Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
HTR1D	3352	broad.mit.edu	37	1	23520575	23520575	+	Silent	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:23520575G>A	uc001bgn.2	-	1	648	c.138C>T	c.(136-138)TCC>TCT	p.S46S		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	46	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GTGTGATGACGGAAAGGACCA	0.572		NA											91	101					0	0	0	0
S100PBP	64766	broad.mit.edu	37	1	33295639	33295639	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:33295639A>C	uc001bvz.2	+	5	1272	c.995A>C	c.(994-996)CAT>CCT	p.H332P	S100PBP_uc001bwa.1_Missense_Mutation_p.H331P|S100PBP_uc001bwb.1_Missense_Mutation_p.H332P|S100PBP_uc001bwc.2_Missense_Mutation_p.H332P|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	332						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GTCATTGCTCATATAGAAGAC	0.403		NA											29	140					0	0	0	0
WLS	79971	broad.mit.edu	37	1	68613869	68613869	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:68613869T>G	uc001def.1	-	8	1355	c.1084A>C	c.(1084-1086)ACG>CCG	p.T362P	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.T360P|WLS_uc001deg.1_Missense_Mutation_p.T271P|WLS_uc009wbf.1_Missense_Mutation_p.T317P	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	362	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						AAGGGATTCGTGAGTTGTACC	0.443		NA											21	183					0	0	0	0
CTH	1491	broad.mit.edu	37	1	70881666	70881666	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:70881666C>G	uc001dfd.2	+	2	340	c.196C>G	c.(196-198)CCC>GCC	p.P66A	CTH_uc009wbl.1_RNA|CTH_uc001dfe.2_Missense_Mutation_p.P66A|CTH_uc010oqq.1_Missense_Mutation_p.P66A	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	66					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TTCTGGAAATCCCACTAGGAA	0.358		NA											15	95					0	0	0	0
CCBL2	56267	broad.mit.edu	37	1	89427140	89427140	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:89427140G>C	uc001dmp.2	-	7	967	c.590C>G	c.(589-591)CCT>CGT	p.P197R	CCBL2_uc001dmq.2_Missense_Mutation_p.P163R|CCBL2_uc001dmr.2_Missense_Mutation_p.P33R	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	197					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAGTTCTTGAGGATCTAATGT	0.323		NA											40	209					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152281203	152281203	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:152281203G>C	uc001ezu.1	-	3	6195	c.6159C>G	c.(6157-6159)GAC>GAG	p.D2053E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2053	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTGTCTGAGTCTTCTGAAT	0.562		NA							Ichthyosis				17	798					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152281224	152281224	+	Silent	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:152281224G>A	uc001ezu.1	-	3	6174	c.6138C>T	c.(6136-6138)GAC>GAT	p.D2046D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2046	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCCTCACTGTCACTGGCCT	0.562		NA							Ichthyosis				21	833					0	0	0	0
NAV1	89796	broad.mit.edu	37	1	201751710	201751710	+	Silent	SNP	A	A	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:201751710A>T	uc001gwu.2	+	6	2417	c.2070A>T	c.(2068-2070)GGA>GGT	p.G690G	NAV1_uc001gwv.1_Silent_p.G198G|NAV1_uc001gww.1_Silent_p.G299G|NAV1_uc001gwx.2_Silent_p.G299G|NAV1_uc001gwy.1_Silent_p.G71G	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	690					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						GGCGGGGTGGACCTCGCCCTG	0.627		NA											47	44					0	0	0	0
SVIL	6840	broad.mit.edu	37	10	29821795	29821795	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:29821795G>C	uc001iut.1	-	8	2254	c.1501C>G	c.(1501-1503)CAA>GAA	p.Q501E	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.Q501E	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	501					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGCGGAGCTTGAGGGGGTTGT	0.532		NA											29	121					0	0	0	0
NRG3	10718	broad.mit.edu	37	10	83635638	83635638	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:83635638C>A	uc001kco.2	+	1	569	c.542C>A	c.(541-543)TCC>TAC	p.S181Y	NRG3_uc010qlz.1_Missense_Mutation_p.S181Y|NRG3_uc001kcp.2_5'Flank|NRG3_uc001kcq.2_5'Flank	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	181	Ser/Thr-rich.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AGCCCGCGCTCCACCACAGCA	0.721		NA											10	34					3.86e-05	4.31e-05	1	0
MYOF	26509	broad.mit.edu	37	10	95111312	95111312	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:95111312A>T	uc001kin.2	-	34	3803	c.3680T>A	c.(3679-3681)TTA>TAA	p.L1227*	MYOF_uc001kio.2_Nonsense_Mutation_p.L1214*|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1227	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GCTTCGTCCTAAAAATTCATC	0.413		NA											41	148					0	0	0	0
MYOF	26509	broad.mit.edu	37	10	95111315	95111315	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:95111315A>T	uc001kin.2	-	34	3800	c.3677T>A	c.(3676-3678)TTT>TAT	p.F1226Y	MYOF_uc001kio.2_Missense_Mutation_p.F1213Y|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1226	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TCGTCCTAAAAATTCATCTTT	0.413		NA											40	152					0	0	0	0
COX15	1355	broad.mit.edu	37	10	101480789	101480789	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:101480789A>G	uc001kqb.3	-	6	1404	c.787T>C	c.(787-789)TTT>CTT	p.F263L	COX15_uc001kqc.3_Missense_Mutation_p.F263L|COX15_uc010qpj.1_Missense_Mutation_p.F84L	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	263					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		CCATGAGCAAATCGTCTCAAC	0.453		NA											9	41					0	0	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605950	116605950	+	Missense_Mutation	SNP	C	C	T	rs17853717		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:116605950C>T	uc001lcb.2	+	10	1557	c.1222C>T	c.(1222-1224)CTC>TTC	p.L408F	FAM160B1_uc001lcc.2_Missense_Mutation_p.L408F	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	408										lung(1)	1						GATGGGTATTCTCACATCCAC	0.433		NA											7	420					0	0	0	0
ATRNL1	26033	broad.mit.edu	37	10	117061476	117061476	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:117061476G>A	uc001lcg.2	+	17	3127	c.2741G>A	c.(2740-2742)CGA>CAA	p.R914Q	ATRNL1_uc010qsm.1_Missense_Mutation_p.R89Q|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	914	PSI 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTACGAAACGATGTGTTGAC	0.453		NA											29	163					0	0	0	0
ADAM8	101	broad.mit.edu	37	10	135083954	135083954	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:135083954G>C	uc010qva.1	-	15	1629	c.1578C>G	c.(1576-1578)ATC>ATG	p.I526M	ADAM8_uc010quz.1_Missense_Mutation_p.I565M|ADAM8_uc009ybi.2_Missense_Mutation_p.I565M			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	526					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		CCACGATGCAGATGGCACGCC	0.652		NA											19	65					0	0	0	0
EPS8L2	64787	broad.mit.edu	37	11	720157	720157	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:720157C>G	uc001lqt.2	+	5	508	c.261C>G	c.(259-261)ATC>ATG	p.I87M	EPS8L2_uc010qwj.1_Missense_Mutation_p.I87M|EPS8L2_uc001lqu.2_Missense_Mutation_p.I87M|EPS8L2_uc010qwk.1_Missense_Mutation_p.I87M|EPS8L2_uc001lqv.2_Missense_Mutation_p.I42M|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	87	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGAGAAGATCTGGACCCAGG	0.627		NA											9	38					0	0	0	0
RHOG	391	broad.mit.edu	37	11	3848803	3848803	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:3848803A>C	uc001lyu.2	-	2	724	c.566T>G	c.(565-567)ATC>AGC	p.I189S		NM_001665	NP_001656	P84095	RHOG_HUMAN	ras homolog gene family, member G precursor	189					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		TCACAAGAGGATGCAGGACCG	0.627		NA											7	30					0	0	0	0
