Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CDC20	991	broad.mit.edu	37	1	43825460	43825460	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:43825460G>C	uc001cix.2	+	4	496	c.395G>C	c.(394-396)CGG>CCG	p.R132P	CDC20_uc001ciy.2_Missense_Mutation_p.R132P	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	132				R->A: Loss of interaction with MAD2L1.	activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AAGATCCTTCGGCTCAGTGGA	0.502		NA											102	164					0	0	0	0
KIAA0467	23334	broad.mit.edu	37	1	43881682	43881682	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:43881682G>A	uc009vws.1	+	6	766	c.682G>A	c.(682-684)GTC>ATC	p.V228I				Q5T011	SZT2_HUMAN	Homo sapiens mRNA for KIAA0467 protein, partial cds.	228						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GAAGGTAGGCGTCTCCATGGT	0.552		NA											8	26					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44044587	44044587	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:44044587G>A	uc001cjr.2	+	7	1015	c.675G>A	c.(673-675)GTG>GTA	p.V225V	PTPRF_uc001cjq.3_Silent_p.V231V|PTPRF_uc001cjs.2_Silent_p.V225V|PTPRF_uc001cjt.3_Silent_p.V225V	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	225	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACCTGTATGTGCGAGGTAAGG	0.612		NA											3	39					0	0	0	0
LPPR4	9890	broad.mit.edu	37	1	99771805	99771805	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:99771805G>A	uc001dse.2	+	7	1637	c.1531G>A	c.(1531-1533)GGA>AGA	p.G511R	LPPR4_uc010oue.1_Missense_Mutation_p.G453R	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	511							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CGCTGTCCCCGGATGTAACAA	0.552		NA											17	384					0	0	0	0
AMIGO1	57463	broad.mit.edu	37	1	110051444	110051444	+	Missense_Mutation	SNP	C	C	T	rs139908524		TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:110051444C>T	uc001dxx.3	-	2	473	c.91G>A	c.(91-93)GTG>ATG	p.V31M		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	31	LRRNT.|Extracellular (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CAGCTAACCACGGCTCGGCCA	0.627		NA											11	29					0	0	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156950259	156950259	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:156950259G>A	uc001fqo.2	-	4	1283	c.243C>T	c.(241-243)GCC>GCT	p.A81A	ARHGEF11_uc001fqn.2_Silent_p.A81A	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	81	PDZ.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTTTCACACCGGCCTTCATGG	0.567		NA											5	11					0	0	0	0
ATP1A2	477	broad.mit.edu	37	1	160104995	160104995	+	Silent	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:160104995C>T	uc001fvc.2	+	15	2157	c.2025C>T	c.(2023-2025)CTC>CTT	p.L675L	ATP1A2_uc001fvb.2_Silent_p.L675L|ATP1A2_uc001fvd.2_Silent_p.L411L	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	675	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGGAGCAGCTCGATGAGATCC	0.577		NA											34	59					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525894	176525894	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:176525894G>A	uc001gkz.2	+	2	1600	c.436G>A	c.(436-438)GCT>ACT	p.A146T	PAPPA2_uc001gky.1_Missense_Mutation_p.A146T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	146					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGATGATGACGCTTATCTCGG	0.542		NA											6	209					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181745355	181745355	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:181745355G>A	uc001gow.2	+	38	5423	c.5258G>A	c.(5257-5259)CGA>CAA	p.R1753Q	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1641Q|CACNA1E_uc001gox.1_Missense_Mutation_p.R979Q|CACNA1E_uc009wxt.2_Missense_Mutation_p.R979Q	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1753	EF-hand.|By similarity.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAATATGACCGAGCAGCATGG	0.612		NA											6	168					0	0	0	0
CACNA1S	779	broad.mit.edu	37	1	201046135	201046135	+	Silent	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:201046135G>C	uc001gvv.2	-	12	1967	c.1740C>G	c.(1738-1740)CTC>CTG	p.L580L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	580	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCCCCCCAAAGAGCTGCATGC	0.473		NA											16	145					0	0	0	0
CHI3L1	1116	broad.mit.edu	37	1	203150383	203150383	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:203150383G>A	uc001gzi.2	-	7	789	c.618C>T	c.(616-618)TAC>TAT	p.Y206Y	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_Silent_p.Y3Y|CHI3L1_uc001gzj.2_Silent_p.Y206Y|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	206	Chitooligosaccharide.				chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						CATGAAAATCGTAGGTCATGA	0.458		NA											25	61					0	0	0	0
GREM2	64388	broad.mit.edu	37	1	240656560	240656560	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:240656560C>G	uc001hys.2	-	2	496	c.216G>C	c.(214-216)TGG>TGC	p.W72C		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	72					BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			GCGTCTTGCACCAGTCACTCT	0.632		NA											12	44					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	240966240	240966240	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:240966240G>A	uc001hyv.2	-	16	1653	c.1323C>T	c.(1321-1323)TCC>TCT	p.S441S	RGS7_uc010pyh.1_Silent_p.S415S|RGS7_uc010pyj.1_Silent_p.S357S|RGS7_uc001hyu.2_Silent_p.S441S|RGS7_uc009xgn.1_Silent_p.S388S|RGS7_uc001hyw.2_Silent_p.S441S|RGS7_uc001hyt.2_Silent_p.S273S	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	441	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GATAGGCACTGGATCTTATAA	0.348		NA											19	189					0	0	0	0
