Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MACROD2	140733	broad.mit.edu	37	20	14665497	14665497	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:14665497T>G	ENST00000217246.4	+	5	705	c.310T>G	c.(310-312)Tgt>Ggt	p.C104G	MACROD2_ENST00000310348.4_Missense_Mutation_p.C104G|MACROD2_ENST00000464883.1_3'UTR	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	104	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				AGTGGATGGCTGTATTCATAG	0.418000													14	149					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200586969	200586969	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:200586969G>A	ENST00000367350.4	-	2	1321	c.883C>T	c.(883-885)Cag>Tag	p.Q295*		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	295	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						CTCTTAAGCTGAGGCAGGCTG	0.363000													22	120					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016807	33016807	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:33016807G>C	ENST00000357505.6	-	7	1926	c.1822C>G	c.(1822-1824)Cag>Gag	p.Q608E	N4BP2L2_ENST00000446957.2_Intron|N4BP2L2_ENST00000504114.1_Missense_Mutation_p.Q608E|N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000399396.3_Missense_Mutation_p.Q623E	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	0										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ACTCTTGTCTGAGATTCGAAA	0.318000													4	28					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711877	140711877	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:140711877C>T	ENST00000517417.1	+	1	1626	c.1626C>T	c.(1624-1626)ctC>ctT	p.L542L	PCDHGA1_ENST00000378105.3_Silent_p.L542L	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCGCCCCTCAGCAGCAACG	0.617000													32	180					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115137119	115137119	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:115137119C>T	ENST00000393274.1	-	18	3031	c.2406G>A	c.(2404-2406)ttG>ttA	p.L802L	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393277.1_Silent_p.L690L|DENND2C_ENST00000393276.3_Silent_p.L745L	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	802										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTCCTGAGTCAAGATTTCAT	0.378000													13	79					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768818	31768818	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:31768818C>T	ENST00000240587.4	-	2	2208	c.1881G>A	c.(1879-1881)aaG>aaA	p.K627K		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	627					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GCTCCTTCATCTTCTCCTCCA	0.582000													9	77					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904567	5904567	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:5904567C>A	ENST00000378961.4	+	4	1981	c.1777C>A	c.(1777-1779)Ccc>Acc	p.P593T		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	593						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CGCCAGGGTCCCCAAGCTGGA	0.493000													11	51					9.70103e-10	1.06105e-09	1	1	0
COLGALT2	23127	broad.mit.edu	37	1	183908151	183908151	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:183908151T>C	ENST00000361927.4	-	12	1996	c.1625A>G	c.(1624-1626)tAt>tGt	p.Y542C	COLGALT2_ENST00000367521.1_Missense_Mutation_p.Y150C|COLGALT2_ENST00000486375.1_Intron|COLGALT2_ENST00000367520.3_Missense_Mutation_p.Y279C|COLGALT2_ENST00000546159.1_Intron	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		CCTGGATTCATAATACTCCTT	0.552000													5	31					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55256367	55256367	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:55256367G>A	ENST00000381298.2	-	8	1148	c.836C>T	c.(835-837)tCc>tTc	p.S279F	IL6ST_ENST00000381293.2_Missense_Mutation_p.S113F|IL6ST_ENST00000381294.3_Missense_Mutation_p.S279F|IL6ST_ENST00000381287.4_Missense_Mutation_p.S279F|IL6ST_ENST00000502326.3_Missense_Mutation_p.S279F|IL6ST_ENST00000536319.1_Missense_Mutation_p.S279F|IL6ST_ENST00000336909.5_Missense_Mutation_p.S279F|IL6ST_ENST00000522633.2_Missense_Mutation_p.S279F|IL6ST_ENST00000381286.3_Intron	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	279	Fibronectin type-III 2.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity	p.S279C(2)		breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				AGATCGGGTGGATGCTGTGTC	0.378000			O		hepatocellular ca								4	48					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2026919	2026919	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:2026919G>A	ENST00000262113.4	+	12	1508	c.1367G>A	c.(1366-1368)cGa>cAa	p.R456Q	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	456	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TACATATTCCGAGTGAGGGCA	0.522000													26	120					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762964	130762964	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:130762964C>G	ENST00000392429.1	+	2	3775	c.1397C>G	c.(1396-1398)tCt>tGt	p.S466C	TMEM200A_ENST00000545622.1_Missense_Mutation_p.S466C|TMEM200A_ENST00000296978.3_Missense_Mutation_p.S466C	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	466						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ATTTCAAGATCTCACAATAAT	0.348000													17	39					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61026747	61026747	+	Silent	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:61026747G>T	ENST00000335613.5	-	20	2654	c.2268C>A	c.(2266-2268)tcC>tcA	p.S756S	VWCE_ENST00000535710.1_Silent_p.S221S	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	756						extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TTCCGTGAGGGGAGAGCCCCT	0.582000													14	27					1.5842e-08	1.70898e-08	1	1	0
CNNM3	26505	broad.mit.edu	37	2	97498337	97498337	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:97498337G>A	ENST00000305510.3	+	8	2136	c.2108G>A	c.(2107-2109)cGg>cAg	p.R703Q	ANKRD23_ENST00000476975.1_5'UTR|CNNM3_ENST00000377060.3_Missense_Mutation_p.R655Q	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	703					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						AGCCCTGGGCGGAACCCAGGC	0.597000													14	83					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	49039230	49039230	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:49039230C>T	ENST00000267163.4	+	22	2446	c.2308C>T	c.(2308-2310)Cag>Tag	p.Q770*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	770	Domain B.|Interaction with LIMD1.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(12)|p.L769fs*2(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAATATTTTGCAGTATGCTTC	0.323000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			17	33					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310294	24310294	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:24310294T>G	ENST00000357002.4	+	4	1607	c.1492T>G	c.(1492-1494)Tct>Gct	p.S498A	ZNF254_ENST00000342944.6_Missense_Mutation_p.S413A	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	498					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATGTGGCAAATCTTTTAGCCA	0.408000													6	148					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108382902	108382902	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:108382902C>G	ENST00000265843.4	-	6	3442	c.3332G>C	c.(3331-3333)aGa>aCa	p.R1111T	EXPH5_ENST00000443411.1_Missense_Mutation_p.R923T|EXPH5_ENST00000525344.1_Missense_Mutation_p.R1104T|EXPH5_ENST00000428840.1_Missense_Mutation_p.R1035T	NM_015065.2	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5	1111					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGGTCCTTTTCTAACGGAAGT	0.473000													19	66					0	0	1	0	0
MIS18BP1	55320	broad.mit.edu	37	14	45696960	45696960	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:45696960T>A	ENST00000310806.4	-	9	2110	c.1652A>T	c.(1651-1653)cAc>cTc	p.H551L		NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1	551					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						GCAATTACTGTGGCACATGTT	0.343000													7	73					0	0	1	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775472	27775472	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:27775472G>A	ENST00000377401.2	-	1	237	c.213C>T	c.(211-213)ttC>ttT	p.F71F		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	71					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						CGATGCGCTCGAAGATGTCGT	0.602000													15	164					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67047198	67047198	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:67047198A>T	ENST00000340001.4	-	2	281	c.70T>A	c.(70-72)Tgg>Agg	p.W24R	ABCA9_ENST00000453985.2_Missense_Mutation_p.W24R|ABCA9_ENST00000370732.2_Missense_Mutation_p.W24R|ABCA9_ENST00000495634.1_Missense_Mutation_p.W24R	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	24					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTCATTCTCCATTTTTTGAGA	0.378000													6	54					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39265803	39265803	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:39265803C>T	ENST00000280481.7	+	1	4538	c.4322C>T	c.(4321-4323)aCa>aTa	p.T1441I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1441					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACTCTTACAACAGACCTACTA	0.463000													15	67					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41565575	41565575	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr22:41565575A>G	ENST00000263253.7	+	26	5460	c.4241A>G	c.(4240-4242)tAt>tGt	p.Y1414C	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1414					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1414C(1)		NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						ACTGCAGTCTATCATGAAATC	0.333000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				37	84					0	0	1	0	0
TUFT1	7286	broad.mit.edu	37	1	151537068	151537068	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:151537068C>G	ENST00000368849.3	+	5	454	c.392C>G	c.(391-393)tCt>tGt	p.S131C	TUFT1_ENST00000353024.3_Missense_Mutation_p.S72C|TUFT1_ENST00000368848.2_Missense_Mutation_p.S106C|TUFT1_ENST00000392712.3_Intron|TUFT1_ENST00000538902.1_Missense_Mutation_p.S150C	NM_020127.2	NP_064512.1	Q9NNX1	TUFT1_HUMAN	tuftelin 1	131					bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTAGGAGATTCTCTCCATCGA	0.527000													4	31					0	0	1	0	0
LYPD6	130574	broad.mit.edu	37	2	150294289	150294289	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:150294289G>A	ENST00000334166.4	+	2	324	c.67G>A	c.(67-69)Gct>Act	p.A23T	LYPD6_ENST00000409381.1_Missense_Mutation_p.A23T	NM_194317.3	NP_919298.1	Q86Y78	LYPD6_HUMAN	LY6/PLAUR domain containing 6	23						extracellular region				large_intestine(1)|lung(4)	5				BRCA - Breast invasive adenocarcinoma(221;0.0667)		TCTGAAAGCTGCTCAGTCCCG	0.493000													14	37					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7177777	7177777	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:7177777G>C	ENST00000406697.1	+	15	2517	c.1889G>C	c.(1888-1890)gGg>gCg	p.G630A	C1S_ENST00000402681.3_Missense_Mutation_p.G463A|C1S_ENST00000328916.3_Missense_Mutation_p.G630A|C1S_ENST00000360817.5_Missense_Mutation_p.G630A			P09871	C1S_HUMAN	complement component 1, s subcomponent	630	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	AGCTGTAAAGGGGACAGTGGT	0.542000													8	99					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763242	77763242	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:77763242A>C	ENST00000521891.2	+	10	4533	c.4085A>C	c.(4084-4086)aAa>aCa	p.K1362T	ZFHX4_ENST00000518282.1_Missense_Mutation_p.K1336T|ZFHX4_ENST00000455469.2_Missense_Mutation_p.K1317T|ZFHX4_ENST00000050961.6_Missense_Mutation_p.K1317T	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1317						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAATGGAATAAAAATAGCAGT	0.423000										HNSCC(33;0.089)			12	24					0	0	1	0	0
IFNE	338376	broad.mit.edu	37	9	21481245	21481245	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:21481245C>T	ENST00000448696.3	-	1	1067	c.449G>A	c.(448-450)aGg>aAg	p.R150K	MIR31HG_ENST00000304425.3_RNA	NM_176891.4	NP_795372.1	Q86WN2	IFNE_HUMAN	interferon, epsilon	150					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(2)|lung(1)|skin(1)	4						ATCATGGATCCTTCGGAAGTA	0.443000													24	179					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72838591	72838591	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:72838591G>C	ENST00000293190.5	-	13	3831	c.3685C>G	c.(3685-3687)Ctg>Gtg	p.L1229V		NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	1229					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TCTGACTCCAGACTGGAGATC	0.602000													5	13					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													3	49					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	64					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101553314	101553314	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:101553314G>A	ENST00000370449.4	+	4	453	c.340G>A	c.(340-342)Gtt>Att	p.V114I	ABCC2_ENST00000496621.1_3'UTR|ABCC2_ENST00000370434.1_Missense_Mutation_p.V114I	NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	114						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCAGCTCCTGGTTTTGCTGAT	0.463000													9	53					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135099198	135099198	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:135099198G>A	ENST00000409645.1	+	8	1097	c.845G>A	c.(844-846)gGa>gAa	p.G282E	MGAT5_ENST00000281923.2_Missense_Mutation_p.G282E			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	282					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		AAGGAATCTGGATTTAAGATT	0.438000													9	74					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61039961	61039961	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:61039961G>A	ENST00000252997.2	-	7	1186	c.1125C>T	c.(1123-1125)gcC>gcT	p.A375A		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	375					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GGGGGCTTGGGGCCGTGGAGG	0.672000													4	24					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807790	20807790	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:20807790G>A	ENST00000601440.1	-	4	1039	c.893C>T	c.(892-894)tCa>tTa	p.S298L	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						AGTAAGGGTTGAGGACCGGTT	0.383000													28	145					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133750303	133750303	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:133750303G>A	ENST00000318560.5	+	7	1515	c.1134G>A	c.(1132-1134)aaG>aaA	p.K378K		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	378	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding	p.?(1)		breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	ACTTGGTGAAGGTAGCTGATT	0.542000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								6	77					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	154996991	154996991	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:154996991G>T	ENST00000392825.3	+	4	851	c.284G>T	c.(283-285)aGa>aTa	p.R95I	GALNT13_ENST00000409237.1_Missense_Mutation_p.R95I	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	95						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						GCCCTTAATAGAAGTCTGCCA	0.328000													5	42					0.184627	0.185807	1	1	0