FAM111B	374393	broad.mit.edu	37	11	58892771	58892771	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:58892771C>G	uc001nnl.2	+	4	1444	c.1201C>G	c.(1201-1203)CAG>GAG	p.Q401E	FAM111B_uc001nnm.2_Missense_Mutation_p.Q371E|FAM111B_uc010rko.1_Missense_Mutation_p.Q371E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	401							catalytic activity			ovary(2)	2						CATAATGCATCAGTATCCGAA	0.378		NA											48	113					0	0	0	0
DAGLA	747	broad.mit.edu	37	11	61503242	61503242	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:61503242A>T	uc001nsa.2	+	12	1355	c.1244A>T	c.(1243-1245)GAG>GTG	p.E415V		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	415	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GGTGATGCTGAGCGCCTCCCC	0.672		NA											6	13					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92531604	92531605	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:92531604_92531605GC>AA	uc001pdj.3	+	9	5442_5443	c.5425_5426GC>AA	c.(5425-5427)GCT>AAT	p.A1809N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1809	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAACCGGAATGCTCTGCTTGTG	0.485		NA								TCGA Ovarian(4;0.039)			5	20					0	0	0	0
A2M	2	broad.mit.edu	37	12	9222346	9222346	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:9222346C>T	uc001qvk.1	-	33	4371	c.4258G>A	c.(4258-4260)GAT>AAT	p.D1420N	A2M_uc001qvj.1_Missense_Mutation_p.D462N|A2M_uc009zgk.1_Missense_Mutation_p.D1270N	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1420					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CTTACCTTATCAAGGTAAATC	0.353		NA											40	160					0	0	0	0
ADCY6	112	broad.mit.edu	37	12	49176910	49176910	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:49176910G>A	uc001rsh.3	-	1	968	c.308C>T	c.(307-309)ACG>ATG	p.T103M	ADCY6_uc001rsj.3_Missense_Mutation_p.T103M|ADCY6_uc001rsi.3_Missense_Mutation_p.T103M	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	103	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CACCTCAGCCGTCCCGCCCGC	0.697		NA											16	59					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49434105	49434105	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:49434105G>C	uc001rta.3	-	31	7448	c.7448C>G	c.(7447-7449)TCT>TGT	p.S2483C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2483	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGGCTAGAGACCCAGCCTT	0.667		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			8	67					0	0	0	0
MYF5	4617	broad.mit.edu	37	12	81111152	81111152	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:81111152G>A	uc001szg.2	+	1	445	c.310G>A	c.(310-312)GAA>AAA	p.E104K		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	104	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CCAGGCTTTCGAAACCCTCAA	0.597		NA											25	77					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81693145	81693145	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:81693145C>A	uc001szo.1	-	23	2820	c.2659G>T	c.(2659-2661)GAA>TAA	p.E887*	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	813										ovary(3)|lung(2)|pancreas(1)	6						CTCCGAGCTTCTTCAAGAAGT	0.378		NA											3	13					0.004672	0.00490017	1	0
ATP2B1	490	broad.mit.edu	37	12	89995159	89995159	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:89995159T>A	uc001tbh.2	-	18	3293	c.3112A>T	c.(3112-3114)ATA>TTA	p.I1038L	ATP2B1_uc001tbg.2_Missense_Mutation_p.I1038L|ATP2B1_uc009zsr.2_5'Flank|ATP2B1_uc001tbf.2_Intron	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	1038	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						CACTGTTCTATTGAAAGTTCT	0.299		NA											60	196					0	0	0	0
PRKAB1	5564	broad.mit.edu	37	12	120111774	120111774	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:120111774A>G	uc009zwu.2	+	4	432	c.329A>G	c.(328-330)AAT>AGT	p.N110S	PRKAB1_uc001txg.2_Missense_Mutation_p.N110S	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	110					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	TGCAGCCACAATAACTTTGTA	0.522		NA											33	113					0	0	0	0
CAMKK2	10645	broad.mit.edu	37	12	121686456	121686456	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:121686456C>G	uc001tzu.2	-	14	1529	c.1405G>C	c.(1405-1407)GAG>CAG	p.E469Q	CAMKK2_uc001tzt.2_Missense_Mutation_p.E469Q|CAMKK2_uc001tzv.2_Missense_Mutation_p.E469Q|CAMKK2_uc001tzw.2_Intron|CAMKK2_uc001tzx.2_Missense_Mutation_p.E469Q|CAMKK2_uc001tzy.2_Intron|CAMKK2_uc001tzz.1_Missense_Mutation_p.E256Q|CAMKK2_uc001uaa.1_Missense_Mutation_p.E469Q|CAMKK2_uc001uab.2_Missense_Mutation_p.E469Q|CAMKK2_uc001uac.2_Intron	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	469					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCGACCTCCTCTTCAGTCACT	0.612		NA											34	204					0	0	0	0
MTUS2	23281	broad.mit.edu	37	13	29599467	29599467	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr13:29599467G>T	uc001usl.3	+	1	720	c.662G>T	c.(661-663)GGG>GTG	p.G221V		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	211						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CAGATACCTGGGGGTGGGGAG	0.607		NA											9	34					6.4e-05	7.08e-05	1	0
TRPC4	7223	broad.mit.edu	37	13	38320380	38320380	+	Silent	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr13:38320380G>C	uc001uws.2	-	3	826	c.591C>G	c.(589-591)CTC>CTG	p.L197L	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Silent_p.L197L|TRPC4_uc010tey.1_Silent_p.L197L|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Silent_p.L197L|TRPC4_uc010aby.2_Silent_p.L197L	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	197	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TGTAGATGTTGAGTCTGGAGC	0.527		NA											26	76					0	0	0	0
SLAIN1	122060	broad.mit.edu	37	13	78320898	78320898	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr13:78320898C>T	uc010thy.1	+	4	717	c.674C>T	c.(673-675)TCC>TTC	p.S225F	SLAIN1_uc001vkk.1_Missense_Mutation_p.S148F|SLAIN1_uc001vkl.1_Missense_Mutation_p.S104F|SLAIN1_uc010thz.1_Missense_Mutation_p.S103F|SLAIN1_uc010aex.1_Intron|SLAIN1_uc010aey.1_Intron|SLAIN1_uc001vkm.2_Missense_Mutation_p.S104F	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	367										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		AGCCCCAGTTCCCAGTATTTT	0.478		NA											54	97					0	0	0	0
OR4N2	390429	broad.mit.edu	37	14	20296147	20296147	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:20296147T>A	uc010tkv.1	+	1	540	c.540T>A	c.(538-540)GAT>GAA	p.D180E		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTCTGTGATGTCCCACAGG	0.542		NA											84	135					0	0	0	0
HOMEZ	57594	broad.mit.edu	37	14	23746104	23746104	+	Silent	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:23746104A>G	uc001wja.2	-	2	481	c.333T>C	c.(331-333)GGT>GGC	p.G111G	HOMEZ_uc001wjb.2_Silent_p.G113G	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	111	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ACCAGCTAATACCACAGCGGA	0.498		NA											6	244					0	0	0	0
RBM25	58517	broad.mit.edu	37	14	73566382	73566382	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:73566382T>G	uc001xno.2	+	9	999	c.791T>G	c.(790-792)ATA>AGA	p.I264R	RBM25_uc001xnn.3_Missense_Mutation_p.I264R|RBM25_uc010ttu.1_Missense_Mutation_p.I264R|RBM25_uc001xnp.2_Missense_Mutation_p.I59R	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	264					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TAGGAGGATATAAATGCTATA	0.358		NA											22	156					0	0	0	0
HEATR4	399671	broad.mit.edu	37	14	73973233	73973234	+	Nonsense_Mutation	DNP	GA	GA	TT			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:73973233_73973234GA>TT	uc010tub.1	-	10	2245_2246	c.1923_1924TC>AA	c.(1921-1926)TGTCAA>TGAAAA	p.641_642CQ>*K	HEATR4_uc010tua.1_Nonsense_Mutation_p.594_595CQ>*K	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TTCTTCCATTGACAGCTGTTCA	0.465		NA											33	169					0	0	0	0
NEK9	91754	broad.mit.edu	37	14	75562095	75562095	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:75562095C>T	uc001xrl.2	-	18	2367	c.2213G>A	c.(2212-2214)AGT>AAT	p.S738N	NEK9_uc001xrk.2_Missense_Mutation_p.S238N	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	738	Interaction with NEK6.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GGATAAGCCACTGCTATTGGA	0.388		NA											7	105					0	0	0	0