SLC39A12	221074	broad.mit.edu	37	10	18270411	18270411	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:18270411G>C	uc001ipo.2	+	6	1368	c.1095G>C	c.(1093-1095)GAG>GAC	p.E365D	SLC39A12_uc001ipn.2_Missense_Mutation_p.E365D|SLC39A12_uc001ipp.2_Missense_Mutation_p.E365D|SLC39A12_uc010qck.1_Missense_Mutation_p.E231D	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	365	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CCACTCTGGAGAGTAAGTTCT	0.393		NA											10	39					0	0	0	0
TET1	80312	broad.mit.edu	37	10	70405419	70405419	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:70405419C>G	uc001jok.3	+	4	3438	c.2933C>G	c.(2932-2934)TCC>TGC	p.S978C		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	978					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						ACTACCCTTTCCAACTCACAT	0.363		NA											17	72					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95790919	95790919	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:95790919C>G	uc001kjk.2	+	2	750	c.116C>G	c.(115-117)TCA>TGA	p.S39*	PLCE1_uc010qnx.1_Nonsense_Mutation_p.S39*	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	39					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATCAATATTTCAAAAGCACAT	0.423		NA											17	96					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	107012588	107012588	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:107012588C>A	uc001kyi.1	+	23	3388	c.3161C>A	c.(3160-3162)ACT>AAT	p.T1054N	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1054	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTCTCCCCACTTCAGCAGAG	0.517		NA											30	69					2.5e-24	3.02e-24	1	0
MUC5B	727897	broad.mit.edu	37	11	1275954	1275954	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:1275954G>A	uc009ycr.1	+	57	16645	c.16519G>A	c.(16519-16521)GGT>AGT	p.G5507S	MUC5B_uc001ltb.2_Missense_Mutation_p.G5173S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5170	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTGAGCAGCGGTTTCAGCAA	0.607		NA											11	31					0	0	0	0
CARS	833	broad.mit.edu	37	11	3061081	3061081	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:3061081G>A	uc001lxh.2	-	4	361	c.287C>T	c.(286-288)ACG>ATG	p.T96M	CARS_uc001lxe.2_Missense_Mutation_p.T86M|CARS_uc001lxf.2_Missense_Mutation_p.T179M|CARS_uc001lxg.2_Missense_Mutation_p.T96M|CARS_uc010qxo.1_Missense_Mutation_p.T179M|CARS_uc010qxp.1_Missense_Mutation_p.T109M|uc001lxi.1_Intron	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	96					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	ATCAATATCCGTAATGTTCAT	0.294		NA	T	ALK	ALCL								4	42					0	0	0	0
OR51F2	119694	broad.mit.edu	37	11	4843392	4843392	+	Silent	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:4843392C>A	uc010qyn.1	+	1	777	c.777C>A	c.(775-777)ATC>ATA	p.I259I		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CATCCCACATCAGTGCTGTTT	0.493		NA											22	72					7.45e-12	8.83e-12	1	0
MRGPRX1	259249	broad.mit.edu	37	11	18955550	18955550	+	Missense_Mutation	SNP	G	G	T	rs150108666		TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:18955550G>T	uc001mpg.2	-	1	1000	c.782C>A	c.(781-783)TCC>TAC	p.S261Y		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	261	Helical; Name=7; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						GTTAAGAGCGGACAGGAAAAT	0.463		NA											33	97					1.62e-16	1.94e-16	1	0
PAMR1	25891	broad.mit.edu	37	11	35454125	35454125	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:35454125A>G	uc001mwg.2	-	11	1985	c.1942T>C	c.(1942-1944)TTC>CTC	p.F648L	PAMR1_uc001mwf.2_Missense_Mutation_p.F665L|PAMR1_uc010rew.1_Missense_Mutation_p.F537L|PAMR1_uc010rex.1_Missense_Mutation_p.F608L	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	648	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CTGGCACAGAACATGTTATCA	0.597		NA											15	42					0	0	0	0
LRP4	4038	broad.mit.edu	37	11	46911062	46911062	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:46911062G>T	uc001ndn.3	-	16	2261	c.2115C>A	c.(2113-2115)AAC>AAA	p.N705K		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	705	Extracellular (Potential).|EGF-like 3.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		AGCCTCCGTTGTTGTCCCCAC	0.592		NA									OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	118					3.1e-07	3.57e-07	1	0
EFEMP2	30008	broad.mit.edu	37	11	65638052	65638052	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:65638052A>T	uc001ofy.3	-	5	639	c.445T>A	c.(445-447)TGC>AGC	p.C149S	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.C149S	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	149	EGF-like 2; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GGGCAGGTGCACTGATAGGAG	0.622		NA											13	27					0	0	0	0
HYOU1	10525	broad.mit.edu	37	11	118925377	118925377	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:118925377G>A	uc001puu.2	-	7	700	c.507C>T	c.(505-507)ATC>ATT	p.I169I	HYOU1_uc001put.2_Silent_p.I134I|HYOU1_uc010ryu.1_Silent_p.I189I|HYOU1_uc010ryv.1_Silent_p.I58I|HYOU1_uc001pux.3_Silent_p.I169I|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Silent_p.I169I	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	169						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		CTGCATCCTTGATGGGCTGCT	0.458		NA											9	26					0	0	0	0
