Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
KIF1B	23095	broad.mit.edu	37	1	10386207	10386207	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:10386207C>T	uc001aqx.3	+	27	2916	c.2714C>T	c.(2713-2715)GCC>GTC	p.A905V	KIF1B_uc001aqw.3_Missense_Mutation_p.A859V|KIF1B_uc001aqy.2_Missense_Mutation_p.A879V|KIF1B_uc001aqz.2_Missense_Mutation_p.A905V|KIF1B_uc001ara.2_Missense_Mutation_p.A865V|KIF1B_uc001arb.2_Missense_Mutation_p.A891V	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	905					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GAGCGCCTTGCCGACCGCACA	0.542		NA											5	244					0	0	0	0
CELA3B	23436	broad.mit.edu	37	1	22304901	22304901	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:22304901G>T	uc001bfk.2	+	2	198	c.83G>T	c.(82-84)CGC>CTC	p.R28L	CELA3B_uc009vqf.2_Missense_Mutation_p.R27L	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	28					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CCTTCCAGCCGCGTTGTCAAT	0.582		NA											42	23					6.27e-28	8.63e-28	1	0
CELA3B	23436	broad.mit.edu	37	1	22307604	22307604	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:22307604C>A	uc001bfk.2	+	4	416	c.301C>A	c.(301-303)CCC>ACC	p.P101T	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	101	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GCAGGTGATCCCCATCAACTC	0.632		NA									OREG0013210	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	28					2.17e-29	3e-29	1	0
KIAA1522	57648	broad.mit.edu	37	1	33237516	33237516	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:33237516G>A	uc001bvv.2	+	6	2695	c.2559G>A	c.(2557-2559)CTG>CTA	p.L853L	KIAA1522_uc001bvu.1_Silent_p.L912L|KIAA1522_uc010ohm.1_Silent_p.L864L|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	853	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGAAACCACTGCGAAGGGCCC	0.716		NA											12	17					0	0	0	0
ZMYM1	79830	broad.mit.edu	37	1	35578906	35578906	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:35578906G>A	uc001bym.2	+	11	1623	c.1475G>A	c.(1474-1476)AGA>AAA	p.R492K	ZMYM1_uc001byn.2_Missense_Mutation_p.R492K|ZMYM1_uc010ohu.1_Missense_Mutation_p.R473K|ZMYM1_uc001byo.2_Missense_Mutation_p.R132K|ZMYM1_uc009vut.2_Missense_Mutation_p.R417K	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	492	TTF-type.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCTGTGGAAGAGAGTCATTT	0.348		NA											57	107					0	0	0	0
ERMAP	114625	broad.mit.edu	37	1	43308691	43308691	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:43308691A>G	uc001cic.1	+	12	1486	c.1216A>G	c.(1216-1218)ACA>GCA	p.T406A	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.T406A|ERMAP_uc001cif.1_Missense_Mutation_p.T316A	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	406	Cytoplasmic (Potential).|B30.2/SPRY.		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGAAAAAACACAGCACCTCT	0.463		NA											62	115					0	0	0	0
HECTD3	79654	broad.mit.edu	37	1	45472642	45472642	+	Silent	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:45472642T>A	uc009vxk.2	-	12	1700	c.1602A>T	c.(1600-1602)GCA>GCT	p.A534A	HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Silent_p.A144A|HECTD3_uc010olh.1_Silent_p.A250A	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	534	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGATGCCTTCTGCAATAAATT	0.507		NA											34	53					0	0	0	0
CYP4A11	1579	broad.mit.edu	37	1	47407066	47407066	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:47407066C>A	uc001cqp.3	-	1	91	c.40G>T	c.(40-42)GAT>TAT	p.D14Y	CYP4A11_uc001cqq.2_Missense_Mutation_p.D14Y|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	14					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CCAGAGACATCACCCAGGAGT	0.597		NA											68	123					2.43e-22	3.2e-22	1	0
CYP4A22	284541	broad.mit.edu	37	1	47609432	47609432	+	Splice_Site	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:47609432A>C	uc001cqv.1	+	6	687	c.636_splice	c.e6-2	p.R212_splice	CYP4A22_uc009vyo.2_Splice_Site_p.R212_splice|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,							endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ACTCTCCCTCAGGAATTCTCA	0.512		NA											52	73					0	0	0	0
ELAVL4	1996	broad.mit.edu	37	1	50659494	50659494	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:50659494G>A	uc001csb.2	+	4	680	c.412G>A	c.(412-414)GGC>AGC	p.G138S	ELAVL4_uc001cry.3_Missense_Mutation_p.G141S|ELAVL4_uc001crz.3_Missense_Mutation_p.G138S|ELAVL4_uc001csa.3_Missense_Mutation_p.G155S|ELAVL4_uc001csc.3_Missense_Mutation_p.G138S|ELAVL4_uc009vyu.2_Missense_Mutation_p.G143S|ELAVL4_uc010omz.1_Missense_Mutation_p.G143S	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	138	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						CTATGTTAGCGGCCTTCCCAA	0.488		NA											105	140					0	0	0	0
C8B	732	broad.mit.edu	37	1	57425761	57425761	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:57425761T>A	uc001cyp.2	-	2	248	c.181A>T	c.(181-183)ATG>TTG	p.M61L	C8B_uc010oon.1_5'UTR|C8B_uc010ooo.1_Missense_Mutation_p.M9L	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	61					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TCAATGGGCATCAGGGTAACA	0.488		NA											58	83					0	0	0	0
PGM1	5236	broad.mit.edu	37	1	64117492	64117492	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:64117492A>T	uc001dbh.2	+	9	1646	c.1433A>T	c.(1432-1434)GAC>GTC	p.D478V	PGM1_uc010ooy.1_Missense_Mutation_p.D281V|PGM1_uc010ooz.1_Missense_Mutation_p.D496V	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	478					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GAATACAGCGACCCAGTGGAT	0.463		NA											21	53					0	0	0	0
SGIP1	84251	broad.mit.edu	37	1	67155877	67155877	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:67155877G>T	uc001dcr.2	+	17	1665	c.1448G>T	c.(1447-1449)AGA>ATA	p.R483I	SGIP1_uc010opd.1_Missense_Mutation_p.R83I|SGIP1_uc001dcs.2_Missense_Mutation_p.R83I|SGIP1_uc001dct.2_Missense_Mutation_p.R83I|SGIP1_uc009wat.2_Missense_Mutation_p.R277I	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	483	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TTACAGTCCAGACCTTTTAGC	0.443		NA											87	167					1.29e-55	1.95e-55	1	0
C1orf173	127254	broad.mit.edu	37	1	75037355	75037355	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:75037355C>A	uc001dgg.2	-	14	4258	c.4039G>T	c.(4039-4041)GGT>TGT	p.G1347C		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1347	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCCGTTTCACCACCTCCGTGT	0.537		NA											44	66					2.14e-21	2.78e-21	1	0
LPHN2	23266	broad.mit.edu	37	1	82409022	82409022	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:82409022A>G	uc001dit.3	+	6	948	c.767A>G	c.(766-768)TAC>TGC	p.Y256C	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.Y256C|LPHN2_uc001div.2_Missense_Mutation_p.Y256C|LPHN2_uc009wcd.2_Missense_Mutation_p.Y256C	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	256	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACCTCACCATACAGATGGGGA	0.393		NA											60	88					0	0	0	0
LPHN2	23266	broad.mit.edu	37	1	82445578	82445578	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:82445578C>A	uc001dit.3	+	17	3177	c.2996C>A	c.(2995-2997)ACA>AAA	p.T999K	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.T999K|LPHN2_uc001div.2_Missense_Mutation_p.T999K|LPHN2_uc009wcd.2_Missense_Mutation_p.T999K|LPHN2_uc001diw.2_Missense_Mutation_p.T583K|LPHN2_uc009wce.1_Missense_Mutation_p.T85K	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1012	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTGGTGATCACATTGTGCAAA	0.299		NA											31	62					2.05e-20	2.64e-20	1	0
LPPR5	163404	broad.mit.edu	37	1	99387542	99387542	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:99387542A>C	uc001dsb.2	-	4	916	c.694T>G	c.(694-696)TGT>GGT	p.C232G	LPPR5_uc001dsc.2_Missense_Mutation_p.C232G	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	232	Helical; (Potential).					integral to membrane	hydrolase activity				0						AATGCCAAACACATTAAGCCC	0.378		NA											67	77					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103496734	103496734	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:103496734T>C	uc001dul.2	-	5	1036	c.718A>G	c.(718-720)AGT>GGT	p.S240G	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.S240G|COL11A1_uc001dun.2_Missense_Mutation_p.S240G|COL11A1_uc009weh.2_Missense_Mutation_p.S240G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	240	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGTCTGGACTATAATGCTCA	0.448		NA											22	38					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103496752	103496752	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:103496752C>T	uc001dul.2	-	5	1018	c.700G>A	c.(700-702)GAC>AAC	p.D234N	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.D234N|COL11A1_uc001dun.2_Missense_Mutation_p.D234N|COL11A1_uc009weh.2_Missense_Mutation_p.D234N	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	234	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCACAGTAGTCATATGCTGCC	0.443		NA											21	41					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103548502	103548502	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:103548502G>A	uc001dul.2	-	2	451	c.133C>T	c.(133-135)CTA>TTA	p.L45L	COL11A1_uc001dum.2_Silent_p.L45L|COL11A1_uc001dun.2_Silent_p.L45L|COL11A1_uc009weh.2_Silent_p.L45L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	45	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGAAAATCTAGTGCTTTTAGT	0.333		NA											51	87					0	0	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110032945	110032945	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:110032945G>A	uc001dxr.2	+	9	1304	c.1289G>A	c.(1288-1290)CGC>CAC	p.R430H	ATXN7L2_uc001dxs.2_Missense_Mutation_p.R57H|ATXN7L2_uc001dxt.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	430										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GTGTTTAGCCGCCGGCTGGAC	0.577		NA									OREG0013635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	72					0	0	0	0
LRIG2	9860	broad.mit.edu	37	1	113652911	113652911	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:113652911G>T	uc001edf.1	+	13	1723	c.1525G>T	c.(1525-1527)GCT>TCT	p.A509S	LRIG2_uc009wgn.1_Missense_Mutation_p.A406S	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	509	Ig-like C2-type 1.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		AACCATAATTGCTCTAAGAGG	0.428		NA											63	110					3.13e-38	4.52e-38	1	0
AMPD1	270	broad.mit.edu	37	1	115231345	115231345	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:115231345G>T	uc001efe.1	-	3	136	c.52C>A	c.(52-54)CGC>AGC	p.R18S	AMPD1_uc001eff.1_Missense_Mutation_p.R14S	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	18					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GCAAAGTTGCGCATTGCATCA	0.423		NA											68	138					4.66e-34	6.62e-34	1	0
FLG	2312	broad.mit.edu	37	1	152280766	152280766	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:152280766G>T	uc001ezu.1	-	3	6632	c.6596C>A	c.(6595-6597)TCA>TAA	p.S2199*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2199	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCATCTCCTGATTGTTCCTT	0.542		NA							Ichthyosis				298	419					1.64e-181	2.53e-181	1	0
OR10K2	391107	broad.mit.edu	37	1	158389859	158389859	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:158389859G>A	uc010pii.1	-	1	798	c.798C>T	c.(796-798)TAC>TAT	p.Y266Y		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GGCTTGAGGAGTAGTTGGACT	0.398		NA											133	20					0	0	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018684	161018684	+	Silent	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:161018684A>G	uc001fxl.2	-	12	2473	c.2127T>C	c.(2125-2127)AGT>AGC	p.S709S	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Intron|ARHGAP30_uc001fxm.2_Silent_p.S555S|ARHGAP30_uc009wtx.2_Silent_p.S382S	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	709	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TCTCTTCCCTACTCCCTTCTC	0.527		NA											263	354					0	0	0	0
GPA33	10223	broad.mit.edu	37	1	167024302	167024302	+	Silent	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:167024302A>T	uc001gea.1	-	6	1082	c.738T>A	c.(736-738)GTT>GTA	p.V246V		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	246	Helical; (Potential).					integral to plasma membrane	receptor activity				0						TGAGGGCTGCAACCACGCCCA	0.577		NA											91	16					0	0	0	0
CD247	919	broad.mit.edu	37	1	167408592	167408592	+	Nonsense_Mutation	SNP	G	G	A	rs74315290		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:167408592G>A	uc001gei.3	-	3	353	c.208C>T	c.(208-210)CAG>TAG	p.Q70*	CD247_uc001gej.3_Nonsense_Mutation_p.Q70*|CD247_uc001gek.2_Nonsense_Mutation_p.Q70*	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	70	Cytoplasmic (Potential).|ITAM 1.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TTATAGAGCTGGTTCTGGCCC	0.592		NA											60	120					0	0	0	0
SELP	6403	broad.mit.edu	37	1	169580850	169580850	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:169580850C>G	uc001ggi.3	-	7	1092	c.1027G>C	c.(1027-1029)GCT>CCT	p.A343P	SELP_uc001ggh.2_Missense_Mutation_p.A178P|SELP_uc009wvr.2_Missense_Mutation_p.A343P	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	343	Sushi 3.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TAGGCAAAAGCAGTGAGCGGA	0.532		NA											130	21					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196285139	196285139	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:196285139C>G	uc001gtd.1	-	21	2426	c.2366G>C	c.(2365-2367)AGG>ACG	p.R789T	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R715T|KCNT2_uc001gtf.1_Missense_Mutation_p.R765T|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.R765T|KCNT2_uc001gth.1_Missense_Mutation_p.R286T	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	789	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CACTCCACACCTGAGTAAGTC	0.393		NA											29	7					0	0	0	0
F13B	2165	broad.mit.edu	37	1	197031010	197031010	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:197031010C>A	uc001gtt.1	-	3	399	c.355G>T	c.(355-357)GCT>TCT	p.A119S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	119	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TACCCTGAAGCGCAACCATAA	0.403		NA											46	18					4.44e-20	5.7e-20	1	0
CR1L	1379	broad.mit.edu	37	1	207871016	207871016	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:207871016G>C	uc001hga.3	+	6	1152	c.1031G>C	c.(1030-1032)AGA>ACA	p.R344T	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	344	Sushi 5.					cytoplasm|extracellular region|membrane					0						GCAGCCCCCAGATGTGAAGGT	0.493		NA											286	64					0	0	0	0
CENPF	1063	broad.mit.edu	37	1	214819347	214819347	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:214819347G>A	uc001hkm.2	+	13	6608	c.6434G>A	c.(6433-6435)CGC>CAC	p.R2145H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2241	Potential.|2-1.|2 X 177 AA tandem repeats.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CTGAAAGAACGCGAGCGGGAG	0.468		NA											94	13					0	0	0	0
ESRRG	2104	broad.mit.edu	37	1	216850746	216850746	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:216850746G>A	uc001hkw.1	-	2	310	c.144C>T	c.(142-144)TCC>TCT	p.S48S	ESRRG_uc001hky.1_Silent_p.S25S|ESRRG_uc009xdp.1_Silent_p.S25S|ESRRG_uc001hkz.1_Silent_p.S25S|ESRRG_uc010puc.1_Silent_p.S25S|ESRRG_uc001hla.1_Silent_p.S25S|ESRRG_uc001hlb.1_Silent_p.S25S|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.S25S|ESRRG_uc001hld.1_Silent_p.S25S|ESRRG_uc001hkx.1_Silent_p.S53S|ESRRG_uc009xdo.1_Silent_p.S25S|ESRRG_uc001hle.1_Silent_p.S25S	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	48					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TGTCCGTCAGGGAGGCTGGGC	0.532		NA											81	21					0	0	0	0
C1orf65	164127	broad.mit.edu	37	1	223568029	223568029	+	Silent	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:223568029C>G	uc001hoa.2	+	1	1315	c.1212C>G	c.(1210-1212)GCC>GCG	p.A404A		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	404										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		TGGTGGAAGCCTGTCGCAAGA	0.622		NA											43	6					0	0	0	0
PARP1	142	broad.mit.edu	37	1	226549218	226549218	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:226549218C>T	uc001hqd.3	-	23	3159	c.2988G>A	c.(2986-2988)CAG>CAA	p.Q996Q		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	996	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TCAGATTTACCTGAGCAATAT	0.473		NA						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					50	6					0	0	0	0
COG2	22796	broad.mit.edu	37	1	230827172	230827172	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:230827172G>A	uc001htw.2	+	17	2128	c.1977G>A	c.(1975-1977)AAG>AAA	p.K659K	COG2_uc001htx.2_Silent_p.K658K|COG2_uc010pwc.1_Silent_p.K532K	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	659					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CTGTGAAGAAGATGGAAGAGA	0.463		NA											62	7					0	0	0	0
ARID4B	51742	broad.mit.edu	37	1	235345469	235345469	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:235345469T>G	uc001hwq.2	-	20	3263	c.2765A>C	c.(2764-2766)AAA>ACA	p.K922T	ARID4B_uc001hwr.2_Missense_Mutation_p.K836T|ARID4B_uc001hws.3_Missense_Mutation_p.K836T|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.K603T	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	922					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TTTTCGATCTTTGGCCCTGCT	0.408		NA											191	31					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237670115	237670115	+	Splice_Site	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:237670115G>T	uc001hyl.1	+	23	2838	c.2718_splice	c.e23+1	p.P906_splice		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTATGGTCCGGTATGTAATTT	0.368		NA											15	22					2.62e-11	3.12e-11	1	0
RYR2	6262	broad.mit.edu	37	1	237711878	237711879	+	Nonsense_Mutation	DNP	TG	TG	AT	rs113422365		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:237711878_237711879TG>AT	uc001hyl.1	+	26	3174_3175	c.3054_3055TG>AT	c.(3052-3057)TATGGC>TAATGC	p.1018_1019YG>*C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1018_1019	Cytoplasmic (By similarity).|2.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCTGGACTTATGGCATCCAACA	0.426		NA											42	11					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237778123	237778123	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:237778123C>T	uc001hyl.1	+	37	5815	c.5695C>T	c.(5695-5697)CCA>TCA	p.P1899S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1899	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AATGAAACTGCCAGAGCCAGT	0.468		NA											63	9					0	0	0	0
OPN3	23596	broad.mit.edu	37	1	241761198	241761198	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:241761198C>T	uc001hza.2	-	3	940	c.795G>A	c.(793-795)CTG>CTA	p.L265L	OPN3_uc001hzb.2_RNA|OPN3_uc001hzc.2_RNA	NM_014322	NP_055137	Q9H1Y3	OPN3_HUMAN	opsin 3	265	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity				0	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCCAACAGACCAGGAAGGTGA	0.378		NA											101	23					0	0	0	0
OR2T12	127064	broad.mit.edu	37	1	248458280	248458280	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:248458280A>T	uc010pzj.1	-	1	601	c.601T>A	c.(601-603)TGT>AGT	p.C201S		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTAACACACAGCAGATGTAC	0.542		NA											107	24					0	0	0	0
OR2G6	391211	broad.mit.edu	37	1	248685252	248685252	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:248685252A>T	uc001ien.1	+	1	305	c.305A>T	c.(304-306)TAT>TTT	p.Y102F		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCCAGCTCTATGTGGCCATG	0.537		NA											127	19					0	0	0	0
OR14I1	401994	broad.mit.edu	37	1	248845040	248845040	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:248845040T>A	uc001ieu.1	-	1	566	c.566A>T	c.(565-567)GAG>GTG	p.E189V		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGAAAACCTCACAGGAAAC	0.483		NA											60	14					0	0	0	0
GTPBP4	23560	broad.mit.edu	37	10	1034450	1034450	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:1034450G>T	uc001ift.2	+	1	102	c.31G>T	c.(31-33)GTG>TTG	p.V11L	GTPBP4_uc010qac.1_5'UTR|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_5'UTR|GTPBP4_uc010qae.1_5'Flank	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	11					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GAAAATTACGGTGGTGCCGTC	0.657		NA											20	5					6.45e-10	7.53e-10	1	0
CUBN	8029	broad.mit.edu	37	10	17083215	17083215	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:17083215A>C	uc001ioo.2	-	27	3886	c.3834T>G	c.(3832-3834)TGT>TGG	p.C1278W		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1278	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCACATTCTCACATGCTGGAA	0.338		NA											65	19					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	17142060	17142060	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:17142060G>A	uc001ioo.2	-	14	1761	c.1709C>T	c.(1708-1710)TCT>TTT	p.S570F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	570	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TAAATGTTCAGAATAGAGATG	0.418		NA											105	36					0	0	0	0
GAD2	2572	broad.mit.edu	37	10	26512888	26512888	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:26512888C>A	uc001isp.2	+	5	1096	c.593C>A	c.(592-594)TCA>TAA	p.S198*	GAD2_uc001isq.2_Nonsense_Mutation_p.S198*	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	198					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TGGCTGACATCAACAGCAAAT	0.343		NA											40	13					6.97e-18	8.8e-18	1	0
RBP3	5949	broad.mit.edu	37	10	48388397	48388397	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:48388397G>T	uc001jez.2	-	1	2595	c.2481C>A	c.(2479-2481)CCC>CCA	p.P827P		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	827	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CGGCGACCTGGGGCAAGGTCC	0.612		NA											14	8					7.93e-07	8.83e-07	1	0
C10orf71	118461	broad.mit.edu	37	10	50532657	50532657	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:50532657G>A	uc010qgp.1	+	3	2406	c.2067G>A	c.(2065-2067)CAG>CAA	p.Q689Q		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	689											0						CAGGACTTCAGAACACACATT	0.502		NA											25	11					0	0	0	0
A1CF	29974	broad.mit.edu	37	10	52573752	52573752	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:52573752G>T	uc001jjj.2	-	10	1400	c.1212C>A	c.(1210-1212)TAC>TAA	p.Y404*	A1CF_uc010qhn.1_Nonsense_Mutation_p.Y404*|A1CF_uc001jji.2_Nonsense_Mutation_p.Y396*|A1CF_uc001jjh.2_Nonsense_Mutation_p.Y404*|A1CF_uc010qho.1_Nonsense_Mutation_p.Y412*|A1CF_uc009xov.2_Nonsense_Mutation_p.Y396*	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	404	Required for nuclear localization.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CCAGGCCTGTGTATGCCAAAT	0.483		NA											94	30					2.09e-44	3.08e-44	1	0
PCDH15	65217	broad.mit.edu	37	10	55600188	55600188	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:55600188C>A	uc001jju.1	-	29	4270	c.3875G>T	c.(3874-3876)CGC>CTC	p.R1292L	PCDH15_uc010qhq.1_Missense_Mutation_p.R1297L|PCDH15_uc010qhr.1_Missense_Mutation_p.R1292L|PCDH15_uc010qhs.1_Missense_Mutation_p.R1304L|PCDH15_uc010qht.1_Missense_Mutation_p.R1299L|PCDH15_uc010qhu.1_Missense_Mutation_p.R1292L|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1292L|PCDH15_uc010qhw.1_Missense_Mutation_p.R1255L|PCDH15_uc010qhx.1_Missense_Mutation_p.R1221L|PCDH15_uc010qhy.1_Missense_Mutation_p.R1297L|PCDH15_uc010qhz.1_Missense_Mutation_p.R1292L|PCDH15_uc010qia.1_Missense_Mutation_p.R1270L|PCDH15_uc010qib.1_Missense_Mutation_p.R1270L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1292	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCATGCCGGCGAGCTCCAAT	0.448		NA								HNSCC(58;0.16)			76	15					5.33e-40	7.76e-40	1	0
CTNNA3	29119	broad.mit.edu	37	10	69281617	69281617	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:69281617C>T	uc009xpn.1	-	5	685	c.562G>A	c.(562-564)GCC>ACC	p.A188T	CTNNA3_uc001jmw.2_Missense_Mutation_p.A188T|CTNNA3_uc001jmx.3_Missense_Mutation_p.A188T|CTNNA3_uc009xpo.1_Missense_Mutation_p.A48T|CTNNA3_uc001jna.2_Missense_Mutation_p.A200T	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	188					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CGTTTGAAGGCTAAATAATCC	0.478		NA											43	23					0	0	0	0
CNNM1	26507	broad.mit.edu	37	10	101120594	101120594	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:101120594G>C	uc001kpp.3	+	3	2009	c.1720G>C	c.(1720-1722)GAC>CAC	p.D574H	CNNM1_uc009xwe.2_Missense_Mutation_p.D574H|CNNM1_uc010qpi.1_Missense_Mutation_p.D574H|CNNM1_uc009xwf.2_Missense_Mutation_p.D574H|CNNM1_uc009xwg.2_5'UTR	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	574					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CCCCACAGCTGACAATCGGAA	0.507		NA											137	58					0	0	0	0
ABCC2	1244	broad.mit.edu	37	10	101591439	101591439	+	Silent	SNP	G	G	A	rs139082536	byFrequency	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:101591439G>A	uc001kqf.2	+	22	3094	c.2955G>A	c.(2953-2955)GCG>GCA	p.A985A		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	985	ABC transmembrane type-1 2.|Helical; Name=12; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCATCCTTGCGTTTGTGATGA	0.433		NA											6	181					0	0	0	0
MGEA5	10724	broad.mit.edu	37	10	103558944	103558944	+	Silent	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:103558944A>C	uc001ktv.2	-	9	1907	c.1464T>G	c.(1462-1464)GTT>GTG	p.V488V	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Silent_p.V435V|MGEA5_uc009xws.2_Silent_p.V435V|MGEA5_uc001ktw.2_Silent_p.V488V|MGEA5_uc009xwt.2_Silent_p.V251V	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	488					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TTTTCGCTTCAACAATTTCAC	0.393		NA											204	79					0	0	0	0
NFKB2	4791	broad.mit.edu	37	10	104161253	104161253	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:104161253C>A	uc001kvb.2	+	20	2536	c.2271C>A	c.(2269-2271)CCC>CCA	p.P757P	NFKB2_uc001kva.2_Silent_p.P757P|NFKB2_uc001kvd.2_Silent_p.P757P|NFKB2_uc009xxc.2_Silent_p.P757P	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	757	ANK 7.		Missing (in truncated form p80HT).|Missing (in truncated form LB40).|Missing (in truncated form EB308).		innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		TGGAGCCACCCCTGACCCCGC	0.597		NA	T	IGH@	B-NHL								32	21					2.76e-19	3.52e-19	1	0
SORCS1	114815	broad.mit.edu	37	10	108427560	108427560	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:108427560G>T	uc001kym.2	-	17	2198	c.2190C>A	c.(2188-2190)TGC>TGA	p.C730*	SORCS1_uc001kyl.2_Nonsense_Mutation_p.C730*|SORCS1_uc009xxs.2_Nonsense_Mutation_p.C730*|SORCS1_uc001kyn.1_Nonsense_Mutation_p.C730*|SORCS1_uc001kyo.2_Nonsense_Mutation_p.C730*	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	730	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AACCATAGTCGCTGTTAGGAA	0.453		NA											21	4					2.32e-17	2.92e-17	1	0
TCF7L2	6934	broad.mit.edu	37	10	114910775	114910775	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:114910775C>T	uc001lae.3	+	9	1401	c.894C>T	c.(892-894)GTC>GTT	p.V298V	TCF7L2_uc001lac.3_Silent_p.V275V|TCF7L2_uc010qrk.1_Silent_p.V275V|TCF7L2_uc010qrl.1_Silent_p.V275V|TCF7L2_uc010qrm.1_Silent_p.V298V|TCF7L2_uc010qrn.1_Silent_p.V241V|TCF7L2_uc001lad.3_Silent_p.V271V|TCF7L2_uc001lag.3_Silent_p.V322V|TCF7L2_uc001laf.3_Silent_p.V275V|TCF7L2_uc010qro.1_Silent_p.V275V|TCF7L2_uc001lah.2_Silent_p.V280V|TCF7L2_uc010qrp.1_Silent_p.V275V|TCF7L2_uc010qrq.1_Silent_p.V271V|TCF7L2_uc010qrr.1_Silent_p.V213V|TCF7L2_uc010qrs.1_Silent_p.V169V|TCF7L2_uc010qrt.1_Silent_p.V169V|TCF7L2_uc010qru.1_Silent_p.V197V|TCF7L2_uc010qrv.1_Silent_p.V115V|TCF7L2_uc010qrw.1_Silent_p.V2V|TCF7L2_uc010qrx.1_Silent_p.V155V	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	298	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CCCATATGGTCCCACCACATC	0.473		NA											59	19					0	0	0	0