CYP46A1	10858	broad.mit.edu	37	14	100187605	100187605	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:100187605G>A	uc001ygo.2	+	11	1010	c.1010G>A	c.(1009-1011)GGT>GAT	p.G337D	CYP46A1_uc001ygp.2_Missense_Mutation_p.G184D	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	337					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GAGGTCATTGGTTCTAAGAGG	0.547		NA											16	75					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113097	42113097	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr15:42113097G>A	uc001zok.3	+	24	2853	c.2567G>A	c.(2566-2568)CGC>CAC	p.R856H	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R850H|MAPKBP1_uc010bcj.2_Missense_Mutation_p.R357H|MAPKBP1_uc010bci.2_Missense_Mutation_p.R850H|MAPKBP1_uc010udb.1_Missense_Mutation_p.R689H|MAPKBP1_uc010bck.2_Missense_Mutation_p.R67H|MAPKBP1_uc010bcl.2_Missense_Mutation_p.R357H	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	856										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGAAGAGGGCGCTGGGTTCAG	0.637		NA											13	52					0	0	0	0
C15orf33	196951	broad.mit.edu	37	15	49882141	49882141	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr15:49882141T>C	uc001zxl.2	-	4	463	c.169A>G	c.(169-171)ATA>GTA	p.I57V	C15orf33_uc001zxm.2_Missense_Mutation_p.I57V	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	57				I -> M (in Ref. 1; BAB71451).						ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TCTTCTTTTATTTTTTTCAGA	0.318		NA											26	129					0	0	0	0
CILP	8483	broad.mit.edu	37	15	65494259	65494259	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr15:65494259C>G	uc002aon.2	-	8	1318	c.1137G>C	c.(1135-1137)CAG>CAC	p.Q379H		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	379	Ig-like C2-type.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CAGCATCACTCTGGGCCTTGC	0.572		NA											11	46					0	0	0	0
SEPT12	124404	broad.mit.edu	37	16	4835848	4835848	+	Missense_Mutation	SNP	C	C	G	rs141666105		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:4835848C>G	uc002cxq.2	-	4	475	c.334G>C	c.(334-336)GAC>CAC	p.D112H	SEPT12_uc002cxr.2_Missense_Mutation_p.D112H|SEPT12_uc010bty.2_RNA|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	112					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity	p.D112N(1)		skin(1)	1						CCGGGCGTGTCCGTCACCGTC	0.363		NA											24	88					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18852958	18852958	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:18852958C>A	uc002dfm.2	-	41	6988	c.6625G>T	c.(6625-6627)GAT>TAT	p.D2209Y	SMG1_uc010bwb.2_Missense_Mutation_p.D2069Y|SMG1_uc010bwa.2_Missense_Mutation_p.D940Y|SMG1_uc002dfo.3_Missense_Mutation_p.D507Y	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2209	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GTGGCTCCATCTACCCACTGG	0.433		NA											47	171					4.01e-20	4.79e-20	1	0
CETP	1071	broad.mit.edu	37	16	56996954	56996954	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:56996954G>T	uc002eki.2	+	2	208	c.151G>T	c.(151-153)GCC>TCC	p.A51S	CETP_uc002ekj.2_Missense_Mutation_p.A51S	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	51					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						GATCCAGACCGCCTTCCAGCG	0.622		NA											12	67					1.36e-13	1.59e-13	1	0
ZFPM1	161882	broad.mit.edu	37	16	88598565	88598565	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:88598565C>T	uc002fkv.2	+	7	901	c.868C>T	c.(868-870)CGC>TGC	p.R290C		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	290	C2H2-type 1.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CCCCAACGAGCGCGTCTGCCC	0.716		NA											7	46					0	0	0	0
CDH15	1013	broad.mit.edu	37	16	89254553	89254553	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:89254553C>T	uc002fmt.2	+	7	915	c.838C>T	c.(838-840)CGC>TGC	p.R280C		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	280	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGATGTGGGACGCCTGGAAGT	0.647		NA											4	40					0	0	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351208	89351208	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:89351208G>C	uc002fmx.1	-	9	2203	c.1742C>G	c.(1741-1743)TCT>TGT	p.S581C	ANKRD11_uc002fmy.1_Missense_Mutation_p.S581C|ANKRD11_uc002fnc.1_Missense_Mutation_p.S581C|ANKRD11_uc002fnb.1_Missense_Mutation_p.S538C	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	581	Ser-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGAGCCCTCAGAGGAGTAGTC	0.547		NA											12	69					0	0	0	0
GAS7	8522	broad.mit.edu	37	17	9820581	9820581	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:9820581C>G	uc002gmg.1	-	14	1556	c.1395G>C	c.(1393-1395)AAG>AAC	p.K465N	GAS7_uc010vvc.1_Missense_Mutation_p.K279N|GAS7_uc002gmh.1_Missense_Mutation_p.K325N|GAS7_uc010vvd.1_Missense_Mutation_p.K417N|GAS7_uc002gmi.2_Missense_Mutation_p.K401N|GAS7_uc002gmj.1_Missense_Mutation_p.K405N|GAS7_uc010coh.1_Missense_Mutation_p.K405N	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	465					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						TGTTGCCCGTCTTGTGCTCTC	0.627		NA	T	MLL	AML*								17	68					0	0	0	0
TMIGD1	388364	broad.mit.edu	37	17	28645840	28645840	+	Silent	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:28645840C>T	uc002hfa.1	-	5	805	c.732G>A	c.(730-732)AAG>AAA	p.K244K	TMIGD1_uc010csh.1_Intron	NM_206832	NP_996663	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain	244	Cytoplasmic (Potential).					integral to membrane					0						TCATTATTTTCTTTCTTCTAG	0.353		NA											28	104					0	0	0	0
ACCN1	40	broad.mit.edu	37	17	32483260	32483260	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:32483260G>A	uc002hhu.2	-	1	566	c.292C>T	c.(292-294)CGG>TGG	p.R98W		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	98	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	CTGGAGAACCGGAAGCCATTC	0.582		NA											15	46					0	0	0	0
FAM134C	162427	broad.mit.edu	37	17	40761276	40761276	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:40761276G>A	uc002ial.2	-	1	170	c.67C>T	c.(67-69)CGA>TGA	p.R23*	TUBG1_uc002ian.2_5'Flank|FAM134C_uc010wgq.1_5'UTR|FAM134C_uc002iam.1_5'UTR|FAM134C_uc010cyk.1_Intron	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	23						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		GACACATCTCGGCGGCCCCTG	0.711		NA											29	20					0	0	0	0
RGS9	8787	broad.mit.edu	37	17	63156694	63156694	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:63156694A>G	uc002jfe.2	+	5	463	c.353A>G	c.(352-354)GAT>GGT	p.D118G	RGS9_uc010dem.2_Missense_Mutation_p.D118G|RGS9_uc002jfd.2_Missense_Mutation_p.D118G|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	118					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCAGCTGAAGATACCGATTAC	0.463		NA											12	60					0	0	0	0
MC2R	4158	broad.mit.edu	37	18	13885247	13885247	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr18:13885247A>T	uc002ksp.1	-	2	448	c.271T>A	c.(271-273)TAT>AAT	p.Y91N		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	91	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	GGCTTGAGATAGCCCATGTTT	0.458		NA											20	105					0	0	0	0
FBXO15	201456	broad.mit.edu	37	18	71797721	71797721	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr18:71797721C>T	uc002lle.2	-	4	613	c.277G>A	c.(277-279)GCA>ACA	p.A93T	FBXO15_uc002llf.2_Missense_Mutation_p.A169T	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	93										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TCAGCTAGTGCGGCTTTTACA	0.418		NA											3	83					0	0	0	0
ARRDC2	27106	broad.mit.edu	37	19	18121139	18121139	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:18121139G>T	uc002nhv.2	+	6	1127	c.984G>T	c.(982-984)AGG>AGT	p.R328S	ARRDC2_uc002nhu.2_Missense_Mutation_p.R323S	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	328										pancreas(1)	1						TGGACTGGAGGCTGGGGGCCT	0.647		NA											12	33					4.75e-09	5.4e-09	1	0