LPAR5	57121	broad.mit.edu	37	12	6729533	6729533	+	Silent	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:6729533C>T	uc009zer.2	-	2	1163	c.882G>A	c.(880-882)CCG>CCA	p.P294P	LPAR5_uc001qps.2_Silent_p.P294P|LPAR5_uc010sff.1_Silent_p.P294P	NM_001142961	NP_001136433	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	294	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2						AGTACACCAGCGGGTCCAGCA	0.726		NA											12	25					0	0	0	0
CLEC1A	51267	broad.mit.edu	37	12	10233841	10233841	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:10233841G>A	uc001qxb.2	-	3	470	c.386C>T	c.(385-387)GCT>GTT	p.A129V	CLEC1A_uc009zhf.2_Missense_Mutation_p.A41V|CLEC1A_uc001qxc.2_Missense_Mutation_p.A41V|CLEC1A_uc001qxd.2_Missense_Mutation_p.A86V|CLEC1A_uc010sgx.1_Intron	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	129	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						CTTACCTCCAGCTTTGTTATA	0.453		NA											13	264					0	0	0	0
PRB3	5544	broad.mit.edu	37	12	11421068	11421068	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:11421068G>A	uc001qzs.2	-	3	153	c.115C>T	c.(115-117)CGA>TGA	p.R39*	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	39	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGTGGGCGTCGTCCTTCTGGC	0.547		NA											22	190					0	0	0	0
PCBP2	5094	broad.mit.edu	37	12	53849269	53849269	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:53849269C>T	uc001sdl.3	+	4	468	c.118C>T	c.(118-120)CGC>TGC	p.R40C	PCBP2_uc001sdc.3_Missense_Mutation_p.R40C|PCBP2_uc001sdb.3_Missense_Mutation_p.R40C|PCBP2_uc001sde.3_Missense_Mutation_p.R40C|PCBP2_uc001sdi.3_Missense_Mutation_p.R40C|PCBP2_uc001sdd.3_Missense_Mutation_p.R40C|PCBP2_uc001sdf.3_Missense_Mutation_p.R40C|PCBP2_uc009zna.2_Missense_Mutation_p.R40C|PCBP2_uc010soh.1_Missense_Mutation_p.R40C|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	40	KH 1.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						TAAGAAGATGCGCGAGGAGGT	0.348		NA											4	138					0	0	0	0
NEDD1	121441	broad.mit.edu	37	12	97331091	97331091	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:97331091C>T	uc001teu.3	+	9	1376	c.1037C>T	c.(1036-1038)GCC>GTC	p.A346V	NEDD1_uc001tev.3_Missense_Mutation_p.A346V|NEDD1_uc010svc.1_Missense_Mutation_p.A257V|NEDD1_uc001tew.2_Missense_Mutation_p.A353V|NEDD1_uc001tex.2_Missense_Mutation_p.A257V	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	346					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GAAGCACCTGCCACGTCCATT	0.433		NA											104	109					0	0	0	0
SSH1	54434	broad.mit.edu	37	12	109182226	109182226	+	Missense_Mutation	SNP	C	C	A	rs148301801		TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:109182226C>A	uc001tnm.2	-	15	2775	c.2688G>T	c.(2686-2688)AAG>AAT	p.K896N	SSH1_uc001tnl.2_Missense_Mutation_p.K584N	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	896					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GAGGGGGGCTCTTCAGTGAGC	0.597		NA											26	72					3.67e-16	4.39e-16	1	0
RIMBP2	23504	broad.mit.edu	37	12	130927171	130927171	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:130927171G>A	uc001uil.2	-	8	839	c.675C>T	c.(673-675)CCC>CCT	p.P225P	RIMBP2_uc001uim.2_Silent_p.P133P|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	225	SH3 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGAAGTTGGAGGGCACCAGAC	0.597		NA											34	46					0	0	0	0
INTS6	26512	broad.mit.edu	37	13	51957877	51957877	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr13:51957877G>A	uc001vfk.2	-	8	1509	c.895C>T	c.(895-897)CCA>TCA	p.P299S	INTS6_uc001vfi.2_5'UTR|INTS6_uc001vfj.2_Missense_Mutation_p.P286S|INTS6_uc001vfl.2_Missense_Mutation_p.P121S	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	299					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		GTACGAGGTGGCTAAAGGGGA	0.353		NA											10	91					0	0	0	0
ATP7B	540	broad.mit.edu	37	13	52548430	52548430	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr13:52548430A>G	uc001vfw.2	-	2	1083	c.926T>C	c.(925-927)GTG>GCG	p.V309A	ATP7B_uc010adv.2_Missense_Mutation_p.V309A|ATP7B_uc001vfx.2_Missense_Mutation_p.V309A|ATP7B_uc001vfy.2_Intron|ATP7B_uc010tgt.1_Missense_Mutation_p.V309A|ATP7B_uc010tgu.1_Missense_Mutation_p.V309A|ATP7B_uc010tgv.1_Missense_Mutation_p.V309A|ATP7B_uc010tgw.1_Missense_Mutation_p.V277A	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	309	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CTGCAGAGCCACTGGGCTGGT	0.488		NA							Wilson_disease				23	109					0	0	0	0
OR11H4	390442	broad.mit.edu	37	14	20711912	20711912	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr14:20711912G>A	uc010tld.1	+	1	962	c.962G>A	c.(961-963)CGT>CAT	p.R321H		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	321	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ATGAGAATTCGTCAAAATTCG	0.393		NA											39	80					0	0	0	0
PLEK2	26499	broad.mit.edu	37	14	67864498	67864498	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr14:67864498G>A	uc001xjh.1	-	2	140	c.88C>T	c.(88-90)CAG>TAG	p.Q30*		NM_016445	NP_057529	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	30	PH 1.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				ovary(1)|pancreas(1)	2				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		AGCGTGTTCTGCCGAAGGATG	0.602		NA											9	24					0	0	0	0
