469757	+	Nonsense_Mutation	SNP	G	G	A	rs35357682	byFrequency	TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:8469757G>A	uc003glg.1	+	9	1112	c.924G>A	c.(922-924)TGG>TGA	p.W308*	C4orf23_uc003glf.1_Nonsense_Mutation_p.W296*|C4orf23_uc003glh.1_Nonsense_Mutation_p.W145*	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	537					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						CACCTGGCTGGGAGCTTTCCC	0.587		NA											4	16					0	0	0	0
LDB2	9079	broad.mit.edu	37	4	16760797	16760797	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:16760797A>G	uc003goz.2	-	2	535	c.219T>C	c.(217-219)GAT>GAC	p.D73D	LDB2_uc003gpa.2_Silent_p.D73D|LDB2_uc003gpb.2_Silent_p.D73D|LDB2_uc011bxh.1_Silent_p.D73D|LDB2_uc010iee.2_Silent_p.D73D	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	73							LIM domain binding|transcription cofactor activity				0						GCTTTGGTCCATCTTCCAAAC	0.418		NA											11	52					0	0	0	0
INTS12	57117	broad.mit.edu	37	4	106621142	106621142	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:106621142C>A	uc003hxw.2	-	3	279	c.21G>T	c.(19-21)TTG>TTT	p.L7F	INTS12_uc010ilr.2_Missense_Mutation_p.L7F	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	7					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GATCAAGTTCCAAGTTCACAG	0.358		NA											10	168					0.000151284	0.00295811	1	0
PCDH10	57575	broad.mit.edu	37	4	134072296	134072296	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:134072296G>T	uc003iha.2	+	1	1827	c.1001G>T	c.(1000-1002)GGC>GTC	p.G334V	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.G334V	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	334	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AAGGACCTGGGCCCCAACGCC	0.597		NA											11	40					3.86e-05	0.000775281	1	0
MTNR1A	4543	broad.mit.edu	37	4	187455231	187455231	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:187455231T>A	uc003izd.1	-	2	683	c.665A>T	c.(664-666)AAA>ATA	p.K222I		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	222	Cytoplasmic (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GCGGTCAGGTTTCACCCTCTG	0.478		NA											14	78					0	0	0	0
SPEF2	79925	broad.mit.edu	37	5	35641632	35641632	+	Silent	SNP	A	A	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:35641632A>C	uc003jjo.2	+	3	372	c.261A>C	c.(259-261)ACA>ACC	p.T87T	SPEF2_uc003jjn.1_Silent_p.T87T|SPEF2_uc003jjq.3_Silent_p.T87T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	87	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATCATCACAGAAAAGCCTG	0.438		NA											10	83					0	0	0	0
LMBRD2	92255	broad.mit.edu	37	5	36141228	36141228	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:36141228T>C	uc003jkb.1	-	4	764	c.349A>G	c.(349-351)ACG>GCG	p.T117A		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	117	Helical; (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATTGTGACGTCCAATACACT	0.313		NA											30	103					0	0	0	0
HEATR7B2	133558	broad.mit.edu	37	5	40999824	40999824	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:40999824T>G	uc003jmj.3	-	40	5030	c.4540A>C	c.(4540-4542)ACC>CCC	p.T1514P	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T1069P	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1514							binding			ovary(6)|central_nervous_system(2)	8						CAGGTGCTGGTGAAGAAGGTG	0.468		NA											3	63					0	0	0	0
RNF180	285671	broad.mit.edu	37	5	63509383	63509383	+	Splice_Site	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:63509383A>T	uc003jti.2	+	4	342	c.232_splice	c.e4-2	p.A78_splice	RNF180_uc003jth.3_Splice_Site_p.A78_splice|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1							integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		TATTACCTGTAGGCCCAGTGG	0.398		NA											28	107					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90004696	90004696	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:90004696G>T	uc003kju.2	+	39	8890	c.8794G>T	c.(8794-8796)GCT>TCT	p.A2932S	GPR98_uc003kjt.2_Missense_Mutation_p.A638S|GPR98_uc003kjv.2_Missense_Mutation_p.A532S	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2932	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTTACCATGGCTGCTTCAAC	0.343		NA											32	52					6.06e-23	1.4e-21	1	0