FYN	2534	broad.mit.edu	37	6	112041147	112041147	+	Silent	SNP	A	A	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:112041147A>C	ENST00000354650.3	-	4	714	c.108T>G	c.(106-108)ccT>ccG	p.P36P	FYN_ENST00000229471.4_Silent_p.P36P|FYN_ENST00000229470.5_Silent_p.P36P|FYN_ENST00000356013.2_Silent_p.P36P|FYN_ENST00000368678.4_Silent_p.P36P|FYN_ENST00000538466.1_Silent_p.P36P|FYN_ENST00000368682.3_Silent_p.P36P|FYN_ENST00000368667.2_Silent_p.P36P	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	36					axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGTAGTGCTGAGGGGTGGGGT	0.567000													6	33					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033774	79033774	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:79033774C>T	ENST00000446378.2	+	2	9217	c.9186C>T	c.(9184-9186)aaC>aaT	p.N3062N		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3062						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTGATTATAACATCTCCCCAG	0.338000													6	47					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14865418	14865418	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:14865418C>T	ENST00000282096.4	+	12	2719	c.2366C>T	c.(2365-2367)tCg>tTg	p.S789L	PDE3B_ENST00000455098.2_Missense_Mutation_p.S738L	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	789	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TATATTTCTTCGAAGAGCTGC	0.393000													49	111					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57892220	57892220	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:57892220A>C	ENST00000262027.5	+	9	1039	c.905A>C	c.(904-906)cAg>cCg	p.Q302P	MARS_ENST00000447721.2_3'UTR|MARS_ENST00000315473.5_Missense_Mutation_p.Q68P	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	302					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CGCCTCCGCCAGTGGAACACC	0.587000													5	23					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230738	147230738	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:147230738C>T	ENST00000271348.2	-	2	770	c.609G>A	c.(607-609)gaG>gaA	p.E203E	GJA5_ENST00000369237.1_Silent_p.E203E	NM_005266.5	NP_005257.2	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	203					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			AGACATTCTTCTCTGTGGGCC	0.557000													5	39					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20523143	20523143	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:20523143C>T	ENST00000359062.3	+	1	965	c.925C>T	c.(925-927)Cgg>Tgg	p.R309W	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	309					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CAAGTCCCATCGGAGGACCTC	0.587000													7	18					0	0	1	0	0
TRMT2B	79979	broad.mit.edu	37	X	100275492	100275492	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:100275492C>G	ENST00000338687.7	-	10	1822	c.1017G>C	c.(1015-1017)tgG>tgC	p.W339C	TRMT2B_ENST00000545398.1_Missense_Mutation_p.W384C|TRMT2B_ENST00000372935.1_Missense_Mutation_p.W384C|TRMT2B_ENST00000372931.5_Missense_Mutation_p.W384C|TRMT2B_ENST00000372936.3_Missense_Mutation_p.W384C|TRMT2B_ENST00000372939.1_Missense_Mutation_p.W339C			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	384							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						AGGCTGCAGTCCATCTTGCAT	0.473000													19	156					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49737991	49737991	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:49737991C>T	ENST00000327697.6	+	14	1341	c.1197C>T	c.(1195-1197)ggC>ggT	p.G399G	RNF123_ENST00000432042.1_Silent_p.G253G	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	399						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CAGACCTGGGCCTACAGGTGG	0.587000													6	85					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70819875	70819875	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:70819875C>T	ENST00000358731.4	+	25	5760	c.5497C>T	c.(5497-5499)Cat>Tat	p.H1833Y	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1833					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAGGAGAAGTCATAAAAAGTT	0.428000													7	54					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151798408	151798408	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:151798408C>T	ENST00000356728.6	-	1	159	c.5G>A	c.(4-6)aGa>aAa	p.R2K	RORC_ENST00000392697.3_Intron|RORC_ENST00000318247.6_Intron	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	0	Modulating (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCACTTACTTCTCATGACTGA	0.642000													8	77					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377882	18377882	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:18377882C>T	ENST00000392413.4	-	3	683	c.468G>A	c.(466-468)acG>acA	p.T156T	KIAA1683_ENST00000600328.3_Silent_p.T156T|KIAA1683_ENST00000600359.3_Silent_p.T110T	NM_001145304.1	NP_001138776.1	Q9H0B3	K1683_HUMAN	KIAA1683							mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CCTCCGCCCTCGTTTTCTTTA	0.582000													5	31					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628939	51628939	+	Silent	SNP	C	C	T	rs147990048	by1000genomes	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:51628939C>T	ENST00000440804.3	+	2	574	c.507C>T	c.(505-507)gcC>gcT	p.A169A	SIGLEC9_ENST00000250360.3_Silent_p.A169A	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	169	Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		TGCCCTGGGCCTGTGAGCAGG	0.657000													33	55					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77664333	77664333	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:77664333G>A	ENST00000407578.2	-	60	10699	c.10433C>T	c.(10432-10434)tCa>tTa	p.S3478L	MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S3440L|MYCBP2_ENST00000357337.6_Missense_Mutation_p.S3440L	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCAACAACTGAGTATGATCT	0.383000													10	51					0	0	1	0	0
ZNF610	162963	broad.mit.edu	37	19	52852449	52852449	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:52852449G>A	ENST00000601151.1	+	3	476	c.24G>A	c.(22-24)caG>caA	p.Q8Q	ZNF610_ENST00000321287.8_Silent_p.Q8Q|ZNF610_ENST00000403906.3_Silent_p.Q8Q|ZNF610_ENST00000327920.8_Silent_p.Q8Q	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AAGAAGCCCAGAAGAGGAAAG	0.433000													6	68					0	0	1	0	0
FAM78A	286336	broad.mit.edu	37	9	134136632	134136632	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:134136632G>A	ENST00000372271.3	-	2	796	c.429C>T	c.(427-429)acC>acT	p.T143T	FAM78A_ENST00000247295.4_5'UTR|FAM78A_ENST00000372269.3_Silent_p.T140T	NM_033387.3	NP_203745.2	Q5JUQ0	FA78A_HUMAN	family with sequence similarity 78, member A	143										NS(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		GGCCCACGATGGTGCAGGTCT	0.602000													12	34					0	0	1	0	0
OTUB1	55611	broad.mit.edu	37	11	63764993	63764993	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:63764993G>C	ENST00000541478.1	+	4	948	c.488G>C	c.(487-489)gGa>gCa	p.G163A	OTUB1_ENST00000428192.2_Missense_Mutation_p.G264A|OTUB1_ENST00000543988.1_Missense_Mutation_p.G234A|OTUB1_ENST00000535715.1_Intron|OTUB1_ENST00000543004.1_Missense_Mutation_p.G273A|OTUB1_ENST00000422031.2_Missense_Mutation_p.G301A|OTUB1_ENST00000538426.1_Missense_Mutation_p.G264A			Q96FW1	OTUB1_HUMAN	OTU domain, ubiquitin aldehyde binding 1	264	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	6						TACCGGCCTGGACACTACGAT	0.612000													5	65					0	0	1	0	0
PIGW	284098	broad.mit.edu	37	17	34893709	34893709	+	Missense_Mutation	SNP	G	G	C	rs145509687		TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:34893709G>C	ENST00000592983.1	+	2	1339	c.759G>C	c.(757-759)ttG>ttC	p.L253F	MYO19_ENST00000590081.1_Intron|PIGW_ENST00000328396.2_Missense_Mutation_p.L253F			Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class W	253					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CACTGCTGTTGATTATTTTTC	0.353000													10	86					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5469793	5469793	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:5469793G>A	ENST00000282908.5	+	11	1524	c.1102G>A	c.(1102-1104)Gag>Aag	p.E368K	STK32B_ENST00000508728.1_3'UTR|STK32B_ENST00000512636.1_Missense_Mutation_p.E291K|STK32B_ENST00000510398.1_Missense_Mutation_p.E321K	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	368							ATP binding|metal ion binding|protein serine/threonine kinase activity	p.E368K(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						ATTCAACAGAGAGAAGTAAGT	0.522000													15	43					0	0	1	0	0
LAX1	54900	broad.mit.edu	37	1	203743172	203743172	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:203743172C>T	ENST00000442561.2	+	5	950	c.560C>T	c.(559-561)tCa>tTa	p.S187L	LAX1_ENST00000367217.5_Missense_Mutation_p.S171L|LAX1_ENST00000367215.1_3'UTR	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	187					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGCATTTCTTCAGAGGATTCG	0.493000													7	68					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	64					0	0	1	0	0
DUSP9	1852	broad.mit.edu	37	X	152914728	152914728	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:152914728G>A	ENST00000342782.3	+	3	680	c.415G>A	c.(415-417)Gag>Aag	p.E139K	DUSP9_ENST00000370167.4_Missense_Mutation_p.E139K			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	139	Rhodanese.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCACCTGTGTGAGACCAGCCT	0.687000													4	48					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102923	168102923	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:168102923A>C	ENST00000409195.1	+	9	5110	c.5021A>C	c.(5020-5022)aAg>aCg	p.K1674T	XIRP2_ENST00000409273.1_Missense_Mutation_p.K1452T|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.K1674T|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1499					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGATCTGTAAAGAAAGGCATC	0.333000													11	40					0	0	1	0	0
DDAH1	23576	broad.mit.edu	37	1	85790515	85790515	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:85790515C>G	ENST00000284031.8	-	5	743	c.649G>C	c.(649-651)Gac>Cac	p.D217H	DDAH1_ENST00000539042.1_Missense_Mutation_p.D217H|RP11-131L23.1_ENST00000426125.1_RNA|RP11-131L23.1_ENST00000427819.1_RNA|DDAH1_ENST00000542148.1_Missense_Mutation_p.D117H|DDAH1_ENST00000483110.1_5'UTR|DDAH1_ENST00000426972.3_Missense_Mutation_p.D124H|DDAH1_ENST00000535924.2_Missense_Mutation_p.D114H	NM_012137.3	NP_036269.1	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	217					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|skin(1)	5				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	GCTGCTATGTCATCAGGCACA	0.443000													13	36					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141116514	141116514	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:141116514G>C	ENST00000389484.3	-	73	12104	c.11133C>G	c.(11131-11133)gtC>gtG	p.V3711V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3711	LDL-receptor class A 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAAGAAATTTGACTGAAGAAA	0.368000										TSP Lung(27;0.18)			8	70					0	0	1	0	0
DIEXF	27042	broad.mit.edu	37	1	210012290	210012290	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:210012290C>T	ENST00000491415.2	+	7	1156	c.1099C>T	c.(1099-1101)Cgg>Tgg	p.R367W		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	367					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						AGCTGCTTTGCGGGTGGTGCA	0.502000													4	133					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55846894	55846894	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr16:55846894A>T	ENST00000422046.2	-	9	1285	c.1004T>A	c.(1003-1005)cTt>cAt	p.L335H	CES1_ENST00000360526.3_Missense_Mutation_p.L336H|CES1_ENST00000361503.4_Missense_Mutation_p.L335H			P23141	EST1_HUMAN	carboxylesterase 1	335					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TTCAGCTTGAAGCTCTTCAGG	0.507000													14	58					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52557053	52557053	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:52557053G>A	ENST00000321725.6	+	63	6999	c.6923G>A	c.(6922-6924)cGa>cAa	p.R2308Q		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2308					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GTGGCCTGCCGATGCCGAAAT	0.592000													17	86					0	0	1	0	0
ADGRG6	57211	broad.mit.edu	37	6	142764631	142764631	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:142764631C>T	ENST00000367609.3	+	25	4133	c.3732C>T	c.(3730-3732)ttC>ttT	p.F1244F	GPR126_ENST00000367608.2_Silent_p.F1216F|GPR126_ENST00000296932.8_3'UTR|GPR126_ENST00000230173.6_3'UTR	NM_198569.2	NP_940971	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	0					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CAGACACCTTCAGCCACAGCA	0.358000													11	58					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132560865	132560865	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:132560865A>G	ENST00000265342.7	-	10	1538	c.1289T>C	c.(1288-1290)aTt>aCt	p.I430T	FSTL4_ENST00000507112.1_5'UTR	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	430						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGTCTTCAATGAAGAGCGA	0.512000													15	57					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10355147	10355147	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:10355147C>G	ENST00000377086.1	+	18	1796	c.1594C>G	c.(1594-1596)Cca>Gca	p.P532A	KIF1B_ENST00000263934.6_Missense_Mutation_p.P486A|KIF1B_ENST00000377083.1_Missense_Mutation_p.P486A|KIF1B_ENST00000377081.1_Missense_Mutation_p.P532A|KIF1B_ENST00000377093.4_Missense_Mutation_p.P486A			O60333	KIF1B_HUMAN	kinesin family member 1B	532					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TTTTCAGACCCCACATCTTGT	0.428000													12	67					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55525819	55525819	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr16:55525819G>C	ENST00000219070.4	+	8	1796	c.1287G>C	c.(1285-1287)aaG>aaC	p.K429N	MMP2_ENST00000543485.1_Missense_Mutation_p.K353N|MMP2_ENST00000570308.1_Missense_Mutation_p.K353N|MMP2_ENST00000437642.2_Missense_Mutation_p.K379N	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	429	Collagenase-like 2.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CCTACACCAAGAACTTCCGTC	0.622000													6	29					0	0	1	0	0
AKR1B1	231	broad.mit.edu	37	7	134135634	134135634	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:134135634C>G	ENST00000285930.4	-	3	334	c.255G>C	c.(253-255)gaG>gaC	p.E85D	AKR1B1_ENST00000489022.1_5'UTR	NM_001628.2	NP_001619.1	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1 (aldose reductase)	85					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			kidney(1)|large_intestine(5)|lung(2)|ovary(3)|prostate(1)|skin(2)	14					NADH(DB00157)|Sulindac(DB00605)	CCAGGCCCTTCTCATGGTACG	0.552000													5	24					0	0	1	0	0
HOXA6	3203	broad.mit.edu	37	7	27187114	27187114	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:27187114G>A	ENST00000222728.3	-	1	279	c.255C>T	c.(253-255)ctC>ctT	p.L85L	HOXA6_ENST00000521478.1_5'UTR|RP1-170O19.22_ENST00000467897.2_RNA|HOXA-AS3_ENST00000518947.2_RNA|RP1-170O19.23_ENST00000498652.1_RNA|HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000521231.1_RNA	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	85						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						AGGCGCCACTGAGGTCCTTAT	0.617000													6	38					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27169490	27169490	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:27169490C>T	ENST00000380036.4	+	4	933	c.491C>T	c.(490-492)tCa>tTa	p.S164L	TEK_ENST00000519097.1_Missense_Mutation_p.S60L|TEK_ENST00000406359.4_Missense_Mutation_p.S164L	NM_000459.3	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	164					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.S164L(1)		breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TTCATCCATTCAGTGCCCCGG	0.483000													34	228					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236839531	236839531	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:236839531G>C	ENST00000304032.8	+	12	2027	c.1447G>C	c.(1447-1449)Gag>Cag	p.E483Q	AGAP1_ENST00000409538.1_Intron|AGAP1_ENST00000336665.5_Intron|AGAP1_ENST00000428334.2_Missense_Mutation_p.E322Q	NM_001037131.2	NP_001032208.1	Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1		PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCAGTGGAGTGAGGCTACGGT	0.622000													10	26					0	0	1	0	0
C1QA	712	broad.mit.edu	37	1	22965814	22965814	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:22965814G>A	ENST00000374642.3	+	3	856	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	C1QA_ENST00000402322.1_Missense_Mutation_p.E218K	NM_015991.2	NP_057075.1	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	218	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				autonomic_ganglia(1)|liver(1)|lung(3)|skin(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGTCTGGGTTGAAAAAGACCC	0.592000													18	22					0	0	1	0	0
GPAA1	8733	broad.mit.edu	37	8	145138314	145138314	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:145138314G>C	ENST00000355091.4	+	3	398	c.277G>C	c.(277-279)Gaa>Caa	p.E93Q	GPAA1_ENST00000527144.1_3'UTR|GPAA1_ENST00000361036.6_Missense_Mutation_p.E33Q	NM_003801.3	NP_003792.1	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment 1	93					attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(2)	19	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCCTGGCTTGAACGGACGAT	0.632000													11	46					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28419166	28419166	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:28419166G>T	ENST00000394835.3	+	21	4407	c.4215G>T	c.(4213-4215)aaG>aaT	p.K1405N	EFCAB5_ENST00000320856.5_Missense_Mutation_p.K1281N|RP11-1148O4.2_ENST00000582938.1_RNA|EFCAB5_ENST00000394832.2_Intron	NM_198529.3	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1405							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GTTGGGATAAGTGTAAATTTG	0.338000													3	25					0.004672	0.00482518	1	1	0