TYRO3	7301	broad.mit.edu	37	15	41859568	41859568	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr15:41859568C>A	uc001zof.1	+	7	1018	c.794C>A	c.(793-795)GCC>GAC	p.A265D		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	265	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.A265G(1)		ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTGACACAGGCCCCAGGAGGC	0.557		NA											6	121					0.00116845	0.00129583	1	0
SGK269	79834	broad.mit.edu	37	15	77407481	77407481	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr15:77407481C>G	uc002bcm.2	-	6	4566	c.4258G>C	c.(4258-4260)GAG>CAG	p.E1420Q		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1420	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCTTCAGTCTCTTCCATGTCA	0.498		NA											6	160					0	0	0	0
TTC23	64927	broad.mit.edu	37	15	99762036	99762036	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr15:99762036C>T	uc002bur.2	-	5	745	c.214G>A	c.(214-216)GTA>ATA	p.V72I	TTC23_uc002bus.2_Missense_Mutation_p.V72I|TTC23_uc002but.2_Missense_Mutation_p.V72I|TTC23_uc002buu.2_Missense_Mutation_p.V72I|TTC23_uc002buv.2_Missense_Mutation_p.V72I|TTC23_uc002bux.2_Missense_Mutation_p.V72I|TTC23_uc002buw.2_Missense_Mutation_p.V72I|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Missense_Mutation_p.V72I|TTC23_uc010bor.2_Missense_Mutation_p.V72I|TTC23_uc002buz.2_Missense_Mutation_p.V72I	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	72	TPR 1.						binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			GTCAGTGCTACGCAACGCACA	0.448		NA											14	48					0	0	0	0
ZG16B	124220	broad.mit.edu	37	16	2880259	2880259	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:2880259A>C	uc002cru.2	+	1	87	c.11A>C	c.(10-12)CAG>CCG	p.Q4P		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	4						extracellular region	sugar binding			ovary(1)	1						ATGGGGGCCCAGGGGGCCCAG	0.687		NA											3	23					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565101	20565101	+	Silent	SNP	A	A	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:20565101A>C	uc002dhj.3	-	6	948	c.738T>G	c.(736-738)GCT>GCG	p.A246A	ACSM2B_uc002dhk.3_Silent_p.A246A|ACSM2B_uc010bwf.1_Silent_p.A246A	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	246					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CAGCTTACCCAGCATCCATCT	0.512		NA											27	104					0	0	0	0
EARS2	124454	broad.mit.edu	37	16	23541092	23541092	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:23541092G>A	uc002dlt.3	-	6	1226	c.1194C>T	c.(1192-1194)TAC>TAT	p.Y398Y	EARS2_uc002dlr.3_RNA|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Silent_p.Y398Y	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	398					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	TCCTCTCCACGTAGACTGGGT	0.592		NA											27	181					0	0	0	0
CYLD	1540	broad.mit.edu	37	16	50811826	50811826	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:50811826C>A	uc002egp.1	+	8	1527	c.1112C>A	c.(1111-1113)TCA>TAA	p.S371*	CYLD_uc002egn.1_Nonsense_Mutation_p.S368*|CYLD_uc002ego.2_Nonsense_Mutation_p.S368*|CYLD_uc010cbs.1_Nonsense_Mutation_p.S368*|CYLD_uc002egq.1_Nonsense_Mutation_p.S368*|CYLD_uc002egr.1_Nonsense_Mutation_p.S368*|CYLD_uc002egs.1_Nonsense_Mutation_p.S368*	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	371	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.S371*(1)		skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				CAATCCAAATCAAAAAATACA	0.313		NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				7	126					8.13e-05	9.12e-05	1	0
GPR56	9289	broad.mit.edu	37	16	57689388	57689388	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:57689388G>A	uc002emb.2	+	7	1138	c.846G>A	c.(844-846)GGG>GGA	p.G282G	GPR56_uc002elz.1_Silent_p.G112G|GPR56_uc002ema.1_Silent_p.G107G|GPR56_uc002emc.2_Silent_p.G282G|GPR56_uc002emf.2_Silent_p.G282G|GPR56_uc010vhs.1_Silent_p.G282G|GPR56_uc002emd.2_Silent_p.G282G|GPR56_uc002eme.2_Silent_p.G282G|GPR56_uc010vht.1_Silent_p.G287G|GPR56_uc002emg.3_Silent_p.G282G|GPR56_uc010vhu.1_Silent_p.G107G	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	282	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						GCCGGAGCGGGGAGGCTGAGA	0.587		NA											7	40					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65032522	65032522	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:65032522G>T	uc002eoi.2	-	4	900	c.466C>A	c.(466-468)CCT>ACT	p.P156T	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.P156T|CDH11_uc010vin.1_Missense_Mutation_p.P30T|CDH11_uc010vio.1_Missense_Mutation_p.P156T	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	156	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTCCGGAGGGTTGTCATTA	0.587		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			9	95					7.48e-07	8.56e-07	1	0
TMCO7	79613	broad.mit.edu	37	16	68912102	68912102	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:68912102T>C	uc002ewi.3	+	6	1225	c.1213T>C	c.(1213-1215)TCA>CCA	p.S405P		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	405						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TATAACTTTGTCAAGAGAACG	0.403		NA											3	45					0	0	0	0
PIK3R5	23533	broad.mit.edu	37	17	8812440	8812440	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:8812440G>A	uc002glt.2	-	3	222	c.155C>T	c.(154-156)CCG>CTG	p.P52L	PIK3R5_uc010vuz.1_Missense_Mutation_p.P52L|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.P52L|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	52	Heterodimerization (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAAGTGGCCCGGGTCCCTGCT	0.592		NA											3	30					0	0	0	0