GPI	2821	broad.mit.edu	37	19	34859497	34859497	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:34859497G>T	uc002nvg.1	+	4	395	c.292G>T	c.(292-294)GTG>TTG	p.V98L	GPI_uc002nvf.2_Missense_Mutation_p.V137L|GPI_uc010xrv.1_Missense_Mutation_p.V137L|GPI_uc010xrw.1_Missense_Mutation_p.V98L|GPI_uc010edl.1_Missense_Mutation_p.V98L|GPI_uc002nvh.1_3'UTR	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	98					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					GGGTCGAGCCGTGCTGCACGT	0.597		NA											8	71					1.13e-05	1.26e-05	1	0
FFAR3	2865	broad.mit.edu	37	19	35850648	35850648	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:35850648G>A	uc002nzd.2	+	2	931	c.856G>A	c.(856-858)GAC>AAC	p.D286N	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	286	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GTTCCAAGCCGACTTTCATGA	0.597		NA											12	92					0	0	0	0
ZNF567	163081	broad.mit.edu	37	19	37210997	37210997	+	Silent	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:37210997C>A	uc010xtl.1	+	6	1593	c.1371C>A	c.(1369-1371)TCC>TCA	p.S457S	ZNF567_uc002oeo.1_Silent_p.S457S|ZNF567_uc010xtk.1_Silent_p.S457S|ZNF567_uc002oep.3_Silent_p.S426S|ZNF567_uc002oeq.1_Silent_p.S426S	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	457	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTGGAAAGTCCTTCCGCCAGA	0.428		NA											38	73					3.39e-10	3.91e-10	1	0
MARK4	57787	broad.mit.edu	37	19	45768123	45768123	+	Silent	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:45768123G>A	uc002pbb.1	+	6	452	c.447G>A	c.(445-447)TCG>TCA	p.S149S	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.S149S|MARK4_uc002pbc.1_Silent_p.S15S			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	149	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACCTCGTGTCGCATGGCCGCA	0.677		NA											13	147					0	0	0	0
APOB	338	broad.mit.edu	37	2	21228715	21228715	+	Silent	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:21228715G>T	uc002red.2	-	26	11153	c.11025C>A	c.(11023-11025)ATC>ATA	p.I3675I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3675					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGTAGGATGATATTTTTGA	0.458		NA											58	87					1.18e-23	1.41e-23	1	0
LTBP1	4052	broad.mit.edu	37	2	33500964	33500964	+	Missense_Mutation	SNP	G	G	C	rs142262862		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:33500964G>C	uc002ros.2	+	18	2969	c.2969G>C	c.(2968-2970)CGC>CCC	p.R990P	LTBP1_uc002rot.2_Missense_Mutation_p.R664P|LTBP1_uc002rou.2_Missense_Mutation_p.R663P|LTBP1_uc002rov.2_Missense_Mutation_p.R610P|LTBP1_uc010ymz.1_Missense_Mutation_p.R663P|LTBP1_uc010yna.1_Missense_Mutation_p.R610P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	989	EGF-like 6; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGCGGGTACCGCATGACTCAG	0.572		NA											27	121					0	0	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657152	40657152	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:40657152A>C	uc002rrx.2	-	1	293	c.269T>G	c.(268-270)CTT>CGT	p.L90R	SLC8A1_uc002rry.2_Missense_Mutation_p.L90R|SLC8A1_uc002rrz.2_Missense_Mutation_p.L90R|SLC8A1_uc002rsa.2_Missense_Mutation_p.L90R|SLC8A1_uc002rsd.3_Missense_Mutation_p.L90R|SLC8A1_uc002rsb.1_Missense_Mutation_p.L90R|SLC8A1_uc010fan.1_Missense_Mutation_p.L90R|SLC8A1_uc002rsc.1_Missense_Mutation_p.L90R	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	90	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGAGACTCCAAGAAACATGTA	0.423		NA											88	115					0	0	0	0
UBXN4	23190	broad.mit.edu	37	2	136499550	136499550	+	Silent	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:136499550G>A	uc002tur.2	+	1	362	c.51G>A	c.(49-51)AGG>AGA	p.R17R		NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	17	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						CGGCCAAAAGGAGCGGCGCGG	0.672		NA											6	22					0	0	0	0
GPD2	2820	broad.mit.edu	37	2	157426617	157426617	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:157426617G>C	uc002tzf.3	+	12	1855	c.1495G>C	c.(1495-1497)GCC>CCC	p.A499P	GPD2_uc010zch.1_Missense_Mutation_p.A272P|GPD2_uc002tzd.3_Missense_Mutation_p.A499P|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	499					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GCATCTTGCCGCCACCTATGG	0.458		NA											22	119					0	0	0	0
DPP4	1803	broad.mit.edu	37	2	162849867	162849867	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:162849867C>T	uc002ubz.2	-	26	2788	c.2227G>A	c.(2227-2229)GCT>ACT	p.A743T	DPP4_uc010fpb.2_Missense_Mutation_p.A419T	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	743	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	GTGCTGCTAGCTATTCCATGG	0.343		NA											47	193					0	0	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170711	207170711	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:207170711T>G	uc002vbp.2	+	5	1709	c.1459T>G	c.(1459-1461)TAT>GAT	p.Y487D		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	487							nucleic acid binding|zinc ion binding			ovary(3)	3						TGACCAAAGCTATGAATCTAG	0.383		NA											4	72					0	0	0	0
RBM44	375316	broad.mit.edu	37	2	238726675	238726675	+	Silent	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:238726675C>G	uc002vxi.3	+	3	1248	c.1116C>G	c.(1114-1116)CTC>CTG	p.L372L		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	371							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGACATTACTCCAACCCTGTA	0.353		NA											34	110					0	0	0	0
ZNF337	26152	broad.mit.edu	37	20	25656794	25656794	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:25656794G>A	uc002wva.2	-	4	1652	c.1130C>T	c.(1129-1131)GCG>GTG	p.A377V	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.A345V|ZNF337_uc002wvb.2_Missense_Mutation_p.A377V|ZNF337_uc002wvc.2_Missense_Mutation_p.A377V	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	377	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGCCTGCACGCAAAGGGCTT	0.512		NA											25	130					0	0	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32212735	32212735	+	Silent	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:32212735C>T	uc002wzg.1	+	7	1422	c.885C>T	c.(883-885)ACC>ACT	p.T295T	CBFA2T2_uc010zug.1_Silent_p.T69T|CBFA2T2_uc002wze.1_Silent_p.T286T|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.T266T|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	295						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						AGCATTACACCTTAGAGGATA	0.532		NA											45	80					0	0	0	0
RBL1	5933	broad.mit.edu	37	20	35717398	35717398	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:35717398T>G	uc002xgi.2	-	2	363	c.284A>C	c.(283-285)AAA>ACA	p.K95T	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.K95T|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	95					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TTACCTTAATTTAGCTGAACG	0.323		NA											65	106					0	0	0	0
RALGAPB	57148	broad.mit.edu	37	20	37144953	37144953	+	Silent	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:37144953C>T	uc002xiw.2	+	7	1248	c.991C>T	c.(991-993)CTG>TTG	p.L331L	RALGAPB_uc010zvz.1_Silent_p.L331L|RALGAPB_uc002xix.2_Silent_p.L331L|RALGAPB_uc002xiy.1_Silent_p.L331L|RALGAPB_uc002xiz.2_Silent_p.L109L|RALGAPB_uc002xja.1_Silent_p.L58L	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	331					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						CCTTAAACATCTGCCTCAAAT	0.413		NA											54	419					0	0	0	0
TP53RK	112858	broad.mit.edu	37	20	45315819	45315819	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:45315819T>C	uc002xsk.2	-	2	558	c.335A>G	c.(334-336)TAT>TGT	p.Y112C	SLC13A3_uc002xsg.1_5'Flank|SLC13A3_uc010gho.1_5'Flank|TP53RK_uc002xsj.2_Missense_Mutation_p.I114V	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	p53-related protein kinase	112	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Myeloproliferative disorder(115;0.0122)				TTCTTCCATATATAAGCAGTT	0.403		NA											108	477					0	0	0	0
