Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PER3	8863	broad.mit.edu	37	1	7880227	7880227	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:7880227A>T	uc001aoo.2	+	14	1862	c.1687A>T	c.(1687-1689)ACA>TCA	p.T563S	PER3_uc009vmg.1_Missense_Mutation_p.T571S|PER3_uc009vmh.1_Missense_Mutation_p.T564S|PER3_uc001aop.2_Missense_Mutation_p.T571S|PER3_uc010nzw.1_Missense_Mutation_p.T252S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	563	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TATCTCCTGTACAAATACAAC	0.398		NA											5	59					0	0	0	0
ASH1L	55870	broad.mit.edu	37	1	155319129	155319129	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:155319129G>A	uc009wqq.2	-	19	8038	c.7558C>T	c.(7558-7560)CGG>TGG	p.R2520W	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.R2515W|MIR555_hsa-mir-555|MI0003561_5'Flank	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2520	Bromo.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TCAGCATTCCGAAAGACTTTG	0.383		NA											7	57					0	0	0	0
HKDC1	80201	broad.mit.edu	37	10	71003038	71003038	+	Silent	SNP	C	C	T	rs138098227		TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr10:71003038C>T	uc001jpf.3	+	7	925	c.792C>T	c.(790-792)TTC>TTT	p.F264F	HKDC1_uc010qje.1_Silent_p.F127F	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	264					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						GGGGGGCCTTCGGGGACGACG	0.592		NA											5	87					0	0	0	0
TAF10	6881	broad.mit.edu	37	11	6632457	6632457	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:6632457T>C	uc001mej.1	-	4	555	c.530A>G	c.(529-531)AAG>AGG	p.K177R		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	177					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGCCGTGCCCTTCATTTTGCA	0.488		NA											5	64					0	0	0	0
TAS2R30	259293	broad.mit.edu	37	12	11286073	11286073	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:11286073C>A	uc009zhs.1	-	1	771	c.771G>T	c.(769-771)AAG>AAT	p.K257N	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0						AGACAGGTTGCTTTTCCAGCC	0.388		NA											12	116					1.58e-08	1.75e-08	1	0
EID3	493861	broad.mit.edu	37	12	104698633	104698633	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:104698633A>G	uc001tkw.2	+	1	1085	c.921A>G	c.(919-921)ATA>ATG	p.I307M	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						AGGGAGTTATATCTTTGACTT	0.398		NA											10	63					0	0	0	0
EPSTI1	94240	broad.mit.edu	37	13	43500540	43500540	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr13:43500540G>T	uc001uyw.1	-	7	665	c.589C>A	c.(589-591)CTG>ATG	p.L197M	EPSTI1_uc001uyx.1_Missense_Mutation_p.L197M	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	197										ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TCTGTGTTCAGTTTGCTCAAG	0.428		NA											12	170					0.00010058	0.000108775	1	0
PRKD1	5587	broad.mit.edu	37	14	30100144	30100144	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:30100144G>A	uc001wqh.2	-	10	1657	c.1476C>T	c.(1474-1476)TTC>TTT	p.F492F		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	492	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TAGTGATTTCGAAACAATGAG	0.398		NA											7	80					0	0	0	0
SERPINA12	145264	broad.mit.edu	37	14	94956062	94956062	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:94956062G>A	uc001ydj.2	-	5	1744	c.948C>T	c.(946-948)ACC>ACT	p.T316T		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	316					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		TCAGGTCGAAGGTGCCCGTCA	0.532		NA											5	50					0	0	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499318	59499318	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr15:59499318G>A	uc002agb.2	+	1	277	c.179G>A	c.(178-180)CGT>CAT	p.R60H	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	60					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	CTTATTGAGCGTTTCACTTCC	0.552		NA											5	78					0	0	0	0
PMFBP1	83449	broad.mit.edu	37	16	72159281	72159281	+	Silent	SNP	T	T	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:72159281T>G	uc002fcc.3	-	16	2464	c.2292A>C	c.(2290-2292)ACA>ACC	p.T764T	PMFBP1_uc002fcd.2_Silent_p.T759T|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.T614T|PMFBP1_uc010cgo.1_Silent_p.T55T	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	764	Potential.									ovary(2)	2		Ovarian(137;0.179)				GCAGGCTCTTTGTCTCTGAGG	0.483		NA									OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	170					0	0	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76556036	76556036	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:76556036G>A	uc002feu.1	+	19	3022	c.2637G>A	c.(2635-2637)GTG>GTA	p.V879V	CNTNAP4_uc002fev.1_Silent_p.V743V|CNTNAP4_uc010chb.1_Silent_p.V806V|CNTNAP4_uc002fex.1_Silent_p.V882V	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	879	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GGCACCATGTGAGGGTTGAAA	0.527		NA											6	120					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr17:7578457C>A	uc002gim.2	-	5	667	c.473G>T	c.(472-474)CGC>CTC	p.R158L	TP53_uc002gig.1_Missense_Mutation_p.R158L|TP53_uc002gih.2_Missense_Mutation_p.R158L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26L|TP53_uc010cng.1_Missense_Mutation_p.R26L|TP53_uc002gii.1_Missense_Mutation_p.R26L|TP53_uc010cnh.1_Missense_Mutation_p.R158L|TP53_uc010cni.1_Missense_Mutation_p.R158L|TP53_uc002gij.2_Missense_Mutation_p.R158L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65L|TP53_uc002gio.2_Missense_Mutation_p.R26L|TP53_uc010vug.1_Missense_Mutation_p.R119L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	63					5.94e-07	6.52e-07	1	0