ATRNL1	26033	broad.mit.edu	37	10	117045743	117045743	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:117045743G>T	uc001lcg.2	+	15	2637	c.2251G>T	c.(2251-2253)GGA>TGA	p.G751*		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	751	PSI 3.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTGTGGAGAAGGATGGAGTCA	0.313		NA											35	14					1.16e-17	1.45e-17	1	0
FAM196A	642938	broad.mit.edu	37	10	128974408	128974408	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:128974408G>T	uc001lju.1	-	1	293	c.252C>A	c.(250-252)TAC>TAA	p.Y84*	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Nonsense_Mutation_p.Y84*|FAM196A_uc001ljv.1_Nonsense_Mutation_p.Y84*|FAM196A_uc009yap.1_Nonsense_Mutation_p.Y84*	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	84										ovary(2)	2						TGTATTTGCGGTAGGCTGCTC	0.607		NA											68	22					1.56e-33	2.21e-33	1	0
FRG2B	441581	broad.mit.edu	37	10	135438990	135438990	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:135438990C>T	uc010qvg.1	-	4	503	c.450G>A	c.(448-450)AGG>AGA	p.R150R		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	150						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CAGTGCAAGCCCTGGAACGTC	0.527		NA											11	178					0	0	0	0
OR51F1	256892	broad.mit.edu	37	11	4790409	4790409	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:4790409C>A	uc010qyl.1	-	1	739	c.739G>T	c.(739-741)GTG>TTG	p.V247L		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	247						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACTGCTCCCACATGGGAGACA	0.488		NA											49	23					4.11e-27	5.62e-27	1	0
OR52B6	340980	broad.mit.edu	37	11	5602862	5602862	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:5602862C>A	uc010qzi.1	+	1	756	c.756C>A	c.(754-756)GCC>GCA	p.A252A	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	252	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCAAGATGCCCGCTCCAAGG	0.507		NA											146	50					2.73e-46	4.05e-46	1	0
DNHD1	144132	broad.mit.edu	37	11	6592373	6592373	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:6592373G>A	uc001mdw.3	+	42	14195	c.13631G>A	c.(13630-13632)GGT>GAT	p.G4544D	DNHD1_uc001mea.3_Missense_Mutation_p.G813D|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.G812D|DNHD1_uc010rao.1_Missense_Mutation_p.G802D|DNHD1_uc009yfg.2_Missense_Mutation_p.G169D	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4544					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCGCCGGCCGGTCCGCAGCCG	0.706		NA											12	3					0	0	0	0
NLRP10	338322	broad.mit.edu	37	11	7982797	7982797	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:7982797T>C	uc001mfv.1	-	2	379	c.362A>G	c.(361-363)TAC>TGC	p.Y121C		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	121							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACCTGGTTGTATCTGCCATT	0.557		NA											50	31					0	0	0	0
FAR1	84188	broad.mit.edu	37	11	13716315	13716315	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:13716315G>A	uc001mld.2	+	2	158	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FAR1_uc009ygp.2_Missense_Mutation_p.M1I	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	1					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						GGATCAAAATGGTTTCAATCC	0.373		NA											42	21					0	0	0	0
ABTB2	25841	broad.mit.edu	37	11	34219030	34219030	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:34219030C>T	uc001mvl.1	-	3	758	c.528G>A	c.(526-528)CCG>CCA	p.P176P		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	176							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				GGCTGGCACCCGGGCACAGGG	0.672		NA											23	11					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136241	40136241	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:40136241C>A	uc001mxa.1	-	2	3566	c.1602G>T	c.(1600-1602)GTG>GTT	p.V534V	LRRC4C_uc001mxc.1_Silent_p.V530V|LRRC4C_uc001mxd.1_Silent_p.V530V|LRRC4C_uc001mxb.1_Silent_p.V530V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	534	Helical; (Potential).				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTGTGATGGCCACAAAACACC	0.463		NA											61	16					1.75e-23	2.33e-23	1	0
PHF21A	51317	broad.mit.edu	37	11	45970965	45970965	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:45970965G>A	uc001ncc.3	-	12	1836	c.1212C>T	c.(1210-1212)GTC>GTT	p.V404V	PHF21A_uc001ncb.3_Silent_p.V405V|PHF21A_uc009ykx.2_Silent_p.V405V|PHF21A_uc001nce.2_Silent_p.V405V|PHF21A_uc001nca.1_Silent_p.V140V	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	404					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTGGCTCAAAGACTGCTCCAC	0.458		NA											103	540					0	0	0	0
OR4C3	256144	broad.mit.edu	37	11	48347133	48347133	+	Missense_Mutation	SNP	G	G	T	rs139158085		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:48347133G>T	uc010rhv.1	+	1	641	c.641G>T	c.(640-642)TGC>TTC	p.C214F		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAAGTTGCCTGCACCAATACG	0.502		NA											60	91					2.45e-32	3.44e-32	1	0
FOLH1	2346	broad.mit.edu	37	11	49197499	49197499	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:49197499C>A	uc001ngy.2	-	8	1192	c.931G>T	c.(931-933)GGC>TGC	p.G311C	FOLH1_uc001ngz.2_Missense_Mutation_p.G311C|FOLH1_uc009yly.2_Missense_Mutation_p.G296C|FOLH1_uc009ylz.2_Missense_Mutation_p.G296C|FOLH1_uc009yma.2_Missense_Mutation_p.G3C	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	311	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GGTGCTGAGCCACCCATTTTT	0.393		NA											62	88					8.53e-23	1.13e-22	1	0
FOLH1	2346	broad.mit.edu	37	11	49207359	49207359	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:49207359C>G	uc001ngy.2	-	6	949	c.688G>C	c.(688-690)GAC>CAC	p.D230H	FOLH1_uc001ngz.2_Missense_Mutation_p.D230H|FOLH1_uc009yly.2_Missense_Mutation_p.D215H|FOLH1_uc009ylz.2_Missense_Mutation_p.D215H|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	230	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TCAGCAGGGTCGGAGTAGAGA	0.458		NA											28	53					0	0	0	0
OR8K5	219453	broad.mit.edu	37	11	55927730	55927730	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:55927730C>T	uc010rja.1	-	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATCTGCAGCTCAGGCCGCCTT	0.453		NA											75	120					0	0	0	0
OR5J2	282775	broad.mit.edu	37	11	55944604	55944604	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:55944604C>T	uc010rjb.1	+	1	511	c.511C>T	c.(511-513)CTA>TTA	p.L171L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CTTTTGTAGGCTAAATGCTGT	0.438		NA											73	114					0	0	0	0
OR5M8	219484	broad.mit.edu	37	11	56258412	56258412	+	Silent	SNP	C	C	A	rs147351186		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:56258412C>A	uc001nix.1	-	1	435	c.435G>T	c.(433-435)ACG>ACT	p.T145T		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CATAAGGCACCGTGATGAGGA	0.517		NA											43	83					6.53e-18	8.25e-18	1	0
OR5M10	390167	broad.mit.edu	37	11	56344286	56344286	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:56344286C>T	uc001niz.1	-	1	912	c.912G>A	c.(910-912)ATG>ATA	p.M304I		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCCCCTAATCATTTGTTGTA	0.373		NA											159	217					0	0	0	0
PRG2	5553	broad.mit.edu	37	11	57156719	57156719	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:57156719G>T	uc001njz.2	-	2	157	c.130C>A	c.(130-132)CAG>AAG	p.Q44K	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.Q44K|PRG2_uc001nkb.2_Missense_Mutation_p.Q44K|PRG2_uc001nkd.2_Missense_Mutation_p.Q44K|PRG2_uc001nkc.2_Missense_Mutation_p.Q44K|PRG2_uc001nke.2_Missense_Mutation_p.Q324K	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	44					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	TCCATCTCCTGCTCTGGTGTC	0.562		NA											74	86					4.61e-44	6.8e-44	1	0
CTNND1	1500	broad.mit.edu	37	11	57569636	57569636	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:57569636C>A	uc001nmc.3	+	7	1959	c.1388C>A	c.(1387-1389)GCT>GAT	p.A463D	CTNND1_uc001nlh.1_Missense_Mutation_p.A463D|CTNND1_uc001nlu.3_Missense_Mutation_p.A362D|CTNND1_uc001nlt.3_Missense_Mutation_p.A362D|CTNND1_uc001nls.3_Missense_Mutation_p.A362D|CTNND1_uc001nlw.3_Missense_Mutation_p.A362D|CTNND1_uc001nmf.3_Missense_Mutation_p.A463D|CTNND1_uc001nmd.3_Missense_Mutation_p.A409D|CTNND1_uc001nlk.3_Missense_Mutation_p.A409D|CTNND1_uc001nme.3_Missense_Mutation_p.A463D|CTNND1_uc001nll.3_Missense_Mutation_p.A409D|CTNND1_uc001nmg.3_Missense_Mutation_p.A409D|CTNND1_uc001nlj.3_Missense_Mutation_p.A409D|CTNND1_uc001nlr.3_Missense_Mutation_p.A409D|CTNND1_uc001nlp.3_Missense_Mutation_p.A409D|CTNND1_uc001nlx.3_Missense_Mutation_p.A140D|CTNND1_uc001nlz.3_Missense_Mutation_p.A140D|CTNND1_uc009ymn.2_Missense_Mutation_p.A140D|CTNND1_uc001nlm.3_Missense_Mutation_p.A463D|CTNND1_uc001nly.3_Missense_Mutation_p.A140D|CTNND1_uc001nmb.3_Missense_Mutation_p.A140D|CTNND1_uc001nma.3_Missense_Mutation_p.A140D|CTNND1_uc001nmi.3_Missense_Mutation_p.A362D|CTNND1_uc001nmh.3_Missense_Mutation_p.A463D|CTNND1_uc001nlq.3_Missense_Mutation_p.A362D|CTNND1_uc001nln.3_Missense_Mutation_p.A463D|CTNND1_uc001nli.3_Missense_Mutation_p.A463D|CTNND1_uc001nlo.3_Missense_Mutation_p.A362D|CTNND1_uc001nlv.3_Missense_Mutation_p.A362D	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	463	ARM 3.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CTTCGAAAGGCTCGTGATATG	0.443		NA											160	294					2.83e-50	4.24e-50	1	0
OR5AN1	390195	broad.mit.edu	37	11	59132216	59132216	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:59132216T>C	uc010rks.1	+	1	285	c.285T>C	c.(283-285)TTT>TTC	p.F95F		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTATCACTTTTGTTGGTTGTA	0.423		NA											158	229					0	0	0	0
OR5A2	219981	broad.mit.edu	37	11	59189575	59189576	+	Missense_Mutation	DNP	GG	GG	TT	rs150394868		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:59189575_59189576GG>TT	uc010rkt.1	-	1	851_852	c.851_852CC>AA	c.(850-852)CCC>CAA	p.P284Q		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATTCACCACGGGGATCACCAA	0.475		NA											55	66					0	0	0	0
SLC15A3	51296	broad.mit.edu	37	11	60718768	60718768	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:60718768G>A	uc001nqn.2	-	1	490	c.256C>T	c.(256-258)CTG>TTG	p.L86L	SLC15A3_uc001nqo.2_Silent_p.L86L	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	solute carrier family 15, member 3	86	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0						ACGGGCGCCAGCAGGTAGGAG	0.716		NA											4	4					0	0	0	0
SCGB2A1	4246	broad.mit.edu	37	11	61977990	61977990	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:61977990C>T	uc001nta.2	+	2	225	c.161C>T	c.(160-162)GCC>GTC	p.A54V		NM_002407	NP_002398	O75556	SG2A1_HUMAN	secretoglobin, family 2A, member 1 precursor	54						extracellular region	androgen binding				0						GACAGTGATGCCGCTGCAGAG	0.428		NA											5	250					0	0	0	0
POLR2G	5436	broad.mit.edu	37	11	62533149	62533149	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:62533149G>T	uc001nva.2	+	6	534	c.424G>T	c.(424-426)GAG>TAG	p.E142*	POLR2G_uc001nvb.2_RNA	NM_002696	NP_002687	P62487	RPB7_HUMAN	DNA directed RNA polymerase II polypeptide G	142					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding				0						GCAGGACGATGAGATCCGCTT	0.468		NA											67	100					3.41e-29	4.72e-29	1	0
ATG2A	23130	broad.mit.edu	37	11	64668018	64668018	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:64668018T>C	uc001obx.2	-	31	4527	c.4412A>G	c.(4411-4413)CAG>CGG	p.Q1471R	ATG2A_uc001obw.2_Missense_Mutation_p.Q236R	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1471							protein binding			ovary(1)|central_nervous_system(1)	2						GCTGCCCCCCTGCGTGCGCCA	0.637		NA											69	102					0	0	0	0
DKFZp761E198	91056	broad.mit.edu	37	11	65546371	65546371	+	Silent	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:65546371C>G	uc001ofo.3	-	1	1452	c.1422G>C	c.(1420-1422)CCG>CCC	p.P474P		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	474							protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		CATCCCTGCCCGGCCTGGACA	0.607		NA											14	14					0	0	0	0
RIN1	9610	broad.mit.edu	37	11	66103108	66103108	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:66103108T>A	uc001ohn.1	-	4	555	c.428A>T	c.(427-429)CAG>CTG	p.Q143L	RIN1_uc010roy.1_5'UTR|RIN1_uc009yrd.1_5'UTR|RIN1_uc010roz.1_Missense_Mutation_p.Q38L|RIN1_uc010rpa.1_Missense_Mutation_p.Q38L	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	143	SH2.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						ACAGATGAGCTGGACTAGGTC	0.642		NA											19	20					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70333064	70333064	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:70333064C>A	uc001oqc.2	-	21	3412	c.3334G>T	c.(3334-3336)GTG>TTG	p.V1112L	SHANK2_uc010rqn.1_Missense_Mutation_p.V524L|SHANK2_uc001opz.2_Missense_Mutation_p.V517L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	733					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCCAGGCCCACATCCTCATCC	0.692		NA											38	846					5.44e-19	6.93e-19	1	0
MAP6	4135	broad.mit.edu	37	11	75319187	75319187	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:75319187G>C	uc001owu.2	-	2	1151	c.1086C>G	c.(1084-1086)AGC>AGG	p.S362R	MAP6_uc001owv.2_Missense_Mutation_p.S362R	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	362	Calmodulin-binding (By similarity).					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					CGCTGTAGAGGCTGCGTATTC	0.512		NA											56	25					0	0	0	0
GRM5	2915	broad.mit.edu	37	11	88781022	88781022	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:88781022G>A	uc001pcq.2	-	1	219	c.19C>T	c.(19-21)CTG>TTG	p.L7L	GRM5_uc009yvm.2_Silent_p.L7L|GRM5_uc009yvn.1_Silent_p.L7L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	7					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAGACTGACAGGATCAACAGA	0.473		NA											23	16					0	0	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714792	92714792	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:92714792G>C	uc001pdk.1	+	2	506	c.403G>C	c.(403-405)GCC>CCC	p.A135P		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	135	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CACTGCCATCGCCATTAACCG	0.597		NA											48	11					0	0	0	0
MMP10	4319	broad.mit.edu	37	11	102647451	102647451	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:102647451G>A	uc001phg.1	-	5	701	c.679C>T	c.(679-681)CAC>TAC	p.H227Y		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	227		Zinc 2; catalytic.			collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TTGGCTGAGTGAAAGAGCCCC	0.463		NA											61	22					0	0	0	0
MMP12	4321	broad.mit.edu	37	11	102742585	102742585	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:102742585T>A	uc001phk.2	-	3	493	c.448A>T	c.(448-450)AGC>TGC	p.S150C		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	150					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TTAATCTTGCTGAATTTCAAG	0.418		NA											30	2					0	0	0	0
ATM	472	broad.mit.edu	37	11	108213984	108213984	+	Silent	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:108213984A>G	uc001pkb.1	+	57	8689	c.8304A>G	c.(8302-8304)GAA>GAG	p.E2768E	ATM_uc009yxr.1_Silent_p.E2768E|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.E1420E	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2768	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGTTCTTGAATGGTGCACAG	0.403		NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			158	56					0	0	0	0
NNMT	4837	broad.mit.edu	37	11	114168790	114168790	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:114168790T>A	uc001por.1	+	4	536	c.272T>A	c.(271-273)CTG>CAG	p.L91Q	NNMT_uc001pos.1_Missense_Mutation_p.L91Q	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	91					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	GACCAGAACCTGCAGGAGCTG	0.517		NA											73	24					0	0	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117785164	117785164	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:117785164C>T	uc001prs.1	-	4	715	c.622G>A	c.(622-624)GCT>ACT	p.A208T	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.A208T	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	203	Extracellular (Potential).|SRCR.|LDL-receptor class A.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		CAGCGAACAGCGTGCTTGGGA	0.567		NA											205	77					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122850115	122850115	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:122850115C>A	uc010rzs.1	-	2	313	c.313G>T	c.(313-315)GGG>TGG	p.G105W		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	105											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CAGTGCTTCCCCGGCAGCTCC	0.667		NA											31	14					4.03e-09	4.64e-09	1	0
OR8B4	283162	broad.mit.edu	37	11	124294721	124294721	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:124294721C>A	uc010sak.1	-	1	47	c.47G>T	c.(46-48)GGA>GTA	p.G16V		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTCTGATAATCCCACAAGGAT	0.473		NA											34	9					6.71e-13	8.13e-13	1	0
KCNJ1	3758	broad.mit.edu	37	11	128709976	128709976	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:128709976C>G	uc001qeo.1	-	2	271	c.220G>C	c.(220-222)GAC>CAC	p.D74H	KCNJ1_uc001qep.1_Missense_Mutation_p.D55H|KCNJ1_uc001qeq.1_Missense_Mutation_p.D55H|KCNJ1_uc001qer.1_Missense_Mutation_p.D55H|KCNJ1_uc001qes.1_Missense_Mutation_p.D55H	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	74	Cytoplasmic (By similarity).		D -> Y (in BS2).		excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CACTTGAGGTCAAGTACCGTT	0.433		NA											103	49					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133802070	133802070	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:133802070C>G	uc001qgx.3	-	8	1237	c.1006G>C	c.(1006-1008)GTG>CTG	p.V336L	IGSF9B_uc001qgy.1_Missense_Mutation_p.V178L	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	336	Extracellular (Potential).|Ig-like 4.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCCACGGGCACGTAAATCACA	0.517		NA											8	2					0	0	0	0
ITFG2	55846	broad.mit.edu	37	12	2929961	2929961	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:2929961G>A	uc001qlb.1	+	6	682	c.618G>A	c.(616-618)GCG>GCA	p.A206A	ITFG2_uc010seb.1_Silent_p.A29A|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	206											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CAGGTTGTGCGTATGCAATTC	0.562		NA											38	63					0	0	0	0
CDCA3	83461	broad.mit.edu	37	12	6958258	6958258	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:6958258T>C	uc001qrg.2	-	6	884	c.756A>G	c.(754-756)CAA>CAG	p.Q252Q	CDCA3_uc001qre.2_Intron|uc001qrf.1_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	252					cell division|mitosis	cytosol					0						GGTCCTGGCCTTGCTCCCATG	0.532		NA											50	52					0	0	0	0
CLSTN3	9746	broad.mit.edu	37	12	7294733	7294733	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:7294733A>T	uc001qsr.2	+	10	1816	c.1538A>T	c.(1537-1539)CAA>CTA	p.Q513L	CLSTN3_uc001qss.2_Missense_Mutation_p.Q525L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	513	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GACACCACCCAAGGTACTCCG	0.458		NA									OREG0021650	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	20					0	0	0	0
CLEC6A	93978	broad.mit.edu	37	12	8630046	8630046	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:8630046A>T	uc001qum.1	+	6	733	c.616A>T	c.(616-618)AAG>TAG	p.K206*		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	206	Extracellular (Potential).				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					TGAGATGAATAAGATTTACCT	0.358		NA											47	77					0	0	0	0
A2M	2	broad.mit.edu	37	12	9262518	9262518	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:9262518C>T	uc001qvk.1	-	6	731	c.618G>A	c.(616-618)GTG>GTA	p.V206V	A2M_uc009zgk.1_Silent_p.V56V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	206					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TCTTCTGTACCACCACCTTGT	0.458		NA											127	186					0	0	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18644453	18644453	+	Silent	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:18644453T>G	uc001rdt.2	+	19	2747	c.2631T>G	c.(2629-2631)CCT>CCG	p.P877P	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.P918P|PIK3C2G_uc010sic.1_Silent_p.P696P	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	877					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTCATCTTCCTCTGAACCCTG	0.333		NA											57	85					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	21965011	21965011	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:21965011C>A	uc001rfi.1	-	34	4203	c.4183G>T	c.(4183-4185)GAT>TAT	p.D1395Y	ABCC9_uc001rfh.2_Missense_Mutation_p.D1395Y|ABCC9_uc001rfj.1_Missense_Mutation_p.D1359Y	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1395	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTATTGGATCCTGCAGAATG	0.378		NA											52	113					1.13e-26	1.54e-26	1	0
ABCC9	10060	broad.mit.edu	37	12	22028605	22028605	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:22028605T>C	uc001rfi.1	-	15	2095	c.2075A>G	c.(2074-2076)GAT>GGT	p.D692G	ABCC9_uc001rfh.2_Missense_Mutation_p.D692G|ABCC9_uc001rfj.1_Missense_Mutation_p.D656G	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	692	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATTCGAATATCTATATTGGA	0.308		NA											42	60					0	0	0	0
FGD4	121512	broad.mit.edu	37	12	32735204	32735204	+	Missense_Mutation	SNP	A	A	G	rs139620944	by1000genomes	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:32735204A>G	uc001rkz.2	+	4	880	c.403A>G	c.(403-405)ACT>GCT	p.T135A	FGD4_uc001rlc.2_Missense_Mutation_p.T220A|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.T247A|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Missense_Mutation_p.T135A	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	135	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					AAGAGATGAAACTGCCACAGC	0.493		NA											38	94					0	0	0	0
CNTN1	1272	broad.mit.edu	37	12	41422960	41422960	+	Silent	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:41422960T>A	uc001rmm.1	+	23	3032	c.2919T>A	c.(2917-2919)GTT>GTA	p.V973V	CNTN1_uc001rmn.1_Silent_p.V962V	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	973	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAGAATACGTTGTGGAGGTTC	0.448		NA											148	167					0	0	0	0
DNAJC22	79962	broad.mit.edu	37	12	49745133	49745133	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:49745133G>A	uc001rua.2	+	3	1275	c.874G>A	c.(874-876)GAA>AAA	p.E292K	DNAJC22_uc001rub.2_Missense_Mutation_p.E292K	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	292	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						AACAAATGAAGAAATACATCG	0.522		NA											33	73					0	0	0	0
SLC11A2	4891	broad.mit.edu	37	12	51388355	51388355	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:51388355G>C	uc001rxe.3	-	11	1146	c.1049C>G	c.(1048-1050)TCG>TGG	p.S350W	SLC11A2_uc001rxd.3_Missense_Mutation_p.S199W|SLC11A2_uc001rxc.3_Missense_Mutation_p.S350W|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_5'UTR|SLC11A2_uc010smx.1_Missense_Mutation_p.S346W|SLC11A2_uc001rxh.1_Missense_Mutation_p.S350W|SLC11A2_uc001rxj.1_Missense_Mutation_p.S350W|SLC11A2_uc001rxi.2_Missense_Mutation_p.S350W|SLC11A2_uc001rxk.1_Missense_Mutation_p.S379W|SLC11A2_uc010smy.1_Missense_Mutation_p.S313W	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	350	Extracellular (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						AGCCAGTGTCGAGTTATCTTT	0.403		NA											57	95					0	0	0	0
KRT73	319101	broad.mit.edu	37	12	53012037	53012037	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:53012037A>G	uc001sas.2	-	1	307	c.272T>C	c.(271-273)TTG>TCG	p.L91S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	91	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CACGGACCCCAAGGCCACACT	0.627		NA											111	162					0	0	0	0
HOXC13	3229	broad.mit.edu	37	12	54338804	54338804	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:54338804G>A	uc001sei.2	+	2	872	c.757G>A	c.(757-759)GAG>AAG	p.E253K	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	253						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CCTGCAGCCCGAGGTGAGCAG	0.607		NA	T	NUP98	AML								148	213					0	0	0	0
AVIL	10677	broad.mit.edu	37	12	58197112	58197112	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:58197112T>G	uc001sqj.1	-	15	1909	c.1880A>C	c.(1879-1881)CAA>CCA	p.Q627P	AVIL_uc009zqe.1_Missense_Mutation_p.Q620P|AVIL_uc001sqk.1_Missense_Mutation_p.Q205P	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	627	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GACAACGAATTGGCCGGTCTT	0.478		NA									OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	139	214					0	0	0	0
PTPRB	5787	broad.mit.edu	37	12	70928431	70928431	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:70928431C>T	uc001swb.3	-	29	5581	c.5551G>A	c.(5551-5553)GAG>AAG	p.E1851K	uc001svz.2_Intron|PTPRB_uc010sto.1_Missense_Mutation_p.E1761K|PTPRB_uc010stp.1_Missense_Mutation_p.E1761K|PTPRB_uc001swc.3_Missense_Mutation_p.E2069K|PTPRB_uc001swa.3_Missense_Mutation_p.E1981K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1851	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCTGTTCCTCCTGTAAGAGC	0.493		NA											17	18					0	0	0	0
OSBPL8	114882	broad.mit.edu	37	12	76791585	76791585	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:76791585C>A	uc001sye.1	-	8	1041	c.561G>T	c.(559-561)TGG>TGT	p.W187C	OSBPL8_uc001syf.1_Missense_Mutation_p.W145C|OSBPL8_uc001syg.1_Missense_Mutation_p.W145C|OSBPL8_uc001syh.1_Missense_Mutation_p.W162C	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	187	PH.				lipid transport		lipid binding			ovary(1)	1						CTGTTCCTACCCACTGACCAT	0.398		NA											48	71					1.01e-21	1.31e-21	1	0
DEPDC4	120863	broad.mit.edu	37	12	100660775	100660775	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:100660775T>C	uc001thi.2	-	1	83	c.80A>G	c.(79-81)AAC>AGC	p.N27S	SCYL2_uc009ztw.1_5'Flank|SCYL2_uc001thm.1_5'Flank|SCYL2_uc001thn.2_5'Flank|DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.N27S|DEPDC4_uc009ztv.1_Missense_Mutation_p.N27S|DEPDC4_uc001thk.1_5'UTR|DEPDC4_uc001thl.1_RNA	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	27					intracellular signal transduction						0						CGGAAGCTCGTTCTGACTGAC	0.602		NA											97	119					0	0	0	0
SLC5A8	160728	broad.mit.edu	37	12	101603501	101603501	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:101603501G>A	uc001thz.3	-	1	516	c.126C>T	c.(124-126)TCC>TCT	p.S42S		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	42	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GGAAGTCCTTGGAGGTCTGCT	0.657		NA											25	38					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104054129	104054129	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:104054129A>T	uc001tjw.2	+	16	1941	c.1755A>T	c.(1753-1755)GAA>GAT	p.E585D		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	585	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGCTTCTGGAACTCGTCAGAT	0.438		NA											146	219					0	0	0	0
POLR3B	55703	broad.mit.edu	37	12	106760311	106760311	+	Silent	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:106760311A>G	uc001tlp.2	+	3	345	c.123A>G	c.(121-123)AAA>AAG	p.K41K	POLR3B_uc001tlq.2_5'UTR	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	41					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						GCCTTGTGAAACAGCATATAG	0.318		NA											45	44					0	0	0	0