RUNX1	861	broad.mit.edu	37	21	36206846	36206846	+	Silent	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr21:36206846G>A	uc002yuh.2	-	4	2163	c.585C>T	c.(583-585)TCC>TCT	p.S195S	RUNX1_uc002yui.2_Intron|RUNX1_uc010gmu.2_Silent_p.S222S|RUNX1_uc010gmv.2_Silent_p.S222S|RUNX1_uc002yuj.3_Silent_p.S90S|RUNX1_uc002yuk.3_Silent_p.S222S|RUNX1_uc002yul.1_5'UTR|RUNX1_uc002yum.1_Intron|RUNX1_uc010gmw.1_Silent_p.S222S|RUNX1_uc002yuo.1_Silent_p.S195S	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	195	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.I195fs*19(1)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TGAGCCGCTCGGAAAAGGACA	0.517		NA	T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				25	126					0	0	0	0
TNRC6B	23112	broad.mit.edu	37	22	40719213	40719213	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr22:40719213G>A	uc011aor.1	+	23	5681	c.5470G>A	c.(5470-5472)GAC>AAC	p.D1824N	TNRC6B_uc003aym.2_Missense_Mutation_p.D1020N|TNRC6B_uc003ayn.3_Missense_Mutation_p.D1714N	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1824					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						ACTACCTGGTGACCTTCTGGG	0.502		NA											27	58					0	0	0	0
SLC4A7	9497	broad.mit.edu	37	3	27490193	27490193	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:27490193T>A	uc003cdv.2	-	3	282	c.211A>T	c.(211-213)AGA>TGA	p.R71*	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Nonsense_Mutation_p.R76*|SLC4A7_uc011aww.1_Nonsense_Mutation_p.R80*|SLC4A7_uc011awx.1_Nonsense_Mutation_p.R80*|SLC4A7_uc011awy.1_Nonsense_Mutation_p.R76*|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Nonsense_Mutation_p.R76*|SLC4A7_uc011axb.1_Nonsense_Mutation_p.R80*|SLC4A7_uc010hfm.2_Nonsense_Mutation_p.R76*|SLC4A7_uc003cdw.2_Nonsense_Mutation_p.R71*	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	71	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TTATCTTTTCTTCTCCGGTGG	0.408		NA											78	71					0	0	0	0
ABHD5	51099	broad.mit.edu	37	3	43756504	43756504	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:43756504G>A	uc003cmx.2	+	5	837	c.727G>A	c.(727-729)GAT>AAT	p.D243N		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	243					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		GTTCGAAGACGATACTGTGAC	0.318		NA											31	101					0	0	0	0
ZNF167	55888	broad.mit.edu	37	3	44612216	44612216	+	Silent	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:44612216C>G	uc010hin.2	+	6	2002	c.1614C>G	c.(1612-1614)CTC>CTG	p.L538L	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Silent_p.L538L|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	538	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		ATAGAAATCTCATTGACCATC	0.448		NA											39	135					0	0	0	0
HESX1	8820	broad.mit.edu	37	3	57232884	57232884	+	Missense_Mutation	SNP	G	G	A	rs149663188		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:57232884G>A	uc003din.3	-	2	588	c.254C>T	c.(253-255)TCG>TTG	p.S85L		NM_003865	NP_003856	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	85						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		TTCATATTTCGAAGCTCTTTC	0.418		NA											128	367					0	0	0	0
IFT57	55081	broad.mit.edu	37	3	107941068	107941068	+	Silent	SNP	G	G	T	rs150114125		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:107941068G>T	uc003dwx.3	-	1	350	c.102C>A	c.(100-102)CCC>CCA	p.P34P		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	34					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			AGGCCGCGCCGGGCCCCCGCT	0.637		NA											21	43					3.84e-06	4.32e-06	1	0
NR1I2	8856	broad.mit.edu	37	3	119533912	119533912	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:119533912C>T	uc003edj.2	+	6	2720	c.881C>T	c.(880-882)GCG>GTG	p.A294V	NR1I2_uc003edi.2_Missense_Mutation_p.A257V|NR1I2_uc003edk.2_Missense_Mutation_p.A333V|NR1I2_uc003edl.2_Missense_Mutation_p.A182V	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	294	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	GTGTTCAATGCGGAGACTGGA	0.597		NA											16	94					0	0	0	0
EEFSEC	60678	broad.mit.edu	37	3	128060189	128060189	+	Silent	SNP	C	C	T	rs114698998	byFrequency	TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:128060189C>T	uc003eki.2	+	5	938	c.900C>T	c.(898-900)CGC>CGT	p.R300R	EEFSEC_uc003ekj.2_Silent_p.R245R	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	300						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						TGCTGGAGCGCGGGTTGGTGT	0.592		NA											42	99					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130292957	130292957	+	Silent	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:130292957C>T	uc010htl.2	+	7	3166	c.3135C>T	c.(3133-3135)AGC>AGT	p.S1045S		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1045	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCCAGTTTAGCGATACCTATC	0.418		NA											24	55					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	T	rs121913279		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:178952085A>T	uc003fjk.2	+	21	3297	c.3140A>T	c.(3139-3141)CAT>CTT	p.H1047L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	75					0	0	0	0
KLHL6	89857	broad.mit.edu	37	3	183210339	183210339	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:183210339G>A	uc003flr.2	-	6	1565	c.1507C>T	c.(1507-1509)CCC>TCC	p.P503S	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	503	Kelch 4.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GCCTCCACGGGCATGGCCGCC	0.517		NA											4	146					0	0	0	0
CRYGS	1427	broad.mit.edu	37	3	186257359	186257359	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:186257359G>C	uc003fqe.2	-	2	101	c.49C>G	c.(49-51)CAA>GAA	p.Q17E	CRYGS_uc003fqf.2_Missense_Mutation_p.Q17E	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	17	Beta/gamma crystallin 'Greek key' 1.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		CGACGGCCTTGAAAATTTTTG	0.433		NA											23	99					0	0	0	0
CRMP1	1400	broad.mit.edu	37	4	5862807	5862807	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:5862807C>G	uc003gip.2	-	4	360	c.259G>C	c.(259-261)GAT>CAT	p.D87H	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Missense_Mutation_p.D87H|CRMP1_uc003gir.2_Missense_Mutation_p.D82H|CRMP1_uc003gis.2_Missense_Mutation_p.D201H	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	87					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		AAGAAGTCATCAGCCGCAGTC	0.572		NA											30	68					0	0	0	0
UGDH	7358	broad.mit.edu	37	4	39523092	39523092	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:39523092T>C	uc003guk.1	-	2	357	c.41A>G	c.(40-42)TAT>TGT	p.Y14C	UGDH_uc011byp.1_Intron|UGDH_uc003gul.1_Missense_Mutation_p.Y14C	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	14	NAD.				glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TCCTCCAACATAGCCTGCACC	0.373		NA											28	97					0	0	0	0
GRXCR1	389207	broad.mit.edu	37	4	42965026	42965026	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:42965026G>A	uc003gwt.2	+	2	502	c.502G>A	c.(502-504)GTA>ATA	p.V168I		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	168	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						AAACCATCGCGTAAAATTTGA	0.428		NA											5	325					0	0	0	0
PROL1	58503	broad.mit.edu	37	4	71275443	71275443	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:71275443T>C	uc003hfi.2	+	3	572	c.398T>C	c.(397-399)ATT>ACT	p.I133T		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	133	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				TTTCTTGCTATTTACCTTCCT	0.443		NA											56	210					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114294489	114294489	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:114294489A>C	uc003ibe.3	+	45	11843	c.11743A>C	c.(11743-11745)AAA>CAA	p.K3915Q	ANK2_uc003ibd.3_Missense_Mutation_p.K1821Q|ANK2_uc003ibf.3_Missense_Mutation_p.K1830Q|ANK2_uc011cgc.1_Missense_Mutation_p.K1006Q|ANK2_uc003ibg.3_Missense_Mutation_p.K845Q|ANK2_uc003ibh.3_Missense_Mutation_p.K535Q|ANK2_uc011cgd.1_Missense_Mutation_p.K1217Q|ANK2_uc010imr.2_5'UTR|ANK2_uc010ims.2_5'UTR	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3882					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGGCACAGAGAAAGAAGAGAT	0.403		NA											57	88					0	0	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005580	118005580	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:118005580C>A	uc003ibv.3	-	1	1157	c.970G>T	c.(970-972)GTA>TTA	p.V324L		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	324	Cytoplasmic (Potential).|TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						GAATCTTCTACCCACCTCTGA	0.408		NA											135	198					1.86e-60	2.25e-60	1	0