SLC22A5	6584	broad.mit.edu	37	5	131714117	131714117	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:131714117C>T	uc003kww.3	+	2	705	c.441C>T	c.(439-441)TCC>TCT	p.S147S	SLC22A5_uc003kwx.3_Silent_p.S171S	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	147	Helical; Name=2; (Potential).				positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TCACAATCTCCTTGTTCTTCG	0.507		NA											18	117					0	0	0	0
CXXC5	51523	broad.mit.edu	37	5	139060331	139060331	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:139060331C>T	uc010jfg.1	+	2	513	c.223C>T	c.(223-225)CGC>TGC	p.R75C	CXXC5_uc003let.2_Missense_Mutation_p.R75C	NM_016463	NP_057547	Q7LFL8	CXXC5_HUMAN	CXXC finger 5	75					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGCGCCGCTCCCGCCC	0.647		NA											7	24					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202711	140202711	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140202711G>A	uc003lhl.2	+	1	1351	c.1351G>A	c.(1351-1353)GCT>ACT	p.A451T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A451T|PCDHA5_uc003lhj.1_Missense_Mutation_p.A451T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	451	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACAACGCTCCGGCGTT	0.667		NA											11	23					0	0	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216085	140216085	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140216085C>T	uc003lhq.2	+	1	2117	c.2117C>T	c.(2116-2118)GCG>GTG	p.A706V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A706V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	706	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCATCTGCGCGGTGTCCAGT	0.617		NA											7	19					0	0	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216146	140216146	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140216146G>A	uc003lhq.2	+	1	2178	c.2178G>A	c.(2176-2178)CCG>CCA	p.P726P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.P726P	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	726	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAGCGCCGTCCTCTGAGG	0.612		NA											11	16					0	0	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250594	140250594	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140250594C>A	uc003lia.2	+	1	2764	c.1906C>A	c.(1906-1908)CTG>ATG	p.L636M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.L636M	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	636	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCGTGCCCTGGACGAGGC	0.662		NA											6	23					3.6e-05	0.000728797	1	0
PCDHB11	56125	broad.mit.edu	37	5	140579439	140579439	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140579439G>A	uc003liy.2	+	1	92	c.92G>A	c.(91-93)TGG>TAG	p.W31*	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	31	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGAAACCTGGAGCTTTTCT	0.527		NA											7	29					0	0	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735676	140735676	+	Silent	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140735676A>T	uc003ljq.1	+	1	909	c.909A>T	c.(907-909)ATA>ATT	p.I303I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.I303I	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	303	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATAACAATATTGGGGGGTC	0.443		NA											5	18					0	0	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788007	140788007	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140788007G>C	uc003lkj.1	+	1	238	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.E80Q	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	80	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTAGACGCGGAGAGCGGGGA	0.537		NA											18	34					0	0	0	0
STK32A	202374	broad.mit.edu	37	5	146752790	146752790	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:146752790C>A	uc010jgn.1	+	10	1116	c.836C>A	c.(835-837)CCG>CAG	p.P279Q	STK32A_uc003lom.2_Missense_Mutation_p.P279Q|STK32A_uc011dbw.1_Missense_Mutation_p.P279Q	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	279	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAACTTCCCGTATATGAAT	0.378		NA											7	90					0.000157383	0.0030423	1	0