KRT38	8687	broad.mit.edu	37	17	39593678	39593678	+	Missense_Mutation	SNP	C	C	T	rs148086126	byFrequency	TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:39593678C>T	uc002hwq.1	-	7	1780	c.1357G>A	c.(1357-1359)GGA>AGA	p.G453R		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	453	Tail.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AATCGGCTTCCGGTGGTGCTG	0.592		NA											8	9					0	0	0	0
BRIP1	83990	broad.mit.edu	37	17	59876570	59876570	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:59876570T>C	uc002izk.1	-	9	1372	c.1231A>G	c.(1231-1233)ACA>GCA	p.T411A		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	411	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						TGAACTTCTGTTACACTGTAA	0.398		NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				37	135					0	0	0	0
SLC25A19	60386	broad.mit.edu	37	17	73282528	73282528	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:73282528G>A	uc002jns.3	-	2	1055	c.145C>T	c.(145-147)CGC>TGC	p.R49C	SLC25A19_uc010dge.2_Missense_Mutation_p.R49C|SLC25A19_uc002jnv.3_Missense_Mutation_p.R49C|SLC25A19_uc002jnu.3_Missense_Mutation_p.R49C|SLC25A19_uc002jnw.3_Missense_Mutation_p.R49C|SLC25A19_uc002jnt.3_Missense_Mutation_p.R49C	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	49	Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			CGAGACAGGCGCTCATGCTGA	0.532		NA											4	118					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7080343	7080343	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr18:7080343G>A	uc002knm.2	-	2	269	c.175C>T	c.(175-177)CGG>TGG	p.R59W	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	59	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGACGGGCCGACCTGGCACA	0.547		NA											72	110					0	0	0	0
MC2R	4158	broad.mit.edu	37	18	13885277	13885277	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr18:13885277T>A	uc002ksp.1	-	2	418	c.241A>T	c.(241-243)AAT>TAT	p.N81Y		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	81	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	ATCAGGATATTTTCCAAGATC	0.448		NA											108	43					0	0	0	0
ZNF407	55628	broad.mit.edu	37	18	72343784	72343784	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr18:72343784G>A	uc002llw.2	+	1	866	c.809G>A	c.(808-810)CGT>CAT	p.R270H	ZNF407_uc010xfc.1_Missense_Mutation_p.R270H|ZNF407_uc010dqu.1_Missense_Mutation_p.R270H|ZNF407_uc002llu.2_Missense_Mutation_p.R269H	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ACACATCTCCGTCGTCAGAAT	0.403		NA											11	195					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22156525	22156525	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:22156525G>A	uc002nqp.2	-	4	1460	c.1311C>T	c.(1309-1311)TCC>TCT	p.S437S	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGGTTTGAGGACCAGTTGA	0.378		NA											11	169					0	0	0	0
BLVRB	645	broad.mit.edu	37	19	40971542	40971542	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:40971542G>A	uc002onw.2	-	1	184	c.54C>T	c.(52-54)ACC>ACT	p.T18T	SPTBN4_uc002onx.2_5'Flank|SPTBN4_uc002ony.2_5'Flank|SPTBN4_uc002onz.2_5'Flank|BLVRB_uc010egw.1_RNA	NM_000713	NP_000704	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase	18					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	GCGCCAGGGTGGTGAGCCCGG	0.687		NA											11	26					0	0	0	0
ZNF610	162963	broad.mit.edu	37	19	52857030	52857030	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:52857030G>A	uc002pyx.3	+	4	565	c.159G>A	c.(157-159)ATG>ATA	p.M53I	ZNF610_uc002pyy.3_Missense_Mutation_p.M53I|ZNF610_uc002pyz.3_Missense_Mutation_p.M53I|ZNF610_uc002pza.2_Missense_Mutation_p.M53I	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	53	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGGACGTGATGTTGGAGAACT	0.512		NA											26	203					0	0	0	0
ZNF71	58491	broad.mit.edu	37	19	57132929	57132929	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:57132929C>T	uc002qnm.3	+	3	512	c.274C>T	c.(274-276)CGG>TGG	p.R92W		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	92						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGTCCCACCACGGCTGGACGA	0.582		NA											5	82					0	0	0	0
ZNF835	90485	broad.mit.edu	37	19	57175917	57175917	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:57175917G>A	uc010ygo.1	-	2	716	c.716C>T	c.(715-717)ACG>ATG	p.T239M	ZNF835_uc010ygn.1_Missense_Mutation_p.T217M	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CCGCTCGCCCGTGTGCACGCG	0.711		NA											7	18					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141806556	141806556	+	Silent	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:141806556A>G	uc002tvj.1	-	11	2760	c.1788T>C	c.(1786-1788)GAT>GAC	p.D596D	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	596	Extracellular (Potential).|LDL-receptor class B 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCACTTACCATCTTTCAGGA	0.418		NA								TSP Lung(27;0.18)			45	148					0	0	0	0
MBD5	55777	broad.mit.edu	37	2	149226535	149226535	+	Silent	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:149226535A>G	uc002twm.3	+	9	2011	c.1023A>G	c.(1021-1023)CCA>CCG	p.P341P	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.P341P|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	341	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CCCCTCCTCCACCTTCTTGTG	0.428		NA											13	58					0	0	0	0