PGLYRP2	114770	broad.mit.edu	37	19	15587145	15587145	+	Silent	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr19:15587145C>T	uc002nbf.3	-	2	469	c.336G>A	c.(334-336)CTG>CTA	p.L112L	PGLYRP2_uc002nbg.3_Silent_p.L112L	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	112					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CATCAGGTGCCAGCACCACCC	0.617		NA											9	105					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33567941	33567941	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:33567941G>A	uc002ros.2	+	25	3770	c.3770G>A	c.(3769-3771)AGT>AAT	p.S1257N	LTBP1_uc002rot.2_Missense_Mutation_p.S931N|LTBP1_uc002rou.2_Missense_Mutation_p.S930N|LTBP1_uc002rov.2_Missense_Mutation_p.S877N|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1256	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTTTGTGACAGTCACGGGTTT	0.443		NA											6	46					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141243044	141243044	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:141243044C>T	uc002tvj.1	-	59	10265	c.9293G>A	c.(9292-9294)GGA>GAA	p.G3098E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3098	Extracellular (Potential).|LDL-receptor class B 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGGTTTTTTCCAATCCAATC	0.373		NA								TSP Lung(27;0.18)			5	35					0	0	0	0
CCDC148	130940	broad.mit.edu	37	2	159170404	159170404	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:159170404T>C	uc002tzq.2	-	8	1030	c.767A>G	c.(766-768)AAC>AGC	p.N256S	CCDC148_uc002tzr.2_Missense_Mutation_p.N104S|CCDC148_uc010foh.2_5'UTR|CCDC148_uc010foi.1_Missense_Mutation_p.N203S|CCDC148_uc010foj.1_Missense_Mutation_p.N104S|CCDC148_uc010fok.1_Missense_Mutation_p.N170S	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	256										ovary(2)	2						TAGTTGACAGTTTCTAGAAGC	0.388		NA											4	46					0	0	0	0
CACNA1I	8911	broad.mit.edu	37	22	40059771	40059771	+	Silent	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr22:40059771C>T	uc003ayc.2	+	19	3522	c.3522C>T	c.(3520-3522)TAC>TAT	p.Y1174Y	CACNA1I_uc003ayd.2_Silent_p.Y1139Y|CACNA1I_uc003aye.2_Silent_p.Y1089Y|CACNA1I_uc003ayf.2_Silent_p.Y1054Y	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1174	Helical; Name=S1 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCTTCGACTACGTCGTCCTGG	0.632		NA											9	96					0	0	0	0
XIRP1	165904	broad.mit.edu	37	3	39230859	39230859	+	Silent	SNP	T	T	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:39230859T>G	uc003cjk.1	-	2	299	c.78A>C	c.(76-78)CCA>CCC	p.P26P	XIRP1_uc003cji.2_Silent_p.P26P|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	26	Interaction with VASP.|Poly-Pro.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGCTGGGGGTGGAGGGAGGG	0.637		NA											5	13					0	0	0	0
WDR82	80335	broad.mit.edu	37	3	52304734	52304734	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:52304734T>C	uc003ddl.2	-	2	535	c.253A>G	c.(253-255)ATA>GTA	p.I85V	WDR82_uc003ddk.2_5'Flank|uc011bee.1_5'Flank|MIRLET7G_hsa-let-7g|MI0000433_5'Flank	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	85					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TTACCGTCTATTTTGTTAGAG	0.378		NA											7	134					0	0	0	0
KPNA4	3840	broad.mit.edu	37	3	160227623	160227623	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:160227623T>A	uc003fdn.2	-	14	1480	c.1174A>T	c.(1174-1176)ATA>TTA	p.I392L		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	392	ARM 8.|NLS binding site (minor) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AAGTTACTTATGGCCCAAGCA	0.318		NA											18	137					0	0	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186760908	186760908	+	Silent	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:186760908C>T	uc003frb.2	+	4	849	c.417C>T	c.(415-417)GCC>GCT	p.A139A	ST6GAL1_uc003frc.2_Intron|ST6GAL1_uc003frd.2_Silent_p.A139A	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	139	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTGCAGAGGCCCTGCGCTGCC	0.507		NA											8	52					0	0	0	0
OTOP1	133060	broad.mit.edu	37	4	4214642	4214642	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:4214642T>C	uc003ghp.1	-	2	523	c.493A>G	c.(493-495)ACT>GCT	p.T165A		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	165					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACTCCTTCAGTGGCTGATAAA	0.393		NA											5	61					0	0	0	0