LARP1	23367	broad.mit.edu	37	5	154179306	154179306	+	Silent	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:154179306C>T	uc003lvp.2	+	9	1962	c.1533C>T	c.(1531-1533)TAC>TAT	p.Y511Y	LARP1_uc003lvo.2_Silent_p.Y434Y|LARP1_uc010jie.1_Silent_p.Y306Y	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	511							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTCAGCACTACCAAAAGGAGA	0.527		NA											18	26					0	0	0	0
KIF4B	285643	broad.mit.edu	37	5	154394225	154394225	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:154394225G>A	uc010jih.1	+	1	966	c.806G>A	c.(805-807)TGC>TAC	p.C269Y		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	269	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGCCTCCTATGCTTGGGAAAT	0.443		NA											15	58					0	0	0	0
HAVCR1	26762	broad.mit.edu	37	5	156469687	156469687	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:156469687T>C	uc010jij.1	-	6	973	c.788A>G	c.(787-789)AAT>AGT	p.N263S	HAVCR1_uc011ddl.1_Missense_Mutation_p.N94S|HAVCR1_uc003lwi.2_Missense_Mutation_p.N263S	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	258	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACGGTGTCATTCCCATCTAC	0.353		NA											16	83					0	0	0	0
UBTD2	92181	broad.mit.edu	37	5	171639129	171639129	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:171639129T>C	uc003mbp.1	-	3	536	c.410A>G	c.(409-411)GAG>GGG	p.E137G		NM_152277	NP_689490	Q8WUN7	UBTD2_HUMAN	dendritic cell-derived ubiquitin-like protein	137						cytoplasm					0	Renal(175;0.000159)|Lung NSC(126;0.00976)|all_lung(126;0.0156)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCCAGAGTCTCTATGTCGCT	0.488		NA											32	29					0	0	0	0
NKAPL	222698	broad.mit.edu	37	6	28227756	28227756	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:28227756G>C	uc003nkt.2	+	1	659	c.607G>C	c.(607-609)GAT>CAT	p.D203H	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	203	Lys-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						GAAATATTCTGATAGTGACAG	0.294		NA											19	51					0	0	0	0
C6orf204	387119	broad.mit.edu	37	6	118790380	118790380	+	Silent	SNP	T	T	C	rs77465615		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:118790380T>C	uc003pxz.1	-	12	2697	c.2109A>G	c.(2107-2109)AAA>AAG	p.K703K		NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	703						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		ATAGTGGCCGTTTGGAAAGAA	0.418		NA											30	99					0	0	0	0
STXBP5	134957	broad.mit.edu	37	6	147694921	147694921	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:147694921G>A	uc003qlz.2	+	26	3297	c.3136G>A	c.(3136-3138)GGA>AGA	p.G1046R	STXBP5_uc010khz.1_Missense_Mutation_p.G1010R|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.G701R	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	1046					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		ACCAAACAGGGGATTCTTTAA	0.348		NA											6	65					0	0	0	0
TFB1M	51106	broad.mit.edu	37	6	155632378	155632378	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:155632378C>A	uc003qqj.3	-	2	293	c.229G>T	c.(229-231)GAC>TAC	p.D77Y	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		TCAGCGACGTCGGCATTAAGA	0.438		NA											22	61					1.97e-08	4.41e-07	1	0
RBAK	57786	broad.mit.edu	37	7	5103754	5103754	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:5103754C>G	uc010kss.1	+	6	991	c.667C>G	c.(667-669)CAT>GAT	p.H223D	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.H223D	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	223	Required for interaction with RB1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TTTTATTGCTCATAAGAGAGC	0.348		NA											12	45					0	0	0	0
HDAC9	9734	broad.mit.edu	37	7	18687544	18687544	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:18687544C>T	uc003suh.2	+	9	1204	c.1163C>T	c.(1162-1164)CCC>CTC	p.P388L	HDAC9_uc003sue.2_Missense_Mutation_p.P388L|HDAC9_uc011jyd.1_Missense_Mutation_p.P388L|HDAC9_uc003sui.2_Missense_Mutation_p.P391L|HDAC9_uc003suj.2_Missense_Mutation_p.P347L|HDAC9_uc011jya.1_Missense_Mutation_p.P385L|HDAC9_uc003sua.1_Missense_Mutation_p.P366L|HDAC9_uc011jyb.1_Missense_Mutation_p.P344L|HDAC9_uc003sud.1_Missense_Mutation_p.P388L|HDAC9_uc011jyc.1_Missense_Mutation_p.P347L|HDAC9_uc003suf.1_Missense_Mutation_p.P419L|HDAC9_uc010kud.1_Missense_Mutation_p.P391L|HDAC9_uc011jye.1_Missense_Mutation_p.P360L|HDAC9_uc011jyf.1_Missense_Mutation_p.P311L|HDAC9_uc010kue.1_Missense_Mutation_p.P131L	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	388					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GGAAAGCCACCCAACAGCAGC	0.502		NA											4	8					0	0	0	0