USP30	84749	broad.mit.edu	37	12	109522854	109522854	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:109522854C>T	uc010sxi.1	+	12	1369	c.1265C>T	c.(1264-1266)CCT>CTT	p.P422L	USP30_uc001tnu.3_Missense_Mutation_p.P391L|USP30_uc001tnw.3_Missense_Mutation_p.P139L	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	422	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						ATGCCCTTCCCTCTCCCAGTT	0.507		NA											250	374					0	0	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124221737	124221737	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:124221737G>T	uc001ufr.2	+	9	1205	c.957G>T	c.(955-957)GTG>GTT	p.V319V	ATP6V0A2_uc001ufq.1_Silent_p.V319V	NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	319	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		GCTTTGACGTGACCAACAAGT	0.562		NA											51	68					6.17e-35	8.81e-35	1	0
TMEM132D	121256	broad.mit.edu	37	12	129559181	129559181	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:129559181T>G	uc009zyl.1	-	9	2867	c.2539A>C	c.(2539-2541)ATG>CTG	p.M847L	TMEM132D_uc001uia.2_Missense_Mutation_p.M385L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	847	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATGAGTCCCATAGAAGAACTG	0.527		NA											62	87					0	0	0	0
TPTE2	93492	broad.mit.edu	37	13	20039644	20039644	+	Silent	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:20039644A>T	uc001umd.2	-	9	784	c.573T>A	c.(571-573)CTT>CTA	p.L191L	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Silent_p.L80L|TPTE2_uc001ume.2_Silent_p.L114L|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	191						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TTTTTTGATGAAGCAGATGAA	0.333		NA											28	11					0	0	0	0
ATP8A2	51761	broad.mit.edu	37	13	26129169	26129169	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:26129169T>A	uc001uqk.2	+	13	1368	c.1226T>A	c.(1225-1227)ATG>AAG	p.M409K	ATP8A2_uc010tdi.1_Missense_Mutation_p.M369K|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.M369K	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	369	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACTCCTGCCATGGCCAGGACA	0.418		NA											61	19					0	0	0	0
RXFP2	122042	broad.mit.edu	37	13	32339279	32339279	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:32339279T>A	uc001utt.2	+	4	496	c.425T>A	c.(424-426)CTG>CAG	p.L142Q	RXFP2_uc010aba.2_Missense_Mutation_p.L125Q	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	142	LRR 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GTGACATTACTGTGAGTAAAA	0.343		NA											38	12					0	0	0	0
SIAH3	283514	broad.mit.edu	37	13	46357979	46357979	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:46357979C>A	uc001vap.2	-	2	431	c.349G>T	c.(349-351)GAA>TAA	p.E117*		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	117	SIAH-type; degenerate.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						AGGCGGCCTTCCCACTGGCAG	0.562		NA											55	24					4.67e-28	6.44e-28	1	0
SLITRK5	26050	broad.mit.edu	37	13	88329715	88329715	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:88329715G>T	uc001vln.2	+	2	2291	c.2072G>T	c.(2071-2073)CGC>CTC	p.R691L	SLITRK5_uc010tic.1_Missense_Mutation_p.R450L	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	691	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTCATGAAGCGCAGGAAGAAG	0.602		NA											25	18					1.55e-16	1.94e-16	1	0
OR4K1	79544	broad.mit.edu	37	14	20403895	20403895	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:20403895C>T	uc001vwj.1	+	1	70	c.70C>T	c.(70-72)CAA>TAA	p.Q24*		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTGGGGACTTCAACTTTTCTT	0.358		NA											196	326					0	0	0	0
OR11G2	390439	broad.mit.edu	37	14	20666109	20666109	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:20666109C>A	uc010tlb.1	+	1	615	c.615C>A	c.(613-615)TCC>TCA	p.S205S		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	205	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CCCAAATGTCCTTCTGTGGAT	0.443		NA											59	19					8.29e-21	1.07e-20	1	0
TEP1	7011	broad.mit.edu	37	14	20846329	20846329	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:20846329C>G	uc001vxe.2	-	39	5615	c.5575G>C	c.(5575-5577)GTG>CTG	p.V1859L	TEP1_uc010ahk.2_Missense_Mutation_p.V1202L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.V1751L|TEP1_uc010tlh.1_Missense_Mutation_p.V197L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1859	WD 6.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCCGGCCCACAGCCACAACC	0.622		NA											47	15					0	0	0	0
MYH6	4624	broad.mit.edu	37	14	23866242	23866242	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:23866242C>T	uc001wjv.2	-	18	2165	c.2098G>A	c.(2098-2100)GTG>ATG	p.V700M		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	700	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCCTCCAGCACGCCATTGCAG	0.617		NA											43	13					0	0	0	0
NPAS3	64067	broad.mit.edu	37	14	34247672	34247672	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:34247672G>C	uc001wru.2	+	9	1111	c.1047G>C	c.(1045-1047)AGG>AGC	p.R349S	NPAS3_uc001wrs.2_Missense_Mutation_p.R336S|NPAS3_uc001wrt.2_Missense_Mutation_p.R317S|NPAS3_uc001wrv.2_Missense_Mutation_p.R319S	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	349	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CTCTTTGTAGGATTAGTGATT	0.403		NA											63	19					0	0	0	0
MAP4K5	11183	broad.mit.edu	37	14	50912808	50912808	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:50912808G>A	uc001wya.2	-	17	1494	c.1174C>T	c.(1174-1176)CTA>TTA	p.L392L	MAP4K5_uc001wyb.2_Silent_p.L392L|MAP4K5_uc010anv.1_Silent_p.L392L|MAP4K5_uc001wyc.1_Silent_p.L66L	NM_006575	NP_006566	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase	392					activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)					TTAGGAGGTAGGGGAGGTGGT	0.274		NA											9	6					0	0	0	0
RGS6	9628	broad.mit.edu	37	14	72939588	72939588	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:72939588G>A	uc001xna.3	+	9	1068	c.545G>A	c.(544-546)CGG>CAG	p.R182Q	RGS6_uc010ttn.1_Missense_Mutation_p.R182Q|RGS6_uc001xmx.3_Missense_Mutation_p.R182Q|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.R182Q|RGS6_uc010ttp.1_Missense_Mutation_p.R113Q|RGS6_uc001xmz.1_Missense_Mutation_p.R43Q|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	182					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		AGGATTGACCGGAAAAAAGAC	0.448		NA											125	56					0	0	0	0
GALC	2581	broad.mit.edu	37	14	88411945	88411945	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:88411945C>T	uc001xvt.2	-	14	2021	c.1622G>A	c.(1621-1623)TGG>TAG	p.W541*	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Nonsense_Mutation_p.W515*|GALC_uc010tvy.1_Nonsense_Mutation_p.W518*|GALC_uc010tvz.1_Nonsense_Mutation_p.W485*	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	541					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						ATCGGCAGCCCATGTAATGGG	0.418		NA											57	21					0	0	0	0
TTC8	123016	broad.mit.edu	37	14	89338730	89338730	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:89338730C>A	uc010ath.2	+	13	1463	c.1329C>A	c.(1327-1329)AAC>AAA	p.N443K	TTC8_uc001xxl.2_Missense_Mutation_p.N188K|TTC8_uc010ati.2_Missense_Mutation_p.N229K|TTC8_uc001xxm.2_Missense_Mutation_p.N387K|TTC8_uc010atj.2_Missense_Mutation_p.N162K|TTC8_uc001xxi.2_Missense_Mutation_p.N427K|TTC8_uc001xxj.2_Missense_Mutation_p.N417K|TTC8_uc001xxk.2_Missense_Mutation_p.N387K	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	453	TPR 7.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						TGGTCAACAACAACAACCACG	0.532		NA							Bardet-Biedl_syndrome				63	18					1.13e-26	1.54e-26	1	0
SLC24A4	123041	broad.mit.edu	37	14	92959954	92959954	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:92959954G>A	uc001yak.2	+	17	1824	c.1800G>A	c.(1798-1800)ATG>ATA	p.M600I	SLC24A4_uc001yai.2_Missense_Mutation_p.M553I|SLC24A4_uc010twm.1_Missense_Mutation_p.M598I|SLC24A4_uc001yaj.2_Missense_Mutation_p.M581I|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.M373I|SLC24A4_uc001yan.2_Missense_Mutation_p.M311I	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	617	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		ACTTGCCGATGTGCCGGGAAG	0.562		NA											25	2					0	0	0	0
DICER1	23405	broad.mit.edu	37	14	95595897	95595897	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:95595897G>A	uc001ydw.2	-	7	828	c.646C>T	c.(646-648)CCA>TCA	p.P216S	DICER1_uc001ydv.2_Missense_Mutation_p.P206S|DICER1_uc001ydx.2_Missense_Mutation_p.P216S	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	216	Helicase ATP-binding.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AATTCCTCTGGATCACATTTC	0.373		NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				61	21					0	0	0	0
ATG2B	55102	broad.mit.edu	37	14	96777573	96777573	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:96777573T>A	uc001yfi.2	-	28	4407	c.4042A>T	c.(4042-4044)ACG>TCG	p.T1348S		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1348										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TCTGAGCACGTTCTGATATGG	0.448		NA											113	33					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24921370	24921370	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:24921370C>T	uc001ywo.2	+	1	830	c.356C>T	c.(355-357)CCC>CTC	p.P119L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	119					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ATCCCTCCTCCCAGCCGCATG	0.652		NA											71	89					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24922340	24922340	+	Silent	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:24922340T>G	uc001ywo.2	+	1	1800	c.1326T>G	c.(1324-1326)CCT>CCG	p.P442P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	442	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGCCTATCCCTCCACTTTCCA	0.527		NA											60	100					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	26026341	26026341	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:26026341C>A	uc010ayu.2	-	2	585	c.479G>T	c.(478-480)TGG>TTG	p.W160L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	160	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GATTTCTTTCCAGAATCGGTT	0.363		NA											25	26					4.4e-07	4.92e-07	1	0
BUB1B	701	broad.mit.edu	37	15	40488910	40488910	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:40488910G>A	uc001zkx.3	+	9	1435	c.1223G>A	c.(1222-1224)GGG>GAG	p.G408E	BUB1B_uc010ucl.1_Missense_Mutation_p.G271E	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	408					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GCAGGAGTAGGGGAATTCTCC	0.418		NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				4	138					0	0	0	0
ADAL	161823	broad.mit.edu	37	15	43627996	43627996	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:43627996G>A	uc010udo.1	+	5	740	c.166G>A	c.(166-168)GAC>AAC	p.D56N	ADAL_uc001zrh.2_Missense_Mutation_p.D56N	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	56					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GACTGTGATTGACAAGGGAAA	0.378		NA											88	110					0	0	0	0
SHF	90525	broad.mit.edu	37	15	45460274	45460274	+	Silent	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:45460274C>G	uc001zuy.2	-	8	1638	c.1143G>C	c.(1141-1143)GTG>GTC	p.V381V	SHF_uc010uen.1_Silent_p.V197V|SHF_uc010ueo.1_Silent_p.V197V|SHF_uc010uep.1_3'UTR|SHF_uc010ueq.1_Silent_p.V157V|SHF_uc010uer.1_3'UTR	NM_138356	NP_612365	Q7M4L6	SHF_HUMAN	Src homology 2 domain containing F	Error:Variant_position_missing_in_B3KTY1_after_alignment										ovary(1)	1		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		TCTGGCCCAGCACATATTTGT	0.572		NA									OREG0023104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	44					0	0	0	0
SLC24A5	283652	broad.mit.edu	37	15	48428997	48428997	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:48428997C>A	uc001zwe.2	+	6	781	c.708C>A	c.(706-708)GCC>GCA	p.A236A	SLC24A5_uc010bel.2_Silent_p.A176A|uc001zwf.1_5'Flank	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	236	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		CCTGTCTTGCCAAAGCTATGG	0.388		NA											28	36					4.78e-09	5.49e-09	1	0
ATP8B4	79895	broad.mit.edu	37	15	50336882	50336882	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:50336882G>T	uc001zxu.2	-	5	351	c.209C>A	c.(208-210)CCA>CAA	p.P70Q	ATP8B4_uc010ber.2_5'UTR|ATP8B4_uc010ufd.1_5'UTR|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	70	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGAAATTTCTGGAATTAGCTG	0.353		NA											22	37					1.11e-12	1.34e-12	1	0
TRPM7	54822	broad.mit.edu	37	15	50929755	50929755	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:50929755C>A	uc001zyt.3	-	7	960	c.696G>T	c.(694-696)CTG>CTT	p.L232L	TRPM7_uc010bew.1_Silent_p.L232L	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	232	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCAATTTGCTCAGGGGGTTCA	0.373		NA											57	57					1.55e-18	1.96e-18	1	0
UNC13C	440279	broad.mit.edu	37	15	54307549	54307549	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:54307549C>A	uc002ack.2	+	1	2449	c.2449C>A	c.(2449-2451)CAG>AAG	p.Q817K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	817					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAAAAGCACACAGAGTCTGAG	0.428		NA											33	45					1.6e-16	2e-16	1	0
UNC13C	440279	broad.mit.edu	37	15	54307585	54307585	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:54307585T>C	uc002ack.2	+	1	2485	c.2485T>C	c.(2485-2487)TTA>CTA	p.L829L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	829					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGGCTCTTCATTAATGGGGAG	0.428		NA											40	39					0	0	0	0
VPS13C	54832	broad.mit.edu	37	15	62312738	62312738	+	Splice_Site	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:62312738C>A	uc002agz.2	-	9	699	c.625_splice	c.e9-1	p.V209_splice	VPS13C_uc002aha.2_Splice_Site_p.V166_splice|VPS13C_uc002ahb.1_Splice_Site_p.V209_splice|VPS13C_uc002ahc.1_Splice_Site_p.V166_splice	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2						GATCAGTGACCTACCAAAGAA	0.403		NA											37	45					8.69e-16	1.08e-15	1	0
PLEKHO2	80301	broad.mit.edu	37	15	65157206	65157206	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:65157206G>C	uc002anv.2	+	6	726	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Missense_Mutation_p.E148Q	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	198	Pro-rich.									ovary(1)|lung(1)	2						CCAACCTCGGGAGACACCCCG	0.622		NA											59	149					0	0	0	0
DENND4A	10260	broad.mit.edu	37	15	65994823	65994823	+	Silent	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:65994823T>G	uc002aph.2	-	17	2628	c.2250A>C	c.(2248-2250)GCA>GCC	p.A750A	DENND4A_uc002api.2_Silent_p.A750A|DENND4A_uc002apj.3_Silent_p.A750A	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGTACCTCTTTGCAATTTTAT	0.373		NA											6	4					0	0	0	0
ARID3B	10620	broad.mit.edu	37	15	74865224	74865224	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:74865224G>A	uc002aye.2	+	3	775	c.574G>A	c.(574-576)GAT>AAT	p.D192N	ARID3B_uc002ayc.2_Missense_Mutation_p.D192N|ARID3B_uc002ayd.2_Missense_Mutation_p.D192N	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						GGCCTGGAGTGATGATGCAGA	0.473		NA											35	79					0	0	0	0
LINGO1	84894	broad.mit.edu	37	15	77907035	77907035	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:77907035T>A	uc002bct.1	-	2	1266	c.1214A>T	c.(1213-1215)AAG>ATG	p.K405M	LINGO1_uc002bcu.1_Missense_Mutation_p.K399M	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	405	Extracellular (Potential).|LRRCT.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						CTTGAACTCCTTGCCCTGGAC	0.662		NA											7	11					0	0	0	0
BCL2A1	597	broad.mit.edu	37	15	80263104	80263104	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:80263104A>G	uc002bfc.3	-	1	540	c.358T>C	c.(358-360)TAT>CAT	p.Y120H	BCL2A1_uc002bfd.3_Missense_Mutation_p.Y120H	NM_004049	NP_004040	Q16548	B2LA1_HUMAN	BCL2-related protein A1 isoform 1	120					anti-apoptosis|apoptosis	cytoplasm	protein binding			pancreas(1)	1						GCAACAAAATATGAAATCTCC	0.388		NA											133	171					0	0	0	0
ACAN	176	broad.mit.edu	37	15	89388786	89388786	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:89388786G>A	uc010upo.1	+	7	1476	c.1102G>A	c.(1102-1104)GAG>AAG	p.E368K	ACAN_uc002bmx.2_Missense_Mutation_p.E368K|ACAN_uc010upp.1_Missense_Mutation_p.E368K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	368					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGGGGGTGAGGAGGACATCAC	0.572		NA											28	38					0	0	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147209	26147209	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:26147209G>T	uc002dof.2	+	2	1403	c.1011G>T	c.(1009-1011)GCG>GCT	p.A337A		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	337	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GGATCTATGCGCTGCATCTGG	0.557		NA											138	44					1.37e-54	2.07e-54	1	0
NKD1	85407	broad.mit.edu	37	16	50667328	50667328	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:50667328A>G	uc002egg.1	+	10	1273	c.1049A>G	c.(1048-1050)AAG>AGG	p.K350R		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	350					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		AGGTCCCCCAAGGCCCAGGGC	0.662		NA											53	10					0	0	0	0
CAPNS2	84290	broad.mit.edu	37	16	55601279	55601279	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:55601279T>C	uc002eid.1	+	1	696	c.611T>C	c.(610-612)ATG>ACG	p.M204T	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	204	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding				0						GATGGAGATATGGATTTTAAC	0.478		NA											198	66					0	0	0	0
C16orf70	80262	broad.mit.edu	37	16	67168322	67168322	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:67168322C>T	uc002erc.2	+	9	697	c.613C>T	c.(613-615)CGA>TGA	p.R205*	C16orf70_uc002erd.2_Nonsense_Mutation_p.R205*|C16orf70_uc002ere.1_3'UTR	NM_025187	NP_079463	Q9BSU1	CP070_HUMAN	lin-10	205										ovary(2)	2		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		AGATGTTCTTCGAGATGGAAC	0.512		NA											246	77					0	0	0	0
CENPT	80152	broad.mit.edu	37	16	67862385	67862385	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:67862385C>T	uc002eun.3	-	15	2103	c.1554G>A	c.(1552-1554)CTG>CTA	p.L518L	CENPT_uc002eum.3_Silent_p.L463L|CENPT_uc010vkc.1_3'UTR|CENPT_uc010vkd.1_Silent_p.L271L	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	518					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		ACCGCCGCATCAGCAGCTCCA	0.562		NA											109	31					0	0	0	0
DDX28	55794	broad.mit.edu	37	16	68056395	68056395	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:68056395C>A	uc002evh.1	-	1	1565	c.711G>T	c.(709-711)CTG>CTT	p.L237L	DUS2L_uc002evi.2_5'Flank|DUS2L_uc002evj.2_5'Flank|DUS2L_uc010vkk.1_5'Flank	NM_018380	NP_060850	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	237	Helicase ATP-binding.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		GGCCTCCCTCCAGGTCCCGCA	0.657		NA											30	8					7.68e-24	1.03e-23	1	0
HYDIN	54768	broad.mit.edu	37	16	70989378	70989378	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:70989378C>A	uc002ezr.2	-	40	6341	c.6213G>T	c.(6211-6213)CTG>CTT	p.L2071L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2072										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCACAGCTTCCAGCACAATGG	0.557		NA											48	15					2.95e-30	4.11e-30	1	0
GLG1	2734	broad.mit.edu	37	16	74519693	74519693	+	Splice_Site	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:74519693C>T	uc002fcy.3	-	9	1621	c.1571_splice	c.e9+1	p.M524_splice	GLG1_uc002fcx.2_Splice_Site_p.M524_splice|GLG1_uc002fcw.3_Splice_Site_p.M513_splice|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3							Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						AGATAACTTACATTGGGTCTC	0.408		NA											68	23					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577610	7577610	+	Splice_Site	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:7577610T>C	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.2_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(22)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGAGCCAACCTAGGAGATAAC	0.483		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			53	10					0	0	0	0
MYH10	4628	broad.mit.edu	37	17	8526248	8526248	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:8526248T>C	uc002gll.2	-	2	413	c.317A>G	c.(316-318)AAG>AGG	p.K106R	MYH10_uc002glm.2_Missense_Mutation_p.K106R|MYH10_uc010cnx.2_Missense_Mutation_p.K106R	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	106	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GTAGCGATCCTTCAGATTATG	0.343		NA											93	112					0	0	0	0
DHRS7C	201140	broad.mit.edu	37	17	9683345	9683345	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:9683345G>T	uc010vvb.1	-	3	278	c.278C>A	c.(277-279)ACC>AAC	p.T93N	DHRS7C_uc010cof.2_Missense_Mutation_p.T92N	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	93						extracellular region	binding|oxidoreductase activity				0						CAGCTTTGGGGTGAATGTCTG	0.507		NA											16	31					6.94e-10	8.11e-10	1	0
MYH13	8735	broad.mit.edu	37	17	10265781	10265781	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:10265781G>T	uc002gmk.1	-	4	334	c.244C>A	c.(244-246)CCT>ACT	p.P82T		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	82	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AATTTGGGAGGGTTCATGGGG	0.478		NA											94	164					1.53e-54	2.31e-54	1	0
MYH1	4619	broad.mit.edu	37	17	10408506	10408506	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:10408506C>A	uc002gmo.2	-	21	2503	c.2409G>T	c.(2407-2409)GTG>GTT	p.V803V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	803	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCTGGTACTCCACTCTTGCCA	0.433		NA											44	114					1.24e-20	1.59e-20	1	0
DNAH9	1770	broad.mit.edu	37	17	11607761	11607761	+	Splice_Site	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:11607761T>C	uc002gne.2	+	25	5459	c.5391_splice	c.e25+2	p.K1797_splice	DNAH9_uc010coo.2_Splice_Site_p.K1091_splice	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCTCAGAAGGTGGGTCCCAAA	0.522		NA											28	55					0	0	0	0
MEOX1	4222	broad.mit.edu	37	17	41738516	41738516	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:41738516G>A	uc002idz.2	-	1	416	c.387C>T	c.(385-387)GGC>GGT	p.G129G	MEOX1_uc002iea.2_Silent_p.G129G|MEOX1_uc002ieb.2_Silent_p.G14G	NM_004527	NP_004518	P50221	MEOX1_HUMAN	mesenchyme homeobox 1 isoform 1	129						nucleus	sequence-specific DNA binding				0		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		CATCGCCTGGGCCTCCTGTGG	0.627		NA											150	199					0	0	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476285	42476285	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:42476285T>A	uc002igw.1	-	8	3224	c.3160A>T	c.(3160-3162)AGA>TGA	p.R1054*	GPATCH8_uc002igv.1_Nonsense_Mutation_p.R976*|GPATCH8_uc010wiz.1_Nonsense_Mutation_p.R976*	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1054						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TCATCTCCTCTGCCATCATCT	0.537		NA											55	65					0	0	0	0
MRC2	9902	broad.mit.edu	37	17	60755933	60755933	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:60755933G>T	uc002jad.2	+	13	2523	c.2121G>T	c.(2119-2121)CTG>CTT	p.L707L	MRC2_uc010ddq.1_RNA|MRC2_uc002jae.2_5'Flank|MRC2_uc002jaf.2_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	707	Extracellular (Potential).|C-type lectin 4.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GCCAGGAGCTGGGGGCCCAGC	0.627		NA											20	31					3.01e-09	3.48e-09	1	0
TANC2	26115	broad.mit.edu	37	17	61489388	61489388	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:61489388G>A	uc002jal.3	+	21	3596	c.3573G>A	c.(3571-3573)ATG>ATA	p.M1191I	TANC2_uc010wpe.1_Missense_Mutation_p.M1101I|TANC2_uc002jao.3_Missense_Mutation_p.M292I	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1191	ANK 10.						binding			ovary(2)	2						ATGGGGCCATGATCGAGCACG	0.542		NA											43	41					0	0	0	0
DDX42	11325	broad.mit.edu	37	17	61893008	61893008	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:61893008G>T	uc002jbu.2	+	17	2245	c.1988G>T	c.(1987-1989)CGG>CTG	p.R663L	DDX42_uc002jbv.2_Missense_Mutation_p.R663L|DDX42_uc002jbx.2_Missense_Mutation_p.R399L|DDX42_uc002jby.2_Missense_Mutation_p.R209L|DDX42_uc010wps.1_Missense_Mutation_p.R31L	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	663					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						TACAGGGAGCGGCCTGGCCTG	0.463		NA											47	101					2.75e-27	3.76e-27	1	0
TEX2	55852	broad.mit.edu	37	17	62291206	62291206	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:62291206T>C	uc002jec.2	-	2	545	c.372A>G	c.(370-372)GCA>GCG	p.A124A	TEX2_uc002jed.2_Silent_p.A124A|TEX2_uc002jee.2_Silent_p.A124A	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	124					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TTAATACTTGTGCTGCTGGAA	0.562		NA											107	118					0	0	0	0
ABCA9	10350	broad.mit.edu	37	17	67041454	67041454	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:67041454C>G	uc002jhu.2	-	4	471	c.328G>C	c.(328-330)GAT>CAT	p.D110H	ABCA9_uc010dez.2_Missense_Mutation_p.D110H|ABCA9_uc002jhv.2_Missense_Mutation_p.D110H	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	110					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CTTTTTTCATCAGGCCACCCC	0.378		NA											61	123					0	0	0	0
TRIM47	91107	broad.mit.edu	37	17	73871028	73871028	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:73871028C>A	uc002jpw.2	-	6	1480	c.1453G>T	c.(1453-1455)GAG>TAG	p.E485*	TRIM47_uc002jpv.2_Nonsense_Mutation_p.E247*	NM_033452	NP_258411	Q96LD4	TRI47_HUMAN	tripartite motif-containing 47	485	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATCTCCACCTCCCAGTAGTAG	0.647		NA											50	68					5.39e-20	6.91e-20	1	0
FASN	2194	broad.mit.edu	37	17	80041269	80041269	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:80041269G>A	uc002kdu.2	-	32	5491	c.5374C>T	c.(5374-5376)CAC>TAC	p.H1792Y	FASN_uc002kdv.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1792	Enoyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	AGGACCCCGTGGAATGTCACG	0.652		NA											35	48					0	0	0	0
CCDC57	284001	broad.mit.edu	37	17	80159756	80159756	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:80159756C>T	uc002kdz.1	-	3	420	c.65G>A	c.(64-66)AGG>AAG	p.R22K	CCDC57_uc002kdx.1_Missense_Mutation_p.R22K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	22										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CTGCAGCGCCCTCCACTCCTC	0.657		NA											13	34					0	0	0	0
NDC80	10403	broad.mit.edu	37	18	2610796	2610796	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:2610796G>A	uc002kli.2	+	16	1909	c.1727G>A	c.(1726-1728)CGA>CAA	p.R576Q		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	576	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						GAAGAAAGACGAAAAGTGGGA	0.378		NA											85	132					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7016587	7016587	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:7016587C>A	uc002knm.2	-	21	2986	c.2892G>T	c.(2890-2892)ACG>ACT	p.T964T	LAMA1_uc010wzj.1_Silent_p.T440T	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	964	Laminin EGF-like 10.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCCTTCATCCGTGCAGCCAT	0.592		NA											27	19					1.75e-11	2.09e-11	1	0