ARSG	22901	broad.mit.edu	37	17	66381224	66381224	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:66381224G>C	ENST00000448504.2	+	9	1798	c.1002G>C	c.(1000-1002)caG>caC	p.Q334H	ARSG_ENST00000452479.2_Missense_Mutation_p.Q170H|ARSG_ENST00000582154.1_3'UTR	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	334					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAGCCAAGCAGACGACCTGGG	0.557000													9	27					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33785224	33785224	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr18:33785224C>T	ENST00000261326.5	+	6	1224	c.1203C>T	c.(1201-1203)atC>atT	p.I401I		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	401					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	AAGGGAACATCATTGGTTACT	0.473000													11	68					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633293	116633293	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:116633293C>G	ENST00000260210.4	-	4	1035	c.1012G>C	c.(1012-1014)Gac>Cac	p.D338H	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	338										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TGCTTCTTGTCTCCAAAATGG	0.433000													7	86					0	0	1	0	0
ELMO2	63916	broad.mit.edu	37	20	45000485	45000485	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:45000485C>T	ENST00000372176.1	-	17	1744	c.1276G>A	c.(1276-1278)Gag>Aag	p.E426K	ELMO2_ENST00000445496.2_Missense_Mutation_p.E331K|ELMO2_ENST00000352077.2_Missense_Mutation_p.E512K|ELMO2_ENST00000454865.2_Missense_Mutation_p.E246K|ELMO2_ENST00000439931.2_Missense_Mutation_p.E526K|ELMO2_ENST00000396391.1_Missense_Mutation_p.E514K|ELMO2_ENST00000290246.6_Missense_Mutation_p.E514K			Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	514	ELMO.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				CTCATCCTCTCAGACTGGCGC	0.537000													15	53					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55846893	55846893	+	Silent	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr16:55846893A>T	ENST00000422046.2	-	9	1286	c.1005T>A	c.(1003-1005)ctT>ctA	p.L335L	CES1_ENST00000360526.3_Silent_p.L336L|CES1_ENST00000361503.4_Silent_p.L335L			P23141	EST1_HUMAN	carboxylesterase 1	335					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TTTCAGCTTGAAGCTCTTCAG	0.512000													14	58					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41827041	41827041	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr15:41827041C>G	ENST00000304330.4	-	6	750	c.634G>C	c.(634-636)Ggg>Cgg	p.G212R	RPAP1_ENST00000561603.1_Missense_Mutation_p.G212R	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	212						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AGCCCCTTCCCTGTGACCAGA	0.577000													10	36					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497010	1497010	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:1497010G>A	ENST00000421627.2	+	2	285	c.151G>A	c.(151-153)Ggg>Agg	p.G51R		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	130					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CTGCCCCGGGGGGCGCCACCG	0.746000													3	3					0	0	1	0	0
TUBB2B	347733	broad.mit.edu	37	6	3227722	3227722	+	Splice_Site	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:3227722T>A	ENST00000259818.7	-	1	247	c.56A>T	c.(55-57)aAg>aTg	p.K19M	TUBB2B_ENST00000473006.1_Intron	NM_178012.4	NP_821080.1	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B class IIb	19					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			kidney(2)|large_intestine(5)|lung(1)|prostate(1)|skin(1)	10	Ovarian(93;0.0386)	all_hematologic(90;0.108)				CGCGCCCACCTTGGCGCCGAT	0.726000													6	40					0	0	1	0	0
ATG4D	84971	broad.mit.edu	37	19	10657877	10657877	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:10657877G>C	ENST00000309469.4	+	5	956	c.783G>C	c.(781-783)gaG>gaC	p.E261D	ATG4D_ENST00000540862.1_Intron	NM_032885.4	NP_116274.3	Q86TL0	ATG4D_HUMAN	autophagy related 4D, cysteine peptidase	261					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	19			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			AAGCCGTGGAGAGCTGCTCCG	0.652000													3	13					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135099183	135099183	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:135099183T>A	ENST00000409645.1	+	8	1082	c.830T>A	c.(829-831)cTg>cAg	p.L277Q	MGAT5_ENST00000281923.2_Missense_Mutation_p.L277Q			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	277					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CTGGGACTCCTGACCAAGGAA	0.423000													8	70					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148059511	148059511	+	Silent	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:148059511G>T	ENST00000370460.2	+	17	3932	c.3453G>T	c.(3451-3453)ggG>ggT	p.G1151G	AFF2_ENST00000370457.5_Silent_p.G1116G|AFF2_ENST00000286437.5_Silent_p.G792G|AFF2_ENST00000342251.3_Silent_p.G1118G	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	1151					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCGGATGGGGACAAAAAGC	0.418000													19	167					4.96729e-08	5.30406e-08	1	1	0
LRP1	4035	broad.mit.edu	37	12	57591393	57591393	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:57591393G>A	ENST00000243077.3	+	58	9694	c.9228G>A	c.(9226-9228)gtG>gtA	p.V3076V		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3076					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGACAGATGTGACCACCCAGG	0.587000													9	50					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70065826	70065826	+	RNA	SNP	T	T	C	rs3169319	by1000genomes	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr16:70065826T>C	ENST00000531894.1	-	0	796					NR_003610.1													p.M209V(4)									GATCCAAACATAGTGTTACAG	0.453000													3	52					0	0	1	0	0
HSPA12A	259217	broad.mit.edu	37	10	118434610	118434610	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:118434610C>G	ENST00000369209.3	-	12	1814	c.1710G>C	c.(1708-1710)aaG>aaC	p.K570N		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	570							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		CAGAGATGAACTTGTCAAAGA	0.597000													7	25					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27948977	27948977	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:27948977C>A	ENST00000379992.2	-	6	2142	c.1693G>T	c.(1693-1695)Gtg>Ttg	p.V565L	LINGO2_ENST00000308675.3_Missense_Mutation_p.V565L	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	565						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGCTCCACACAAAAAGGAGA	0.453000													9	61					0.0692343	0.0701248	1	1	0
SQLE	6713	broad.mit.edu	37	8	126015502	126015502	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:126015502G>C	ENST00000265896.5	+	2	1274	c.376G>C	c.(376-378)Gtt>Ctt	p.V126L	SQLE_ENST00000523430.1_Missense_Mutation_p.V31L	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	126					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	TGACCCAGAAGTTATCATCGT	0.433000													6	45					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6648426	6648426	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:6648426G>C	ENST00000299441.3	-	14	6255	c.5844C>G	c.(5842-5844)atC>atG	p.I1948M		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1948	Cadherin 18.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGCGCACCGTGATGGTGACAG	0.612000													15	45					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120413948	120413948	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:120413948G>C	ENST00000602047.1	+	25	2679	c.1567G>C	c.(1567-1569)Gat>Cat	p.D523H	PCDP1_ENST00000413369.3_Missense_Mutation_p.D809H			Q4G0U5	PCDP1_HUMAN		809						cilium	calmodulin binding					Colorectal(110;0.196)					AGAAGTGAAAGATCAAGCACA	0.493000													5	19					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100064246	100064246	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:100064246A>G	ENST00000524871.1	+	15	2025	c.1735A>G	c.(1735-1737)Aaa>Gaa	p.K579E	CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000418526.2_Missense_Mutation_p.K505E|CNTN5_ENST00000527185.1_Missense_Mutation_p.K579E|CNTN5_ENST00000528682.1_Missense_Mutation_p.K579E|CNTN5_ENST00000279463.3_Missense_Mutation_p.K579E	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	579	Ig-like C2-type 6.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACTTACTCCTAAAAGAACAGA	0.333000													3	14					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7221241	7221241	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:7221241G>A	ENST00000575474.1	-	5	511	c.512C>T	c.(511-513)tCa>tTa	p.S171L	NEURL4_ENST00000315614.7_Silent_p.F1355F|NEURL4_ENST00000574120.1_5'UTR|NEURL4_ENST00000570460.1_Silent_p.F1333F|NEURL4_ENST00000399464.2_Silent_p.F1357F																							GCGGAGGCATGAAATAATCTT	0.612000													13	40					0	0	1	0	0
DNAAF3	352909	broad.mit.edu	37	19	55672736	55672736	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:55672736G>A	ENST00000527223.2	-	7	919	c.918C>T	c.(916-918)gtC>gtT	p.V306V	CTD-2587H24.5_ENST00000591665.1_RNA|DNAAF3_ENST00000455045.1_Silent_p.V184V|DNAAF3_ENST00000391720.4_Silent_p.V285V|DNAAF3_ENST00000524407.2_Silent_p.V238V	NM_001256714.1	NP_001243643	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	238																	GTTCAAAGGCGACGCCTGTGT	0.662000													5	10					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156639892	156639892	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:156639892G>C	ENST00000368223.3	-	4	4220	c.4088C>G	c.(4087-4089)tCt>tGt	p.S1363C		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1363	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGACAGGTCAGAGTCACGGCC	0.632000													3	68					0	0	1	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238680748	238680748	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:238680748G>A	ENST00000308482.9	+	21	1603	c.1534G>A	c.(1534-1536)Gag>Aag	p.E512K	LRRFIP1_ENST00000468950.1_3'UTR	NM_001137550.1	NP_001131022.1	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	563	DNA-binding.				negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		AGGGCAGCTGGAGGAGAGACA	0.418000													10	17					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77193698	77193698	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr18:77193698G>A	ENST00000253506.5	+	3	1715	c.1346G>A	c.(1345-1347)gGg>gAg	p.G449E	NFATC1_ENST00000329101.4_Missense_Mutation_p.G436E|NFATC1_ENST00000427363.2_Missense_Mutation_p.G449E|NFATC1_ENST00000542384.1_Missense_Mutation_p.G449E|NFATC1_ENST00000318065.5_Missense_Mutation_p.G436E|NFATC1_ENST00000592223.1_Missense_Mutation_p.G436E|NFATC1_ENST00000587635.1_Missense_Mutation_p.G449E|NFATC1_ENST00000591814.1_Missense_Mutation_p.G449E|NFATC1_ENST00000397790.2_5'UTR|NFATC1_ENST00000545796.1_5'UTR|NFATC1_ENST00000586434.1_Missense_Mutation_p.G436E	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	449	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GGCAGCCGGGGGGCCGTGAAG	0.632000													15	42					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73476281	73476281	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:73476281G>C	ENST00000539919.1	+	9	1185	c.814G>C	c.(814-816)Gag>Cag	p.E272Q	CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000540468.1_Missense_Mutation_p.E229Q|CCT7_ENST00000538797.1_Missense_Mutation_p.E188Q|CCT7_ENST00000537131.1_Missense_Mutation_p.E216Q|CCT7_ENST00000398422.2_Missense_Mutation_p.E112Q|CCT7_ENST00000258091.5_Missense_Mutation_p.E316Q	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	316					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						CCGAGTACCTGAGGAGGATCT	0.517000													4	44					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226079	39226079	+	Nonsense_Mutation	SNP	C	C	A	rs150567366	byFrequency	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:39226079C>A	ENST00000340369.3	-	2	5086	c.4858G>T	c.(4858-4860)Gag>Tag	p.E1620*	XIRP1_ENST00000396251.1_3'UTR|XIRP1_ENST00000421646.1_Nonsense_Mutation_p.E303*	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1620							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTCTGGGCCTCAGTGTGGCAT	0.562000													31	91					5.77227e-19	6.44775e-19	1	1	0
NCKIPSD	51517	broad.mit.edu	37	3	48716386	48716386	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:48716386G>A	ENST00000294129.2	-	11	1835	c.1716C>T	c.(1714-1716)gtC>gtT	p.V572V	NCKIPSD_ENST00000341520.4_Silent_p.V572V|NCKIPSD_ENST00000416649.2_Silent_p.V565V	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	572	Leu-rich.				cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CAGCCATGATGACATTCTGGT	0.597000													5	102					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53392723	53392723	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:53392723G>A	ENST00000226067.5	+	3	1060	c.587G>A	c.(586-588)cGc>cAc	p.R196H	HLF_ENST00000575345.1_Missense_Mutation_p.R111H|HLF_ENST00000430986.2_Missense_Mutation_p.R111H|HLF_ENST00000573945.1_Missense_Mutation_p.R111H	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	196	Pro-rich (proline/acidic region (PAR)).				multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R196H(1)		large_intestine(1)|ovary(2)	3						TTTGACCCTCGCAAACGCAAG	0.517000			T	TCF3	ALL								10	41					0	0	1	0	0
ZFP30	22835	broad.mit.edu	37	19	38127148	38127148	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:38127148C>G	ENST00000351218.2	-	6	851	c.294G>C	c.(292-294)atG>atC	p.M98I	ZFP30_ENST00000392144.1_Missense_Mutation_p.M98I|ZFP30_ENST00000589018.1_Intron|ZFP30_ENST00000514101.2_Missense_Mutation_p.M98I	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGATAAGTTCATTTCATAAA	0.343000													16	80					0	0	1	0	0
CKS1B	1163	broad.mit.edu	37	1	154947386	154947386	+	Silent	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:154947386G>C	ENST00000368439.1	+	1	258	c.9G>C	c.(7-9)acG>acC	p.T3T	CKS1B_ENST00000368436.1_Intron|CKS1B_ENST00000308987.5_Intron			P61024	CKS1_HUMAN	CDC28 protein kinase regulatory subunit 1B	0					cell division|cell proliferation|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	nucleoplasm	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)|large_intestine(1)|lung(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCATGCGTACGAGGTGCGAAC	0.567000													12	79					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68139440	68139440	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:68139440T>C	ENST00000262215.3	-	27	4237	c.3848A>G	c.(3847-3849)cAt>cGt	p.H1283R	ARFGEF1_ENST00000518230.1_Missense_Mutation_p.H121R|ARFGEF1_ENST00000520381.1_Missense_Mutation_p.H737R	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1283					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGCAGCTAGATGAAATACAGA	0.398000													56	54					0	0	1	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775463	27775463	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:27775463G>C	ENST00000377401.2	-	1	246	c.222C>G	c.(220-222)atC>atG	p.I74M		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	74					nucleosome assembly	nucleosome|nucleus	DNA binding	p.I74I(1)		cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						CCTCGCTTGCGATGCGCTCGA	0.612000													43	114					0	0	1	0	0
MEGF9	1955	broad.mit.edu	37	9	123384995	123384995	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:123384995G>C	ENST00000373930.3	-	3	953	c.842C>G	c.(841-843)tCt>tGt	p.S281C	MEGF9_ENST00000426959.1_Missense_Mutation_p.S318C	NM_001080497.2	NP_001073966.2	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	281	Laminin EGF-like 2.					integral to membrane	calcium ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	16						GTCACATATAGAGCCAATGAC	0.408000													4	46					0	0	1	0	0