ITGB6	3694	broad.mit.edu	37	2	161029176	161029176	+	Silent	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:161029176A>G	uc002ubh.2	-	6	841	c.825T>C	c.(823-825)CAT>CAC	p.H275H	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Silent_p.H275H|ITGB6_uc010zcq.1_Silent_p.H233H|ITGB6_uc010fov.1_Silent_p.H275H	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	275	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						CCATTCCAAAATGAGAATCAG	0.448		NA											10	213					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238269816	238269816	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:238269816C>A	uc002vwl.2	-	16	6443	c.6158G>T	c.(6157-6159)GGT>GTT	p.G2053V	COL6A3_uc002vwo.2_Missense_Mutation_p.G1847V|COL6A3_uc010znj.1_Missense_Mutation_p.G1446V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2053	Triple-helical region.|Collagen-like 1.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCCAGGAATACCCTGAAACAA	0.478		NA											4	72					2.56e-06	2.92e-06	1	0
ITCH	83737	broad.mit.edu	37	20	33033193	33033193	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr20:33033193A>G	uc010geu.1	+	12	1382	c.1190A>G	c.(1189-1191)TAT>TGT	p.Y397C	ITCH_uc002xak.2_Missense_Mutation_p.Y356C|ITCH_uc010zuj.1_Missense_Mutation_p.Y246C	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	397	Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GTCCGGAACTATGAACAATGG	0.458		NA											85	137					0	0	0	0
COL6A2	1292	broad.mit.edu	37	21	47545457	47545457	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr21:47545457C>A	uc002zia.1	+	25	1977	c.1895C>A	c.(1894-1896)ACA>AAA	p.T632K	COL6A2_uc002zhy.1_Missense_Mutation_p.T632K|COL6A2_uc002zhz.1_Missense_Mutation_p.T632K|COL6A2_uc002zib.1_Missense_Mutation_p.T38K|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	632	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACCAACTTCACACTGGAGAAG	0.617		NA											3	42					0.004672	0.00512357	1	0
EP300	2033	broad.mit.edu	37	22	41553402	41553402	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr22:41553402G>A	uc003azl.3	+	18	3886	c.3491G>A	c.(3490-3492)TGT>TAT	p.C1164Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1164					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGATACTGTTGTGGCAGAAAG	0.393		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				113	70					0	0	0	0
KLF15	28999	broad.mit.edu	37	3	126070938	126070938	+	Silent	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr3:126070938G>C	uc011bkk.1	-	2	1010	c.828C>G	c.(826-828)TCC>TCG	p.S276S		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	276						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		GCACAAACTTGGAGGGCAGGT	0.627		NA											2	9					0	0	0	0
DNAJC13	23317	broad.mit.edu	37	3	132186135	132186135	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr3:132186135G>T	uc003eor.2	+	20	2251	c.2186G>T	c.(2185-2187)AGG>ATG	p.R729M	DNAJC13_uc010htq.1_Missense_Mutation_p.R729M	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	729							heat shock protein binding			ovary(1)|breast(1)	2						TGGAGGGATAGGATGGGCATT	0.398		NA											12	154					6.4e-05	7.24e-05	1	0
FXR1	8087	broad.mit.edu	37	3	180688116	180688116	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr3:180688116G>A	uc003fkq.2	+	15	1595	c.1573G>A	c.(1573-1575)GAT>AAT	p.D525N	FXR1_uc003fkp.2_Missense_Mutation_p.D440N|FXR1_uc003fkr.2_Missense_Mutation_p.D525N|FXR1_uc011bqj.1_Missense_Mutation_p.D439N|FXR1_uc003fks.2_Missense_Mutation_p.D468N|FXR1_uc011bqk.1_Missense_Mutation_p.D476N|FXR1_uc011bql.1_Missense_Mutation_p.D512N	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	525					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GACTGAATCTGATACAGCTTC	0.353		NA											12	206					0	0	0	0
LYAR	55646	broad.mit.edu	37	4	4281210	4281210	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr4:4281210G>C	uc011bvy.1	-	6	536	c.393C>G	c.(391-393)GAC>GAG	p.D131E	LYAR_uc011bvx.1_Missense_Mutation_p.D14E|LYAR_uc003ght.2_Missense_Mutation_p.D131E	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	131						nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCCACACCTGGTCCAGAATGG	0.338		NA											39	63					0	0	0	0
CCKAR	886	broad.mit.edu	37	4	26491091	26491091	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr4:26491091A>G	uc003gse.1	-	2	281	c.128T>C	c.(127-129)GTG>GCG	p.V43A		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	43	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GAGAATCTGCACCGCTGGCTG	0.552		NA											6	58					0	0	0	0
UBA6	55236	broad.mit.edu	37	4	68490887	68490887	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr4:68490887A>G	uc003hdg.3	-	29	2589	c.2537T>C	c.(2536-2538)GTG>GCG	p.V846A		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	846					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						AAATGAAAGCACTGCCATCTG	0.368		NA											4	150					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13701532	13701532	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:13701532G>C	uc003jfd.2	-	77	13394	c.13352C>G	c.(13351-13353)TCT>TGT	p.S4451C	DNAH5_uc003jfc.2_Missense_Mutation_p.S619C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4451				S -> F (in Ref. 5; BAB15543).	microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAGTGTACTAGAAATCCAAGA	0.373		NA							Kartagener_syndrome				5	143					0	0	0	0
PARP8	79668	broad.mit.edu	37	5	50091099	50091099	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:50091099C>T	uc003jon.3	+	13	1458	c.1276C>T	c.(1276-1278)CAC>TAC	p.H426Y	PARP8_uc011cpz.1_Missense_Mutation_p.H318Y|PARP8_uc003joo.2_Missense_Mutation_p.H426Y|PARP8_uc003jop.2_Missense_Mutation_p.H426Y	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	426						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ACTGAAAAATCACAAATTGCT	0.448		NA											24	177					0	0	0	0