TUBB6	84617	broad.mit.edu	37	18	12325303	12325303	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:12325303C>T	uc002kqw.2	+	4	560	c.515C>T	c.(514-516)TCG>TTG	p.S172L	TUBB6_uc002kqv.2_Missense_Mutation_p.S100L|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Missense_Mutation_p.S135L|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	172					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		GTCATGCCCTCGCCCAAGGTG	0.617		NA											98	103					0	0	0	0
ROCK1	6093	broad.mit.edu	37	18	18535194	18535194	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:18535194G>C	uc002kte.2	-	30	4466	c.3525C>G	c.(3523-3525)CAC>CAG	p.H1175Q		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1175	PH.|Auto-inhibitory.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CAGGTCTAACGTGAAACAGTT	0.229		NA											14	23					0	0	0	0
MAPRE2	10982	broad.mit.edu	37	18	32681988	32681988	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:32681988G>C	uc002kyg.2	+	4	655	c.475G>C	c.(475-477)GAT>CAT	p.D159H	MAPRE2_uc010xcb.1_Missense_Mutation_p.D116H|MAPRE2_uc010xcc.1_Missense_Mutation_p.D147H|MAPRE2_uc002kyf.2_Missense_Mutation_p.D159H|MAPRE2_uc002kyh.2_Missense_Mutation_p.D106H|MAPRE2_uc010xcd.1_Missense_Mutation_p.D116H	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	159	CH.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						GAAATTCTATGATGCTAACTA	0.423		NA											44	54					0	0	0	0
LIPG	9388	broad.mit.edu	37	18	47108775	47108775	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:47108775C>T	uc002ldv.2	+	7	1332	c.1080C>T	c.(1078-1080)AAC>AAT	p.N360N	LIPG_uc010xdh.1_Silent_p.N286N	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	360	PLAT.				cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						GTTACAAGAACATGGGAGAAA	0.443		NA											43	89					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50450086	50450086	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:50450086T>A	uc002lfe.1	+	4	1294	c.707T>A	c.(706-708)CTG>CAG	p.L236Q	DCC_uc010xdr.1_Missense_Mutation_p.L84Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	236	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GATCCAGGACTGCATAGACAG	0.363		NA											39	97					0	0	0	0
DCC	1630	broad.mit.edu	37	18	51013172	51013172	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:51013172G>C	uc002lfe.1	+	26	4329	c.3742G>C	c.(3742-3744)GTG>CTG	p.V1248L	DCC_uc010dpf.1_Missense_Mutation_p.V883L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1248	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGCAGCTGTCGTGAGCGCCAT	0.488		NA											80	100					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63489364	63489364	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:63489364C>A	uc002ljz.2	+	5	998	c.673C>A	c.(673-675)CAG>AAG	p.Q225K	CDH7_uc002lka.2_Missense_Mutation_p.Q225K|CDH7_uc002lkb.2_Missense_Mutation_p.Q225K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	225	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GGCTAAAGACCAGTATTTGCT	0.403		NA											43	60					1.03e-13	1.25e-13	1	0
ZNF407	55628	broad.mit.edu	37	18	72344239	72344239	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:72344239G>T	uc002llw.2	+	1	1321	c.1264G>T	c.(1264-1266)GTG>TTG	p.V422L	ZNF407_uc010xfc.1_Missense_Mutation_p.V422L|ZNF407_uc010dqu.1_Missense_Mutation_p.V422L|ZNF407_uc002llu.2_Missense_Mutation_p.V421L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AAATATTCTCGTGTTGGGTAA	0.433		NA											51	63					2.75e-27	3.76e-27	1	0
PIP5K1C	23396	broad.mit.edu	37	19	3664871	3664871	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:3664871C>T	uc002lyj.1	-	3	225	c.168G>A	c.(166-168)AAG>AAA	p.K56K	PIP5K1C_uc010xhq.1_Silent_p.K56K|PIP5K1C_uc010xhr.1_Silent_p.K56K	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	56					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GGCCCAACTTCTTCCCATGGC	0.632		NA											90	121					0	0	0	0
ANKRD24	170961	broad.mit.edu	37	19	4200161	4200161	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:4200161C>T	uc010dtt.1	+	5	612	c.336C>T	c.(334-336)GAC>GAT	p.D112D	ANKRD24_uc002lzs.2_Silent_p.D83D|ANKRD24_uc002lzt.2_Silent_p.D84D	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	112											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGAGCGCGGACGGGGCAGGTA	0.652		NA											3	17					0	0	0	0
KDM4B	23030	broad.mit.edu	37	19	5134010	5134010	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:5134010G>T	uc002mbq.3	+	14	2249	c.2023G>T	c.(2023-2025)GCA>TCA	p.A675S	KDM4B_uc010xim.1_Missense_Mutation_p.A709S|KDM4B_uc002mbr.3_Missense_Mutation_p.A433S	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	675					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						GAAGTTCAACGCAGCGGCTGC	0.667		NA											93	139					7.04e-44	1.04e-43	1	0
TMEM146	257062	broad.mit.edu	37	19	5727297	5727297	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:5727297C>A	uc002mda.2	+	3	206	c.145C>A	c.(145-147)CCT>ACT	p.P49T	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	49	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTATTTTCATCCTACAACAAC	0.284		NA											61	76					9.04e-38	1.3e-37	1	0
TNFSF14	8740	broad.mit.edu	37	19	6664993	6664993	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:6664993G>A	uc002mfk.1	-	5	1049	c.667C>T	c.(667-669)CGC>TGC	p.R223C	TNFSF14_uc002mfj.1_Missense_Mutation_p.R187C	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	223	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CGAACCAGGCGTTCATCCAGC	0.612		NA											109	155					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9007503	9007503	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:9007503G>T	uc002mkp.2	-	43	39669	c.39465C>A	c.(39463-39465)CCC>CCA	p.P13155P	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGGGGACGGGGGATGGAG	0.463		NA											13	32					3.33e-07	3.73e-07	1	0
MUC16	94025	broad.mit.edu	37	19	9026207	9026207	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:9026207C>A	uc002mkp.2	-	14	36983	c.36779G>T	c.(36778-36780)AGT>ATT	p.S12260I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12262	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAGGACACTCTCCATGGT	0.552		NA											143	192					6.37e-58	9.67e-58	1	0
MUC16	94025	broad.mit.edu	37	19	9072003	9072003	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:9072003G>T	uc002mkp.2	-	3	15647	c.15443C>A	c.(15442-15444)CCC>CAC	p.P5148H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5150	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGGCTTTGGGTGTCTCTGA	0.458		NA											132	167					5.81e-51	8.72e-51	1	0
ILF3	3609	broad.mit.edu	37	19	10794209	10794209	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:10794209T>C	uc002mpn.2	+	15	2159	c.1842T>C	c.(1840-1842)TTT>TTC	p.F614F	ILF3_uc002mpm.2_Silent_p.F618F|ILF3_uc002mpl.2_Silent_p.F614F|ILF3_uc002mpk.2_Silent_p.F614F|ILF3_uc010xli.1_Silent_p.F212F|ILF3_uc002mpo.2_Silent_p.F618F|ILF3_uc002mpp.2_Silent_p.F439F|ILF3_uc002mpq.2_5'Flank	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	614	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GACCGAAATTTGCTGCTAAGG	0.537		NA											75	118					0	0	0	0
RGL3	57139	broad.mit.edu	37	19	11510943	11510943	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:11510943T>C	uc002mrp.2	-	14	1579	c.1515A>G	c.(1513-1515)CCA>CCG	p.P505P	RGL3_uc002mrn.2_Silent_p.P269P|RGL3_uc002mrm.2_Silent_p.P269P|RGL3_uc002mro.2_Silent_p.P505P	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	505	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						AGGAGGCAGCTGGTGGCTCAA	0.612		NA											44	83					0	0	0	0
ZNF442	79973	broad.mit.edu	37	19	12461204	12461204	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:12461204G>A	uc002mtr.1	-	6	1806	c.1195C>T	c.(1195-1197)CAC>TAC	p.H399Y	ZNF442_uc010xmk.1_Missense_Mutation_p.H330Y	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	399	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						TCTCCAGTGTGCATTATCATA	0.428		NA											168	241					0	0	0	0
WIZ	58525	broad.mit.edu	37	19	15558935	15558935	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:15558935C>A	uc002nbb.3	-	2	398	c.184G>T	c.(184-186)GAT>TAT	p.D62Y	MIR1470_hsa-mir-1470|MI0007075_5'Flank	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						nucleus	zinc ion binding				0						CCTCTGCCATCCAGAATGTCT	0.627		NA											88	135					7.22e-40	1.05e-39	1	0
EPS15L1	58513	broad.mit.edu	37	19	16532206	16532206	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:16532206C>A	uc002ndz.1	-	10	880	c.874G>T	c.(874-876)GGC>TGC	p.G292C	EPS15L1_uc002ndx.2_Missense_Mutation_p.G292C|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.G182C|EPS15L1_uc010xpf.1_Missense_Mutation_p.G195C|EPS15L1_uc002nea.1_Missense_Mutation_p.G292C|EPS15L1_uc010eah.1_Missense_Mutation_p.G292C|EPS15L1_uc002neb.1_Missense_Mutation_p.G138C|EPS15L1_uc002nec.1_Missense_Mutation_p.G292C	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	292	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						CTCACGTAGCCATCCAGGTCC	0.537		NA											57	58					3.17e-14	3.88e-14	1	0
OCEL1	79629	broad.mit.edu	37	19	17337113	17337113	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:17337113G>C	uc002nfp.2	+	1	59	c.57G>C	c.(55-57)CAG>CAC	p.Q19H		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	19										central_nervous_system(1)	1						CGGAGCTCCAGACGCTGGGAC	0.692		NA											3	12					0	0	0	0
FCHO1	23149	broad.mit.edu	37	19	17886888	17886888	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:17886888G>T	uc010ebb.2	+	15	1289	c.1100G>T	c.(1099-1101)CGG>CTG	p.R367L	FCHO1_uc002nhg.3_Missense_Mutation_p.R367L|FCHO1_uc002nhh.2_Missense_Mutation_p.R367L|FCHO1_uc010xpw.1_Missense_Mutation_p.R317L|FCHO1_uc002nhi.2_5'Flank|FCHO1_uc002nhj.2_5'Flank	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	367										breast(1)	1						GCCCCGGCCCGGGCTCCAGCC	0.697		NA											56	63					8.77e-35	1.25e-34	1	0
ZNF253	56242	broad.mit.edu	37	19	20002455	20002455	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:20002455C>G	uc002noj.2	+	4	491	c.399C>G	c.(397-399)AAC>AAG	p.N133K	ZNF253_uc002nok.2_Missense_Mutation_p.N57K|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	133					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGGACTTAACCAATGTTTGA	0.323		NA											28	66					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21607279	21607279	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:21607279T>C	uc002npx.2	+	2	1714	c.1434T>C	c.(1432-1434)TGT>TGC	p.C478C	ZNF493_uc002npw.2_Silent_p.C606C|ZNF493_uc002npy.2_Silent_p.C478C	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	478	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGAAGAATGTGGCAAAGCTT	0.333		NA											25	39					0	0	0	0
DPY19L3	147991	broad.mit.edu	37	19	32973120	32973120	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:32973120G>T	uc002ntg.2	+	19	2301	c.2125G>T	c.(2125-2127)GTT>TTT	p.V709F	DPY19L3_uc002nth.1_Missense_Mutation_p.V709F|DPY19L3_uc002nti.1_RNA|DPY19L3_uc002ntj.1_Missense_Mutation_p.V131F	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	709						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					AACCTTCCACGTTTACAAGCT	0.458		NA											102	157					1.34e-64	2.04e-64	1	0
RHPN2	85415	broad.mit.edu	37	19	33482784	33482784	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:33482784A>T	uc002nuf.2	-	13	1655	c.1589T>A	c.(1588-1590)TTG>TAG	p.L530*	RHPN2_uc010xro.1_Nonsense_Mutation_p.L379*|RHPN2_uc002nue.2_Nonsense_Mutation_p.L260*	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	530	PDZ.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GTTCCCTCTCAAGGTGAACCC	0.537		NA											46	90					0	0	0	0
LRP3	4037	broad.mit.edu	37	19	33696633	33696633	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:33696633C>T	uc010edh.2	+	5	1050	c.957C>T	c.(955-957)GAC>GAT	p.D319D	LRP3_uc010xrp.1_Silent_p.D193D|LRP3_uc002nuk.3_Silent_p.D193D	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	319	Extracellular (Potential).|CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					AGCGCGGGGACCGCCTGCTGC	0.711		NA											6	11					0	0	0	0
CD22	933	broad.mit.edu	37	19	35828817	35828817	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:35828817C>T	uc010edt.2	+	5	955	c.878C>T	c.(877-879)ACG>ATG	p.T293M	CD22_uc010xst.1_Missense_Mutation_p.T121M|CD22_uc010edu.2_Missense_Mutation_p.T293M|CD22_uc010edv.2_Missense_Mutation_p.T293M|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	293	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding	p.T293T(1)		ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AATACATTCACGCTAAACCTG	0.562		NA											32	48					0	0	0	0
NPHS1	4868	broad.mit.edu	37	19	36341873	36341873	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:36341873G>A	uc002oby.2	-	4	516	c.516C>T	c.(514-516)ACC>ACT	p.T172T		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	172	Ig-like C2-type 2.|Extracellular (Potential).		Missing (in NPHS1).		cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCAGGAGAATGGTGATGTCAG	0.602		NA											21	28					0	0	0	0
ZNF566	84924	broad.mit.edu	37	19	36964331	36964331	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:36964331T>C	uc002oea.3	-	3	121	c.39A>G	c.(37-39)GTA>GTG	p.V13V	ZNF566_uc010xte.1_Silent_p.V13V|ZNF566_uc010xtf.1_Silent_p.V13V|ZNF566_uc002oeb.3_Silent_p.V13V|ZNF566_uc002oec.3_Intron|ZNF566_uc010xtg.1_Intron	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GAGAGAAGTCTACGGACACAT	0.388		NA											84	133					0	0	0	0
RYR1	6261	broad.mit.edu	37	19	38934789	38934789	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:38934789G>A	uc002oit.2	+	6	555	c.425G>A	c.(424-426)GGA>GAA	p.G142E	RYR1_uc002oiu.2_Missense_Mutation_p.G142E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	142	Cytoplasmic.|MIR 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCACCCATAGGAGAGGCTTGC	0.612		NA											20	34					0	0	0	0
CYP2B6	1555	broad.mit.edu	37	19	41515933	41515933	+	Missense_Mutation	SNP	A	A	T	rs146617126	byFrequency	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:41515933A>T	uc002opr.1	+	6	864	c.857A>T	c.(856-858)CAG>CTG	p.Q286L	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	286					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TTCAGCCACCAGAACCTCAAC	0.562		NA											43	62					0	0	0	0
DMRTC2	63946	broad.mit.edu	37	19	42352590	42352590	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:42352590C>A	uc002ors.2	+	4	524	c.441C>A	c.(439-441)CCC>CCA	p.P147P	DMRTC2_uc002orr.1_Missense_Mutation_p.P11Q|DMRTC2_uc010xwe.1_Silent_p.P147P	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	147	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						CGACACCCCCCGGGAAGGTAA	0.552		NA											6	22					8.13e-05	8.7e-05	1	0
ZNF578	147660	broad.mit.edu	37	19	53013842	53013843	+	Missense_Mutation	DNP	AT	AT	TG			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:53013842_53013843AT>TG	uc002pzp.3	+	6	452_453	c.208_209AT>TG	c.(208-210)ATG>TGG	p.M70W		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:Variant_position_missing_in_Q96N58_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TTCCAAACGCATGATGAAGGAG	0.371		NA											111	214					0	0	0	0
ZNF320	162967	broad.mit.edu	37	19	53384177	53384177	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:53384177G>A	uc002qag.2	-	4	1393	c.1202C>T	c.(1201-1203)GCA>GTA	p.A401V	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.A347V|ZNF320_uc002qai.2_Missense_Mutation_p.A401V	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TTGATGACATGCGAGGTACGC	0.388		NA											61	114					0	0	0	0
ZNF761	388561	broad.mit.edu	37	19	53959133	53959133	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:53959133A>G	uc010eqp.2	+	7	1830	c.1372A>G	c.(1372-1374)AGA>GGA	p.R458G	ZNF761_uc010ydy.1_Missense_Mutation_p.R404G|ZNF761_uc002qbt.1_Missense_Mutation_p.R404G	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	458	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ATGCCATCGTAGACGTCATAC	0.388		NA											76	104					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54314439	54314439	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:54314439G>T	uc002qch.3	-	3	694	c.474C>A	c.(472-474)ACC>ACA	p.T158T	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.T158T|NLRP12_uc002qcj.3_Silent_p.T158T|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.T158T	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	158					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GCAGGAGCCGGGTGTACCGGT	0.617		NA											93	128					8.65e-51	1.3e-50	1	0
NLRP2	55655	broad.mit.edu	37	19	55494535	55494535	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:55494535G>C	uc002qij.2	+	6	1555	c.1469G>C	c.(1468-1470)CGC>CCC	p.R490P	NLRP2_uc010yfp.1_Missense_Mutation_p.R467P|NLRP2_uc010esn.2_Missense_Mutation_p.R466P|NLRP2_uc010eso.2_Missense_Mutation_p.R487P|NLRP2_uc010esp.2_Missense_Mutation_p.R468P	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	490	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACATCCTCCGCCAGGACAGA	0.602		NA											49	77					0	0	0	0
NLRP5	126206	broad.mit.edu	37	19	56539566	56539566	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:56539566C>A	uc002qmj.2	+	7	1967	c.1967C>A	c.(1966-1968)CCC>CAC	p.P656H	NLRP5_uc002qmi.2_Missense_Mutation_p.P637H	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	656						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTGGGCTGTCCCGTTCCCCTG	0.597		NA											77	113					5.22e-30	7.26e-30	1	0
ZNF582	147948	broad.mit.edu	37	19	56895725	56895725	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:56895725A>G	uc002qmz.1	-	5	1220	c.1061T>C	c.(1060-1062)CTT>CCT	p.L354P	ZNF582_uc002qmy.2_Missense_Mutation_p.L385P	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	354	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		ATGTCGTATAAGAGTTGAGCC	0.418		NA											105	135					0	0	0	0
ZNF835	90485	broad.mit.edu	37	19	57176253	57176253	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:57176253C>A	uc010ygo.1	-	2	380	c.380G>T	c.(379-381)GGC>GTC	p.G127V	ZNF835_uc010ygn.1_Missense_Mutation_p.G105V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTTCTTGGGGCCTCCACCTCT	0.632		NA											26	43					7.01e-11	8.31e-11	1	0
ZNF548	147694	broad.mit.edu	37	19	57910559	57910559	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:57910559G>T	uc002qom.2	+	3	1154	c.904G>T	c.(904-906)GTT>TTT	p.V302F	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.V305F	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	302	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACATCAGAGAGTTCACACCGG	0.458		NA											38	65					4.63e-21	5.98e-21	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58549383	58549383	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:58549383G>C	uc002qrc.1	+	3	426	c.179G>C	c.(178-180)TGG>TCG	p.W60S	ZSCAN1_uc002qra.1_Missense_Mutation_p.W60S|ZSCAN1_uc002qrb.1_Missense_Mutation_p.W60S	NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	60	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCCAGCTCTGGACGCTGTGC	0.711		NA											8	7					0	0	0	0
ZNF497	162968	broad.mit.edu	37	19	58868799	58868799	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:58868799C>A	uc002qsh.1	-	3	392	c.203G>T	c.(202-204)GGA>GTA	p.G68V	A1BG_uc002qsf.1_Intron|ZNF497_uc002qsi.1_Missense_Mutation_p.G68V|uc002qsj.1_Missense_Mutation_p.S57Y|uc002qsk.1_5'Flank	NM_198458	NP_940860	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)		GCCGGGGCCTCCCTGTTCGTC	0.746		NA											6	11					0.000442599	0.000468102	1	0
NTSR2	23620	broad.mit.edu	37	2	11802345	11802345	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:11802345C>A	uc002rbq.3	-	2	720	c.646G>T	c.(646-648)GTG>TTG	p.V216L		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	216	Extracellular (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AAGGGGAGCACGAAGGACACC	0.647		NA											99	146					1.91e-35	2.73e-35	1	0
APOB	338	broad.mit.edu	37	2	21242655	21242655	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:21242655G>A	uc002red.2	-	19	3067	c.2939C>T	c.(2938-2940)GCT>GTT	p.A980V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	980					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTTGGAGTAAGCGCCTGAGGT	0.552		NA											32	33					0	0	0	0
CCDC85A	114800	broad.mit.edu	37	2	56602977	56602977	+	Silent	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:56602977T>A	uc002rzn.2	+	5	1981	c.1479T>A	c.(1477-1479)GCT>GCA	p.A493A		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	493										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CATCAGGGGCTGATGGGAGTA	0.408		NA											49	57					0	0	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71189914	71189914	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:71189914C>G	uc002shj.2	+	9	880	c.793C>G	c.(793-795)CGG>GGG	p.R265G	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.R265G|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.R223G	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	265					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CAGGATCGAGCGGATCATCAC	0.582		NA											35	83					0	0	0	0
PAIP2B	400961	broad.mit.edu	37	2	71429712	71429712	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:71429712C>A	uc002shu.2	-	2	195	c.8G>T	c.(7-9)GGA>GTA	p.G3V		NM_020459	NP_065192	Q9ULR5	PAI2B_HUMAN	poly(A) binding protein interacting protein 2B	3					negative regulation of translational initiation		protein binding|translation repressor activity, nucleic acid binding				0						CATATTGGATCCATTCATTAT	0.378		NA											78	87					1.25e-41	1.83e-41	1	0
REG1A	5967	broad.mit.edu	37	2	79348763	79348763	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:79348763G>T	uc002snz.2	+	3	243	c.140G>T	c.(139-141)TGC>TTC	p.C47F	REG1A_uc010ffx.1_Missense_Mutation_p.C47F|REG1A_uc010ysd.1_Missense_Mutation_p.C47F	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	47	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CGCTCCTACTGCTACTACTTT	0.542		NA											133	199					1.39e-51	2.09e-51	1	0
CTNNA2	1496	broad.mit.edu	37	2	80136777	80136777	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:80136777G>T	uc010ysh.1	+	6	915	c.910G>T	c.(910-912)GAG>TAG	p.E304*	CTNNA2_uc010yse.1_Nonsense_Mutation_p.E304*|CTNNA2_uc010ysf.1_Nonsense_Mutation_p.E304*|CTNNA2_uc010ysg.1_Nonsense_Mutation_p.E304*	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	304					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GCCGTCCCTGGAGGAGAGGCT	0.592		NA											60	107					5.41e-41	7.91e-41	1	0
TMEM150A	129303	broad.mit.edu	37	2	85829067	85829067	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:85829067G>T	uc002spw.1	-	1	726	c.5C>A	c.(4-6)ACC>AAC	p.T2N	USP39_uc002sqb.2_5'Flank|TMEM150A_uc002spx.1_5'UTR|TMEM150A_uc002spz.1_5'UTR|TMEM150A_uc002sqa.1_5'UTR|TMEM150A_uc002spy.1_Missense_Mutation_p.T2N	NM_001031738	NP_001026908	Q86TG1	T150A_HUMAN	transmembrane protein 150A isoform 1	2						integral to membrane|plasma membrane					0						GATCCAGGCGGTCATGAGGGA	0.612		NA											168	257					1.85e-90	2.84e-90	1	0
AFF3	3899	broad.mit.edu	37	2	100625330	100625330	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:100625330G>T	uc002tag.2	-	4	354	c.118C>A	c.(118-120)CAA>AAA	p.Q40K	AFF3_uc002taf.2_Missense_Mutation_p.Q65K|AFF3_uc010fiq.1_Missense_Mutation_p.Q40K|AFF3_uc010yvr.1_Missense_Mutation_p.Q194K|AFF3_uc002tah.1_Missense_Mutation_p.Q65K|AFF3_uc010fir.1_Missense_Mutation_p.Q117K|AFF3_uc002tai.2_5'Flank	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	40					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TCATCCTGTTGAGTTTCTTGA	0.403		NA											18	26					3.33e-07	3.73e-07	1	0
RGPD3	653489	broad.mit.edu	37	2	107042508	107042508	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:107042508G>T	uc010ywi.1	-	19	2699	c.2642C>A	c.(2641-2643)TCA>TAA	p.S881*		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	881					intracellular transport		binding			ovary(1)	1						ATATGCTGGTGACTGACTATA	0.308		NA											38	153					1.33e-27	1.82e-27	1	0
PCDP1	200373	broad.mit.edu	37	2	120413946	120413946	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:120413946A>G	uc002tmb.2	+	25	2657	c.1565A>G	c.(1564-1566)AAA>AGA	p.K522R		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	808						cilium	calmodulin binding				0	Colorectal(110;0.196)					AGAGAAGTGAAAGATCAAGCA	0.498		NA											30	47					0	0	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131797883	131797883	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:131797883A>T	uc002tsa.1	+	8	1494	c.974A>T	c.(973-975)CAG>CTG	p.Q325L	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Missense_Mutation_p.Q325L|ARHGEF4_uc010fmx.1_Intron|ARHGEF4_uc002tsc.1_5'UTR	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	325	DH.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		AGCGAGGAGCAGCTGCGTACC	0.667		NA											14	24					0	0	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135878405	135878405	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:135878405C>T	uc002tuj.2	+	8	690	c.665C>T	c.(664-666)CCA>CTA	p.P222L	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.P222L|RAB3GAP1_uc010fng.2_Missense_Mutation_p.P47L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	222						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CCTTTAACTCCATTGCCTCCA	0.378		NA											93	138					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141460022	141460022	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:141460022G>A	uc002tvj.1	-	38	7096	c.6124C>T	c.(6124-6126)CCG>TCG	p.P2042S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2042	Extracellular (Potential).|LDL-receptor class B 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGCCATTCGGCCATGCTATT	0.433		NA								TSP Lung(27;0.18)			49	111					0	0	0	0
ZEB2	9839	broad.mit.edu	37	2	145147422	145147422	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:145147422A>G	uc002tvu.2	-	10	3721	c.3241T>C	c.(3241-3243)TGC>CGC	p.C1081R	ZEB2_uc002tvv.2_Missense_Mutation_p.C1075R|ZEB2_uc010zbm.1_Missense_Mutation_p.C1052R|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1081						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCCCGCTTGCAGTAGGAATAC	0.602		NA											47	73					0	0	0	0
MBD5	55777	broad.mit.edu	37	2	149240960	149240960	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:149240960C>G	uc002twm.3	+	10	3788	c.2800C>G	c.(2800-2802)CTA>GTA	p.L934V	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.L934V|MBD5_uc002two.2_5'Flank|MBD5_uc002twp.2_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	934						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ACAGCATCTCCTAAACCAGAA	0.468		NA											116	219					0	0	0	0
TBR1	10716	broad.mit.edu	37	2	162273105	162273105	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:162273105C>G	uc002ubw.1	+	1	486	c.184C>G	c.(184-186)CAG>GAG	p.Q62E	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GATGACGAATCAGTCAGATAC	0.493		NA											66	91					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170062967	170062967	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:170062967G>A	uc002ues.2	-	39	7476	c.7263C>T	c.(7261-7263)GTC>GTT	p.V2421V		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2421	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTAGAGACATGACAGTTCTTT	0.413		NA											71	96					0	0	0	0
HOXD8	3234	broad.mit.edu	37	2	176995440	176995440	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:176995440C>A	uc002uko.2	+	1	964	c.346C>A	c.(346-348)CCG>ACG	p.P116T	uc002ukl.1_5'Flank|uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Intron|HOXD8_uc002ukp.2_Missense_Mutation_p.P116T	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	116	Poly-Pro.				anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		tccgcatcctccgcctccgcc	0.507		NA											77	90					2.36e-25	3.19e-25	1	0