PRAM1	84106	broad.mit.edu	37	19	8562693	8562693	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:8562693C>T	ENST00000423345.4	-	4	2051	c.1531G>A	c.(1531-1533)Gat>Aat	p.D511N	PRAM1_ENST00000255612.3_Missense_Mutation_p.D510N			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	559	Pro-rich.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						GGTTCCACATCGTCATACAGC	0.498000													7	40					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033772	79033772	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:79033772A>T	ENST00000446378.2	+	2	9215	c.9184A>T	c.(9184-9186)Aac>Tac	p.N3062Y		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3062						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GATTGATTATAACATCTCCCC	0.343000													6	49					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72021644	72021644	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:72021644G>A	ENST00000378743.3	-	21	4375	c.4017C>T	c.(4015-4017)taC>taT	p.Y1339Y		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1339					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CATTTGTAAAGTATCTGACAT	0.368000													9	33					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64675047	64675047	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:64675047G>T	ENST00000421419.2	-	18	2711	c.2597C>A	c.(2596-2598)tCa>tAa	p.S866*	ATG2A_ENST00000377264.3_Nonsense_Mutation_p.S866*			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	866							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CCAGAAGCCTGAGGGGCCGGG	0.627000													4	4					0.150653	0.152102	1	1	0
PROX1	5629	broad.mit.edu	37	1	214170364	214170364	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:214170364G>A	ENST00000366958.4	+	2	1094	c.486G>A	c.(484-486)ctG>ctA	p.L162L	PROX1_ENST00000261454.4_Silent_p.L162L|PROX1_ENST00000498508.2_Silent_p.L162L|PROX1_ENST00000435016.1_Silent_p.L162L	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	162					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		ATGAGCACCTGAGAGCAAAGC	0.522000													11	56					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36122831	36122831	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr22:36122831G>A	ENST00000249044.2	+	3	716	c.716G>A	c.(715-717)gGc>gAc	p.G239D		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	239					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						GCTATCCAGGGCATCAAGGAT	0.468000													4	148					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119673229	119673229	+	Splice_Site	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:119673229T>G	ENST00000371322.5	-	12	1698		c.e12-2		CUL4B_ENST00000404115.3_Splice_Site|CUL4B_ENST00000336592.6_Splice_Site	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B						cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CATACTTAGCTAAAATGGGGG	0.343000													6	32					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218959	130218959	+	Silent	SNP	A	A	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:130218959A>C	ENST00000276211.5	+	7	1221	c.876A>C	c.(874-876)gcA>gcC	p.A292A	ARHGAP36_ENST00000370922.1_Silent_p.A280A|ARHGAP36_ENST00000370921.1_Silent_p.A156A	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	292	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						ATGTGGCTGCACTCCTCAAGG	0.473000													23	134					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43618481	43618481	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:43618481G>C	ENST00000292246.3	-	6	1035	c.865C>G	c.(865-867)Cat>Gat	p.H289D	ANO10_ENST00000414522.2_Missense_Mutation_p.H289D|ANO10_ENST00000350459.4_Intron|ANO10_ENST00000451430.2_Missense_Mutation_p.H178D|ANO10_ENST00000396091.3_Missense_Mutation_p.H223D	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	289					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						AAGACACCATGAAATCCTGGC	0.537000													6	68					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49084658	49084658	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:49084658C>T	ENST00000395443.2	-	4	1832	c.1360G>A	c.(1360-1362)Gaa>Aaa	p.E454K	QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000424300.1_Missense_Mutation_p.E454K|QRICH1_ENST00000357496.2_Missense_Mutation_p.E454K	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	454	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGTTCAACTTCAGCAACCTGG	0.413000													10	77					0	0	1	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833314	27833314	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:27833314C>T	ENST00000357320.2	+	1	281	c.182C>T	c.(181-183)gCc>gTc	p.A61V		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	61					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						TACCTGACTGCCGAGATCCTG	0.687000													11	95					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158326666	158326666	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:158326666C>A	ENST00000444681.2	+	5	1143	c.850C>A	c.(850-852)Cgc>Agc	p.R284S	CD1E_ENST00000368155.3_Missense_Mutation_p.R226S|CD1E_ENST00000368154.1_Missense_Mutation_p.R139S|CD1E_ENST00000368165.3_Missense_Mutation_p.R293S|CD1E_ENST00000368164.3_3'UTR|CD1E_ENST00000368163.3_Missense_Mutation_p.R316S|CD1E_ENST00000368160.3_Missense_Mutation_p.R371S|CD1E_ENST00000368161.3_3'UTR|CD1E_ENST00000368167.3_Missense_Mutation_p.R383S|CD1E_ENST00000368166.3_Missense_Mutation_p.R182S|CD1E_ENST00000368157.1_Missense_Mutation_p.R127S|CD1E_ENST00000368156.1_Missense_Mutation_p.R281S|CD1E_ENST00000452291.2_Missense_Mutation_p.R194S	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	383	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen		p.R383C(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GTGGAAGACACGCCTAAACCA	0.428000													4	45					0.014758	0.0150934	1	1	0
PARP14	54625	broad.mit.edu	37	3	122419063	122419063	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:122419063C>T	ENST00000474629.2	+	6	1928	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GGAAAGAATTCTCTAAGTGTC	0.398000													3	19					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107978024	107978024	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:107978024C>T	ENST00000372129.2	-	1	1627	c.1551G>A	c.(1549-1551)tcG>tcA	p.S517S		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	517						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GGTTTCCTCCCGAGCTATGGC	0.597000													19	99					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38120937	38120937	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:38120937G>C	ENST00000395867.3	-	6	1896	c.1346C>G	c.(1345-1347)tCa>tGa	p.S449*	ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Nonsense_Mutation_p.S449*	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						AGTGAGGTTTGACTTCACACA	0.458000													18	119					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7318929	7318929	+	Silent	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:7318929C>G	ENST00000302926.2	+	6	1210	c.1137C>G	c.(1135-1137)ctC>ctG	p.L379L	NLGN2_ENST00000575301.1_Silent_p.L379L	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	379					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				ACGACATGCTCATCGGCGTCA	0.592000													5	55					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150445215	150445215	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:150445215G>C	ENST00000401000.4	+	10	3778	c.3713G>C	c.(3712-3714)gGa>gCa	p.G1238A	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.G1264A			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1264	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GAGCACAGTGGAATTCCTTTC	0.617000													6	44					0	0	1	0	0
MSS51	118490	broad.mit.edu	37	10	75185861	75185861	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:75185861C>T	ENST00000299432.2	-	5	842	c.777G>A	c.(775-777)agG>agA	p.R259R	MSS51_ENST00000372912.1_Silent_p.R259R	NM_001024593.1	NP_001019764.1	Q4VC12	ZMY17_HUMAN	MSS51 mitochondrial translational activator	259							zinc ion binding										TTCCCCCAGTCCTCCTAACAT	0.542000													5	37					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60781470	60781470	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:60781470C>T	ENST00000313421.7	+	8	1557	c.1371C>T	c.(1369-1371)atC>atT	p.I457I	CD6_ENST00000545105.1_3'UTR|CD6_ENST00000352009.5_Intron|CD6_ENST00000452451.2_Silent_p.I457I|CD6_ENST00000346437.4_Intron|CD6_ENST00000344028.5_Intron	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	457					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						CGGTCCCCATCACCATCCCCA	0.597000													4	21					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49249238	49249238	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:49249238A>T	ENST00000438782.1	+	2	261	c.25A>T	c.(25-27)Aaa>Taa	p.K9*	CCDC36_ENST00000366429.2_Nonsense_Mutation_p.K9*|CCDC36_ENST00000296449.5_Nonsense_Mutation_p.K9*|CCDC36_ENST00000452691.2_Nonsense_Mutation_p.K9*|CCDC36_ENST00000493870.1_Intron			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	9										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CTGGAATATCAAAGAGATGCT	0.343000													15	109					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59620470	59620470	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:59620470T>C	ENST00000257264.3	-	9	1384	c.1280A>G	c.(1279-1281)gAg>gGg	p.E427G		NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	427					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCAGCGAACCTCCAAGTTTTC	0.408000													33	150					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135311030	135311030	+	Missense_Mutation	SNP	G	G	C	rs148213320		TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:135311030G>C	ENST00000285968.6	+	33	4740	c.4714G>C	c.(4714-4716)Gag>Cag	p.E1572Q		NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1572					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GGGTGCATTAGAGCTGCTAAG	0.468000													13	90					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935582	151935582	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:151935582G>A	ENST00000393902.3	-	3	1152	c.585C>T	c.(583-585)atC>atT	p.I195I	MAGEA3_ENST00000370278.3_Silent_p.I195I			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	195	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTGGGCATGATCTGATTGT	0.567000													19	164					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34091550	34091550	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:34091550C>G	ENST00000297161.2	+	9	1128	c.754C>G	c.(754-756)Ctg>Gtg	p.L252V	BMPER_ENST00000494786.1_3'UTR|BMPER_ENST00000426693.1_Missense_Mutation_p.L252V	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	252	VWFC 4.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ATCCTCATTTCTGTACGATAA	0.473000													11	50					0	0	1	0	0
TBL1X	6907	broad.mit.edu	37	X	9684283	9684283	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:9684283G>A	ENST00000217964.7	+	18	2371	c.1731G>A	c.(1729-1731)aaG>aaA	p.K577K	TBL1X_ENST00000536365.1_Silent_p.K526K|TBL1X_ENST00000407597.2_Silent_p.K577K|TBL1X_ENST00000424279.1_Silent_p.K526K|TBL1X_ENST00000380961.1_Silent_p.K526K	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	577					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				ATCTGCGGAAGTAACCACAAA	0.403000													5	18					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	50					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25399840	25399840	+	Silent	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:25399840C>G	ENST00000255324.5	+	16	2227	c.2175C>G	c.(2173-2175)ctC>ctG	p.L725L	RNF17_ENST00000381921.1_Silent_p.L725L	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	725					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TGGAAATCCTCTGTCCAGTTC	0.373000													14	69					0	0	1	0	0
MAPRE2	10982	broad.mit.edu	37	18	32650241	32650241	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr18:32650241G>A	ENST00000436190.2	+	3	443	c.169G>A	c.(169-171)Gac>Aac	p.D57N	MAPRE2_ENST00000413393.1_Missense_Mutation_p.D26N|MAPRE2_ENST00000589699.1_Missense_Mutation_p.D26N|MAPRE2_ENST00000588910.1_Missense_Mutation_p.D69N|MAPRE2_ENST00000538170.2_Intron|MAPRE2_ENST00000300249.5_Missense_Mutation_p.D69N	NM_001143827.2	NP_001137299.1	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family, member 2	69	CH.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9						ATGGGTTAATGACATAGTATC	0.358000													6	68					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895324	90895324	+	Missense_Mutation	SNP	G	G	A	rs143614174		TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:90895324G>A	ENST00000287934.2	+	1	1542	c.1129G>A	c.(1129-1131)Gac>Aac	p.D377N		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	377					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCTCCTGGAAGACCGAGTGGT	0.622000													7	70					0	0	1	0	0
MGEA5	10724	broad.mit.edu	37	10	103551118	103551118	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:103551118C>G	ENST00000361464.3	-	13	2649	c.2254G>C	c.(2254-2256)Gga>Cga	p.G752R	MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000357797.5_Missense_Mutation_p.G685R|MGEA5_ENST00000439817.1_Missense_Mutation_p.G699R	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	752	Histone acetyltransferase activity (By similarity).|Required for histone H4 binding (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TACTTGTCTCCAATAAGATCA	0.373000													6	41					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603088	140603088	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:140603088G>A	ENST00000239449.4	+	1	11	c.11G>A	c.(10-12)aGa>aAa	p.R4K	PCDHB14_ENST00000515856.2_5'UTR	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		4					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGAGATCAGAGGGGCACTC	0.468000													17	49					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50140128	50140128	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:50140128G>C	ENST00000371564.3	-	2	871	c.652C>G	c.(652-654)Cca>Gca	p.P218A	NFATC2_ENST00000396009.3_Missense_Mutation_p.P218A|NFATC2_ENST00000609507.1_5'UTR|NFATC2_ENST00000414705.1_Missense_Mutation_p.P198A|NFATC2_ENST00000610033.1_5'UTR|NFATC2_ENST00000609943.1_Missense_Mutation_p.P198A	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	218	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GACATTATTGGCGAGGTTCTG	0.652000													4	85					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122820835	122820835	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:122820835G>T	ENST00000264811.5	-	9	2678	c.2260C>A	c.(2260-2262)Cag>Aag	p.Q754K	TRPC3_ENST00000379645.3_Missense_Mutation_p.Q827K|TRPC3_ENST00000513531.1_Missense_Mutation_p.Q699K	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	742					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GAGTTAGACTGAGTGAAGAGG	0.308000													12	57					7.03913e-09	7.64595e-09	1	1	0
FBN2	2201	broad.mit.edu	37	5	127627252	127627252	+	Silent	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:127627252A>G	ENST00000508053.1	-	55	7235	c.6261T>C	c.(6259-6261)ttT>ttC	p.F2087F	FBN2_ENST00000262464.4_Silent_p.F2087F			P35556	FBN2_HUMAN	fibrillin 2	2087	EGF-like 35; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAGATAGTACAAAGCCAGGGG	0.428000													13	57					0	0	1	0	0
FBXW8	26259	broad.mit.edu	37	12	117365827	117365827	+	Splice_Site	SNP	G	G	A	rs141082626		TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:117365827G>A	ENST00000455858.2	+	2	193		c.e2-1		FBXW8_ENST00000309909.5_Splice_Site	NM_012174.1|NM_153348.2	NP_036306.1|NP_699179.2	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8								protein binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	22	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		TTTCCCCTCAGAATGAAATGA	0.323000													6	41					0	0	1	0	0
MBD4	8930	broad.mit.edu	37	3	129155869	129155869	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:129155869G>C	ENST00000429544.2	-	3	813	c.618C>G	c.(616-618)aaC>aaG	p.N206K	MBD4_ENST00000503197.1_Missense_Mutation_p.N206K|MBD4_ENST00000507208.1_Missense_Mutation_p.N206K|MBD4_ENST00000249910.1_Missense_Mutation_p.N206K|MBD4_ENST00000509587.1_Intron|MBD4_ENST00000393278.2_Intron	NM_001276270.1	NP_001263199.1	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	206					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)	22						TGGAAGTAAAGTTAGAGAGTC	0.418000								Base excision repair (BER), DNA glycosylases					14	113					0	0	1	0	0
DDX26B	203522	broad.mit.edu	37	X	134683629	134683629	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:134683629C>G	ENST00000370752.4	+	7	1139	c.805C>G	c.(805-807)Cat>Gat	p.H269D	DDX26B_ENST00000481908.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	269										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					GCATAGTTGTCATAAACTCAT	0.393000													43	281					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152000	123152000	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:123152000G>T	ENST00000466202.1	-	2	971	c.395C>A	c.(394-396)aCa>aAa	p.T132K	IQUB_ENST00000324698.6_Missense_Mutation_p.T132K|IQUB_ENST00000488987.1_Intron|IQUB_ENST00000434450.1_Missense_Mutation_p.T132K	NM_001282855.1	NP_001269784.1	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	132	Ubiquitin-like.									breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						GGTAGTACCTGTTGCTAGAGA	0.328000													5	50					0.0215528	0.0219004	1	1	0