GABRA2	2555	broad.mit.edu	37	4	46307679	46307679	+	Silent	SNP	A	A	G			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:46307679A>G	uc003gxc.3	-	6	1282	c.609T>C	c.(607-609)TCT>TCC	p.S203S	GABRA2_uc010igc.2_Silent_p.S203S|GABRA2_uc011bzc.1_Silent_p.S148S|GABRA2_uc003gxe.2_Silent_p.S203S	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	203	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTACTGAATCAGATGCATTGT	0.358		NA											4	63					0	0	0	0
CDC20B	166979	broad.mit.edu	37	5	54420729	54420729	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:54420729C>T	uc003jpo.1	-	9	1292	c.1117G>A	c.(1117-1119)GGC>AGC	p.G373S	CDC20B_uc003jpn.1_Missense_Mutation_p.G373S|CDC20B_uc010ivu.1_Missense_Mutation_p.G373S|CDC20B_uc010ivv.1_3'UTR	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	373	WD 4.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TCACTGCAGCCGCTGGAAAGC	0.567		NA											5	63					0	0	0	0
ZNF366	167465	broad.mit.edu	37	5	71739939	71739939	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:71739939C>T	uc003kce.1	-	5	2065	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGCTCCACCTCGTAGCAGTTA	0.667		NA											9	194					0	0	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182956	140182956	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:140182956C>A	uc003lhf.2	+	1	2174	c.2174C>A	c.(2173-2175)GCG>GAG	p.A725E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A725E	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGCTCCGCGCCGCCAACC	0.637		NA											9	129					0.00829132	0.00877197	1	0
LAMA4	3910	broad.mit.edu	37	6	112440499	112440499	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr6:112440499C>T	uc003pvu.2	-	34	4990	c.4681G>A	c.(4681-4683)GAA>AAA	p.E1561K	LAMA4_uc003pvv.2_Missense_Mutation_p.E1554K|LAMA4_uc003pvt.2_Missense_Mutation_p.E1554K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1561	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CTGCTCCTTTCTCGAATAAAT	0.438		NA											6	80					0	0	0	0
TTF1	7270	broad.mit.edu	37	9	135277018	135277018	+	Silent	SNP	G	G	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:135277018G>A	uc004cbl.2	-	2	1243	c.1191C>T	c.(1189-1191)GTC>GTT	p.V397V	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	397					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GTGCCCTTTTGACAGACGTAA	0.463		NA											6	94					0	0	0	0
C11orf48	79081	broad.mit.edu	37	11	62435132	62435134	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:62435132_62435134delTCT	uc001nue.2	-	4	834_836	c.399_401delAGA	c.(397-402)GAAGAT>GAT	p.E133del	C11orf48_uc001nuf.2_In_Frame_Del_p.E133del|METTL12_uc001nuh.2_3'UTR|C11orf48_uc010rmd.1_In_Frame_Del_p.E133del	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081	159											0						CCAACAAGCATCTTCTTCATCCT	0.537		NA											26	323	---	---	---	---	NA	NA	NA	NA
GPX2	2877	broad.mit.edu	37	14	65406461	65406462	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:65406461_65406462delCT	uc010tsn.1	-	3	404_405	c.317_318delAG	c.(316-318)GAGfs	p.E106fs	CHURC1_uc010tsj.1_Intron|CHURC1_uc010tsk.1_Intron|FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|GPX2_uc001xhy.1_RNA	NM_002083	NP_002074	P18283	GPX2_HUMAN	glutathione peroxidase 2	106					response to oxidative stress	cytoplasm	electron carrier activity|glutathione peroxidase activity			ovary(1)	1				all cancers(60;0.00117)|OV - Ovarian serous cystadenocarcinoma(108;0.00557)|BRCA - Breast invasive adenocarcinoma(234;0.00971)	Glutathione(DB00143)	GCCCATTCACCTCACATTTTTG	0.525		NA											7	80	---	---	---	---	NA	NA	NA	NA
AGBL1	123624	broad.mit.edu	37	15	86810224	86810224	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr15:86810224delT	uc002blz.1	+	12	1697	c.1617delT	c.(1615-1617)CCTfs	p.P539fs	AGBL1_uc002bma.1_Frame_Shift_Del_p.P270fs|AGBL1_uc002bmb.1_Frame_Shift_Del_p.P233fs	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	539					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATTGTAGGCCTTTGCAAGACA	0.323		NA											2	4	---	---	---	---	NA	NA	NA	NA
STK10	6793	broad.mit.edu	37	5	171488259	171488260	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:171488259_171488260delAC	uc003mbo.1	-	14	2395_2396	c.2095_2096delGT	c.(2095-2097)GTAfs	p.V699fs		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	699	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTGCTTGGCTACAAAGTCCCGG	0.584		NA											11	124	---	---	---	---	NA	NA	NA	NA
TMEM38B	55151	broad.mit.edu	37	9	108484899	108484900	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:108484899_108484900insA	uc004bcu.1	+	4	656_657	c.539_540insA	c.(538-540)TCAfs	p.S180fs	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	180	Lumenal (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						CTGAAGATGTCATAGTAAGTTG	0.342		NA											8	79	---	---	---	---	NA	NA	NA	NA