TTN	7273	broad.mit.edu	37	2	179427269	179427269	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:179427269G>A	uc010zfg.1	-	275	76110	c.75886C>T	c.(75886-75888)CCC>TCC	p.P25296S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P18991S|TTN_uc010zfi.1_Missense_Mutation_p.P18924S|TTN_uc010zfj.1_Missense_Mutation_p.P18799S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26223							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGGAGGGGTGGTTCAGAC	0.448		NA											52	76					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179470333	179470333	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:179470333A>G	uc010zfg.1	-	228	46209	c.45985T>C	c.(45985-45987)TAT>CAT	p.Y15329H	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y9024H|TTN_uc010zfi.1_Missense_Mutation_p.Y8957H|TTN_uc010zfj.1_Missense_Mutation_p.Y8832H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16256							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAATGATATATCCTTGGATG	0.443		NA											76	133					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179583155	179583155	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:179583155G>T	uc010zfg.1	-	82	21170	c.20946C>A	c.(20944-20946)ACC>ACA	p.T6982T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T3643T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7909							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCAGTATGGTAGATTTTT	0.418		NA											49	62					2.13e-23	2.84e-23	1	0
C2orf88	84281	broad.mit.edu	37	2	191064816	191064816	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:191064816G>A	uc002urq.2	+	3	609	c.230G>A	c.(229-231)TGG>TAG	p.W77*	C2orf88_uc002urr.2_Nonsense_Mutation_p.W77*|C2orf88_uc002urs.2_Nonsense_Mutation_p.W77*|C2orf88_uc002urt.2_Nonsense_Mutation_p.W77*	NM_001042521	NP_001035986	Q9BSF0	CB088_HUMAN	hypothetical protein LOC84281	77											0						TTGCAGCAATGGGCATGCAAT	0.473		NA											130	204					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196659124	196659124	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:196659124T>A	uc002utj.3	-	57	10755	c.10654A>T	c.(10654-10656)ATT>TTT	p.I3552F	DNAH7_uc002uti.3_Missense_Mutation_p.I35F	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3552	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TATGATCGAATGATATTAGCC	0.453		NA											71	95					0	0	0	0
MOBKL3	25843	broad.mit.edu	37	2	198413136	198413136	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:198413136G>T	uc002uun.3	+	6	471	c.431G>T	c.(430-432)AGC>ATC	p.S144I	MOBKL3_uc002uum.3_Missense_Mutation_p.S112I|MOBKL3_uc010fsn.2_Missense_Mutation_p.S123I|MOBKL3_uc010fso.2_Missense_Mutation_p.S45I|MOBKL3_uc010zgz.1_Missense_Mutation_p.S45I	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	144					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)			TATTTTCCCAGCAGGTAATCG	0.249		NA											49	78					2.82e-22	3.7e-22	1	0
ERBB4	2066	broad.mit.edu	37	2	212288906	212288906	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:212288906A>G	uc002veg.1	-	23	2938	c.2840T>C	c.(2839-2841)ATT>ACT	p.I947T	ERBB4_uc002veh.1_Missense_Mutation_p.I947T|ERBB4_uc010zji.1_Missense_Mutation_p.I937T|ERBB4_uc010zjj.1_Missense_Mutation_p.I937T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	947	Protein kinase.|Cytoplasmic (Potential).			I->R: Constitutively autophosphorylated.	cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTAAACGTCAATAGTGCAGAT	0.388		NA								TSP Lung(8;0.080)			70	105					0	0	0	0
CTDSP1	58190	broad.mit.edu	37	2	219267845	219267845	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:219267845G>A	uc002vhy.2	+	5	802	c.466G>A	c.(466-468)GCC>ACC	p.A156T	CTDSP1_uc002vhx.2_Missense_Mutation_p.A155T|CTDSP1_uc002vhz.2_Missense_Mutation_p.A15T	NM_021198	NP_067021	Q9GZU7	CTDS1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	156	FCP1 homology.				protein dephosphorylation|regulation of transcription from RNA polymerase II promoter	nucleus	CTD phosphatase activity|metal ion binding|protein binding			ovary(1)	1		Renal(207;0.0915)		Epithelial(149;9.96e-07)|all cancers(144;0.00017)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTAGCCTCGCCAAGGTGAG	0.642		NA											51	73					0	0	0	0
WDFY1	57590	broad.mit.edu	37	2	224765920	224765920	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:224765920C>T	uc002vnq.2	-	5	516	c.465G>A	c.(463-465)ACG>ACA	p.T155T		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	155	WD 4.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		AAGCCCAGGACGTGAAGAAGT	0.577		NA											50	75					0	0	0	0
DOCK10	55619	broad.mit.edu	37	2	225659685	225659685	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:225659685C>T	uc010fwz.1	-	45	5304	c.5065G>A	c.(5065-5067)GCA>ACA	p.A1689T	DOCK10_uc002vob.2_Missense_Mutation_p.A1683T|DOCK10_uc002voa.2_Missense_Mutation_p.A345T|DOCK10_uc002voc.2_Missense_Mutation_p.A543T	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1689	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TAGGAGTTTGCCAGGCTGTAC	0.517		NA											5	275					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	227985813	227985813	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:227985813G>A	uc010zlt.1	-	5	898	c.244C>T	c.(244-246)CCA>TCA	p.P82S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	82	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATGGGTCCTGGGGCTCCCAGG	0.542		NA											59	72					0	0	0	0
DIS3L2	129563	broad.mit.edu	37	2	233198642	233198642	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:233198642G>A	uc010fxz.2	+	17	2379	c.2103G>A	c.(2101-2103)TCG>TCA	p.S701S	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_5'Flank	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	701							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		ACTTCACCTCGCCCATCCGCC	0.667		NA											58	97					0	0	0	0
CHRND	1144	broad.mit.edu	37	2	233394727	233394727	+	Missense_Mutation	SNP	G	G	T	rs146416320		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:233394727G>T	uc002vsw.2	+	7	702	c.698G>T	c.(697-699)CGC>CTC	p.R233L	CHRND_uc010zmg.1_Missense_Mutation_p.R218L|CHRND_uc010fyc.2_Missense_Mutation_p.R106L|CHRND_uc010zmh.1_Intron	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	233	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		AGCCCCAGCCGCCAGGACATC	0.617		NA											56	103					4.33e-36	6.22e-36	1	0
NGEF	25791	broad.mit.edu	37	2	233839522	233839522	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:233839522G>T	uc002vts.2	-	2	327	c.79C>A	c.(79-81)CCA>ACA	p.P27T		NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	27	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		ACCTTGGCTGGTTCATTATCA	0.443		NA											81	125					1.52e-23	2.03e-23	1	0
TRPM8	79054	broad.mit.edu	37	2	234904971	234904971	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:234904971T>G	uc002vvh.2	+	22	2981	c.2941T>G	c.(2941-2943)TAC>GAC	p.Y981D	TRPM8_uc010fyj.2_Missense_Mutation_p.Y559D|TRPM8_uc010fyk.2_RNA	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	981	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CCTCACCAGCTACACGGTGGG	0.512		NA											45	74					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238275541	238275541	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:238275541G>T	uc002vwl.2	-	11	5574	c.5289C>A	c.(5287-5289)AGC>AGA	p.S1763R	COL6A3_uc002vwo.2_Missense_Mutation_p.S1557R|COL6A3_uc010znj.1_Missense_Mutation_p.S1156R	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1763	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGAGGGCCAGGCTCACATCCT	0.582		NA											48	56					2.43e-25	3.28e-25	1	0
COL6A3	1293	broad.mit.edu	37	2	238283363	238283363	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:238283363G>C	uc002vwl.2	-	8	3656	c.3371C>G	c.(3370-3372)GCG>GGG	p.A1124G	COL6A3_uc002vwo.2_Missense_Mutation_p.A918G|COL6A3_uc010znj.1_Missense_Mutation_p.A517G|COL6A3_uc002vwq.2_Missense_Mutation_p.A918G|COL6A3_uc002vwr.2_Missense_Mutation_p.A717G	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1124	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCTGCTTCCCGCAGAGCTGAC	0.647		NA											45	68					0	0	0	0
CAPN10	11132	broad.mit.edu	37	2	241533429	241533429	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:241533429G>T	uc002vzk.1	+	5	979	c.795G>T	c.(793-795)TGG>TGT	p.W265C	CAPN10_uc010zoh.1_Missense_Mutation_p.W265C|CAPN10_uc002vzl.1_Missense_Mutation_p.W265C|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.W137C|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	265	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGAACCCCTGGGGCCGGCGGT	0.692		NA											86	106					1.43e-44	2.11e-44	1	0
ANGPT4	51378	broad.mit.edu	37	20	870932	870932	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:870932G>C	uc002wei.2	-	2	492	c.389C>G	c.(388-390)CCC>CGC	p.P130R	ANGPT4_uc010zpn.1_Missense_Mutation_p.P124R	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	130	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						CTCTAGCATGGGGGCCGTCTG	0.607		NA											67	125					0	0	0	0
KIF16B	55614	broad.mit.edu	37	20	16486697	16486697	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:16486697C>A	uc002wpg.1	-	8	996	c.838G>T	c.(838-840)GTG>TTG	p.V280L	KIF16B_uc010gch.1_Missense_Mutation_p.V280L|KIF16B_uc010gci.1_Missense_Mutation_p.V280L|KIF16B_uc010gcj.1_Missense_Mutation_p.V280L	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	280	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CCCAGAGTCACGAGGGACTTG	0.512		NA											80	377					9.59e-39	1.39e-38	1	0
C20orf26	26074	broad.mit.edu	37	20	20177362	20177362	+	Missense_Mutation	SNP	G	G	T	rs115927004	by1000genomes	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:20177362G>T	uc002wru.2	+	16	1815	c.1739G>T	c.(1738-1740)CGT>CTT	p.R580L	C20orf26_uc010zse.1_Missense_Mutation_p.R560L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	580										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GAGATCCTGCGTTTAGGCTTT	0.483		NA											120	187					5.01e-73	7.68e-73	1	0
NKX2-4	644524	broad.mit.edu	37	20	21376612	21376612	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:21376612C>T	uc010gcz.2	-	2	1012	c.1002G>A	c.(1000-1002)GCG>GCA	p.A334A		NM_033176	NP_149416	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	334					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ccccggcggccgcgtccaggg	0.577		NA											17	11					0	0	0	0
PAX1	5075	broad.mit.edu	37	20	21687579	21687579	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:21687579G>T	uc002wsj.2	+	2	844	c.790G>T	c.(790-792)GGC>TGC	p.G264C	PAX1_uc010zsl.1_Missense_Mutation_p.G264C|PAX1_uc010zsm.1_Missense_Mutation_p.G240C	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	264					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GTCGCCCACGGGCGCCAAGAT	0.697		NA											47	43					1.65e-34	2.36e-34	1	0
SSTR4	6754	broad.mit.edu	37	20	23016732	23016732	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:23016732C>A	uc002wsr.2	+	1	676	c.612C>A	c.(610-612)CAC>CAA	p.H204Q		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	204	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					AGTGGCCACACCCGGCCTGGT	0.657		NA											37	107					1.01e-15	1.25e-15	1	0
GGTLC1	92086	broad.mit.edu	37	20	23966370	23966370	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:23966370C>T	uc002wts.2	-	5	598	c.465G>A	c.(463-465)GTG>GTA	p.V155V	GGTLC1_uc002wtu.2_Silent_p.V155V	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	155							gamma-glutamyltransferase activity			ovary(1)	1						GGGGCTCCTCCACGGCCCACT	0.607		NA											161	125					0	0	0	0
CEP250	11190	broad.mit.edu	37	20	34092279	34092279	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:34092279G>A	uc002xcm.2	+	31	6753	c.6082G>A	c.(6082-6084)GAC>AAC	p.D2028N	CEP250_uc010zve.1_Missense_Mutation_p.D1396N	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	2028	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TGAGATCCAGGACCAGGATCT	0.607		NA											6	26					0	0	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060934	35060934	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:35060934G>A	uc002xff.2	+	3	1249	c.814G>A	c.(814-816)GCA>ACA	p.A272T	DLGAP4_uc010zvp.1_Missense_Mutation_p.A272T	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	272	Poly-Pro.				cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ACCCCCGCCCGCACCCCCAGC	0.627		NA											10	19					0	0	0	0
TGM2	7052	broad.mit.edu	37	20	36775222	36775222	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:36775222C>A	uc002xhr.2	-	6	856	c.756G>T	c.(754-756)ATG>ATT	p.M252I	TGM2_uc010zvx.1_Missense_Mutation_p.M171I|TGM2_uc010zvy.1_Missense_Mutation_p.M192I|TGM2_uc002xhs.1_Missense_Mutation_p.M228I|TGM2_uc002xht.2_Missense_Mutation_p.M252I|TGM2_uc002xhu.3_Missense_Mutation_p.M252I	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	252					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CGATCCAGGACATGGGGCTGA	0.657		NA											75	62					1.35e-34	1.93e-34	1	0
ACTR5	79913	broad.mit.edu	37	20	37395021	37395021	+	Splice_Site	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:37395021G>A	uc002xjd.2	+	7	1458	c.1433_splice	c.e7+1	p.R478_splice		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog						DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				TTCTGGACAGGTGAGACAGCG	0.433		NA											362	140					0	0	0	0
YTHDF1	54915	broad.mit.edu	37	20	61833966	61833966	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:61833966C>A	uc002yeh.2	-	4	1620	c.1326G>T	c.(1324-1326)GGG>GGT	p.G442G	YTHDF1_uc011aaq.1_Silent_p.G392G	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	442	YTH.									ovary(2)	2						AATGCCCACTCCCATTGACGC	0.607		NA											80	36					5.37e-22	7.01e-22	1	0
BAGE2	85319	broad.mit.edu	37	21	11058319	11058319	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr21:11058319C>T	uc002yit.1	-	3	329	c.121G>A	c.(121-123)GTG>ATG	p.V41M	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACAAAATGCACATCGCTGAAA	0.388		NA											25	253					0	0	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032693	46032693	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr21:46032693C>T	uc002zfo.1	+	1	698	c.676C>T	c.(676-678)CCC>TCC	p.P226S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	226	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|breast(1)	2						tgtgcctgtcccctcctgttg	0.204		NA											62	73					0	0	0	0
USP18	11274	broad.mit.edu	37	22	18643000	18643000	+	Missense_Mutation	SNP	C	C	A	rs138144879	byFrequency	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr22:18643000C>A	uc002zny.2	+	3	557	c.219C>A	c.(217-219)TTC>TTA	p.F73L		NM_017414	NP_059110	Q9UMW8	UBP18_HUMAN	ubiquitin specific protease 18	73					regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway|ubiquitin-dependent protein catabolic process	cytosol|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)	1						TTCAGGTGTTCGTAATGAATG	0.373		NA											260	31					2.6e-106	3.99e-106	1	0
APOL3	80833	broad.mit.edu	37	22	36541544	36541544	+	Silent	SNP	G	G	A	rs61731691		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr22:36541544G>A	uc003aot.2	-	2	365	c.327C>T	c.(325-327)TTC>TTT	p.F109F	APOL3_uc003aoq.2_Silent_p.F38F|APOL3_uc003aor.2_Silent_p.F38F|APOL3_uc003aos.2_Silent_p.F38F|APOL3_uc003aou.2_5'UTR|APOL3_uc003aov.2_5'UTR	NM_145640	NP_663615	O95236	APOL3_HUMAN	apolipoprotein L3 isoform 1	109					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity				0						CCGCAGTCACGAATCTCTTCC	0.552		NA											50	105					0	0	0	0
LRRN1	57633	broad.mit.edu	37	3	3886403	3886403	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:3886403C>A	uc003bpt.3	+	2	839	c.78C>A	c.(76-78)TCC>TCA	p.S26S	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	26	LRRNT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCGAGTCTTCCATACAGAATA	0.463		NA											59	19					4.1e-35	5.86e-35	1	0
PLCL2	23228	broad.mit.edu	37	3	17056221	17056221	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:17056221G>A	uc011awc.1	+	6	2917	c.2812G>A	c.(2812-2814)GAG>AAG	p.E938K	PLCL2_uc011awd.1_Missense_Mutation_p.E820K	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	946					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GTCATTCAAGGAGCTGTGTGG	0.463		NA											173	43					0	0	0	0
EOMES	8320	broad.mit.edu	37	3	27763724	27763724	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:27763724G>T	uc003cdx.2	-	1	62	c.62C>A	c.(61-63)CCG>CAG	p.P21Q	EOMES_uc003cdy.3_Missense_Mutation_p.P21Q|EOMES_uc010hfn.2_Missense_Mutation_p.P21Q|EOMES_uc011axc.1_Intron	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	21					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						ACTCTCCAGCGGGTAGAAGTG	0.642		NA											6	2					0.00198382	0.00206833	1	0
LAMB2	3913	broad.mit.edu	37	3	49161040	49161040	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:49161040C>T	uc003cwe.2	-	25	4121	c.3822G>A	c.(3820-3822)GAG>GAA	p.E1274E	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1274	Domain II.|Potential.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGTCAGGTGCTCAGTGGCCT	0.557		NA											69	25					0	0	0	0
AMIGO3	386724	broad.mit.edu	37	3	49755619	49755619	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:49755619T>G	uc003cxj.2	-	1	1620	c.1280A>C	c.(1279-1281)CAA>CCA	p.Q427P	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	427	Cytoplasmic (Potential).				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTCAGCTCTTGGAGCGGGCT	0.522		NA											74	27					0	0	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50421637	50421637	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:50421637G>A	uc003daq.2	-	6	680	c.642C>T	c.(640-642)ATC>ATT	p.I214I	CACNA2D2_uc003dap.2_Silent_p.I214I	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	214	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	AGCCTTTGTAGATGTCCGTAG	0.567		NA											219	70					0	0	0	0
FOXP1	27086	broad.mit.edu	37	3	71247394	71247394	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:71247394C>A	uc003dol.2	-	2	462	c.139G>T	c.(139-141)GGG>TGG	p.G47W	FOXP1_uc003dom.2_Missense_Mutation_p.G47W|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.G47W|FOXP1_uc003dop.2_Missense_Mutation_p.G47W|FOXP1_uc003doq.1_Missense_Mutation_p.G47W|FOXP1_uc003dos.2_Missense_Mutation_p.G47W	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	47					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TCAGCTGCCCCGATGTCCACG	0.627		NA	T	PAX5	ALL								85	38					5e-47	7.46e-47	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433465	73433465	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:73433465T>C	uc003dpl.1	-	10	2348	c.2252A>G	c.(2251-2253)GAC>GGC	p.D751G	PDZRN3_uc011bgh.1_Missense_Mutation_p.D408G|PDZRN3_uc010hoe.1_Missense_Mutation_p.D449G|PDZRN3_uc011bgf.1_Missense_Mutation_p.D468G|PDZRN3_uc011bgg.1_Missense_Mutation_p.D471G	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	751							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCTGTCCTTGTCGGATTTCTC	0.617		NA											26	12					0	0	0	0
ROBO2	6092	broad.mit.edu	37	3	77666777	77666777	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:77666777G>A	uc003dpy.3	+	22	4050	c.3407G>A	c.(3406-3408)GGC>GAC	p.G1136D	ROBO2_uc003dpz.2_Missense_Mutation_p.G1140D|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.G1140D|ROBO2_uc003dqa.2_Missense_Mutation_p.G263D	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1136	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CCTGTTCGAGGCGTGGCTTCT	0.527		NA											85	21					0	0	0	0
EPHA3	2042	broad.mit.edu	37	3	89521722	89521722	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:89521722G>T	uc003dqy.2	+	16	3024	c.2799G>T	c.(2797-2799)ACG>ACT	p.T933T	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	933	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AAATCTTCACGGGTGTGGAGT	0.413		NA								TSP Lung(6;0.00050)			60	28					1.32e-49	1.98e-49	1	0
NSUN3	63899	broad.mit.edu	37	3	93783304	93783304	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:93783304G>T	uc003drl.1	+	2	152	c.36G>T	c.(34-36)AAG>AAT	p.K12N	DHFRL1_uc003dri.2_5'Flank|DHFRL1_uc003drj.2_5'Flank	NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	12							methyltransferase activity			skin(1)	1						CAGAGGGGAAGCTTGCAAAAC	0.358		NA											30	105					2.82e-10	3.31e-10	1	0
NSUN3	63899	broad.mit.edu	37	3	93783306	93783306	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:93783306T>A	uc003drl.1	+	2	154	c.38T>A	c.(37-39)CTT>CAT	p.L13H	DHFRL1_uc003dri.2_5'Flank|DHFRL1_uc003drj.2_5'Flank	NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	13							methyltransferase activity			skin(1)	1						GAGGGGAAGCTTGCAAAACAG	0.363		NA											30	104					0	0	0	0
EPHA6	285220	broad.mit.edu	37	3	96706794	96706794	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:96706794C>T	uc010how.1	+	3	1114	c.1071C>T	c.(1069-1071)TGC>TGT	p.C357C	EPHA6_uc003drp.1_Silent_p.C357C	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	262	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TTGGAAGGTGCATCTGCAGTA	0.383		NA											57	207					0	0	0	0
FILIP1L	11259	broad.mit.edu	37	3	99567165	99567165	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:99567165G>A	uc003dtm.2	-	5	3818	c.3355C>T	c.(3355-3357)CCT>TCT	p.P1119S	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.P1119S|FILIP1L_uc010hpf.2_Missense_Mutation_p.P695S|FILIP1L_uc010hpg.2_Missense_Mutation_p.P879S|FILIP1L_uc003dtn.2_Missense_Mutation_p.P879S|FILIP1L_uc003dtp.1_Missense_Mutation_p.P879S	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	1119						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						CGAGGAAGAGGTGTGGCTGTT	0.413		NA											75	258					0	0	0	0
GPR128	84873	broad.mit.edu	37	3	100349615	100349615	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:100349615G>T	uc003duc.2	+	3	564	c.296G>T	c.(295-297)GGA>GTA	p.G99V		NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	99	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GGCAGATATGGACCATCCTTG	0.348		NA											88	107					5.34e-38	7.71e-38	1	0
GPR128	84873	broad.mit.edu	37	3	100373869	100373869	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:100373869C>A	uc003duc.2	+	12	1838	c.1570C>A	c.(1570-1572)CCC>ACC	p.P524T	GPR128_uc011bhc.1_Missense_Mutation_p.P225T|GPR128_uc003dud.2_Missense_Mutation_p.P47T	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	524	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						CATCCCGAATCCCATGTGCAC	0.423		NA											286	380					2.3e-82	3.52e-82	1	0
CEP97	79598	broad.mit.edu	37	3	101477063	101477063	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:101477063C>G	uc003dvk.1	+	9	1640	c.1613C>G	c.(1612-1614)CCC>CGC	p.P538R	CEP97_uc010hpm.1_Missense_Mutation_p.P504R|CEP97_uc011bhf.1_Missense_Mutation_p.P479R|CEP97_uc003dvl.1_Missense_Mutation_p.P234R|CEP97_uc003dvm.1_Missense_Mutation_p.P376R	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	538	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						GAGAAACTTCCCATGATTTTA	0.418		NA											90	349					0	0	0	0
MYH15	22989	broad.mit.edu	37	3	108159997	108159997	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:108159997C>T	uc003dxa.1	-	24	2883	c.2826G>A	c.(2824-2826)GAG>GAA	p.E942E		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	942	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AATTTATCTCCTCTTCTTCCT	0.478		NA											83	256					0	0	0	0
PLSCR5	389158	broad.mit.edu	37	3	146309588	146309588	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:146309588G>T	uc003ewb.2	-	5	1538	c.534C>A	c.(532-534)ATC>ATA	p.I178I	PLSCR5_uc010hvb.2_Silent_p.I166I|PLSCR5_uc010hvc.2_Silent_p.I178I	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	178											0						TTGCATTTTGGATTGTGAATT	0.388		NA											61	26					2.23e-26	3.03e-26	1	0
ZIC1	7545	broad.mit.edu	37	3	147128064	147128064	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:147128064G>C	uc003ewe.2	+	1	884	c.165G>C	c.(163-165)GAG>GAC	p.E55D		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	55					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTTCGCACGAGCTGGCTTCGG	0.711		NA											89	50					0	0	0	0
FAM194A	131831	broad.mit.edu	37	3	150400034	150400034	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:150400034C>A	uc003eyg.2	-	7	910	c.853G>T	c.(853-855)GTG>TTG	p.V285L	FAM194A_uc003eyh.2_Missense_Mutation_p.V139L	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	285										skin(2)|ovary(1)	3						GAAACATCCACATTAGAAAAA	0.358		NA											88	123					2.01e-38	2.92e-38	1	0
GPR149	344758	broad.mit.edu	37	3	154146445	154146445	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:154146445G>T	uc003faa.2	-	1	1060	c.960C>A	c.(958-960)GTC>GTA	p.V320V		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	320	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCCAAAGGACGACTTTTGTAA	0.567		NA											229	311					4.77e-124	7.34e-124	1	0
SI	6476	broad.mit.edu	37	3	164786619	164786619	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:164786619C>G	uc003fei.2	-	5	436	c.374G>C	c.(373-375)GGA>GCA	p.G125A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	125	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGCTTCAACTCCTTAAAGAAT	0.303		NA								HNSCC(35;0.089)			5	253					0	0	0	0
PDCD10	11235	broad.mit.edu	37	3	167437849	167437849	+	Splice_Site	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:167437849C>T	uc003fex.2	-	3	494	c.96_splice	c.e3+1	p.E32_splice	PDCD10_uc003fez.2_Splice_Site_p.E32_splice|PDCD10_uc003fey.2_Splice_Site_p.E32_splice	NM_007217	NP_009148	Q9BUL8	PDC10_HUMAN	programmed cell death 10						angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			lung(1)|central_nervous_system(1)	2						ACCCAACTCACCTCATTAAAC	0.343		NA							Familial_Cerebral_Cavernous_Angioma				57	208					0	0	0	0
USP13	8975	broad.mit.edu	37	3	179472519	179472519	+	Splice_Site	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:179472519G>T	uc003fkh.2	+	15	1880	c.1799_splice	c.e15-1	p.D600_splice	USP13_uc003fkf.2_Intron	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13						ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TCATTTTGCAGATGTTTCTAT	0.448		NA											89	293					1.54e-61	2.35e-61	1	0
VPS8	23355	broad.mit.edu	37	3	184675175	184675175	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:184675175G>T	uc003fpb.1	+	36	3214	c.3043G>T	c.(3043-3045)GTA>TTA	p.V1015L	VPS8_uc010hyd.1_Missense_Mutation_p.V925L|VPS8_uc010hye.1_Missense_Mutation_p.V444L	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1017							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AGGTATTCATGTAAATCAAGA	0.333		NA											9	60					3.1e-07	3.48e-07	1	0
CCDC50	152137	broad.mit.edu	37	3	191078925	191078925	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:191078925C>T	uc003fsw.2	+	4	897	c.307C>T	c.(307-309)CGC>TGC	p.R103C	CCDC50_uc003fsv.2_Missense_Mutation_p.R103C	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	103	Potential.					cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		AGAGAGACGACGCATTCAGGA	0.433		NA											31	171					0	0	0	0
CPN2	1370	broad.mit.edu	37	3	194063363	194063363	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:194063363G>T	uc003fts.2	-	2	159	c.69C>A	c.(67-69)CCC>CCA	p.P23P		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	23	LRRNT.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CACAACCCATGGGACAGGGCT	0.582		NA											237	88					6.36e-115	9.78e-115	1	0