OR2A14	135941	broad.mit.edu	37	7	143826316	143826316	+	Silent	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:143826316C>A	ENST00000408899.2	+	1	166	c.111C>A	c.(109-111)acC>acA	p.T37T		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					ATACACTCACCCTGCTGGGGA	0.498000													9	80					0.000442599	0.000461652	1	1	0
GTF3C4	9329	broad.mit.edu	37	9	135554247	135554247	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:135554247A>G	ENST00000372146.4	+	2	1805	c.1241A>G	c.(1240-1242)cAc>cGc	p.H414R	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	414					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		CTGAATGTTCACAATTCCCAT	0.463000													20	71					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83838959	83838959	+	Silent	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:83838959C>G	ENST00000349129.2	+	16	2333	c.2073C>G	c.(2071-2073)ctC>ctG	p.L691L	DOPEY1_ENST00000369739.3_Silent_p.L682L|DOPEY1_ENST00000237163.5_Silent_p.L672L	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	691					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTATCAACCTCTACATCATTC	0.443000													12	61					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41205790	41205790	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:41205790G>A	ENST00000399959.2	+	14	2385	c.1530G>A	c.(1528-1530)gtG>gtA	p.V510V	DDX3X_ENST00000542215.1_3'UTR|DDX3X_ENST00000457138.2_Silent_p.V494V|DDX3X_ENST00000441189.2_Intron|DDX3X_ENST00000478993.1_3'UTR	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	510	Helicase C-terminal.|Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						TTTCAAATGTGAAACATGTTA	0.353000										HNSCC(61;0.18)			7	111					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90461176	90461176	+	Silent	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:90461176T>C	ENST00000369393.3	-	23	3316	c.3201A>G	c.(3199-3201)agA>agG	p.R1067R	MDN1_ENST00000428876.1_Silent_p.R1067R			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1067					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGACTATATCTCTCAGGTTCA	0.483000													7	35					0	0	1	0	0
TARS2	80222	broad.mit.edu	37	1	150463906	150463906	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:150463906G>A	ENST00000438568.2	+	4	464	c.424G>A	c.(424-426)Gat>Aat	p.D142N	TARS2_ENST00000606933.1_Silent_p.R183R|TARS2_ENST00000369054.2_Silent_p.R183R|TARS2_ENST00000369064.3_Silent_p.R183R			Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	644					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TTTTGGAGCGGATTTGCCAGG	0.562000													10	55					0	0	1	0	0
FECH	2235	broad.mit.edu	37	18	55247287	55247287	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr18:55247287C>G	ENST00000382873.3	-	2	245	c.212G>C	c.(211-213)aGg>aCg	p.R71T	FECH_ENST00000262093.5_Intron|FECH_ENST00000585699.1_Intron			P22830	HEMH_HUMAN	ferrochelatase	65			I -> K (in EPP; enzyme totally inactive).		generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	15		Colorectal(73;0.227)				TTATTTGTACCTGATGTTAGA	0.498000													7	110					0	0	1	0	0
ANXA1	301	broad.mit.edu	37	9	75773638	75773638	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:75773638C>G	ENST00000376911.1	+	2	976	c.94C>G	c.(94-96)Ccc>Gcc	p.P32A	ANXA1_ENST00000257497.6_Missense_Mutation_p.P32A			P04083	ANXA1_HUMAN	annexin A1	32					alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(5)	8		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CAAAGGTGGTCCCGGATCAGC	0.393000													7	38					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57484229	57484229	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:57484229G>C	ENST00000371100.4	+	7	3024	c.2472G>C	c.(2470-2472)aaG>aaC	p.K824N	GNAS_ENST00000371095.3_Missense_Mutation_p.K167N|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000265620.7_Missense_Mutation_p.K166N|GNAS_ENST00000306090.10_Missense_Mutation_p.K167N|GNAS_ENST00000354359.7_Missense_Mutation_p.K182N|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371085.3_Missense_Mutation_p.K181N|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000371102.4_Missense_Mutation_p.K810N	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	181					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TCCTGGACAAGATCGACGTGA	0.512000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			32	231					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184290795	184290795	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:184290795G>A	ENST00000330394.2	+	3	1139	c.687G>A	c.(685-687)gcG>gcA	p.A229A	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	229	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TCACTGGGGCGGAGCCCACCT	0.637000													9	41					0	0	1	0	0
STOML2	30968	broad.mit.edu	37	9	35102696	35102696	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:35102696C>T	ENST00000356493.5	-	2	232	c.170G>A	c.(169-171)cGg>cAg	p.R57Q	STOML2_ENST00000452248.2_Missense_Mutation_p.R57Q	NM_013442.1	NP_038470.1	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	57						cytoskeleton	receptor binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	16			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTCCAGGATCCGGTGGAATCG	0.637000													32	87					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130863464	130863464	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:130863464G>A	ENST00000373066.5	+	2	716	c.309G>A	c.(307-309)ctG>ctA	p.L103L	SLC25A25_ENST00000373069.5_Silent_p.L117L|SLC25A25_ENST00000373068.2_Silent_p.L117L|SLC25A25_ENST00000373064.5_Silent_p.L83L|SLC25A25_ENST00000432073.2_Silent_p.L103L|SLC25A25_ENST00000433501.1_5'UTR	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	83	EF-hand 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						AGAAGAAGCTGAGGCTGGTGT	0.478000													11	47					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072524	240072524	+	Nonstop_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:240072524G>C	ENST00000255380.4	+	5	2552	c.1773G>C	c.(1771-1773)taG>taC	p.*591Y		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	0					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	AGGCCTTGTAGAATGAGGTTG	0.512000													6	32					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67592071	67592071	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:67592071C>T	ENST00000521381.1	+	15	2503	c.1887C>T	c.(1885-1887)agC>agT	p.S629S	PIK3R1_ENST00000320694.8_Silent_p.S329S|PIK3R1_ENST00000274335.5_Silent_p.S629S|PIK3R1_ENST00000336483.5_Silent_p.S359S|PIK3R1_ENST00000521657.1_Silent_p.S629S|PIK3R1_ENST00000396611.1_Silent_p.S637S|PIK3R1_ENST00000523872.1_Silent_p.S266S	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	629	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTGGAAGCAGCAACCGAAACA	0.478000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			15	88					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671503	39671503	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr21:39671503G>A	ENST00000328656.4	+	4	623	c.320G>A	c.(319-321)tGc>tAc	p.C107Y	KCNJ15_ENST00000398938.2_Missense_Mutation_p.C107Y|KCNJ15_ENST00000398934.1_Missense_Mutation_p.C107Y|KCNJ15_ENST00000398930.1_Missense_Mutation_p.C107Y|KCNJ15_ENST00000398932.1_Missense_Mutation_p.C107Y	NM_001276437.1|NM_001276438.1|NM_001276439.1|NM_002243.3	NP_001263366.1|NP_001263367.1|NP_001263368.1|NP_002234.2	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15						synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						CATACCCCCTGCATCATGAAA	0.483000													29	74					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388554	56388554	+	Silent	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:56388554G>C	ENST00000355701.3	-	19	3972	c.3102C>G	c.(3100-3102)ccC>ccG	p.P1034P	BZRAP1_ENST00000268893.6_Silent_p.P974P|BZRAP1_ENST00000343736.4_Silent_p.P1034P	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1034	Fibronectin type-III 3.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGCCTGCCGTGGGTGAGGCCA	0.652000													3	12					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212190365	212190365	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:212190365C>T	ENST00000366994.3	-	4	476	c.372G>A	c.(370-372)cgG>cgA	p.R124R	INTS7_ENST00000366993.3_Splice_Site_p.R124R|INTS7_ENST00000440600.2_Splice_Site_p.G75G|INTS7_ENST00000366992.3_Splice_Site_p.R124R|INTS7_ENST00000469606.1_5'UTR	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	124					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TTCCCAACATCCTACAGAAAC	0.373000													17	65					0	0	1	0	0
CCSER2	54462	broad.mit.edu	37	10	86133500	86133500	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:86133500G>A	ENST00000224756.8	+	3	1728	c.1543G>A	c.(1543-1545)Gaa>Aaa	p.E515K	CCSER2_ENST00000359979.4_Missense_Mutation_p.E515K|CCSER2_ENST00000372088.2_Missense_Mutation_p.E515K	NM_001284243.1|NM_018999.2	NP_001271172.1|NP_061872.2			coiled-coil serine-rich protein 2																		CATGTGGGATGAAGAAGGCTT	0.413000													9	57					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	367734	367734	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:367734A>T	ENST00000256509.2	+	4	826	c.184A>T	c.(184-186)Aat>Tat	p.N62Y	CHL1_ENST00000397491.2_Missense_Mutation_p.N62Y	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	62	Ig-like C2-type 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGCTAAAGGAAATCCAGAACC	0.373000													4	29					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80561989	80561989	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:80561989T>G	ENST00000424301.2	+	11	1410	c.1172T>G	c.(1171-1173)gTc>gGc	p.V391G	CKMT2-AS1_ENST00000511495.1_RNA|CKMT2_ENST00000254035.4_Missense_Mutation_p.V391G|CKMT2_ENST00000437669.1_Missense_Mutation_p.V391G|CKMT2-AS1_ENST00000503483.2_RNA|CKMT2-AS1_ENST00000505295.1_RNA|CKMT2-AS1_ENST00000512287.1_RNA|CKMT2-AS1_ENST00000500148.2_RNA|CKMT2-AS1_ENST00000502041.2_RNA|CKMT2-AS1_ENST00000501927.2_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	391	Phosphagen kinase C-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	ATCGATGGAGTCAATTACCTG	0.418000													17	130					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	711201	711201	+	Silent	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:711201A>G	ENST00000382303.1	+	7	1087	c.435A>G	c.(433-435)ccA>ccG	p.P145P	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_5'UTR|KANK1_ENST00000382297.2_Silent_p.P145P	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	145					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CTCCCTCACCACAACTCCCAA	0.522000													21	50					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22237159	22237159	+	RNA	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:22237159C>A	ENST00000390428.3	+	0	243																											CGACAAGATCCAGGAAGAGGC	0.448000													10	36					2.74318e-10	3.01081e-10	1	1	0
CTTN	2017	broad.mit.edu	37	11	70266505	70266505	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:70266505G>C	ENST00000301843.8	+	10	885		c.e10-1		CTTN_ENST00000376561.3_Splice_Site|CTTN_ENST00000346329.3_Splice_Site	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin							cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TGTGCATGTAGACTATGTGAA	0.438000													4	29					0	0	1	0	0
TDO2	6999	broad.mit.edu	37	4	156831287	156831287	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:156831287G>T	ENST00000536354.2	+	6	606	c.542G>T	c.(541-543)cGt>cTt	p.R181L		NM_005651.3	NP_005642.1	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	181					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	18	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	AGACATTATCGTGATAACTTC	0.368000													8	71					2.17888e-05	2.28782e-05	1	1	0
ARRDC4	91947	broad.mit.edu	37	15	98513969	98513969	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr15:98513969C>T	ENST00000268042.6	+	7	1360	c.1196C>T	c.(1195-1197)tCa>tTa	p.S399L	ARRDC4_ENST00000538249.1_Missense_Mutation_p.S312L	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	399					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			CCTCTTTATTCAGAGGTAAGC	0.393000													9	77					0	0	1	0	0
KIAA1009	22832	broad.mit.edu	37	6	84925077	84925077	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:84925077C>G	ENST00000403245.3	-	5	540	c.426G>C	c.(424-426)ttG>ttC	p.L142F	KIAA1009_ENST00000257766.4_Missense_Mutation_p.L66F	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	142					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TGGAAGATGTCAAGCCTTTCT	0.353000													5	15					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135102577	135102577	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:135102577G>A	ENST00000409645.1	+	9	1306	c.1054G>A	c.(1054-1056)Gat>Aat	p.D352N	MGAT5_ENST00000281923.2_Missense_Mutation_p.D352N			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	352					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CATTTACATTGATATTGTAGG	0.423000													18	149					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27459801	27459801	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:27459801C>T	ENST00000375946.4	+	8	2516	c.1913C>T	c.(1912-1914)cCt>cTt	p.P638L	MASTL_ENST00000375940.4_Missense_Mutation_p.P638L|MASTL_ENST00000477034.1_3'UTR|MASTL_ENST00000342386.6_Missense_Mutation_p.P638L	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	638	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATGTTAGGTCCTCCTTTGGAG	0.403000													12	55					0	0	1	0	0
IFNE	338376	broad.mit.edu	37	9	21481244	21481244	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:21481244C>A	ENST00000448696.3	-	1	1068	c.450G>T	c.(448-450)agG>agT	p.R150S	MIR31HG_ENST00000304425.3_RNA	NM_176891.4	NP_795372.1	Q86WN2	IFNE_HUMAN	interferon, epsilon	150					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(2)|lung(1)|skin(1)	4						AATCATGGATCCTTCGGAAGT	0.443000													24	177					1.64293e-13	1.82227e-13	1	1	0
GPRC5D	55507	broad.mit.edu	37	12	13103184	13103184	+	Silent	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:13103184G>C	ENST00000228887.1	-	1	134	c.135C>G	c.(133-135)ctC>ctG	p.L45L	RP11-392P7.6_ENST00000394742.3_RNA|RP11-392P7.6_ENST00000543515.2_RNA|RP11-392P7.6_ENST00000545914.1_RNA|RP11-392P7.6_ENST00000542078.1_RNA|RP11-392P7.6_ENST00000540198.1_RNA|GPRC5D_ENST00000396333.3_Silent_p.L45L|RP11-392P7.6_ENST00000536029.1_RNA	NM_018654.1	NP_061124.1	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5, member D	45						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(2)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GCATGAGGAAGAGAAATGCTA	0.542000													9	49					0	0	1	0	0
ASIC3	9311	broad.mit.edu	37	7	150749714	150749714	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:150749714C>A	ENST00000357922.4	+	10	2106	c.1512C>A	c.(1510-1512)caC>caA	p.H504Q	ASIC3_ENST00000349064.5_Missense_Mutation_p.T524N|ASIC3_ENST00000297512.8_Missense_Mutation_p.P531T	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	500					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										TCCCACCGCACCTGCTACCTT	0.622000													16	61					1.5739e-10	1.73957e-10	1	1	0
GUCY2C	2984	broad.mit.edu	37	12	14766207	14766207	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:14766207C>G	ENST00000261170.3	-	27	3202	c.3066G>C	c.(3064-3066)ttG>ttC	p.L1022F	RP11-695J4.2_ENST00000545424.1_RNA|RP11-695J4.2_ENST00000542401.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1022					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ATTCTGCTTGCAAACGCTGTT	0.413000													30	155					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66430871	66430871	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:66430871G>T	ENST00000383703.3	-	20	3632	c.3029C>A	c.(3028-3030)tCc>tAc	p.S1010Y	LRIG1_ENST00000273261.3_Missense_Mutation_p.S1033Y|SLC25A26_ENST00000536651.1_3'UTR|LRIG1_ENST00000496559.2_5'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	1033						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TAGCTCTGTGGAGTCCGGGTG	0.527000													15	139					3.27435e-08	3.52021e-08	1	1	0