FAM169A	26049	broad.mit.edu	37	5	74091962	74091962	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:74091962C>T	uc003kdm.2	-	11	1196	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	FAM169A_uc010izm.2_Missense_Mutation_p.E325K|FAM169A_uc003kdl.2_Missense_Mutation_p.E203K	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	385	Asp/Glu-rich.										0						TCAGGTTCTTCTTCCAGGAAT	0.423		NA											13	207					0	0	0	0
DIAPH1	1729	broad.mit.edu	37	5	140960400	140960400	+	Silent	SNP	G	G	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:140960400G>C	uc003llb.3	-	8	876	c.735C>G	c.(733-735)GTC>GTG	p.V245V	DIAPH1_uc003llc.3_Silent_p.V236V	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	245	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGCTCTGACCAGCAGTA	0.463		NA											8	116					0	0	0	0
PCDH12	51294	broad.mit.edu	37	5	141336689	141336689	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:141336689G>A	uc003llx.2	-	1	1939	c.728C>T	c.(727-729)GCG>GTG	p.A243V		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	243	Extracellular (Potential).|Cadherin 2.				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGCAAACGCAGGGCTATT	0.512		NA											24	93					0	0	0	0
TTC1	7265	broad.mit.edu	37	5	159476610	159476610	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:159476610G>A	uc003lxu.2	+	6	681	c.631G>A	c.(631-633)GAC>AAC	p.D211N		NM_003314	NP_003305	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	211	TPR 3.				protein folding		unfolded protein binding			skin(1)	1	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		AGCCCTGGAAGACTATAAATC	0.333		NA											5	52					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160042962	160042962	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:160042962C>T	uc003lym.1	-	17	3383	c.2536G>A	c.(2536-2538)GAA>AAA	p.E846K	ATP10B_uc010jit.1_Missense_Mutation_p.E163K|ATP10B_uc003lyn.2_Missense_Mutation_p.E404K	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	846	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGTCCTCTTCGCTTACAACC	0.527		NA											17	55					0	0	0	0
ABCC10	89845	broad.mit.edu	37	6	43400422	43400422	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:43400422G>A	uc003ouy.1	+	3	919	c.704G>A	c.(703-705)CGT>CAT	p.R235H	ABCC10_uc003ouz.1_Missense_Mutation_p.R192H	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	235						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TTGCTGGCCCGTGGGGCCTGT	0.637		NA											11	66					0	0	0	0
RIMS1	22999	broad.mit.edu	37	6	73023290	73023290	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:73023290G>A	uc003pga.2	+	28	4122	c.4045G>A	c.(4045-4047)GCC>ACC	p.A1349T	RIMS1_uc011dyb.1_Missense_Mutation_p.A746T|RIMS1_uc003pgc.2_Missense_Mutation_p.A798T|RIMS1_uc010kaq.2_Missense_Mutation_p.A669T|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_Missense_Mutation_p.A358T|RIMS1_uc003pgg.2_Intron|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Missense_Mutation_p.A415T|RIMS1_uc003pge.2_Missense_Mutation_p.A389T|RIMS1_uc011dye.1_Missense_Mutation_p.A155T|RIMS1_uc011dyf.1_Intron	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1349	Ser-rich.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGATGTTTCCGCCATTTCCCG	0.448		NA											11	36					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152451872	152451872	+	Silent	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:152451872G>A	uc010kiw.2	-	145	26738	c.26136C>T	c.(26134-26136)GTC>GTT	p.V8712V	SYNE1_uc010kiv.2_Silent_p.V3236V|SYNE1_uc003qos.3_Silent_p.V3236V|SYNE1_uc003qot.3_Silent_p.V8664V|SYNE1_uc003qou.3_Silent_p.V8712V|SYNE1_uc003qop.3_Silent_p.V897V|SYNE1_uc011eez.1_Intron|SYNE1_uc003qoq.3_Intron|SYNE1_uc003qor.3_Intron	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8712	Ser-rich.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTGGACTGCTGACAGAGGGTC	0.468		NA								HNSCC(10;0.0054)			8	34					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152728244	152728244	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:152728244C>G	uc010kiw.2	-	45	7230	c.6628G>C	c.(6628-6630)GAG>CAG	p.E2210Q	SYNE1_uc003qot.3_Missense_Mutation_p.E2217Q|SYNE1_uc003qou.3_Missense_Mutation_p.E2210Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E2193Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2210	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACCATCCCTCAATCTCATCT	0.428		NA								HNSCC(10;0.0054)			8	127					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152746543	152746543	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:152746543C>G	uc010kiw.2	-	39	5842	c.5240G>C	c.(5239-5241)AGA>ACA	p.R1747T	SYNE1_uc003qot.3_Missense_Mutation_p.R1754T|SYNE1_uc003qou.3_Missense_Mutation_p.R1747T|SYNE1_uc010kjb.1_Missense_Mutation_p.R1730T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1747	Spectrin 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTAAATCTCTCCATCTCTC	0.318		NA								HNSCC(10;0.0054)			5	163					0	0	0	0
C6orf118	168090	broad.mit.edu	37	6	165715113	165715113	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:165715113T>C	uc003qum.3	-	2	734	c.698A>G	c.(697-699)AAG>AGG	p.K233R	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	233											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		GAAGTCATTCTTCAGGAGATC	0.607		NA											3	101					0	0	0	0