MUC4	4585	broad.mit.edu	37	3	195505813	195505814	+	Missense_Mutation	DNP	TC	TC	CT			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:195505813_195505814TC>CT	uc011bto.1	-	3	12713_12714	c.12253_12254GA>AG	c.(12253-12255)GAC>AGC	p.D4085S	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGAGGAAGTGTCGGTGACAGGA	0.594		NA											4	26					0	0	0	0
UBXN7	26043	broad.mit.edu	37	3	196098827	196098827	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:196098827G>A	uc003fwm.3	-	6	630	c.555C>T	c.(553-555)CGC>CGT	p.R185R	UBXN7_uc003fwn.3_Silent_p.R37R|UBXN7_uc010iae.2_Silent_p.R23R	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	185							protein binding			ovary(2)|pancreas(1)	3						TCCACACATCGCGGTTGAGGC	0.413		NA											91	333					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20543121	20543121	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:20543121G>T	uc003gpr.1	+	20	2226	c.2022G>T	c.(2020-2022)TGG>TGT	p.W674C	SLIT2_uc003gps.1_Missense_Mutation_p.W666C	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	674	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACCTGGCTTGGTTGGGAGAGT	0.458		NA											46	11					1.11e-35	1.59e-35	1	0
SLIT2	9353	broad.mit.edu	37	4	20555507	20555507	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:20555507C>T	uc003gpr.1	+	26	2845	c.2641C>T	c.(2641-2643)CCT>TCT	p.P881S	SLIT2_uc003gps.1_Missense_Mutation_p.P873S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	881	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATATAAGGAGCCTGGAATTGC	0.428		NA											98	12					0	0	0	0
GABRA2	2555	broad.mit.edu	37	4	46252334	46252334	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:46252334G>A	uc003gxc.3	-	9	2020	c.1347C>T	c.(1345-1347)GTC>GTT	p.V449V	GABRA2_uc010igc.2_Silent_p.V449V|GABRA2_uc011bzc.1_Silent_p.V454V	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	449					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCAAGGACTGACCCCTAATA	0.338		NA											70	23					0	0	0	0
GABRA4	2557	broad.mit.edu	37	4	46930523	46930523	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:46930523C>G	uc003gxg.2	-	9	1523	c.1384G>C	c.(1384-1386)GGA>CGA	p.G462R		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	462	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGCATATATCCAGTTCGGATA	0.473		NA											68	18					0	0	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978432	69978432	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:69978432C>A	uc003heg.3	+	6	1614	c.1568C>A	c.(1567-1569)GCA>GAA	p.A523E	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	523					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GCTAGAAAAGCAAAGAAGGGA	0.378		NA											48	25					1.67e-32	2.35e-32	1	0
UGT2B4	7363	broad.mit.edu	37	4	70352383	70352383	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:70352383T>A	uc003hek.3	-	4	1081	c.1034A>T	c.(1033-1035)GAT>GTT	p.D345V	UGT2B4_uc011cap.1_Missense_Mutation_p.D209V|UGT2B4_uc003hel.3_Missense_Mutation_p.D345V	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	345					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TCCTAAAGTATCTGGTTTATT	0.348		NA											102	40					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123207877	123207877	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:123207877A>G	uc003ieh.2	+	51	9264	c.9219A>G	c.(9217-9219)ATA>ATG	p.I3073M	KIAA1109_uc003iel.1_Missense_Mutation_p.I1008M	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3073					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGTGGAGTATAGATGAACTGC	0.378		NA											66	23					0	0	0	0
SPATA5	166378	broad.mit.edu	37	4	123868598	123868598	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:123868598C>T	uc003iez.3	+	9	1742	c.1669C>T	c.(1669-1671)CAT>TAT	p.H557Y	SPATA5_uc003iey.2_Missense_Mutation_p.H556Y	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	557					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						AAATAGTGCTCATGGATACGT	0.478		NA											70	26					0	0	0	0
FGA	2243	broad.mit.edu	37	4	155507095	155507095	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:155507095C>A	uc003iod.1	-	5	1544	c.1486G>T	c.(1486-1488)GAT>TAT	p.D496Y	FGA_uc003ioe.1_Missense_Mutation_p.D496Y|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	496	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GTGCCTAAATCCATTGCCTCG	0.473		NA											87	33					9.37e-40	1.36e-39	1	0
GUCY1A3	2982	broad.mit.edu	37	4	156632328	156632328	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:156632328G>T	uc003iov.2	+	7	1547	c.1011G>T	c.(1009-1011)GGG>GGT	p.G337G	GUCY1A3_uc003iou.2_Silent_p.G337G|GUCY1A3_uc010iqc.2_Silent_p.G337G|GUCY1A3_uc003iow.2_Silent_p.G337G|GUCY1A3_uc010iqd.2_Silent_p.G336G|GUCY1A3_uc003iox.2_Silent_p.G337G|GUCY1A3_uc003ioz.2_Silent_p.G102G|GUCY1A3_uc003ioy.2_Silent_p.G337G|GUCY1A3_uc010iqe.2_Silent_p.G102G|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.G337G	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	337					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CGTTTAGCGGGATCATGACTA	0.383		NA											73	30					2.93e-43	4.32e-43	1	0
ACCN5	51802	broad.mit.edu	37	4	156752976	156752976	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:156752976C>A	uc003ipe.1	-	9	1374	c.1327G>T	c.(1327-1329)GCA>TCA	p.A443S		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	443	Extracellular (Potential).			A->F,T: Activates the channel.|A->C: Slightly activates the channel.		integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		TAACACTTACCAAGTAACTCA	0.224		NA											54	26					2.7e-35	3.86e-35	1	0
ACCN5	51802	broad.mit.edu	37	4	156764923	156764923	+	Missense_Mutation	SNP	G	G	C	rs145138118	by1000genomes	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:156764923G>C	uc003ipe.1	-	5	818	c.771C>G	c.(769-771)ATC>ATG	p.I257M		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	257	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		TTGGTGAATGGATAACAAAGA	0.443		NA											43	19					0	0	0	0
GRIA2	2891	broad.mit.edu	37	4	158262467	158262467	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:158262467C>T	uc003ipm.3	+	12	2355	c.1896C>T	c.(1894-1896)ATC>ATT	p.I632I	GRIA2_uc011cit.1_Silent_p.I585I|GRIA2_uc003ipl.3_Silent_p.I632I|GRIA2_uc003ipk.3_Silent_p.I585I|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	632	Helical; (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TTACCCTGATCATAATCTCCT	0.433		NA											154	58					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175896743	175896743	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:175896743G>T	uc003iuc.2	+	5	737	c.67G>T	c.(67-69)GAG>TAG	p.E23*	ADAM29_uc003iud.2_Nonsense_Mutation_p.E23*|ADAM29_uc010irr.2_Nonsense_Mutation_p.E23*|ADAM29_uc011cki.1_Nonsense_Mutation_p.E23*	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	23					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CATCCAGGATGAGCACCCCCA	0.498		NA											63	20					7.56e-43	1.11e-42	1	0
FAT1	2195	broad.mit.edu	37	4	187630465	187630465	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:187630465C>G	uc003izf.2	-	2	705	c.517G>C	c.(517-519)GCC>CCC	p.A173P	FAT1_uc010iso.1_Missense_Mutation_p.A173P	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	173	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCATCCGTGGCGCTGACTCTT	0.438		NA								HNSCC(5;0.00058)			137	35					0	0	0	0
ZFP42	132625	broad.mit.edu	37	4	188924029	188924029	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:188924029G>T	uc003izg.1	+	3	313	c.68G>T	c.(67-69)AGT>ATT	p.S23I	ZFP42_uc003izh.1_Missense_Mutation_p.S23I|ZFP42_uc003izi.1_Missense_Mutation_p.S23I	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	23					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AGAGCCCCCAGTGGGGCTAAG	0.547		NA											50	15					3.22e-24	4.32e-24	1	0
SEMA5A	9037	broad.mit.edu	37	5	9052125	9052125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:9052125C>T	uc003jek.2	-	20	3417	c.2705G>A	c.(2704-2706)TGG>TAG	p.W902*		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	902	Extracellular (Potential).|TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCAGTCCGACCACTCCGACCA	0.587		NA											16	46					0	0	0	0
CTNND2	1501	broad.mit.edu	37	5	11346684	11346684	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:11346684G>T	uc003jfa.1	-	9	1573	c.1428C>A	c.(1426-1428)CAC>CAA	p.H476Q	CTNND2_uc010itt.2_Missense_Mutation_p.H385Q|CTNND2_uc011cmy.1_Missense_Mutation_p.H139Q|CTNND2_uc011cmz.1_Missense_Mutation_p.H43Q|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.H43Q	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	476					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCTGTGGGCCGTGCTGGCTGC	0.617		NA											46	98					3.68e-32	5.17e-32	1	0
DNAH5	1767	broad.mit.edu	37	5	13752361	13752361	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:13752361A>G	uc003jfd.2	-	64	10952	c.10910T>C	c.(10909-10911)CTG>CCG	p.L3637P	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3637	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCTGTCTTCCAGGTGGTTTCT	0.403		NA							Kartagener_syndrome				69	147					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13841950	13841950	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:13841950C>G	uc003jfd.2	-	33	5377	c.5335G>C	c.(5335-5337)GTC>CTC	p.V1779L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1779	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTGCCATGACAGGTTTATCC	0.383		NA							Kartagener_syndrome				49	183					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13894843	13894843	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:13894843C>A	uc003jfd.2	-	16	2389	c.2347G>T	c.(2347-2349)GAA>TAA	p.E783*		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	783	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGGAGAGCTTCATCCACTTTG	0.423		NA							Kartagener_syndrome				98	209					9.47e-33	1.34e-32	1	0
FBXL7	23194	broad.mit.edu	37	5	15936859	15936859	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:15936859A>T	uc003jfn.1	+	4	1521	c.1040A>T	c.(1039-1041)AAG>ATG	p.K347M		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	347	LRR 7.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GAGATCGCCAAGCTGGAGTCC	0.657		NA											22	12					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23526959	23526959	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:23526959G>C	uc003jgo.2	+	11	1944	c.1762G>C	c.(1762-1764)GGC>CGC	p.G588R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	588	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GTGTGGGCGGGGCTTTAGCTG	0.607		NA								HNSCC(3;0.000094)			46	157					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24505268	24505268	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:24505268C>A	uc003jgr.1	-	8	1678	c.1346G>T	c.(1345-1347)CGT>CTT	p.R449L	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	449	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGATAGTTCACGGTCAAGAGG	0.328		NA								HNSCC(23;0.051)			31	105					4.03e-09	4.64e-09	1	0
PDZD2	23037	broad.mit.edu	37	5	31983279	31983279	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:31983279C>T	uc003jhl.2	+	3	883	c.495C>T	c.(493-495)TGC>TGT	p.C165C	PDZD2_uc003jhm.2_Silent_p.C165C|PDZD2_uc011cnx.1_5'UTR	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	165	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTGAGCAGTGCTGGAATGGCG	0.527		NA											49	151					0	0	0	0
ZFR	51663	broad.mit.edu	37	5	32420208	32420208	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:32420208G>T	uc003jhr.1	-	3	218	c.138C>A	c.(136-138)AGC>AGA	p.S46R	ZFR_uc010iun.1_Missense_Mutation_p.S46R	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	46	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		CTGGCTGCTGGCTACATTGTG	0.398		NA											10	33					2.18e-05	2.36e-05	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33588885	33588885	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:33588885G>T	uc003jia.1	-	18	2847	c.2684C>A	c.(2683-2685)TCG>TAG	p.S895*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.S810*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	895	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCATGTCGCCGAGCATGCTTC	0.582		NA								HNSCC(64;0.19)	OREG0016553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	115					5.34e-22	6.99e-22	1	0
NIPBL	25836	broad.mit.edu	37	5	37064663	37064663	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:37064663C>T	uc003jkl.3	+	47	8583	c.8084C>T	c.(8083-8085)ACG>ATG	p.T2695M	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2695					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TCAGACTCTACGGAGTTGGCA	0.393		NA											107	240					0	0	0	0
C5orf34	375444	broad.mit.edu	37	5	43502545	43502545	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:43502545C>A	uc003jnz.1	-	7	1398	c.1081G>T	c.(1081-1083)GTT>TTT	p.V361F		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	361										breast(1)	1	Lung NSC(6;2.07e-05)					GATTTGAAAACAGATCCATCC	0.308		NA											74	204					1.74e-33	2.47e-33	1	0
PARP8	79668	broad.mit.edu	37	5	50128662	50128662	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:50128662A>G	uc003jon.3	+	24	2463	c.2281A>G	c.(2281-2283)AGC>GGC	p.S761G	PARP8_uc011cpz.1_Missense_Mutation_p.S653G|PARP8_uc003joo.2_Missense_Mutation_p.S761G|PARP8_uc003jop.2_Missense_Mutation_p.S719G	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	761	PARP catalytic.					intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GCCAGCTTCAAGCAGTAAAAG	0.438		NA											30	8					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89938711	89938711	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:89938711G>T	uc003kju.2	+	13	2502	c.2406G>T	c.(2404-2406)AGG>AGT	p.R802S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	802	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCGATCAAGGGGGTCCCTTG	0.403		NA											92	25					1.04e-46	1.55e-46	1	0
CHSY3	337876	broad.mit.edu	37	5	129520379	129520379	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:129520379G>T	uc003kvd.2	+	3	1544	c.1544G>T	c.(1543-1545)CGG>CTG	p.R515L		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	515	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AGCAGAGGACGGCTCATTGAC	0.468		NA											36	12					1.59e-26	2.16e-26	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140723683	140723683	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:140723683C>G	uc003ljm.1	+	1	83	c.83C>G	c.(82-84)TCC>TGC	p.S28C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Translation_Start_Site|PCDHGA3_uc011dap.1_Missense_Mutation_p.S28C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACAGGATCCGGTCAGATC	0.587		NA									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	194	70					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150924598	150924598	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:150924598C>T	uc003lue.3	-	9	6103	c.6090G>A	c.(6088-6090)CGG>CGA	p.R2030R	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2030	Extracellular (Potential).|Cadherin 17.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTGCTGCTCCCGGTCAAACG	0.512		NA											96	29					0	0	0	0
CCNJL	79616	broad.mit.edu	37	5	159680601	159680601	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:159680601G>A	uc003lyb.1	-	7	1344	c.1092C>T	c.(1090-1092)CAC>CAT	p.H364H	CCNJL_uc011dee.1_Silent_p.H316H|CCNJL_uc003lyc.1_RNA	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	364						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCCTGAACGGTGGGCCTGCA	0.662		NA											51	18					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160115002	160115002	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:160115002G>A	uc003lym.1	-	5	927	c.80C>T	c.(79-81)ACC>ATC	p.T27I	ATP10B_uc003lyp.2_Missense_Mutation_p.T27I|ATP10B_uc011deg.1_Missense_Mutation_p.T71I|ATP10B_uc003lyo.2_5'Flank	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	27	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCGGTGTGGTTTCCGATGG	0.547		NA											63	29					0	0	0	0
RNF44	22838	broad.mit.edu	37	5	175956289	175956289	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:175956289C>A	uc003mek.1	-	10	1761	c.1236G>T	c.(1234-1236)AAG>AAT	p.K412N	RNF44_uc011dfo.1_Missense_Mutation_p.K320N|RNF44_uc003mel.1_Missense_Mutation_p.K101N	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	412	RING-type; atypical.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGTGTTACCTTCAACCACT	0.582		NA											43	17					1.32e-16	1.65e-16	1	0
EXOC2	55770	broad.mit.edu	37	6	617752	617752	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:617752C>G	uc003mtd.2	-	6	754	c.620G>C	c.(619-621)GGC>GCC	p.G207A	EXOC2_uc003mte.2_Missense_Mutation_p.G207A|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	207					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		ACTGAGACCGCCTTTCACATA	0.517		NA											65	63					0	0	0	0
SYCP2L	221711	broad.mit.edu	37	6	10899058	10899058	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:10899058T>C	uc003mzo.2	+	6	739	c.443T>C	c.(442-444)ATT>ACT	p.I148T	SYCP2L_uc011din.1_5'UTR|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	148						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TTTTGTTAGATTATTTCCAGG	0.289		NA											88	31					0	0	0	0
LRRC16A	55604	broad.mit.edu	37	6	25420376	25420376	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:25420376C>T	uc011djw.1	+	3	549	c.173C>T	c.(172-174)GCG>GTG	p.A58V	LRRC16A_uc010jpx.2_Missense_Mutation_p.A58V|LRRC16A_uc010jpy.2_Missense_Mutation_p.A58V	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	58					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CTTGTAACAGCGCGAATCCCC	0.483		NA											8	234					0	0	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26107832	26107832	+	Missense_Mutation	SNP	C	C	G	rs148167379		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:26107832C>G	uc003ngj.2	-	1	533	c.490G>C	c.(490-492)GTT>CTT	p.V164L		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	164					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CCGCTCCTAACAGTTTTAGGA	0.483		NA											155	229					0	0	0	0
TRIM27	5987	broad.mit.edu	37	6	28876602	28876602	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:28876602T>A	uc003nlr.2	-	6	1261	c.902A>T	c.(901-903)GAT>GTT	p.D301V	TRIM27_uc003nls.2_Missense_Mutation_p.D301V|TRIM27_uc003nlt.1_Missense_Mutation_p.D301V	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	301	Potential.|B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TTTCTCCATATCTGACTGCAT	0.368		NA	T	RET	papillary thyroid								24	10					0	0	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283758	33283758	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:33283758C>A	uc003oeb.2	-	2	1088	c.936G>T	c.(934-936)CTG>CTT	p.L312L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.L312L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTTGGGGAACCAGGGGTGTTG	0.567		NA											48	104					7.77e-23	1.03e-22	1	0
DNAH8	1769	broad.mit.edu	37	6	38840416	38840416	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:38840416C>T	uc003ooe.1	+	48	7044	c.6444C>T	c.(6442-6444)TGC>TGT	p.C2148C		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAACAGAATGCGGAAGGCCTC	0.483		NA											66	106					0	0	0	0
KCNK17	89822	broad.mit.edu	37	6	39272355	39272355	+	Silent	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:39272355G>C	uc003ooo.2	-	3	569	c.429C>G	c.(427-429)CTC>CTG	p.L143L	KCNK17_uc003oop.2_Silent_p.L143L	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	143	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						CCACGAGGTTGAGTGGGATCC	0.637		NA											91	172					0	0	0	0
UBR2	23304	broad.mit.edu	37	6	42637959	42637959	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:42637959G>T	uc011dur.1	+	35	4011	c.4011G>T	c.(4009-4011)GCG>GCT	p.A1337A	UBR2_uc011dus.1_Silent_p.A982A|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1337					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GTAGCTGCGCGTACACCATCC	0.408		NA											69	91					2.27e-38	3.28e-38	1	0
PKHD1	5314	broad.mit.edu	37	6	51890864	51890864	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:51890864C>T	uc003pah.1	-	32	4020	c.3744G>A	c.(3742-3744)TGG>TGA	p.W1248*	PKHD1_uc003pai.2_Nonsense_Mutation_p.W1248*	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1248	Extracellular (Potential).|IPT/TIG 7.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGGTTTCACACCAGATGCTCG	0.597		NA											44	57					0	0	0	0
GSTA3	2940	broad.mit.edu	37	6	52762651	52762651	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:52762651C>T	uc003pbb.2	-	6	597	c.518G>A	c.(517-519)AGC>AAC	p.S173N	GSTA3_uc010jzq.2_Missense_Mutation_p.S117N	NM_000847	NP_000838	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	173	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)	GGAGATAAGGCTGGAGTCAAG	0.522		NA											77	128					0	0	0	0
GFRAL	389400	broad.mit.edu	37	6	55216213	55216213	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:55216213T>A	uc003pcm.1	+	5	619	c.533T>A	c.(532-534)ATA>AAA	p.I178K		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	178	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TATCAAAATATACCTTTTAAC	0.428		NA											164	222					0	0	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55441888	55441888	+	Silent	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:55441888A>C	uc003pcn.2	-	2	345	c.186T>G	c.(184-186)GCT>GCG	p.A62A	HMGCLL1_uc003pco.2_Intron|HMGCLL1_uc010jzx.2_Intron|HMGCLL1_uc011dxc.1_Intron|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron|HMGCLL1_uc003pcp.2_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	62							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			agtggatacaagccaccgtgc	0		NA											14	21					0	0	0	0
PHIP	55023	broad.mit.edu	37	6	79679576	79679576	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:79679576C>A	uc003pir.2	-	27	3407	c.3181G>T	c.(3181-3183)GCA>TCA	p.A1061S	PHIP_uc003piq.2_Missense_Mutation_p.A85S|PHIP_uc011dyp.1_Missense_Mutation_p.A1060S	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1061	Mediates interaction with IRS1 (By similarity).				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CTGTATTTTGCATCATCAAAT	0.308		NA											21	37					3.1e-05	3.35e-05	1	0
SNX14	57231	broad.mit.edu	37	6	86235871	86235871	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:86235871C>T	uc003pkr.2	-	21	2273	c.2080G>A	c.(2080-2082)GAT>AAT	p.D694N	SNX14_uc003pkp.2_Missense_Mutation_p.D557N|SNX14_uc003pkq.2_Missense_Mutation_p.D300N|SNX14_uc011dzg.1_Missense_Mutation_p.D642N|SNX14_uc003pks.2_Missense_Mutation_p.D641N|SNX14_uc003pkt.2_Missense_Mutation_p.D685N	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	694					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		AGTATCTTATCAAGAAATTGT	0.323		NA											12	24					0	0	0	0
ZNF292	23036	broad.mit.edu	37	6	87928449	87928449	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:87928449G>C	uc003plm.3	+	4	579	c.538G>C	c.(538-540)GTG>CTG	p.V180L	ZNF292_uc003pll.1_Missense_Mutation_p.G180R	NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAAGGATAAAGGTAAATTTTC	0.328		NA											6	8					0	0	0	0
GJA10	84694	broad.mit.edu	37	6	90604608	90604608	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:90604608C>T	uc011eaa.1	+	1	421	c.421C>T	c.(421-423)CAG>TAG	p.Q141*		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	141	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GTTAGAGGAGCAGAAGAGGAT	0.463		NA											49	72					0	0	0	0
LIN28B	389421	broad.mit.edu	37	6	105406115	105406115	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:105406115G>A	uc003pqv.1	+	2	355	c.152G>A	c.(151-153)CGA>CAA	p.R51Q	LIN28B_uc010kda.1_Missense_Mutation_p.R11Q	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	51	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				ATGATAAACCGAGAGGGAAGC	0.498		NA											99	154					0	0	0	0
DDO	8528	broad.mit.edu	37	6	110714170	110714170	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:110714170C>T	uc003puc.2	-	5	922	c.918G>A	c.(916-918)AGG>AGA	p.R306R	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Silent_p.R247R	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	278		Substrate (By similarity).		R -> S (in Ref. 2; BAF85718).	aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GCCTGTAGGGCCTCAAGCCCA	0.607		NA											138	221					0	0	0	0
LAMA4	3910	broad.mit.edu	37	6	112443312	112443312	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:112443312G>A	uc003pvu.2	-	32	4689	c.4380C>T	c.(4378-4380)TCC>TCT	p.S1460S	LAMA4_uc003pvv.2_Silent_p.S1453S|LAMA4_uc003pvt.2_Silent_p.S1453S	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1460					cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TAGGGCTGTTGGAAAGGTGGC	0.453		NA											80	115					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119338048	119338048	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:119338048T>C	uc003pyj.2	-	5	1742	c.1394A>G	c.(1393-1395)CAA>CGA	p.Q465R	FAM184A_uc003pyk.3_Missense_Mutation_p.Q345R|FAM184A_uc003pyl.3_Missense_Mutation_p.Q345R	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	465	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CAATCTACTTTGCAGGTTTTT	0.373		NA											54	81					0	0	0	0
THEMIS	387357	broad.mit.edu	37	6	128040968	128040968	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:128040968G>T	uc003qbi.2	-	6	2078	c.1759C>A	c.(1759-1761)CGT>AGT	p.R587S	THEMIS_uc010kfa.2_Missense_Mutation_p.R490S|THEMIS_uc011ebt.1_Missense_Mutation_p.R626S|THEMIS_uc010kfb.2_Missense_Mutation_p.R552S	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	587					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						ACGTGATGACGCTGAAATGAC	0.368		NA											74	81					2.51e-31	3.51e-31	1	0
LAMA2	3908	broad.mit.edu	37	6	129775417	129775417	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:129775417C>A	uc003qbn.2	+	46	6796	c.6691C>A	c.(6691-6693)CGT>AGT	p.R2231S	LAMA2_uc003qbo.2_Missense_Mutation_p.R2231S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2231	Laminin G-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATATTGGTACCGTATCGTAGC	0.363		NA											47	46					2.82e-22	3.7e-22	1	0
SAMD3	154075	broad.mit.edu	37	6	130465774	130465774	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:130465774G>T	uc003qbv.2	-	13	1780	c.1454C>A	c.(1453-1455)TCC>TAC	p.S485Y	SAMD3_uc003qbx.2_Missense_Mutation_p.S485Y|SAMD3_uc003qbw.2_Missense_Mutation_p.S485Y	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	485										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GAAAGTTTGGGACAGTCTTCT	0.438		NA											63	100					7.56e-43	1.11e-42	1	0
TMEM200A	114801	broad.mit.edu	37	6	130762115	130762115	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:130762115G>T	uc003qca.2	+	3	1419	c.548G>T	c.(547-549)GGC>GTC	p.G183V	TMEM200A_uc010kfh.2_Missense_Mutation_p.G183V|TMEM200A_uc010kfi.2_Missense_Mutation_p.G183V|TMEM200A_uc003qcb.2_Missense_Mutation_p.G183V	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	183	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CAAATGAACGGCATGTACACT	0.443		NA											49	62					4.11e-27	5.62e-27	1	0
TXLNB	167838	broad.mit.edu	37	6	139576740	139576740	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:139576740C>T	uc011eds.1	-	7	1203	c.1038G>A	c.(1036-1038)GCG>GCA	p.A346A		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	346	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCAGCACTTTCGCCTGAAGTT	0.512		NA											61	80					0	0	0	0