OPTN	10133	broad.mit.edu	37	10	13151272	13151272	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:13151272G>T	ENST00000378748.3	+	4	512	c.150G>T	c.(148-150)gaG>gaT	p.E50D	OPTN_ENST00000378747.3_Missense_Mutation_p.E50D|OPTN_ENST00000378752.3_Missense_Mutation_p.E50D|OPTN_ENST00000378757.2_Missense_Mutation_p.E50D|OPTN_ENST00000263036.5_Missense_Mutation_p.E50D|OPTN_ENST00000378764.2_Missense_Mutation_p.E50D|OPTN_ENST00000482140.1_3'UTR	NM_001008211.1|NM_001008213.1	NP_001008212|NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	50			E -> K (in GLC1E; dbSNP:rs28939688).		cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22						TCCTGACCGAGAACCACCAGC	0.592000													6	34					3.59834e-05	3.7657e-05	1	1	0
CLVS2	134829	broad.mit.edu	37	6	123319254	123319254	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:123319254T>C	ENST00000275162.5	+	2	1667	c.332T>C	c.(331-333)cTg>cCg	p.L111P	CLVS2_ENST00000368438.1_Intron	NM_001010852.3	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2		CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						CTGGCCAATCTGGACCACTAT	0.502000													10	58					0	0	1	0	0
BZW1	9689	broad.mit.edu	37	2	201677975	201677975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:201677975C>A	ENST00000409600.1	+	2	490	c.35C>A	c.(34-36)tCa>tAa	p.S12*	BZW1_ENST00000452790.2_Nonsense_Mutation_p.S44*|BZW1_ENST00000409226.1_Nonsense_Mutation_p.S16*	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						CCAACGCTATCAGGCCAGCGT	0.353000													12	40					5.50884e-06	5.80362e-06	1	1	0
ERCC6L2	375748	broad.mit.edu	37	9	98774955	98774955	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:98774955G>A	ENST00000407474.3	+	4	1579	c.1066G>A	c.(1066-1068)Gca>Aca	p.A356T				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	0					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										AAACAGCCAGGCATCCGAAGA	0.408000													6	31					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32306218	32306218	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:32306218C>T	ENST00000302418.4	-	24	3071	c.2614G>A	c.(2614-2616)Gag>Aag	p.E872K	KIF5B_ENST00000493889.1_5'UTR	NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	872					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				TTCACTCTCTCAGCTGTAGCT	0.428000			T	"""RET, ALK"""	NSCLC								14	73					0	0	1	0	0
PGM5P2	595135	broad.mit.edu	37	9	69112895	69112895	+	RNA	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:69112895G>C	ENST00000591037.1	-	0	1156					NR_002836.2																						ACCCCCATCTGATGGAAATAT	0.512000													17	54					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95562454	95562454	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:95562454C>G	ENST00000526495.1	-	25	5094	c.4803G>C	c.(4801-4803)aaG>aaC	p.K1601N	DICER1_ENST00000343455.3_Missense_Mutation_p.K1601N|DICER1_ENST00000393063.1_Missense_Mutation_p.K1601N|DICER1_ENST00000541352.1_Missense_Mutation_p.K1601N|DICER1_ENST00000556045.1_Missense_Mutation_p.K499N|DICER1_ENST00000527414.1_Missense_Mutation_p.K1601N			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1601					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GGCACAGGGCCTTTTCCCGAT	0.517000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				56	137					0	0	1	0	0
MGME1	92667	broad.mit.edu	37	20	17950722	17950722	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:17950722G>C	ENST00000377710.5	+	2	508	c.220G>C	c.(220-222)Gaa>Caa	p.E74Q	MGME1_ENST00000377709.1_Missense_Mutation_p.E74Q|MGME1_ENST00000467391.1_3'UTR|MGME1_ENST00000377704.4_Missense_Mutation_p.E74Q	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		ATCGGTGGAGGAAGATGCTTT	0.493000													10	42					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91714218	91714218	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:91714218T>G	ENST00000359028.2	+	35	9033	c.8808T>G	c.(8806-8808)agT>agG	p.S2936R	AKAP9_ENST00000356239.3_Missense_Mutation_p.S2932R|AKAP9_ENST00000358100.2_Intron			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2936					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGAAGAAAGTGAAAGTGCAA	0.368000			T	BRAF	papillary thyroid								9	82					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13717530	13717530	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:13717530T>A	ENST00000265104.4	-	73	12703	c.12599A>T	c.(12598-12600)aAg>aTg	p.K4200M		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4200	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.K4200T(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGCACCGAACTTGCGCCTCTC	0.552000									Kartagener syndrome				8	38					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114261119	114261119	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:114261119C>T	ENST00000545145.2	-	24	2871	c.2793G>A	c.(2791-2793)ccG>ccA	p.P931P	RBM19_ENST00000392561.3_Silent_p.P931P|RBM19_ENST00000261741.5_Silent_p.P931P	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	931					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCTTTTTCTTCGGGGGCTCTG	0.592000													12	27					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25480538	25480538	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:25480538C>G	ENST00000381884.4	-	7	1823	c.1638G>C	c.(1636-1638)atG>atC	p.M546I	CENPJ_ENST00000545981.1_Missense_Mutation_p.M546I	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	546					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CAGACTCTTTCATGGTCTCCC	0.448000													7	59					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984425	41984425	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:41984425C>T	ENST00000333141.5	+	1	713	c.616C>T	c.(616-618)Cag>Tag	p.Q206*		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	206										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						AGGCTTGTCTCAGCAGGTCCT	0.577000													23	125					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3126761	3126761	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr18:3126761C>G	ENST00000356443.4	-	19	3262	c.2929G>C	c.(2929-2931)Gat>Cat	p.D977H	MYOM1_ENST00000261606.7_Missense_Mutation_p.D881H|MYOM1_ENST00000400569.3_Missense_Mutation_p.D977H|MYOM1_ENST00000582016.1_5'UTR	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	977	Fibronectin type-III 4.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GGTACCCCATCAATGACCTCG	0.463000													4	22					0	0	1	0	0
SSTR2	6752	broad.mit.edu	37	17	71165503	71165503	+	Silent	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:71165503A>G	ENST00000357585.2	+	2	414	c.45A>G	c.(43-45)ctA>ctG	p.L15L	SSTR2_ENST00000315332.2_Silent_p.L15L|RP11-143K11.5_ENST00000580671.1_RNA	NM_001050.2	NP_001041.1	P30874	SSR2_HUMAN	somatostatin receptor 2	15					digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity			endometrium(2)|large_intestine(5)|lung(2)|prostate(2)	11			LUSC - Lung squamous cell carcinoma(166;0.197)			ACACATGGCTATCCATTCCAT	0.498000													4	33					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79094996	79094996	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:79094996C>T	ENST00000326724.4	-	11	2764	c.2740G>A	c.(2740-2742)Gat>Aat	p.D914N	AATK_ENST00000417379.1_Missense_Mutation_p.D811N	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	914						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			TAGCCACCATCACTGGCTGAG	0.662000													6	10					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72202048	72202048	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:72202048C>T	ENST00000555818.1	+	20	5474	c.5126C>T	c.(5125-5127)gCt>gTt	p.A1709V	SIPA1L1_ENST00000537413.1_Missense_Mutation_p.A1163V|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.A1688V|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.A1688V	NM_001284247.1|NM_015556.1	NP_001271176.1|NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1709					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCCTTGAGTGCTGCATCCAAC	0.512000													12	86					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121825286	121825286	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:121825286G>A	ENST00000330540.2	+	4	758	c.642G>A	c.(640-642)atG>atA	p.M214I	CD86_ENST00000393627.2_Missense_Mutation_p.M208I|CD86_ENST00000264468.5_Intron|CD86_ENST00000493101.1_Missense_Mutation_p.M102I|CD86_ENST00000469710.1_Missense_Mutation_p.M132I	NM_175862.4	NP_787058	P42081	CD86_HUMAN	CD86 molecule	214	Ig-like C2-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding	p.M214I(1)		breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	CGAGCAATATGACCATCTTCT	0.393000													35	210					0	0	1	0	0
ZFP91	80829	broad.mit.edu	37	11	58377337	58377337	+	Silent	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:58377337T>A	ENST00000316059.6	+	3	576	c.405T>A	c.(403-405)tcT>tcA	p.S135S	ZFP91-CNTF_ENST00000389919.4_Silent_p.S135S	NM_001197051.1|NM_053023.4	NP_001183980.1|NP_444251.1	Q96JP5	ZFP91_HUMAN	ZFP91 zinc finger protein	135					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AAGACGATTCTGCCCTCCCTC	0.438000													4	31					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370747	240370747	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:240370747C>A	ENST00000319653.9	+	5	2865	c.2635C>A	c.(2635-2637)Cca>Aca	p.P879T		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	879	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGTGCCTCCCCCACCTCCCCC	0.597000													11	40					4.68919e-08	5.02413e-08	1	1	0
ZNF626	199777	broad.mit.edu	37	19	20807848	20807848	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:20807848G>A	ENST00000601440.1	-	4	981	c.835C>T	c.(835-837)Cat>Tat	p.H279Y	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TTTTCCGTATGAATTATCTCA	0.383000													34	112					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222803056	222803056	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:222803056G>A	ENST00000344922.5	+	4	2519	c.2494G>A	c.(2494-2496)Gac>Aac	p.D832N	MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344507.1_Intron|MIA3_ENST00000344441.6_Missense_Mutation_p.D832N	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	832					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TGACTTTTCTGACAGCATAAA	0.423000													10	39					0	0	1	0	0
GJA3	2700	broad.mit.edu	37	13	20716832	20716832	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:20716832T>C	ENST00000241125.3	-	2	772	c.596A>G	c.(595-597)gAg>gGg	p.E199G		NM_021954.3	NP_068773.2	Q9Y6H8	CXA3_HUMAN	gap junction protein, alpha 3, 46kDa	199					cell-cell signaling|visual perception	connexon complex|integral to membrane				NS(1)|endometrium(1)|kidney(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		GATGGTCTTCTCCGTGGGCCT	0.607000													6	56					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109707445	109707445	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:109707445G>C	ENST00000356711.2	+	26	3160	c.3034G>C	c.(3034-3036)Gat>Cat	p.D1012H	MYO16_ENST00000457511.2_Missense_Mutation_p.D524H|MYO16_ENST00000357550.2_Missense_Mutation_p.D1012H	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1012	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GGAACGAGGAGATCCAGTCAC	0.338000													10	66					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57258449	57258449	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:57258449G>C	ENST00000343433.6	-	2	117	c.37C>G	c.(37-39)Cga>Gga	p.R13G	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	13										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						AATTTGGCTCGAAGTTCCTTG	0.388000													15	154					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841027	13841027	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:13841027G>C	ENST00000265104.4	-	34	5801	c.5697C>G	c.(5695-5697)atC>atG	p.I1899M		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1899	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.I1899M(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTCATCAAAGATATCCCTTT	0.383000									Kartagener syndrome				6	86					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1279783	1279783	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:1279783G>A	ENST00000381312.1	-	6	1691	c.1366C>T	c.(1366-1368)Cgg>Tgg	p.R456W	ADARB2_ENST00000469464.1_5'UTR	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	456	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		TCCTCGCGCCGCTTGCTAGGG	0.507000													3	45					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848546	215848546	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:215848546C>T	ENST00000366943.2	-	63	13093	c.12707G>A	c.(12706-12708)tGt>tAt	p.C4236Y	USH2A_ENST00000307340.3_Missense_Mutation_p.C4236Y			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4236	Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTATATTCACACTGCGTCCA	0.428000										HNSCC(13;0.011)			6	61					0	0	1	0	0
HPSE2	60495	broad.mit.edu	37	10	100995414	100995414	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:100995414A>G	ENST00000370552.3	-	1	205	c.146T>C	c.(145-147)gTa>gCa	p.V49A	HPSE2_ENST00000370549.1_Missense_Mutation_p.V49A|HPSE2_ENST00000370546.1_Missense_Mutation_p.V49A|HPSE2_ENST00000404542.1_Missense_Mutation_p.V49A	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	49					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		AGCTCTGTCTACAGGCAAGGG	0.572000													14	75					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112437170	112437170	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:112437170A>T	ENST00000230538.7	-	36	5405	c.5008T>A	c.(5008-5010)Ttt>Att	p.F1670I	LAMA4_ENST00000389463.4_Missense_Mutation_p.F1663I|LAMA4_ENST00000424408.2_Missense_Mutation_p.F1663I|LAMA4_ENST00000522006.1_Missense_Mutation_p.F1663I	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1670	Laminin G-like 5.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GCAATTTCAAACTTCAATCCA	0.398000													16	69					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113653034	113653034	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:113653034C>T	ENST00000361127.5	+	13	1846	c.1648C>T	c.(1648-1650)Cgt>Tgt	p.R550C	LRIG2_ENST00000492207.1_3'UTR	NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2		Ig-like C2-type 1.					cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GAATTTTGTTCGTTATTGGCA	0.418000													31	121					0	0	1	0	0
SMPDL3A	10924	broad.mit.edu	37	6	123124961	123124961	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:123124961C>A	ENST00000368440.4	+	5	898	c.721C>A	c.(721-723)Cag>Aag	p.Q241K	SMPDL3A_ENST00000539041.1_Missense_Mutation_p.Q110K	NM_006714.3	NP_006705.1	Q92484	ASM3A_HUMAN	sphingomyelin phosphodiesterase, acid-like 3A	241					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity			breast(1)|cervix(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	10				GBM - Glioblastoma multiforme(226;0.236)		GAACAACTCTCAGCAGAATAA	0.403000													26	77					7.41945e-09	8.03136e-09	1	1	0
C3	718	broad.mit.edu	37	19	6693063	6693063	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:6693063G>C	ENST00000245907.6	-	26	3354	c.3262C>G	c.(3262-3264)Ctg>Gtg	p.L1088V		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1088					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTGACAGCCAGAGAGAAGACC	0.582000													10	76					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35831921	35831921	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:35831921G>T	ENST00000085219.5	+	7	1453	c.1387G>T	c.(1387-1389)Gag>Tag	p.E463*	CD22_ENST00000270311.6_Nonsense_Mutation_p.E343*|CD22_ENST00000594250.1_Nonsense_Mutation_p.E286*|CD22_ENST00000536635.2_Nonsense_Mutation_p.E375*|CD22_ENST00000341773.6_Nonsense_Mutation_p.E286*|CD22_ENST00000544992.2_Nonsense_Mutation_p.E463*|CD22_ENST00000419549.2_Nonsense_Mutation_p.E291*	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	463	Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TGGCGCCTGGGAGGAGCCATC	0.552000													15	77					7.93312e-07	8.41392e-07	1	1	0
GABRG1	2565	broad.mit.edu	37	4	46060510	46060510	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:46060510G>A	ENST00000295452.4	-	6	922	c.755C>T	c.(754-756)aCg>aTg	p.T252M		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	252					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.T252M(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		ACCAGAGATCGTGTGAGTGAT	0.328000													12	38					0	0	1	0	0