NUPL2	11097	broad.mit.edu	37	7	23240136	23240136	+	Silent	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:23240136G>C	uc003svu.2	+	7	1303	c.1044G>C	c.(1042-1044)CCG>CCC	p.P348P	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Silent_p.P225P|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Silent_p.P225P|NUPL2_uc011jyx.1_Silent_p.P120P	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	348	Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						TTGGTAGTCCGGGCTCACATT	0.507		NA											4	95					0	0	0	0
SCRN1	9805	broad.mit.edu	37	7	29983623	29983623	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:29983623C>G	uc010kvp.2	-	3	718	c.514G>C	c.(514-516)GGG>CGG	p.G172R	SCRN1_uc011jzy.1_Missense_Mutation_p.G104R|SCRN1_uc003tak.2_Missense_Mutation_p.G172R|SCRN1_uc011jzz.1_Missense_Mutation_p.G172R|SCRN1_uc011kaa.1_Missense_Mutation_p.G192R|SCRN1_uc011jzw.1_Missense_Mutation_p.G104R|SCRN1_uc011jzx.1_Intron	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	172					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						CAGTACTTCCCTATGGTCTCG	0.527		NA											7	45					0	0	0	0
YWHAG	7532	broad.mit.edu	37	7	75958917	75958917	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:75958917C>T	uc011kgj.1	-	2	938	c.721G>A	c.(721-723)GAT>AAT	p.D241N		NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan	241					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						TCGCCGCCATCGTCGTCCTGC	0.587		NA											8	8					0	0	0	0
SEMA3E	9723	broad.mit.edu	37	7	83035320	83035320	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:83035320G>C	uc003uhy.1	-	8	1335	c.869C>G	c.(868-870)GCG>GGG	p.A290G		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	290	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AACGAGTCTCGCTTTTAGGAA	0.348		NA											6	154					0	0	0	0
ABCB4	5244	broad.mit.edu	37	7	87069700	87069700	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:87069700C>A	uc003uiv.1	-	13	1451	c.1375G>T	c.(1375-1377)GAT>TAT	p.D459Y	ABCB4_uc003uiw.1_Missense_Mutation_p.D459Y|ABCB4_uc003uix.1_Missense_Mutation_p.D459Y	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	459	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCCTAATATCCTGCCCATCA	0.348		NA											9	46					5.69e-11	1.28e-09	1	0
MUC17	140453	broad.mit.edu	37	7	100681270	100681270	+	Silent	SNP	T	T	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:100681270T>C	uc003uxp.1	+	3	6626	c.6573T>C	c.(6571-6573)CCT>CCC	p.P2191P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2191	Extracellular (Potential).|35.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGCACACCTGTGACCAATT	0.483		NA											21	192					0	0	0	0
LRRC17	10234	broad.mit.edu	37	7	102574878	102574878	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:102574878C>T	uc003vau.2	+	2	907	c.518C>T	c.(517-519)ACG>ATG	p.T173M	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.T173M	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	173	LRRCT 1.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						GAGATAGAAACGCTTATTTCA	0.433		NA											12	103					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103207105	103207105	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:103207105G>C	uc003vca.2	-	32	4850	c.4690C>G	c.(4690-4692)CTG>GTG	p.L1564V	RELN_uc010liz.2_Missense_Mutation_p.L1564V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1564					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCTGTGGCAGGTCAATGGAA	0.473		NA											7	41					0	0	0	0