DCHS2	54798	broad.mit.edu	37	4	155156833	155156833	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:155156833C>A	uc003inw.2	-	25	7606	c.7606G>T	c.(7606-7608)GCC>TCC	p.A2536S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2536					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAGCTGCTGGCGAACACTGCC	0.393		NA											16	94					1.03e-11	1.19e-11	1	0
TKTL2	84076	broad.mit.edu	37	4	164393537	164393537	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:164393537G>C	uc003iqp.3	-	1	1511	c.1350C>G	c.(1348-1350)TTC>TTG	p.F450L		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	450						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CACTTGGATAGAAAACAGTAC	0.488		NA											39	131					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13721351	13721351	+	Missense_Mutation	SNP	G	G	A	rs148349630		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:13721351G>A	uc003jfd.2	-	71	12079	c.12037C>T	c.(12037-12039)CGC>TGC	p.R4013C	DNAH5_uc003jfc.2_Missense_Mutation_p.R181C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4013	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGTACTTGCGGGCCTGCCAA	0.328		NA							Kartagener_syndrome				52	84					0	0	0	0
MAP3K1	4214	broad.mit.edu	37	5	56170929	56170929	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:56170929G>A	uc003jqw.3	+	10	2258	c.1757G>A	c.(1756-1758)CGT>CAT	p.R586H		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	586					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GCCCTCAGGCGTCTTTCCCAT	0.527		NA											48	277					0	0	0	0
HTR1A	3350	broad.mit.edu	37	5	63256858	63256858	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:63256858A>G	uc011cqt.1	-	1	689	c.689T>C	c.(688-690)GTC>GCC	p.V230A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	230	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CACCTTTTTGACCGTCTTGCG	0.587		NA											4	99					0	0	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101606380	101606380	+	Silent	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:101606380T>A	uc003knm.2	-	3	1037	c.750A>T	c.(748-750)GGA>GGT	p.G250G		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	250	Helical; Name=4; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GAAAGGCTGTTCCCAGAGTAT	0.388		NA											9	104					0	0	0	0
DMXL1	1657	broad.mit.edu	37	5	118469800	118469800	+	Silent	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:118469800G>A	uc003ksd.2	+	12	2362	c.2181G>A	c.(2179-2181)CGG>CGA	p.R727R	DMXL1_uc010jcl.1_Silent_p.R727R|DMXL1_uc003ksc.1_Silent_p.R727R	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	727										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AGCTTGCCCGGATTAATTCTC	0.443		NA											26	257					0	0	0	0
PRR16	51334	broad.mit.edu	37	5	120021755	120021755	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:120021755C>A	uc003ksq.2	+	2	429	c.266C>A	c.(265-267)GCC>GAC	p.A89D	PRR16_uc003ksp.2_Missense_Mutation_p.A66D|PRR16_uc003ksr.2_Missense_Mutation_p.A19D	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	89										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GGCACAACAGCCTCCAGCCTA	0.527		NA											42	75					2.66e-13	3.1e-13	1	0
NR3C1	2908	broad.mit.edu	37	5	142779539	142779539	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:142779539G>A	uc003lmz.2	-	2	1358	c.866C>T	c.(865-867)CCT>CTT	p.P289L	NR3C1_uc003lmy.2_Missense_Mutation_p.P289L|NR3C1_uc003lna.2_Missense_Mutation_p.P289L|NR3C1_uc003lnb.2_Missense_Mutation_p.P289L|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Missense_Mutation_p.P289L|NR3C1_uc003lnd.2_Missense_Mutation_p.P289L|NR3C1_uc003lne.2_Missense_Mutation_p.P289L|NR3C1_uc003lnf.2_Missense_Mutation_p.P289L|NR3C1_uc003lng.2_Missense_Mutation_p.P289L|NR3C1_uc003lnh.2_Missense_Mutation_p.P289L|NR3C1_uc003lni.2_Missense_Mutation_p.P289L	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	289	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	AATTACCCCAGGGGTGCAGAG	0.398		NA											7	331					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150925174	150925174	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:150925174G>T	uc003lue.3	-	9	5527	c.5514C>A	c.(5512-5514)TTC>TTA	p.F1838L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1838	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATAGACACAGAATTGGAAAG	0.463		NA											27	135					1.4e-14	1.65e-14	1	0
GABRP	2568	broad.mit.edu	37	5	170222219	170222219	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:170222219C>A	uc003mau.2	+	5	446	c.248C>A	c.(247-249)ACA>AAA	p.T83K	GABRP_uc011dev.1_Missense_Mutation_p.T83K	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	83	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGGACTACACAGCCACCATA	0.567		NA											13	274					8.6e-14	1.01e-13	1	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726458	25726458	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:25726458C>T	uc003nfc.2	-	1	333	c.298G>A	c.(298-300)GGC>AGC	p.G100S	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	100					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ATGGTCACGCCGCCCAAAAGC	0.532		NA											123	207					0	0	0	0
TRIM27	5987	broad.mit.edu	37	6	28872383	28872383	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:28872383G>A	uc003nlr.2	-	8	1365	c.1006C>T	c.(1006-1008)CGG>TGG	p.R336W	TRIM27_uc003nls.2_Missense_Mutation_p.R336W|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	336	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						CGCACTTGCCGCAGATTATCA	0.577		NA	T	RET	papillary thyroid								9	53					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32038061	32038061	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:32038061C>A	uc003nzl.2	-	14	5323	c.5121G>T	c.(5119-5121)CAG>CAT	p.Q1707H		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1789	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TGTCCTTGAACTGGACCACAA	0.637		NA											10	23					0.000673444	0.000723151	1	0
ATF6B	1388	broad.mit.edu	37	6	32093996	32093996	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:32093996T>A	uc003nzn.2	-	5	409	c.376A>T	c.(376-378)ACA>TCA	p.T126S	ATF6B_uc003nzo.2_Missense_Mutation_p.T123S|ATF6B_uc011dpg.1_Missense_Mutation_p.T60S|ATF6B_uc011dph.1_Missense_Mutation_p.T126S	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	126	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGGACTCTGTCTTCACATGG	0.542		NA											49	71					0	0	0	0
C6orf165	154313	broad.mit.edu	37	6	88138453	88138453	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:88138453A>G	uc003plv.2	+	9	1162	c.1070A>G	c.(1069-1071)CAC>CGC	p.H357R	C6orf165_uc003plw.2_Missense_Mutation_p.H169R|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.H357R	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	357										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TTGGGTGCTCACGAACTATAC	0.408		NA											85	134					0	0	0	0
SLC16A10	117247	broad.mit.edu	37	6	111498518	111498518	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:111498518C>T	uc003pus.2	+	3	767	c.592C>T	c.(592-594)CGC>TGC	p.R198C	SLC16A10_uc003pur.3_Missense_Mutation_p.R198C|SLC16A10_uc003put.2_5'UTR	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	198	Extracellular (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		TTTCAAGAAGCGCCTTGGACT	0.498		NA											38	107					0	0	0	0