C11orf57	55216	broad.mit.edu	37	11	111951297	111951297	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:111951297C>G	ENST00000530104.1	+	4	392	c.335C>G	c.(334-336)tCc>tGc	p.S112C	C11orf57_ENST00000532163.1_Intron|C11orf57_ENST00000393047.3_Intron|C11orf57_ENST00000420986.2_Intron|C11orf57_ENST00000280352.9_Intron			Q6ZUT1	CK057_HUMAN	chromosome 11 open reading frame 57	0										autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		GTGATTAATTCCTGTGAGCAT	0.333000													8	72					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644386	53644386	+	Silent	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:53644386T>A	ENST00000452676.2	-	5	2124	c.1698A>T	c.(1696-1698)ggA>ggT	p.G566G	ZNF347_ENST00000334197.7_Silent_p.G565G|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Silent_p.G566G	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AAGGTTTTTCTCCAGTATGGA	0.408000													4	265					0	0	1	0	0
MEDAG	84935	broad.mit.edu	37	13	31498487	31498487	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:31498487G>C	ENST00000380482.4	+	5	1152	c.827G>C	c.(826-828)aGa>aCa	p.R276T	TEX26-AS1_ENST00000451495.2_RNA|TEX26-AS1_ENST00000593246.1_RNA|TEX26-AS1_ENST00000586464.1_RNA|TEX26-AS1_ENST00000590721.1_RNA|TEX26-AS1_ENST00000586973.1_RNA|TEX26-AS1_ENST00000588726.1_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000588425.1_RNA|TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000585870.1_RNA	NM_032849.3	NP_116238			mesenteric estrogen-dependent adipogenesis																		CTGTCACCCAGATCATCTCTG	0.363000													4	84					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100998654	100998654	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:100998654G>A	ENST00000325455.5	-	1	2601	c.1148C>T	c.(1147-1149)cCc>cTc	p.P383L	PGR_ENST00000263463.5_Missense_Mutation_p.P383L|PGR_ENST00000534013.1_Intron	NM_000926.4|NM_001202474.1|NM_001271162.1	NP_000917.3|NP_001189403.1|NP_001258091.1	P06401	PRGR_HUMAN	progesterone receptor	383	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTTTAGAGCGGGCGGCTGGAA	0.682000													3	21					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9495513	9495513	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:9495513G>C	ENST00000402466.1	+	18	2911	c.2143G>C	c.(2143-2145)Gag>Cag	p.E715Q	SETD5_ENST00000302463.6_Missense_Mutation_p.E715Q|SETD5_ENST00000488236.1_3'UTR|SETD5_ENST00000402198.1_Missense_Mutation_p.E813Q|SETD5_ENST00000406341.1_Missense_Mutation_p.E813Q|SETD5_ENST00000407969.1_Missense_Mutation_p.E832Q			Q9C0A6	SETD5_HUMAN	SET domain containing 5	813										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CCAAAGCAATGAGAATAGTAG	0.378000													6	47					0	0	1	0	0
CA8	767	broad.mit.edu	37	8	61192272	61192272	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:61192272G>A	ENST00000317995.4	-	2	532	c.268C>T	c.(268-270)Cag>Tag	p.Q90*		NM_004056.4	NP_004047.3	P35219	CAH8_HUMAN	carbonic anhydrase VIII	90					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(6)|prostate(2)|skin(1)	16		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				AGGATAACCTGAATGGTATGT	0.418000													17	58					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46472021	46472021	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:46472021G>C	ENST00000361297.2	+	8	1139	c.856G>C	c.(856-858)Gaa>Caa	p.E286Q	MAST2_ENST00000372009.2_Missense_Mutation_p.E286Q	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	286					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					ACCAGATGAGGAAGGACGGCA	0.562000													10	77					0	0	1	0	0
ZFP91	80829	broad.mit.edu	37	11	58377347	58377347	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:58377347C>G	ENST00000316059.6	+	3	586	c.415C>G	c.(415-417)Cag>Gag	p.Q139E	ZFP91-CNTF_ENST00000389919.4_Missense_Mutation_p.Q139E	NM_001197051.1|NM_053023.4	NP_001183980.1|NP_444251.1	Q96JP5	ZFP91_HUMAN	ZFP91 zinc finger protein	139					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				TGCCCTCCCTCAGGAAGTTTC	0.458000													6	33					0	0	1	0	0
SLC31A1	1317	broad.mit.edu	37	9	116021044	116021044	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:116021044G>A	ENST00000374212.4	+	4	425	c.273G>A	c.(271-273)gaG>gaA	p.E91E	CDC26_ENST00000490408.1_Intron|SLC31A1_ENST00000374210.6_Silent_p.E91E	NM_001859.3	NP_001850.1	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporter), member 1	91						integral to plasma membrane	copper ion transmembrane transporter activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7						TAGCCCGAGAGAGCCTGCTGC	0.453000													9	82					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	534286	534286	+	Missense_Mutation	SNP	C	C	G	rs104894228		TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:534286C>G	ENST00000417302.1	-	2	224	c.37G>C	c.(37-39)Ggt>Cgt	p.G13R	HRAS_ENST00000311189.7_Missense_Mutation_p.G13R|HRAS_ENST00000451590.1_Missense_Mutation_p.G13R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397594.1_Missense_Mutation_p.G13R|HRAS_ENST00000397596.2_Missense_Mutation_p.G13R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	13			G -> C (in FCSS).|G -> D (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(70)|p.G13S(9)|p.G13C(8)|p.G12_G13insAG(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			8	14					0	0	1	0	0
RING1	6015	broad.mit.edu	37	6	33179042	33179042	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:33179042C>G	ENST00000374656.4	+	5	771	c.563C>G	c.(562-564)tCa>tGa	p.S188*	RING1_ENST00000478431.1_3'UTR	NM_002931.3	NP_002922.2	Q06587	RING1_HUMAN	ring finger protein 1	188	Necessary for transcriptional repression (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			endometrium(5)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|skin(4)	17						GATGTGAGCTCAGACTCCGCC	0.677000													14	72					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110864216	110864216	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:110864216G>A	ENST00000375820.4	-	7	562	c.441C>T	c.(439-441)ccC>ccT	p.P147P	COL4A1_ENST00000543140.1_Splice_Site_p.P147P	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	147					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding	p.P147P(2)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTCTACTCACGGGATTTCCAG	0.468000													9	177					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101735502	101735502	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:101735502A>G	ENST00000251127.6	-	32	3712	c.3631T>C	c.(3631-3633)Ttt>Ctt	p.F1211L		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1211						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTCTTAAAAAATGGATGCTGG	0.413000													7	47					0	0	1	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482803	152482803	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chrX:152482803A>C	ENST00000356661.5	-	3	426	c.208T>G	c.(208-210)Ttc>Gtc	p.F70V		NM_004988.4	NP_004979.3	P43355	MAGA1_HUMAN	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	70						cytoplasm|plasma membrane				breast(1)|central_nervous_system(7)|kidney(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTCGAGTGAAGTTGATGGTA	0.597000													18	116					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99355818	99355818	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:99355818G>C	ENST00000354593.2	-	8	1103	c.1000C>G	c.(1000-1002)Caa>Gaa	p.Q334E	CYP3A4_ENST00000336411.2_Missense_Mutation_p.Q484E			P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	484					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTTTCTGGTTGAAGAAGTCCT	0.393000													5	99					0	0	1	0	0
ZNF564	163050	broad.mit.edu	37	19	12638698	12638698	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:12638698T>G	ENST00000339282.7	-	4	420	c.224A>C	c.(223-225)aAa>aCa	p.K75T	ZNF709_ENST00000428311.1_Intron|CTD-2192J16.20_ENST00000593682.1_3'UTR	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						ATCATATTCTTTACTTTCACT	0.323000													15	83					0	0	1	0	0
CEACAM7	1087	broad.mit.edu	37	19	42191091	42191091	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:42191091C>T	ENST00000006724.3	-	2	327	c.126G>A	c.(124-126)ccG>ccA	p.P42P	CEACAM7_ENST00000401731.1_Silent_p.P42P|CEACAM7_ENST00000338196.4_Silent_p.P42P|CEACAM7_ENST00000602225.1_Silent_p.P42P|CEACAM7_ENST00000599715.1_5'UTR	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	42	Ig-like V-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		CGACATTGAACGGCACGACAT	0.488000													12	87					0	0	1	0	0
PHF20L1	51105	broad.mit.edu	37	8	133848940	133848940	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:133848940G>C	ENST00000395386.2	+	16	2364	c.2065G>C	c.(2065-2067)Gat>Cat	p.D689H	PHF20L1_ENST00000395390.2_Missense_Mutation_p.D664H|PHF20L1_ENST00000220847.7_Missense_Mutation_p.D76H	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	689							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTGTGAGATGGATGAGGAGAA	0.398000													9	84					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89385009	89385009	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr15:89385009A>G	ENST00000439576.2	+	5	1042	c.668A>G	c.(667-669)gAc>gGc	p.D223G	ACAN_ENST00000352105.7_Missense_Mutation_p.D223G|ACAN_ENST00000559004.1_Missense_Mutation_p.D223G|ACAN_ENST00000561243.1_Missense_Mutation_p.D223G|ACAN_ENST00000558207.1_Missense_Mutation_p.D223G	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	223					cell adhesion		hyaluronic acid binding|sugar binding	p.D223G(2)		NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGCTATGGAGACAAGGATGAG	0.577000													13	68					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37618232	37618232	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr21:37618232C>T	ENST00000399151.3	+	19	4039	c.3954C>T	c.(3952-3954)ctC>ctT	p.L1318L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1318				L -> P (in Ref. 1; CAB41415).	endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TCACCTACCTCTGCCTGAGCT	0.582000													19	62					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756680	124756680	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:124756680G>T	ENST00000306534.3	-	16	2959	c.2474C>A	c.(2473-2475)cCc>cAc	p.P825H	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Missense_Mutation_p.P680H	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	825					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ATAGGTGGTGGGGGGTGAAGG	0.592000													7	64					0.00448238	0.00464457	1	1	0
UBE2O	63893	broad.mit.edu	37	17	74387548	74387548	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:74387548G>C	ENST00000319380.7	-	18	3419	c.3355C>G	c.(3355-3357)Ccc>Gcc	p.P1119A		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1119							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						ACCTCGGGGGGCCGCCGCACC	0.602000													5	80					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120169949	120169949	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:120169949C>G	ENST00000450251.1	+	3	828	c.284C>G	c.(283-285)tCa>tGa	p.S95*	USP53_ENST00000274030.6_Nonsense_Mutation_p.S95*			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	95					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						GCACTTCCCTCAGATAACATA	0.413000													11	82					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17036032	17036032	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:17036032C>G	ENST00000443236.1	-	26	3693	c.3662G>C	c.(3661-3663)aGa>aCa	p.R1221T		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1174						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GGTGGTCTCTCTCTCCACCTC	0.537000													5	47					0	0	1	0	0
LONRF2	164832	broad.mit.edu	37	2	100912009	100912009	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:100912009C>G	ENST00000393437.3	-	8	2122	c.1483G>C	c.(1483-1485)Gca>Cca	p.A495P	LONRF2_ENST00000409647.1_Missense_Mutation_p.A252P	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2	495					proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						TTTCTGCTTGCCAATAACTGT	0.368000													3	48					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000269305.4_Missense_Mutation_p.R280T|TP53_ENST00000445888.2_Missense_Mutation_p.R280T|TP53_ENST00000359597.4_Missense_Mutation_p.R280T	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	17					0	0	1	0	0
TCEB3	6924	broad.mit.edu	37	1	24080918	24080918	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:24080918G>C	ENST00000418390.2	+	7	2108	c.1837G>C	c.(1837-1839)Gat>Cat	p.D613H	TCEB3_ENST00000609199.1_Missense_Mutation_p.D587H	NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	613	Activation domain (By similarity).|F-box.				positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		GTGTACACCTGATCAGCTGTA	0.468000													7	75					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54856731	54856731	+	Silent	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:54856731G>T	ENST00000333896.5	+	13	2806	c.2421G>T	c.(2419-2421)gtG>gtT	p.V807V	SPTBN1_ENST00000356805.4_Silent_p.V820V	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	820					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CTCCAGACGTGAGGGGCAGGC	0.637000													20	51					5.35267e-07	5.69625e-07	1	1	0
DPYD	1806	broad.mit.edu	37	1	98058935	98058935	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:98058935C>T	ENST00000370192.3	-	10	1067	c.967G>A	c.(967-969)Gcc>Acc	p.A323T		NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	323					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity	p.A323P(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GAGTGACAGGCGCACATTCCT	0.453000													5	56					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61102943	61102943	+	Nonsense_Mutation	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:61102943T>A	ENST00000196169.3	+	11	2093	c.1305T>A	c.(1303-1305)taT>taA	p.Y435*	TDRD3_ENST00000535286.1_Nonsense_Mutation_p.Y528*|TDRD3_ENST00000377894.2_Nonsense_Mutation_p.Y435*|TDRD3_ENST00000377881.2_Nonsense_Mutation_p.Y435*	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	435					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CTGTAGATTATAATAATCAAA	0.333000													7	56					0	0	1	0	0
CLNS1A	1207	broad.mit.edu	37	11	77333667	77333667	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:77333667G>A	ENST00000525428.1	-	5	614	c.524C>T	c.(523-525)tCc>tTc	p.S175F	CLNS1A_ENST00000525064.1_Intron|CLNS1A_ENST00000528364.1_Missense_Mutation_p.S175F|CLNS1A_ENST00000263309.3_Missense_Mutation_p.S141F|CLNS1A_ENST00000532069.1_Missense_Mutation_p.S105F	NM_001293.2	NP_001284.1	P54105	ICLN_HUMAN	chloride channel, nucleotide-sensitive, 1A	175					blood circulation|cell volume homeostasis|chloride transport|ncRNA metabolic process|spliceosomal snRNP assembly	cytoskeleton|cytosol|nucleus|plasma membrane	protein binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_cancers(14;5.43e-17)|all_epithelial(13;1.78e-19)		Epithelial(5;1.02e-48)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			TGTTAGATGGGATAATCCTTC	0.403000													11	40					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242192894	242192894	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:242192894C>T	ENST00000391975.1	-	10	1434	c.1207G>A	c.(1207-1209)Gag>Aag	p.E403K	HDLBP_ENST00000310931.4_Missense_Mutation_p.E403K|HDLBP_ENST00000391976.2_Missense_Mutation_p.E403K|HDLBP_ENST00000427183.2_Missense_Mutation_p.E370K	NM_203346.3	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	403	KH 4.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCTTCGCCCTCTGTGAACTCG	0.522000													46	76					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81072495	81072495	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr10:81072495G>C	ENST00000334512.5	+	25	3765	c.3193G>C	c.(3193-3195)Gag>Cag	p.E1065Q	ZMIZ1_ENST00000446377.2_Missense_Mutation_p.E131Q	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	1065					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GTCTCTATTTGAGAACAACTG	0.582000													17	84					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671746	25671746	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr13:25671746C>T	ENST00000281589.3	+	1	1447	c.1410C>T	c.(1408-1410)gtC>gtT	p.V470V		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	470					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TTCCACGAGTCATGTCAACGC	0.542000													5	69					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49224308	49224308	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:49224308G>A	ENST00000308025.3	-	17	2486	c.2407C>T	c.(2407-2409)Cat>Tat	p.H803Y		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	803						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						CCTGGCTTATGCTGGGCATCT	0.562000													3	49					0	0	1	0	0