C7orf58	79974	broad.mit.edu	37	7	120629688	120629688	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:120629688C>G	uc003vjq.3	+	2	460	c.13C>G	c.(13-15)CCA>GCA	p.P5A	C7orf58_uc003vjr.1_Missense_Mutation_p.P5A|C7orf58_uc003vjs.3_Missense_Mutation_p.P5A	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	5						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GGTCTGTCGCCCAGTGTTCCC	0.522		NA											10	59					0	0	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121701229	121701229	+	Silent	SNP	A	A	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:121701229A>C	uc003vjy.2	+	30	7298	c.6903A>C	c.(6901-6903)GCA>GCC	p.A2301A	PTPRZ1_uc003vjz.2_Silent_p.A1434A|PTPRZ1_uc011knt.1_Silent_p.A891A	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2301	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATGGTGCAGCATTGCCTGATG	0.448		NA											24	38					0	0	0	0
IQUB	154865	broad.mit.edu	37	7	123097503	123097503	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:123097503G>A	uc003vkn.2	-	12	2702	c.2125C>T	c.(2125-2127)CCC>TCC	p.P709S	IQUB_uc011kny.1_Missense_Mutation_p.P42S|IQUB_uc003vko.2_Missense_Mutation_p.P709S|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	709										ovary(3)|large_intestine(1)	4						CAGTTCCAGGGGGACCACTCC	0.453		NA											18	96					0	0	0	0
FLNC	2318	broad.mit.edu	37	7	128492757	128492757	+	Silent	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:128492757G>A	uc003vnz.3	+	36	6164	c.5955G>A	c.(5953-5955)TCG>TCA	p.S1985S	FLNC_uc003voa.3_Silent_p.S1952S	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1985	Filamin 18.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GTGCCCCCTCGGGCAACGAGG	0.657		NA											6	22					0	0	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147183067	147183067	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:147183067C>G	uc003weu.1	+	11	2227	c.1711C>G	c.(1711-1713)CAA>GAA	p.Q571E		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	571	EGF-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGTGCTCGCAAACATGGGA	0.443		NA								HNSCC(39;0.1)			17	77					0	0	0	0
AMAC1L2	83650	broad.mit.edu	37	8	11189001	11189001	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:11189001A>G	uc003wtp.1	+	1	507	c.386A>G	c.(385-387)AAC>AGC	p.N129S		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	129	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CCCGCTGGCAACGCTGCCACT	0.612		NA											13	57					0	0	0	0
TUSC3	7991	broad.mit.edu	37	8	15519695	15519695	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:15519695G>T	uc003wwt.2	+	5	808	c.598G>T	c.(598-600)GGT>TGT	p.G200C	TUSC3_uc003wwr.2_Missense_Mutation_p.G200C|TUSC3_uc003wws.2_Missense_Mutation_p.G200C|TUSC3_uc003wwu.2_Missense_Mutation_p.G200C|TUSC3_uc003wwv.2_Missense_Mutation_p.G200C|TUSC3_uc003www.2_Missense_Mutation_p.G200C|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.G200C	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	200	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		CAACTACTCTGGTACCATTGC	0.368		NA											8	117					0.000274275	0.00521276	1	0
HMBOX1	79618	broad.mit.edu	37	8	28906499	28906499	+	Silent	SNP	A	A	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:28906499A>T	uc003xhd.3	+	9	1401	c.1059A>T	c.(1057-1059)ATA>ATT	p.I353I	HMBOX1_uc010lvd.2_Silent_p.I353I|HMBOX1_uc003xhc.3_Silent_p.I352I|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Silent_p.I353I|HMBOX1_uc011lay.1_Silent_p.I352I|HMBOX1_uc003xhf.2_Silent_p.I339I|HMBOX1_uc003xhg.2_Silent_p.I340I	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	353					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		GTCATGGGATAGATGTGCAGA	0.473		NA											13	127					0	0	0	0
ARMC1	55156	broad.mit.edu	37	8	66525539	66525539	+	Silent	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:66525539C>A	uc003xvl.2	-	4	640	c.405G>T	c.(403-405)CTG>CTT	p.L135L	ARMC1_uc011leo.1_Intron	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	135					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			TTGTAGTTCCCAGAAAAAATT	0.393		NA											8	128					0.000442599	0.00827283	1	0
PEX2	5828	broad.mit.edu	37	8	77896369	77896369	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:77896369T>A	uc003yax.2	-	4	504	c.46A>T	c.(46-48)AGA>TGA	p.R16*	PEX2_uc003yay.2_Nonsense_Mutation_p.R16*|PEX2_uc003yaz.2_Nonsense_Mutation_p.R16*	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	16					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						TGGCTTATTCTTAGCACTCTG	0.423		NA											14	104					0	0	0	0