TXLNB	167838	broad.mit.edu	37	6	139568987	139568987	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:139568987C>A	uc011eds.1	-	8	1302	c.1137G>T	c.(1135-1137)GAG>GAT	p.E379D		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	379	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TGGCAAACACCTCGTTGCTTT	0.383		NA											4	180					0.00024832	0.000271168	1	0
ARID1B	57492	broad.mit.edu	37	6	157528336	157528336	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:157528336A>G	uc003qqn.2	+	20	6159	c.6007A>G	c.(6007-6009)AGG>GGG	p.R2003G	ARID1B_uc003qqo.2_Missense_Mutation_p.R1963G|ARID1B_uc003qqp.2_Missense_Mutation_p.R1950G	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2008					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CGAGGTCTTGAGGGATAACAC	0.542		NA											3	126					0	0	0	0
FAM120B	84498	broad.mit.edu	37	6	170626814	170626814	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:170626814A>G	uc003qxp.2	+	2	444	c.336A>G	c.(334-336)ATA>ATG	p.I112M	FAM120B_uc003qxo.1_Missense_Mutation_p.I112M|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	112					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		ACAGGGAGATATCCAGGATTT	0.453		NA											40	114					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4051785	4051785	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:4051785C>T	uc003smx.2	+	16	2477	c.2338C>T	c.(2338-2340)CGG>TGG	p.R780W	SDK1_uc010kso.2_Missense_Mutation_p.R56W	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	780	Fibronectin type-III 2.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGCCAGTGGGCGGACTAATCA	0.512		NA											6	318					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11418786	11418786	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:11418786A>G	uc003ssf.3	-	25	4964	c.4712T>C	c.(4711-4713)GTG>GCG	p.V1571A	uc003ssb.2_Intron|THSD7A_uc003ssd.3_Missense_Mutation_p.V75A	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1571	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACTGGTTTTCACATCTCCTCT	0.522		NA								HNSCC(18;0.044)			24	152					0	0	0	0
TXNDC3	51314	broad.mit.edu	37	7	37927910	37927910	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:37927910C>T	uc003tfn.2	+	15	1651	c.1279C>T	c.(1279-1281)CCG>TCG	p.P427S		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	427	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GGACAGTTTGCCGGTCAACCA	0.368		NA							Kartagener_syndrome				4	180					0	0	0	0
EPDR1	54749	broad.mit.edu	37	7	37989814	37989814	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:37989814T>A	uc003tfp.2	+	3	870	c.851T>A	c.(850-852)ATT>AAT	p.I284N	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Missense_Mutation_p.I103N	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	164					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GAAACCTGGATTGGCATCTAT	0.318		NA											11	109					0	0	0	0
ADCY1	107	broad.mit.edu	37	7	45750144	45750144	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:45750144G>T	uc003tne.3	+	19	2968	c.2950G>T	c.(2950-2952)GTG>TTG	p.V984L		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	984	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTTGGCCCTGTGGTGGCTGG	0.582		NA											18	101					1.11e-09	1.27e-09	1	0
IGFBP3	3486	broad.mit.edu	37	7	45956911	45956911	+	Silent	SNP	T	T	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:45956911T>C	uc003tns.2	-	2	663	c.531A>G	c.(529-531)AAA>AAG	p.K177K	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Silent_p.K183K|IGFBP3_uc003tnt.2_Silent_p.K80K	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	177					negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	TAGCATGCCCTTTCTTGATGA	0.547		NA									OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	116	162					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82764455	82764455	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:82764455T>G	uc003uhx.2	-	3	2700	c.2411A>C	c.(2410-2412)CAG>CCG	p.Q804P	PCLO_uc003uhv.2_Missense_Mutation_p.Q804P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	750	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGAAAACTCTGTGAGGGTTT	0.433		NA											80	185					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86415678	86415678	+	Silent	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:86415678C>T	uc003uid.2	+	3	1669	c.570C>T	c.(568-570)ACC>ACT	p.T190T	GRM3_uc010lef.2_Silent_p.T188T|GRM3_uc010leg.2_Silent_p.T62T|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	190	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTGCCAGGACCGTGCCCCCCG	0.567		NA											41	153					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103252122	103252122	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:103252122A>T	uc003vca.2	-	21	2991	c.2831T>A	c.(2830-2832)ATG>AAG	p.M944K	RELN_uc010liz.2_Missense_Mutation_p.M944K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	944					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGGTTGTCCATGTGTGGGGT	0.463		NA											32	46					0	0	0	0
GPR22	2845	broad.mit.edu	37	7	107115239	107115239	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:107115239G>A	uc003vef.2	+	3	2080	c.734G>A	c.(733-735)AGA>AAA	p.R245K	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	245	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						ATAGGCACAAGATTTTCAACA	0.378		NA											14	52					0	0	0	0
NOM1	64434	broad.mit.edu	37	7	156755792	156755792	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:156755792G>T	uc003wmy.2	+	6	1849	c.1834G>T	c.(1834-1836)GTG>TTG	p.V612L	NOM1_uc010lqp.1_Missense_Mutation_p.V61L	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	612					RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CTGGTGGATTGTGGGGTCCGC	0.622		NA											17	46					6.94e-10	7.95e-10	1	0
DOCK5	80005	broad.mit.edu	37	8	25166333	25166333	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:25166333C>G	uc003xeg.2	+	12	1221	c.1084C>G	c.(1084-1086)CTC>GTC	p.L362V	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.L76V|DOCK5_uc003xei.2_5'Flank	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	362						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CCAGAGGCAGCTCATCATGTC	0.468		NA											27	26					0	0	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70591756	70591756	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:70591756C>G	uc003xyl.2	-	8	2588	c.1881G>C	c.(1879-1881)AAG>AAC	p.K627N	SLCO5A1_uc010lzb.2_Missense_Mutation_p.K572N|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.K627N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	627	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGAGATAAGTCTTGACAATAA	0.448		NA											47	229					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73480489	73480489	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:73480489G>C	uc003xzb.2	+	2	1108	c.520G>C	c.(520-522)GAT>CAT	p.D174H		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	174	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CTGCTGCCCTGATAAAAGGAA	0.438		NA											37	212					0	0	0	0
FABP5	2171	broad.mit.edu	37	8	82195651	82195651	+	Missense_Mutation	SNP	A	A	G	rs145774881		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:82195651A>G	uc003yca.1	+	2	178	c.130A>G	c.(130-132)ATC>GTC	p.I44V		NM_001444	NP_001435	Q01469	FABP5_HUMAN	fatty acid binding protein 5	44					epidermis development	cytoplasm	fatty acid binding|protein binding|transporter activity				0	Lung NSC(7;3.57e-05)|all_lung(9;0.00011)		Epithelial(68;0.102)			GCCAGATTGTATCATCACTTG	0.393		NA											9	93					0	0	0	0
KCNS2	3788	broad.mit.edu	37	8	99440425	99440425	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:99440425G>A	uc003yin.2	+	2	568	c.218G>A	c.(217-219)CGC>CAC	p.R73H		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	73	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TACTTCGACCGCAACCCTGAG	0.597		NA											5	249					0	0	0	0