ITPKC	80271	broad.mit.edu	37	19	41245405	41245405	+	Silent	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:41245405C>T	ENST00000263370.2	+	7	2025	c.1992C>T	c.(1990-1992)gaC>gaT	p.D664D		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	664						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ACCGTGAGGACGGCTACCTCT	0.627000													3	14					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38172986	38172986	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:38172986G>A	ENST00000317025.8	-	11	2580	c.2063C>T	c.(2062-2064)tCa>tTa	p.S688L	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.S688L|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.S688L	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	688					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CGACAAACTTGAATCCATGGA	0.418000			T	NUP98	AML								32	73					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36053394	36053394	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr19:36053394G>A	ENST00000262623.3	-	4	391	c.363C>T	c.(361-363)atC>atT	p.I121I		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	121					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGATGAGGCAGATGGCGGCGG	0.657000													5	43					0	0	1	0	0
SLC37A3	84255	broad.mit.edu	37	7	140051218	140051218	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:140051218T>A	ENST00000326232.9	-	9	940	c.737A>T	c.(736-738)gAa>gTa	p.E246V	SLC37A3_ENST00000429996.2_3'UTR|SLC37A3_ENST00000447932.2_Missense_Mutation_p.E246V|SLC37A3_ENST00000340308.3_Missense_Mutation_p.E246V	NM_207113.1	NP_996996.1	Q8NCC5	SPX3_HUMAN	solute carrier family 37, member 3	246					carbohydrate transport|transmembrane transport	integral to membrane				endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|stomach(3)	24	Melanoma(164;0.0142)					TGAGTCTTCTTCAAAGTTTTC	0.433000													12	160					0	0	1	0	0
LRRC39	127495	broad.mit.edu	37	1	100618081	100618081	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:100618081C>G	ENST00000370138.1	-	9	1011		c.e9-1		LRRC39_ENST00000370137.1_Splice_Site|LRRC39_ENST00000342895.3_Splice_Site	NM_001256385.1	NP_001243314.1	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39											endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	13		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		GTTGACAAACCTAGAAGTTCA	0.368000													11	69					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248632	20248632	+	Missense_Mutation	SNP	C	C	A	rs142431986	byFrequency	TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:20248632C>A	ENST00000315957.4	+	1	232	c.151C>A	c.(151-153)Cta>Ata	p.L51I		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CACCATCAGGCTAGACCCTCA	0.418000													11	523					1.58986e-06	1.68056e-06	1	1	0
TRAJ42	28713	broad.mit.edu	37	14	22965925	22965925	+	RNA	SNP	T	T	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:22965925T>A	ENST00000390495.1	+	0	54																											CACTAAACTCTCTGTTAAACC	0.413000													4	56					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61854992	61854992	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr16:61854992T>G	ENST00000577390.1	-	6	1815	c.861A>C	c.(859-861)gaA>gaC	p.E287D	CDH8_ENST00000584337.1_Missense_Mutation_p.E287D|CDH8_ENST00000299345.6_Missense_Mutation_p.E287D|CDH8_ENST00000577730.1_Missense_Mutation_p.E287D	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	287	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GAACCACATCTTCCGGTACTG	0.398000													5	36					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27010432	27010432	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:27010432C>T	ENST00000382009.3	+	11	1849	c.1582C>T	c.(1582-1584)Cgc>Tgc	p.R528C	STIM2_ENST00000467011.1_Missense_Mutation_p.R433C|STIM2_ENST00000237364.5_Missense_Mutation_p.R520C|STIM2_ENST00000412829.2_Missense_Mutation_p.R520C|STIM2_ENST00000465503.1_Missense_Mutation_p.R441C|STIM2_ENST00000467087.1_Missense_Mutation_p.R433C	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	433					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				ACGACTTTTTCGCTGGCAACA	0.433000													10	61					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77043890	77043890	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr17:77043890T>C	ENST00000339142.2	+	5	1121	c.566T>C	c.(565-567)gTg>gCg	p.V189A	C1QTNF1_ENST00000392445.2_Missense_Mutation_p.V189A|C1QTNF1_ENST00000580454.1_Missense_Mutation_p.V189A|C1QTNF1_ENST00000311661.4_Missense_Mutation_p.V107A|C1QTNF1_ENST00000581774.1_Missense_Mutation_p.V189A|C1QTNF1_ENST00000582625.1_3'UTR|C1QTNF1_ENST00000579760.1_Missense_Mutation_p.V189A|C1QTNF1_ENST00000578229.1_Missense_Mutation_p.V107A|C1QTNF1_ENST00000580474.1_Missense_Mutation_p.V189A|C1QTNF1_ENST00000583904.1_Missense_Mutation_p.V189A|C1QTNF1_ENST00000354124.3_Missense_Mutation_p.V199A	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	189	C1q.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			TACTGCTACGTGCCCGGCCTC	0.527000													22	87					0	0	1	0	0
TMEM63A	9725	broad.mit.edu	37	1	226040394	226040394	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:226040394C>G	ENST00000366835.3	-	20	2144	c.1874G>C	c.(1873-1875)aGc>aCc	p.S625T		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	625						integral to membrane|lysosomal membrane	nucleotide binding	p.S625N(1)		breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					ACAAGTGATGCTGTAGGCCAC	0.572000													3	39					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112020459	112020459	+	Silent	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr9:112020459G>A	ENST00000374566.3	-	7	1267	c.750C>T	c.(748-750)tgC>tgT	p.C250C	EPB41L4B_ENST00000374557.4_Silent_p.C250C	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	250	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAAGGTACCTGCACTCTTTCC	0.398000													10	62					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32739136	32739136	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:32739136C>T	ENST00000265074.8	+	3	1402	c.1059C>T	c.(1057-1059)taC>taT	p.Y353Y	NPR3_ENST00000415685.2_Splice_Site_p.Y137Y|NPR3_ENST00000415167.2_Splice_Site_p.Y353Y|NPR3_ENST00000434067.2_Splice_Site_p.Y137Y	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	353					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	TGGAGGATTACGTAAGTGCCT	0.408000													11	34					0	0	1	0	0
C16orf58	64755	broad.mit.edu	37	16	31512031	31512031	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr16:31512031C>A	ENST00000327237.2	-	3	476	c.437G>T	c.(436-438)cGc>cTc	p.R146L	C16orf58_ENST00000430477.2_Missense_Mutation_p.R4L|C16orf58_ENST00000567994.1_Missense_Mutation_p.R101L|C16orf58_ENST00000570164.1_Missense_Mutation_p.R146L			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	146						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						AAAGACGATGCGGCCCAGCAT	0.542000													4	36					0.014758	0.0150934	1	1	0
CYP20A1	57404	broad.mit.edu	37	2	204131302	204131302	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:204131302G>T	ENST00000356079.4	+	5	621	c.498G>T	c.(496-498)caG>caT	p.Q166H	CYP20A1_ENST00000429815.2_Missense_Mutation_p.Q166H|CYP20A1_ENST00000461371.1_3'UTR	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	166						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						CCCTCAGCCAGCATATGCTTG	0.423000													5	135					0.014758	0.0150934	1	1	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775456	27775456	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:27775456C>T	ENST00000377401.2	-	1	253	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	77					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						CGGGAAGCCTCGCTTGCGATG	0.617000													41	109					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29976205	29976205	+	RNA	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr6:29976205C>T	ENST00000376797.3	-	0	1053				ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							ATGTGCAGCACAAGGGGCTGC	0.587000													3	32					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64894063	64894063	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:64894063C>T	ENST00000545908.1	+	12	1533	c.1304C>T	c.(1303-1305)cCa>cTa	p.P435L	MTHFD1_ENST00000216605.8_Missense_Mutation_p.P379L|CTD-2555O16.2_ENST00000556640.1_RNA			P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	379	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AGAATAACTCCAACACCCCTG	0.448000													9	43					0	0	1	0	0
KRT72	140807	broad.mit.edu	37	12	52981602	52981602	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:52981602C>T	ENST00000293745.2	-	7	1208	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	KRT72_ENST00000354310.4_Missense_Mutation_p.E333K|KRT72_ENST00000537672.2_Missense_Mutation_p.E375K|KRT72_ENST00000398066.3_Missense_Mutation_p.E187K	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	375	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		CCCCGCTGTTCAGCGTCGGCG	0.627000													4	32					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70170995	70170995	+	Silent	SNP	C	C	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr11:70170995C>A	ENST00000253925.7	+	4	624	c.409C>A	c.(409-411)Cgg>Agg	p.R137R	AP000487.6_ENST00000528607.1_RNA|CTA-797E19.2_ENST00000526017.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.R137R	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	137					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CAGGCATGAGCGGTCTCTTAG	0.443000													5	175					0.000602214	0.000626064	1	1	0
MET	4233	broad.mit.edu	37	7	116418859	116418859	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:116418859T>C	ENST00000397752.3	+	17	3570	c.3370T>C	c.(3370-3372)Ttt>Ctt	p.F1124L	MET_ENST00000318493.6_Missense_Mutation_p.F1142L|MET_ENST00000539704.1_5'UTR	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1124	Protein kinase.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AGTTTCCCAATTTCTGACCGA	0.443000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				8	43					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445809	49445809	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:49445809G>C	ENST00000301067.7	-	10	1656	c.1657C>G	c.(1657-1659)Cct>Gct	p.P553A		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGGGACAAAGGAGATTCTTCA	0.597000													10	69					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149864504	149864504	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:149864504G>C	ENST00000435030.1	+	23	2841	c.2473G>C	c.(2473-2475)Ggg>Cgg	p.G825R	KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Missense_Mutation_p.G730R|KIF5C_ENST00000397413.1_Missense_Mutation_p.G593R			O60282	KIF5C_HUMAN	kinesin family member 5C	825					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CGATGATGGAGGGGGCAGTGC	0.562000													3	28					0	0	1	0	0
ROPN1L	83853	broad.mit.edu	37	5	10442379	10442379	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr5:10442379C>T	ENST00000503804.1	+	2	621	c.100C>T	c.(100-102)Cag>Tag	p.Q34*	ROPN1L_ENST00000274134.4_Nonsense_Mutation_p.Q34*|ROPN1L_ENST00000510520.1_3'UTR			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	34	RIIa.				ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						CATCCGCACCCAGCCGGCCGA	0.667000													6	45					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31605324	31605324	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr12:31605324G>C	ENST00000389082.5	-	5	1443	c.1179C>G	c.(1177-1179)atC>atG	p.I393M	DENND5B_ENST00000536562.1_Missense_Mutation_p.I428M|DENND5B_ENST00000306833.6_Missense_Mutation_p.I428M|DENND5B_ENST00000354285.4_Missense_Mutation_p.I415M	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	393						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGAGTTCTTGGATAAAATCCA	0.403000													9	37					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13866940	13866940	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr20:13866940C>G	ENST00000284951.5	-	9	968	c.894G>C	c.(892-894)caG>caC	p.Q298H	SEL1L2_ENST00000378072.5_Missense_Mutation_p.Q298H|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	298						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TTACTTGTATCTGAACATCTC	0.368000													9	50					0	0	1	0	0
ZNF707	286075	broad.mit.edu	37	8	144776098	144776098	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr8:144776098G>A	ENST00000532205.1	+	8	1413	c.514G>A	c.(514-516)Gta>Ata	p.V172I	ZNF707_ENST00000532158.1_Missense_Mutation_p.V172I|ZNF707_ENST00000454097.1_Missense_Mutation_p.V172I|ZNF707_ENST00000418203.2_Missense_Mutation_p.V172I|ZNF707_ENST00000358656.4_Missense_Mutation_p.V172I			Q96C28	ZN707_HUMAN	zinc finger protein 707	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCAGCGCGCAGTAGAGCTGTC	0.672000													5	19					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37439059	37439059	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:37439059T>G	ENST00000234170.5	-	12	2872	c.2727A>C	c.(2725-2727)gaA>gaC	p.E909D	RP11-423P10.2_ENST00000606229.1_RNA|AC007390.5_ENST00000397064.2_Intron	NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	909					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				CAGCAAATTCTTCATCATCCA	0.363000													7	46					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107616137	107616137	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr7:107616137C>T	ENST00000393561.1	-	8	1442	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	LAMB1_ENST00000222399.6_Missense_Mutation_p.E396K|LAMB1_ENST00000393560.1_Missense_Mutation_p.E396K			P07942	LAMB1_HUMAN	laminin, beta 1	396	Laminin EGF-like 3.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACATACGTTCACAGAAATTA	0.473000													8	54					0	0	1	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547687	9547687	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr3:9547687C>G	ENST00000287585.6	-	3	892	c.607G>C	c.(607-609)Gac>Cac	p.D203H		NM_198560.2	NP_940962.1	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	203						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(3)|skin(1)	10	Medulloblastoma(99;0.227)					TGCAGCAGGTCTGTTTGCCGG	0.637000													4	58					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71512570	71512570	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr1:71512570C>T	ENST00000370924.4	-	1	921	c.691G>A	c.(691-693)Gcc>Acc	p.A231T	PTGER3_ENST00000354608.5_Missense_Mutation_p.A231T|PTGER3_ENST00000460330.1_Missense_Mutation_p.A231T|PTGER3_ENST00000306666.5_Missense_Mutation_p.A231T|PTGER3_ENST00000356595.4_Missense_Mutation_p.A231T|PTGER3_ENST00000414819.1_Missense_Mutation_p.A231T|PTGER3_ENST00000370932.2_Missense_Mutation_p.A231T|PTGER3_ENST00000370931.3_Missense_Mutation_p.A231T|PTGER3_ENST00000351052.5_Missense_Mutation_p.A231T	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	231					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	AAGGCAGAGGCGAAGAAAAGG	0.632000													11	71					0	0	1	0	0
GRXCR1	389207	broad.mit.edu	37	4	42965028	42965028	+	Silent	SNP	A	A	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr4:42965028A>G	ENST00000399770.2	+	2	504	c.504A>G	c.(502-504)gtA>gtG	p.V168V		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	168	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						ACCATCGCGTAAAATTTGAAG	0.428000													51	143					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20852874	20852874	+	Splice_Site	SNP	T	T	G			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr14:20852874T>G	ENST00000262715.5	-	22	3148		c.e22-2		TEP1_ENST00000556935.1_Splice_Site	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCACAGAGCTGACCACCAAA	0.512000													9	73					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37227804	37227805	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-ZF-AA58-01A-12D-A42E-08	TCGA-ZF-AA58-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76dfa963-9f1a-4802-a41f-716b306fecde	690c825d-7f81-470c-8cf6-a19e1ed87be3	g.chr2:37227804_37227805delCA	ENST00000233099.5	-	33	5564_5565	c.5469_5470delTG	c.(5467-5472)actgagfs	p.E1824fs	HEATR5B_ENST00000354531.2_Frame_Shift_Del_p.E1735fs	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1824							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				ACGCCAGCCTCAGTTTTGGCCA	0.431													19	97	---	---	---	---