ZNF7	7553	broad.mit.edu	37	8	146068464	146068465	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:146068464_146068465GG>TT	uc003zeg.3	+	5	2109_2110	c.1972_1973GG>TT	c.(1972-1974)GGG>TTG	p.G658L	ZNF7_uc010mge.2_Missense_Mutation_p.G669L|ZNF7_uc011lln.1_Missense_Mutation_p.G562L|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.G562L|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	658					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		AATTCACACCGGGGAGAAGCCT	0.386		NA											7	116					0	0	0	0
NFIB	4781	broad.mit.edu	37	9	14146797	14146797	+	Silent	SNP	G	G	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:14146797G>T	uc003zle.2	-	6	1251	c.816C>A	c.(814-816)CCC>CCA	p.P272P	NFIB_uc003zld.2_Silent_p.P20P|NFIB_uc003zlf.2_Silent_p.P272P|NFIB_uc011lmo.1_Silent_p.P272P	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	272					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ATATAGTTTTGGGTCTTTTGC	0.378		NA	T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								10	223					0.00010058	0.00197235	1	0
ELAVL2	1993	broad.mit.edu	37	9	23704954	23704954	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:23704954C>G	uc003zpu.2	-	4	724	c.449G>C	c.(448-450)CGC>CCC	p.R150P	ELAVL2_uc003zps.2_Missense_Mutation_p.R150P|ELAVL2_uc003zpt.2_Missense_Mutation_p.R150P|ELAVL2_uc003zpv.2_Missense_Mutation_p.R150P|ELAVL2_uc003zpw.2_Missense_Mutation_p.R150P	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	150	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		AGTAATAATGCGTCCATATTG	0.423		NA											9	120					0	0	0	0
PLAA	9373	broad.mit.edu	37	9	26905576	26905576	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:26905576T>A	uc003zqd.2	-	14	2746	c.2321A>T	c.(2320-2322)AAG>ATG	p.K774M		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	774	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TGAGGAATACTTTTTTATTTG	0.368		NA											24	98					0	0	0	0
ZNF189	7743	broad.mit.edu	37	9	104170995	104170995	+	Silent	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:104170995C>A	uc004bbh.1	+	3	1221	c.945C>A	c.(943-945)CCC>CCA	p.P315P	ZNF189_uc004bbg.1_Silent_p.P273P|ZNF189_uc004bbi.1_Silent_p.P301P|ZNF189_uc011lvk.1_Silent_p.P300P	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	315					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				GGGAAAGACCCCATAAATGTG	0.393		NA											9	136					0.000442599	0.00827283	1	0
CEP110	11064	broad.mit.edu	37	9	123911032	123911032	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:123911032G>A	uc004bkx.1	+	22	3573	c.3542G>A	c.(3541-3543)CGC>CAC	p.R1181H	CEP110_uc004bky.1_Missense_Mutation_p.R785H|CEP110_uc004bla.1_Missense_Mutation_p.R629H|CEP110_uc010mvo.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1181					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AGAAAACCACGCCCTGGGCAG	0.512		NA											11	56					0	0	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132758	91132758	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:91132758C>A	uc004efk.1	+	2	2364	c.1519C>A	c.(1519-1521)CCT>ACT	p.P507T	PCDH11X_uc004efl.1_Missense_Mutation_p.P507T|PCDH11X_uc004efo.1_Missense_Mutation_p.P507T|PCDH11X_uc010nmv.1_Missense_Mutation_p.P507T|PCDH11X_uc004efm.1_Missense_Mutation_p.P507T|PCDH11X_uc004efn.1_Missense_Mutation_p.P507T|PCDH11X_uc004efh.1_Missense_Mutation_p.P507T|PCDH11X_uc004efj.1_Missense_Mutation_p.P507T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	507	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CCTGCTAGGCCCTGATGCTCC	0.423		NA											12	10					1.09e-07	2.37e-06	1	0
GPRASP2	114928	broad.mit.edu	37	X	101969805	101969805	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:101969805G>C	uc004ejk.2	+	4	1342	c.8G>C	c.(7-9)GGG>GCG	p.G3A	GPRASP2_uc004ejl.2_Missense_Mutation_p.G3A|GPRASP2_uc004ejm.2_Missense_Mutation_p.G3A|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	3						cytoplasm	protein binding			ovary(1)	1						accatgactGGGGCAGAGATT	0.294		NA											3	39					0	0	0	0