MTSS1	9788	broad.mit.edu	37	8	125577991	125577991	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:125577991C>G	uc003yrk.2	-	9	1270	c.736G>C	c.(736-738)GAC>CAC	p.D246H	NDUFB9_uc011lim.1_Intron|MTSS1_uc011lin.1_5'UTR|MTSS1_uc011lio.1_Missense_Mutation_p.D136H|MTSS1_uc003yri.2_Missense_Mutation_p.D46H|MTSS1_uc003yrj.2_Missense_Mutation_p.D246H|MTSS1_uc003yrl.2_Missense_Mutation_p.D250H	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	246	IMD.|Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CCTTTCAAGTCCAGAATCACC	0.527		NA											55	50					0	0	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996592	143996592	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:143996592C>G	uc003yxk.1	-	3	468	c.465G>C	c.(463-465)CAG>CAC	p.Q155H		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	155					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGAGGAACCTCTGCACGGCCT	0.637		NA							Familial_Hyperaldosteronism_type_I				10	59					0	0	0	0
TMEM38B	55151	broad.mit.edu	37	9	108483954	108483954	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr9:108483954T>A	uc004bcu.1	+	3	523	c.406T>A	c.(406-408)TAT>AAT	p.Y136N	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	136	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						TGCTAATAGCTATTACAAAAA	0.388		NA											75	44					0	0	0	0
CACNA1B	774	broad.mit.edu	37	9	140919617	140919617	+	Silent	SNP	C	C	T	rs147270326	by1000genomes	TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr9:140919617C>T	uc004cog.2	+	20	3424	c.3279C>T	c.(3277-3279)GTC>GTT	p.V1093V	CACNA1B_uc011mfd.1_Silent_p.V623V|CACNA1B_uc004coi.2_Silent_p.V303V	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1093	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AAGCCACGGTCGTTCCCAGTG	0.617		NA											28	13					0	0	0	0
ASB9	140462	broad.mit.edu	37	X	15268558	15268558	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:15268558C>A	uc004cwl.2	-	5	809	c.562G>T	c.(562-564)GAG>TAG	p.E188*	ASB9_uc004cwk.2_Nonsense_Mutation_p.E188*|ASB9_uc004cwm.2_Nonsense_Mutation_p.E178*|ASB9_uc010ner.2_Nonsense_Mutation_p.E188*|ASB9_uc004cwn.2_Nonsense_Mutation_p.E159*	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	188	ANK 5.				intracellular signal transduction						0	Hepatocellular(33;0.183)					TTACCTGACTCCAGAAGCTTC	0.348		NA											37	56					4.14e-20	4.93e-20	1	0
SLC7A3	84889	broad.mit.edu	37	X	70149727	70149728	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:70149727_70149728CC>TA	uc004dyn.2	-	2	278_279	c.120_121GG>TA	c.(118-123)CTGGGT>CTTAGT	p.G41S	SLC7A3_uc004dyo.2_Missense_Mutation_p.G41S	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	41	Helical; Name=1; (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CTGCCCACACCCAGGGCCACTA	0.559		NA											7	28					0	0	0	0
STAG2	10735	broad.mit.edu	37	X	123164834	123164834	+	Silent	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:123164834C>T	uc004etz.3	+	4	486	c.147C>T	c.(145-147)GGC>GGT	p.G49G	STAG2_uc004eua.2_Silent_p.G49G|STAG2_uc004eub.2_Silent_p.G49G|STAG2_uc004euc.2_Silent_p.G49G|STAG2_uc004eud.2_Silent_p.G49G|STAG2_uc004eue.2_Silent_p.G49G	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	49					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GCAAAAAGGGCCCAGCAGAAA	0.418		NA											76	31					0	0	0	0
IRAK1	3654	broad.mit.edu	37	X	153278545	153278545	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:153278545C>T	uc004fjs.1	-	12	1958	c.1879G>A	c.(1879-1881)GGA>AGA	p.G627R	IRAK1_uc004fjr.1_Missense_Mutation_p.G597R|IRAK1_uc004fjt.1_Missense_Mutation_p.G548R|IRAK1_uc010nur.2_Intron	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	627					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTCGATTCTCCTGCCGTGTCC	0.687		NA											16	15					0	0	0	0
C11orf41	25758	broad.mit.edu	37	11	33565011	33565017	+	Frame_Shift_Del	DEL	CACCCAG	CACCCAG	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:33565011_33565017delCACCCAG	uc001mup.3	+	1	1135_1141	c.1011_1017delCACCCAG	c.(1009-1017)GCCACCCAGfs	p.A337fs	C11orf41_uc001mun.1_Frame_Shift_Del_p.A337fs	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	337_339						integral to membrane				ovary(2)	2						CCATACAAGCCACCCAGACTGTTTTCC	0.517		NA									OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	307	---	---	---	---	NA	NA	NA	NA
STK16	8576	broad.mit.edu	37	2	220113249	220113250	+	In_Frame_Ins	INS	-	-	CAG			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:220113249_220113250insCAG	uc002vko.2	+	8	1043_1044	c.886_887insCAG	c.(886-888)CCA>CCAGCA	p.297_298insA	STK16_uc002vks.2_In_Frame_Ins_p.179_180insA|STK16_uc002vkp.2_In_Frame_Ins_p.297_298insA|STK16_uc002vkr.2_In_Frame_Ins_p.230_231insA|STK16_uc002vkq.2_In_Frame_Ins_p.342_343insA	NM_001008910	NP_001008910	O75716	STK16_HUMAN	serine/threonine kinase 16	297_298					protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTTCAGCCCCCAGCTCCTGGC	0.55		NA											22	162	---	---	---	---	NA	NA	NA	NA
POLR3H	171568	broad.mit.edu	37	22	41928719	41928719	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr22:41928719delA	uc003baf.2	-	4	299	c.239delT	c.(238-240)TTCfs	p.F80fs	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Frame_Shift_Del_p.F80fs|POLR3H_uc003bai.2_Intron	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	80					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						CTCATCTAGGAATGGATGAAA	0.547		NA									OREG0026590	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	73	---	---	---	---	NA	NA	NA	NA
TREX1	11277	broad.mit.edu	37	3	48507992	48507993	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:48507992_48507993delCT	uc003ctj.2	+	2	1360_1361	c.103_104delCT	c.(103-105)CTGfs	p.L35fs	TREX1_uc010hjy.2_Intron|TREX1_uc003ctk.2_Intron|TREX1_uc010hjz.2_Intron|TREX1_uc010hka.2_Frame_Shift_Del_p.L35fs	NM_033629	NP_338599	Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1 isoform b	35					cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GATCTTAACACTGGGCACTCAC	0.658		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					101	153	---	---	---	---	NA	NA	NA	NA
C6orf182	285753	broad.mit.edu	37	6	109484156	109484158	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:109484156_109484158delATC	uc010kdk.2	+	13	1943_1945	c.1366_1368delATC	c.(1366-1368)ATCdel	p.I456del	C6orf182_uc003psx.3_3'UTR|C6orf182_uc010kdl.2_In_Frame_Del_p.I456del|C6orf182_uc003psy.3_In_Frame_Del_p.I456del	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	456						microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		AAGAGATGATATCATGTGGGAAC	0.335		NA											20	58	---	---	---	---	NA	NA	NA	NA
OGDH	4967	broad.mit.edu	37	7	44715617	44715617	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:44715617delA	uc003tln.2	+	9	1184	c.1075delA	c.(1075-1077)AATfs	p.N359fs	OGDH_uc003tlm.2_Frame_Shift_Del_p.N359fs|OGDH_uc011kbx.1_Frame_Shift_Del_p.N355fs|OGDH_uc011kby.1_Frame_Shift_Del_p.N209fs|OGDH_uc003tlp.2_Frame_Shift_Del_p.N370fs|OGDH_uc011kbz.1_Frame_Shift_Del_p.N154fs|OGDH_uc003tlo.1_Frame_Shift_Del_p.N192fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	359					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	CCGCAGGATCAATCGTGTCAC	0.562		NA											78	216	---	---	---	---	NA	NA	NA	NA
NOTCH1	4851	broad.mit.edu	37	9	139411734	139411740	+	Frame_Shift_Del	DEL	CTCGCAC	CTCGCAC	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr9:139411734_139411740delCTCGCAC	uc004chz.2	-	9	1539_1545	c.1539_1545delGTGCGAG	c.(1537-1545)CAGTGCGAGfs	p.Q513fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	513_515	Extracellular (Potential).|EGF-like 13; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGTGGGGCACTCGCACTGGAACTCAT	0.691		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			12	12	---	---	---	---	NA	NA	NA	NA
GUCY2F	2986	broad.mit.edu	37	X	108619355	108619355	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:108619355delT	uc004eod.3	-	18	3468	c.3192delA	c.(3190-3192)AAAfs	p.K1064fs	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1064	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCATGAAGCCTTTTTTCCCAA	0.418		NA											7	359	---	---	---	---	NA	NA	NA	NA