UTRN	7402	broad.mit.edu	37	6	144843114	144843114	+	Splice_Site	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:144843114A>G	uc003qkt.2	+	39	5634	c.5542_splice	c.e39-2	p.A1848_splice		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTGTTTTTGTAGGCAATCCCT	0.289		NA											3	150					0	0	0	0
MYCT1	80177	broad.mit.edu	37	6	153043144	153043144	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:153043144C>G	uc003qpd.3	+	2	472	c.464C>G	c.(463-465)TCC>TGC	p.S155C	MYCT1_uc010kjc.1_Missense_Mutation_p.S107C|MYCT1_uc003qpc.3_Missense_Mutation_p.S155C	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	155						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CAAGCAAATTCCTTTCCAAGA	0.498		NA											76	121					0	0	0	0
TMEM181	57583	broad.mit.edu	37	6	159052421	159052421	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:159052421G>T	uc003qrm.3	+	16	1771	c.1760G>T	c.(1759-1761)GGG>GTG	p.G587V		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	587					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		GTGATTTATGGGTAAGTCCCT	0.468		NA											81	127					1.33e-51	2e-51	1	0
PLG	5340	broad.mit.edu	37	6	161173182	161173182	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:161173182C>A	uc003qtm.3	+	18	2224	c.2161C>A	c.(2161-2163)CTC>ATC	p.L721I		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	721	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGAAGCCCAGCTCCCTGTGAT	0.468		NA											49	65					5.73e-26	7.77e-26	1	0
PDE10A	10846	broad.mit.edu	37	6	165832247	165832247	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:165832247C>A	uc003qun.2	-	12	1085	c.844G>T	c.(844-846)GTG>TTG	p.V282L	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.V212L|PDE10A_uc003quo.2_Missense_Mutation_p.V292L	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	282	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCGGCATTCACCAGGTTTTTT	0.353		NA											25	45					4.6e-10	5.38e-10	1	0
RAC1	5879	broad.mit.edu	37	7	6441558	6441558	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:6441558A>C	uc003spx.2	+	5	589	c.348A>C	c.(346-348)AAA>AAC	p.K116N	RAC1_uc003spw.2_Missense_Mutation_p.K135N	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	116	GTP (By similarity).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	TGGGAACTAAACTTGATCTTA	0.493		NA											79	79					0	0	0	0
C7orf26	79034	broad.mit.edu	37	7	6639935	6639936	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:6639935_6639936GG>TT	uc003sqo.1	+	4	1056_1057	c.1056_1057GG>TT	c.(1054-1059)CTGGCG>CTTTCG	p.A353S	C7orf26_uc003sqp.1_Missense_Mutation_p.A256S|C7orf26_uc003sqq.1_Missense_Mutation_p.A154S	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	353										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		TGGACCGGCTGGCGCAGGCTCT	0.668		NA											19	34					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21730396	21730396	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:21730396G>T	uc003svc.2	+	36	5990	c.5959G>T	c.(5959-5961)GGG>TGG	p.G1987W		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1987	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGTATTTCTTGGGGAAGCTAT	0.353		NA							Kartagener_syndrome				112	166					8.58e-55	1.3e-54	1	0
OSBPL3	26031	broad.mit.edu	37	7	24856232	24856232	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:24856232G>A	uc003sxf.2	-	18	2429	c.2024C>T	c.(2023-2025)CCA>CTA	p.P675L	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.P639L|OSBPL3_uc003sxh.2_Missense_Mutation_p.P644L|OSBPL3_uc003sxi.2_Missense_Mutation_p.P608L	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	675					lipid transport		lipid binding|protein binding			skin(1)	1						AACTTACACTGGCAGAGTCAC	0.448		NA											109	137					0	0	0	0
CREB5	9586	broad.mit.edu	37	7	28534558	28534558	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:28534558G>A	uc003szq.2	+	3	500	c.110G>A	c.(109-111)AGG>AAG	p.R37K	CREB5_uc003szo.2_Missense_Mutation_p.R4K|CREB5_uc003szr.2_Missense_Mutation_p.R30K	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	37	C2H2-type.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						ATGATTCATAGGCACAAACAT	0.388		NA											77	128					0	0	0	0
C7orf41	222166	broad.mit.edu	37	7	30174858	30174858	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:30174858G>T	uc011kab.1	+	1	307	c.106G>T	c.(106-108)GAC>TAC	p.D36Y	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Missense_Mutation_p.D36Y	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	36											0						TTTCTACGCCGACCCCGGCGT	0.632		NA											10	12					2.18e-05	2.36e-05	1	0
DDX56	54606	broad.mit.edu	37	7	44608736	44608736	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:44608736C>A	uc003tlg.2	-	10	1929	c.1286G>T	c.(1285-1287)CGC>CTC	p.R429L	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.R365L|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Missense_Mutation_p.R389L|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	429					rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						CACCCTGCAGCGATAGCGGAA	0.627		NA											48	62					1.48e-19	1.9e-19	1	0
POM121L12	285877	broad.mit.edu	37	7	53103882	53103882	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:53103882G>T	uc003tpz.2	+	1	534	c.518G>T	c.(517-519)TGC>TTC	p.C173F		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	173											0						CTGGACCCCTGCACCCGGGAG	0.582		NA											21	28					6.21e-17	7.78e-17	1	0
ZNF117	51351	broad.mit.edu	37	7	64439659	64439659	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:64439659T>G	uc003ttr.2	-	4	1575	c.290A>C	c.(289-291)AAT>ACT	p.N97T		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	97						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CTTGTGTCTATTTGAATTTGA	0.279		NA											35	48					0	0	0	0
CALN1	83698	broad.mit.edu	37	7	71571224	71571224	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:71571224C>T	uc003twa.3	-	3	701	c.174G>A	c.(172-174)AAG>AAA	p.K58K	CALN1_uc003twb.3_Silent_p.K100K|CALN1_uc003twc.3_Silent_p.K58K	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	58	EF-hand 1.|Cytoplasmic (Potential).|1 (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CCAGCTCCTGCTTGGAGATGA	0.567		NA											28	33					0	0	0	0
LIMK1	3984	broad.mit.edu	37	7	73521389	73521389	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:73521389C>T	uc003uaa.1	+	8	1096	c.931C>T	c.(931-933)CCG>TCG	p.P311S	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_Intron|LIMK1_uc003uab.2_Missense_Mutation_p.P277S|LIMK1_uc003uac.1_Missense_Mutation_p.P103S	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	311					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				ACTGGGCTCCCCGGCCTCCCA	0.701		NA											13	16					0	0	0	0
CACNA2D1	781	broad.mit.edu	37	7	81693670	81693670	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:81693670C>A	uc003uhr.1	-	9	985	c.729G>T	c.(727-729)TGG>TGT	p.W243C		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	243	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTTGGATGTACCTGAAACAAA	0.318		NA											28	57					2.61e-14	3.2e-14	1	0
RUNDC3B	154661	broad.mit.edu	37	7	87329865	87329865	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:87329865G>A	uc003ujb.2	+	4	829	c.418G>A	c.(418-420)GCT>ACT	p.A140T	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.A123T|RUNDC3B_uc011khe.1_Missense_Mutation_p.A123T|RUNDC3B_uc003ujc.2_Missense_Mutation_p.A123T|RUNDC3B_uc003ujd.2_Missense_Mutation_p.A45T	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	140	RUN.									skin(1)	1	Esophageal squamous(14;0.00164)					TTCTTCTAGAGCTAAGGTAAG	0.383		NA											72	142					0	0	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94879404	94879404	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:94879404G>T	uc003unp.2	+	9	2449	c.2167G>T	c.(2167-2169)GAA>TAA	p.E723*	PPP1R9A_uc010lfj.2_Nonsense_Mutation_p.E745*|PPP1R9A_uc011kif.1_Nonsense_Mutation_p.E723*|PPP1R9A_uc003unq.2_Nonsense_Mutation_p.E723*|PPP1R9A_uc011kig.1_Nonsense_Mutation_p.E723*	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	723	Interacts with TGN38 (By similarity).|Potential.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			ACAAAACATAGAAGAGAATAA	0.413		NA								HNSCC(28;0.073)			16	32					4.76e-15	5.85e-15	1	0
PON2	5445	broad.mit.edu	37	7	95034735	95034735	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:95034735C>T	uc003unv.2	-	9	1093	c.972G>A	c.(970-972)GGG>GGA	p.G324G	PON2_uc003unu.2_Silent_p.G312G|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.G237G	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	324					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			GGAGAACAGACCCATTGTTGG	0.423		NA											57	92					0	0	0	0
BRI3	25798	broad.mit.edu	37	7	97920509	97920509	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:97920509C>T	uc003upi.2	+	3	461	c.332C>T	c.(331-333)GCC>GTC	p.A111V	BRI3_uc011kip.1_Intron	NM_015379	NP_056194	O95415	BRI3_HUMAN	brain protein I3 isoform a	111	Helical; (Potential).					integral to membrane					0	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)					TGCTGTTTTGCCTTGAGGAAG	0.542		NA											98	115					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100677017	100677017	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:100677017A>T	uc003uxp.1	+	3	2373	c.2320A>T	c.(2320-2322)ACA>TCA	p.T774S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	774	Extracellular (Potential).|Ser-rich.|10.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTCTTGACACAAGCACACA	0.468		NA											226	310					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100685698	100685698	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:100685698C>A	uc003uxp.1	+	3	11054	c.11001C>A	c.(10999-11001)ATC>ATA	p.I3667I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3667	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTGTGATCACTTCTACCC	0.502		NA											86	138					4.48e-22	5.87e-22	1	0
CUX1	1523	broad.mit.edu	37	7	101837129	101837129	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:101837129A>T	uc003uyx.3	+	13	1122	c.1084A>T	c.(1084-1086)AAG>TAG	p.K362*	CUX1_uc003uys.3_Nonsense_Mutation_p.K373*|CUX1_uc003uyt.2_Nonsense_Mutation_p.K373*|CUX1_uc011kkn.1_Nonsense_Mutation_p.K334*|CUX1_uc003uyw.2_Nonsense_Mutation_p.K327*|CUX1_uc003uyv.2_Nonsense_Mutation_p.K357*|CUX1_uc003uyu.2_Nonsense_Mutation_p.K371*	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	362	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CAGCATTCTGAAGTCCATGGA	0.378		NA											24	27					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103234159	103234159	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:103234159G>T	uc003vca.2	-	27	4042	c.3882C>A	c.(3880-3882)ACC>ACA	p.T1294T	RELN_uc010liz.2_Silent_p.T1294T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1294					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGGTTTCAGGGTCAAATCTC	0.393		NA											83	153					1.55e-36	2.23e-36	1	0
GPR22	2845	broad.mit.edu	37	7	107115363	107115363	+	Silent	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:107115363T>A	uc003vef.2	+	3	2204	c.858T>A	c.(856-858)ACT>ACA	p.T286T	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	286	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						GTGTAAGAACTTCAGTTTCTG	0.408		NA											51	49					0	0	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519932	113519932	+	Silent	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:113519932T>C	uc010ljy.1	-	4	1246	c.1215A>G	c.(1213-1215)TCA>TCG	p.S405S		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	405					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TAGTTTCCTCTGAAGGTTGAT	0.413		NA											186	203					0	0	0	0
C7orf58	79974	broad.mit.edu	37	7	120629907	120629907	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:120629907G>A	uc003vjq.3	+	2	679	c.232G>A	c.(232-234)GCC>ACC	p.A78T	C7orf58_uc003vjr.1_Missense_Mutation_p.A78T|C7orf58_uc003vjs.3_Missense_Mutation_p.A78T	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	78						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CTCTGGTAATGCCCAGGAAAC	0.458		NA											60	98					0	0	0	0
FLNC	2318	broad.mit.edu	37	7	128488080	128488080	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:128488080A>G	uc003vnz.3	+	26	4747	c.4538A>G	c.(4537-4539)TAC>TGC	p.Y1513C	FLNC_uc003voa.3_Missense_Mutation_p.Y1513C	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1513	Filamin 13.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GACGGGCCCTACACGGTAGCC	0.667		NA											8	9					0	0	0	0
PLXNA4	91584	broad.mit.edu	37	7	131853075	131853075	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:131853075A>T	uc003vra.3	-	22	4503	c.4274T>A	c.(4273-4275)CTG>CAG	p.L1425Q		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1425	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CCTGAGCAGCAGCTTAGGGTG	0.612		NA											9	13					0	0	0	0
PLXNA4	91584	broad.mit.edu	37	7	131913220	131913220	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:131913220C>A	uc003vra.3	-	6	1842	c.1613G>T	c.(1612-1614)CGG>CTG	p.R538L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	538	PSI 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CCGCTCCTTCCGGGTGCAACT	0.607		NA											34	48					2.87e-16	3.57e-16	1	0
WDR91	29062	broad.mit.edu	37	7	134893687	134893687	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:134893687C>T	uc003vsp.2	-	3	429	c.367G>A	c.(367-369)GCT>ACT	p.A123T	WDR91_uc010lmq.2_5'Flank|WDR91_uc010lmr.2_5'Flank	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	123										breast(2)|ovary(1)|skin(1)	4						TTCCACTCAGCCTGGTTCTGG	0.537		NA											81	134					0	0	0	0
AKR1D1	6718	broad.mit.edu	37	7	137773407	137773407	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:137773407A>G	uc003vtz.2	+	2	223	c.154A>G	c.(154-156)ATT>GTT	p.I52V	AKR1D1_uc011kqb.1_Missense_Mutation_p.I52V|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.I52V|AKR1D1_uc011kqf.1_Missense_Mutation_p.I52V	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	52					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						GTACCGACATATTGATGGGGC	0.488		NA											32	41					0	0	0	0
WEE2	494551	broad.mit.edu	37	7	141424933	141424933	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:141424933C>A	uc003vwn.2	+	9	1735	c.1329C>A	c.(1327-1329)ATC>ATA	p.I443I	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	443	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GGCACCATATCCGCAAGGGTA	0.493		NA											49	69					8e-19	1.02e-18	1	0
MGAM	8972	broad.mit.edu	37	7	141803074	141803074	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:141803074G>A	uc003vwy.2	+	47	5385	c.5331G>A	c.(5329-5331)ACG>ACA	p.T1777T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1777	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AACAGAATACGATGCAAAGCC	0.348		NA											13	12					0	0	0	0
OR2F2	135948	broad.mit.edu	37	7	143633169	143633169	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:143633169A>T	uc011ktv.1	+	1	844	c.844A>T	c.(844-846)ATG>TTG	p.M282L		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TGCCATTGTTATGCCTCTGCT	0.463		NA											88	111					0	0	0	0
OR2A25	392138	broad.mit.edu	37	7	143772005	143772005	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:143772005G>C	uc011ktx.1	+	1	693	c.693G>C	c.(691-693)GAG>GAC	p.E231D		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					AGTCAGGAGAGGGGTGCCAGA	0.483		NA											92	140					0	0	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829578	146829578	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:146829578T>A	uc003weu.1	+	8	1841	c.1325T>A	c.(1324-1326)ATG>AAG	p.M442K		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	442	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAGACCAAGATGAGCCAAATC	0.408		NA								HNSCC(39;0.1)			48	69					0	0	0	0
AGAP3	116988	broad.mit.edu	37	7	150837179	150837179	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:150837179G>A	uc003wjg.1	+	13	1783	c.1780G>A	c.(1780-1782)GAC>AAC	p.D594N	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjj.1_Missense_Mutation_p.D93N|AGAP3_uc003wjk.1_5'UTR	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	558	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						CCCCCGACCAGACGGCCCCAG	0.607		NA											11	20					0	0	0	0
ASB10	136371	broad.mit.edu	37	7	150878289	150878289	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:150878289G>A	uc003wjm.1	-	3	1102	c.976C>T	c.(976-978)CTT>TTT	p.L326F	ASB10_uc003wjl.1_Missense_Mutation_p.L326F|ASB10_uc003wjn.1_Missense_Mutation_p.L266F	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	281	ANK 5.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCAGCTGAAAGCAGCAAGCTG	0.677		NA											27	40					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151927067	151927067	+	Missense_Mutation	SNP	T	T	C	rs60244562		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:151927067T>C	uc003wla.2	-	18	3136	c.2917A>G	c.(2917-2919)AGA>GGA	p.R973G	MLL3_uc003wkz.2_Missense_Mutation_p.R34G	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	973	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCAAGTAATCTTCCTTCTGCT	0.353		NA	N		medulloblastoma								5	458					0	0	0	0
PTPRN2	5799	broad.mit.edu	37	7	157985038	157985038	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:157985038T>C	uc003wno.2	-	5	651	c.530A>G	c.(529-531)CAG>CGG	p.Q177R	PTPRN2_uc003wnp.2_Missense_Mutation_p.Q160R|PTPRN2_uc003wnq.2_Missense_Mutation_p.Q177R|PTPRN2_uc003wnr.2_Missense_Mutation_p.Q139R|PTPRN2_uc011kwa.1_Missense_Mutation_p.Q200R	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	177	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGGTCTGTCCTGCGCCGTATG	0.677		NA											25	35					0	0	0	0
BLK	640	broad.mit.edu	37	8	11418850	11418850	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:11418850A>G	uc003wty.2	+	11	1650	c.1069A>G	c.(1069-1071)ATC>GTC	p.I357V	BLK_uc003wtz.2_Missense_Mutation_p.I286V|BLK_uc003wua.2_Missense_Mutation_p.I193V	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	357	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CATGAATTCCATCCACCGCGA	0.562		NA											25	25					0	0	0	0
PDLIM2	64236	broad.mit.edu	37	8	22442530	22442530	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:22442530G>A	uc003xby.2	+	5	716	c.316G>A	c.(316-318)GGC>AGC	p.G106S	PDLIM2_uc003xbx.1_Missense_Mutation_p.G106S|PDLIM2_uc003xbz.2_Missense_Mutation_p.G106S|PDLIM2_uc003xca.2_Missense_Mutation_p.G106S|PDLIM2_uc003xcb.2_Missense_Mutation_p.G106S|PDLIM2_uc003xcc.1_Missense_Mutation_p.G106S	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	106						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CTCTCCACAGGGCTCCGTGAG	0.637		NA											88	127					0	0	0	0
DPYSL2	1808	broad.mit.edu	37	8	26501563	26501563	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:26501563A>T	uc003xfb.1	+	10	1416	c.1066A>T	c.(1066-1068)AAT>TAT	p.N356Y	DPYSL2_uc003xfa.2_Missense_Mutation_p.N461Y|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.N320Y	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	356					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GGAGGGCACCAATGGCACTGA	0.577		NA											28	47					0	0	0	0
UNC5D	137970	broad.mit.edu	37	8	35588529	35588529	+	Splice_Site	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:35588529G>A	uc003xjr.1	+	11	2010	c.1682_splice	c.e11-1	p.G561_splice	UNC5D_uc003xjs.1_Splice_Site_p.G556_splice|UNC5D_uc003xju.1_Splice_Site_p.G137_splice	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor						apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTCTGTTTTAGGGGTGAGCTT	0.423		NA											40	41					0	0	0	0
ADAM2	2515	broad.mit.edu	37	8	39613295	39613295	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:39613295G>T	uc003xnj.2	-	16	1824	c.1749C>A	c.(1747-1749)GAC>GAA	p.D583E	ADAM2_uc003xnk.2_Missense_Mutation_p.D564E|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Missense_Mutation_p.D427E	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	583	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TCTTTTGGCTGTCTGCATGAT	0.348		NA											39	61					1.91e-15	2.35e-15	1	0
SLC20A2	6575	broad.mit.edu	37	8	42294989	42294989	+	Silent	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:42294989C>A	uc010lxl.2	-	8	1735	c.1041G>T	c.(1039-1041)GTG>GTT	p.V347V	SLC20A2_uc010lxm.2_Silent_p.V347V|SLC20A2_uc003xpe.2_Silent_p.V347V|SLC20A2_uc011lcu.1_Silent_p.V149V	NM_006749	NP_006740	Q08357	S20A2_HUMAN	solute carrier family 20, member 2	347	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AGTCTTTGTGCACGGTGTGGT	0.592		NA											87	120					8.56e-49	1.28e-48	1	0
RP1	6101	broad.mit.edu	37	8	55540694	55540694	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:55540694G>T	uc003xsd.1	+	4	4400	c.4252G>T	c.(4252-4254)GAT>TAT	p.D1418Y	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1418					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAGTTCTCTAGATGATTTTGA	0.358		NA											50	93					1.61e-24	2.16e-24	1	0
ZFHX4	79776	broad.mit.edu	37	8	77618582	77618582	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:77618582C>A	uc003yav.2	+	2	2646	c.2259C>A	c.(2257-2259)TGC>TGA	p.C753*	ZFHX4_uc003yat.1_Nonsense_Mutation_p.C753*|ZFHX4_uc003yau.1_Nonsense_Mutation_p.C753*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.C753*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	753						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCAGTGGCTGCGGAACACCCT	0.527		NA								HNSCC(33;0.089)			21	19					0.000375601	0.000398754	1	0
CNBD1	168975	broad.mit.edu	37	8	88363947	88363948	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:88363947_88363948GG>TT	uc003ydy.2	+	9	1125_1126	c.1077_1078GG>TT	c.(1075-1080)GTGGGT>GTTTGT	p.G360C		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	360	cNMP.									ovary(3)	3						TTTCTTTTGTGGGTTATATTAA	0.262		NA											5	8					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	92982970	92982970	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:92982970C>A	uc003yfd.2	-	10	1539	c.1455G>T	c.(1453-1455)AAG>AAT	p.K485N	RUNX1T1_uc003yfc.1_Missense_Mutation_p.K458N|RUNX1T1_uc003yfe.1_Missense_Mutation_p.K448N|RUNX1T1_uc010mao.2_Missense_Mutation_p.K458N|RUNX1T1_uc011lgi.1_Missense_Mutation_p.K496N|RUNX1T1_uc010man.1_Missense_Mutation_p.K110N|RUNX1T1_uc003yfb.1_Missense_Mutation_p.K448N	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	485					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGCGCTCCATCTTGGCCCTCT	0.617		NA											43	64					3.55e-21	4.6e-21	1	0
VPS13B	157680	broad.mit.edu	37	8	100866327	100866327	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:100866327G>A	uc003yiv.2	+	56	10896	c.10785G>A	c.(10783-10785)TTG>TTA	p.L3595L	VPS13B_uc003yiw.2_Silent_p.L3570L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3595					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAGTAAATTTGCTCGTCAGCA	0.542		NA											39	46					0	0	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361622	105361622	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:105361622C>G	uc003ylx.1	+	2	891	c.842C>G	c.(841-843)CCG>CGG	p.P281R		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	281					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GTCATCATCCCGACTTTCTGG	0.478		NA											110	127					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110425733	110425733	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:110425733C>T	uc003yne.2	+	21	2423	c.2319C>T	c.(2317-2319)AGC>AGT	p.S773S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	773	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTACTAGAAGCACTGATACAC	0.289		NA								HNSCC(38;0.096)			7	4					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110474049	110474049	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:110474049T>A	uc003yne.2	+	48	7399	c.7295T>A	c.(7294-7296)ATA>AAA	p.I2432K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2432	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAGAAGAAATAGGAAGTGAC	0.393		NA								HNSCC(38;0.096)			13	16					0	0	0	0
KCNV1	27012	broad.mit.edu	37	8	110984922	110984922	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:110984922G>T	uc003ynr.3	-	2	898	c.556C>A	c.(556-558)CAA>AAA	p.Q186K	KCNV1_uc010mcw.2_Missense_Mutation_p.Q186K	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	186	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CAAGGTCCTTGGGAGAAGTCC	0.458		NA											61	98					1.46e-30	2.03e-30	1	0
CSMD3	114788	broad.mit.edu	37	8	113277643	113277643	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:113277643T>C	uc003ynu.2	-	60	9844	c.9685A>G	c.(9685-9687)AGA>GGA	p.R3229G	CSMD3_uc003yns.2_Missense_Mutation_p.R2431G|CSMD3_uc003ynt.2_Missense_Mutation_p.R3189G|CSMD3_uc011lhx.1_Missense_Mutation_p.R3060G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3229	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATCATACCTCTACAAGTTGGC	0.294		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			81	114					0	0	0	0
ENPP2	5168	broad.mit.edu	37	8	120602744	120602744	+	Splice_Site	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:120602744C>A	uc003yot.1	-	13	1293	c.1207_splice	c.e13+1	p.Y403_splice	ENPP2_uc003yor.1_Splice_Site_p.Y42_splice|ENPP2_uc003yos.1_Splice_Site_p.Y455_splice|ENPP2_uc010mdd.1_Splice_Site_p.Y403_splice	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein						cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATCAACTTACATTTAGCATT	0.239		NA											29	39					7.38e-10	8.6e-10	1	0
COL14A1	7373	broad.mit.edu	37	8	121240971	121240971	+	Silent	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:121240971A>T	uc003yox.2	+	18	2425	c.2160A>T	c.(2158-2160)CCA>CCT	p.P720P	COL14A1_uc003yoy.2_Silent_p.P398P	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	720					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGACAGAACCAGCTACAACCA	0.284		NA											62	91					0	0	0	0
EFR3A	23167	broad.mit.edu	37	8	132971846	132971846	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:132971846A>G	uc003yte.2	+	8	992	c.791A>G	c.(790-792)CAC>CGC	p.H264R		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	264						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTAGATCATCACAAACTGTGG	0.279		NA											40	69					0	0	0	0
ZFAT	57623	broad.mit.edu	37	8	135612791	135612791	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:135612791T>C	uc003yup.2	-	7	2538	c.2363A>G	c.(2362-2364)CAC>CGC	p.H788R	ZFAT_uc003yun.2_Missense_Mutation_p.H776R|ZFAT_uc003yuo.2_Missense_Mutation_p.H776R|ZFAT_uc010meh.2_Missense_Mutation_p.H776R|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.H776R|ZFAT_uc010mej.2_Missense_Mutation_p.H726R|ZFAT_uc003yur.2_Missense_Mutation_p.H776R|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	788	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTGAATTACGTGGCGTTTAAG	0.428		NA											90	151					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139180143	139180143	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:139180143G>T	uc003yuy.2	-	12	1424	c.1253C>A	c.(1252-1254)GCG>GAG	p.A418E	FAM135B_uc003yux.2_Missense_Mutation_p.A319E|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	418										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAAACCTGTCGCAGGGCAGTC	0.507		NA								HNSCC(54;0.14)			91	114					1.37e-43	2.02e-43	1	0
COL22A1	169044	broad.mit.edu	37	8	139638470	139638470	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:139638470G>T	uc003yvd.2	-	51	4127	c.3680C>A	c.(3679-3681)CCT>CAT	p.P1227H	COL22A1_uc011ljo.1_Missense_Mutation_p.P507H	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1227	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGGGGCCAGGAGGGCCTTC	0.403		NA								HNSCC(7;0.00092)			33	78					1.04e-10	1.24e-10	1	0