CHRDL1	91851	broad.mit.edu	37	X	109919483	109919483	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:109919483C>A	uc004eou.3	-	12	1702	c.1353G>T	c.(1351-1353)GAG>GAT	p.E451D	CHRDL1_uc004eov.2_Missense_Mutation_p.E440D|CHRDL1_uc004eow.2_Missense_Mutation_p.E449D|CHRDL1_uc010nps.2_Missense_Mutation_p.E450D|CHRDL1_uc004eot.2_Missense_Mutation_p.E370D|CHRDL1_uc011mss.1_Missense_Mutation_p.E365D	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	443					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						TTTCAGATCTCTCCAGGTACA	0.448		NA											29	44					2.46e-21	5.68e-20	1	0
SAGE1	55511	broad.mit.edu	37	X	134994090	134994090	+	Silent	SNP	A	A	G			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:134994090A>G	uc004ezh.2	+	18	2666	c.2499A>G	c.(2497-2499)AAA>AAG	p.K833K	SAGE1_uc010nry.1_Silent_p.K802K|SAGE1_uc011mvv.1_Silent_p.K457K	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	833										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AATTAATGAAAGAAGTTCGAA	0.348		NA											14	61					0	0	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:74575212_74575213insT	uc001dfy.3	-	5	924_925	c.732_733insA	c.(730-735)AAACAGfs	p.K244fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	244_245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						ovary(2)	2						TTTTCCTGCTGTTTTTTTTTGT	0.327		NA											7	134	---	---	---	---	NA	NA	NA	NA
UPF2	26019	broad.mit.edu	37	10	12001252	12001253	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:12001252_12001253insT	uc001ila.2	-	11	2761_2762	c.2287_2288insA	c.(2287-2289)ACCfs	p.T763fs	UPF2_uc001ilb.2_Frame_Shift_Ins_p.T763fs|UPF2_uc001ilc.2_Frame_Shift_Ins_p.T763fs|UPF2_uc009xiz.1_Frame_Shift_Ins_p.T763fs	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	763	Sufficient for interaction with UPF3A and UPF3B.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				CTTTTTCACGGTTTTTTCAGCT	0.416		NA											17	116	---	---	---	---	NA	NA	NA	NA
SOCS7	30837	broad.mit.edu	37	17	36508743	36508743	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:36508743delC	uc002hqa.2	+	1	739	c.616delC	c.(616-618)CGGfs	p.R206fs	SOCS7_uc010cvl.2_Frame_Shift_Del_p.R206fs|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	206	Mediates interaction with SORBS3.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					GGGTCCTTCTCGGAAGGGCTC	0.617		NA											2	4	---	---	---	---	NA	NA	NA	NA
SIN3B	23309	broad.mit.edu	37	19	16977273	16977273	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:16977273delC	uc002ney.1	+	13	1822	c.1808delC	c.(1807-1809)TCCfs	p.S603fs	SIN3B_uc002nez.1_Frame_Shift_Del_p.S571fs|SIN3B_uc010xpi.1_Frame_Shift_Del_p.S161fs	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	603					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						TACCTCAAGTCCCTTGACCAC	0.587		NA											8	26	---	---	---	---	NA	NA	NA	NA
SEMA3F	6405	broad.mit.edu	37	3	50212549	50212549	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:50212549delT	uc003cyj.2	+	6	675	c.477delT	c.(475-477)ACTfs	p.T159fs	SEMA3F_uc003cyk.2_Intron	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	159	Sema.			Missing (in Ref. 2).	axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GGACCCAGACTCAGGCGGTCA	0.697		NA											2	4	---	---	---	---	NA	NA	NA	NA
CDKL2	8999	broad.mit.edu	37	4	76539579	76539580	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:76539579_76539580insT	uc003hiq.2	-	3	747_748	c.222_223insA	c.(220-225)AAACGAfs	p.K74fs	CDKL2_uc011cbp.1_Frame_Shift_Ins_p.K74fs|CDKL2_uc010iix.1_Intron	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	74_75	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AGGTACCATCGTTTTTTTTTCT	0.322		NA											7	301	---	---	---	---	NA	NA	NA	NA
FABP6	2172	broad.mit.edu	37	5	159659192	159659192	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:159659192delA	uc003lya.1	+	2	283	c.155delA	c.(154-156)CAGfs	p.Q52fs	FABP6_uc003lxx.1_Frame_Shift_Del_p.Q101fs|FABP6_uc003lxz.1_Frame_Shift_Del_p.Q101fs	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	52					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTTGGTCCCAGCACTACTCC	0.567		NA											2	4	---	---	---	---	NA	NA	NA	NA