ASZ1	136991	broad.mit.edu	37	7	117007450	117007450	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr7:117007450C>A	uc003vjb.2	-	12	1294	c.1231G>T	c.(1231-1233)GAT>TAT	p.D411Y	ASZ1_uc011kno.1_Missense_Mutation_p.D402Y|ASZ1_uc011knp.1_Missense_Mutation_p.D203Y	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	411					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCACTCAAATCTTCAACATTA	0.303		NA											4	46					0.00116845	0.00129583	1	0
RIMS2	9699	broad.mit.edu	37	8	104897724	104897724	+	Silent	SNP	A	A	G			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr8:104897724A>G	uc003yls.2	+	2	472	c.231A>G	c.(229-231)AGA>AGG	p.R77R	RIMS2_uc003ylp.2_Silent_p.R299R|RIMS2_uc003ylw.2_Silent_p.R107R|RIMS2_uc003ylq.2_Silent_p.R107R|RIMS2_uc003ylr.2_Silent_p.R107R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	330					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCAACAGGAGAAGTCATAGGC	0.413		NA								HNSCC(12;0.0054)			4	151					0	0	0	0
ASAP1	50807	broad.mit.edu	37	8	131127917	131127917	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr8:131127917C>T	uc003yta.1	-	22	2157	c.2129G>A	c.(2128-2130)CGA>CAA	p.R710Q	ASAP1_uc003ysz.1_Missense_Mutation_p.R521Q|ASAP1_uc011liw.1_Missense_Mutation_p.R703Q	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	710					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CTCCTCCTGTCGAAGATTCCA	0.413		NA											32	478					0	0	0	0
TAF1L	138474	broad.mit.edu	37	9	32635464	32635464	+	Silent	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr9:32635464C>T	uc003zrg.1	-	1	204	c.114G>A	c.(112-114)GCG>GCA	p.A38A	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	38					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AAAGGATACCCGCTAAAGTAA	0.567		NA											7	153					0	0	0	0
CTSL1	1514	broad.mit.edu	37	9	90343233	90343233	+	Silent	SNP	C	C	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr9:90343233C>T	uc004aph.2	+	4	668	c.318C>T	c.(316-318)TTC>TTT	p.F106F	CTSL1_uc004api.2_Silent_p.F106F|CTSL1_uc004apj.2_Silent_p.F51F|CTSL1_uc010mqh.2_Intron|CTSL1_uc004apk.2_Silent_p.F106F|CTSL1_uc004apl.2_Silent_p.F106F	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	106					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GGAAAGTGTTCCAGGAACCTC	0.458		NA											15	114					0	0	0	0
OR1L4	254973	broad.mit.edu	37	9	125486377	125486377	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr9:125486377C>A	uc004bmu.1	+	1	109	c.109C>A	c.(109-111)CTA>ATA	p.L37I		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATCATGTACCTACTCACTGC	0.498		NA											15	246					2.62e-11	3.09e-11	1	0
OR13H1	347468	broad.mit.edu	37	X	130678201	130678201	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chrX:130678201G>A	uc011muw.1	+	1	154	c.154G>A	c.(154-156)GAC>AAC	p.D52N	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TATTCACTTTGACCCCAACCT	0.413		NA											61	177					0	0	0	0
IL9R	3581	broad.mit.edu	37	X	155232635	155232635	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chrX:155232635C>A	uc004fnv.1	+	2	272	c.93C>A	c.(91-93)TGC>TGA	p.C31*	IL9R_uc010nvn.2_Nonsense_Mutation_p.C10*|IL9R_uc004fnu.1_Nonsense_Mutation_p.C78*	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	31					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCTGCATCTGCATCTGCACCT	0.597		NA											51	134					6.15e-18	7.4e-18	1	0
ZHX3	23051	broad.mit.edu	37	20	39831282	39831285	+	Frame_Shift_Del	DEL	GTTT	GTTT	-			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr20:39831282_39831285delGTTT	uc002xjs.1	-	3	2650_2653	c.2272_2275delAAAC	c.(2272-2277)AAACTGfs	p.K758fs	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xjt.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xju.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xjv.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xjw.1_Frame_Shift_Del_p.K758fs|ZHX3_uc010ggg.1_Frame_Shift_Del_p.K758fs	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	758_759					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				TGCTCTGCCAGTTTGTTTGACTCA	0.544		NA											24	125	---	---	---	---	NA	NA	NA	NA
C5orf25	375484	broad.mit.edu	37	5	175717758	175717759	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:175717758_175717759delCT	uc003mds.3	+	4	1581_1582	c.1174_1175delCT	c.(1174-1176)CTCfs	p.L392fs	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Frame_Shift_Del_p.L411fs			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	392											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		AGTTCCTTGGCTCTCTGTCATG	0.515		NA											15	110	---	---	---	---	NA	NA	NA	NA
STAU2	27067	broad.mit.edu	37	8	74507470	74507471	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr8:74507470_74507471insT	uc003xzm.2	-	11	1327_1328	c.1091_1092insA	c.(1090-1092)AATfs	p.N364fs	STAU2_uc011lfg.1_Frame_Shift_Ins_p.N192fs|STAU2_uc003xzn.2_Frame_Shift_Ins_p.N332fs|STAU2_uc011lfh.1_Frame_Shift_Ins_p.N260fs|STAU2_uc003xzo.2_Frame_Shift_Ins_p.N364fs|STAU2_uc003xzp.2_Frame_Shift_Ins_p.N332fs|STAU2_uc011lfi.1_Frame_Shift_Ins_p.N326fs|STAU2_uc003xzq.2_Frame_Shift_Ins_p.N144fs|STAU2_uc010lzk.2_Frame_Shift_Ins_p.N332fs|STAU2_uc010lzl.1_Frame_Shift_Ins_p.N192fs	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	364	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			CTTCTGCAGCATTTTTTTTGGC	0.327		NA											7	254	---	---	---	---	NA	NA	NA	NA