COL22A1	169044	broad.mit.edu	37	8	139642958	139642958	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:139642958G>A	uc003yvd.2	-	50	4090	c.3643C>T	c.(3643-3645)CCA>TCA	p.P1215S	COL22A1_uc011ljo.1_Missense_Mutation_p.P495S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1215	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGGATTCCTGGTGGTCCAGCA	0.478		NA								HNSCC(7;0.00092)			150	202					0	0	0	0
SCRIB	23513	broad.mit.edu	37	8	144877207	144877207	+	Splice_Site	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:144877207C>A	uc003yzp.1	-	27	3853	c.3846_splice	c.e27+1	p.R1282_splice	SCRIB_uc003yzn.1_Splice_Site|SCRIB_uc003yzo.1_Splice_Site_p.R1282_splice	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b						activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGGGCACTCACCCTCTGCACG	0.682		NA											21	37					1.64e-05	1.78e-05	1	0
RECQL4	9401	broad.mit.edu	37	8	145739431	145739431	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:145739431G>T	uc003zdj.2	-	12	1971	c.1939C>A	c.(1939-1941)CGC>AGC	p.R647S		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	647	Helicase ATP-binding.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CTGGCAGTGCGGCGTGTGGCT	0.672		NA	N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				4	4					1.24e-05	1.35e-05	1	0
MPDZ	8777	broad.mit.edu	37	9	13196141	13196141	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:13196141C>T	uc010mia.1	-	12	1692	c.1635G>A	c.(1633-1635)ATG>ATA	p.M545I	MPDZ_uc010mhy.2_Missense_Mutation_p.M545I|MPDZ_uc010mhz.2_Missense_Mutation_p.M545I|MPDZ_uc011lmn.1_Missense_Mutation_p.M545I|MPDZ_uc003zlb.3_Missense_Mutation_p.M545I	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	545					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		AGTTAATTCCCATAATCCTTT	0.383		NA											11	3					0	0	0	0
TLN1	7094	broad.mit.edu	37	9	35717418	35717418	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:35717418C>A	uc003zxt.2	-	19	2537	c.2183G>T	c.(2182-2184)AGC>ATC	p.S728I		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	728					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GACAGGTGAGCTGATTGTAGG	0.557		NA											68	25					9.54e-23	1.26e-22	1	0
ZNF658	26149	broad.mit.edu	37	9	40774556	40774556	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:40774556T>C	uc004abs.2	-	5	871	c.719A>G	c.(718-720)GAA>GGA	p.E240G	ZNF658_uc010mmm.1_Missense_Mutation_p.E240G|ZNF658_uc010mmn.1_Missense_Mutation_p.E240G	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACAGGACTTTTCTCCTGTTAG	0.323		NA											74	87					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43630658	43630658	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:43630658G>A	uc011lrb.1	-	1	73	c.44C>T	c.(43-45)TCG>TTG	p.S15L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	15						integral to membrane					0						GGCGTTTAGCGATGAGGCACT	0.488		NA											80	25					0	0	0	0
RORB	6096	broad.mit.edu	37	9	77257706	77257706	+	Silent	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:77257706A>G	uc004aji.2	+	4	694	c.645A>G	c.(643-645)GCA>GCG	p.A215A	RORB_uc004ajh.2_Silent_p.A204A	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	215	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GGCAGTTAGCACCAGGGATAA	0.408		NA											47	70					0	0	0	0
C9orf79	286234	broad.mit.edu	37	9	90502556	90502556	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:90502556A>C	uc004app.3	+	4	3189	c.3154A>C	c.(3154-3156)AGT>CGT	p.S1052R		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1052						integral to membrane				ovary(3)	3						CTTGGGAGCCAGTGTGAGGGC	0.592		NA											64	121					0	0	0	0
C9orf79	286234	broad.mit.edu	37	9	90503213	90503213	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:90503213C>A	uc004app.3	+	4	3846	c.3811C>A	c.(3811-3813)CCA>ACA	p.P1271T		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1271						integral to membrane				ovary(3)	3						CAGTCACCATCCACAGGGTCT	0.542		NA											31	73					1.08e-15	1.34e-15	1	0
IARS	3376	broad.mit.edu	37	9	95050422	95050422	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:95050422G>T	uc004art.1	-	3	519	c.262C>A	c.(262-264)CAT>AAT	p.H88N	IARS_uc004ars.1_5'UTR|IARS_uc004aru.3_Missense_Mutation_p.H88N|IARS_uc010mqr.2_Intron|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	88					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	GGTAAGCCATGGCAATCCCAT	0.333		NA											62	71					9.5e-31	1.33e-30	1	0
NOL8	55035	broad.mit.edu	37	9	95077690	95077690	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:95077690G>C	uc004arv.2	-	7	1554	c.1217C>G	c.(1216-1218)TCT>TGT	p.S406C	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.S338C	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	406					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TTTCTTCGTAGATTTTTCCAT	0.328		NA											17	17					0	0	0	0
ZNF782	158431	broad.mit.edu	37	9	99580614	99580614	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:99580614C>G	uc004awp.1	-	6	1972	c.1691G>C	c.(1690-1692)TGT>TCT	p.C564S	ZNF782_uc011lup.1_Missense_Mutation_p.C432S	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	564	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				ACAATGATTACATTTATAGGG	0.413		NA											156	254					0	0	0	0
RAD23B	5887	broad.mit.edu	37	9	110086243	110086243	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:110086243C>T	uc004bde.2	+	8	1257	c.890C>T	c.(889-891)TCC>TTC	p.S297F	RAD23B_uc011lwa.1_Missense_Mutation_p.S297F|RAD23B_uc011lwb.1_Missense_Mutation_p.S276F	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	297	STI1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						CAGAATCCTTCCTTGCTTCCA	0.388		NA						Direct_reversal_of_damage|NER					79	111					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898848	112898848	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:112898848G>T	uc004bei.2	+	9	1912	c.1720G>T	c.(1720-1722)GCA>TCA	p.A574S	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.A342S|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.A342S|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.A152S|AKAP2_uc011lwi.1_Missense_Mutation_p.A200S|AKAP2_uc004bem.2_Missense_Mutation_p.A200S|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.A160S|AKAP2_uc011lwj.1_Missense_Mutation_p.A111S|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.A111S	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	111							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TAGCCGGCAGGCACCTCCTCA	0.622		NA											58	66					1.31e-36	1.89e-36	1	0
COL27A1	85301	broad.mit.edu	37	9	117050772	117050772	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:117050772C>A	uc011lxl.1	+	42	4025	c.4025C>A	c.(4024-4026)CCT>CAT	p.P1342H	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1342	Collagen-like 12.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GAGGGGCCCCCTGGGCCACCT	0.662		NA											7	13					0.00448238	0.00463867	1	0
TNC	3371	broad.mit.edu	37	9	117793913	117793913	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:117793913G>T	uc004bjj.3	-	23	6201	c.5839C>A	c.(5839-5841)CCA>ACA	p.P1947T	TNC_uc010mvf.2_Missense_Mutation_p.P1674T	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1947	Fibronectin type-III 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TGGGTGGATGGGCTCAGGTCT	0.512		NA											78	117					2.72e-29	3.77e-29	1	0
TLR4	7099	broad.mit.edu	37	9	120476539	120476539	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:120476539C>A	uc004bjz.2	+	3	2424	c.2133C>A	c.(2131-2133)GAC>GAA	p.D711E	TLR4_uc004bka.2_Missense_Mutation_p.D671E|TLR4_uc004bkb.2_Missense_Mutation_p.D511E	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	711	Cytoplasmic (Potential).|TIR.			D->K: Abolishes LPS-response.	activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ACTACAGAGACTTTATTCCCG	0.473		NA											68	85					2.19e-23	2.91e-23	1	0
DBC1	1620	broad.mit.edu	37	9	121930238	121930238	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:121930238C>T	uc004bkc.2	-	8	1866	c.1410G>A	c.(1408-1410)CGG>CGA	p.R470R		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	470					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						ACTGCTCGCTCCGCTCCGAGT	0.582		NA											29	62					0	0	0	0
TMEM8C	389827	broad.mit.edu	37	9	136380685	136380685	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:136380685G>A	uc011mdk.1	-	4	444	c.444C>T	c.(442-444)AGC>AGT	p.S148S		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	148						integral to membrane					0						GGGTGTAGACGCTCTTGTCTG	0.597		NA											47	68					0	0	0	0
CSF2RA	1438	broad.mit.edu	37	X	1407468	1407468	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:1407468C>T	uc010nct.2	+	6	598	c.276C>T	c.(274-276)GTC>GTT	p.V92V	CSF2RA_uc011mhb.1_Silent_p.V92V|CSF2RA_uc004cpq.2_Silent_p.V92V|CSF2RA_uc004cpn.2_Silent_p.V92V|CSF2RA_uc004cpo.2_Silent_p.V92V|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_5'UTR|CSF2RA_uc004cpp.2_Silent_p.V92V|CSF2RA_uc010ncv.2_Silent_p.V92V|CSF2RA_uc004cpr.2_Silent_p.V92V	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	92	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ATGAAGGAGTCACATTTGAGG	0.423		NA											163	292					0	0	0	0
IL3RA	3563	broad.mit.edu	37	X	1464240	1464240	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:1464240G>C	uc004cps.2	+	3	445	c.96G>C	c.(94-96)ATG>ATC	p.M32I	IL3RA_uc011mhd.1_Intron	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	32	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACCTAAGGATGAAAGCAAAGG	0.443		NA											5	353					0	0	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069249	6069249	+	Silent	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:6069249G>T	uc010ndh.2	-	2	760	c.259C>A	c.(259-261)CGG>AGG	p.R87R	NLGN4X_uc004crp.2_Silent_p.R87R|NLGN4X_uc004crq.2_Silent_p.R87R|NLGN4X_uc010ndi.2_Silent_p.R87R|NLGN4X_uc004crr.2_Silent_p.R87R|NLGN4X_uc010ndj.2_Silent_p.R87R	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	87	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGCTGAAACCGCCTCTCTCCA	0.572		NA											75	12					6.21e-33	8.77e-33	1	0
MAGEB4	4115	broad.mit.edu	37	X	30260672	30260672	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:30260672C>T	uc004dcb.2	+	1	504	c.420C>T	c.(418-420)AGC>AGT	p.S140S	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	140	MAGE.									ovary(1)	1						AGATCATCAGCAAAAAGTACA	0.473		NA											25	3					0	0	0	0
DMD	1756	broad.mit.edu	37	X	31893375	31893375	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:31893375C>G	uc004dda.1	-	48	7272	c.7028G>C	c.(7027-7029)TGG>TCG	p.W2343S	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.W999S|DMD_uc004dcx.2_Missense_Mutation_p.W1002S|DMD_uc004dcz.2_Missense_Mutation_p.W2220S|DMD_uc004dcy.1_Missense_Mutation_p.W2339S|DMD_uc004ddb.1_Missense_Mutation_p.W2335S|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2343			Missing (in DMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGGAGATAACCACAGCAGCAG	0.368		NA											22	7					0	0	0	0
FAM47C	442444	broad.mit.edu	37	X	37027498	37027498	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:37027498G>T	uc004ddl.1	+	1	1029	c.1015G>T	c.(1015-1017)GTG>TTG	p.V339L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	339										ovary(3)	3						CAAGACTCTGGTGTCCAGTCT	0.622		NA											88	22					1.07e-62	1.63e-62	1	0
WDR45	11152	broad.mit.edu	37	X	48933527	48933527	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:48933527C>G	uc004dmk.1	-	7	686	c.514G>C	c.(514-516)GTG>CTG	p.V172L	PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Missense_Mutation_p.V70L|WDR45_uc004dmj.1_Missense_Mutation_p.V133L|WDR45_uc004dml.1_Missense_Mutation_p.V173L|WDR45_uc004dmm.1_Missense_Mutation_p.V137L|WDR45_uc010nim.1_Missense_Mutation_p.V172L|WDR45_uc004dmn.1_Missense_Mutation_p.V63L|WDR45_uc004dmo.1_Missense_Mutation_p.V195L|WDR45_uc004dmp.1_Missense_Mutation_p.V173L	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	172					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						CGGCTCACCACAAGTTGCAGA	0.597		NA											31	3					0	0	0	0
PAGE4	9506	broad.mit.edu	37	X	49597193	49597193	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:49597193G>T	uc004don.1	+	4	311	c.232G>T	c.(232-234)GGC>TGC	p.G78C		NM_007003	NP_008934	O60829	GAGC1_HUMAN	G antigen, family C, 1	78											0	Ovarian(276;0.236)					GCGTGGAGATGGCTCTGATGT	0.388		NA											57	12					4.14e-29	5.71e-29	1	0
WNK3	65267	broad.mit.edu	37	X	54359590	54359590	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:54359590C>A	uc004dtd.1	-	2	956	c.517G>T	c.(517-519)GTT>TTT	p.V173F	WNK3_uc004dtc.1_Missense_Mutation_p.V173F	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	173	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CACCAAGCAACCTCAACCCAT	0.393		NA											83	22					3.17e-35	4.53e-35	1	0
MSN	4478	broad.mit.edu	37	X	64959590	64959590	+	Splice_Site	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:64959590G>T	uc004dwf.2	+	13	1768	c.1570_splice	c.e13-1	p.A524_splice		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin						leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CATCCTCACAGGCCCTCACTT	0.483		NA	T	ALK	ALCL								54	15					2.65e-33	3.74e-33	1	0
EDA2R	60401	broad.mit.edu	37	X	65824895	65824895	+	Silent	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:65824895C>T	uc004dwq.2	-	2	272	c.261G>A	c.(259-261)TTG>TTA	p.L87L	EDA2R_uc004dwr.2_Silent_p.L87L|EDA2R_uc004dws.2_Silent_p.L87L|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Intron|EDA2R_uc010nkt.1_Silent_p.L87L|EDA2R_uc004dwt.1_Silent_p.L87L	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	87	TNFR-Cys 3.|Extracellular (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						CTCACCTGGGCAAACAGTCCC	0.488		NA											10	2					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961161	73961161	+	Silent	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:73961161A>G	uc004eby.2	-	3	3848	c.3231T>C	c.(3229-3231)CCT>CCC	p.P1077P		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1077					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGGAAAGACTAGGGGTGTCCG	0.502		NA											102	34					0	0	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83371245	83371245	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:83371245C>T	uc004eej.1	-	12	1077	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	RPS6KA6_uc011mqt.1_Missense_Mutation_p.D334N|RPS6KA6_uc011mqu.1_Missense_Mutation_p.D231N	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	334	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						ACATCCCAGTCAATATTTGCA	0.234		NA											28	2					0	0	0	0
HDX	139324	broad.mit.edu	37	X	83616510	83616510	+	Silent	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:83616510C>G	uc004eek.1	-	5	1525	c.1416G>C	c.(1414-1416)GTG>GTC	p.V472V	HDX_uc011mqv.1_Silent_p.V472V|HDX_uc004eel.1_Silent_p.V414V	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	472	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						ATTCAGTTGCCACAGCTTCAA	0.393		NA											27	8					0	0	0	0
POF1B	79983	broad.mit.edu	37	X	84634342	84634342	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:84634342G>T	uc004eer.2	-	2	264	c.118C>A	c.(118-120)CAG>AAG	p.Q40K	POF1B_uc004ees.2_Missense_Mutation_p.Q40K	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	40							actin binding				0						GGAGGCTGCTGGGCTTGGCTT	0.577		NA											34	4					3.21e-22	4.22e-22	1	0
DACH2	117154	broad.mit.edu	37	X	85994839	85994839	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:85994839T>A	uc004eew.2	+	7	1364	c.1194T>A	c.(1192-1194)AGT>AGA	p.S398R	DACH2_uc004eex.2_Missense_Mutation_p.S385R|DACH2_uc010nmq.2_Missense_Mutation_p.S264R|DACH2_uc011mra.1_Missense_Mutation_p.S231R|DACH2_uc010nmr.2_Missense_Mutation_p.S179R|DACH2_uc004eey.2_Missense_Mutation_p.S81R|DACH2_uc004eez.2_Missense_Mutation_p.S81R	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CCAGCAGCAGTGTGTCCAGCT	0.458		NA											21	3					0	0	0	0
NOX1	27035	broad.mit.edu	37	X	100117442	100117442	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:100117442A>G	uc004egj.2	-	6	816	c.610T>C	c.(610-612)TTC>CTC	p.F204L	uc010nnf.2_Intron|NOX1_uc004egl.3_Missense_Mutation_p.F204L|NOX1_uc010nne.2_Missense_Mutation_p.F167L	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	204	Cytoplasmic (Potential).|Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						GTATACCAGAAGACTTCAAAA	0.463		NA											218	48					0	0	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104478565	104478565	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:104478565G>A	uc004elz.1	+	4	1176	c.420G>A	c.(418-420)CTG>CTA	p.L140L		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	140	Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AATCAGGCCTGTGCTACAACA	0.403		NA											152	39					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122598930	122598930	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:122598930A>T	uc004etq.3	+	14	2584	c.2291A>T	c.(2290-2292)TAT>TTT	p.Y764F	GRIA3_uc004etr.3_Missense_Mutation_p.Y764F|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	764	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TCCAAAGGCTATGGTGTGGCA	0.428		NA											91	20					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135439903	135439903	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:135439903A>T	uc004ezu.1	+	10	7259	c.6968A>T	c.(6967-6969)TAT>TTT	p.Y2323F	GPR112_uc010nsb.1_Missense_Mutation_p.Y2118F|GPR112_uc010nsc.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2323	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAATTTCCTATGTACCATAC	0.368		NA											147	35					0	0	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717687	142717687	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:142717687A>G	uc004fbx.2	-	2	1614	c.1238T>C	c.(1237-1239)ATT>ACT	p.I413T	SLITRK4_uc004fby.2_Missense_Mutation_p.I413T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	413	Extracellular (Potential).|LRR 8.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AATCACTGTAATTTGATTGCT	0.388		NA											131	25					0	0	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905948	144905948	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:144905948T>A	uc004fcd.2	+	5	2995	c.2005T>A	c.(2005-2007)TAT>AAT	p.Y669N	SLITRK2_uc010nsp.2_Missense_Mutation_p.Y669N|SLITRK2_uc010nso.2_Missense_Mutation_p.Y669N|SLITRK2_uc011mwq.1_Missense_Mutation_p.Y669N|SLITRK2_uc011mwr.1_Missense_Mutation_p.Y669N|SLITRK2_uc011mws.1_Missense_Mutation_p.Y669N|SLITRK2_uc004fcg.2_Missense_Mutation_p.Y669N|SLITRK2_uc011mwt.1_Missense_Mutation_p.Y669N|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	669	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCAATTACAGTATGGGTCTTA	0.478		NA											85	15					0	0	0	0
GABRA3	2556	broad.mit.edu	37	X	151514091	151514091	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:151514091A>G	uc010ntk.1	-	3	464	c.224T>C	c.(223-225)CTG>CCG	p.L75P		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	75	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATAGCCGTCCAGAAGACGATC	0.473		NA											67	14					0	0	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869846	151869846	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:151869846C>G	uc004ffq.1	+	3	730	c.536C>G	c.(535-537)GCC>GGC	p.A179G	MAGEA6_uc004ffr.1_Missense_Mutation_p.A179G|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	179	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TACATCTTTGCCACCTGCCTG	0.527		NA											102	18					0	0	0	0
RPS4Y2	140032	broad.mit.edu	37	Y	22930714	22930714	+	Silent	SNP	G	G	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrY:22930714G>A	uc011nbb.1	+	5	480	c.384G>A	c.(382-384)AAG>AAA	p.K128K		NM_001039567	NP_001034656	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	128					translation	ribosome	rRNA binding|structural constituent of ribosome				0						AAGTGAGGAAGATTACTGTGG	0.438		NA											49	8					0	0	0	0
GNL2	29889	broad.mit.edu	37	1	38039946	38039946	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:38039946delG	uc001cbk.2	-	12	1577	c.1414delC	c.(1414-1416)CAGfs	p.Q472fs		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	472					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				GCTCTTACCTGGGGGGCCACA	0.542		NA											16	23	---	---	---	---	NA	NA	NA	NA
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:72094757delT	uc001sws.2	+	6	1576	c.993delT	c.(991-993)GGTfs	p.G331fs	TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331	Helical; (Potential).					integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433		NA											8	474	---	---	---	---	NA	NA	NA	NA
RNF17	56163	broad.mit.edu	37	13	25362210	25362211	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:25362210_25362211insA	uc001upr.2	+	7	737_738	c.696_697insA	c.(694-699)GAGAAAfs	p.E232fs	RNF17_uc010tdd.1_Frame_Shift_Ins_p.E91fs|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Frame_Shift_Ins_p.E232fs|RNF17_uc001ups.2_Frame_Shift_Ins_p.E171fs|RNF17_uc001upq.1_Frame_Shift_Ins_p.E232fs	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	232_233					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ACATTGAAGAGAAAAAAAATAA	0.307		NA											42	31	---	---	---	---	NA	NA	NA	NA
CYLD	1540	broad.mit.edu	37	16	50785545	50785545	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:50785545delG	uc002egp.1	+	5	950	c.535delG	c.(535-537)GGGfs	p.G179fs	CYLD_uc002egn.1_Frame_Shift_Del_p.G179fs|CYLD_uc002ego.2_Frame_Shift_Del_p.G179fs|CYLD_uc010cbs.1_Frame_Shift_Del_p.G179fs|CYLD_uc002egq.1_Frame_Shift_Del_p.G179fs|CYLD_uc002egr.1_Frame_Shift_Del_p.G179fs|CYLD_uc002egs.1_Frame_Shift_Del_p.G179fs	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	179	CAP-Gly 1.|Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TTTCACTGACGGGGTGTACCA	0.418		NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				121	61	---	---	---	---	NA	NA	NA	NA
RAI1	10743	broad.mit.edu	37	17	17698946	17698946	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:17698946delC	uc002grm.2	+	3	3153	c.2684delC	c.(2683-2685)GCCfs	p.A895fs	RAI1_uc002grn.1_Frame_Shift_Del_p.A895fs	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	895						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		TCACCCAAGGCCCCACTCATC	0.652		NA											31	47	---	---	---	---	NA	NA	NA	NA
C17orf104	284071	broad.mit.edu	37	17	42744329	42744330	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:42744329_42744330insA	uc010czv.2	+	5	1050_1051	c.1050_1051insA	c.(1048-1053)AGCAAAfs	p.S350fs	C17orf104_uc002igy.1_Frame_Shift_Ins_p.S184fs|C17orf104_uc002igz.3_Frame_Shift_Ins_p.S184fs|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Frame_Shift_Ins_p.S184fs	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	350_351										central_nervous_system(1)	1						TCCAAGATAGCAAAAAATTAGC	0.347		NA											11	22	---	---	---	---	NA	NA	NA	NA
CDC27	996	broad.mit.edu	37	17	45219355	45219355	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:45219355delC	uc002ild.3	-	12	1542	c.1415delG	c.(1414-1416)GGTfs	p.G472fs	CDC27_uc002ile.3_Frame_Shift_Del_p.G478fs|CDC27_uc002ilf.3_Frame_Shift_Del_p.G471fs|CDC27_uc010wkp.1_Frame_Shift_Del_p.G411fs|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	472					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						AGCTAAATAACCTTTCCCCAT	0.368		NA											7	384	---	---	---	---	NA	NA	NA	NA
PIGN	23556	broad.mit.edu	37	18	59821827	59821827	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:59821827delC	uc002lii.3	-	7	948	c.500delG	c.(499-501)GGTfs	p.G167fs	PIGN_uc002lij.3_Frame_Shift_Del_p.G167fs	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	167	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ATCTTGAGCACCAAAATCCTC	0.313		NA											77	200	---	---	---	---	NA	NA	NA	NA
HOXD4	3233	broad.mit.edu	37	2	177016671	177016671	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:177016671delC	uc002uks.2	+	1	559	c.310delC	c.(310-312)CCGfs	p.P104fs		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	104						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		ggcgcctccgccggcgcccct	0.562		NA											16	22	---	---	---	---	NA	NA	NA	NA
ZSWIM2	151112	broad.mit.edu	37	2	187703843	187703844	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:187703843_187703844insC	uc002upu.1	-	4	376_377	c.336_337insG	c.(334-339)GGGATAfs	p.G112fs		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	112_113					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ACTCGATGTATCCCCCGAAGCA	0.391		NA											111	214	---	---	---	---	NA	NA	NA	NA
ANO10	55129	broad.mit.edu	37	3	43474181	43474181	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:43474181delG	uc003cmv.2	-	12	2007	c.1836delC	c.(1834-1836)GCCfs	p.A612fs	ANO10_uc011azs.1_Intron|ANO10_uc003cmw.2_Frame_Shift_Del_p.A546fs|ANO10_uc010hil.2_Frame_Shift_Del_p.A422fs|ANO10_uc011azt.1_Frame_Shift_Del_p.A501fs	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	612	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						TATCAGGTATGGCAAATGCAA	0.423		NA											59	18	---	---	---	---	NA	NA	NA	NA
ITPR3	3710	broad.mit.edu	37	6	33657174	33657175	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:33657174_33657175insG	uc011drk.1	+	50	7073_7074	c.6854_6855insG	c.(6853-6855)CTGfs	p.L2285fs	ITPR3_uc003oey.2_Frame_Shift_Ins_p.L372fs	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2285	Helical; (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CTCAACATCCTGGGTGCCCTCA	0.614		NA											38	73	---	---	---	---	NA	NA	NA	NA
JPH1	56704	broad.mit.edu	37	8	75233335	75233340	+	In_Frame_Del	DEL	TAGCCC	TAGCCC	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:75233335_75233340delTAGCCC	uc003yae.2	-	1	223_228	c.183_188delGGGCTA	c.(181-189)CAGGGCTAC>CAC	p.61_63QGY>H	JPH1_uc003yaf.2_In_Frame_Del_p.61_63QGY>H|JPH1_uc003yag.1_Intron	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	61_63	Gly-rich.|MORN 3.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTGCGCCCAGTAGCCCTGGTAGGTGT	0.684		NA											11	41	---	---	---	---	NA	NA	NA	NA
CDKN2A	1029	broad.mit.edu	37	9	21968233	21968233	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:21968233delC	uc003zpk.2	-	3	678	c.466delG	c.(466-468)GATfs	p.D156fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	156					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(4)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TTCTTTCAATCGGGGATGTCT	0.562		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			31	14	---	---	---	---	NA	NA	NA	NA
RPS6KA3	6197	broad.mit.edu	37	X	20195158	20195159	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:20195158_20195159delCT	uc004czu.2	-	11	889_890	c.889_890delAG	c.(889-891)AGTfs	p.S297fs	RPS6KA3_uc011mjk.1_Frame_Shift_Del_p.S268fs|RPS6KA3_uc004czv.2_Frame_Shift_Del_p.S285fs|RPS6KA3_uc011mjl.1_Frame_Shift_Del_p.S269fs|RPS6KA3_uc011mjm.1_Frame_Shift_Del_p.S269fs	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	297	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						TCGTAAAAGACTCTGCGCTTCA	0.307		NA											94	22	---	---	---	---	NA	NA	NA	NA
SLITRK4	139065	broad.mit.edu	37	X	142717956	142717957	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:142717956_142717957insT	uc004fbx.2	-	2	1344_1345	c.968_969insA	c.(967-969)AACfs	p.N323fs	SLITRK4_uc004fby.2_Frame_Shift_Ins_p.N323fs	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	323	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGATTGCGGTTGGAGAGGGC	0.465		NA											128	29	---	---	---	---	NA	NA	NA	NA